AR008195A1 - ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES. - Google Patents

ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES.

Info

Publication number
AR008195A1
AR008195A1 ARP970104504A ARP970104504A AR008195A1 AR 008195 A1 AR008195 A1 AR 008195A1 AR P970104504 A ARP970104504 A AR P970104504A AR P970104504 A ARP970104504 A AR P970104504A AR 008195 A1 AR008195 A1 AR 008195A1
Authority
AR
Argentina
Prior art keywords
dab
derivatives
agent
gamma
alpha
Prior art date
Application number
ARP970104504A
Other languages
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR008195A1 publication Critical patent/AR008195A1/en

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  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Acido alfa, gamma-diaminobutírico (DAB) conteniendo derivados oligopetídicos de fórmula R-NH-A en donde: R es un agente de reconocimientode la célula, un agente permieabilizante de la membrana, un agente de localización subcelular o un agente enmascarante; A es un oligopéptidodesprovisto de un grupo amino, que contiene de 1 a 200 aminoácidos es el ácido alfa, gamma-diaminobutírico (DAB), y el grupo carboxilo terminal deloligopéptido se convierte en una amida, amida alquilo inferior, amida dialquilo inferior o hidrazida es de utilidad como portador para la transfección decélulas con un polinucleótido o cualquier otra macromolécula aniónica.Alpha, gamma-diaminobutyric acid (DAB) containing oligopeptide derivatives of the formula R-NH-A where: R is a cell recognition agent, a membrane permieabilizing agent, a subcellular localization agent or a masking agent; A is an oligopeptide devoid of an amino group, containing from 1 to 200 amino acids is alpha, gamma-diaminobutyric acid (DAB), and the terminal carboxyl group of the oligopeptide is converted to an amide, lower alkyl amide, lower dialkyl amide or hydrazide is Useful as a carrier for transfection of cells with a polynucleotide or any other anionic macromolecule.

ARP970104504A 1996-10-02 1997-09-30 ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES. AR008195A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96115784 1996-10-02

Publications (1)

Publication Number Publication Date
AR008195A1 true AR008195A1 (en) 1999-12-09

Family

ID=8223255

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104504A AR008195A1 (en) 1996-10-02 1997-09-30 ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES.

Country Status (6)

Country Link
JP (1) JPH10147595A (en)
AR (1) AR008195A1 (en)
BR (1) BR9704955A (en)
CA (1) CA2213257A1 (en)
MX (1) MX9707319A (en)
TR (1) TR199701091A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001323059A (en) * 2000-05-18 2001-11-20 Hisamitsu Pharmaceut Co Inc Polypeptide derivative and carrier for nucleic acid

Also Published As

Publication number Publication date
TR199701091A3 (en) 1998-04-21
JPH10147595A (en) 1998-06-02
CA2213257A1 (en) 1998-04-02
BR9704955A (en) 1998-10-27
TR199701091A2 (en) 1998-04-21
MX9707319A (en) 1998-04-30

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