US20090306520A1 - Quantitative methods for obtaining tissue characteristics from optical coherence tomography images - Google Patents
Quantitative methods for obtaining tissue characteristics from optical coherence tomography images Download PDFInfo
- Publication number
- US20090306520A1 US20090306520A1 US12/455,523 US45552309A US2009306520A1 US 20090306520 A1 US20090306520 A1 US 20090306520A1 US 45552309 A US45552309 A US 45552309A US 2009306520 A1 US2009306520 A1 US 2009306520A1
- Authority
- US
- United States
- Prior art keywords
- tissue
- oct
- attenuation
- data
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
Definitions
- This invention provides methods for tissue characterization using optical coherence tomography. Specifically, in part, such characterization can be performed by measuring a tissue's optical and image properties.
- OCT optical coherence tomography
- TD-OCT time domain
- OFDI optical frequency domain imaging
- OCT imaging of portions of a patient's body provides a useful tool for doctors to determine the best type and course of treatment.
- imaging of coronary arteries by intravascular OCT may reveal the location of a stenosis, the presence of vulnerable plaques, or the type of atherosclerotic plaque.
- drug therapy e.g., cholesterol-lowering medication
- a catheter-based therapy like angioplasty and stenting
- an invasive surgical procedure like coronary bypass surgery.
- OCT is also very useful for drug development in animal and clinical trials.
- intima has a consistent layered structure consisting of intima, media and adventia.
- the intima becomes pathologically thickened and may contain plaques composed of different types of tissues, including fiber, proteoglycans, lipid and calcium, as well as macrophages and other inflammatory cells.
- tissue types have different optical properties that can be measured by OCT.
- the plaques that are believed to be most pathologically significant are the so-called vulnerable plaques that have a fibrous cap with an underlying lipid pool.
- an optical probe mounted on a catheter is carefully maneuvered to a point of interest such as within a coronary blood vessel.
- the optical beams are then transmitted and the backscattered signals are received through coherent detection using an interferometer.
- An image (2D or 3D) is then reconstructed using well-known techniques. This image is then analyzed visually by a cardiologist to assess pathological features, such as vessel wall thickening and plaque composition.
- tissue type is identified by its appearance on the screen, errors may occur in the analysis because certain information (such as tissue type) cannot be readily discerned.
- the standard OCT image only contains the intensity information of the OCT signals. Small changes in the optical properties that influence the OCT signals cannot be readily discerned. Thus, it would be advantageous to have an OCT system and method to measure the optical properties and use them to aid scientists and clinicians. The present invention addresses this need.
- the invention relates to a method and apparatus for determining properties of a tissue or tissues imaged by OCT.
- the backscatter and attenuation of the OCT optical beam is measured and based on these measurements an indicium, such as color, is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion.
- the image is then displayed with the indicia and a user can then determine the tissue characteristics.
- the tissue characteristics can be classified automatically by a program given the combination of backscatter and attenuation values.
- the invention relates to a method for identifying tissue components in situ.
- the method comprises the steps of: taking an OCT image of a tissue in situ; measuring the attenuation and backscatter at a point in the OCT image; and determining the composition of the tissue at a location in the tissue corresponding to the point in the OCT image in response to the measured attenuation and backscatter.
- the method further comprises mapping a pair of coordinates in backscatter-attenuation space to an indicium of the value of the pair of coordinates in the backscatter-attenuation space.
- the indicium is a color.
- the method further comprises displaying the indicium corresponding to the measured attenuation and backscatter at the point in the OCT image.
- the invention in another aspect relates to a system for identifying tissue components in situ.
- the system comprises an OCT subsystem for taking an OCT image of a tissue in situ; a processor in communication with the OCT subsystem for measuring the attenuation and backscatter at a point in the OCT image and determining the composition of the tissue at a location in the tissue corresponding to the point in the OCT image in response to the measured attenuation and backscatter; and a display for displaying the OCT image and an indicium corresponding to the measured attenuation and backscatter at the point in the OCT image.
- the invention in another aspect, relates to a processor-implemented method for identifying tissue components in situ.
- the method includes the steps of (a) collecting an OCT dataset of a tissue sample in situ using a probe; (b) measuring an attenuation value and a backscattering value at a point in the tissue sample; and (c) determining a tissue characteristic at a location in the tissue sample corresponding to an image location in an OCT image formed from the OCT dataset in response to the measured attenuation value and backscattering value.
- the method can include the further step of mapping a pair of coordinates in backscatter-attenuation space to an indicium of the value of the pair of coordinates in the backscatter-attenuation space.
- the method can include the further step of displaying the indicium corresponding to the measured attenuation and backscatter at the point in the OCT image.
- the tissue characteristic can be selected from the group consisting of cholesterol, fiber, fibrous, lipid pool, lipid, fibrofatty, calcium nodule, calcium plate, calcium speckled, thrombus, foam cells, and proteoglycans.
- the indicium can be, for example, a color.
- the indicium can also be selected from the group consisting of an over-lay, a colormap, a texture map, and text.
- the method can include the further step of classifying tissue type using a property selected from the group consisting of backscattering, attenuation, edge sharpness, and texture measurements.
- the method can include the further step of correcting a focusing effect to improve tissue type classification.
- the method can include the further step of applying angular intensity correction to account for an attenuation effect, such as, for example, a blood-related attenuation effect.
- the method can include the further step of determining a tissue characteristic using a technique selected from the group consisting of boundary detection, lumen location, and OCT location depth.
- the invention in another aspect, relates to a system for identifying tissue components in situ.
- the system includes (a) an OCT subsystem for taking an OCT image of a tissue in situ; (b) a processor in communication with the OCT subsystem for measuring the attenuation and backscatter at a point in the OCT image and determining a tissue characteristic of the tissue at a location in the tissue corresponding to the point in the OCT image in response to the measured attenuation and backscatter; and (c) a display for displaying the OCT image and an indicium corresponding to the measured attenuation and backscatter at the point in the OCT image.
- the tissue characteristic can be selected from the group consisting of cholesterol, fiber, fibrous, lipid pool, lipid, fibrofatty, calcium nodule, calcium plate, calcium speckled, thrombus, foam cells, and proteoglycans.
- the invention in another aspect relates to an optical coherence tomography system for identifying tissue characteristics of a sample.
- the computer system includes a detector configured to receive an optical interference signal generated from scanning a sample and converting the optical interference signal to an electrical signal; an electronic memory device and an electronic processor in communication with the memory device and the detector.
- the memory device can include instructions that, when executed by the processor, cause the processor to: analyze the electrical signal and generate a plurality of datasets corresponding to the sample, wherein one of the plurality of datasets comprises backscattering data; compare the backscattering data to a first threshold, the backscattering data mapping to a first location in the sample; and if the backscattering data exceeds the first threshold, characterize the first location in the sample as having a first tissue characteristic.
- the processor is further caused to generate an OCT image of the sample such that the first tissue characteristic is identified and displayed relative to the first location.
- the first tissue characteristic can be selected from the group consisting of cholesterol, fiber, fibrous, lipid pool, lipid, fibrofatty, calcium nodule, calcium plate, calcium speckled, thrombus, foam cells, and proteoglycan.
- at least one of the plurality of datasets includes OCT scan data, attenuation data, edge sharpness data, texture parameters, or interferometric data.
- FIG. 1 is a schematic view of a generalized OCT data acquisition system in accordance with an embodiment of the invention.
- FIG. 2 is a schematic view of a cross-section of a lumen with an imaging probe disposed therein with a semi-transparent layer according to an embodiment of the invention.
- FIG. 3A shows optical properties, geometric information and parameters for a beam of electromagnetic waves used to collect OCT data.
- FIGS. 3B and 3C show plots of relative intensity and gain, respectively, as a function of beam distance from the probe tip used to perform OCT data collection according to an embodiment of the invention.
- FIG. 4A shows a cross-section of a lumen with an imaging probe disposed therein according to an embodiment of the invention.
- FIG. 4B shows an exemplary angular intensity profile with respect to rotational angle of the probe according to an embodiment of the invention.
- FIGS. 5A-5B illustrates the results from the application of an exemplary method of OCT image denoising according to an illustrative embodiment of the invention.
- FIG. 5A shows the image before denoising and
- FIG. 5B shows the same OCT image after the application of the denoising method.
- FIG. 6A illustrates OCT scan data being processed using a window as part of a method for optical property extraction according to an embodiment of the invention.
- FIG. 6B illustrates OCT scan data being processed to define a region of interest according to an embodiment of the invention.
- FIG. 6C is data plot with a linear portion used to model certain optical properties from a set of OCT data according to an embodiment of the invention.
- FIG. 7 illustrates a lumen cross-section and demonstrates the automatic detection of a lumen surface and an OCT penetration limit of interest according to an embodiment of the invention.
- FIG. 8 illustrates a plotted OCT dataset suitable for performing tissue boundary localization using piece-wise regression on a one-dimensional OCT axial scan according to an embodiment of the invention.
- FIG. 9 illustrates a two-dimensional cross-section of a lumen obtained using an OCT scan such that the tissue boundary localization was generated using Canny's edge detector method.
- FIG. 10A is a diagram of a section of lumen wall showing the interaction of the beam at two locations with the various tissues in the wall.
- FIGS. 10B and 10C are schematic diagrams that illustrate the dimensions and variables used in a method of extracting attenuation/backscattering coefficients from a multi-layered tissue object shown in FIG. 10A according to an embodiment of the invention.
- FIG. 11A includes four image data plots showing exemplary tissue characterization coefficients relating to backscattering and attenuation data according to an embodiment of the invention.
- FIG. 11B shows a color-map plot of attenuation and backscattering data suitable for implementing a method for distinguishing different tissue properties according to an embodiment of the invention.
- FIG. 11C shows two exemplary OCT images depicting different tissue properties that have been enhanced using the color-map shown in FIG. 11B .
- FIGS. 11D-11E show hatched versions of FIGS. 11B and 11C .
- FIGS. 12A and 12B illustrate, respectively, methods of tissue characterization by histological preparation and OCT data processing in accordance with embodiments of present invention.
- FIG. 13A shows an example histology image with mapped tissue types according to an embodiment of the invention.
- FIG. 13B shows an OCT image in which the tissue types and data identified in FIG. 13A have been mapped and identified with boundaries according to an embodiment of the invention.
- FIG. 14 shows a plot of attenuation data versus backscattering data with respect to certain tissue properties obtained from real human atherosclerosis plaques using methods described in FIGS. 12A-12B .
- FIG. 15A shows a plot of attenuation data versus backscattering data suitable for use with a tissue characterization discriminant method that compares the tissue properties of region of interest to the tissue properties populated in a database.
- FIG. 15B illustrates an exemplary OCT tissue characterization image in which a computer texture overlay is used to describe regions of interest according to an embodiment of the invention.
- FIG. 16A is a plot depicting the backscattering vs. attenuation data shown in FIG. 14 according to an embodiment of the invention.
- FIGS. 16B-16C are plots depicting edge sharpness and texture, respectively, as measured for a boundary of interest according to an embodiment of the invention.
- the invention relates to methods for tissue characterization of vessel walls using optical methods based on what is generally termed low coherence interferometry (LCI), such as, but not limited to optical coherence tomography (OCT) whether in the time or Fourier domain.
- LCI low coherence interferometry
- OCT optical coherence tomography
- the methods described herein solve the problems encountered in semi-automatic or automatic tissue characterization application such as optical calibration, artifact removal, generating accurate optical and spatial parameter measurement from regions of interests, tissue segmentations, and statistical discriminant analysis of tissue types.
- discriminant analysis refers to classifying images or data into different classes.
- the present invention provides methods for analyzing OCT data and images to characterize biological tissues. Although methods described herein may pertain specifically to vascular tissues, the methods also apply to tissues in other organs of the body, including tissues in the gastrointestinal, pulmonary, and reproductive tracts. Embodiments of the present invention operate in conjunction with an OCT system and a computing device that include characterization software and a decision database as discussed below with respect to FIG. 1 .
