AP2860A - Carbazole compounds and therapeutic uses of the compounds - Google Patents

Carbazole compounds and therapeutic uses of the compounds

Info

Publication number
AP2860A
AP2860A AP2011005637A AP2011005637A AP2860A AP 2860 A AP2860 A AP 2860A AP 2011005637 A AP2011005637 A AP 2011005637A AP 2011005637 A AP2011005637 A AP 2011005637A AP 2860 A AP2860 A AP 2860A
Authority
AP
ARIPO
Prior art keywords
compounds
therapeutic uses
carbazole
carbazole compounds
therapeutic
Prior art date
Application number
AP2011005637A
Other languages
English (en)
Other versions
AP2011005637A0 (en
Inventor
John Tucker
Sergy Sviridov
Leonid Brodsky
Original Assignee
Incuron Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incuron Llc filed Critical Incuron Llc
Publication of AP2011005637A0 publication Critical patent/AP2011005637A0/xx
Application granted granted Critical
Publication of AP2860A publication Critical patent/AP2860A/xx

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Classifications

    • AHUMAN NECESSITIES
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    • A47CCHAIRS; SOFAS; BEDS
    • A47C4/00Foldable, collapsible or dismountable chairs
    • A47C4/02Dismountable chairs
    • A47C4/028Upholstered chairs, e.g. metal, plastic or wooden chairs
    • AHUMAN NECESSITIES
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    • A47C13/00Convertible chairs, stools or benches
    • A47C13/005Modular seating
    • AHUMAN NECESSITIES
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    • A47CCHAIRS; SOFAS; BEDS
    • A47C15/00Other seating furniture
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    • AHUMAN NECESSITIES
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    • A47C17/04Seating furniture, e.g. sofas, couches, settees, or the like, with movable parts changeable to beds; Chair beds
    • A47C17/045Seating furniture having loose or by fabric hinge connected cushions changeable to beds
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    • A47CCHAIRS; SOFAS; BEDS
    • A47C31/00Details or accessories for chairs, beds, or the like, not provided for in other groups of this subclass, e.g. upholstery fasteners, mattress protectors, stretching devices for mattress nets
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
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    • A61K9/0012Galenical forms characterised by the site of application
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
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    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B1/00Devices for securing together, or preventing relative movement between, constructional elements or machine parts
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B12/00Jointing of furniture or the like, e.g. hidden from exterior
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
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    • F16B2200/81Use of a material of the hooks-and-loops type
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B2200/00Constructional details of connections not covered for in other groups of this subclass
    • F16B2200/83Use of a magnetic material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T29/00Metal working
    • Y10T29/49Method of mechanical manufacture
    • Y10T29/49826Assembling or joining
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Nursing (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AP2011005637A 2008-10-06 2009-10-05 Carbazole compounds and therapeutic uses of the compounds AP2860A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10291308P 2008-10-06 2008-10-06
PCT/US2009/059558 WO2010042445A1 (fr) 2008-10-06 2009-10-05 Composés carbazole et utilisations thérapeutiques desdits composés

Publications (2)

Publication Number Publication Date
AP2011005637A0 AP2011005637A0 (en) 2011-04-30
AP2860A true AP2860A (en) 2014-02-28

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Application Number Title Priority Date Filing Date
AP2011005637A AP2860A (en) 2008-10-06 2009-10-05 Carbazole compounds and therapeutic uses of the compounds

Country Status (27)

