AP799A - Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl) phenylalkyl]-azaheterocyclylamide compounds. - Google Patents

Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl) phenylalkyl]-azaheterocyclylamide compounds. Download PDF

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AP799A
AP799A APAP/P/1997/001144A AP9701144A AP799A AP 799 A AP799 A AP 799A AP 9701144 A AP9701144 A AP 9701144A AP 799 A AP799 A AP 799A
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oxopyrrolidin
aminoiminomethyl
benzyl
trifiuoroacetate
amide
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APAP/P/1997/001144A
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AP9701144A0 (en
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William R Ewing
Michael R Becker
Yong Mi Choi-Sledeski
Heinry W Pauls
Alfred P Spada
Daniel L Cheney
Jonathan Stephen Mason
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Aventis Pharmaceuticals Products Inc
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

The compounds of formula (I) exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula (I) , compositions containing compounds of formula (I) , and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

Description

SUBSTITUTED (SULFINIC ACID, SULFONIC ACID. SULFONYLAMINO OR SULFINYLAMINO) N-i(AMINOIMINOMETHYL)PHENYLALKYL)-
AZAHETEROCYCLYLAMIDE COMPOUNDS
This application is a continuation-in-part of U.S. patent application Serial No. 08/481,024, filed June 7, 1995.
Field of the Invention
The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
Factor Xa is the penultimate enzyme in the coagulation cascade. Both free factor Xa and factor Xa assembled in the prothrombinase complex (Factor Xa, Factor Va, calcium and phospholipid) are inhibited by compounds of formula I. Factor Xa inhibition is obtained by direct complex formation between the inhibitor and the enzyme and is therefore independent of the plasma cofactor antithrombin III. Effective factor Xa inhibition is achieved by administering the compounds either by oral administration, continuous intravenous infusion, bolus intravenous administration or any other parenteral route such that it achieves the desired effect of preventing the factor Xa induced formation of thrombin from prothrombin.
Anticoagulant therapy is indicated for the treatment and prophylaxis of a variety of thrombotic conditions of both the venous and arterial vasculature. In the arterial system, abnormal thrombus formation is primarily associated with arteries of the coronary, cerebral and peripheral vasculature. The diseases associated with thrombotic occlusion of these vessels principally include acute myocardial infarction (AMI), unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy and percutaneous transluminal coronary angioplasty (PTCA), transient ischemic attacks, stroke, intermittent claudication and bypass grafting of the coronary (CABG) or peripheral arteries. Chronic anticoagulant therapy may also be beneficial in preventing the vessel luminal narrowing (restenosis) that often occurs following PTCA and CABG, and in the maintenance of vascular access patency in long-term hemodialysis patients. With respect to the venous vasculature, pathologic thrombus formation frequently occurs in the veins of the lower extremities following abdominal, knee and hip surgery (deep vein thrombosis, DVT). DVT further predisposes the patient to a higher risk of pulmonary thromboembolism. A systemic, disseminated intravascular coagulopathy (DIC) commonly occurs in both vascular systems during septic shock, certain viral infections and cancer. This condition is characterized by a rapid consumption of coagulation factors and their plasma inhibitors resulting in the formation of life-threatening thrombin throughout the microvasculature of several organ systems.· The indications discussed above include some, but not all, of the possible clinical situations where anticoagulant therapy is warranted. Those experienced in this field are well aware of the circumstances requiring either acute or chronic prophylactic anticoagulant therapy.
