AR002281A1 - Compuesto antimigrana derivado del 1,2,5-tiadiazol de las indolilalquil- piridinil y pirimidinil-piperazina, composicion farmaceutica que lo contiene - Google Patents

Compuesto antimigrana derivado del 1,2,5-tiadiazol de las indolilalquil- piridinil y pirimidinil-piperazina, composicion farmaceutica que lo contiene

Info

Publication number
AR002281A1
AR002281A1 ARP960101598A AR10159896A AR002281A1 AR 002281 A1 AR002281 A1 AR 002281A1 AR P960101598 A ARP960101598 A AR P960101598A AR 10159896 A AR10159896 A AR 10159896A AR 002281 A1 AR002281 A1 AR 002281A1
Authority
AR
Argentina
Prior art keywords
tiadiazole
antimigrane
pirimidinyl
piridinyl
indolylalkyl
Prior art date
Application number
ARP960101598A
Other languages
English (en)
Spanish (es)
Inventor
R R Crenshaw
E H Ruediger
D W Smith
C Solomon
J P Yevich
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR002281A1 publication Critical patent/AR002281A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP960101598A 1995-03-02 1996-03-01 Compuesto antimigrana derivado del 1,2,5-tiadiazol de las indolilalquil- piridinil y pirimidinil-piperazina, composicion farmaceutica que lo contiene AR002281A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/396,825 US5618816A (en) 1995-03-02 1995-03-02 Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines

Publications (1)

Publication Number Publication Date
AR002281A1 true AR002281A1 (es) 1998-03-11

Family

ID=23568771

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101598A AR002281A1 (es) 1995-03-02 1996-03-01 Compuesto antimigrana derivado del 1,2,5-tiadiazol de las indolilalquil- piridinil y pirimidinil-piperazina, composicion farmaceutica que lo contiene

Country Status (17)

Country Link
US (1) US5618816A (enExample)
EP (1) EP0729958A2 (enExample)
JP (1) JPH08253479A (enExample)
KR (1) KR960034200A (enExample)
CN (1) CN1063177C (enExample)
AR (1) AR002281A1 (enExample)
AU (1) AU707770B2 (enExample)
CA (1) CA2169804A1 (enExample)
CZ (1) CZ46896A3 (enExample)
HU (1) HUP9600498A3 (enExample)
IL (1) IL117224A (enExample)
NO (1) NO305248B1 (enExample)
NZ (1) NZ286090A (enExample)
PL (1) PL313022A1 (enExample)
RU (1) RU2165420C2 (enExample)
TW (1) TW331558B (enExample)
ZA (1) ZA961392B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807857A (en) * 1994-05-19 1998-09-15 Merck Sharp & Dohme Ltd. Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
ATE546134T1 (de) * 2002-12-26 2012-03-15 Pozen Inc Mehrschichtige dosierformen enthaltend naproxen und triptane
WO2004110492A2 (en) * 2003-06-06 2004-12-23 Glaxo Group Limited Composition comprising triptans and nsaids
RU2329044C1 (ru) * 2006-11-16 2008-07-20 Андрей Александрович Иващенко Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
FI76795C (fi) * 1979-09-04 1988-12-12 Bristol Myers Co Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter.
US4600779A (en) * 1982-03-29 1986-07-15 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
US5151435A (en) * 1991-04-08 1992-09-29 Merck & Co., Inc. Angiotensin ii antagonists incorporating an indole or dihydroindole
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5807857A (en) * 1994-05-19 1998-09-15 Merck Sharp & Dohme Ltd. Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
NO305248B1 (no) 1999-04-26
CN1063177C (zh) 2001-03-14
NO960699L (no) 1996-09-03
HU9600498D0 (en) 1996-04-29
PL313022A1 (en) 1996-09-16
IL117224A0 (en) 1996-06-18
AU4581996A (en) 1996-09-12
TW331558B (en) 1998-05-11
CN1138042A (zh) 1996-12-18
US5618816A (en) 1997-04-08
HUP9600498A2 (en) 1997-10-28
EP0729958A3 (enExample) 1996-10-02
KR960034200A (ko) 1996-10-22
RU2165420C2 (ru) 2001-04-20
ZA961392B (en) 1997-08-21
AU707770B2 (en) 1999-07-22
EP0729958A2 (en) 1996-09-04
HUP9600498A3 (en) 1998-10-28
CA2169804A1 (en) 1996-09-03
NO960699D0 (no) 1996-02-22
IL117224A (en) 2000-06-29
NZ286090A (en) 1997-12-19
JPH08253479A (ja) 1996-10-01
CZ46896A3 (en) 1996-09-11

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