AR021491A1 - Un compuesto de 6-azauracilo que inhibe a il-5, una composicion que lo comprende, un proceso para preparar dicha composicion, y el uso de dicho compuestopara la manufactura de un medicamento y de un agente de diagnostico - Google Patents

Un compuesto de 6-azauracilo que inhibe a il-5, una composicion que lo comprende, un proceso para preparar dicha composicion, y el uso de dicho compuestopara la manufactura de un medicamento y de un agente de diagnostico

Info

Publication number
AR021491A1
AR021491A1 ARP990104679A ARP990104679A AR021491A1 AR 021491 A1 AR021491 A1 AR 021491A1 AR P990104679 A ARP990104679 A AR P990104679A AR P990104679 A ARP990104679 A AR P990104679A AR 021491 A1 AR021491 A1 AR 021491A1
Authority
AR
Argentina
Prior art keywords
compound
composition
manufacture
diagnostic agent
azauracilo
Prior art date
Application number
ARP990104679A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR021491A1 publication Critical patent/AR021491A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se refiere a los compuestos derivados de 6-azauracilo que inhiben a Il-5 de la formula (1). Los N-oxidos, las sales de adicion farmacéuticamenteaceptables y sus formas estereoquímicamente isoméricas, donde R1, R2, R3, R4, X y p tienen su significadodado en la memoria descriptiva; a los procesospara su preparacion y las composiciones que los comprenden. Además, se refiere a su uso para la manufactura de una medicamento para tratar enfermedadesinflamatorias eosinofilas-dependiente y para la manufactura de un agente de diagnostico.
ARP990104679A 1998-09-18 1999-09-17 Un compuesto de 6-azauracilo que inhibe a il-5, una composicion que lo comprende, un proceso para preparar dicha composicion, y el uso de dicho compuestopara la manufactura de un medicamento y de un agente de diagnostico AR021491A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203148A EP0987265A1 (en) 1998-09-18 1998-09-18 Interleukin-5 inhibiting 6-azauracil derivatives

Publications (1)

Publication Number Publication Date
AR021491A1 true AR021491A1 (es) 2002-07-24

Family

ID=8234138

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990104679A AR021491A1 (es) 1998-09-18 1999-09-17 Un compuesto de 6-azauracilo que inhibe a il-5, una composicion que lo comprende, un proceso para preparar dicha composicion, y el uso de dicho compuestopara la manufactura de un medicamento y de un agente de diagnostico

Country Status (10)

Country Link
US (1) US6894046B2 (es)
EP (2) EP0987265A1 (es)
JP (1) JP2002526495A (es)
AR (1) AR021491A1 (es)
AT (1) ATE238301T1 (es)
AU (1) AU769133B2 (es)
CA (1) CA2344390A1 (es)
DE (1) DE69907233T2 (es)
ES (1) ES2198958T3 (es)
WO (1) WO2000017195A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
PL353475A1 (en) * 1999-08-06 2003-11-17 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
AU2003211385A1 (en) * 2002-02-28 2003-09-09 Takeda Chemical Industries, Ltd. Azole compounds
EA200602288A1 (ru) * 2004-05-29 2007-10-26 7ТиЭм ФАРМА А/С Замещённые тиазолуксусные кислоты в качестве лигандов crth2
BR112013003439A2 (pt) * 2010-08-16 2019-09-24 Boehringer Ingelheim Int "inibidores de oxadiazol de produção de leucotrieno"
EP2633855A1 (en) 2012-03-01 2013-09-04 Veterinärmedizinische Universität Wien Protease inhibitors for treating Trichomonas gallinae infections
JP2020100564A (ja) * 2017-04-03 2020-07-02 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1244024A (en) 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
US4631278A (en) 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
GB8602342D0 (en) 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
DE69615601T2 (de) * 1995-04-14 2002-07-11 Takeda Schering-Plough Animal Health K.K., Osaka Verfahren zur Herstellung von Triazinderivate
KR19980019182A (ko) * 1996-08-30 1998-06-05 다께다 구니오 1,2,4-트리아진-3,5-디온 유도체, 그의 생성법 및 그의 용도(1,2,4-triazine-3,5-dione derivatives, their production a nd use thereof)
NZ501627A (en) * 1997-07-10 2002-02-01 Janssen Pharmaceutica Nv 3,5-dioxo-2(3H)-triazine derivatives substituted by 4-(phenylmethyl)phenyl useful as IL-5 inhibitors
PL337947A1 (en) * 1997-07-10 2000-09-11 Janssen Pharmaceutica Nv Il-5 inhibiting derivatives of 6-azauracil
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives

Also Published As

Publication number Publication date
EP1114046A1 (en) 2001-07-11
US20020010177A1 (en) 2002-01-24
CA2344390A1 (en) 2000-03-30
US6894046B2 (en) 2005-05-17
JP2002526495A (ja) 2002-08-20
ATE238301T1 (de) 2003-05-15
EP1114046B1 (en) 2003-04-23
EP0987265A1 (en) 2000-03-22
DE69907233D1 (de) 2003-05-28
DE69907233T2 (de) 2004-04-01
ES2198958T3 (es) 2004-02-01
WO2000017195A1 (en) 2000-03-30
AU769133B2 (en) 2004-01-15
AU6082599A (en) 2000-04-10

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