- the OCT console and OCT probe are used to acquire raw OCT data and demodulated data from a blood vessel.
- demodulated data refers to OCT images, such as grayscale images, or the underlying data associate with such images.
- the OCT data is received by the computing device such as a processor and used to create an OCT image on which numerical, text or graphical information about tissue characteristics are displayed.
- embodiments of the invention are used to evaluate the walls of certain lumens and tissues accessible by an OCT probe.
- tissue images or tissue data sets can include, but are not limited to plaques, lipid pools, and stent placement zones.
- histology images of a sample are used to automate an OCT data-based characterization of the same and unrelated samples.
- reference data e.g., normal tissue type data from histology reviewed samples
- the characterization software implements some or all of the steps shown in FIG. 12A . However, this software can implement other methods as appropriate and discussed herein.
- one embodiment of the characterization software is based on manual selection of regions-of-interest in a histology image.
- the actual histology data is evaluated to identify different tissue types.
- these identified tissue evaluations are be compared to OCT images obtained with respect to the same sample tissue.
- training sets are created to allow some of the software and programming logic described herein to automatically characterize tissue types and structures in an OCT image. For example, if tissue layer A is identified in the histology image, the same region of interest A′ can be identified in the corresponding OCT image. This process can be repeated to build a database of information used to locate different tissues in an OCT image. Backscattering and attenuation data can be used as outlined below to facilitate this process.
- Other embodiments of the methods described herein also include image preprocessing steps (such as focus correction), and optical property measurement.
- one or more tissue samples are first interrogated using OCT such that OCT scan data is collected. Once the scan data is processed, the resulting OCT images relating to the tissue samples are calibrated and corrected for imaging artifacts. Next, the tissue sample is cross-sectioned to create a histology image designating different parts of the image as composed of different elements or features. The tissue samples are processed using a histological method (such as dye staining), and digitized to create a histology image or histology data set.
- OCT OCT scan data
- the resulting OCT images relating to the tissue samples are calibrated and corrected for imaging artifacts.
- the tissue sample is cross-sectioned to create a histology image designating different parts of the image as composed of different elements or features.
- the tissue samples are processed using a histological method (such as dye staining), and digitized to create a histology image or histology data set.
- the OCT images are image mappings of the backscattered signal that reaches the OCT probe after being reflected from the OCT scan of the sample.
- the histology images are digitized microscopic images of real tissue sample undergone dye staining, i.e., the histology images are color images showing the dye distribution. Since the dyes bind to certain molecules and tissue types preferentially, the histology images map the molecules/tissue types in a tissue sample.
- a histology image typically includes data regarding tissue or a tissue structure or the image created from such underlying data.
- the histology image allows operators to identify tissue types (or characterizations) and regions of interest (ROIs).
- the OCT images are matched or mapped to the histology image. In one embodiment, the mapping is done manually.
- the characterization software then identifies a corresponding region on the OCT image.
- the characterization software then calculates at least one of the tissue optical properties or spatial features, the result of which is stored in the database.
- Statistical analysis is then applied to form a discriminant analysis method using both the OCT data and the tissue types identified in histology.
- FIG. 1 is a schematic illustration of a generalized view of an OCT imaging system 10 .
- the imaging system typically includes an interferometer 12 and an optical source 14 , for example, a broadband light source, or a wavelength-swept source that provides optical beam to both sample arm 16 and reference arm 18 .
- the sample arm 16 delivers the optical beam to tissue through an optional scanning apparatus such as an OCT probe.
- the optical scanning apparatus is a rotational transducer attached to the end of the sample arm and is carefully maneuvered through the patient's body to the region of interest.
- the scanning probe provides a substantially collimated beam to the vessel walls.
- the reference arm has a built-in known reflector, which may be located either at a separate optical path or at a common path as sample arm but at a slightly different location. The backscattered light signals from both the sample arm and the reference arm are recombined at the optical interferometer 12 .
- the combined optical interference signal is converted to electrical signal by the optical detector (or detector arrays) 20 .
- the signal is then used to construct images.
- the detector is in electrical communication with a processing and analysis subsystem 21 in one embodiment.
- the subsystem can include a processor 22 , a data acquisition module 24 , and an analysis software application 26 .
- the processor 22 is a portion of a computer system or other processor-based device executes various software programs or program logic such as data acquisition 24 and data analysis modules 26 .
- the acquisition and analysis system elements are hardware modules.
- the software includes characterization software and graphic user interface for displaying regions of interest as described below.
- the processor 22 is in communication with memory (not shown) and a database 28 .
- the database is used to store all types of data and participate in various processing phases and stages as outlined below.
- OCT is currently the most widespread variant of this group of imaging systems.
- the sample arm of commercially available OCT system has many configurations, including microscope, forward-looking endoscope and side-looking endoscope.
- OCT with side-looking endoscope is used as a non-limiting example for describing this invention below.
- an optical probe is mounted in an endoscopic catheter at the sample arm 16 .
- the substantially collimated beam exits from the optical probe mounted on the side.
- the catheter and the probe are rotated to generate 2D scan and can also be pulled or advanced while rotating to generate 3D scan.
- the OCT signal can be described as the light collected from a discrete light imaging volume. Signals from discrete locations within the sample include the image data set. The signal detected from any location is determined by the scattering element's size, refractive indices, density, geometrical arrangement, in addition to characteristics of the optical imaging system. Since different tissues have different chemical composition and microscopic structure, their appearances differ in OCT images. Qualitative differences in appearance have been used clinically for identifying and characterizing plaques. However, this qualitative approach requires extensive experience and is prone to instrumental and human errors. To assist in tissue characterization, the present invention provides various means to incorporate quantitative measurements. In some embodiments, this tissue characterization is performed automatically using the processor 22 and characterization software.
- the characterization software inputs the OCT data, calibrates the signal strength, enhances data quality via filtering, corrects imaging artifacts, and calculates parameters for all tissue regions or specific regions of interest identified by operators, and uses the parameters stored in database to identify tissue type or characterization.
- the characterization software identifies at least one of the tissue optical properties or spatial features from OCT data. The tissue optical properties are calculated and displayed. The individual tissue optical properties are displayed either individually or in combination.
- the optical parameters of the tissue can be extracted by fitting the data based on single-scatterer theory.
- the optical parameters can be extracted by models, such as the extended Huygens-Fresnel (ELF) theory that include multiple-scatterer effect.
- ELF extended Huygens-Fresnel
- P(z) is the power of OCT signal received.
- the OCT signal power P(z) collected from a homogeneous sample, from depth z 0 to z 1 is described by:
- z is the depth into the sample
- K is the delivered incident power
- A(z, ⁇ ) is the optical system efficiency
- T(z 0 ) is the optical transmission efficiency from tissue surface to depth z 0
- ⁇ b is the tissue backscattering coefficient
- ⁇ a is the tissue attenuation coefficient.
- the angular dependence ⁇ arises from varying beam delivering efficiency caused by catheter rotation and blood attenuation.
- the z dependence is caused by factors such as the divergent beam focusing profile.
- the tissue back-scattering coefficients and the attenuation coefficients are characteristic of tissue types and are the principal optical parameters used in certain embodiments to determine the tissue characteristics.
- the K value and A(z, ⁇ ) value are constant.
- the T(z 0 ) is also a constant.
- a linear relationship between log [P(z)] and the depth z is a reasonable assumption. Accordingly, a line can be fit to the data describing the relationship between scan depth and the signal received by the OCT system.
- This linear model has various uses. For example, based on this linear model, the attenuation coefficient can be calculated from the slope of the fitted line; while the backscattering coefficient can be calculated from the offset of the fitted line.
- the z dependence is illustrated by FIGS. 3A and 3B as discussed below.
- the z-dependence can be resolved using a model fit to the data shown in FIG. 3C .
- the ⁇ dependence has many influencing factors that can be addressed using certain techniques.
- the ⁇ dependence is resolved using a model fit to the data of FIG. 4B as described below.
- the OCT imaging machine and sample arm beam delivery device has various optical efficiencies. To ensure the accurate measurement of tissue optical properties, in addition to noise subtraction and filtering, the imaging system must be carefully calibrated and various artifacts must be removed. As shown in FIG. 2 , to calibrate the light intensity exiting the sample probe, one embodiment of this calibration method places a semi-transparent layer of materials 30 , having a known backscattering coefficient, around the optical probe 32 . In the figure shown, both are disposed in a lumen of interest 34 .
- the OCT intensity from this layer 30 is proportional to light intensity exiting the probe, thereby providing a calibrated optical reference.
- This semi-transparent layer 30 can be in the form of outer sheath of the catheter, a layer between the outmost sheath and the optical fiber probe, or a specific semi-transparent coating on the optical fiber, the catheter sheath or other structural layers in between that has calibrated reflection coefficients. In order to consider this embodiment in more detail, it is useful to review the components of an exemplary OCT probe.
- the OCT probe is composed of the rotating optical fiber 32 surrounded by one or more layers of plastic or glass. These constitute a substantially stationary protective sheath.
- the partial reflector can be either layer 30 (which is a part of the sheath), or an interface inside the optical fiber or GRIN lens assembly.
- the advantage of using layer 30 is that the intensity of layer 30 is generally visible in the OCT images.
- the disadvantage of layer 30 is that it is a larger and more complex structure. This greater size and complexity may be non-uniform and the overall layer may have a rotational dependence.
- One advantage of using the interface as the reflector is that it rotates together with the fiber. Hence, it does not suffer potential rotational dependence.
- the disadvantage of the interface is that it may lie outside the normal OCT scan range (i.e. proximal to the fiber tip, where the normal OCT image range begins just distal to the fiber tip) requiring the OCT scan range to adjusted inward to capture this interface and losing a commensurate portion of the outer scan region.
- the partial reflector 30 is used to calibrate the delivered incident light intensity (K). Partial reflecting layer 30 can be calibrated by injecting a laser of known intensity and recording the reflected signal strength.
- FIG. 3A An electromagnetic beam such as an opti c al beam suitable for performing OCT scans is shown in FIG. 3A , where w 0 is the beam waist and z 0 is the Rayleigh range. Due to finite wavelength, the optical beam used in the imaging is a Gaussian beam which is divergent from the beam waist. It produces a beam focusing profile that can be described by the Lorentzian function.
- A(z) is light intensity at depth z
- z o is the Rayleigh range
- f is the focal length of the lens assembly.
- the divergent beam profile produces an OCT intensity pattern that peaks at the focal plane, and rolls off from either side, as shown in FIG. 3B .
- the focal length of the imaging probe is measured and the inverse of equation (1.2) is applied to OCT signal P(z).
- the amplification factor is limited far from the focusing point as shown in FIG. 3C .
- a probe 50 suitable for collecting OCT data is shown in the cross-section.
- the light beam travels through many catheter sheath layers and liquid layers (such as saline or flushing agent) before arriving at the vessel walls. These layers may introduce a certain amount of attenuation that cannot be well predicted. If the light impinges onto the tissue at an oblique angle, part of its intensity may be lost in the surface reflection.
- a lumen boundary 53 is shown relative to a superficial layer 55 .
- the superficial layer 55 includes tissue a few coherence lengths away from the lumen boundary in the depth dimension is segmented.
- the region between the lumen boundary (the inner solid line) and the dotted line is the “superficial layer”.
- ⁇ is the rotational angle of the probe.
- the superficial layer 55 and other biological samples are composed of a homogeneous layer of fibrous tissue beneath the lumen boundary, it is reasonable to use the superficial layer 55 as a calibration basis for the ⁇ dependence in A(z, ⁇ ).
- the boundary 53 between the lumen and the vessel is found either by manual selection or by an automatic program.
- the OCT intensity in the region is then averaged over the depth to give the angular-dependent intensity profile shown in FIG. 4B .
- FIG. 4B shows the angular-dependent intensity profile as a function of ⁇ obtained from the superficial layer.
- the inverse of this profile shown in FIG. 4B is applied to OCT signal.