SUMMARY OF THE INVENTION
This invention is directed to the pharmaceutical use of a compound of formula I below for treating a patient suffering from a physiological disorder capable of being modulated by inhibiting an activity of Factor Xa, where formula I is as follows:
is phenyl or monocyclic heteroaryl; R is hydrogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted heteroaralkyl or hydroxyalkyl;
Rn is hydrogen, R3S(O)P- or R3R4NS(O)p-;
Rj is hydrogen, or when Xs and X5. taken together are =NRS, then R2 is hydrogen, optionally substituted lower alkyl, optionally substituted aralkyl or optionally substituted heteroaralkyl; R3 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, optionally substituted aralkenyl or optionally substituted heteroaralkenyl, or R and R3 taken together form a 5 to 7 membered ring; and R4 is optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl or optionally substituted heteroaralkyl, or R3 and R4 taken together with the nitrogen to which R3 and R4 are attached form an optionally substituted 4 to 7 membered heterocyclyi; X1 and X,. are independently selected from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally
substituted heteroaryl, optionally substituted heteroaralkyl or hydroxyalkyl, or X, and Xr taken together form oxo; X2 and X2. are hydrogen, or taken together form oxo; X3 is hydrogen, hydroxy, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl or optionally substituted heteroaralkyl, or X3 and one of X, and Xr taken together form a 4 to 7 membered ring; X4 is hydrogen, optionally substituted alkyl, optionally substituted aralkyl, or hydroxyalkyl; X5 and Xs. are hydrogen or taken together are =NRS;
Rs is hydrogen, R6O2C-, R6O-, cyano, ReCO-, optionally substituted lower alkyl, nitro or Υ’Ύ^Ν-; Y1 and Y2’ are independently hydrogen, alkyl, aralkyl or heteroaralkyi;
Xe and X6. are independently hydrogen, R7R8N-, RgO-, R7R8NCO-, R7R8NSO2-, RgCO-, halo, cyano or nitro;
Rs is hydrogen, optionally substituted lower alkyl or optionally substituted aralkyl or optionally substituted heteroaralkyi; R7 and R8 are independently hydrogen or optionally substituted lower alkyl, or one of R7 and Rs is hydrogen and the other of R7 and Re is R10(O)CCH2- or lower . acyl;
Rg is hydrogen, optionally substituted lower alkyl, lower acyl or R10(O)CCH2-; R10 is hydrogen, optionally substituted lower alkyl, alkoxy or hydroxy; m is 0, 1,2 or 3; n is 1, 2 or 3; or p is 1 or 2, a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.
DETAILED DESCRIPTION OF THE INVENTION
As used above, and throughout the description of the invention, the following terms, unless otherwise indicated, shall be understood to have the following meanings:
Definitions "Patient" includes both human and other mammals. “Alkyl" means an aliphatic hydrocarbon group which may be straight or branched having about 1 to about 20 carbon atoms in the chain. Preferred alkyl groups have 1 to about 12 carbon atoms in the chain. Branched means that one or more lower alkyl groups such as methyl, ethyl or propyl are attached to a linear alkyl chain. “Lower alkyl“ means about 1 to about 4 carbon atoms in the chain which may be straight or branched. The alkyl may be substituted with one or more "alkyl group substituents” which may be the same or different, and include halo, cycloalkyl, alkoxy, amino, acyiamino, aroylamino, carboxy, alkoxycarbonyl, aralkyloxycarbonyl, heteroaralkyloxycarbonyl or Y1'Y2'NCO-, where Y1’ and Y2' are independently hydrogen, alkyl, aralkyl or heteroaralkyl. Exemplary alkyl groups include methyl, trifluoromethyl, cyclopropylmethyl, cyclopentylmethyl, ethyl, n-propyl, Apropyl, n-butyl, f-butyl, π-pentyl, 3-pentyl, methoxyethyl, carboxymethyl, methoxycarbonylethyl, benzyloxycarbonylmethyl, pyridylmethyloxycarbonyimethyl. "Cycloalkyl” means a non-aromatic mono- or multicyclic ring system of about 3 to about 10 carbon atoms. Exemplary monocyclic cycloalkyl rings include cyclopentyl, fluorocyclopentyl, cyclohexyl and cycloheptyl. The cycloalkyl group is optionally partially unsaturated or optionally substituted by one or more halo, methylene (H2C=), alkyl, fused ary or fused heteroaryl.
