AR022220A1 - DERIVATIVES OF THE IMIDAZO [4,5-C] -PIRIDIN-4-ONA, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, THE MEDICINAL BASE OF THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND ONE PROCEDURE TO PREPARE THESE FA COMPOSITIONS - Google Patents
DERIVATIVES OF THE IMIDAZO [4,5-C] -PIRIDIN-4-ONA, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, THE MEDICINAL BASE OF THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND ONE PROCEDURE TO PREPARE THESE FA COMPOSITIONSInfo
- Publication number
- AR022220A1 AR022220A1 ARP000100062A ARP000100062A AR022220A1 AR 022220 A1 AR022220 A1 AR 022220A1 AR P000100062 A ARP000100062 A AR P000100062A AR P000100062 A ARP000100062 A AR P000100062A AR 022220 A1 AR022220 A1 AR 022220A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compounds
- prepare
- procedure
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Los derivados de la imidazo[4,5-c]-piridin-4-ona, de formula (1), en donde: R representa H, alquilo C1-6 de cadena recta o ramificada o cicloalquilo C3-6;R1 representa Ar; R2 representa Ar; R3 representa H, R, R4, Hal, CN, COOH, COOA o CONH2; Ar yAr representan independientemente fenilo, naftilo o bifenilo nosustituido o mono, di o trisustituido con R, OH, Hal, CN, NO2, CF3, NH2, NHR, NR2, pirrolidin-1-ilo, piperidin-1-ilo, benciloxi, SO2NH2, SO2NHR, SO2NR2,-CONHR, -CONR2, -(CH2)n-NH2,-(CH2)n- NHR, -(CH2)n-NR2, -O-(CH2)n-NH2, -O-(CH2)n-NHR, -O-(CH2)n-NR2, R4 o sustituido en forma conjunta con -O-(CH2)m-O-, oisoquinoleinilo sustituido con NH2; R4 representa -C(=NH)-NH2, -NH-C(=NH)-NH2 o -C(=O)-N=C(NH2)2 no sustituido omonosustituido con -C OR, -COOR, -OH o con ungrupo protector de amino convencional, un compuesto de formula (2) o formula (3); A representa alquilo C1-4; Hal representa F, Cl, Br o I; m es 1 o 2; y n es 0o 1. Un procedimiento para preparar losderivados de la imidazo[4,5- c]-piridin-4-ona, de formula (1), en la cual: a) se los libera de uno de sus derivadosfuncionales por tratamiento con un agente de sovolisis o hidrogenolisis, o b) en un compuesto de formula (1) se transforma(n) uno ovarios restos R, R1, R2 y/oR3 en uno o varios restos R, R1, R2 y/o R3 diferentes, y/o c) se transforma una base o un ácido de formula (1) en una de sus sales. El empleo de los compuestosde formula (1) y/o de una de sus sales aceptables desde elpunto de vista patologico para prepar ar un medicamento destinado a la profilaxis y/o terapia de lasenfermedades tromboembolicas. Los compuestos de formula (1) son inhibidores del factor de coagulacion Xa.Derivatives of the imidazo [4,5-c] -pyridin-4-one, of formula (1), wherein: R represents H, straight or branched C1-6 alkyl or C3-6 cycloalkyl; R1 represents Ar ; R2 represents Ar; R3 represents H, R, R4, Hal, CN, COOH, COOA or CONH2; Ar and Ar independently represent phenyl, naphthyl or biphenyl substituted or mono, di or trisubstituted with R, OH, Hal, CN, NO2, CF3, NH2, NHR, NR2, pyrrolidin-1-yl, piperidin-1-yl, benzyloxy, SO2NH2 , SO2NHR, SO2NR2, -CONHR, -CONR2, - (CH2) n-NH2, - (CH2) n- NHR, - (CH2) n-NR2, -O- (CH2) n-NH2, -O- (CH2 ) n-NHR, -O- (CH2) n-NR2, R4 or jointly substituted with -O- (CH2) mO-, oisoquinoline substituted with NH2; R4 represents -C (= NH) -NH2, -NH-C (= NH) -NH2 or -C (= O) -N = C (NH2) 2 unsubstituted or substituted with -C OR, -COOR, -OH or with a conventional amino protecting group, a compound of formula (2) or formula (3); A represents C1-4 alkyl; Hal represents F, Cl, Br or I; m is 1 or 2; and n is 0o 1. A process for preparing the imidazo [4,5- c] -pyridin-4-one derivatives of formula (1), in which: a) they are released from one of their functional derivatives by treatment with a sovolysis or hydrogenolysis agent, or b) in a compound of formula (1) is transformed (n) one ovarian R, R1, R2 and / or R3 moieties into one or more different R, R1, R2 and / or R3 moieties, and / oc) a base or an acid of formula (1) is transformed into one of its salts. The use of the compounds of formula (1) and / or one of its acceptable salts from the pathological point of view to prepare a medicament for the prophylaxis and / or therapy of thromboembolic diseases. The compounds of formula (1) are inhibitors of coagulation factor Xa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19900471A DE19900471A1 (en) | 1999-01-08 | 1999-01-08 | Imidazo [4,5c] pyridin-4-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022220A1 true AR022220A1 (en) | 2002-09-04 |
