WO2008093723A1 - ＨｂＡ１ｃ測定方法 - Google Patents

ＨｂＡ１ｃ測定方法 Download PDF

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Publication number
WO2008093723A1
WO2008093723A1 PCT/JP2008/051390 JP2008051390W WO2008093723A1 WO 2008093723 A1 WO2008093723 A1 WO 2008093723A1 JP 2008051390 W JP2008051390 W JP 2008051390W WO 2008093723 A1 WO2008093723 A1 WO 2008093723A1
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WO
WIPO (PCT)
Prior art keywords
whole blood
storage
hba1c
specimen
amine oxidase
Prior art date
Application number
PCT/JP2008/051390
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English (en)
French (fr)
Inventor
Satoshi Yonehara
Norio Inamura
Original Assignee
Arkray, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray, Inc. filed Critical Arkray, Inc.
Priority to CN200880003239.7A priority Critical patent/CN101595230B/zh
Priority to JP2008522139A priority patent/JP5324918B2/ja
Priority to EP08704157.0A priority patent/EP2116611B1/en
Priority to US12/377,232 priority patent/US8008085B2/en
Publication of WO2008093723A1 publication Critical patent/WO2008093723A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/19—Halogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　保存後の全血検体であっても、採血直後と同等の測定精度を維持することができる、ＨｂＡ１ｃの測定方法の提供である。解糖系阻害剤の存在下で全血を保存し、保存後の前記全血試料にプロテアーゼを添加して前記全血試料中のヘモグロビンを切断する。そして、得られたヘモグロビン断片の糖化部分に、フルクトシルアミンオキシダーゼを作用させ、前記糖化部分とフルクトシルアミンオキシダーゼとの酸化還元反応を測定することにより、ＨｂＡ１ｃ糖化率を決定する。また、解糖系阻害剤存在下での全血保存に代えて、保存後の全血にＫＣｌ、Ｋ２ＳＯ４、ＫＮＯ、ＮａＣｌ、Ｎａ２ＳＯ４、ＮａＮＯ、ＭｇＣｌ２、ＭｇＳＯ４、Ｍｇ（ＮＯ）２等の強電解質物質を添加し、前記強電解質物質存在下でプロテアーゼ処理を行う。これらの方法によれば、全血保存による、ＨｂＡ１ｃ測定値の変動を回避できる。
PCT/JP2008/051390 2007-01-30 2008-01-30 ＨｂＡ１ｃ測定方法 WO2008093723A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN200880003239.7A CN101595230B (zh) 2007-01-30 2008-01-30 HbA1c测定方法
JP2008522139A JP5324918B2 (ja) 2007-01-30 2008-01-30 ＨｂＡ１ｃ測定方法
EP08704157.0A EP2116611B1 (en) 2007-01-30 2008-01-30 Measurement method for hba1c
US12/377,232 US8008085B2 (en) 2007-01-30 2008-01-30 Method of measuring HbA1c

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-020185 2007-01-30
JP2007020185 2007-01-30

Publications (1)

Publication Number Publication Date
WO2008093723A1 true WO2008093723A1 (ja) 2008-08-07

Family

ID=39674031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051390 WO2008093723A1 (ja) 2007-01-30 2008-01-30 ＨｂＡ１ｃ測定方法

Country Status (5)

Country Link
US (1) US8008085B2 (ja)
EP (1) EP2116611B1 (ja)
JP (1) JP5324918B2 (ja)
CN (1) CN101595230B (ja)
WO (1) WO2008093723A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019062890A (ja) * 2017-10-02 2019-04-25 アークレイ株式会社 糖化蛋白質の測定

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WO2018012607A1 (ja) * 2016-07-13 2018-01-18 キッコーマン株式会社 反応促進剤
CN109682796A (zh) * 2017-10-02 2019-04-26 爱科来株式会社 糖化蛋白质的测定
CN108130074B (zh) * 2018-01-15 2020-10-02 东南大学 一种制备高结晶性纳米氮化物荧光粉的方法
CN113009024B (zh) * 2018-12-29 2023-05-09 江山德瑞医疗科技有限公司 一种测定糖化血红蛋白中洗脱条件方法

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2019062890A (ja) * 2017-10-02 2019-04-25 アークレイ株式会社 糖化蛋白質の測定
JP7226955B2 (ja) 2017-10-02 2023-02-21 アークレイ株式会社 糖化蛋白質の測定

Also Published As

Publication number Publication date
EP2116611B1 (en) 2013-08-14
CN101595230A (zh) 2009-12-02
US8008085B2 (en) 2011-08-30
JP5324918B2 (ja) 2013-10-23
CN101595230B (zh) 2013-01-16
EP2116611A4 (en) 2012-01-18
JPWO2008093723A1 (ja) 2010-05-20
EP2116611A1 (en) 2009-11-11
US20100178659A1 (en) 2010-07-15

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