US608612A - Friedbich wiliielm klever - Google Patents
Friedbich wiliielm klever Download PDFInfo
- Publication number
- US608612A US608612A US608612DA US608612A US 608612 A US608612 A US 608612A US 608612D A US608612D A US 608612DA US 608612 A US608612 A US 608612A
- Authority
- US
- United States
- Prior art keywords
- oils
- per cent
- klever
- wiliielm
- friedbich
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002480 mineral oil Substances 0.000 description 36
- 239000003513 alkali Substances 0.000 description 20
- 239000000126 substance Substances 0.000 description 18
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 10
- 235000010446 mineral oil Nutrition 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000003518 caustics Substances 0.000 description 8
- 239000010685 fatty oil Substances 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 230000001590 oxidative Effects 0.000 description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drugs Drugs 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- LHGVFZTZFXWLCP-UHFFFAOYSA-N Guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 4
- 210000003491 Skin Anatomy 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 229960002126 Creosote Drugs 0.000 description 2
- 229960001867 Guaiacol Drugs 0.000 description 2
- 229940097789 Heavy mineral oil Drugs 0.000 description 2
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
- 229960004873 LEVOMENTHOL Drugs 0.000 description 2
- 235000006173 Larrea tridentata Nutrition 0.000 description 2
- 240000007588 Larrea tridentata Species 0.000 description 2
- 229940041616 Menthol Drugs 0.000 description 2
- 241000779819 Syncarpia glomulifera Species 0.000 description 2
- 229940036248 Turpentine Drugs 0.000 description 2
- 229940099259 Vaseline Drugs 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- LGLFFNDHMLKUMI-UHFFFAOYSA-N crystal violet cation Chemical compound C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)N(C)C)=C1C=CC(=[N+](C)C)C=C1 LGLFFNDHMLKUMI-UHFFFAOYSA-N 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000295 fuel oil Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229960003172 iodoform Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000001739 pinus spp. Substances 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000000246 remedial Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 200000000019 wound Diseases 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
Definitions
- This invention relates to a process for renderin g in edicinal preparations which by themselves are insoluble in mineral oils soluble in the latter and to impart thereto the property of forming emulsions with the secretions of the skin or of wounds. At the same time the property is imparted to the medicines of being absorbable by the skin, which has not been hitherto accomplished, while in addition any caustic properties that may be possessed by the medicines are either completely neu-V tralized or reduced in a very great degree.
- the medicines whose solution in mineral The process is carried out in the following manner:
- the mineral oil to be treated is mixed with oxygen carriers in particular alkalies, of which there are preferably used caustic alkalies or alkaline carbonates either in the solid form or in solution, in which latter case the solutions are advantageously made as concentrated as possible.
- the mixture is heated in a pan, if necessary, under stirring, while at the same time oxygen in pressure. If pure oxygen is employed, it is advisable to employ the compressed gas of commerce.
- caustic alkalies H to be added may vary between two and seven 'per cent. of sodium or potassium hydroiiid.
- the duration of the heating, and the necessary pressure will vary according to the na ture of the oils employed.
- the necessary pressure varies according to the nature of the mineral oils Within wide limits, such as between seven to thirty atmospheres.
- the temperature can be raised up to 200 centigrade.
- the proportions must be so chosen that the product obtained forms an emulsion with water, which is determined by taking a sample and testing its behavior 5 with water.
- mineral oils the socalled heavy oils of the specific gravity of 0.890 and 0.900, as also the purified paraffin-oils, and the so-callec Vaseline-oils have been found suitable for the purpose of this invention.
- the solution of the medicinal compounds in the vasogenes is effected in the known manner by digestion and the like, if necessary under pressure, under the above-named conditions.
- the following proportions of solution are employed: iodin, one to six to twenty per cent; iodoform, one and onehalf per cent. ichthyol, ten to fifty per cent. euealyptol, twenty per cent; turpentine, twenty per cent; creosote, twenty to fifty per cent. guaiacol, twenty to fifty per cent. creolin, five to fifty per cent; pyoctanin, two per cent.
