AR017686A1 - Una proteina mutante hedgehog activa, un proceso para su preparacion y su uso para propositos farmaceuticos - Google Patents
Una proteina mutante hedgehog activa, un proceso para su preparacion y su uso para propositos farmaceuticosInfo
- Publication number
- AR017686A1 AR017686A1 ARP980106010A ARP980106010A AR017686A1 AR 017686 A1 AR017686 A1 AR 017686A1 AR P980106010 A ARP980106010 A AR P980106010A AR P980106010 A ARP980106010 A AR P980106010A AR 017686 A1 AR017686 A1 AR 017686A1
- Authority
- AR
- Argentina
- Prior art keywords
- activity
- preparation
- mutant protein
- pharmaceutical purposes
- active mutant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un mutante de la proteína hedgehog procesada post-translacionalmente, la cual, tiene un peso molecular de 22 +- 2 kDa en condiciones de alquilacion;tiene un peso molecular de 24 +- 2 kDa en condiciones de reduccion; se estabiliza con respecto a su actividad, mediante la suramina; se inactiva cuando 8 o másaminoácidos se escinden por el extremo N; se inactiva en un 90% o más cuando se incuba con 10 mmoles/litro de DTE durante 2,5 horas a 37*C; induce unaactividad para la fosfatasa alcalina de aprox. 90 nmoles de pNP/min/mg a una concentracion de 5nmoles/litro en presencia de suramina; no se modifica medianteel colesterol; y tiene una actividad que es por lo menos 50 veces la de la proteína hh recombinante aislada del citoplasma de E. coli, posee una actividadaumentada varias veces.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97120891A EP0919618A1 (de) | 1997-11-28 | 1997-11-28 | Aktive Hedgehog-Protein-Mutante, Verfahren zur Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017686A1 true AR017686A1 (es) | 2001-09-12 |
Family
ID=8227694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106010A AR017686A1 (es) | 1997-11-28 | 1998-11-26 | Una proteina mutante hedgehog activa, un proceso para su preparacion y su uso para propositos farmaceuticos |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0919618A1 (es) |
| AR (1) | AR017686A1 (es) |
| CO (1) | CO4850631A1 (es) |
| PE (1) | PE20000004A1 (es) |
| ZA (1) | ZA9810846B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
-
1997
- 1997-11-28 EP EP97120891A patent/EP0919618A1/de not_active Withdrawn
-
1998
- 1998-11-26 ZA ZA9810846A patent/ZA9810846B/xx unknown
- 1998-11-26 CO CO98069942A patent/CO4850631A1/es unknown
- 1998-11-26 AR ARP980106010A patent/AR017686A1/es unknown
- 1998-11-26 PE PE1998001155A patent/PE20000004A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO4850631A1 (es) | 1999-10-26 |
| ZA9810846B (en) | 1999-06-01 |
| PE20000004A1 (es) | 2000-01-29 |
| EP0919618A1 (de) | 1999-06-02 |
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