- the application of the inverse profile corrects the rotation-dependent intensity variation and non-uniform blood attenuation in the lumen.
- applying such an inverse profile to an OCT image would yield the image shown in FIG. 4A .
- various profiles and models are used to improve OCT image quality as described herein.
- Another problem with tissue characterization arises due to unwanted noise which makes it more challenging to distinguish tissue boundaries and distinguish other regions of interest.
- OCT image noise has several components: shot noise, laser noise and electrical noise. OCT images are also degraded by speckles. The speckle effect is inherent to coherent imaging and can reduce the accuracy of measurements of optical properties. To maintain high-resolution accuracy, denoising procedures that remove noise without degrading spatial resolution are performed.
- FIG. 5A shows a “before” image while FIG. 5B shows an improved “after” image following the application of the denoising procedures. Suitable denoising techniques and algorithms are known to those skilled in the art.
- a window W of image data of an appropriate size is taken.
- This window can be moved as shown in FIG. 6A to select different regions of interest over time (see FIG. 6B , ROI A ).
- the window W can be resized.
- a window refers to a one, two, or three-dimensional point, region, or volume of a specified size.
- This window W is sized such that the enclosed region offers sufficient amount of data for reliable model-fittings while maintaining sufficient spatial resolution.
- the axial lines (points, planes, or other elements) in the window W are averaged to produce a depth profile (or other profile) for that window.
- Model fitting is applied to the depth profile to obtain optical properties corresponding to that data window. For example, if a single-scattering model is employed, the depth profile is scaled as logarithmic as shown in FIG. 6C to facilitate a linear model fit. Then a line fitting is applied to the profile. Based on Equation (1.1) the offset of the line fitting offers a measurement of the backscatter coefficient, while the slope offers a measurement of the attenuation coefficient.
- region of interest (such as ROI A for example) are drawn either by a human operator or by a processor-based computer program or other software module.
- An exemplary region of interest ROI A is shown in FIG. 6B .
- OCT data inside a region of interest, such as that shown in FIG. 6B is averaged to produce a depth profile.
- the optical properties for the regions of interest are obtained by model fitting such as the linear data fitting shown in FIG. 6C .
- the wall of certain lumens, such as an artery, is a layered structure that includes different tissue components.
- the linear model fitting shown in FIG. 6C is only accurate for a single lumen layer.
- the lumen surface and the extent of the OCT penetration limit are first found by processing the OCT image or optical properties obtained from the OCT image. In one embodiment, this is performed by an automated computer program.
- the outer boundary B OCT shows the penetration limit of the OCT system.
- the inner boundary of the lumen is show by the inner boundary B Lum .
- a cross-section of the imaging probe P cs is also shown. As shown, the visibility of the outer boundary B OCT has been enhanced by the automated computer program.
- the tissue boundary detection is obtained by analyzing a single depth scan.
- An example of such boundary detection can be understood using the illustrative OCT data plot and linear curve fitting model in FIG. 8 .
- the depth profile is fitted with piece-wise model.
- different linear portions P 1 -P 3
- the discontinuities or break-points denote the tissue boundaries, while each line segment denotes one tissue type.
- P 1 represents or corresponds to the fiber tissue
- P 2 represents or corresponds to calcification tissue
- P 3 represents or corresponds to lipid tissue.
- the discontinuity between P 1 and P 2 shows a tissue boundary between the fiber tissue and the calcification tissue.
- tissue boundary detection is obtained by analyzing 2D or 3D OCT images, either by a human operator or an automatic algorithm.
- An example of such boundary detection is illustrated in FIG. 9 .
- a two-dimensional OCT image of a lumen is shown.
- the lumen L and calcification C boundaries are detected with automatic edge-detection methods, e.g., edge detection algorithm.
- tissue boundary detection is complete, corrected optical properties are retrieved by computational models.
- One example of such a model compensates for backscattering by the amount of cumulative attenuation due to any layers between the region being scanned and the imaging catheter.
- the tissue region Y is segmented by methods outlined above, which has different optical properties from the surrounding tissue region X.
- the intensity profile of S 1 and S 2 are shown in FIGS. 10B and 10C , respectively.
- the slope S x, i and S Y, i of the intensity profile S 1 and S 2 are calculated in their respective regions, where subscript i denotes the different scan lines.
- the attenuation coefficients of tissue X and Y are then calculated as the average of the slopes of all scan lines.
- the backscattering coefficient of tissue X is calculated as the offset of the intensity profile between A i and B i .
- the backscattering coefficients of tissue Y can not be calculated simply by the offset of the intensity profile between B i and C i .
- Another approach is used. Specifically, the effect on the offset by the attenuation due to the tissue X on top of tissue Y can be compensated using the following equation:
- the O y,i is the offset of the line fitting of tissue Y
- S x,i is calculated from the line fitting of tissue X
- d i is the thickness of tissue X.
- the O′ y,i and O y,i are the compensated and the original offset of the line fitting at tissue Y, respectively.
- S x,i is the slope of the line fitting at tissue X and d i is the depth spanned by scan line inside tissue X.
- the backscattering coefficients of tissue X and Y are then calculated as the average of the compensated offsets of all scan lines, Although in the above example the hypothetical image has only two tissue layers, the method can be extended to multiple-layers OCT image by compensating the offsets of bottom layer iteratively from the top.
- Another embodiment of this invention relates to the extraction of image features associated with specific tissue types based on 2D or 3D images. These features are not extracted solely from a depth-dependent scanning line, but rather rely on analysis of the patterns of neighboring scans.
- One example is differentiating calcium tissue and lipid tissue. In OCT, both tissue types appear to be signal poor while the surrounding fibrous or ground tissues appear to be signal rich. However, the boundary between calcium tissue and fibrous tissue is usually sharp, while the boundary between lipid tissue and fibrous tissue in OCT usually appears diffusive. The boundary sharpness can be quantified by measuring the derivative of the image brightness (edge acutance). Other quantifiable local image features include texture and shape information.
- One semi-automatic method for measuring boundary sharpness requires the operator to roughly preselect an edge line or a small area enclosing the edge line.
- Edge detection algorithms such as Canny's edge detector or region-growing methods
- the gray-level variance across the edge line yields a measure of the edge acutance.
- the edge acutance value is calculated by quantifying the inside-to-outside differences between the signals of the plaque and the surrounding tissue.
- texture usually refers to patterns of local variations in brightness.
- texture is closely related to the speckle formation, which is influenced by the density and size distribution of scattering elements or structures.
- vessel imaging under similar focusing conditions, the texture is observed to be correlated to tissue type. For example, large and densely packed macrophage foam cells form large speckles and exhibit a “solid” texture; while loosely packed proteoglycan molecules with smaller scattering elements form small speckles and exhibit a “gel” texture.
- intensity statistics e.g., intensity statistics, local pattern analysis (e.g., spatial gray-level co-occurrence matrices), or spectral analysis.
- the foam cells usually form ribbon-like features on the shoulders of large lipid pool.
- the media appears like annulus around the vessel, etc.
- shape information is currently used in qualitative assessment of OCT images. In computerized shape analysis, compactness, Fourier descriptors, central invariant moment, and chord-length distributions are the most commonly used methods. It should be appreciated that shape information can be either 2D shape, 3D shape or both.
- optical backscattering coefficient, optical attenuation coefficient, image edge sharpness, image texture, image shape are described in detail above as tissue parameters, the present invention is not limited to these parameters. Thus, other parameters (such as optical anisotropic factor) are within the scope of this invention. It should also be appreciated that while models and calculation methods to derive the parameters described above are possible methods, there are other physical models or calculation methods that are within the scope of this invention.
- a quantitative measurement of optical tissue and image properties can be displayed to an OCT operator to assist in clinical interpretation.
- the tissue properties are displayed individually.
- multiple tissue properties are displayed together using a combination display method.
- FIG. 11A there are two tissue cross-sections shown in FIG. 11A .
- the attenuation coefficients and backscattering coefficients are shown individually using a grayscale mapping.
- FIG. 11B shows a combination display method where the color map is devised to combine the backscattering and attenuation measurements.
- Letter “C”, “F”, and “L” denote the positions of average backscattering and attenuation coefficients for calcification, fibrous and lipid tissue, respectively.
- FIG. 11C shows the images combining backscattering and attenuation measurements in FIG. 11A using the color-map defined in FIG. 11B . Because the figures are published in black-and-white, FIG. 11D and FIG. 11E are shown by replacing the color-map in Fig. B and C with hatched texture maps. Improved contrast enhancement can be obtained using this approach to visualize plaques. It should be noted that instead of texture map, color-map or symbol encoded map using true colors or symbols can also be used and often generates improved visualizations.
- the characterization software analyzes the OCT data and measured tissue optical properties to generate image segmentations, define tissue boundaries, and identify tissue elements in samples of interest.
- the tissue parameters are calculated for each tissue sample or element thereof and compared to the parameters stored in a database. Based on these results, the tissue type or characterization is assigned to the tissue sample of element thereof according to univariate or multivariate discriminant analysis or classification.
- the calculated tissue parameters are displayed as numbers or color-coded images (e.g., discrete colors, grayscale, etc.).
- the derived tissue types are displayed to the user as texts or color-coded images (e.g., discrete colors, grayscale, etc.).
- FIGS. 12A and 12B Another method of generating and analyzing quantitative measurement of tissue optical and image properties is shown in FIGS. 12A and 12B .
- the first phase is an analysis and database populating phase and the second phase is a tissue characterization phase for a patient. These phases can be performed using the database and software shown in FIG. 1 .
- the vessel samples are excised and prepared (step 101 ) and OCT data is collected from a portion of the vessel.
- the histology data (step 103 ) and OCT data (step 104 ) are collected in parallel as shown.
- the OCT data is calibrated and the artifacts removed to generate consistent measurement.
- data-preprocessing steps step 108 ) are performed.
- the data-preprocessing steps can include, but are not limited to calibrating the system power, correcting a focusing effect, correcting angular dependence, and de-noising steps described in text above and in FIGS. 2 , 3 , 4 , 5 .
- the interrogated portion of the vessel is sectioned and processed by standard histology processing. Regions of interest encompassing specific tissue type (or vessel characterization) are identified by operator or a machine using certain criteria (Step 112 ). The regions of interest are mapped (step 114 ) to the OCT image data or processor-generated OCT image. Optical properties and spatial feature extraction (step 118 ) can also be performed. Finally, any resolved tissue properties can be stored (step 122 ) in a database for future analysis.
- FIG. 12B shows a method of identifying tissue type in situ.
- This method includes the step of collecting OCT data (step 126 ). Once collected, this OCT data is used to generate an OCT image (step 130 ) with respect to the scanned lumen or other sample of interest. In one embodiment, the OCT image is then subjected to the data-preprocessing steps (step 134 ). Optical properties and spatial feature extraction (step 138 ) can then be performed as outlined above. Tissue type identifiers or signatures are generated (step 142 ) as discussed above. Next, any suitable tissue type identifiers or signatures are stored (step 146 ) in the relevant database. At this point, various types of statistical analysis (step 150 ) as described herein can be performed to identify a particular tissue type in the OCT image using the stored tissue type identifiers or signatures.
- tissue types are identified and mapped on the histology images. These tissue identifiers or signatures that are stored can be used in the future to automatically identify tissue elements and types of interest for new OCT scans.
- the corresponding regions are also identified in the OCT data or image.
- An example of such mapped histology images is shown in FIG. 13A where tissue types (e.g., fibers (“F”), calcification (“Ca”), etc) were identified.
- the corresponding mapped OCT image is shown in 13 B.
- At least one optical property and other image features are extracted and stored in a tissue property database. The above-described process is repeated for each tissue types and each characterization as many times as desired to increase the accuracy of the quantitative measurement of parameters.
- FIG. 14 An example of suitable data for use in the database is shown in FIG. 14 , where the attenuation and backscattering coefficients for three tissue types are plotted. As shown in the plot, the calcification, fiber and lipid tissue forms clusters that are distinguishable by their positions in attenuation/backscatter space, which is the basis for the tissue characterization.
