AR009807A1 - Peptidos que contienen analogos de cisteina. - Google Patents

Peptidos que contienen analogos de cisteina.

Info

Publication number
AR009807A1
AR009807A1 ARP970104371A ARP970104371A AR009807A1 AR 009807 A1 AR009807 A1 AR 009807A1 AR P970104371 A ARP970104371 A AR P970104371A AR P970104371 A ARP970104371 A AR P970104371A AR 009807 A1 AR009807 A1 AR 009807A1
Authority
AR
Argentina
Prior art keywords
amino acid
side chains
cysteine
formula
residue
Prior art date
Application number
ARP970104371A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR009807A1 publication Critical patent/AR009807A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un péptido fisiologicamente activo de formula (I): A-R1-R2-R3-(R4)x-B, en la cual cada A se selecciona independientemente entre H, un grupo protector,o por lo menos un residuo aminoácido seleccionado independientemente entre el grupo de residuos aminoácidos que tienen cadenas laterales alifáticas, cadenaslaterales oxhidrilo alifáticas, cadenas laterales básicas, cadenas laterales acídicas, grupos amino secundario, cadenas laterales amida, cadenas lateralesaromáticas y cadenas lateralescon contenido de azufre; R1 es un residuo de un aminoácido seleccionado entre glicina (Gly), prolina (Pro), ácido aspártico(Asp), arginina (Arg), alanina (Ala), isoleucina (Ile), triptofano (Trp), serina (Ser), cisteína (Cys), ácido glutámico(Glu), aspargina (Asn) y R8; R2es un residuo de un aminoácido seleccionado entre cisteína (Cys), prolina (Pro), isoleucina (Ile), alanina (Ala), tirosina (Tyr), treonina (Thr),arginina (Arg), ácido pipecolico (Pec), y R8; R3 es un residuo de un aminoácido seleccionado entre cisteína (Cys) y R8 y por lo menos uno de R1, R2 y R3 esR8 y como mucho uno de R1, R2 y R3 es cisteína; y R8 es un residuo aminoácido de formula (II) o formula (III), en donde cada uno de R5 y R6 esindependientementeseleccionado entre H, alquilo, arilo y alcoxi; R7 es SOH, SO2H, SO3H, SR9, SeR9 o TeR9 (en donde R9 es H, alquilo, arilo, alcoxi, SR10,SOR10 o SO2R10 y R10 es H, alquilo, arilo o alcoxi); n se selecciona entre 0, 1, 2, 3 y 4; y m se seleccionaentre 0, 1, 2, 3 y 4; siempre que, cuando R8 seaun residuo de aminoácidos de formula (II), cuando n sea 0 y R7 sea SH, R5 y R6 no sean ambos H; R4 es un residuo de un aminoácido seleccionado entre glicina(Gly), fenilalanina (Phe), valina (Val), isoleucina (Ile), lisina (Lys), prolina (Pro), triptofano (Trp), tirosina (Tys), ácido glutámico (Glu), leucina
ARP970104371A 1996-09-23 1997-09-23 Peptidos que contienen analogos de cisteina. AR009807A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603468A SE9603468D0 (sv) 1996-09-23 1996-09-23 New compounds

Publications (1)

Publication Number Publication Date
AR009807A1 true AR009807A1 (es) 2000-05-03

Family

ID=20403990

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104371A AR009807A1 (es) 1996-09-23 1997-09-23 Peptidos que contienen analogos de cisteina.

Country Status (5)

