WO2009066326A3 - Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts - Google Patents
Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts Download PDFInfo
- Publication number
- WO2009066326A3 WO2009066326A3 PCT/IN2008/000773 IN2008000773W WO2009066326A3 WO 2009066326 A3 WO2009066326 A3 WO 2009066326A3 IN 2008000773 W IN2008000773 W IN 2008000773W WO 2009066326 A3 WO2009066326 A3 WO 2009066326A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- pharmaceutically acceptable
- acceptable salts
- prasugrel
- improved process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
The present invention relates to an improved process for the preparation of prasugrel compound of formula- 1 and its pharmaceutically acceptable salts thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IN2683/CHE/2007 | 2007-11-19 | ||
IN2683CH2007 | 2007-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009066326A2 WO2009066326A2 (en) | 2009-05-28 |
WO2009066326A3 true WO2009066326A3 (en) | 2009-07-30 |
Family
ID=40667947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2008/000773 WO2009066326A2 (en) | 2007-11-19 | 2008-11-18 | Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009066326A2 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009129983A1 (en) * | 2008-04-21 | 2009-10-29 | Ratiopharm Gmbh | Acid addition salts of prasugrel and pharmaceutical compositions comprising the same |
CZ2008748A3 (en) * | 2008-11-26 | 2010-06-02 | Zentiva, A. S | Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel) |
KR20110015254A (en) * | 2009-08-07 | 2011-02-15 | 한미홀딩스 주식회사 | Prasugrel disulfonate salts and crystals thereof |
CN101993447A (en) * | 2009-08-26 | 2011-03-30 | 浙江华海药业股份有限公司 | Method for synthesizing Prasugrel artificially |
KR20110024057A (en) * | 2009-09-01 | 2011-03-09 | 한미홀딩스 주식회사 | Novel polymorphic prasugrel hydrogensulfate |
US20120202066A1 (en) * | 2009-10-07 | 2012-08-09 | Manne Satyanarayana Reddy | Processes For Preparing Prasugrel And Pharmaceutically Acceptable Salts Thereof |
CZ302833B6 (en) * | 2009-11-16 | 2011-11-30 | Zentiva, K. S. | Hydrobromide of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process for preparing thereof |
CZ2009763A3 (en) | 2009-11-16 | 2011-05-25 | Zentiva, K. S. | Process for preparing extreme pure 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and its novel pharmaceutically acceptable salts |
CZ2009762A3 (en) | 2009-11-16 | 2011-05-25 | Zentiva, K. S. | Novel salts of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process of their preparation |
CZ2009828A3 (en) | 2009-12-09 | 2011-06-22 | Zentiva, K.S. | Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (prasugrelu hydrochloride in polymorphous B form |
HU229035B1 (en) * | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel |
HU229031B1 (en) | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel and its intermediate |
CN101735241A (en) * | 2009-12-24 | 2010-06-16 | 浙江普洛家园药业有限公司 | Prasugrel intermediate and preparation method thereof |
ES2533681T3 (en) | 2010-04-08 | 2015-04-14 | Teva Pharmaceutical Industries Ltd. | Crystal forms of Prasugrel salts |
CN101812070B (en) * | 2010-04-16 | 2012-01-11 | 海南美大制药有限公司 | Prasugrel compound and new preparation method thereof |
WO2012001486A1 (en) | 2010-06-28 | 2012-01-05 | Mayuka Labs Pvt. Ltd. | An improved process for the preparation of prasugrel hydrochloride and its intermediates |
CN101948479B (en) * | 2010-09-29 | 2013-01-30 | 横店集团家园化工有限公司 | Prasugrel intermediate and preparation method thereof |
