AP883A - Synthetic IL-10 analogues. - Google Patents
Synthetic IL-10 analogues. Download PDFInfo
- Publication number
- AP883A AP883A APAP/P/1998/001295A AP9801295A AP883A AP 883 A AP883 A AP 883A AP 9801295 A AP9801295 A AP 9801295A AP 883 A AP883 A AP 883A
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- Prior art keywords
- polypeptide
- amino acid
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- arg
- lys
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- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK1996/000029 WO1997026278A1 (en) | 1996-01-18 | 1996-01-18 | Synthetic il-10 analogues |
| PCT/DK1997/000021 WO1997026279A1 (en) | 1996-01-18 | 1997-01-16 | Synthetic il-10 analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9801295A0 AP9801295A0 (en) | 1998-09-30 |
| AP883A true AP883A (en) | 2000-10-25 |
Family
ID=8155499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1998/001295A AP883A (en) | 1996-01-18 | 1997-01-16 | Synthetic IL-10 analogues. |
Country Status (14)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997026278A1 (en) * | 1996-01-18 | 1997-07-24 | Steeno Research Group A/S | Synthetic il-10 analogues |
| AU6887096A (en) * | 1996-09-11 | 1998-04-02 | Patrick T. Prendergast | Immune direction therapy |
| CA2316296A1 (en) * | 1997-10-10 | 1999-04-22 | Imperial College Of Science, Technology And Medicine | Use of csaidtm compounds for the management of uterine contractions |
| DE19851675A1 (de) * | 1998-11-10 | 2000-05-11 | Bayer Ag | Menschliche Interleukin-10 Mutantenproteine |
| US6685931B1 (en) | 1998-12-22 | 2004-02-03 | Schering Corporation | Treatment of hepatitis C virus infections with interleukin-10 |
| WO2001068130A1 (en) * | 2000-03-14 | 2001-09-20 | National Jewish Medical And Research Center | Method and composition for treating airway hyperresponsiveness |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US6797722B2 (en) * | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
| RU2260598C2 (ru) * | 2003-10-29 | 2005-09-20 | Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ | Пептид, обладающий способностью ингибировать миграцию моноцитарных клеток, стимулированную белком мср-1 |
| GB0500643D0 (en) * | 2005-01-13 | 2005-02-23 | Renovo Ltd | Medicaments |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN101730708B (zh) | 2007-03-28 | 2013-09-18 | 哈佛大学校长及研究员协会 | 缝合多肽 |
| AU2014201269B2 (en) * | 2008-02-08 | 2016-09-15 | Aileron Therapeutics, Inc. | Therapeutic peptidomimetic macrocycles |
| GB2471588A (en) * | 2008-02-08 | 2011-01-05 | Aileron Therapeutics Inc | Therapeutic peptidomimetic macrocycles |
| RU2639523C2 (ru) | 2011-10-18 | 2017-12-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы и их применение |
| CN104159595A (zh) | 2012-02-15 | 2014-11-19 | 爱勒让治疗公司 | 拟肽大环化合物 |
| CN104144695A (zh) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| US10471120B2 (en) | 2014-09-24 | 2019-11-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
| JP2020508436A (ja) | 2016-12-07 | 2020-03-19 | プロジェニティ， インコーポレイテッド | 胃腸管の検出方法、装置およびシステム |
| US11596670B2 (en) | 2017-03-30 | 2023-03-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with IL-10 or an IL-10 agonist |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| BR102019007044A2 (pt) * | 2019-04-05 | 2021-12-28 | Universidade Federal de Uberlândia | Peptídeos sintéticos com afinidade ao receptor de interleucina-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0405980A1 (en) * | 1989-06-28 | 1991-01-02 | Schering Corporation | Cytokine synthesis inhibitory factor, antagonists thereof, and methods of using same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5624823A (en) * | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
