KR850002986A - Method for preparing 2-dioxacycloalkylthiophenem derivative - Google Patents

Method for preparing 2-dioxacycloalkylthiophenem derivative Download PDF

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Publication number
KR850002986A
KR850002986A KR1019840006346A KR840006346A KR850002986A KR 850002986 A KR850002986 A KR 850002986A KR 1019840006346 A KR1019840006346 A KR 1019840006346A KR 840006346 A KR840006346 A KR 840006346A KR 850002986 A KR850002986 A KR 850002986A
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KR
South Korea
Prior art keywords
methylene
hydrogen
ylmethyl
compound
dioxacyclopent
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KR1019840006346A
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Korean (ko)
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KR870000524B1 (en
Inventor
자이키 하마나카 에른스트
Original Assignee
죤 에이. 밸코 스키
화이자 인코포레이티드
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Publication of KR850002986A publication Critical patent/KR850002986A/en
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Publication of KR870000524B1 publication Critical patent/KR870000524B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

내용 없음No content

Description

2-디옥사시클로알킬티오페넴 유도체의 제조방법Method for preparing 2-dioxacycloalkylthiophenem derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (9)

다음 일반식(A)의 화합물을 가수소 분해시켜 상응하는 일반식(Ⅰ) 화합물로 전환시킴을 특징으로 하여 다음 일반식(Ⅰ) 화합물 또는 약학적으로 허용되는 이의 염의 제조하는 방법.A process for preparing the following compound of formula (I) or a pharmaceutically acceptable salt thereof, characterized in that the compound of formula (A) is subjected to hydrogenolysis to convert to the corresponding compound of formula (I). 상기식에서, R은[여기에서, A는 카보닐, 티오카보닐 또는 메틸렌이고, B는 탄소수 2내지 5의 알킬렌이고 alk는 탄수소 1 내지 6의 알킬렌이고, n은 0 또는 1이다]이고, R1은 수소이거나 생체내에서 가수분해가능한 에스테르 형성 그룹이고, R3는 가수소분해시 제거되는 카복실산 보호 그룹이다.Wherein R is [Wherein A is carbonyl, thiocarbonyl or methylene, B is alkylene having 2 to 5 carbon atoms and alk is alkylene having 1 to 6 carbon atoms, n is 0 or 1] and R 1 is It is hydrogen or an ester forming group hydrolyzable in vivo, and R 3 is a carboxylic acid protecting group which is removed upon hydrogenolysis. 제1항에 있어서, R1이 수소, B가 에틸렌, A가 메틸렌, m은 1이고 alk가 메틸렌인 방법.The process of claim 1 wherein R 1 is hydrogen, B is ethylene, A is methylene, m is 1 and alk is methylene. 제2항에 있어서, R이 1,3-디옥사시클로펜트-4-일메틸 또는 1,3-디옥사시클로-2-펜트일메틸인 방법.The method of claim 2, wherein R is 1,3-dioxacyclopent-4-ylmethyl or 1,3-dioxacyclo-2-pentylmethyl. 제1항에 있어서, R1이 수소, A가 카보닐, m이 1이거나 alk가 메틸렌인 방법.The process of claim 1 wherein R 1 is hydrogen, A is carbonyl, m is 1 or alk is methylene. 제4항에 있어서, R이 2-옥소-1,3-디옥사시클로펜트-4-일메틸인 방법.The method of claim 4, wherein R is 2-oxo-1,3-dioxacyclopent-4-ylmethyl. 제1항에 있어서, R1이 수소, B가 프로필렌, A가 메틸렌 또는 카보닐이고 n이 0인 방법.2. The process of claim 1 wherein R 1 is hydrogen, B is propylene, A is methylene or carbonyl and n is 0. 제6항에 있어서, R이 1,3-디옥사시클로헥스-2-일 또는 2-옥소-1,3-디옥사시클로헥스-5-일인 방법.The method of claim 6, wherein R is 1,3-dioxacyclohex-2-yl or 2-oxo-1,3-dioxacyclohex-5-yl. 제1항에 있어서, 일반식(Ⅰ) 화합물이 하기 화합물 또는 약학적으로 허용되는 이의 염인 방법.The method according to claim 1, wherein the compound of general formula (I) is the following compound or a pharmaceutically acceptable salt thereof. 상기식에서, R은[여기서, A는 카보닐, 티오카보닐 또는 메틸렌이고 B는 탄소수 2 내지 5의 알킬렌이고, alk는 탄소수 1 내지 6의 알킬렌이고, n은 0 또는 1 이다]이고, R1은 수소이거나 생체내에서 가수분해 에스테르 형성그룹이다.Wherein R is Wherein A is carbonyl, thiocarbonyl or methylene, B is alkylene of 2 to 5 carbon atoms, alk is alkylene of 1 to 6 carbon atoms, n is 0 or 1] and R 1 is hydrogen Hydrolyzed ester forming group in vivo. 제8항에 있어서, R1이 수소이고 R이 1,3-디옥사시클로펜트-4-일메틸, 1,3-디옥사시클로펜트-2-일메틸, 2-옥소-1,3-디옥사시클로펜트-4-일메틸, 1,3-디옥사시클로헥스-5-일 또는 2-옥소-1,3 디옥사시클로 헥스-5-일인 방법.The compound of claim 8, wherein R 1 is hydrogen and R is 1,3-dioxacyclopent-4-ylmethyl, 1,3-dioxacyclopent-2-ylmethyl, 2-oxo-1,3-di Oxcyclopent-4-ylmethyl, 1,3-dioxacyclohex-5-yl or 2-oxo-1,3 dioxacyclo hex-5-yl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840006346A 1983-10-14 1984-10-13 Process for preparing 2-dioxacycloalkyl thiopenem derivatives KR870000524B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54185483A 1983-10-14 1983-10-14
US541,854 1983-10-14
US541854 1995-10-10