- the tissue characterization phase the vessel to be interrogated is imaged with OCT. The image is calibrated and the artifacts are removed. Then regions of interest are generated either by operator input or by automatic segmentation algorithm. The optical properties and other image features are extracted from the regions of interest. The quantitative measurements are compared to the tissue property database generated in the first phase.
- the discriminant analysis method (or classification analysis method) is used to identify tissue types based on the tissue properties. For example, different tissue types have different the optical backscattering ⁇ b and the attenuation coefficient ⁇ a . For any ROI to be examined, both parameters are measured. Hence, during the database population phase, the ( ⁇ b , ⁇ a ) pairs of different tissue types are obtained.
- the ( ⁇ b , ⁇ a ) pair of the tissue ROI is obtained, and the Mahalanobis distance is calculated between those of new acquired ROI and those values from the database. From the calculation, a decision is made to find the best match. For example, as shown in FIG. 15A , the distance is shortest between the ROI to the fibers in the database, and the ROI is characterized as fibrous tissue with a certain amount of confidence.
- the characterization results can be displayed as color-coded image or displayed using text legends describing the possible tissue characterization.
- FIG. 15B is an example of such characterization, where the overall gray dotted region represents the fibrous region, while the bottom “-” dotted region represents the lipid region.
- tissue regions and the associated coded legends include but are not limited to a fiber, lipid pool, fibrofatty, calcium nodule, calcium plate, calcium speckled, thrombus, foam cells, proteoglycan, and others.
- FIG. 15B and FIG. 11C are related, but different. In FIG. 15B the tissue types are pre-classified for the clinicians, while in FIG. 11C , a contrast-enhanced image is displayed, but the decision of tissue type is made by clinicians when interpreting the image.
- the optical properties and image features for such discriminant or classification analysis are not limited to backscattering coefficients and attenuation coefficients, but include, although not limited to edge sharpness, texture parameters, plaque geometrical shape etc.
- the algorithms for performing such analysis are not limited to Mahalanobis distance analysis, but include a variety of statistical methods.
- Biological tissues are complex. There are many tissue types and sub-types that possibly could not be distinguished by only combining the backscattering and attenuation measurements. For example, the foam cell tissue, and the lipid both have high backscattering and attenuation. Calcification and certain loose connective tissue both have low backscattering and low attenuation.
- FIG. 16A is a plot summarizing the backscattering vs. attenuation plot shown in FIG. 14 .
- the lipid tissue and foam cell tissue also have similar properties. Therefore, a discriminant method based on this plot alone is not sufficient to distinguish these tissue types with high accuracy.
- FIG. 16B shows a plot of edge sharpness measured for the boundary formed by the calcification tissue and fibrous tissue, and the boundary formed by the calcification tissue and lipid tissue. Significant difference was found for the edge transition width between these two types of boundaries. Hence, FIG. 16B could be used to further refine the tissue classification.
- foam cells are also an important indicator of disease state.
- the foam cells are usually enlarged macrophage or smooth muscle cells that are filled with lipid droplets. Because of the presence of these lipid droplets, it is often difficult to distinguish them from some lipid tissues. However, because foam cells are large cells and are often clustered into groups of various size, they tend have different texture appearance from lipid tissues, which are usually composed of extracellular lipid.
- FIG. 16C shows a texture parameter, gray-level co-occurrence matrix for lipid and macrophage tissue.
- the gray-level co-occurrence matrix calculation is available in many standard commercial image processing software, such as Matlab (MathWorks, Natick, Mass.). Although there are still some overlap between the lipid and foam cells in terms of texture measurements, the additional information helps to improve tissue characterization accuracy.
- the above analysis is to analyze edge sharpness and texture measurements after analyzing backscattering and attenuation. In other embodiments all of the analysis and comparison can be performed in parallel or in a combination serial/parallel steps.
- the data and decision shown in FIG. 16 is an example and additional parameters and threshold can be used with an OCT system trained using histology data as discussed above to identify any suitable tissue of interest.
- the present invention may be embodied in may different forms, including, but in no way limited to, computer program logic for use with a processor (e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer), programmable logic for use with a programmable logic device, (e.g., a Field Programmable Gate Array (FPGA) or other PLD), discrete components, integrated circuitry (e.g., an Application Specific Integrated Circuit (ASIC)), or any other means including any combination thereof.
- a processor e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer
- programmable logic for use with a programmable logic device, (e.g., a Field Programmable Gate Array (FPGA) or other PLD), discrete components, integrated circuitry (e.g., an Application Specific Integrated Circuit (ASIC)), or any other means including any combination thereof.
- FPGA Field Programmable Gate Array
- ASIC Application Specific Integrated Circuit
- some or all of the processing of the data collected using an OCT probe and the processor-based system is implemented as a set of computer program instructions that is converted into a computer executable form, stored as such in a computer readable medium, and executed by a microprocessor under the control of an operating system.
- query response and input data are transformed into processor understandable instructions suitable for generating OCT data, histology images, OCT images, ROIs, overlays, signal processing, artifact removal, and other features and embodiments described above.
- Source code may include a series of computer program instructions implemented in any of various programming languages (e.g., an object code, an assembly language, or a high-level language such as Fortran, C, C++, JAVA, or HTML) for use with various operating systems or operating environments.
- the source code may define and use various data structures and communication messages.
- the source code may be in a computer executable form (e.g., via an interpreter), or the source code may be converted (e.g., via a translator, assembler, or compiler) into a computer executable form.
- the computer program may be fixed in any form (e.g., source code form, computer executable form, or an intermediate form) either permanently or transitorily in a tangible storage medium, such as a semiconductor memory device (e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM), a magnetic memory device (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), a PC card (e.g., PCMCIA card), or other memory device.
- a semiconductor memory device e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM
- a magnetic memory device e.g., a diskette or fixed disk
- an optical memory device e.g., a CD-ROM
- PC card e.g., PCMCIA card
- the computer program may be fixed in any form in a signal that is transmittable to a computer using any of various communication technologies, including, but in no way limited to, analog technologies, digital technologies, optical technologies, wireless technologies (e.g., Bluetooth), networking technologies, and internetworking technologies.
- the computer program may be distributed in any form as a removable storage medium with accompanying printed or electronic documentation (e.g., shrink-wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the communication system (e.g., the Internet or World Wide Web).
- Hardware logic including programmable logic for use with a programmable logic device
- implementing all or part of the functionality previously described herein may be designed using traditional manual methods, or may be designed, captured, simulated, or documented electronically using various tools, such as Computer Aided Design (CAD), a hardware description language (e.g., VHDL or AHDL), or a PLD programming language (e.g., PALASM, ABEL, or CUPL).
- CAD Computer Aided Design
- a hardware description language e.g., VHDL or AHDL
- PLD programming language e.g., PALASM, ABEL, or CUPL
- Programmable logic may be fixed either permanently or transitorily in a tangible storage medium, such as a semiconductor memory device (e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM), a magnetic memory device (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), or other memory device.
- a semiconductor memory device e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM
- a magnetic memory device e.g., a diskette or fixed disk
- an optical memory device e.g., a CD-ROM
- the programmable logic may be fixed in a signal that is transmittable to a computer using any of various communication technologies, including, but in no way limited to, analog technologies, digital technologies, optical technologies, wireless technologies (e.g., Bluetooth), networking technologies, and internetworking technologies.
- the programmable logic may be distributed as a removable storage medium with accompanying printed or electronic documentation (e.g., shrink-wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the communication system (e.g., the Internet or World Wide Web).
- printed or electronic documentation e.g., shrink-wrapped software
- a computer system e.g., on system ROM or fixed disk
- server or electronic bulletin board e.g., the Internet or World Wide Web
- a module refers to software, hardware, or firmware suitable for performing a specific data processing or data transmission task.
- a module refers to a software routine, program, or other memory resident application suitable for receiving, transforming, routing and processing instructions, or various types of data such as OCT scan data, interferometer signal data, clock signals, region of interest types, formulas, and other information of interest.
- Computers and computer systems described herein may include operatively associated computer-readable media such as memory for storing software applications used in obtaining, processing, storing and/or communicating data. It can be appreciated that such memory can be internal, external, remote or local with respect to its operatively associated computer or computer system.
- Memory may also include any means for storing software or other instructions including, for example and without limitation, a hard disk, an optical disk, floppy disk, DVD (digital versatile disc), CD (compact disc), memory stick, flash memory, ROM (read only memory), RAM (random access memory), DRAM (dynamic random access memory), PROM (programmable ROM), EEPROM (extended erasable PROM), and/or other like computer-readable media.
- a hard disk an optical disk, floppy disk, DVD (digital versatile disc), CD (compact disc), memory stick, flash memory, ROM (read only memory), RAM (random access memory), DRAM (dynamic random access memory), PROM (programmable ROM), EEPROM (extended erasable PROM), and/or other like computer-readable media.
- computer-readable memory media applied in association with embodiments of the invention described herein may include any memory medium capable of storing instructions executed by a programmable apparatus. Where applicable, method steps described herein may be embodied or executed as instructions stored on a computer-readable memory medium or memory media. These instructions may be software embodied in various programming languages such as C++, C, Java, and/or a variety of other kinds of software programming languages that may be applied to create instructions in accordance with embodiments of the invention.