Exemplary multicyclic cycloalkyl rings include 1-decalin, adamant-(1- or 2-)yl and norbornyl. "Heterocyclyl” means a non-aromatic monocyclic or multicyclic ring system of about 3 to about 10 ring atoms. Preferred rings include aboui 5 to about 6 ring atoms wherein one of the ring atoms is oxygen, nitrogen or sulfur. The heterocyclyl is optionally partially unsaturated or optionally substituted by one or more alkyl, halo, aryl, heteroaryl, fused aryl or fused heteroaryl. Exemplary monocyclic rings include pyrrolidyl, piperidyl, tetrahydrofuranyl, tetrahydrothienyl and tetrahydrothiopyranyl. The thio or nitrogen moiety of the heterocyclyl may also be optionally oxidized to the corresponding N-oxide, S-oxide or S,S-dioxide. "A'ryl" means aromatic carbocyclic radical containing about 6 to about 10 carbon atoms. Exemplary aryl include phenyl or naphthyl, or phenyl substituted or naphthyl substituted with one or more aryl group substituents which may be the same or different, where "aryl group substituent" includes hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroaralkyi, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, acylamino, aroylamino, alkylsuifonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyi, heteroarylsulfinyl, alkylthio, arylthio, heteroarylthio, aralkylthio, heteroaraikylthio, fused cycloalkyl, fused heterocyclyl, arylazo, heteroarylazo, Y1Y2N-, Y1Y2NCO- or Y1Y2NSO2-, where Y1 and Y2 are independently hydrogen, alkyl, aryl, aralkyl or heteroaralkyi, or Y1, Y2 and N taken together form a heterocyclyl. The aryl group substituents are as defined herein. Preferred aryl groups are optionally substituted phenyl or optionally substituted naphthyl. Preferred aryl group substituents include hydrogen, alkyl, hydroxy, acyl, aryl aroyl, aryloxy, halo, nitro, alkoxy, cyano, alkoxycarbonyl, acyiamino, alkylthio, Y1 Y2'N-, Y1 Y2'NCO- or Y1’Y2'NSO2-, where Y1' and Y2' are independently hydrogen, alkyl, aralkyl or heteroaralkyi; preferred phenyl group substituents are aryloxy and aryl; and preferred naphthyl group substituents are nitro, alkoxy and amino. "Heteroaryl” means about a 5- io about a 10- membered aromatic monocyclic or multicyclic hydrocarbon ring system in which one or more of the carbon atoms in the ring system is/are eiement(s) other than carbon, for example nitrogen, oxygen or sulfur. The "heteroaryl" may also be substituted by one or more of the above-mentioned “aryl group substituents”. Exemplary heteroaryl groups include pyrazinyl, furanyl, thienyl, pyridyl, pyrimidinyi, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, pyrrolyl, imidazo[2,1-b]thiazolyl, benzofurazanyl, indolyl, azaindolyl, benzimiddazolyl, benzothienyl, quinolinyl, imidazolyl and isoquinolinyl. Preferred heteroaryl groups in the R substituent include benzothienyl, thienyl, imidazolyl, pyridyl and quinolinyl all of which may be optionally substituted. Where
is monocylic heteroaryl, then preferred heteroaryls include thienyl, pyridyl and furanyl. r “Aralkyl” means an aryl-alkyl- group in which the aryl and alkyl are as previously described. Preferred aralkyls contain a lower alkyl moiety.
Exemplary aralkyl groups include benzyl, 2-phenethyl and naphthalenemethyl. f “Heteroaralkyl” means a heteroaryl-alkyl- group in which theOieteroaryl and alkyl are as previously described. Preferred heteroaralkyls contain a lower alkyl moiety. Exemplary heteroaralkyl groups may contain thienyl, pyridyl, imidazolyl and pyrazinyl. “Aralkenyl” means an aryl-alkenyl- group in which the aryl and alkenyl are as previously described. Preferred aralkenyls contain a lower alkenyl moiety. An exemplary aralkenyl group is 2-phenethenyl. “Heteroaralkenyl”. means a heteroaryl-alkenyl- group in which the heteroaryl and alkenyl are as previously described. Preferred heteroaralkenyls contain a lower alkenyl moiety. Exemplary heteroaralkenyl groups may contain thienyl, pyridyl, imidazolyl and pyrazinyl. “Hydroxyalkyl” means a HO-alkyl- group in which alkyl is as previously defined. Preferred hydroxyalkyls contain lower alkyl. Exemplary hydroxyalkyl groups include hydroxymethyl and 2-hydroxyethyl. "Acyl" means an H-CO- or alkyl-CO- group in which the aikyl group is as previously described. Preferred acyls contain a lower alkyl. Exemplary acyl
