AP452A - "Diborane reduction of certain aryl piperidines". - Google Patents

"Diborane reduction of certain aryl piperidines". Download PDF

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Publication number
AP452A
AP452A APAP/P/1994/000624A AP9400624A AP452A AP 452 A AP452 A AP 452A AP 9400624 A AP9400624 A AP 9400624A AP 452 A AP452 A AP 452A
Authority
AP
ARIPO
Prior art keywords
formula
compound
process according
diborane
solution
Prior art date
Application number
APAP/P/1994/000624A
Other languages
English (en)
Other versions
AP9400624A0 (en
Inventor
Sidney Edward Callander
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AP9400624A0 publication Critical patent/AP9400624A0/xx
Application granted granted Critical
Publication of AP452A publication Critical patent/AP452A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1994/000624A 1993-03-13 1994-03-10 "Diborane reduction of certain aryl piperidines". AP452A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939305175A GB9305175D0 (en) 1993-03-13 1993-03-13 Novel process
PCT/EP1994/000694 WO1994021609A1 (en) 1993-03-13 1994-03-08 Process for preparing acryl-piperidine carbinols

Publications (2)

Publication Number Publication Date
AP9400624A0 AP9400624A0 (en) 1994-04-30
AP452A true AP452A (en) 1996-01-19

Family

ID=10731995

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1994/000624A AP452A (en) 1993-03-13 1994-03-10 "Diborane reduction of certain aryl piperidines".

Country Status (27)

Country Link
US (1) US5681962A (de)
EP (1) EP0688317B1 (de)
JP (1) JPH08507540A (de)
KR (1) KR100296719B1 (de)
CN (2) CN1041918C (de)
AP (1) AP452A (de)
AT (1) ATE207898T1 (de)
AU (1) AU682497B2 (de)
BR (1) BR9406035A (de)
CA (1) CA2158175A1 (de)
CZ (1) CZ235595A3 (de)
DE (1) DE69428886T2 (de)
DZ (1) DZ1758A1 (de)
ES (1) ES2164700T3 (de)
FI (1) FI954272A7 (de)
GB (1) GB9305175D0 (de)
HU (1) HUT72087A (de)
IL (1) IL108946A (de)
MA (1) MA23134A1 (de)
NO (1) NO306717B1 (de)
NZ (1) NZ262735A (de)
PH (1) PH31434A (de)
PL (1) PL176907B1 (de)
RU (1) RU2141477C1 (de)
SK (1) SK281977B6 (de)
WO (1) WO1994021609A1 (de)
ZA (1) ZA941716B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP1384711A1 (de) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optische Trennung eines Piperidin-Derivates
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
PL337513A1 (en) * 1997-05-29 2000-08-28 Smithkline Beecham Corp Novel method of obtaining pharmaceutically active compounds and their associated intermediate products
ES2149687B1 (es) * 1998-04-08 2001-05-16 Medichem Sa Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.
GB0003232D0 (en) * 2000-02-11 2000-04-05 Smithkline Beecham Plc Novel composition
ES2325353T3 (es) * 2000-08-11 2009-09-02 Ono Pharmaceutical Co., Ltd. Derivados de piperidina y medicamentos a base de tales ingredientes activos.
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
WO2003024918A1 (es) * 2001-09-14 2003-03-27 Medichem S.A. Compuestos intermedios para la preparación de mirtazapina y sus procedimientos de obtención
JP5165951B2 (ja) * 2006-07-24 2013-03-21 住友化学株式会社 （±）−トランス−４−（４−フルオロフェニル）−３−ヒドロキシメチルピペリジンの製造方法
WO2008013248A1 (en) * 2006-07-24 2008-01-31 Sumitomo Chemical Company, Limited Process for production of (±)-trans-4-(4- fluorophenyl)-3-hydroxymethylpiperidine
CN109020872B (zh) * 2018-06-26 2020-05-12 浙江邦富生物科技有限责任公司 一种盐酸帕罗西汀关键中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007196A (en) * 1973-01-30 1977-02-08 A/S Ferrosan 4-Phenylpiperidine compounds
EP0374675A2 (de) * 1988-12-22 1990-06-27 Novo Nordisk A/S Reduktion von Piperidindion-Derivaten und Zwischenprodukte

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5470262A (en) * 1977-11-09 1979-06-05 Daiichi Kagaku Yakuhin Kk Manufacture of pyrrolidinee22methanol
FR2581242B1 (fr) * 1985-04-24 1988-08-26 Telemecanique Electrique Dispositif de commande electrique adaptable a un dispositif de commutation a deux etats
DE3680184D1 (de) * 1985-08-10 1991-08-14 Beecham Group Plc Verfahren zur herstellung von arylpiperidincarbinol.
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007196A (en) * 1973-01-30 1977-02-08 A/S Ferrosan 4-Phenylpiperidine compounds
EP0374675A2 (de) * 1988-12-22 1990-06-27 Novo Nordisk A/S Reduktion von Piperidindion-Derivaten und Zwischenprodukte

Also Published As

Publication number Publication date
FI954272L (fi) 1995-09-12
ZA941716B (en) 1995-01-13
CN1041918C (zh) 1999-02-03
CN1055470C (zh) 2000-08-16
BR9406035A (pt) 1996-01-02
CN1203226A (zh) 1998-12-30
JPH08507540A (ja) 1996-08-13
HUT72087A (en) 1996-03-28
CA2158175A1 (en) 1994-09-29
DE69428886T2 (de) 2002-04-25
AU6258794A (en) 1994-10-11
SK281977B6 (sk) 2001-09-11
EP0688317A1 (de) 1995-12-27
CZ235595A3 (en) 1996-01-17
US5681962A (en) 1997-10-28
WO1994021609A1 (en) 1994-09-29
ATE207898T1 (de) 2001-11-15
NO953598D0 (no) 1995-09-12
PH31434A (en) 1998-11-03
EP0688317B1 (de) 2001-10-31
FI954272A0 (fi) 1995-09-12
AU682497B2 (en) 1997-10-09
DZ1758A1 (fr) 2002-02-17
ES2164700T3 (es) 2002-03-01
RU2141477C1 (ru) 1999-11-20
AP9400624A0 (en) 1994-04-30
NZ262735A (en) 1996-10-28
KR100296719B1 (ko) 2001-10-24
FI954272A7 (fi) 1995-09-12
NO953598L (no) 1995-09-12
NO306717B1 (no) 1999-12-13
GB9305175D0 (en) 1993-04-28
PL176907B1 (pl) 1999-08-31
IL108946A0 (en) 1994-06-24
PL310469A1 (en) 1995-12-11
MA23134A1 (fr) 1994-10-01
IL108946A (en) 1997-11-20
DE69428886D1 (de) 2001-12-06
SK114095A3 (en) 1996-01-10
CN1119012A (zh) 1996-03-20

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