Family
ID=7893790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000100062A AR022220A1 (en) | 1999-01-08 | 2000-01-07 | DERIVATIVES OF THE IMIDAZO [4,5-C] -PIRIDIN-4-ONA, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, THE MEDICINAL BASE OF THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND ONE PROCEDURE TO PREPARE THESE FA COMPOSITIONS |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1149099A2 (en) |
| JP (1) | JP2002534429A (en) |
| KR (1) | KR20010086085A (en) |
| CN (1) | CN1333772A (en) |
| AR (1) | AR022220A1 (en) |
| AU (1) | AU3041700A (en) |
| BR (1) | BR9916774A (en) |
| CA (1) | CA2357771A1 (en) |
| CZ (1) | CZ20012407A3 (en) |
| DE (1) | DE19900471A1 (en) |
| HU (1) | HUP0105054A3 (en) |
| NO (1) | NO20013384D0 (en) |
| PL (1) | PL349341A1 (en) |
| SK (1) | SK9442001A3 (en) |
| WO (1) | WO2000040583A2 (en) |
| ZA (1) | ZA200106454B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL142959A0 (en) | 1998-12-23 | 2002-04-21 | Du Pont Pharm Co | Nitrogen containing heterobicycles as factor xa inhibitors |
| NZ523184A (en) * | 2000-06-23 | 2004-06-25 | Bristol Myers Squibb Pharma Co | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors |
| AU2002310070A1 (en) | 2001-05-22 | 2002-12-03 | Bristol-Myers Squibb Company | Bicyclic inhibitors of factor xa |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| GB0225399D0 (en) * | 2002-10-31 | 2002-12-11 | Merck Sharp & Dohme | Therapeutic agents |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| US20050222198A1 (en) | 2003-12-22 | 2005-10-06 | K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
| CA2592388C (en) | 2004-12-21 | 2013-04-02 | Steven S. Bondy | Imidazo[4,5-c]pyridine compound and method of antiviral treatment |
| CA2614401A1 (en) | 2005-07-15 | 2007-01-25 | F. Hoffmann-La Roche Ag | Novel heteroaryl fused cyclic amines |
| EA015169B1 (en) | 2005-09-14 | 2011-06-30 | Такеда Фармасьютикал Компани Лимитед | Use of dipeptidyl peptidase inhibitors |
| EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| AU2007269614B2 (en) | 2006-07-07 | 2011-09-08 | Gilead Sciences, Inc. | Novel pyridazine compound and use thereof |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
| JP6689821B2 (en) * | 2014-08-12 | 2020-04-28 | シンジェンタ パーティシペーションズ アーゲー | Pesticidally Active Heterocyclic Derivatives Bearing Sulfur-Containing Substituents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW219935B (en) * | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
| JP2001524522A (en) * | 1997-12-01 | 2001-12-04 | メルク エンド カムパニー インコーポレーテッド | Thrombin inhibitor |
-
1999
- 1999-01-08 DE DE19900471A patent/DE19900471A1/en not_active Withdrawn
- 1999-12-21 JP JP2000592291A patent/JP2002534429A/en active Pending
- 1999-12-21 CA CA002357771A patent/CA2357771A1/en not_active Abandoned
- 1999-12-21 AU AU30417/00A patent/AU3041700A/en not_active Abandoned
- 1999-12-21 WO PCT/EP1999/010236 patent/WO2000040583A2/en not_active Application Discontinuation
- 1999-12-21 SK SK944-2001A patent/SK9442001A3/en unknown
- 1999-12-21 HU HU0105054A patent/HUP0105054A3/en unknown
- 1999-12-21 CN CN99815465A patent/CN1333772A/en active Pending
- 1999-12-21 CZ CZ20012407A patent/CZ20012407A3/en unknown
- 1999-12-21 BR BR9916774-3A patent/BR9916774A/en not_active Application Discontinuation
- 1999-12-21 EP EP99964639A patent/EP1149099A2/en not_active Withdrawn
- 1999-12-21 PL PL99349341A patent/PL349341A1/en unknown
- 1999-12-21 KR KR1020017007074A patent/KR20010086085A/en not_active Application Discontinuation
-
2000
- 2000-01-07 AR ARP000100062A patent/AR022220A1/en unknown
-
2001
- 2001-07-06 NO NO20013384A patent/NO20013384D0/en not_active Application Discontinuation
- 2001-08-06 ZA ZA200106454A patent/ZA200106454B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2357771A1 (en) | 2000-07-13 |
| NO20013384L (en) | 2001-07-06 |