Country Link
US (5) US8765738B2 (fr)
EP (1) EP2356093B1 (fr)
JP (1) JP5694172B2 (fr)
KR (1) KR101586112B1 (fr)
CN (1) CN102203063B (fr)
AP (1) AP2860A (fr)
AU (1) AU2009302546B2 (fr)
BR (1) BRPI0920876A2 (fr)
CA (1) CA2736097C (fr)
CU (1) CU24087B1 (fr)
CY (1) CY1113924T1 (fr)
DK (1) DK2356093T3 (fr)
ES (1) ES2402395T3 (fr)
GE (1) GEP20146131B (fr)
HR (1) HRP20130313T1 (fr)
IL (1) IL211430A0 (fr)
MX (1) MX2011003416A (fr)
NZ (1) NZ591516A (fr)
PL (1) PL2356093T3 (fr)
PT (1) PT2356093E (fr)
RS (1) RS52702B (fr)
RU (1) RU2497807C2 (fr)
SI (1) SI2356093T1 (fr)
SM (1) SMT201300042B (fr)
UA (1) UA107652C2 (fr)
WO (1) WO2010042445A1 (fr)
ZA (1) ZA201101513B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107652C2 (en) * 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds
JP5831068B2 (ja) * 2011-09-13 2015-12-09 コニカミノルタ株式会社 縮合複素環化合物の製造方法
PT2802320T (pt) * 2011-11-15 2019-06-17 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Compostos tricíclicos, composições que os compreendem e usos destas
CN104302286A (zh) * 2012-03-27 2015-01-21 英丘伦有限责任公司 用于治疗乳腺癌的curaxin和用于鉴别可能响应的患者的方法
CN104203915B (zh) 2012-04-25 2017-03-08 霍夫曼-拉罗奇有限公司 (3,4‑二氯‑苯基)‑((s)‑3‑丙基‑吡咯烷‑3‑基)‑甲酮盐酸盐和制造方法
EP2855458B1 (fr) 2012-05-11 2018-08-08 Reset Therapeutics, Inc. Sulfonamides contenant du carbazole en tant que modulateurs de cryptochrome
WO2014124454A1 (fr) 2013-02-11 2014-08-14 Katerina Gurova Utilisation du complexe 'facilite la transcription de la chromatine'(fact) en cancérologie
WO2014207688A1 (fr) * 2013-06-26 2014-12-31 Universidade Do Porto Oxazoloisoindolinones dérivées de tryptophanol : des activateurs de p53 à petites molécules
WO2015020553A1 (fr) * 2013-08-07 2015-02-12 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Composés carbazole et leurs méthodes d'utilisation
WO2015020556A1 (fr) * 2013-08-08 2015-02-12 Общество С Ограниченной Ответственностью "Панацела Лабс" Composé de xénomycine ayant des propriétés antifongiques
WO2015050471A1 (fr) * 2013-10-02 2015-04-09 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Composés carbazole et leurs méthodes d'utilisation
WO2015050472A1 (fr) * 2013-10-02 2015-04-09 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Composés indole fusionnés et leurs méthodes d'utilisation
US20160303078A1 (en) * 2013-12-10 2016-10-20 Incuron, Llc Methods of modulating various biomarkers with curaxins
CN106572992A (zh) * 2014-04-06 2017-04-19 英丘伦有限责任公司 用curaxins进行组合治疗
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
CN103936654B (zh) * 2014-04-08 2016-05-18 南京林业大学 一类脱氢枞酸吲哚衍生物的用途
CA2953843C (fr) * 2014-07-04 2023-03-14 Merck Patent Gmbh Derives d'azepanyle et compositions pharmaceutiques a activite anti-parasitaire les contenant
US10632102B2 (en) 2015-06-15 2020-04-28 Raziel Therapeutics Ltd Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof
CN105272903B (zh) * 2015-11-17 2018-07-10 江苏师范大学 系列含氟咔唑类化合物及其制备方法和应用
CN109593057B (zh) * 2017-09-30 2022-03-04 成都中创蜀洋生物科技有限公司 氘代咔唑类化合物
CN109528712B (zh) * 2019-01-24 2020-11-17 江南大学 9-甲基-3,6-二乙酰基咔唑用于治疗或预防肿瘤疾病的用途
CN115066241A (zh) * 2019-09-15 2022-09-16 拉结尔治疗有限公司 用于治疗实体瘤的组合物
WO2023220558A1 (fr) * 2022-05-09 2023-11-16 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Combinaison de curaxines et d'inhibiteurs de point de contrôle immunitaire pour le traitement du cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2715680A1 (de) * 1977-04-07 1978-10-12 Henkel Kgaa Haarfaerbemittel
AU2003272175A1 (en) * 2002-10-21 2004-05-04 Aprea Ab Reactivation of wild type p53 in human tumour cells by a low molecular weight compound
EP1462105A1 (fr) * 2003-03-28 2004-09-29 Procorde GmbH Inhibiteurs spécifiques de l'activation de NF-kB et méthode de traitement des processus inflammatoires des maladies cardiovasculaires
US7169802B2 (en) * 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
AU2005267117C1 (en) * 2004-07-20 2012-10-25 Cleveland Clinic Foundation Inhibition of NF-KB
JP2009001495A (ja) * 2005-10-13 2009-01-08 Taisho Pharmaceutical Co Ltd 2−アリール−ベンゾイミダゾール−5−カルボキサミド誘導体
AU2006316322B2 (en) * 2005-11-22 2011-08-25 Merck Canada Inc. Tricyclic compounds useful as inhibitors of kinases
US20100047783A1 (en) * 2006-06-20 2010-02-25 El-Diery Wafik S Small molecule modulators of p53 family signaling
RU2315594C1 (ru) * 2006-09-01 2008-01-27 Всеволод Иванович Киселев Антиэстрогенное и антипролиферативное средство для лечения и профилактики заболеваний женской репродуктивной системы
UA107652C2 (en) * 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds
CN104302286A (zh) * 2012-03-27 2015-01-21 英丘伦有限责任公司 用于治疗乳腺癌的curaxin和用于鉴别可能响应的患者的方法

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