AR009523A1 - Derivado de pirimidina 2,4-disustituida, procedimiento para preparar el mismo y una composicion farmaceutica que lo contiene. - Google Patents

Derivado de pirimidina 2,4-disustituida, procedimiento para preparar el mismo y una composicion farmaceutica que lo contiene.

Info

Publication number
AR009523A1
AR009523A1 ARP970104019A ARP970104019A AR009523A1 AR 009523 A1 AR009523 A1 AR 009523A1 AR P970104019 A ARP970104019 A AR P970104019A AR P970104019 A ARP970104019 A AR P970104019A AR 009523 A1 AR009523 A1 AR 009523A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
disorders
disstituted
pirimidine
prepare
Prior art date
Application number
ARP970104019A
Other languages
English (en)
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of AR009523A1 publication Critical patent/AR009523A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un derivado de pirimidina 2,4-disusutituida de la formula (I): donde X es -O- o -NR4-, R1 es H, alquilo inferior, etc, R2 es alquilo inferior, unalquenilo inferior, etc, R3 es H, alquilo inferior, etc, R4 es H, alquilo inferior, R5 es H, alquilo inferior, etc., o halogeno, hidroxi-alquilo inferior, alcoxi inferior-alquilo inferior, etc., R6 es H, alquilo inferior, etc., o hidroxi-alquilo inferior, alcoxi inferior-alquilo inferior, etc., o R5 y R6 secombinan para formar -(CH2)n-(n es 3, 4, 5 o 6), A es heteroarilo sustituido o insustituido o fenilo sustituido o insustituido o una sal de adicion ácidafarmacéuticamente aceptable del mismo, que resultará util en la profilaxis o el tratamiento de los desordenes nerviosos centrales, tales como las enfermedadesrelacionadas con la ansiedad (por ejemplo, neurosis, desordenes somatoformes), depresion, epilepsia o desordenes de los organos circulatorios, tales comoangina de pecho, hipertension y además será de utilidad en la profilaxis o el tratamiento de los desordenes inmuno-neurologicos, tales como la esclerosismultiple y las enfermedades inmuno-inflamatorias, tales como artritis reumatoide.
ARP970104019A 1996-09-04 1997-09-03 Derivado de pirimidina 2,4-disustituida, procedimiento para preparar el mismo y una composicion farmaceutica que lo contiene. AR009523A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25542096 1996-09-04

Publications (1)

Publication Number Publication Date
AR009523A1 true AR009523A1 (es) 2000-04-26

Family

ID=17278521

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104019A AR009523A1 (es) 1996-09-04 1997-09-03 Derivado de pirimidina 2,4-disustituida, procedimiento para preparar el mismo y una composicion farmaceutica que lo contiene.

Country Status (5)

Country Link
AR (1) AR009523A1 (es)
AU (1) AU4134297A (es)
ID (1) ID17076A (es)
WO (1) WO1998009960A1 (es)
ZA (1) ZA977427B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432947B1 (en) 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
JP2002241369A (ja) * 1998-05-18 2002-08-28 Dainippon Pharmaceut Co Ltd ４−ピリミジニルアミノアセトアミド誘導体及びそれを含有する医薬組成物
AU2004200A (en) * 1999-01-14 2000-08-01 Meiji Seika Kaisha Ltd. Poly(adp-ribose) polymerase inhibitors consisting of pyrimidine derivatives
CN1170823C (zh) 1999-11-17 2004-10-13 大日本制药株式会社 [5-氯-6-苯基-2-(4-三氟甲基苯基)-4-嘧啶氨基]乙酰胺衍生物,该衍生物的制备方法、包含该衍生物的药物组合物以及制备这些化合物的中间体
US6525051B2 (en) 2000-03-27 2003-02-25 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
EP2198867A1 (en) 2001-12-07 2010-06-23 Vertex Pharmaceuticals, Inc. Pyrimidine-based compounds useful as GSK-3 inhibitors
US6982259B2 (en) 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
CA2541989C (en) * 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
EP1939181A1 (en) * 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
WO2008116139A2 (en) * 2007-03-22 2008-09-25 Vertex Pharmaceuticals Incorporated N-heterocyclic compounds useful as inhibitors of janus kinases
GB0808664D0 (en) * 2008-05-13 2008-06-18 Syngenta Ltd Chemical compounds
US8691866B2 (en) 2008-12-10 2014-04-08 The General Hospital Corporation HIF inhibitors and use thereof
JP2012529535A (ja) 2009-06-12 2012-11-22 ブリストル−マイヤーズ スクイブ カンパニー キナーゼモジュレーターとして有用なニコチンアミド化合物
EP3887364A1 (en) * 2018-11-30 2021-10-06 Celularity Inc. Aromatic compounds for use in activating hematopoietic stem and progenitor cells
CN115551840A (zh) * 2020-05-19 2022-12-30 优迈特株式会社 含氟嘧啶化合物和含氟嘧啶酮化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0710874A (ja) * 1993-04-28 1995-01-13 Dainippon Pharmaceut Co Ltd ３−（１，２，４−オキサジアゾリル）−５，６，７，８−テトラヒドロ−１，６−ナフチリジン誘導体
JPH07165721A (ja) * 1993-12-15 1995-06-27 Sumitomo Chem Co Ltd 放射性イソキノリンカルボキサミド誘導体

Also Published As

Publication number Publication date
AU4134297A (en) 1998-03-26
ID17076A (id) 1997-12-04
ZA977427B (en) 1998-03-02
WO1998009960A1 (fr) 1998-03-12

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