- a single component may be replaced by multiple components, and multiple components may be replaced by a single component, to provide an element or structure or to perform a given function or functions. Except where such substitution would not be operative to practice certain embodiments of the invention, such substitution is considered within the scope of the invention.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Endoscopes (AREA)
- Eye Examination Apparatus (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/455,523 US20090306520A1 (en) | 2008-06-02 | 2009-06-02 | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
US15/913,300 US11793462B2 (en) | 2008-06-02 | 2018-03-06 | Intravascular measurement and data collection systems, apparatus and methods |
US18/367,588 US20230414176A1 (en) | 2008-06-02 | 2023-09-13 | Intravascular Measurement And Data Collections Systems, Apparatus And Methods |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5807708P | 2008-06-02 | 2008-06-02 | |
US12/455,523 US20090306520A1 (en) | 2008-06-02 | 2009-06-02 | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/913,300 Continuation US11793462B2 (en) | 2008-06-02 | 2018-03-06 | Intravascular measurement and data collection systems, apparatus and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
US20090306520A1 true US20090306520A1 (en) | 2009-12-10 |
Family
ID=40933590
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/455,523 Abandoned US20090306520A1 (en) | 2008-06-02 | 2009-06-02 | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
US15/913,300 Active 2030-10-06 US11793462B2 (en) | 2008-06-02 | 2018-03-06 | Intravascular measurement and data collection systems, apparatus and methods |
US18/367,588 Pending US20230414176A1 (en) | 2008-06-02 | 2023-09-13 | Intravascular Measurement And Data Collections Systems, Apparatus And Methods |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/913,300 Active 2030-10-06 US11793462B2 (en) | 2008-06-02 | 2018-03-06 | Intravascular measurement and data collection systems, apparatus and methods |
US18/367,588 Pending US20230414176A1 (en) | 2008-06-02 | 2023-09-13 | Intravascular Measurement And Data Collections Systems, Apparatus And Methods |
Country Status (6)
Country | Link |
---|---|
US (3) | US20090306520A1 (zh) |
EP (1) | EP2293714B1 (zh) |
JP (3) | JP2011521747A (zh) |
CN (1) | CN102046071B (zh) |
ES (1) | ES2517915T3 (zh) |
WO (1) | WO2009149131A1 (zh) |
Cited By (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110071404A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US20110071405A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Apparatus, Systems, and Methods of in-vivo Blood Clearing in a Lumen |
WO2011072068A2 (en) | 2009-12-08 | 2011-06-16 | Avinger, Inc. | Devices and methods for predicting and preventing restenosis |
US20110151980A1 (en) * | 2009-12-22 | 2011-06-23 | Lightlab Imaging, Inc. | Torque limiter for an oct catheter |
US20110228280A1 (en) * | 2010-03-17 | 2011-09-22 | Lightlab Imaging, Inc. | Intensity Noise Reduction Methods and Apparatus for Interferometric Sensing and Imaging Systems |
US20110245683A1 (en) * | 2010-03-30 | 2011-10-06 | Terumo Kabushiki Kaisha | Optical imaging diagnostic apparatus and the display control method thereof |
US20110245684A1 (en) * | 2010-03-30 | 2011-10-06 | Terumo Kabushiki Kaisha | Optical imaging diagnostic apparatus and the display control method thereof |
US20120075638A1 (en) * | 2010-08-02 | 2012-03-29 | Case Western Reserve University | Segmentation and quantification for intravascular optical coherence tomography images |
US20120203117A1 (en) * | 2009-08-06 | 2012-08-09 | Agency For Science, Technology And Research | Vital signs detecting device and a method for detecting vital signs |
US20120213704A1 (en) * | 2009-06-18 | 2012-08-23 | Awdeh Richard M | System and method for molecular in vivo imaging and theranostics |
US8358461B2 (en) | 2008-09-03 | 2013-01-22 | Lightlab Imaging Inc. | Wavelength-tunable light source |
US20130044330A1 (en) * | 2011-08-15 | 2013-02-21 | The Johns Hopkins University | Optical coherence tomography system having real-time artifact and saturation correction |
US8449468B2 (en) | 2006-11-08 | 2013-05-28 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
WO2013106760A1 (en) * | 2012-01-12 | 2013-07-18 | The General Hospital Corporation | Systems, methods and computer-readable medium for determining depth-resolved physical and/or optical properties of scattering media by analyzing measured data over a range of depths |
US8526472B2 (en) | 2009-09-03 | 2013-09-03 | Axsun Technologies, Inc. | ASE swept source with self-tracking filter for OCT medical imaging |
US20130242313A1 (en) * | 2010-11-05 | 2013-09-19 | Peter Tomlins | Scanning methods and apparatus |
US8582619B2 (en) | 2011-03-15 | 2013-11-12 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US8582109B1 (en) | 2011-08-01 | 2013-11-12 | Lightlab Imaging, Inc. | Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography |
US8670129B2 (en) | 2009-09-03 | 2014-03-11 | Axsun Technologies, Inc. | Filtered ASE swept source for OCT medical imaging |
JP2014516646A (ja) * | 2011-04-29 | 2014-07-17 | ザ ジェネラル ホスピタル コーポレイション | 散乱媒質の深さ分解した物理的及び/又は光学的特性を決定する方法 |
US8831321B1 (en) | 2011-11-07 | 2014-09-09 | Lightlab Imaging, Inc. | Side branch detection methods, systems and devices |
US8926590B2 (en) | 2009-12-22 | 2015-01-06 | Lightlab Imaging, Inc. | Torque limiter for an OCT catheter |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US9007696B2 (en) | 2007-11-12 | 2015-04-14 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US9069396B2 (en) | 2013-03-12 | 2015-06-30 | Lightlab Imaging, Inc. | Controller and user interface device, systems, and methods |
US9125562B2 (en) | 2009-07-01 | 2015-09-08 | Avinger, Inc. | Catheter-based off-axis optical coherence tomography imaging system |
US9164240B2 (en) | 2011-03-31 | 2015-10-20 | Lightlab Imaging, Inc. | Optical buffering methods, apparatus, and systems for increasing the repetition rate of tunable light sources |
US9173591B2 (en) | 2013-03-08 | 2015-11-03 | Lightlab Imaging, Inc. | Stent visualization and malapposition detection systems, devices, and methods |
US9186066B2 (en) | 2006-02-01 | 2015-11-17 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
JP2016011935A (ja) * | 2014-06-30 | 2016-01-21 | 株式会社トプコン | 皮膚性状評価装置 |
JP2016508750A (ja) * | 2012-12-12 | 2016-03-24 | ライトラボ・イメージング・インコーポレーテッド | 血管の内腔輪郭の自動化された決定のための方法および装置 |
US9330092B2 (en) | 2011-07-19 | 2016-05-03 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
US9326682B2 (en) | 2005-04-28 | 2016-05-03 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US9341783B2 (en) | 2011-10-18 | 2016-05-17 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9345510B2 (en) | 2010-07-01 | 2016-05-24 | Avinger, Inc. | Atherectomy catheters with longitudinally displaceable drive shafts |
US9345406B2 (en) | 2011-11-11 | 2016-05-24 | Avinger, Inc. | Occlusion-crossing devices, atherectomy devices, and imaging |
US9345398B2 (en) | 2012-05-14 | 2016-05-24 | Avinger, Inc. | Atherectomy catheter drive assemblies |
US9351698B2 (en) | 2013-03-12 | 2016-05-31 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
EP2903533A4 (en) * | 2012-10-05 | 2016-06-22 | Elizabeth Begin | SYSTEMS FOR INDICATING PARAMETERS IN AN IMAGING DATA SET AND METHODS OF USE |
US9408539B2 (en) | 2010-03-05 | 2016-08-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US9415550B2 (en) | 2012-08-22 | 2016-08-16 | The General Hospital Corporation | System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography |
US9441948B2 (en) | 2005-08-09 | 2016-09-13 | The General Hospital Corporation | Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography |
US20160270766A1 (en) * | 2015-03-20 | 2016-09-22 | Terumo Kabushiki Kaisha | Diagnostic imaging apparatus, control method, program, and computer-readable storage medium |
CN105996999A (zh) * | 2016-05-19 | 2016-10-12 | 南京航空航天大学 | 基于oct测量样品深度分辨衰减系数的方法和系统 |
US9468379B2 (en) | 2010-04-21 | 2016-10-18 | Koninklijke Philips N.V. | Determination of a lipid water ratio |
US9498600B2 (en) | 2009-07-01 | 2016-11-22 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
US9498247B2 (en) | 2014-02-06 | 2016-11-22 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
US9516997B2 (en) | 2006-01-19 | 2016-12-13 | The General Hospital Corporation | Spectrally-encoded endoscopy techniques, apparatus and methods |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US9557156B2 (en) | 2012-05-14 | 2017-01-31 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
US9572492B2 (en) | 2008-04-23 | 2017-02-21 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US9592075B2 (en) | 2014-02-06 | 2017-03-14 | Avinger, Inc. | Atherectomy catheters devices having multi-channel bushings |
US9610064B2 (en) | 2011-05-31 | 2017-04-04 | Desmond Adler | Multimodal imaging system, apparatus, and methods |
US9615748B2 (en) | 2009-01-20 | 2017-04-11 | The General Hospital Corporation | Endoscopic biopsy apparatus, system and method |
US9629528B2 (en) | 2012-03-30 | 2017-04-25 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
US9642646B2 (en) | 2009-04-28 | 2017-05-09 | Avinger, Inc. | Guidewire positioning catheter |
USRE46412E1 (en) | 2006-02-24 | 2017-05-23 | The General Hospital Corporation | Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography |
US9664615B2 (en) | 2004-07-02 | 2017-05-30 | The General Hospital Corporation | Imaging system and related techniques |
US9677869B2 (en) | 2012-12-05 | 2017-06-13 | Perimeter Medical Imaging, Inc. | System and method for generating a wide-field OCT image of a portion of a sample |
US9702762B2 (en) | 2013-03-15 | 2017-07-11 | Lightlab Imaging, Inc. | Calibration and image processing devices, methods, and systems |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US9763623B2 (en) | 2004-08-24 | 2017-09-19 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
US9788790B2 (en) | 2009-05-28 | 2017-10-17 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US9833221B2 (en) | 2013-03-15 | 2017-12-05 | Lightlab Imaging, Inc. | Apparatus and method of image registration |
WO2017214421A1 (en) * | 2016-06-08 | 2017-12-14 | Research Development Foundation | Systems and methods for automated coronary plaque characterization and risk assessment using intravascular optical coherence tomography |
US9854979B2 (en) | 2013-03-15 | 2018-01-02 | Avinger, Inc. | Chronic total occlusion crossing devices with imaging |
US9892507B2 (en) | 2013-07-02 | 2018-02-13 | Michelson Diagnostics Ltd. | Processing optical coherence tomography scans of a subjects skin |
US9928590B2 (en) | 2012-04-23 | 2018-03-27 | Olympus Corporation | Image processing apparatus, image processing method, and computer-readable recording device for determining whether candidate region is abnormality or residue |
US9940723B2 (en) | 2014-12-12 | 2018-04-10 | Lightlab Imaging, Inc. | Systems and methods to detect and display endovascular features |
US9949754B2 (en) | 2011-03-28 | 2018-04-24 | Avinger, Inc. | Occlusion-crossing devices |
US9968245B2 (en) | 2006-10-19 | 2018-05-15 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
US10028725B2 (en) | 2013-03-11 | 2018-07-24 | Lightlab Imaging, Inc. | Friction torque limiter for an imaging catheter |
US10058250B2 (en) | 2013-07-26 | 2018-08-28 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
US10089755B2 (en) | 2015-07-25 | 2018-10-02 | Lightlab Imaging, Inc. | Guidewire detection systems, methods, and apparatuses |
US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
US10130386B2 (en) | 2013-07-08 | 2018-11-20 | Avinger, Inc. | Identification of elastic lamina to guide interventional therapy |
US10140712B2 (en) | 2015-05-17 | 2018-11-27 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