- Chloroforrncamphor is soluble in equal proportions, while menthol can be dissolved in any desired proportions.
- oxygenated Vaseline prepared as described is mixed with the usual salve bases, such as wax or ceresin.
- a process for preparing solutions in mineral oils of substances insoluble therein which consists in mixing a fatty body and an alkali with the mineral oil, oxidizing the mixture, and adding thereto the substance to be dissolved.
- a process for preparing solutions in mineral oils of substances insoluble therein which consists in mixing a fatty acid and an alkali with the mineral oil, oxidizing the mixture and adding thereto the substance to be dissolved.
- a process for preparing solutions in mineral oils of substances insoluble therein which consists in mixing an alkali with a heavy mineral oil (Vaseline-oil) oxidizing the mixture, and adding thereto the substance to be dissolved.
- a heavy mineral oil Vaseline-oil
- composition of matter consisting of an oxidized mineral oil and a remedial agent normally insoluble in said oil, held in solution therein, substantially as and for the purpose set forth.
Description
hlllihl) tarps area trims,
FRIEDRICH WILIIELM KLEVER, OF COLOGNE, GERMANY, ASSIGNOR TO EDWARD THEODORE PEARSON, OF HAMBURG, GERMANY.
OlNTMENT BASE AND METHOD OF MAKING SAME.
SPECIFICATION forming part of Letters Patent No. 608,612, dated August 9, 1898.
Application filed. December 13, 1897.' Serial No. 661,713.
(No specimens.) Patented in England June 24, 1893, No. 12,446,
and February 26, 1897,110. 5,256; in Belgium June 26, 1893,1To. 105,269; in Austria-Hungary March 3,1894, No.50,260
and No. 79,928, and in Italy August 10, 1896, No. 13,688.
To all whom it may concern.-
Be it known that I, FRIEDRICH WILHELM KLEVER, a subject of the German Emperor, and a resident of Cologne, in the German Empire, have invented certain new and useful Improvements in the Manufacture of Solutions of Medicinal Preparations in a Liquid Prepared from Mineral Oils, (for which patents have been obtained in Great Britain, No. 12,446, dated June 24, 1893, and No. 5,256, dated February 26, 1897; in Belgium, No. 105,269, dated June 26, 1893; in Austria-Hungary, No. 50,260 and No. 79,928, dated March 3, 1894, and in Italy, No. 13,688, dated August 10, 1896,) of which the following is a specification.
This invention relates to a process for renderin g in edicinal preparations which by themselves are insoluble in mineral oils soluble in the latter and to impart thereto the property of forming emulsions with the secretions of the skin or of wounds. At the same time the property is imparted to the medicines of being absorbable by the skin, which has not been hitherto accomplished, while in addition any caustic properties that may be possessed by the medicines are either completely neu-V tralized or reduced in a very great degree.
The medicines whose solution in mineral The process is carried out in the following manner: The mineral oil to be treated is mixed with oxygen carriers in particular alkalies, of which there are preferably used caustic alkalies or alkaline carbonates either in the solid form or in solution, in which latter case the solutions are advantageously made as concentrated as possible. The mixture is heated in a pan, if necessary, under stirring, while at the same time oxygen in pressure. If pure oxygen is employed, it is advisable to employ the compressed gas of commerce.
any form is introduced, if necessary, under The quantity of caustic alkalies H to be added may vary between two and seven 'per cent. of sodium or potassium hydroiiid.
It is of advantage to choose Many mineral oils cannot be brought into the requisite form for the before-mentioned purpose by the above-described treatment.