groups include formyl, acetyl, propanoyl, 2-methylpropanoyl, butanoyl and palmitoyl. "Aroyl" means an aryl-CO- group in which the alkyl group is as previously described. Exemplary groups include benzoyl and 1- and 2-naphthoyl. "Alkoxy" means an alkyl-O- group in which the alkyl group is as previously described. Exemplary alkoxy groups include methoxy, ethoxy, n-propoxy, /-propoxy, n-butoxy and heptoxy. "Aryloxy" means an aryl-O- group in which the aryl group is as previously described. Exemplary aryloxy groups include phenoxy and naphthoxy. "Aralkyloxy" means an aralkyl-O- group in which the aralkyl groups is as previously described. Exemplary aralkyloxy groups include benzyloxy and 1-or 2-naphthalenemethoxy. t "Alkylthio" means an alkyl-S- group in which the alkyl group is as previously described. Exemplary alkylthio groups include methylthio, ethylthio, /-propylthio and heptylthio. "Arylthio" means an aryl-S- group in which the aryl group is as previously described. Exemplary arylthio groups include phenylthio and naphthylthio. "Aralkylthio" means an aralkyl-S- group in which the aralkyl group is as previously described. An exemplary aralkylthio group is benzylthio. "Y3Y4N-" means a substituted or unsubstituted amino group, wherein Y3 and Y4 are as previously described. Exemplary groups include amino (H2N-), methylamino, ethylmethylamino, dimethylamino and diethylamino. "Alkoxycarbonyl" means an alkyl-O-CO- group. Exemplary alkoxycarbonyl groups include methoxy- and ethoxycarbonyl. "Aryloxycarbonyl" means an aryl-O-CO- group. Exemplary aryloxycarbonyl groups include phenoxy- and naphthoxycarbonyl. "Aralkoxycarbonyl" means an aralkyl-O-CO- group. An exemplary aralkoxycarbonyl group is benzyloxycarbonyl. " Y3Y4NCO-“ means a substituted or unsubstituted carbamoyl group, wherein Y3 and Y4 are as previously described. Exemplary groups are carbamoyl (H2NCO-) and dimethylaminocarbamoyl (Me2NC0-). * Y3Y4NSO2-" means a substituted or unsubstituted sulfamoyl group, wherein Y3 and Y4 are as previously described. Exemplary groups are aminosulfamoyl (H2NSO2-) and dimethylaminosulfamoyl (Me2NSC>2-). "Acyiamino'1 is an acyl-NH- group wherein acyl is as defined herein. “Aroylamino" is an aroyl-NH- group wherein aroyl is as defined herein. "Alkylsulfonyl" means an alkyl-SO2- group. Preferred groups are those in which the alkyl group is lower alkyl. "Alkylsulfinyl" means an alkyl-SO- group. Preferred groups are those in which the alkyl group is lower alkyl. "Arylsulfonyl" means an aryl-SO2- group. "Arylsulfinyl* means an aryl-SO- group. “Halo“ means fluoro, chloro, bromo, or iodo. Preferred are fluoro, chloro or bromo, and more preferred are fluoro or chloro.
Preferred Embodiments A preferred embodiment of the invention is a method for treating a patient suffering from a physiological disorder capable of being modulated by inhibiting an activity of Factor Xa by administering a therapeutically effective amount of a compound of formula I. A preferred compound aspect of the invention is the compound of formula I wherein R3 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted thienyl or optionally substituted benzothienyl.
Another preferred compound aspect of the invention is the compound of formula I wherein n is 1, and m is 1.
Another preferred compound aspect of the invention is the compound of formula I wherein X2 and X? taken together are oxo.
Another preferred compound aspect of the invention is the compound of formula I wherein Xr Xr, X3 and X4 are hydrogen.
Another preferred compound aspect of the invention is the compound of formula I wherein Xg and Xs. taken together are =NH.
Another preferred compound aspect of the invention is the compound of formula I wherein X5 and X5. taken together are =NRS wherein Rs is R6O2C-.
Another preferred compound aspect of the invention is the compound of formula l wherein
is phenyl and the carbon substituted with X5, X5. and HR2N- is attached to the 3-position of the phenyl.
Another preferred compound aspect of the invention is the compound of formula I wherein
is of the formula
Another preferred compound aspect of the invention is.the compound of formula I wherein R is hydrogen, methyl, aralkyl, heteroaralkyl, HO2CCH2-, HOC(O)CH2-, H2NC(O)CH2-, (araIkyl)HNC(O)CH2- or (heteroaralkyl)HNC(O)CH2-.
Another preferred compound aspect of the invention is the compound of formula I wherein X1 is hydrogen and Xr is carboxyalkyl, alkoxycarbonylalkyl or aryl, or X1 and Xr taken together form oxo.
Another preferred compound aspect of the invention is the compound of formula I wherein R1 is R3SO2-..
Another preferred compound aspect of the invention is the compound of formula I wherein R is R3R4NSO2-.
Another preferred compound aspect of the invention is the compound of claim 1 wherein one of X6 and X6. is amino in a para position relative to the € moiety.
Species according to the invention are selected from the group consisting of:
Naphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate;
Dibenzofuran-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-5-oxopyrrolidin-3-yl}amide trifluoroacetate;
Toluene-4-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 3,4-Dihydro-1H-isoquinoline-2-suifonic acid {1-[3-(aminoiminomethyl)benzyI]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate;
3’-Methoxy-biphenyl-4-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate;
Naphthalene-1-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 5-Pyrid-2-ylthiophene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate;.