Country Link
AR (1) AR009807A1 (es)
AU (1) AU4406397A (es)
SE (1) SE9603468D0 (es)
WO (1) WO1998012219A1 (es)
ZA (1) ZA978472B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1213062C (zh) 2001-07-13 2005-08-03 一泰医药研究（深圳）有限公司 序列号13的生物活性肽
EP1947109A3 (en) * 2001-07-13 2008-10-01 CMS Peptides Patent Holding Company Limited Biologically active peptides
EP1909815A4 (en) 2005-07-26 2011-05-18 Cms Peptides Patent Holding Company Ltd NEW BIOLOGICALLY ACTIVE PEPTIDES AND THEIR NEW USES
WO2007144411A1 (en) * 2006-06-14 2007-12-21 Centre National De La Recherche Scientifique (Cnrs) New supported oxidation reactants, process for their preparation and uses thereof
DK3160513T3 (da) 2014-06-30 2020-04-06 Glykos Finland Oy Saccharidderivat af en toksisk payload og antistofkonjugater deraf
US9988434B2 (en) * 2014-09-12 2018-06-05 Wisconsin Alumni Research Foundation Optimal interstrand bridge for collagen mimics
AU2017273857B2 (en) 2016-06-01 2021-08-19 Athira Pharma, Inc. Compounds
CN108484640B (zh) * 2018-05-22 2020-09-15 南京华威医药科技集团有限公司 一种抗肿瘤的细胞凋亡蛋白抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0271041A3 (en) * 1986-12-10 1990-04-11 Abbott Laboratories Atrial peptide derivatives
WO1988005783A1 (en) * 1987-01-28 1988-08-11 Ortho Pharmaceutical Corporation Immunosuppressive peptides and methods of use
DE3841759A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
WO1990009162A2 (en) * 1989-01-31 1990-08-23 Abbott Laboratories Anaphylatoxin-receptor ligands
US5494672A (en) * 1989-04-28 1996-02-27 S.P.I. Synthetic Peptides Incorporated Pseudomonas peptide composition and method
US5137873A (en) * 1990-07-27 1992-08-11 The Children's Medical Center Corporation Substance p and tachykinin agonists for treatment of alzheimer's disease
WO1993024136A1 (en) * 1991-01-17 1993-12-09 Terman David S Tumor killing effects of enterotoxins, superantigens, and related compounds
JP3188457B2 (ja) * 1992-03-07 2001-07-16 森永乳業株式会社 免疫促進剤
US6696061B1 (en) * 1992-08-11 2004-02-24 President And Fellows Of Harvard College Immunomodulatory peptides
JPH08503694A (ja) * 1992-09-08 1996-04-23 セントコー・インコーポレーテッド ペプチド系の細胞接着阻害物質
AUPM446594A0 (en) * 1994-03-16 1994-04-14 Csl Limited Cytotoxic t-cell epitopes identified within epstein-barr virus
CA2187336A1 (en) * 1994-04-08 1995-10-19 Henry M. Franzen Pharmaceutical formulations for treating japanese cedar pollen allergy
PT769054E (pt) * 1994-07-05 2000-11-30 Steeno Res Group A S Imunoreguladores
SE9403526D0 (sv) * 1994-10-14 1994-10-14 Astra Ab New Peptides
EP0923604A1 (en) * 1996-04-12 1999-06-23 Astra Aktiebolag Cysteine-containing or methioine-containing peptides with immunomodulatory effects

Also Published As

Publication number Publication date
AU4406397A (en) 1998-04-14
SE9603468D0 (sv) 1996-09-23
ZA978472B (en) 1998-03-23
WO1998012219A1 (en) 1998-03-26

Similar Documents

Publication Publication Date Title
DK222989D0 (da) Antiaggregatoriske peptider, farmaceutiske midler indeholdende peptiderne samt fremgangsmaader til anvendelse heraf
SI20643B (sl) IL-2-selektivni agonisti in antagonisti
ES2273447T3 (es) Plantas transgenicas resistentes a insectos y procedimientos para mejorar la actividad frente a insectos.
AR009807A1 (es) Peptidos que contienen analogos de cisteina.
NZ333606A (en) Isolated peptides derived from MAGE-2
ATE245999T1 (de) Aminosäurezusammensetzungen
ES2054365T3 (es) Inhibicion de la via de la regla del n final en celulas vivas.
EP2386566A3 (en) Chi-conotoxin peptides (II)
KR870007203A (ko) 펩타이드를 제조하는 방법
DK0896615T3 (da) Peptid fra opløselig form af acetylcholinesterase, der er aktivt som calcium-kanal-modulator
ES2178207T3 (es) Nuevos derivados de triptolida utiles en el tratamiento de enfermedades autoinmunes.
JPS5594934A (en) Peptide type polymer and pharmaceutic composition containing it
IL105822A0 (en) Treatment of tropical spastic paresis with peptide-t
KR890701571A (ko) 4h-3, 1-벤즈옥사진-4-온 화합물 및 세린 프로테아제 억제를 위한 그의 약학 조성물
SE9603465D0 (sv) New compounds
ATE42308T1 (de) Pharmakologisch aktive peptide.
AR009805A1 (es) Peptidos que contienen cisteina
ATE30919T1 (de) Magensekretion hemmende peptidderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
ATE124955T1 (de) Substrat-peptide.
DE3782880D1 (de) Hemmende peptide.
TR199901831T2 (xx) Kollagen-II'ye �zg� bir T-h�cresi epitopundan olu�an peptitler.
NO963851D0 (no) Biotinderivater
RU94024392A (ru) Минерально-аминокислотный концентрат
SE9603467D0 (sv) New compounds
US3639383A (en) Complexes of a.c.t.h. peptides and polyphosphoric acids