AR009556A1 - INDAZOL TRICYCLIC DERIVED COMPOUNDS, PREPARATION PROCEDURE; DRUGS AND PHARMACEUTICAL COMPOSITION THAT CONTAIN IT - Google Patents
INDAZOL TRICYCLIC DERIVED COMPOUNDS, PREPARATION PROCEDURE; DRUGS AND PHARMACEUTICAL COMPOSITION THAT CONTAIN ITInfo
- Publication number
- AR009556A1 AR009556A1 ARP970104083A ARP970104083A AR009556A1 AR 009556 A1 AR009556 A1 AR 009556A1 AR P970104083 A ARP970104083 A AR P970104083A AR P970104083 A ARP970104083 A AR P970104083A AR 009556 A1 AR009556 A1 AR 009556A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- pharmaceutical composition
- tricyclic
- indazol
- drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a compuestos de derivados de indazol tricíclico de formula general (I), en donde: X es un átomo de oxígeno o un grupo metileno, R1 esun átomo de hidrogeno tal como bromo, cloro o fluor, un grupo C1-C4 alcoxilo, o un grupo hiroxiloo amino; R2, R3 y R4, idénticos o diferentes son o bien unátomo de hidrogeno, o bien un grupo C1-C4 alquilo, lineal o ramificado, un grupo fenilo o un grupo bencilo, y R5 es un átomo de hidrogeno, un grupohidroxilo, un grupo amino o un grupo C1-C4, en forma de enantiomero, de diastereoisomero, inclusive de mezcla racémica así como su sal de adicion deácidos farmacéuticamente aceptables. Además, se refiere a un procedimiento de preparacion de dichos compuestos y a un medicamento yuna composicionfarmacéutica que lo contienen.It refers to compounds of tricyclic indazole derivatives of general formula (I), where: X is an oxygen atom or a methylene group, R1 is a hydrogen atom such as bromine, chlorine or fluorine, a C1-C4 alkoxy group, or a hiroxyloo amino group; R2, R3 and R4, identical or different, are either a hydrogen atom, or a C1-C4 alkyl group, linear or branched, a phenyl group or a benzyl group, and R5 is a hydrogen atom, a hydroxyl group, a group amino or a C1-C4 group, in the form of an enantiomer, of a diastereoisomer, including a racemic mixture, as well as its pharmaceutically acceptable acid addition salt. Furthermore, it refers to a process for the preparation of said compounds and to a drug and a pharmaceutical composition containing it.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9611116A FR2753196B1 (en) | 1996-09-12 | 1996-09-12 | TRICYCLIC INDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
Publication Number | Publication Date |
---|---|
AR009556A1 true AR009556A1 (en) | 2000-04-26 |
Family
ID=9495672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970104083A AR009556A1 (en) | 1996-09-12 | 1997-09-08 | INDAZOL TRICYCLIC DERIVED COMPOUNDS, PREPARATION PROCEDURE; DRUGS AND PHARMACEUTICAL COMPOSITION THAT CONTAIN IT |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR009556A1 (en) |
AU (1) | AU4211997A (en) |
FR (1) | FR2753196B1 (en) |
WO (1) | WO1998011112A1 (en) |
ZA (1) | ZA978196B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156780A (en) * | 1996-10-17 | 2000-12-05 | Milkhaus Laboratory, Inc. | Treatment of fecal incontinence |
FR2769915B1 (en) * | 1997-10-21 | 2000-10-13 | Synthelabo | TRICYCLIC INDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
DK1104289T3 (en) * | 1998-08-21 | 2006-05-15 | Novartis Ag | New oral formulations for 5-HT 4 agonists or antagonists |
WO2007120599A2 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands |
WO2015006193A1 (en) * | 2013-07-08 | 2015-01-15 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950759A (en) * | 1988-07-07 | 1990-08-21 | Duphar International Research B.V. | Substituted 1,7-annelated 1H-indazoles |
FR2710915B1 (en) * | 1993-10-04 | 1995-11-24 | Synthelabo | Piperidine derivatives, their preparation and their therapeutic use. |
-
1996
- 1996-09-12 FR FR9611116A patent/FR2753196B1/en not_active Expired - Fee Related
-
1997
- 1997-09-08 AR ARP970104083A patent/AR009556A1/en unknown
- 1997-09-09 WO PCT/FR1997/001581 patent/WO1998011112A1/en active Application Filing
- 1997-09-09 AU AU42119/97A patent/AU4211997A/en not_active Abandoned
- 1997-09-11 ZA ZA9708196A patent/ZA978196B/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR2753196B1 (en) | 1998-10-23 |
ZA978196B (en) | 1998-03-03 |
AU4211997A (en) | 1998-04-02 |
WO1998011112A1 (en) | 1998-03-19 |
FR2753196A1 (en) | 1998-03-13 |
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