Biphenyl-4-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzylJ-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 7-Ethoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyI]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 5-Chloro-6-methoxynaphthalene-2-sulfonic acid {1-(3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yI}amide trifluoroacetate; 5-Chloro-6,7-dimethoxynaphthaiene-2-sulfonic acid {1-(3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifiuoroacetate; 7-Aminonaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yI}amide bistrifluoroacetate;
Naphthalene-2-sulfonic acid {1-[4-(aminoiminomethyl)benzyl]-2-oxopyrroIidin-3-(S)-yl}amide trifiuoroacetate; 7-Methoxynaphthalene-2-sulfonic acid [1-(3-aminomethylbenzyi)-2-oxopyrrolidin-3-(S)-yl]amide trifiuoroacetate;
Naphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrroiidin-3-(S)-yl}methyl amide trifiuoroacetate;
Naphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyljpyrrolidin-3-(S)-yljamide bistrifluoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2,5-dioxopyrrolidin-3-(S)-yi}amide trifluoroacetate;
Naphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopiperidin-3-yl}amide trifluoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-azepan-3-(S)-yl}amide trifluoroacetate; 7- Methoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}methyl amide trifluoroacetate; 6-Methoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 6- Methoxynaphthalene-2-sulfonic acid'{1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}methyl amide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-6- methoxynaphthalene-2-sulfonylamino]-N-phenethylacetamide trifluoroacetate; 9,10-Dioxo-8a,9,10,1Oa-tetrahydroanthracene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 8- Chloro-7-methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)-benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifiuoroacetate; 7- Methoxynaphthalene-2-sulfonic acid {1-[4-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifiuoroacetate; 6,7-Dimethoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifiuoroacetate;
Naphtho(2,3-d)-(1,3)dioxole-6-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 7-Benzyloxynaphthalene-2-su!fonic acid {1-[3-(aminoiminomethyl)benzyl]-2· oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 7-Hydroxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 6- Hydroxynaphthalene-2-suifonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 5-Chloro-3-methylbenzo[b]thiophene-2-sulfonic acid {1-[3- (aminoiminomethyl)benzyI]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 5-Chloro-3-methylbenzo[b]thiophene-2-sulfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxopyrroIidin-3-(S)-yl}methyl amide trifluoroacetate; 7- Methylnaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 7-Ethylnaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 5-Chloro-6-aminonaphthalene-2-sulfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide bistrifluoroacetate; 7-Methylaminonaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide bistrifluoroacetate; 2-Methyl-1,2,3,4-tetrahydroisoquinolinyl-7-sulfonic acid {1-[3- (aminoiminomethyl)benzy!]-2-oxopyrrolidin-3-(S)-yl}amide bistrifluoroacetate; 1.2,3,4-Tetrahydroisoquinolinyl-7-sulfonic acid {1-[3- (aminoiminomethyl)benzyi]-2-oxopyrrolidin-3-(S)-yl}methyl amide dihydrochloride; 7-Methoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrroiidin-3-(S)-yl}-(4-nitrobenzyl)amide trifiuoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-(4-aminobenzyl)amide bistrifluoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}(3-nitrobenzyl)amide trifiuoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(arninoiminomethyI)benzyl]-2-oxopyrrolidin-3-(S)-yl}(3-aminobenzyl)amide bistrifluoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-(2-nitrobenzyl)amide trifiuoroacetate; 3-[2-Oxo-3(S)-(2-phenylethenesulfonylamino)pyrrolidin-1-ylmethyl]-benzamidine trifiuoroacetate; 3-[2-Oxo-3(S)-(2-phenylethanesulfonylamino)pyrrolidin-1-ylmethyl]-benzamidine trifiuoroacetate; [lmino-(3-{3-[7-Methoxynaphthalene-2-sulfonyl)methylamino]-2-oxo-3(S)-pyrrolidin-1-ylmethyl]phenyl)methyl]carbamic acid ethyl ester; 3-[2-Oxo-3(S)-{2-(pyridin-4-ylamino)-ethanesulfonylamino}-pyrrolidin-1-ylmethylj-benzamidine