In such cases it is advisable to add some fatty oils or fatty acids to the mineral oils treated With the alkalies. Such mineral oils are taken with advantage in which the addition of fatty oils or fatty acids need not exceed twenty per cent.
lVith mineral oils to which fatty oils or fatty acids have been added it is advisable instead of adding pure caustic alkalies or pure solutions thereof to employ an addition of ammonia or an addition of this together with the other alkalies in the above stated proportions.
In order to avoid too great viscosity of the finished product, an addition of alcohol up to two per cent. is permissible.
The quantity'of the necessary additions,
the duration of the heating, and the necessary pressure will vary according to the na ture of the oils employed. The necessary pressure varies according to the nature of the mineral oils Within wide limits, such as between seven to thirty atmospheres.
The temperature can be raised up to 200 centigrade. The proportions must be so chosen that the product obtained forms an emulsion with water, which is determined by taking a sample and testing its behavior 5 with water.
Sometimes the combination of the oxygen with the mineral oils mixed with fatty oils or fatty acids can be eifected by simply shak= ing together with air after the said additions have been made. Of the mineral oils the socalled heavy oils of the specific gravity of 0.890 and 0.900, as also the purified paraffin-oils, and the so-callec Vaseline-oils have been found suitable for the purpose of this invention.
The solution of the medicinal compounds in the vasogenes is effected in the known manner by digestion and the like, if necessary under pressure, under the above-named conditions. Of the substances which when dissolved in vasogen show the above-described properties of forming an emulsion and becoming absorbed the following proportions of solution are employed: iodin, one to six to twenty per cent; iodoform, one and onehalf per cent. ichthyol, ten to fifty per cent. euealyptol, twenty per cent; turpentine, twenty per cent; creosote, twenty to fifty per cent. guaiacol, twenty to fifty per cent. creolin, five to fifty per cent; pyoctanin, two per cent.
Chloroforrncamphor is soluble in equal proportions, while menthol can be dissolved in any desired proportions.
If it is desired to make a salve, then from three to ten per cent. of oxygenated Vaseline prepared as described is mixed with the usual salve bases, such as wax or ceresin.
Having now particularly described and ascertained the nature of my invention and the manner in which the same is to be performed, I declare that what I claim is 1.. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing an alkali with the mineral oil, oxidizing the mixture and adding thereto the substance to be dissolved.
2. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing a fatty body and an alkali with the mineral oil, oxidizing the mixture, and adding thereto the substance to be dissolved.
3. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing a fatty acid and an alkali with the mineral oil, oxidizing the mixture and adding thereto the substance to be dissolved.
4:. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing an alkali with a heavy mineral oil (Vaseline-oil) oxidizing the mixture, and adding thereto the substance to be dissolved.
5. As a new article of manufacture, a composition of matter consisting of an oxidized mineral oil and a remedial agent normally insoluble in said oil, held in solution therein, substantially as and for the purpose set forth.
Signed at Cologne, in the German Empire, this 24th day of November, 1807.
FRIEDRICH WILHELM K LEVER.
\Vitnesses:
FRANZ GREIN, WILLIAM H. MADDEN.
Publications (1)
Publication Number | Publication Date |
---|---|
US608612A true US608612A (en) | 1898-08-09 |
Family
ID=2677231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US608612D Expired - Lifetime US608612A (en) | Friedbich wiliielm klever |
Country Status (1)
Country | Link |
---|---|
US (1) | US608612A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3353970A (en) * | 1964-12-21 | 1967-11-21 | Scott Chemical And Welding Pro | Metal spatter-fouling inhibiting material and method |
US5753270A (en) * | 1987-09-16 | 1998-05-19 | Patrick A. Beauchamp | Topical treatment of diseased skin disorders |
-
0
- US US608612D patent/US608612A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3353970A (en) * | 1964-12-21 | 1967-11-21 | Scott Chemical And Welding Pro | Metal spatter-fouling inhibiting material and method |
US5753270A (en) * | 1987-09-16 | 1998-05-19 | Patrick A. Beauchamp | Topical treatment of diseased skin disorders |
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