AR013206A1 - DERIVATIVES INDOL AND 2,3-DIHIDROINDOL, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF SENSITIVE DISORDERS TO THE INHIBITION OF SEROTONIN REABSORPTION AND ANTAGON 5. - Google Patents
DERIVATIVES INDOL AND 2,3-DIHIDROINDOL, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF SENSITIVE DISORDERS TO THE INHIBITION OF SEROTONIN REABSORPTION AND ANTAGON 5.Info
- Publication number
- AR013206A1 AR013206A1 ARP980103400A AR013206A1 AR 013206 A1 AR013206 A1 AR 013206A1 AR P980103400 A ARP980103400 A AR P980103400A AR 013206 A1 AR013206 A1 AR 013206A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- treatment
- aryl
- inhibition
- alkyl
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Indol y derivados de 2,3-dihidroindol que tienen la formula (I) cualquiera de su enantiomeros o cualquier mezcla de los mismos, o una sal de ácido de losmismos, donde X es -O-, -S-, O-CR4R5- y Y es -CR6-R7-, CR8R7-CR8R9-, O -CR6=CR7-, o Xe Y conjuntamente forman un grupo -CR4=CR5-CR6R7-; Z es -O-, o-S-; W es N, C o CH; A es un grupo seleccionado de un grupo de formula (II), (III) y (IV) donde las líneas de puntos se refieren a un enlace opcional; R1,R2, R3, R13, R14, R15, R16 Yr17 están independientemente seleccionados de hidrogeno, halogeno, trifluormetilo, alquilo, alquenilo, alquinilo,cicloalquilo, alcoxi, hidroxi, formilo, acilo, amino, alquilamino, dialquilamino, acilamino, alcoxicarbonilamino,aminocar bonlamino,alquilaminocarbonilamino, dialquilaminocarbonilamino, nitro, ciano y arilo o arilalquilo, donde arilo puede ser sustituido con halogeno, trifluormetilo,alcoxi, hidroxi, amino, alquilamino, nitro y ciano; R4, R5, R6, R7 R8 y R9están cada uno independientemente seleccionados de hidrogeno y alquilo; y R11está seleccionado de hidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, arilo, arilalquilo, acilo y formilo; composiciones farmacéuticas que contienenlos compuestosanter iormene mencionados y el uso de dichos compuestos para la preparacion de un medicamento para el tratamiento de desordenes sensibles a lainhibicion de la reabsorcion de seotonina y antagonismo de receptores 5-HT1A (por ejemplo, desordenesafectiv os, incluyendo depresion, sicosis, desordenesde pánico y desorden compulsivo obsesivo). Estos compuestos son considerados particularmente utiles como principio rápido de la accion de medicamentos parael tratamietno de desordenes afectivoscomo dep resion.Indole and 2,3-dihydroindole derivatives having formula (I) any of its enantiomers or any mixture thereof, or an acid salt thereof, where X is -O-, -S-, O-CR4R5- and Y is -CR6-R7-, CR8R7-CR8R9-, O -CR6 = CR7-, or Xe Y together form a group -CR4 = CR5-CR6R7-; Z is -O-, o-S-; W is N, C or CH; A is a group selected from a group of formula (II), (III) and (IV) where the dotted lines refer to an optional bond; R1, R2, R3, R13, R14, R15, R16 Yr17 are independently selected from hydrogen, halogen, trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, hydroxy, formyl, acyl, amino, alkylamino, dialkylamino, acylamino, alkoxycarbonylamino, aminocar bonlamino, alkylaminocarbonylamino, dialkylaminocarbonylamino, nitro, cyano and aryl or arylalkyl, where aryl can be substituted with halogen, trifluoromethyl, alkoxy, hydroxy, amino, alkylamino, nitro and cyano; R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and alkyl; and R11 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, acyl, and formyl; Pharmaceutical compositions containing the above mentioned compounds and the use of said compounds for the preparation of a medicament for the treatment of disorders sensitive to the inhibition of seotonin reuptake and antagonism of 5-HT1A receptors (for example, affective disorders, including depression, psychosis , panic disorder and obsessive compulsive disorder). These compounds are considered particularly useful as a quick start of action for medications for the treatment of affective disorders such as depression.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK89297 | 1997-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR013206A1 true AR013206A1 (en) | 2000-12-13 |