| AU3041700A (en) | 2000-07-24 |
| KR20010086085A (en) | 2001-09-07 |
| WO2000040583A3 (en) | 2000-09-21 |
| CZ20012407A3 (en) | 2001-12-12 |
| ZA200106454B (en) | 2002-11-06 |
| EP1149099A2 (en) | 2001-10-31 |
| CN1333772A (en) | 2002-01-30 |
| SK9442001A3 (en) | 2002-05-09 |
| WO2000040583A2 (en) | 2000-07-13 |
| BR9916774A (en) | 2001-10-30 |
| DE19900471A1 (en) | 2000-07-13 |
| NO20013384D0 (en) | 2001-07-06 |
| HUP0105054A2 (en) | 2002-05-29 |
| PL349341A1 (en) | 2002-07-15 |
| HUP0105054A3 (en) | 2002-12-28 |
| JP2002534429A (en) | 2002-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR020688A1 (en) | DERIVATIVES OF THE IMIDAZO [4,5-C] -PIRIDIN-4-ONA, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, THE MEDICINAL BASE OF THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND ONE PROCEDURE TO PREPARE THESE COMPOSITIONS F | |
| AR022220A1 (en) | DERIVATIVES OF THE IMIDAZO [4,5-C] -PIRIDIN-4-ONA, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, THE MEDICINAL BASE OF THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND ONE PROCEDURE TO PREPARE THESE FA COMPOSITIONS | |
| ES2884067T3 (en) | Substituted indoline derivatives as inhibitors of dengue viral replication | |
| AR036099A1 (en) | DERIVATIVES 6- (ARIL-AMIDO OR ARIL-AMIDOMETIL) -NAFTALEN-2-ILOXI-ACIDOGENOS, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AS INHIBITORS OF THE TYPE-1 ACTIVATOR INHIBITOR OF PLASMINOGEN (1) | |
| AR024060A1 (en) | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | |
| AR036101A1 (en) | SUBSTITUTED NAFTIL INDOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AS INHIBITORS OF THE TYPE-1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | |
| AR054868A1 (en) | ISOQUINOLONE DERIVATIVES REPLACED WITH PIPERIDINYL | |
| AR102722A2 (en) | A PIRAZOLO-QUINAZOLINE DERIVATIVE, ITS USE, A PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, COMPOUNDS USED IN THEIR PREPARATION, A LIBRARY OF TWO OR MORE COMPOUNDS, AND A PRODUCT OR KIT | |
| AR046297A1 (en) | DPP INHIBITORS - IV METHODS TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AS ACTIVE AGENTS | |
| ES2683860T3 (en) | Novel succinate compounds with cell permeability | |
| AR088808A2 (en) | DERIVATIVES OF 2H-PIRIDAZIN-3-ONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND A PROCESS FOR THE PREPARATION OF SUCH DERIVATIVES AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION | |
| ECSP066383A (en) | DERIVATIVES OF 5-PHENYL-4-METHYL-TIAZOL-2-IL-AMINA AS INHIBITORS OF KINASA ENZYMES PHOSFATIDILINOSITOL 3 (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY ROUTES | |
| AR059425A1 (en) | CONDENSED CYCLE AMIDES OF BENCENSULPHONIC ACID, A METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF L-CPT | |
| DOP2001000270A (en) | 3-ADRENERGIC RECEIVER AGONISTS AND USES OF THE SAME | |
| EA200501098A1 (en) | ANTIBACTERIAL AGENTS | |
| AR041566A1 (en) | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES | |
| AR037329A1 (en) | PIRAZOLO PIRIMIDINONA COMPOUNDS, PROCEDURES FOR THE PREPARATION OF THE SAME, PHARMACEUTICAL COMPOSITIONS OF THE SAME AND USES OF THE SAME IN THE PREPARATION OF MEDICINES | |
| AR037517A1 (en) | DERIVATIVES OF NAFTIRIDINES, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF AN INFLAMMATORY DISEASE | |
| AR040925A1 (en) | USEFUL PIRAZOL COMPOUNDS AS PROTEINQUINASE INHIBITORS | |
| AR047076A1 (en) | PIRROLOTRIAZINE COMPOUNDS AS THYROSINE KINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS | |
| AR019777A1 (en) | DERIVATIVES OF DIACIL HYDRAZINE, A PROCEDURE FOR THEIR PREPARATION, THE USE OF THE SAME IN THE PREPARATION OF MEDICINES, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND A PROCEDURE TO PREPARE THESE PHARMACEUTICAL COMPOSITIONS | |
| AR050261A2 (en) | AMINO ACIDS AFFECTED BY THE ALFA-2-DELTA PROTEIN AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE TO PREPARE A MEDICINAL PRODUCT | |
| AR056014A1 (en) | COMPOUND 3-AMINOCARBAZOL, PHARMACEUTICAL COMPOSITION CONTAINING IT AND PROCEDURE FOR THE PREPARATION OF THE SAME | |
| AR062399A1 (en) | USE OF 2,5-DIHYDROXIBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTION DISEASES | |
| AR039651A1 (en) | ISOQUINOLINE DERIVATIVES |