AR007937A1 - A COMPOUND DERIVED FROM BENCIMIDAZOLE, A PROCEDURE FOR PREPARING IT, A MEDICATION CONSTITUTED BY SUCH A COMPOUND AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH A COMPOUND - Google Patents

A COMPOUND DERIVED FROM BENCIMIDAZOLE, A PROCEDURE FOR PREPARING IT, A MEDICATION CONSTITUTED BY SUCH A COMPOUND AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH A COMPOUND

Info

Publication number
AR007937A1
AR007937A1 ARP970103262A ARP970103262A AR007937A1 AR 007937 A1 AR007937 A1 AR 007937A1 AR P970103262 A ARP970103262 A AR P970103262A AR P970103262 A ARP970103262 A AR P970103262A AR 007937 A1 AR007937 A1 AR 007937A1
Authority
AR
Argentina
Prior art keywords
group
compound
hydrogen atom
branched
preparing
Prior art date
Application number
ARP970103262A
Other languages
Spanish (es)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR007937A1 publication Critical patent/AR007937A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto derivado de bencimidazole, de fórmula general (I) en la cual A es un átomo de nitrógeno o un grupo CH,V es un grupo ciclo C4-8 alquilo, ungrupo naftilo o un grupo de fórmula (Y), n es O ó 1, X es un átomo de oxígeno o de azufre, Z es un átomo de nitrógeno o un grupo CH, R1 es un átomo dehidrógeno, un halógeno tal como bromo, cloro o flúor, o un grupo C1-4 alquilo, lineal o ramificado. C1-4 alcoxi, un grupo trifluorometio, un grupo nitro, ungrupo amino, un grupo C1-4 alquilsulfonilamino, un grupo C1-4 di (alquilsulfonil) amino, un grupo C1-4 alquilamino, un grupo C1-4 dialquilamino,un grupo hidroxi o un grupo C1-4 alquilcarbonilamino, R2 es un átomo de hidrógeno, un grupo C1-4 pirrolilo, pirazolilo, isoxazolilo, tiazolilo,piridilo o benzimidazolilo, R4 y R5 representan, independientemente uno de otro un átomo de hidrógeno, un halógeno tal como flúor, cloro o bromo, un grupo C1-4alquilo lineal o ramificado, o un grupo C1-4 alcoxi, un grupo trifluorometilo, R7 es un átomo de hidrógeno o un grupo C1-4 alquilo, lienal o ramificado, enforma de enantiómero, de diastereoisómero, o de mezcla de esas diferentes formas, incluída la mezcla racémica así como sus sales de adición con ácidosfarmacéuticamente aceptables. Además se refiere a un procedimiento para preparar dicho compuesto, a un medicamento constituído por dicho compuesto y auna composición farmacéutica que comprende dicho compuesto. Aplicación terapéutica: los compuestos de la invención son antagonistas de receptoresmuscarinicos M3 y serotininérgicos 5-Ht4.A compound derived from benzimidazole, of general formula (I) in which A is a nitrogen atom or a CH group, V is a C4-8 cycloalkyl group, a naphthyl group or a group of formula (Y), n is O or 1, X is an oxygen or sulfur atom, Z is a nitrogen atom or a CH group, R1 is a hydrogen atom, a halogen such as bromine, chlorine or fluorine, or a C1-4 alkyl group, linear or branched. C1-4 alkoxy, a trifluoromethio group, a nitro group, an amino group, a C1-4 alkylsulfonylamino group, a C1-4 di (alkylsulfonyl) amino group, a C1-4 alkylamino group, a C1-4 dialkylamino group, a hydroxy or a C1-4 alkylcarbonylamino group, R2 is a hydrogen atom, a C1-4 pyrrolyl, pyrazolyl, isoxazolyl, thiazolyl, pyridyl or benzimidazolyl group, R4 and R5 independently of each other represent a hydrogen atom, such a halogen such as fluorine, chlorine or bromine, a linear or branched C1-4alkyl group, or a C1-4 alkoxy group, a trifluoromethyl group, R7 is a hydrogen atom or a C1-4 alkyl, lienal or branched group, as enantiomer, of diastereoisomer, or of mixture of these different forms, including the racemic mixture as well as its addition salts with pharmaceutically acceptable acids. It also refers to a process for preparing said compound, to a drug consisting of said compound and to a pharmaceutical composition comprising said compound. Therapeutic application: the compounds of the invention are antagonists of M3 muscarinic receptors and 5-Ht4 serotinergic receptors.

ARP970103262A 1996-07-25 1997-07-21 A COMPOUND DERIVED FROM BENCIMIDAZOLE, A PROCEDURE FOR PREPARING IT, A MEDICATION CONSTITUTED BY SUCH A COMPOUND AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH A COMPOUND AR007937A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609360A FR2751647B1 (en) 1996-07-25 1996-07-25 BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS

Publications (1)

Publication Number Publication Date
AR007937A1 true AR007937A1 (en) 1999-11-24

Family

ID=9494466

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103262A AR007937A1 (en) 1996-07-25 1997-07-21 A COMPOUND DERIVED FROM BENCIMIDAZOLE, A PROCEDURE FOR PREPARING IT, A MEDICATION CONSTITUTED BY SUCH A COMPOUND AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH A COMPOUND

Country Status (6)

Country Link
AR (1) AR007937A1 (en)
AU (1) AU3853097A (en)
CO (1) CO4890848A1 (en)
FR (1) FR2751647B1 (en)
WO (1) WO1998004546A1 (en)
ZA (1) ZA976619B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771093B1 (en) * 1997-11-19 2000-01-21 Synthelabo IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2000103782A (en) * 1998-07-31 2000-04-11 Kyorin Pharmaceut Co Ltd Cyclic amine derivative and its production
FR2789077A1 (en) * 1999-02-02 2000-08-04 Synthelabo PERAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2805815B1 (en) * 2000-03-01 2002-05-17 Sanofi Synthelabo POLYFLUOROALKYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2805816B1 (en) * 2000-03-01 2002-05-17 Sanofi Synthelabo HALOIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN101016296A (en) 2000-04-28 2007-08-15 阿卡蒂亚药品公司 Muscarinic agonists
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
FR2811989A1 (en) * 2000-07-18 2002-01-25 Sanofi Synthelabo POLYFLUOROALKYTRIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2071497A1 (en) * 1989-12-12 1991-06-13 Andrew William Bridge 2-substituted 4,5-diphenyl-imidazoles
WO1994008577A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4304650A1 (en) * 1993-02-16 1994-08-18 Thomae Gmbh Dr K Condensed 5-membered heterocycles, processes for their preparation and pharmaceutical compositions containing them
WO1996013262A1 (en) * 1994-10-27 1996-05-09 Merck & Co., Inc. Muscarine antagonists

Also Published As

Publication number Publication date
AU3853097A (en) 1998-02-20
FR2751647B1 (en) 1998-09-11
ZA976619B (en) 1998-02-10
CO4890848A1 (en) 2000-02-28
WO1998004546A1 (en) 1998-02-05
FR2751647A1 (en) 1998-01-30

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