bistrifluoroacetate; 2’-Methoxybiphenyl-4-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl} amide trifiuoroacetate; 5,6,7,8-Tetrahydrophenanthrene-3-sutfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}amide trifiuoroacetate; lsoquinolinyl-5-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}amide bistrifluoroacetate; 5-Chlorothiophene-2-sulfonic acid {1 -[3-(arninoirninomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}amide trifiuoroacetate; 2,4-Diaminoquinazoline-6-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}amide trifiuoroacetate; 7-Methoxy-2-naphthalenesulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}ethyiamide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1 -[3-(aminoiminomethyi)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(3-fluorobenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(4-methylbenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(3-methylbenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyi)benzyi]-2-oxo-3(S)-pyrrolidin-3-yl}napthalene-2-ylmethylamide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrroiidin-3-yl}(3-phenylallyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(3-methylbenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(2-fluorobenzyl)amide trifiuoroacetate; 2- Fluorobiphenyl-4-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}methylamide trifiuoroacetate; 3- [{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-3-yl}-(7- methoxynaphthalene-2-sulfonyl)amino]propionamide trifiuoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}naphthalene-2-sulfonylamino]-N-phenethylacetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}biphenyl-4-sulfonylamino]-N-phenethylacetamide trifluoroacetate; 2-[{1-I3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N-phenethylacetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyi)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N-ethylacetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N,N-dimethylacetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-suifonylaminoJ-N-benzylacetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonyiamino]-N-(2-p-toluylethyl)acetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N-(3-phenylpropyl)acetamide trifluoroacetate; 2-[{1-l3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthaiene-2-sulfonyiamino]-N-(4-methylbenzyl)acetamide trifluoroacetate; 2-r(1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthaiene-2-sulfonyiamino]-N-[2-(3-fluorophenyl)ethyl]acetamide trifluoroacetate; 2-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrroiidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N-indan-2-ylacetamide trifluoroacetate; 2- [{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-7- methoxynaphthalene-2-sulfonylamino]-N-(2-pyridin-3-yl-ethyl)acetamide bistrifluoroacetate; 4.5- Dichlorothiophene-2-sulfonic acid {1 -[3-(aminoiminomethyl)benzyi]-2-oxo-3(S)-pyrrolidin-3-yl}amide trifiuoroacetate 4.5- Dichlorothiophene -2-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrroiidin-3-yl}-methyiamide trifiuoroacetate; 4.5- Dichlorothiophene-2-sulfonic acid {1-[3-(aminoiminomethyl)benzyI]-2-oxo-3(S)-pyrrolidin-3-yl}benzylamide trifiuoroacetate; 7-Methoxy-2-napthalenesuIfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-2-cyclopropylphenethylamide trifiuoroacetate; 3’-Methyl-biphenyl-4-sulfonic acid {1-[3-(aminoiminomethyi)benzyl]-2-oxopyrrolidin-3(S)-yl} amide trifiuoroacetate; 3- [{1-[3-(Aminoiminomethyi)benzyl]-2-oxopyrrolidin-3(S)-3-yl}-(7- methoxynaphthalene-2-sulfonyl)amino]acetamide trifiuoroacetate; 3-[{1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-3-yl}-(7- methoxynaphthalene-2-sulfonyl)amino]-2-methylacetamide trifiuoroacetate; 7-Methoxynaphthalene-2-suifonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxo-azetidin-3(S)-yl}amide trifiuoroacetate; 7-Methoxynaphthalene-2-sulfonic acid {1-[3-(aminoiminorriethyl)benzyl]-2-oxo-azetidin-3(S)-yl}benzylamide trifiuoroacetate; 5,6,7,8-Tetrahydronaphthaiene-2-sulfonic acid {1-[3-(aminoiminomethyi)-benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-(2-methoxybenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {l-[3-(aminoiminomethyi)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-(3-methoxybenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesuifonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yI}-(4-methoxybenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyI)benzyl]-2-oxo-3(S)-pyrroiidin-3-yl}(pyridin-2-ylmethyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(pyridin-3-ylmethyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyI)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(pyridin-4-ylmethyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-(1 -benzyl-1 H-imidazol-2-ylmethyl)amide trifiuoroacetate; (1-Methyl-1H-imidazol-2-yl)benzene-4-sulfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-(3-hydroxybenzyl)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}-(2-hydroxybenzyI)amide trifiuoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(pyrazol-3-ylmethyl)amide trifiuoroacetate;
Quinoline-6-sulfonic acid {1 -[S-famino'minomethyObenzylJ^-oxopyrrolidin-S-(S)-yl}amide trifiuoroacetate; 4-Pyridin-4-ylbenzene sulfonic acid {1-[3-(aminoiminomethy!)benzyl]-2-oxopyrrolidin-3(S)-yl}amide bistrifluoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyI]-2-oxo-3(S)-pyrroiidin-3-yl}(thiophene-2-ylmethyl)amide trifluoroacetate; 4-Pyridin-3-ylbenzene sulfonic acid {1-[3-(aminoiminqmethyi)benzyl]-2-oxopyrrolidin-3(S)-yl}amide bistrifluoroacetate; N-Methylpyrid-4-ylphenyl-4-sulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifluoroacetate; 2-Methoxyquinoline-7-sulfonic acid {1 -[3-(aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide trifluoroacetate; 4-(6-Methoxypyridin-2-yl)benzene-4-sulfonic acid {1-[3- (aminoiminomethyl)benzyi]-2-oxopyrrolidin-3(S)-yl}amide bistrifluoroacetate; 4-(3-Chloropyridin-2-yloxy)benzene-4-sulfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifluoroacetate; 4-(N-Oxidopyridin-3-yl)benzene-4-sulfonic acid {1-[3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifluoroacetate; 4-Phenoxybenzene-4-suifonic acid {1-[3-(aminoiminomethyl)benzyI]-2-oxopyrrolidin-3(S)-yl} amide trifluoroacetate; 7-Methoxy-2-napthalenesulfonic acid {1-[3-(aminoiminomethyl)benzyl]-2-oxo-3(S)-pyrrolidin-3-yl}(thiophen-3-ylmethyl)amide trifluoroacetate; 6-Methoxynaphthalene-2-sulfonic acid {1 -[3-(methoxyaminoiminomethyl)-benzyl]-2-oxopyrrolidin-3-(S)-yl}methylamide trifluoroacetate; 6-Methoxynaphthalene-2-sulfonic acid {1-[3-(cyanoaminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}methyiamide trifluoroacetate; 6-Methoxynaphthaiene-2-sulfonic acid {1-[3-(hydroxyaminoiminomethyl)-benzyl]-2-oxopyrrolidin-3-(S)-yl}-methylamide trifluoroacetate; 4-Amino-3-[3-(S)-(7-methoxynaphthalene-2-sulfonyiamino)-2-oxopyrrolidin-1-yl-methyt]benzamidine dihydrochloride; 4-Amino-3-[3-(S)-(7-methoxynaphthalene-2-sulfonylrnethylamino)-2-oxopyrrolidin-1-yl-methyl]benzamidine trifiuoroacetate; N-(4-Carbamimidoyl-2-{3-[(7-methoxynaphthalene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-(S)-ylmethyl}phenyl)acetamide trifluroacetate; 4-Amino-3-[3-(S)-(4-tert-butylbenzenesulfonylamino)-2-oxopyrrolidin-1-yl- ' methyl]benzamidine trifiuoroacetate; 3- Amino-5-[3-(S)-(7-methoxynaphthalene-2-sulfonylamino)-2-oxopyrrolidin-1-yl-methyl]benzamidine bistrifluoroacetate; {4-(Aminoiminomethyl)-2-[3-(7-methoxynaphthalene-2-sulfonylamino)-2-oxopyrrolldin-1-ylmethyl]phenoxy}acetic acid methyl ester trifiuoroacetate; {4-(Aminoiminomethyl)-2-[3-(7-methoxynaphthalene-2-suifonylamino)-2-oxopyrrolidin-1-ylmethyl]phenoxy}acetic acid trifiuoroacetate; 2-Chloro-6-nitrophenoxybenzene sulfonic acid {1 -[3- (aminoiminomethyl)benzyl]-2-oxopyrrolidin-3(S)-yl}amide trifiuoroacetate; 4- [3-(S)-(7-Methoxynaphthaiene-2-sulfonylamino)-2-oxopyrrolidin-1-ylmethyl]-thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl](7-methoxynaphthalene-2-sulfonyl)amino]acetamide trifiuoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)benzylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 4- [3-(S)-(5-Chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyi]thiophene-2-carboxamidine trifiuoroacetate; 5- {3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)methylarnino]-2-oxopyrroIidin-1-ylmethyl}thiophene-3-carboxamidine trifiuoroacetate; 4-{3-(S)-[( 