US10172582B2 (en) | 2015-11-18 | 2019-01-08 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10222956B2 (en) | 2015-05-17 | 2019-03-05 | Lightlab Imaging, Inc. | Intravascular imaging user interface systems and methods |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US10307070B2 (en) | 2014-04-04 | 2019-06-04 | St. Jude Medical Coordination Center Bvba | Intravascular pressure and flow data diagnostic systems, devices, and methods |
US10335173B2 (en) | 2012-09-06 | 2019-07-02 | Avinger, Inc. | Re-entry stylet for catheter |
US10338795B2 (en) * | 2015-07-25 | 2019-07-02 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US10357277B2 (en) | 2014-07-08 | 2019-07-23 | Avinger, Inc. | High speed chronic total occlusion crossing devices |
US10363062B2 (en) | 2011-10-17 | 2019-07-30 | Avinger, Inc. | Atherectomy catheters and non-contact actuation mechanism for catheters |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
US10453190B2 (en) | 2015-11-23 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of and validation of shadows in intravascular images |
US10453196B2 (en) | 2015-11-18 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
US10499813B2 (en) | 2014-09-12 | 2019-12-10 | Lightlab Imaging, Inc. | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
US10548478B2 (en) | 2010-07-01 | 2020-02-04 | Avinger, Inc. | Balloon atherectomy catheters with imaging |
US10568520B2 (en) | 2015-07-13 | 2020-02-25 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US10577573B2 (en) | 2017-07-18 | 2020-03-03 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
US10593037B2 (en) | 2016-04-14 | 2020-03-17 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
US10631718B2 (en) | 2015-08-31 | 2020-04-28 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US10631754B2 (en) | 2016-05-16 | 2020-04-28 | Lightlab Imaging, Inc. | Intravascular absorbable stent detection and diagnostic methods and systems |
US10646198B2 (en) | 2015-05-17 | 2020-05-12 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US10648918B2 (en) | 2011-08-03 | 2020-05-12 | Lightlab Imaging, Inc. | Systems, methods and apparatus for determining a fractional flow reserve (FFR) based on the minimum lumen area (MLA) and the constant |
US10722292B2 (en) | 2013-05-31 | 2020-07-28 | Covidien Lp | Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
US10792012B2 (en) | 2012-11-19 | 2020-10-06 | Lightlab Imaging, Inc. | Interface devices, systems and methods for multimodal probes |
US10835110B2 (en) | 2008-07-14 | 2020-11-17 | The General Hospital Corporation | Apparatus and method for facilitating at least partial overlap of dispersed ration on at least one sample |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
US10912462B2 (en) | 2014-07-25 | 2021-02-09 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
US10932670B2 (en) | 2013-03-15 | 2021-03-02 | Avinger, Inc. | Optical pressure sensor assembly |
US11058346B2 (en) | 2017-10-30 | 2021-07-13 | Wenzhou Medical University | Optical imaging method based on mapping of layered structure |
US11096717B2 (en) | 2013-03-15 | 2021-08-24 | Avinger, Inc. | Tissue collection device for catheter |
US11166668B2 (en) | 2014-07-24 | 2021-11-09 | Lightlab Imaging, Inc. | Pre and post stent planning along with vessel visualization and diagnostic systems, devices, and methods for automatically identifying stent expansion profile |
US11179028B2 (en) | 2013-02-01 | 2021-11-23 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
CN113876357A (zh) * | 2020-11-04 | 2022-01-04 | 科特有限责任公司 | 具有可滑动套管的成像及压力传感装置和探头 |
US11224459B2 (en) | 2016-06-30 | 2022-01-18 | Avinger, Inc. | Atherectomy catheter with shapeable distal tip |
US11234751B2 (en) | 2009-07-31 | 2022-02-01 | Case Western Reserve University | Characterizing ablation lesions using optical coherence tomography (OCT) |
US11278248B2 (en) | 2016-01-25 | 2022-03-22 | Avinger, Inc. | OCT imaging catheter with lag correction |
US11278206B2 (en) | 2015-04-16 | 2022-03-22 | Gentuity, Llc | Micro-optic probes for neurology |
US11284916B2 (en) | 2012-09-06 | 2022-03-29 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US11311200B1 (en) | 2014-08-27 | 2022-04-26 | Lightlab Imaging, Inc. | Systems and methods to measure physiological flow in coronary arteries |
WO2022087378A1 (en) * | 2020-10-23 | 2022-04-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Data acquisition and measurement of characteristic functionals in biology and medicine |
CN114489151A (zh) * | 2021-12-13 | 2022-05-13 | 中国地质科学院矿产资源研究所 | 一种激光器输出功率控制装置及其控制方法 |
US11331142B2 (en) | 2020-01-13 | 2022-05-17 | Medlumics S.L. | Methods, devices, and support structures for assembling optical fibers in catheter tips |
US11344373B2 (en) | 2018-05-29 | 2022-05-31 | Lightlab Imaging, Inc. | Stent expansion display, systems, and methods |
US11344327B2 (en) | 2016-06-03 | 2022-05-31 | Avinger, Inc. | Catheter device with detachable distal end |
US11350832B2 (en) | 2014-08-27 | 2022-06-07 | St. Jude Medical Coordination Center Bvba | Cardiac cycle-based diagnostic systems and methods |
US11357403B2 (en) | 2016-10-28 | 2022-06-14 | Fujifilm Corporation | Optical coherence tomography apparatus and measurement method |
US11357569B2 (en) | 2020-01-13 | 2022-06-14 | Medlumics S.L. | Optical-guided ablation system for use with pulsed fields or other energy sources |
US11382653B2 (en) | 2010-07-01 | 2022-07-12 | Avinger, Inc. | Atherectomy catheter |
CN114820605A (zh) * | 2022-06-28 | 2022-07-29 | 广州永士达医疗科技有限责任公司 | 一种咽鼓管oct图像识别处理方法及装置 |
US11399863B2 (en) | 2016-04-01 | 2022-08-02 | Avinger, Inc. | Atherectomy catheter with serrated cutter |
US11406412B2 (en) | 2012-05-14 | 2022-08-09 | Avinger, Inc. | Atherectomy catheters with imaging |
US11452433B2 (en) | 2013-07-19 | 2022-09-27 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US11464412B2 (en) | 2017-12-27 | 2022-10-11 | Medlumics S.L. | Bi-refringence compensated waveguides |
US11490826B2 (en) | 2009-07-14 | 2022-11-08 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
US11517199B2 (en) | 2014-08-08 | 2022-12-06 | Medlumics S.L. | Crossing coronary occlusions |
US11523740B2 (en) | 2020-01-13 | 2022-12-13 | Medlumics S.L. | Systems and methods for optical analysis and lesion prediction using ablation catheters |
US11684242B2 (en) | 2017-11-28 | 2023-06-27 | Gentuity, Llc | Imaging system |
WO2023183420A1 (en) * | 2022-03-22 | 2023-09-28 | Case Western Reserve University | Methods, systems and apparatuses for transseptal procedures |
US11779220B2 (en) | 2018-12-14 | 2023-10-10 | Research Development Foundation | Multi-channel orthogonal convolutional neural networks |
US11793400B2 (en) | 2019-10-18 | 2023-10-24 | Avinger, Inc. | Occlusion-crossing devices |
US11883107B2 (en) | 2016-09-28 | 2024-01-30 | Lightlab Imaging, Inc. | Stent planning systems and methods using vessel representation obtained via intravascular probe by determining stent effectiveness score and fractional flow reserve |
US11992329B2 (en) | 2019-06-19 | 2024-05-28 | Michelson Diagnostics Ltd. | Processing optical coherence tomography scans |
US11998311B2 (en) | 2021-07-26 | 2024-06-04 | Avinger, Inc. | Guidewire positioning catheter |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2517915T3 (es) | 2008-06-02 | 2014-11-04 | Lightlab Imaging, Inc. | Métodos cuantitativos para obtener características de un tejido a partir de imágenes de tomografía por coherencia óptica |
KR20130135660A (ko) * | 2012-06-01 | 2013-12-11 | 삼성전자주식회사 | 단층 영상 생성 장치 및 단층 영상 생성 방법 |
CN102783938A (zh) * | 2012-09-04 | 2012-11-21 | 上海师范大学 | 一种基于散斑对比度的oct图像分析方法 |
CN106030608A (zh) * | 2013-11-06 | 2016-10-12 | 理海大学 | 生物组织分析诊断系统与方法 |
JP2015104582A (ja) * | 2013-11-29 | 2015-06-08 | 株式会社ニデック | 光断層像撮影装置、及び光断層像撮影プログラム |
EP3289565B1 (en) * | 2015-04-29 | 2020-08-12 | AIBILI - Associacao para Investigacao Biomedica e Inovacao em Luz e Imagem | Method and device for the non-invasive indirect identification of sites of alterations of the blood-retinal barrier |
WO2017005838A1 (en) * | 2015-07-09 | 2017-01-12 | Agfa Healthcare | Non-invasive biological tissue examination based on full field high definition optical coherence tomography imaging |
CN108135472B (zh) * | 2015-11-26 | 2020-10-30 | 法玛科技顾问股份有限公司 | 光断层扫描数字印模取像系统及其使用方法 |
CN105825488B (zh) * | 2016-05-30 | 2018-08-21 | 天津大学 | 一种心血管内光学相干层析图像增强方法 |
CN106332713B (zh) * | 2016-08-16 | 2019-06-11 | 浙江科技学院 | 一种sd-oct图像的枇杷早期瘀伤鉴别方法 |
GB201702098D0 (en) * | 2017-02-08 | 2017-03-22 | Michelson Diagnostics Ltd | Processing optical coherence tomography (OCT) scans |
IL268853B1 (en) * | 2017-02-28 | 2024-04-01 | Photonicare Inc | A handheld image-based imaging system and methods for use |
CN106974622B (zh) * | 2017-04-06 | 2021-08-24 | 上海交通大学 | 基于光学相干断层成像的斑块稳定性测量系统 |
JP6989870B2 (ja) * | 2017-09-29 | 2022-01-12 | 株式会社 資生堂 | 皮膚の血管網を可視化する装置、方法およびプログラム |
WO2019071295A1 (en) | 2017-10-11 | 2019-04-18 | OncoRes Medical Pty Ltd | METHOD FOR VOLUMETRIC SAMPLE IMAGING |
US10517681B2 (en) | 2018-02-27 | 2019-12-31 | NavLab, Inc. | Artificial intelligence guidance system for robotic surgery |
CA3103538A1 (en) * | 2018-06-11 | 2019-12-19 | Socovar, Societe En Commandite | System and method for determining coronal artery tissue type based on an oct image and using trained engines |
CN111915564B (zh) * | 2020-07-02 | 2022-04-22 | 西安交通大学 | 联合机器视觉与oct技术的冷冻肉制品光学特性检测方法 |
CN112057044A (zh) * | 2020-08-25 | 2020-12-11 | 南京沃福曼医疗科技有限公司 | 一种oct图像反射和衰减系数提取方法 |
KR20240039440A (ko) * | 2022-09-19 | 2024-03-26 | 부산대학교 산학협력단 | 근적외선 광원을 이용한 동맥경화반 성분분석이 가능한 광단층 내시경 시스템 및 이의 제어 방법 |
Citations (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5054492A (en) * | 1990-12-17 | 1991-10-08 | Cardiovascular Imaging Systems, Inc. | Ultrasonic imaging catheter having rotational image correlation |
US5321501A (en) * | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US5465147A (en) * | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5488674A (en) * | 1992-05-15 | 1996-01-30 | David Sarnoff Research Center, Inc. | Method for fusing images and apparatus therefor |
US5509093A (en) * | 1993-10-13 | 1996-04-16 | Micron Optics, Inc. | Temperature compensated fiber fabry-perot filters |
US5531227A (en) * | 1994-01-28 | 1996-07-02 | Schneider Medical Technologies, Inc. | Imaging device and method |
US5662109A (en) * | 1990-12-14 | 1997-09-02 | Hutson; William H. | Method and system for multi-dimensional imaging and analysis for early detection of diseased tissue |
US5748598A (en) * | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US5771895A (en) * | 1996-02-12 | 1998-06-30 | Slager; Cornelis J. | Catheter for obtaining three-dimensional reconstruction of a vascular lumen and wall |
US5784352A (en) * | 1995-07-21 | 1998-07-21 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
US5797849A (en) * | 1995-03-28 | 1998-08-25 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US5920390A (en) * | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US5956355A (en) * | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US5989189A (en) * | 1997-10-24 | 1999-11-23 | Mentor Corporation | Ophthalmic ultrasound imaging |
US5999588A (en) * | 1998-04-17 | 1999-12-07 | Adac Laboratories | Deadtime correction in a nuclear medicine imaging system |
US6013033A (en) * | 1995-02-01 | 2000-01-11 | Centre National De La Recherche Scientifique | Intracavitary echographic imaging catheter |
US6111645A (en) * | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6134003A (en) * | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6148095A (en) * | 1997-09-08 | 2000-11-14 | University Of Iowa Research Foundation | Apparatus and method for determining three-dimensional representations of tortuous vessels |
US6191862B1 (en) * | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6208883B1 (en) * | 1995-07-26 | 2001-03-27 | Associates Of The Joint Center For Radiation Therapy, Inc. | Ultrasound localization and image fusion for the treatment of prostate cancer |
