NO971196L - Epimers of (22RS) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5-alpha> -androst-1-en-17 carboxamide - Google Patents

Epimers of (22RS) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5-alpha> -androst-1-en-17 carboxamide

Info

Publication number
NO971196L
NO971196L NO971196A NO971196A NO971196L NO 971196 L NO971196 L NO 971196L NO 971196 A NO971196 A NO 971196A NO 971196 A NO971196 A NO 971196A NO 971196 L NO971196 L NO 971196L
Authority
NO
Norway
Prior art keywords
androst
phenylprop
aza
carboxamide
trifluoro
Prior art date
Application number
NO971196A
Other languages
Norwegian (no)
Other versions
NO971196D0 (en
Inventor
Achille Panzeri
Marcella Nesi
Enrico Di Salle
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO971196L publication Critical patent/NO971196L/en
Publication of NO971196D0 publication Critical patent/NO971196D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Epimerene: (22R)-N-(l,l,l-trifluor-2-fenylprop-2-yl)-3-okso-4-aza-5 a-androst-l-en- 17 C-karboksamid og (22S)-N-(l,l,l-trifluor-2-fenylprop-2-yl)-3-okso-4-aza-5 a- androst-l-en-17 C-karboksamid, som er nyttige som inhibitorer av testosteron-5 a- reductaseenzym, en fremgangsmåte for deres fremstilling og farmasøytiske preparater inneholdende forbindelsene.Epimers: (22R) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5α-androst-1-ene-17C-carboxamide and (22S) ) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5α-androst-1-ene-17C-carboxamide, which are useful as inhibitors of testosterone-5α-reductase enzyme, a process for their preparation and pharmaceutical compositions containing the compounds.

NO971196A 1995-07-21 1997-03-14 Epimers of (22RS) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5-alpha> -androst-1-en-17 carboxamide NO971196D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (en) 1995-07-21 1995-07-21 EPIMERS OF (22RS) -N- (1,1,1-TRIFLUORO-2-PHENYLPROP-2-IL) -3-BONE -4-AZA-5ALFA-ANDROST-1-ENE-17BETA-CARBOSSAMIDE
PCT/EP1996/002830 WO1997004002A1 (en) 1995-07-21 1996-06-28 EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5α-ANDROST-1-ENE-17β-CARBOXAMIDE

Publications (2)

Publication Number Publication Date
NO971196L true NO971196L (en) 1997-03-14
NO971196D0 NO971196D0 (en) 1997-03-14

Family

ID=11372032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971196A NO971196D0 (en) 1995-07-21 1997-03-14 Epimers of (22RS) -N- (1,1,1-trifluoro-2-phenylprop-2-yl) -3-oxo-4-aza-5-alpha> -androst-1-en-17 carboxamide

Country Status (17)

Country Link
EP (1) EP0782582A1 (en)
JP (1) JPH10506411A (en)
KR (1) KR970706298A (en)
CN (1) CN1159195A (en)
AR (1) AR003967A1 (en)
AU (1) AU6418396A (en)
BR (1) BR9606527A (en)
CA (1) CA2199273A1 (en)
EA (1) EA199700045A1 (en)
HU (1) HUP9702465A3 (en)
IL (1) IL120343A0 (en)
IT (1) IT1275594B1 (en)
MX (1) MX9701948A (en)
NO (1) NO971196D0 (en)
PL (1) PL319351A1 (en)
WO (1) WO1997004002A1 (en)
ZA (1) ZA965678B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013509A1 (en) * 1998-09-09 2000-03-16 Merck & Co., Inc. Method of determining and reducing the risk of bph-related urologic events
ES2237408T3 (en) * 1999-01-25 2005-08-01 Smithkline Beecham Corporation ANTIANDROGENS AND PROCEDURES TO TREAT AN ILLNESS.
CN100355772C (en) * 2005-12-28 2007-12-19 天津大学 Steroid compound with 5-alpha reductase active and preparation process thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
HUP9702465A2 (en) 1998-05-28
EP0782582A1 (en) 1997-07-09
HUP9702465A3 (en) 1998-11-30
ITMI951587A1 (en) 1997-01-21
CA2199273A1 (en) 1997-02-06
ZA965678B (en) 1997-01-24
AU6418396A (en) 1997-02-18
JPH10506411A (en) 1998-06-23
AR003967A1 (en) 1998-09-30
IL120343A0 (en) 1997-06-10
ITMI951587A0 (en) 1995-07-21
BR9606527A (en) 1997-12-23
EA199700045A1 (en) 1997-12-30
KR970706298A (en) 1997-11-03
IT1275594B1 (en) 1997-08-06
CN1159195A (en) 1997-09-10
NO971196D0 (en) 1997-03-14
PL319351A1 (en) 1997-08-04
WO1997004002A1 (en) 1997-02-06
MX9701948A (en) 1997-06-28

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