WO2008004249A3 - An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts - Google Patents

An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2008004249A3
WO2008004249A3 PCT/IN2007/000269 IN2007000269W WO2008004249A3 WO 2008004249 A3 WO2008004249 A3 WO 2008004249A3 IN 2007000269 W IN2007000269 W IN 2007000269W WO 2008004249 A3 WO2008004249 A3 WO 2008004249A3
Authority
WO
WIPO (PCT)
Prior art keywords
clopidogrel
preparation
improved process
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IN2007/000269
Other languages
French (fr)
Other versions
WO2008004249A2 (en
Inventor
Reddy Manne Satyanarayana
Kumar Muppa Kishore
Rajan Srinivasan Thirumalai
Subba Reddy Karamala Rama
Original Assignee
Msn Lab Ltd
Reddy Manne Satyanarayana
Kumar Muppa Kishore
Rajan Srinivasan Thirumalai
Subba Reddy Karamala Rama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Lab Ltd, Reddy Manne Satyanarayana, Kumar Muppa Kishore, Rajan Srinivasan Thirumalai, Subba Reddy Karamala Rama filed Critical Msn Lab Ltd
Publication of WO2008004249A2 publication Critical patent/WO2008004249A2/en
Publication of WO2008004249A3 publication Critical patent/WO2008004249A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

The present invention provides an improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts, especially hydrogen chloride and hydrogen bromide by dissolving clopidogrel base in a suitable single or mixture of solvents followed by adding suitable acid and isolating the corresponding acid addition salts of clopidogrel compound of formula-1. Also provides an improved process for the preparation of clopidogrel hydrogen sulfate form-1; Formula (I).
PCT/IN2007/000269 2006-07-04 2007-07-03 An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts WO2008004249A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1158/CHE/2006 2006-07-04
IN1158CH2006 2006-07-04

Publications (2)

Publication Number Publication Date
WO2008004249A2 WO2008004249A2 (en) 2008-01-10
WO2008004249A3 true WO2008004249A3 (en) 2008-04-10

Family

ID=38895004

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000269 WO2008004249A2 (en) 2006-07-04 2007-07-03 An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts

Country Status (1)

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WO (1) WO2008004249A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL382055A1 (en) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Production method of crystalline form of clopidogrel 1 hydrogen sulphate
JP4367666B2 (en) 2007-11-09 2009-11-18 トヨタ自動車株式会社 Screw tightening device
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011055378A1 (en) * 2009-11-09 2011-05-12 Pharmazell Gmbh Improved process for preparation of clopiodogrel bisulfate crystalline form-1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066637A1 (en) * 2002-02-06 2003-08-14 EGIS Gyógyszergyár Rt. Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
US20040260110A1 (en) * 1997-10-06 2004-12-23 Andre Bousquet Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040260110A1 (en) * 1997-10-06 2004-12-23 Andre Bousquet Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates
WO2003066637A1 (en) * 2002-02-06 2003-08-14 EGIS Gyógyszergyár Rt. Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Synthesis of the stable polymorph I of Clopidogrel hydrobromide", RESEARCH DISCLOSURE (MASON PUBLICATIONS), vol. 490, no. 4, 1 February 2005 (2005-02-01), HAMPSHIRE, GB, XP007134723 *

Also Published As

Publication number Publication date
WO2008004249A2 (en) 2008-01-10

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