Publications (2)

Publication Number Publication Date
KR850002986A true KR850002986A (en) 1985-05-28
KR870000524B1 KR870000524B1 (en) 1987-03-14

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KR1019840006346A KR870000524B1 (en) 1983-10-14 1984-10-13 Process for preparing 2-dioxacycloalkyl thiopenem derivatives

Country Status (14)

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JP (1) JPS60109589A (en)
KR (1) KR870000524B1 (en)
DD (1) DD232706A5 (en)
EG (1) EG16841A (en)
ES (1) ES8700858A1 (en)
FI (1) FI81355C (en)
HU (1) HU192593B (en)
NO (1) NO844091L (en)
PH (1) PH19986A (en)
PL (1) PL145185B1 (en)
PT (1) PT79345B (en)
SU (1) SU1319786A3 (en)
YU (1) YU43937B (en)
ZA (1) ZA847980B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4656312B2 (en) * 2005-09-13 2011-03-23 信越化学工業株式会社 Nonaqueous electrolytic solution, secondary battery and capacitor containing cyclic carbonate-modified organosilicon compound

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Publication number Publication date
JPS60109589A (en) 1985-06-15
HUT35265A (en) 1985-06-28
PH19986A (en) 1986-08-28
FI81355C (en) 1990-10-10
HU192593B (en) 1987-06-29
EG16841A (en) 1993-04-30
FI844024L (en) 1985-04-15
YU175184A (en) 1987-02-28
FI844024A0 (en) 1984-10-12
PL145185B1 (en) 1988-08-31
FI81355B (en) 1990-06-29
DD232706A5 (en) 1986-02-05
PL250030A1 (en) 1985-06-18
ZA847980B (en) 1986-05-28
NO844091L (en) 1985-04-15
ES536686A0 (en) 1986-11-16
JPH0369352B2 (en) 1991-10-31
SU1319786A3 (en) 1987-06-23
YU43937B (en) 1989-12-31
ES8700858A1 (en) 1986-11-16
PT79345A (en) 1984-11-01
KR870000524B1 (en) 1987-03-14
PT79345B (en) 1986-11-20

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