AR022809A1 - DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
AR022809A1
AR022809A1 ARP000100922A ARP000100922A AR022809A1 AR 022809 A1 AR022809 A1 AR 022809A1 AR P000100922 A ARP000100922 A AR P000100922A AR P000100922 A ARP000100922 A AR P000100922A AR 022809 A1 AR022809 A1 AR 022809A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
ciclobuten
diona
therapeutics
Prior art date
Application number
ARP000100922A
Other languages
Spanish (es)
Original Assignee
Giraldo Osorio Oscar Hernan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giraldo Osorio Oscar Hernan filed Critical Giraldo Osorio Oscar Hernan
Publication of AR022809A1 publication Critical patent/AR022809A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

Los compuestos responden a la formula general (1) en la cual: R1 y R2 representan, independientemente entre sí, un átomo de hidrogeno, un grupo alquiloC1-6, alquenilo C2-6, -(CH2)n-cicloalquilo C3-6; R3 representa un átomo de hidrogeno, un grupo alquilo C1-6, -(CH2)n-cicloalquilo C3-6 o -CH2-CO2-alquilo C1-3o -CH2COOH; W representa un grupo NR4R5 para el cual R4 y R5 representan, independientemente entre sí, un átomo de hidrogeno, un grupo alquilo C1-6, alqueniloC2-6, alquinilo C2-6, -(CH2)n-cicloalquilo C3-6, alcoxi C1-4-alquilo C1-4, fluoroalquilo C1-6, perfluoroalquilo C1-2, -(CH2)m-piridilo o un grupo de formula(2) o R4 y R5 juntos forman una cadena alquileno C3-7 o representan un grupo de formula (3) o (4). Aplicacion en terapéutica.The compounds respond to the general formula (1) in which: R 1 and R 2 represent, independently of each other, a hydrogen atom, a C 1-6 alkyl group, C 2-6 alkenyl, - (CH 2) n C 3-6 cycloalkyl; R3 represents a hydrogen atom, a C1-6 alkyl group, - (CH2) n3-6 cycloalkyl or -CH2-CO2-C1-3o-CH2COOH alkyl; W represents an NR4R5 group for which R4 and R5 independently represent each other a hydrogen atom, a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, - (CH2) n3-6 cycloalkyl, alkoxy group C1-4-C1-4 alkyl, C1-6 fluoroalkyl, C1-2 perfluoroalkyl, - (CH2) m-pyridyl or a group of formula (2) or R4 and R5 together form a C3-7 alkylene chain or represent a group of formula (3) or (4). Therapeutic application.

ARP000100922A 1999-03-04 2000-03-02 DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AR022809A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902679A FR2790472B1 (en) 1999-03-04 1999-03-04 DERIVATIVES OF CYCLOBUTENE-3, 4-DIONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR022809A1 true AR022809A1 (en) 2002-09-04

Family

ID=9542807

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100922A AR022809A1 (en) 1999-03-04 2000-03-02 DERIVATIVES OF CICLOBUTEN-3,4-DIONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (6)

Country Link
AR (1) AR022809A1 (en)
AU (1) AU2922700A (en)
CO (1) CO5160254A1 (en)
FR (1) FR2790472B1 (en)
PE (1) PE20001494A1 (en)
WO (1) WO2000051973A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548508B2 (en) 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
US6495576B2 (en) 2001-02-07 2002-12-17 Abbott Laboratories Aminal diones as potassium channel openers
AR068509A1 (en) * 2007-09-19 2009-11-18 Jerini Ag BRADIQUININE B1 RECEIVER ANTAGOSNIST

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312210D0 (en) * 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds

Also Published As

Publication number Publication date
FR2790472B1 (en) 2001-04-06
AU2922700A (en) 2000-09-21
PE20001494A1 (en) 2001-03-04
CO5160254A1 (en) 2002-05-30
WO2000051973A1 (en) 2000-09-08
FR2790472A1 (en) 2000-09-08

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