AR003967A1 - (22R) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-OXO-4-AZA-5ALFA- ANDROST-1-ENO-17BETA-CARBOXAMIDE EPIMERES, A PROCESS FOR YOUR PREPARATION AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND THEM. - Google Patents

(22R) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-OXO-4-AZA-5ALFA- ANDROST-1-ENO-17BETA-CARBOXAMIDE EPIMERES, A PROCESS FOR YOUR PREPARATION AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND THEM.

Info

Publication number
AR003967A1
AR003967A1 ARP960103652A AR10365296A AR003967A1 AR 003967 A1 AR003967 A1 AR 003967A1 AR P960103652 A ARP960103652 A AR P960103652A AR 10365296 A AR10365296 A AR 10365296A AR 003967 A1 AR003967 A1 AR 003967A1
Authority
AR
Argentina
Prior art keywords
17beta
androst
phenylprop
aza
carboxamide
Prior art date
Application number
ARP960103652A
Other languages
Spanish (es)
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of AR003967A1 publication Critical patent/AR003967A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a los epímeros:(22R)-N-(1,1,1-trifluoro-2- fenilprop-2-il)-3-oxo-4-aza-5alfa-androst-1-eno-17beta-carboxamida, y (22S)-N-(1,1,1-trifluoro-2-fenilprop-2-il)-3-oxo-4-aza-5alfa-androst-1-eno-17beta- carboxamida, útiles como inhibidores de la enzima 5-reductasa de testosterona,procesos para su preparación y composiciones farmacéuticas que los contienen. Dichos epímeros responden a las fórmulas (I) y (II).The present invention relates to the epimers: (22R) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5alpha-androst-1-ene-17beta -carboxamide, and (22S) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide, useful as testosterone 5-reductase enzyme inhibitors, processes for their preparation and pharmaceutical compositions containing them. Said epimers respond to formulas (I) and (II).

ARP960103652A 1995-07-21 1996-07-19 (22R) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-OXO-4-AZA-5ALFA- ANDROST-1-ENO-17BETA-CARBOXAMIDE EPIMERES, A PROCESS FOR YOUR PREPARATION AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND THEM. AR003967A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (en) 1995-07-21 1995-07-21 EPIMERS OF (22RS) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-BONE -4-AZA-5ALFA-ANDROST-1-ENE-17BETA-CARBOSSAMIDE

Publications (1)

Publication Number Publication Date
AR003967A1 true AR003967A1 (en) 1998-09-30

Family

ID=11372032

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103652A AR003967A1 (en) 1995-07-21 1996-07-19 (22R) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-OXO-4-AZA-5ALFA- ANDROST-1-ENO-17BETA-CARBOXAMIDE EPIMERES, A PROCESS FOR YOUR PREPARATION AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTAND THEM.

Country Status (17)

Country Link
EP (1) EP0782582A1 (en)
JP (1) JPH10506411A (en)
KR (1) KR970706298A (en)
CN (1) CN1159195A (en)
AR (1) AR003967A1 (en)
AU (1) AU6418396A (en)
BR (1) BR9606527A (en)
CA (1) CA2199273A1 (en)
EA (1) EA199700045A1 (en)
HU (1) HUP9702465A3 (en)
IL (1) IL120343A0 (en)
IT (1) IT1275594B1 (en)
MX (1) MX9701948A (en)
NO (1) NO971196L (en)
PL (1) PL319351A1 (en)
WO (1) WO1997004002A1 (en)
ZA (1) ZA965678B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6137399A (en) * 1998-09-09 2000-03-27 Merck & Co., Inc. Method of determining and reducing the risk of bph-related urologic events
DE60018707T2 (en) * 1999-01-25 2006-02-09 Smithkline Beecham Corp. ANTI-ANDROGENES AND METHOD FOR THE TREATMENT OF DISEASES
CN100355772C (en) * 2005-12-28 2007-12-19 天津大学 Steroid compound with 5-alpha reductase active and preparation process thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
NO971196D0 (en) 1997-03-14
AU6418396A (en) 1997-02-18
CA2199273A1 (en) 1997-02-06
PL319351A1 (en) 1997-08-04
WO1997004002A1 (en) 1997-02-06
ITMI951587A0 (en) 1995-07-21
ITMI951587A1 (en) 1997-01-21
HUP9702465A3 (en) 1998-11-30
NO971196L (en) 1997-03-14
HUP9702465A2 (en) 1998-05-28
EA199700045A1 (en) 1997-12-30
BR9606527A (en) 1997-12-23
EP0782582A1 (en) 1997-07-09
MX9701948A (en) 1997-06-28
JPH10506411A (en) 1998-06-23
CN1159195A (en) 1997-09-10
IT1275594B1 (en) 1997-08-06
KR970706298A (en) 1997-11-03
ZA965678B (en) 1997-01-24
IL120343A0 (en) 1997-06-10

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