AP2570A - Solubilization and targeted delivery of drugs withself-assembling amphiphilic polymers - Google Patents

Solubilization and targeted delivery of drugs withself-assembling amphiphilic polymers

Info

Publication number
AP2570A
AP2570A AP2008004573A AP2008004573A AP2570A AP 2570 A AP2570 A AP 2570A AP 2008004573 A AP2008004573 A AP 2008004573A AP 2008004573 A AP2008004573 A AP 2008004573A AP 2570 A AP2570 A AP 2570A
Authority
AP
ARIPO
Prior art keywords
withself
solubilization
drugs
targeted delivery
amphiphilic polymers
Prior art date
Application number
AP2008004573A
Other languages
English (en)
Other versions
AP2008004573A0 (en
Inventor
Anil Diwan
Ann Louise Onton
Jayant G Tatake
Original Assignee
Allexcell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allexcell Inc filed Critical Allexcell Inc
Publication of AP2008004573A0 publication Critical patent/AP2008004573A0/xx
Application granted granted Critical
Publication of AP2570A publication Critical patent/AP2570A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
    • C08G75/02—Polythioethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AP2008004573A 2006-01-19 2006-01-19 Solubilization and targeted delivery of drugs withself-assembling amphiphilic polymers AP2570A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/001820 WO2007084126A1 (en) 2006-01-19 2006-01-19 Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers

Publications (2)

Publication Number Publication Date
AP2008004573A0 AP2008004573A0 (en) 2008-08-31
AP2570A true AP2570A (en) 2013-01-23

Family

ID=38287941

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004573A AP2570A (en) 2006-01-19 2006-01-19 Solubilization and targeted delivery of drugs withself-assembling amphiphilic polymers

Country Status (20)

Country Link
US (1) US8173764B2 (ko)
EP (1) EP1979407B1 (ko)
JP (1) JP5027157B2 (ko)
KR (1) KR101263057B1 (ko)
CN (1) CN101400730B (ko)
AP (1) AP2570A (ko)
AU (1) AU2006336311B2 (ko)
BR (1) BRPI0621291A2 (ko)
CA (1) CA2637560C (ko)
CY (1) CY1115715T1 (ko)
DK (1) DK1979407T5 (ko)
EA (1) EA025295B1 (ko)
ES (1) ES2523431T3 (ko)
IL (2) IL192869A (ko)
NO (1) NO338835B1 (ko)
NZ (1) NZ570484A (ko)
PL (1) PL1979407T3 (ko)
PT (1) PT1979407E (ko)
SI (1) SI1979407T1 (ko)
WO (1) WO2007084126A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897170B2 (en) * 2006-08-25 2011-03-01 Boston Scientific Scimed, Inc. Medical devices having improved mechanical performance
US20100008938A1 (en) * 2007-01-22 2010-01-14 Anil Diwan Self assembling amphiphilic polymers as antiviral agents
JP5296787B2 (ja) * 2007-07-19 2013-09-25 オールエクセル，インコーポレイティド 抗癌剤としての自己集合性の両親媒性ポリマー
US9579400B2 (en) 2008-09-23 2017-02-28 The Regents Of The University Of California Nanocarriers for drug delivery
EP2336218B1 (en) * 2008-09-30 2017-02-22 Osaka University Hydrophilic material, medical material and sustained release pharmaceutical material
KR100987693B1 (ko) 2008-10-20 2010-10-13 서울대학교산학협력단 폴리(에틸렌 글리콜)-ｂ-[폴리(Ｌ-세린)-ｇ-폴리(Ｄ,Ｌ-락티드)]의 블록공중합체 및 이를 이용한 약물전달체용 나노입자의 제조 방법
MX2013005275A (es) 2010-11-10 2014-03-31 Battelle Memorial Institute Sistema de liberacion de particulas de polimero auto-ensamble.
US8496946B2 (en) 2011-03-10 2013-07-30 International Business Machines Corporation Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom
US9642916B2 (en) 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
CN103254442B (zh) * 2013-04-28 2015-01-14 天津大学 二硫键键接的聚酯梳型接枝共聚物及其制备方法和应用
US10780175B2 (en) 2015-04-18 2020-09-22 The Texas A&M University System Polymer systems and their applications in diagnostics and drug delivery
WO2017193294A1 (zh) * 2016-05-10 2017-11-16 苏州大学张家港工业技术研究院 基于聚氨基酸的功能性生物可降解纳米粒子的制备方法
WO2018053316A1 (en) 2016-09-15 2018-03-22 The Regents Of The University Of California Improved hybrid telodendrimers
WO2018144481A1 (en) 2017-01-31 2018-08-09 The Regents Of The University Of California Multi-arm block-copolymers for multifunctional self-assembled systems
CN110423355B (zh) * 2019-08-29 2021-09-14 武汉轻工大学 羧甲基化莲藕多糖-曲古霉素a轭合物的制备方法
CN113082219B (zh) * 2021-04-07 2023-02-17 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种基于π-π作用的疏水药物的增溶方法
WO2022271183A1 (en) * 2021-06-25 2022-12-29 Allexcel Inc. Self-assembling amphphlic polymers as anti-covid-19 agents
CN120981506A (zh) * 2023-03-30 2025-11-18 柏林自由大学 异多价聚合物及其抗病毒应用
CN120938965A (zh) * 2025-10-10 2025-11-14 浙江大学医学院附属第一医院(浙江省第一医院) 纳米金担载ns9283靶向长效镇痛药物及制备方法

