CO4990933A1 - INDAZOL TRICYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS - Google Patents

INDAZOL TRICYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

Info

Publication number
CO4990933A1
CO4990933A1 CO98060914A CO98060914A CO4990933A1 CO 4990933 A1 CO4990933 A1 CO 4990933A1 CO 98060914 A CO98060914 A CO 98060914A CO 98060914 A CO98060914 A CO 98060914A CO 4990933 A1 CO4990933 A1 CO 4990933A1
Authority
CO
Colombia
Prior art keywords
group
indazol
therapeutics
preparation
application
Prior art date
Application number
CO98060914A
Other languages
Spanish (es)
Inventor
Even Luc
Claudie Gautier
Michel Aletru
Philippe Bovy
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of CO4990933A1 publication Critical patent/CO4990933A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuesto de fórmula (I)en la cual: R1 representa un átomo de hidrógeno, un halógeno, un grupo C1-4 alcoxilo, metilo, hidroxi o amino, R2 y R3 , idénticos o diferentes, representan un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un fenilo o un bencilo, X representa un átomo de oxígeno, un grupo -NH- o -N(C1-4 alquilo)-, y A es un grupo de fórmula B o C en las cuales:Y representa un átomo de nitrógeno o un grupo metileno, R4 representa un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un bencilo, n es igual a O o 1, y m es igual a O o 1, en forma de enantiómero, de diastereoisómero, incluida la mezcla racémica así como sus sales de adición con ácidos farmacéuticamente aceptables.Compound of formula (I) in which: R1 represents a hydrogen atom, a halogen, a C1-4 alkoxy, methyl, hydroxy or amino group, R2 and R3, identical or different, represent a hydrogen atom, an alkyl group from 1 to 4 carbon atoms, a phenyl or a benzyl, X represents an oxygen atom, a group -NH- or -N (C1-4 alkyl) -, and A is a group of formula B or C in which : Y represents a nitrogen atom or a methylene group, R4 represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms, a benzyl, n is equal to O or 1, and m is equal to O or 1, in enantiomer form, of diastereoisomer, including racemic mixture as well as its addition salts with pharmaceutically acceptable acids.

CO98060914A 1997-10-21 1998-10-20 INDAZOL TRICYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS CO4990933A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9713149A FR2769915B1 (en) 1997-10-21 1997-10-21 TRICYCLIC INDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
CO4990933A1 true CO4990933A1 (en) 2000-12-26

Family

ID=9512452

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98060914A CO4990933A1 (en) 1997-10-21 1998-10-20 INDAZOL TRICYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

Country Status (9)

Country Link
EP (1) EP1025109A1 (en)
JP (1) JP2001520231A (en)
AR (1) AR017366A1 (en)
AU (1) AU9633098A (en)
CO (1) CO4990933A1 (en)
FR (1) FR2769915B1 (en)
TW (1) TW407160B (en)
WO (1) WO1999020633A1 (en)
ZA (1) ZA989556B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6558708B1 (en) 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
FR2792318B1 (en) * 1999-04-16 2001-06-15 Synthelabo INDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AR036040A1 (en) 2001-06-12 2004-08-04 Upjohn Co MULTICICLIC HETEROARYL COMPOUNDS REPLACED WITH QUINUCLIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PL369895A1 (en) 2001-10-02 2005-05-02 Pharmacia & Upjohn Company Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
EP1442037A1 (en) 2001-11-09 2004-08-04 PHARMACIA & UPJOHN COMPANY Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
WO2003070731A2 (en) 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
JP2005523288A (en) 2002-02-19 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Fused bicyclic-N-bridged-heteroaromatic carboxamides for disease treatment
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
EP1807423B1 (en) 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
ES2332808T3 (en) 2004-11-05 2010-02-12 Theravance, Inc. AGONIST COMPOUNDS OF THE RECEIVER 5-HT4.
WO2006069097A2 (en) * 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
NZ555180A (en) 2004-12-22 2010-09-30 Theravance Inc Indazole-carboxamide compounds useful as 5-HT4 receptor agonists
EP1871772B1 (en) 2005-03-02 2014-09-10 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
JP4375749B2 (en) 2005-11-22 2009-12-02 本田技研工業株式会社 Resin garnish structure for vehicles
WO2007120599A2 (en) 2006-04-12 2007-10-25 Wyeth Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350130A3 (en) * 1988-07-07 1991-07-10 Duphar International Research B.V New substituted 1,7-annelated 1h-indazoles
FR2753196B1 (en) * 1996-09-12 1998-10-23 Synthelabo TRICYCLIC INDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
EP1025109A1 (en) 2000-08-09
WO1999020633A1 (en) 1999-04-29
JP2001520231A (en) 2001-10-30
ZA989556B (en) 1999-04-20
FR2769915A1 (en) 1999-04-23
FR2769915B1 (en) 2000-10-13
TW407160B (en) 2000-10-01
AU9633098A (en) 1999-05-10
AR017366A1 (en) 2001-09-05

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