Family
ID=8098721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980103400 AR013206A1 (en) | 1997-07-25 | 1998-07-13 | DERIVATIVES INDOL AND 2,3-DIHIDROINDOL, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF SENSITIVE DISORDERS TO THE INHIBITION OF SEROTONIN REABSORPTION AND ANTAGON 5. |
Country Status (13)
Country | Link |
---|---|
CN (3) | CN1286833C (en) |
AR (1) | AR013206A1 (en) |
BR (1) | BR9810790A (en) |
EA (1) | EA001890B1 (en) |
HK (3) | HK1030220A1 (en) |
IL (1) | IL133990A (en) |
IS (1) | IS2024B (en) |
NO (1) | NO318610B1 (en) |
PL (1) | PL190924B1 (en) |
SK (1) | SK284866B6 (en) |
TR (1) | TR200000231T2 (en) |
UA (1) | UA59408C2 (en) |
ZA (1) | ZA986237B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103420989B (en) * | 2012-05-15 | 2016-03-23 | 华中科技大学 | Benzodioxane derivative and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
DE4127849A1 (en) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | BENZODIOXAN DERIVATIVES |
FR2692264B1 (en) * | 1992-06-12 | 1994-08-05 | Adir | NOVEL 1,4-DISUBSTITUTED PIPERAZINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1998
- 1998-07-13 AR ARP980103400 patent/AR013206A1/en active IP Right Grant
- 1998-07-14 ZA ZA986237A patent/ZA986237B/en unknown
- 1998-07-20 BR BR9810790-9A patent/BR9810790A/en not_active Application Discontinuation
- 1998-07-20 SK SK95-2000A patent/SK284866B6/en not_active IP Right Cessation
- 1998-07-20 UA UA2000020949A patent/UA59408C2/en unknown
- 1998-07-20 CN CN 03106002 patent/CN1286833C/en not_active Expired - Fee Related
- 1998-07-20 CN CN 98807554 patent/CN1127501C/en not_active Expired - Fee Related
- 1998-07-20 PL PL338194A patent/PL190924B1/en not_active IP Right Cessation
- 1998-07-20 IL IL13399098A patent/IL133990A/en not_active IP Right Cessation
- 1998-07-20 CN CNB03106003XA patent/CN1293075C/en not_active Expired - Fee Related
- 1998-07-20 TR TR2000/00231T patent/TR200000231T2/en unknown
- 1998-07-20 EA EA200000162A patent/EA001890B1/en not_active IP Right Cessation
-
2000
- 2000-01-11 IS IS5334A patent/IS2024B/en unknown
- 2000-01-25 NO NO20000372A patent/NO318610B1/en not_active IP Right Cessation
-
2001
- 2001-02-21 HK HK01101274A patent/HK1030220A1/en not_active IP Right Cessation
-
2004
- 2004-12-13 HK HK04109852A patent/HK1066806A1/en not_active IP Right Cessation
- 2004-12-13 HK HK04109853A patent/HK1066807A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL338194A1 (en) | 2000-10-09 |
IL133990A (en) | 2003-09-17 |
EA001890B1 (en) | 2001-10-22 |
BR9810790A (en) | 2000-07-25 |
SK952000A3 (en) | 2001-03-12 |
IS2024B (en) | 2005-08-15 |
PL190924B1 (en) | 2006-02-28 |
CN1515568A (en) | 2004-07-28 |
IS5334A (en) | 2000-01-11 |
NO20000372L (en) | 2000-03-21 |
CN1293075C (en) | 2007-01-03 |
HK1066806A1 (en) | 2005-04-01 |
SK284866B6 (en) | 2006-01-05 |
NO20000372D0 (en) | 2000-01-25 |
ZA986237B (en) | 1999-03-31 |
HK1066807A1 (en) | 2005-04-01 |
HK1030220A1 (en) | 2001-04-27 |
CN1286833C (en) | 2006-11-29 |
NO318610B1 (en) | 2005-04-18 |
TR200000231T2 (en) | 2000-07-21 |
CN1265107A (en) | 2000-08-30 |
IL133990A0 (en) | 2001-04-30 |
EA200000162A1 (en) | 2000-10-30 |
CN1127501C (en) | 2003-11-12 |
UA59408C2 (en) | 2003-09-15 |
CN1515569A (en) | 2004-07-28 |
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