| EP0629130A1 (en) * | 1992-03-04 | 1994-12-21 | Schering Corporation | Use of interleukin-10 to suppress graft-vs.-host disease |
| RU2051922C1 (ru) * | 1992-06-19 | 1996-01-10 | Людмила Яковлевна Соловьева | СПОСОБ ВЫДЕЛЕНИЯ РЕКОМБИНАНТНОГО ИНТЕРЛЕЙКИНА - 1β ИЗ БИОМАССЫ МИКРООРГАНИЗМОВ |
| CA2085291A1 (en) | 1992-07-30 | 1994-01-31 | Martin L. Breitman | Novel receptor tyrosine kinase |
| US5328989A (en) * | 1993-03-05 | 1994-07-12 | Schering-Plough | Purification of human interleukin-10 from a cell culture medium |
| US5446128A (en) | 1993-06-18 | 1995-08-29 | The Board Of Trustees Of The University Of Illinois | Alpha-helix mimetics and methods relating thereto |
| CZ23396A3 (en) | 1993-07-26 | 1996-05-15 | Schering Corp | Antagonists and agonists of human interleukin-10 |
| DK0769054T3 (da) * | 1994-07-05 | 2000-11-13 | Steeno Res Group As | Immunmodulatorer |
| US5654276A (en) * | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| WO1997026278A1 (en) * | 1996-01-18 | 1997-07-24 | Steeno Research Group A/S | Synthetic il-10 analogues |
-
1996
- 1996-01-18 WO PCT/DK1996/000029 patent/WO1997026278A1/en active Application Filing
- 1996-01-18 AU AU43856/96A patent/AU4385696A/en not_active Abandoned
-
1997
- 1997-01-06 ZA ZA9700084A patent/ZA9784B/xx unknown
- 1997-01-16 AP APAP/P/1998/001295A patent/AP883A/en active
- 1997-01-16 KR KR1019980705491A patent/KR19990077344A/ko not_active Ceased
- 1997-01-16 JP JP9525609A patent/JP2000503652A/ja not_active Ceased
- 1997-01-16 EP EP97900549A patent/EP0879245A1/en not_active Withdrawn
- 1997-01-16 CA CA002243275A patent/CA2243275A1/en not_active Abandoned
- 1997-01-16 BR BR9707036-0A patent/BR9707036A/pt not_active Application Discontinuation
- 1997-01-16 RU RU98115293/04A patent/RU2194054C2/ru not_active IP Right Cessation
- 1997-01-16 US US09/101,825 patent/US6936586B1/en not_active Expired - Fee Related
- 1997-01-16 CN CN97193092A patent/CN1226899A/zh active Pending
- 1997-01-16 PL PL97327928A patent/PL327928A1/xx unknown
- 1997-01-16 AU AU13011/97A patent/AU718476B2/en not_active Ceased
- 1997-01-16 WO PCT/DK1997/000021 patent/WO1997026279A1/en not_active Application Discontinuation
- 1997-01-17 AR ARP970100194A patent/AR006517A1/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0405980A1 (en) * | 1989-06-28 | 1991-01-02 | Schering Corporation | Cytokine synthesis inhibitory factor, antagonists thereof, and methods of using same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997026278A1 (en) | 1997-07-24 |
| AP9801295A0 (en) | 1998-09-30 |
| KR19990077344A (ko) | 1999-10-25 |
| CN1226899A (zh) | 1999-08-25 |
| EP0879245A1 (en) | 1998-11-25 |
| BR9707036A (pt) | 1999-08-31 |
| AU1301197A (en) | 1997-08-11 |
| RU2194054C2 (ru) | 2002-12-10 |
| WO1997026279A1 (en) | 1997-07-24 |
| JP2000503652A (ja) | 2000-03-28 |
| PL327928A1 (en) | 1999-01-04 |
| US6936586B1 (en) | 2005-08-30 |
| ZA9784B (en) | 1997-07-17 |
| CA2243275A1 (en) | 1997-07-24 |
| AU718476B2 (en) | 2000-04-13 |
| AR006517A1 (es) | 1999-09-08 |
| AU4385696A (en) | 1997-08-11 |
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