WO2009125219A3 - Markers of oocyte viability - Google Patents

Markers of oocyte viability Download PDF

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Publication number
WO2009125219A3
WO2009125219A3 PCT/GB2009/050339 GB2009050339W WO2009125219A3 WO 2009125219 A3 WO2009125219 A3 WO 2009125219A3 GB 2009050339 W GB2009050339 W GB 2009050339W WO 2009125219 A3 WO2009125219 A3 WO 2009125219A3
Authority
WO
WIPO (PCT)
Prior art keywords
oocyte
markers
concentration
develop
comparing
Prior art date
Application number
PCT/GB2009/050339
Other languages
French (fr)
Other versions
WO2009125219A2 (en
Inventor
Nicolas Michel Orsi
Nadia Gopichandran
Stuart Barber
Vinay Sharma
James Johnston Walker
Original Assignee
University Of Leeds
The Leeds Teaching Hospitals Nhs Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Leeds, The Leeds Teaching Hospitals Nhs Trust filed Critical University Of Leeds
Publication of WO2009125219A2 publication Critical patent/WO2009125219A2/en
Publication of WO2009125219A3 publication Critical patent/WO2009125219A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/53—Colony-stimulating factor [CSF]
    • G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5406—IL-4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5425—IL-9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5434—IL-12
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5443—IL-15
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/55—IL-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
    • G01N2333/56—IFN-alpha
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

There is disclosed a method of determining the potential of individual oocyte to develop into a viable embryo, which method comprises establishing the concentration of any one or more of the markers identified in Table 2 in the follicular fluid of a single follicle from which said oocyte is derived and comparing the concentrations obtained to a reference concentration range that is established by comparing the concentration of said one or more markers from one or more follicles containing a fertilisation competent oocyte(s), wherein differential levels of said markers from said follicle to be tested compared to the reference range at least at the 5% significance level is predictive of a reduced potential of said oocyte to develop into a viable embryo following fertilisation.
PCT/GB2009/050339 2008-04-07 2009-04-07 Markers of oocyte viability WO2009125219A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0806281A GB0806281D0 (en) 2008-04-07 2008-04-07 Markers of Oocyte viability
GB0806281.2 2008-04-07

Publications (2)

Publication Number Publication Date
WO2009125219A2 WO2009125219A2 (en) 2009-10-15
WO2009125219A3 true WO2009125219A3 (en) 2009-12-17

Family

ID=39433239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/050339 WO2009125219A2 (en) 2008-04-07 2009-04-07 Markers of oocyte viability

Country Status (2)

Country Link
GB (1) GB0806281D0 (en)
WO (1) WO2009125219A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5951487B2 (en) 2009-08-22 2016-07-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Imaging and evaluation of embryos, oocytes, and stem cells
CN103517676A (en) 2010-09-27 2014-01-15 奥克索金股份有限公司 Apparatus, method, and system for automated imaging and evaluation of embryos, oocytes, and stem cells
JP2014507664A (en) 2011-02-23 2014-03-27 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Method for detecting aneuploidy in human embryos
WO2014121200A1 (en) 2013-02-01 2014-08-07 Auxogyn, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
GB201314452D0 (en) 2013-08-13 2013-09-25 Ostara Biomedical Ltd Embryo implantation
AU2015240433B2 (en) * 2014-04-02 2020-11-26 Hudson Institute of Medical Research A prognostic assay for succes of assisted reproductive technology
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
CN108450005A (en) * 2015-09-30 2018-08-24 哈德逊医学研究所 A kind for the treatment of and method of prognosis
GB201517523D0 (en) 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
US20210022717A1 (en) * 2018-03-26 2021-01-28 Carmel Diagnostics Ltd. Follicular content storage

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009705A1 (en) * 2006-07-21 2008-01-24 Mithra Pharmaceuticals Nv/Sa Assay and kit for predicting implantation success in assisted fertilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009705A1 (en) * 2006-07-21 2008-01-24 Mithra Pharmaceuticals Nv/Sa Assay and kit for predicting implantation success in assisted fertilisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BILI H ET AL: "Cytokines in the human ovary: Presence in follicular fluid and correlation with leukotriene B4", JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol. 15, no. 2, February 1998 (1998-02-01), pages 93 - 98, XP002542351, ISSN: 1058-0468 *
KARAGOUNI EVDOKIA E ET AL: "Interleukin-1beta and interleukin-1alpha may affect the implantation rate of patients undergoing in vitro fertilization-embryo transfer", FERTILITY AND STERILITY, vol. 70, no. 3, September 1998 (1998-09-01), pages 553 - 559, XP002542352, ISSN: 0015-0282 *

Also Published As

Publication number Publication date
WO2009125219A2 (en) 2009-10-15
GB0806281D0 (en) 2008-05-14

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