5-Chloro-3-methyibenzo[b]thiophene-2-sulfonyl)benzylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[(Methanesulfonyl)-(3-phenylpropyl)amino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[(Methanesulfonyl)(naphthalene-2-yl)amino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[(4,5-Dichlorothiophene-2-sulfonyl)benzylaminoJ-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[( 5-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthalene-2-sulfonyl)amino]-N-phenethylacetamide trifiuoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(4,5-dichlorothiophene-2-sulfonyl)amino]-N-benzylacetamide trifiuoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthalene-2-suIfonyl)amino]-N-benzylacetamide trifiuoroacetate; 2-[[1-(4-Carbamimidoylthiophene-2-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthalene-2-sulfonyl)amino]acetamide trifiuoroacetate; 2-[[1-(4-Carbamimidoylthiophene-2-yimethyl)-2-oxopyrrolidin-3-(S)-y!l·-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl)amino]acetic acid methyl ester; 4-{3-(S)-[(7-Aminonaphthalene-2-sulfonyl)benzylamino]-2-oxopy'rolidin-1-ylmethyl}thiophene-2-carboxamidine bistrifluoroacetate; 4-{3-(S)-[(7-Aminonaphthalene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine bistrifluoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yi]-(7-aminonaphthalene-2-sulfonyl)amino]acetamide bistrifluoroacetate; 4-[3-(S)-( 6-Amino-5-chloro-2-sulfonylamino)-2-oxopyrrolidin-1-ylmethyl]-thiophene-2-carboxamidine trifiuoroacetate; 4-{3-(S)-[(6-Amino-5-chloro-naphthalene-2-sulfonyI)methylamino]-2-oxopyrroiidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 2-[[1-(5-Carbamimidoylthiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(6-amino-5-chloronaphthalene-2-sulfonyl)amino]acetamide trifiuoroacetate; 4- [3-(S)-(6-Aminonaphthalene-2-sulfonylamino)-2-oxopyrrolidin-1-yimethyl]-thiophene-2-carboxamidine dihydrochloride; 5- [3-(S)-(7-Methoxynaphthalene-2-sulfonylamino)-2-oxopyrroiidin-1-ylmethyI]-thiophene-2-carboxamidine trifiuoroacetate; 5-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; 5-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)benzylamino]-2-oxopyrrolidin-l-ylmethyl}thiophene-2-carboxamidine trifiuoroacetate; IAmino-(4-{3-(S)-(7-methoxynaphthalene-2-sulfony!)methylamino]-2-oxopyrrolidin-1-ylmethyl}thiophene-2-yl)methylene]carbamic acid methyl e~ter trifiuoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-yimethyl}thiophene-2-N-hydroxycarboxamidine trifiuoroacetate; 4-[3-(S)-(7-Methoxynaphthalene-2-sulfonylamino)-2-oxopyrrolidin-1-ylmethyl]-pyridine-2-carboxamidine trifluoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)benzylamino]-2-oxopyrroiidin-1-ylmethyl}pyridine-2-carboxamidine trifluoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)methyiamino]-2-oxopyrroIidin-1-yimethyl}pyridine-2-carboxamidine trifluoroacetate; 4-[3-(S)-(5-Chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-2-oxopyrrolidin-1-ylmethyl]pyridine-2-carboxamidine trifluoroacetate; 4-{3-(S)-[(5-Chloro-3-methyIbenzo[b]thiophene-2-sulfonyl)methylamino]-2-oxopyrrolidin-1-ylmethyI}pyridine-2-carboxamidine trifluoroacetate; 2-{[1-(2-Carbamimidoylpyridine-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthaiene-2-sulfonyl)amino}acetamide trifluoroacetate; 2-{[1-(2-Carbamimidoyl-pyridine-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7- methoxynaphthalene-2-sulfonyl)amino}-N-phenethylacetamide trifluoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)-thiophen-3-ylmethylamino]-2-oxopyrrolidin-1-ylmethyl}pyridine-2-carboxamidine trifluoroacetate; 4-{3-(S)-[(7-Methoxynaphthalene-2-sulfonyl)thiophen-3-ylmethylamino]-2-oxopyrrolidin-1 -ylmethyl}thiophene-2-carboxamidine trifluoroacetate; 4- {3-(S)-[(4-(6-Nitro-2-chlorophenoxy)benzenesulfonyl)amino]-2-oxopyrrolidin-1 -ylmethyl}thiophene-2-carboxamidine trifluoroacetate; 5- {3-(S)-[(7-Methoxynaphthalene-2-sulfonyIamino}-2-oxopyrrolidin-1-ylmethyI}-furan-2-carboxamidine trifluoroacetate; and 4-[3-(S)-(5-Chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)-2-oxopyrrolidin-1-yimethyl]furan-2-carboxamidine trifluoroacetate.

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  1. Original document published without claims.
APAP/P/1997/001144A 1995-06-07 1996-06-07 Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl) phenylalkyl]-azaheterocyclylamide compounds. AP799A (en)

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