US20020115931A1 (en) * | 2001-02-21 | 2002-08-22 | Strauss H. William | Localizing intravascular lesions on anatomic images |
US6445939B1 (en) * | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US6485413B1 (en) * | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6501551B1 (en) * | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US20030028100A1 (en) * | 2001-05-01 | 2003-02-06 | Tearney Guillermo J. | Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties |
US6552796B2 (en) * | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US6570659B2 (en) * | 2001-03-16 | 2003-05-27 | Lightlab Imaging, Llc | Broadband light source system and method and light source combiner |
US6608717B1 (en) * | 1999-01-29 | 2003-08-19 | Colorado State University Research Foundation | Optical coherence microscope and methods of use for rapid in vivo three-dimensional visualization of biological function |
US20040215166A1 (en) * | 2003-04-25 | 2004-10-28 | Michael Atlas | Flush catheter with flow directing sheath |
US6879851B2 (en) * | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
US6891984B2 (en) * | 2002-07-25 | 2005-05-10 | Lightlab Imaging, Llc | Scanning miniature optical probes with optical distortion correction and rotational control |
US20050238067A1 (en) * | 2004-04-26 | 2005-10-27 | Choi Youngmin A | Simple fiber optic cavity |
US20060095065A1 (en) * | 2004-09-24 | 2006-05-04 | Tetsuaki Tanimura | Fluid occluding devices and methods |
US7061622B2 (en) * | 2001-08-03 | 2006-06-13 | Case Western Reserve University | Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography |
US20060165270A1 (en) * | 2003-02-25 | 2006-07-27 | Jorn Borgert | Intravascular imaging |
US20060187537A1 (en) * | 2005-01-20 | 2006-08-24 | Robert Huber | Mode locking methods and apparatus |
US20060203859A1 (en) * | 2005-01-24 | 2006-09-14 | Cable Alex E | Compact multimode laser with rapid wavelength scanning |
US20060241465A1 (en) * | 2005-01-11 | 2006-10-26 | Volcano Corporation | Vascular image co-registration |
US20060241461A1 (en) * | 2005-04-01 | 2006-10-26 | White Chris A | System and method for 3-D visualization of vascular structures using ultrasound |
US20060241503A1 (en) * | 2005-02-10 | 2006-10-26 | Lightlab Imaging, Inc. | Optical coherence tomography apparatus and methods |
US20060244973A1 (en) * | 2003-10-27 | 2006-11-02 | Seok-Hyun Yun | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US7148970B2 (en) * | 2001-10-16 | 2006-12-12 | The General Hospital Corporation | Systems and methods for imaging a sample |
US20070081236A1 (en) * | 2005-09-29 | 2007-04-12 | The General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US7208333B2 (en) * | 2001-03-12 | 2007-04-24 | Axsun Technologies, Inc. | Process for fabricating MEMS membrane with integral mirror/lens |
US20070115481A1 (en) * | 2005-11-18 | 2007-05-24 | Duke University | Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
US20070123771A1 (en) * | 2005-11-04 | 2007-05-31 | Thomas Redel | Three-dimensional co-registration between intravascular and angiographic data |
US20080100612A1 (en) * | 2006-10-27 | 2008-05-01 | Dastmalchi Shahram S | User interface for efficiently displaying relevant oct imaging data |
US20080161696A1 (en) * | 2006-11-08 | 2008-07-03 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US20080165366A1 (en) * | 2007-01-10 | 2008-07-10 | Lightlab Imaging, Inc. | Methods and apparatus for swept-source optical coherence tomography |
US20080177183A1 (en) * | 2007-01-19 | 2008-07-24 | Brian Courtney | Imaging probe with combined ultrasounds and optical means of imaging |
US7415049B2 (en) * | 2005-03-28 | 2008-08-19 | Axsun Technologies, Inc. | Laser with tilted multi spatial mode resonator tuning element |
US20090079993A1 (en) * | 2005-11-22 | 2009-03-26 | Shofu Inc. | Dental Optical Coherence Tomograph |
US7787129B2 (en) * | 2006-01-31 | 2010-08-31 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
US8983580B2 (en) * | 2008-01-18 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3162070B2 (ja) | 1990-11-22 | 2001-04-25 | オリンパス光学工業株式会社 | 被検体内部情報観察装置 |
JPH0970404A (ja) | 1995-09-07 | 1997-03-18 | Akira Itabashi | 骨組織解析装置および方法 |
JP3771364B2 (ja) * | 1997-12-12 | 2006-04-26 | 浜松ホトニクス株式会社 | 光ct装置及び画像再構成方法 |
US6228076B1 (en) | 1999-01-09 | 2001-05-08 | Intraluminal Therapeutics, Inc. | System and method for controlling tissue ablation |
US6706004B2 (en) | 2001-05-31 | 2004-03-16 | Infraredx, Inc. | Balloon catheter |
US7072047B2 (en) * | 2002-07-12 | 2006-07-04 | Case Western Reserve University | Method and system for quantitative image correction for optical coherence tomography |
US7074188B2 (en) * | 2002-08-26 | 2006-07-11 | The Cleveland Clinic Foundation | System and method of characterizing vascular tissue |
EP2319404B1 (en) | 2003-01-24 | 2015-03-11 | The General Hospital Corporation | System and method for identifying tissue low-coherence interferometry |
JP4790231B2 (ja) | 2004-06-17 | 2011-10-12 | 花王株式会社 | 表皮の解析方法 |
JP5324095B2 (ja) | 2004-08-24 | 2013-10-23 | ザ ジェネラル ホスピタル コーポレイション | 血管セグメントを画像化する方法および装置 |
DK2062553T3 (da) | 2005-04-05 | 2010-11-29 | Alcon Inc | Optimale IOL-formfaktorer for oftalmiske linser |
WO2007002685A2 (en) | 2005-06-24 | 2007-01-04 | Volcano Corporation | Co-registration of graphical image data representing three-dimensional vascular features |
JP4691657B2 (ja) | 2005-07-28 | 2011-06-01 | 国立大学法人山口大学 | 柔軟な光ファイバーを関節内に挿入可能な関節内軟骨評価プローブ及び関節内軟骨評価装置 |
GB0515758D0 (en) * | 2005-07-30 | 2005-09-07 | Univ Hospital Of North Staffor | Improvements in and relating to optical coherence tomography |
US7668342B2 (en) * | 2005-09-09 | 2010-02-23 | Carl Zeiss Meditec, Inc. | Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues |
US7801343B2 (en) * | 2005-11-29 | 2010-09-21 | Siemens Medical Solutions Usa, Inc. | Method and apparatus for inner wall extraction and stent strut detection using intravascular optical coherence tomography imaging |
US20080058593A1 (en) | 2006-08-21 | 2008-03-06 | Sti Medical Systems, Llc | Computer aided diagnosis using video from endoscopes |
JP2008069107A (ja) | 2006-09-14 | 2008-03-27 | Pentax Corp | 内視鏡用組織蛍光染色剤 |
ES2517915T3 (es) | 2008-06-02 | 2014-11-04 | Lightlab Imaging, Inc. | Métodos cuantitativos para obtener características de un tejido a partir de imágenes de tomografía por coherencia óptica |
JP5778579B2 (ja) | 2008-10-14 | 2015-09-16 | ライトラボ・イメージング・インコーポレーテッド | 光コヒーレンス断層撮影法を使用するステントストラット検出ならびに関連する測定および表示のための方法 |
JP5579464B2 (ja) | 2010-02-24 | 2014-08-27 | 株式会社クラレ | ポリビニルアルコール系重合体フィルム用接着剤 |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US10596041B2 (en) | 2014-08-28 | 2020-03-24 | Ascension Texas | Apparatuses and methods for minimizing wound dehiscence, scar spread, and/or the like |
CN106377229B (zh) | 2016-10-18 | 2019-04-09 | 全景恒升(北京)科学技术有限公司 | 一种旋转式声学和光学合并成像系统 |
CN106361295A (zh) | 2016-12-06 | 2017-02-01 | 全景恒升(北京)科学技术有限公司 | 一种光学和声学混合成像导管 |
CN107730540B (zh) | 2017-10-09 | 2020-11-17 | 全景恒升(北京)科学技术有限公司 | 基于高精度匹配模型的冠脉参数的计算方法 |
-
2009
- 2009-06-02 ES ES09759290.1T patent/ES2517915T3/es active Active
- 2009-06-02 CN CN2009801192241A patent/CN102046071B/zh active Active
- 2009-06-02 JP JP2011511907A patent/JP2011521747A/ja active Pending
- 2009-06-02 WO PCT/US2009/046035 patent/WO2009149131A1/en active Application Filing
- 2009-06-02 EP EP09759290.1A patent/EP2293714B1/en active Active
- 2009-06-02 US US12/455,523 patent/US20090306520A1/en not_active Abandoned
-
2014
- 2014-01-24 JP JP2014011005A patent/JP2014097417A/ja active Pending
-
2015
- 2015-06-02 JP JP2015112641A patent/JP2015231526A/ja active Pending
-
2018
- 2018-03-06 US US15/913,300 patent/US11793462B2/en active Active
-
2023
- 2023-09-13 US US18/367,588 patent/US20230414176A1/en active Pending
Patent Citations (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5662109A (en) * | 1990-12-14 | 1997-09-02 | Hutson; William H. | Method and system for multi-dimensional imaging and analysis for early detection of diseased tissue |
US5054492A (en) * | 1990-12-17 | 1991-10-08 | Cardiovascular Imaging Systems, Inc. | Ultrasonic imaging catheter having rotational image correlation |
US6134003A (en) * | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6282011B1 (en) * | 1991-04-29 | 2001-08-28 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6485413B1 (en) * | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6501551B1 (en) * | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US5459570A (en) * | 1991-04-29 | 1995-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements |
US5321501A (en) * | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US6421164B2 (en) * | 1991-04-29 | 2002-07-16 | Massachusetts Institute Of Technology | Interferometeric imaging with a grating based phase control optical delay line |
US5465147A (en) * | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US6160826A (en) * | 1991-04-29 | 2000-12-12 | Massachusetts Institute Of Technology | Method and apparatus for performing optical frequency domain reflectometry |
US6111645A (en) * | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US5956355A (en) * | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US5488674A (en) * | 1992-05-15 | 1996-01-30 | David Sarnoff Research Center, Inc. | Method for fusing images and apparatus therefor |
US5509093A (en) * | 1993-10-13 | 1996-04-16 | Micron Optics, Inc. | Temperature compensated fiber fabry-perot filters |
US5531227A (en) * | 1994-01-28 | 1996-07-02 | Schneider Medical Technologies, Inc. | Imaging device and method |
US6013033A (en) * | 1995-02-01 | 2000-01-11 | Centre National De La Recherche Scientifique | Intracavitary echographic imaging catheter |
US5797849A (en) * | 1995-03-28 | 1998-08-25 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US5784352A (en) * | 1995-07-21 | 1998-07-21 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
US6208883B1 (en) * | 1995-07-26 | 2001-03-27 | Associates Of The Joint Center For Radiation Therapy, Inc. | Ultrasound localization and image fusion for the treatment of prostate cancer |
US5748598A (en) * | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US5771895A (en) * | 1996-02-12 | 1998-06-30 | Slager; Cornelis J. | Catheter for obtaining three-dimensional reconstruction of a vascular lumen and wall |
US5920390A (en) * | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US6148095A (en) * | 1997-09-08 | 2000-11-14 | University Of Iowa Research Foundation | Apparatus and method for determining three-dimensional representations of tortuous vessels |
US5989189A (en) * | 1997-10-24 | 1999-11-23 | Mentor Corporation | Ophthalmic ultrasound imaging |
US5999588A (en) * | 1998-04-17 | 1999-12-07 | Adac Laboratories | Deadtime correction in a nuclear medicine imaging system |
US6191862B1 (en) * | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6608717B1 (en) * | 1999-01-29 | 2003-08-19 | Colorado State University Research Foundation | Optical coherence microscope and methods of use for rapid in vivo three-dimensional visualization of biological function |
US6445939B1 (en) * | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US20020115931A1 (en) * | 2001-02-21 | 2002-08-22 | Strauss H. William | Localizing intravascular lesions on anatomic images |
US7208333B2 (en) * | 2001-03-12 | 2007-04-24 | Axsun Technologies, Inc. | Process for fabricating MEMS membrane with integral mirror/lens |
US6570659B2 (en) * | 2001-03-16 | 2003-05-27 | Lightlab Imaging, Llc | Broadband light source system and method and light source combiner |
US6552796B2 (en) * | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US7865231B2 (en) * | 2001-05-01 | 2011-01-04 | The General Hospital Corporation | Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties |
US20030028100A1 (en) * | 2001-05-01 | 2003-02-06 | Tearney Guillermo J. | Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties |