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US5919442A (en) * 1995-08-11 1999-07-06 Dendritech, Inc. Hyper comb-branched polymer conjugates
US20030072734A1 (en) * 1999-09-04 2003-04-17 Beiersdorf Ag Sulphonated comb polymers having a selected lithium/sodium ratio and preparations, in particular hair cosmetic preparations, based on such sulphonated comb polymers

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US5319006A (en) * 1992-11-23 1994-06-07 Arco Chemical Technology, L.P. Preparation of polyesters from polyethers by an ester-insertion process
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
DE19726186A1 (de) 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
US6150459A (en) 1998-04-13 2000-11-21 Massachusetts Institute Of Technology Comb polymers for regulating cell surface interactions
US6162877A (en) * 1998-12-04 2000-12-19 Hercules Incorporated Hydrophobically modified comb copolymers
EP1063254A1 (de) * 1999-06-25 2000-12-27 Technische Uni München, Klinikum rechts der Isar, Inst. für Experiment. Onkoligie und Therapieforschung Copolymere für den Transport von Nukleinsäuren in die Zelle
US6521736B2 (en) * 2000-09-15 2003-02-18 University Of Massachusetts Amphiphilic polymeric materials
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
WO2003059321A1 (en) 2001-12-21 2003-07-24 Soane David S Use of oligomers and polymers for drug solublization, stabilization, and delivery
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
GB0221942D0 (en) 2002-09-20 2002-10-30 Univ Strathclyde Drug delivery
US8349991B2 (en) 2005-04-19 2013-01-08 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
JP5745842B2 (ja) * 2007-06-19 2015-07-08 ストラトス ゲノミクス インコーポレイテッド 拡張によるハイスループット核酸配列決定

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919442A (en) * 1995-08-11 1999-07-06 Dendritech, Inc. Hyper comb-branched polymer conjugates
US20030072734A1 (en) * 1999-09-04 2003-04-17 Beiersdorf Ag Sulphonated comb polymers having a selected lithium/sodium ratio and preparations, in particular hair cosmetic preparations, based on such sulphonated comb polymers

Also Published As

Publication number Publication date
NO20083573L (no) 2008-10-17
IL225205A (en) 2017-03-30
US8173764B2 (en) 2012-05-08
EA200801729A1 (ru) 2009-02-27
EA025295B1 (ru) 2016-12-30
IL192869A (en) 2013-04-30
NO338835B1 (no) 2016-10-24
EP1979407A1 (en) 2008-10-15
AU2006336311A1 (en) 2007-07-26
IL192869A0 (en) 2009-02-11
EP1979407A4 (en) 2010-05-26
KR101263057B1 (ko) 2013-05-09
US20100260743A1 (en) 2010-10-14
BRPI0621291A2 (pt) 2011-12-06
KR20080098373A (ko) 2008-11-07
SI1979407T1 (sl) 2015-01-30
ES2523431T3 (es) 2014-11-25
CA2637560A1 (en) 2007-07-26
AU2006336311B2 (en) 2013-01-24
CN101400730A (zh) 2009-04-01
AP2008004573A0 (en) 2008-08-31
HK1127490A1 (en) 2009-09-25
JP2009528394A (ja) 2009-08-06
DK1979407T3 (en) 2014-11-03
EP1979407B1 (en) 2014-08-06
DK1979407T5 (en) 2014-12-01
CY1115715T1 (el) 2017-01-25
PL1979407T3 (pl) 2015-03-31
JP5027157B2 (ja) 2012-09-19
CA2637560C (en) 2013-11-26
PT1979407E (pt) 2014-10-16
NZ570484A (en) 2011-02-25
WO2007084126A1 (en) 2007-07-26
CN101400730B (zh) 2012-10-17

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