TR199701091A2 - Alpha, gamma-Diaminobutyric acid (DAB) containing oligopeptide derivatives - Google Patents

Alpha, gamma-Diaminobutyric acid (DAB) containing oligopeptide derivatives

Info

Publication number
TR199701091A2
TR199701091A2 TR97/01091A TR9701091A TR199701091A2 TR 199701091 A2 TR199701091 A2 TR 199701091A2 TR 97/01091 A TR97/01091 A TR 97/01091A TR 9701091 A TR9701091 A TR 9701091A TR 199701091 A2 TR199701091 A2 TR 199701091A2
Authority
TR
Turkey
Prior art keywords
dab
alpha
gamma
agent
diaminobutyric acid
Prior art date
Application number
TR97/01091A
Other languages
Turkish (tr)
Other versions
TR199701091A3 (en
Inventor
Legendre Jean-Yves
Supersaxo Andreas
Trzeciak Arnold
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199701091A3 publication Critical patent/TR199701091A3/en
Publication of TR199701091A2 publication Critical patent/TR199701091A2/en

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

Asagidaki formülün oligopeptid türevlerini içeren alfa, gama-Diaminobutirik asit (DAB) R'-NH-A burada R' bir hücre tanima maddesi, bir zargeçirgenlik maddesi, bir alt hücresel yerlestirme maddesi ya da maskeleme maddesidir; A bir amino grubunun bir oligopeptid devoididir ve 1 ila 200 amino asit içerir, burada amino asitlerin en azindan biri alfa, gamadiaminobutirik asittir (DAB) ve olipeptidin terminal karboksi grubu bir amide, düsük alkil amide, di-düsük alkil amide ya da hidrazide dönüstürülür, hücrelerin bir polinükleotid ya da herhangi bir anyonik makromolekül ile transfeksiyonu için bir tasiyici olarak yararlidir.Alpha, gamma-Diaminobutyric acid (DAB) R'-NH-A containing the oligopeptide derivatives of the formula below wherein R 'is a cell recognition agent, a cellular agent, a subcellular placement agent or masking agent; A is an oligopeptide devoid of an amino group and contains 1 to 200 amino acids, where at least one of the amino acids is alpha, gamadiaminobutyric acid (DAB), and the terminal carboxy group of the olipeptide is converted to an amide, lower alkyl amide, di-lower alkyl amide or hydrazide, It is useful as a carrier for transfection of cells with a polynucleotide or any anionic macromolecule.

TR97/01091A 1996-10-02 1997-10-02 Alpha, gamma-Diaminobutyric acid (DAB) containing oligopeptide derivatives TR199701091A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96115784 1996-10-02

Publications (2)

Publication Number Publication Date
TR199701091A3 TR199701091A3 (en) 1998-04-21
TR199701091A2 true TR199701091A2 (en) 1998-04-21

Family

ID=8223255

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/01091A TR199701091A2 (en) 1996-10-02 1997-10-02 Alpha, gamma-Diaminobutyric acid (DAB) containing oligopeptide derivatives

Country Status (6)

Country Link
JP (1) JPH10147595A (en)
AR (1) AR008195A1 (en)
BR (1) BR9704955A (en)
CA (1) CA2213257A1 (en)
MX (1) MX9707319A (en)
TR (1) TR199701091A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001323059A (en) * 2000-05-18 2001-11-20 Hisamitsu Pharmaceut Co Inc Polypeptide derivative and carrier for nucleic acid

Also Published As

Publication number Publication date
TR199701091A3 (en) 1998-04-21
JPH10147595A (en) 1998-06-02
CA2213257A1 (en) 1998-04-02
BR9704955A (en) 1998-10-27
AR008195A1 (en) 1999-12-09
MX9707319A (en) 1998-04-30

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