HUP1000565A2 (en) | 2010-10-22 | 2012-05-02 | Egis Gyogyszergyar Nyrt | Process for the preparation of pharmaceutically active compound and intermediers |
CN101985451B (en) * | 2010-11-02 | 2012-04-25 | 北京赛科药业有限责任公司 | Preparation method of prasugrel intermediate |
CN101985450B (en) * | 2010-11-02 | 2012-07-11 | 北京赛科药业有限责任公司 | Prasugrel salt and preparation method thereof |
CN102002056B (en) * | 2010-11-02 | 2012-04-25 | 北京赛科药业有限责任公司 | Method for preparing intermediate of prasugrel |
CN102101827B (en) * | 2010-11-15 | 2013-07-03 | 山东新华制药股份有限公司 | Method for preparing Prasugrel intermediate alpha-cyclopropyl carbonyl-2-fluorobenzyl halide |
CN102329326B (en) * | 2011-10-20 | 2014-04-09 | 天津药物研究院 | Pyrrole derivatives and preparation method and application thereof |
CN102503954B (en) * | 2011-10-20 | 2013-11-27 | 天津药物研究院 | Imidazole derivative and preparation method and application thereof |
CN103304577A (en) * | 2012-03-07 | 2013-09-18 | 辽宁亿灵科创生物医药科技有限公司 | Prasugrel acid addition salts, and preparation methods and medicinal applications thereof |
CN103570741B (en) * | 2012-07-26 | 2017-06-09 | 石药集团中奇制药技术(石家庄)有限公司 | Prasugrel novel crystal forms and preparation method thereof |
CN103848844A (en) * | 2012-12-07 | 2014-06-11 | 天津市汉康医药生物技术有限公司 | Prasugrel salt-forming compound and preparation method thereof |
HU230649B1 (en) | 2013-01-24 | 2017-05-29 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Improved process for producing pharmaceutical agent prasugrel and 2-(2-fluorophenyl)-1-cyclopropylethanone intermediate |
CN104418718B (en) * | 2013-08-28 | 2018-04-13 | 山东新时代药业有限公司 | A kind of 2 bromine 2 of cyclopropyl(2 fluorophenyls)The preparation method of ethyl ketone |
CN105884793A (en) * | 2016-06-09 | 2016-08-24 | 青岛辰达生物科技有限公司 | Preparation method of antiplatelet medicine Prasugrel |
HU231079B1 (en) | 2016-06-23 | 2020-06-29 | Richter Gedeon Nyrt. | Process for the preparation of high-purity prasugrel by the elimination of the bromopentyl impurity |
CN110950885B (en) * | 2019-12-06 | 2022-04-15 | 南京恒道医药科技有限公司 | Method and device for continuously preparing prasugrel intermediate through countercurrent extraction |
CN112964794B (en) * | 2019-12-13 | 2022-10-18 | 武汉武药制药有限公司 | Method for separating and detecting 4,5,6,7-tetrahydrothiophene [3,2-c ] pyridine hydrochloride and related substances thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515951A (en) * | 1980-11-28 | 1985-05-07 | Sanofi | Preparation of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one compounds |
US4740510A (en) * | 1985-01-31 | 1988-04-26 | Sanofi (S.A.) | Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors |
WO2007114526A1 (en) * | 2006-04-06 | 2007-10-11 | Daiichi Sankyo Company, Limited | Process for producing high-purity prasugrel and acid addition salt thereof |
-
2008
- 2008-11-18 WO PCT/IN2008/000773 patent/WO2009066326A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515951A (en) * | 1980-11-28 | 1985-05-07 | Sanofi | Preparation of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one compounds |
US4740510A (en) * | 1985-01-31 | 1988-04-26 | Sanofi (S.A.) | Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors |
WO2007114526A1 (en) * | 2006-04-06 | 2007-10-11 | Daiichi Sankyo Company, Limited | Process for producing high-purity prasugrel and acid addition salt thereof |
Non-Patent Citations (1)
Title |
---|
DOGGRELL, S.A. ET AL.: "CS-747 and R-99224", DRUGS FUT, vol. 26, no. 9, 2001, pages 835 - 841 * |
Also Published As
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