US6879851B2 (en) * | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
US7061622B2 (en) * | 2001-08-03 | 2006-06-13 | Case Western Reserve University | Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography |
US7148970B2 (en) * | 2001-10-16 | 2006-12-12 | The General Hospital Corporation | Systems and methods for imaging a sample |
US20050201662A1 (en) * | 2002-07-25 | 2005-09-15 | Petersen Christopher L. | Scanning miniature optical probes with optical distortion correction and rotational control |
US6891984B2 (en) * | 2002-07-25 | 2005-05-10 | Lightlab Imaging, Llc | Scanning miniature optical probes with optical distortion correction and rotational control |
US20060165270A1 (en) * | 2003-02-25 | 2006-07-27 | Jorn Borgert | Intravascular imaging |
US20070260198A1 (en) * | 2003-04-25 | 2007-11-08 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7241286B2 (en) * | 2003-04-25 | 2007-07-10 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US20040215166A1 (en) * | 2003-04-25 | 2004-10-28 | Michael Atlas | Flush catheter with flow directing sheath |
US20060244973A1 (en) * | 2003-10-27 | 2006-11-02 | Seok-Hyun Yun | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US20050238067A1 (en) * | 2004-04-26 | 2005-10-27 | Choi Youngmin A | Simple fiber optic cavity |
US20060095065A1 (en) * | 2004-09-24 | 2006-05-04 | Tetsuaki Tanimura | Fluid occluding devices and methods |
US20060241465A1 (en) * | 2005-01-11 | 2006-10-26 | Volcano Corporation | Vascular image co-registration |
US20060187537A1 (en) * | 2005-01-20 | 2006-08-24 | Robert Huber | Mode locking methods and apparatus |
US7414779B2 (en) * | 2005-01-20 | 2008-08-19 | Massachusetts Institute Of Technology | Mode locking methods and apparatus |
US20060203859A1 (en) * | 2005-01-24 | 2006-09-14 | Cable Alex E | Compact multimode laser with rapid wavelength scanning |
US20060241503A1 (en) * | 2005-02-10 | 2006-10-26 | Lightlab Imaging, Inc. | Optical coherence tomography apparatus and methods |
US7415049B2 (en) * | 2005-03-28 | 2008-08-19 | Axsun Technologies, Inc. | Laser with tilted multi spatial mode resonator tuning element |
US20060241461A1 (en) * | 2005-04-01 | 2006-10-26 | White Chris A | System and method for 3-D visualization of vascular structures using ultrasound |
US20070081236A1 (en) * | 2005-09-29 | 2007-04-12 | The General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US20070123771A1 (en) * | 2005-11-04 | 2007-05-31 | Thomas Redel | Three-dimensional co-registration between intravascular and angiographic data |
US7729746B2 (en) * | 2005-11-04 | 2010-06-01 | Siemens Aktiengesellschaft | Three-dimensional co-registration between intravascular and angiographic data |
US7593559B2 (en) * | 2005-11-18 | 2009-09-22 | Duke University | Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
US20070115481A1 (en) * | 2005-11-18 | 2007-05-24 | Duke University | Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
US20090079993A1 (en) * | 2005-11-22 | 2009-03-26 | Shofu Inc. | Dental Optical Coherence Tomograph |
US7787129B2 (en) * | 2006-01-31 | 2010-08-31 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
US20080100612A1 (en) * | 2006-10-27 | 2008-05-01 | Dastmalchi Shahram S | User interface for efficiently displaying relevant oct imaging data |
US20080161696A1 (en) * | 2006-11-08 | 2008-07-03 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US20080165366A1 (en) * | 2007-01-10 | 2008-07-10 | Lightlab Imaging, Inc. | Methods and apparatus for swept-source optical coherence tomography |
US20080177183A1 (en) * | 2007-01-19 | 2008-07-24 | Brian Courtney | Imaging probe with combined ultrasounds and optical means of imaging |
US8983580B2 (en) * | 2008-01-18 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors |
Non-Patent Citations (4)
Title |
---|
FJ van der Meer, DJ Faber, DMB Sassoon, MC Aalders, G Pasterkamp, and TG van Leeuwen, "Localized Measurement of Optical Attenuation Coefficients of Atherosclerotic Plaque Constituents by Quantitative Optical Coherence Tomography," 2005, IEEE Transactions on Medical Imaging, vol. 24, no. 10, pp. 1369-1376 * |
FJ van der Meer, DJ Faber, DMB Sassoon, MC Aalders, G Pasterkamp, TG van Leeuwen, "Localized Measurement of Optical Attenuation Coefficients of Atherosclerotic Plaque Constituents by Quantitative Optical Coherence Tomography", 2005, IEEE Transactions on Medical Imaging, vol. 24, no. 10, pp. 1369-1376 * |
K Mehrotra, CK Mohan, S Ranka, âElements of Artificial Neural Networksâ, 1997, Massachusetts Institute of Technology, pp. 25-27 * |
P Gatenby, "Neural Networks, Part I: Feedforward Hardlimited Networks", 2002, http://www.hpcc.org/datafile/V21N1/neural1.html * |
Cited By (243)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9664615B2 (en) | 2004-07-02 | 2017-05-30 | The General Hospital Corporation | Imaging system and related techniques |
US9763623B2 (en) | 2004-08-24 | 2017-09-19 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US9326682B2 (en) | 2005-04-28 | 2016-05-03 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US9441948B2 (en) | 2005-08-09 | 2016-09-13 | The General Hospital Corporation | Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography |
US9516997B2 (en) | 2006-01-19 | 2016-12-13 | The General Hospital Corporation | Spectrally-encoded endoscopy techniques, apparatus and methods |
US9186066B2 (en) | 2006-02-01 | 2015-11-17 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
USRE46412E1 (en) | 2006-02-24 | 2017-05-23 | The General Hospital Corporation | Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography |
US9968245B2 (en) | 2006-10-19 | 2018-05-15 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
US8753281B2 (en) | 2006-11-08 | 2014-06-17 | Lightlab Imaging Inc. | Opto-acoustic imaging devices and methods |
US8449468B2 (en) | 2006-11-08 | 2013-05-28 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US9007696B2 (en) | 2007-11-12 | 2015-04-14 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US9572492B2 (en) | 2008-04-23 | 2017-02-21 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US10835110B2 (en) | 2008-07-14 | 2020-11-17 | The General Hospital Corporation | Apparatus and method for facilitating at least partial overlap of dispersed ration on at least one sample |
US8358461B2 (en) | 2008-09-03 | 2013-01-22 | Lightlab Imaging Inc. | Wavelength-tunable light source |
US8810901B2 (en) | 2008-09-03 | 2014-08-19 | Lightlab Imaging, Inc. | Wavelength-tunable light source |
US9615748B2 (en) | 2009-01-20 | 2017-04-11 | The General Hospital Corporation | Endoscopic biopsy apparatus, system and method |
US9642646B2 (en) | 2009-04-28 | 2017-05-09 | Avinger, Inc. | Guidewire positioning catheter |
US11076773B2 (en) | 2009-04-28 | 2021-08-03 | Avinger, Inc. | Guidewire positioning catheter |
US9788790B2 (en) | 2009-05-28 | 2017-10-17 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US10342491B2 (en) | 2009-05-28 | 2019-07-09 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US11284839B2 (en) | 2009-05-28 | 2022-03-29 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US11839493B2 (en) | 2009-05-28 | 2023-12-12 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US20120213704A1 (en) * | 2009-06-18 | 2012-08-23 | Awdeh Richard M | System and method for molecular in vivo imaging and theranostics |
US11717314B2 (en) | 2009-07-01 | 2023-08-08 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
US10052125B2 (en) | 2009-07-01 | 2018-08-21 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
US9498600B2 (en) | 2009-07-01 | 2016-11-22 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
US10729326B2 (en) | 2009-07-01 | 2020-08-04 | Avinger, Inc. | Catheter-based off-axis optical coherence tomography imaging system |
US9125562B2 (en) | 2009-07-01 | 2015-09-08 | Avinger, Inc. | Catheter-based off-axis optical coherence tomography imaging system |
US11490826B2 (en) | 2009-07-14 | 2022-11-08 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
US11234751B2 (en) | 2009-07-31 | 2022-02-01 | Case Western Reserve University | Characterizing ablation lesions using optical coherence tomography (OCT) |
US10555691B2 (en) * | 2009-08-06 | 2020-02-11 | Agency For Science Technology And Research | Vital signs detecting device and a method for detecting vital signs |
US20120203117A1 (en) * | 2009-08-06 | 2012-08-09 | Agency For Science, Technology And Research | Vital signs detecting device and a method for detecting vital signs |
US9696471B2 (en) | 2009-09-03 | 2017-07-04 | Axsun Technologies Llc | Filtered ASE swept source for OCT medical imaging |
US8526472B2 (en) | 2009-09-03 | 2013-09-03 | Axsun Technologies, Inc. | ASE swept source with self-tracking filter for OCT medical imaging |
US8670129B2 (en) | 2009-09-03 | 2014-03-11 | Axsun Technologies, Inc. | Filtered ASE swept source for OCT medical imaging |
US9041936B2 (en) | 2009-09-03 | 2015-05-26 | Axsun Technologies, Inc. | ASE swept source with self-tracking filter for OCT medical imaging |
US20110071405A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Apparatus, Systems, and Methods of in-vivo Blood Clearing in a Lumen |
US9572495B2 (en) | 2009-09-23 | 2017-02-21 | Lightlab Imaging, Inc. | Optical coherence tomography lumen morphology and vascular resistance measurements methods for blood vessel evaluations |
US8412312B2 (en) | 2009-09-23 | 2013-04-02 | Lightlab Imaging, Inc. | Apparatus, systems, and methods of in-vivo blood clearing in a lumen |
US20110071404A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US9526424B2 (en) | 2009-09-23 | 2016-12-27 | Lightlab Imaging, Inc. | Apparatus, systems, and methods of in-vivo blood clearing in a lumen |
US9138147B2 (en) | 2009-09-23 | 2015-09-22 | Lightlab Imaging, Inc. | Lumen morphology image reconstruction based on the scan line data of OCT |
WO2011072068A2 (en) | 2009-12-08 | 2011-06-16 | Avinger, Inc. | Devices and methods for predicting and preventing restenosis |
EP2509498A4 (en) * | 2009-12-08 | 2015-01-21 | Avinger Inc | DEVICES AND METHOD FOR THE PROGNOSIS AND PREVENTION OF RESTENOES |
EP2509498A2 (en) * | 2009-12-08 | 2012-10-17 | Avinger, Inc. | Devices and methods for predicting and preventing restenosis |
US8926590B2 (en) | 2009-12-22 | 2015-01-06 | Lightlab Imaging, Inc. | Torque limiter for an OCT catheter |
US20110151980A1 (en) * | 2009-12-22 | 2011-06-23 | Lightlab Imaging, Inc. | Torque limiter for an oct catheter |
US8206377B2 (en) | 2009-12-22 | 2012-06-26 | Lightlab Imaging, Inc. | Torque limiter for an OCT catheter |
US10463254B2 (en) | 2010-03-05 | 2019-11-05 | The General Hospital Corporation | Light tunnel and lens which provide extended focal depth of at least one anatomical structure at a particular resolution |
US9408539B2 (en) | 2010-03-05 | 2016-08-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US9642531B2 (en) | 2010-03-05 | 2017-05-09 | The General Hospital Corporation | Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution |
US20110228280A1 (en) * | 2010-03-17 | 2011-09-22 | Lightlab Imaging, Inc. | Intensity Noise Reduction Methods and Apparatus for Interferometric Sensing and Imaging Systems |
US10006753B2 (en) | 2010-03-17 | 2018-06-26 | Lightlab Imaging, Inc. | Intensity noise reduction methods and apparatus for interferometric sensing and imaging systems |
US8948613B2 (en) | 2010-03-17 | 2015-02-03 | Lightlab Imaging, Inc. | Intensity noise reduction methods and apparatus for interferometric sensing and imaging systems |
US8868159B2 (en) * | 2010-03-30 | 2014-10-21 | Terumo Kabushiki Kaisha | Optical imaging diagnostic apparatus and the display control method thereof |
US20110245683A1 (en) * | 2010-03-30 | 2011-10-06 | Terumo Kabushiki Kaisha | Optical imaging diagnostic apparatus and the display control method thereof |
US20110245684A1 (en) * | 2010-03-30 | 2011-10-06 | Terumo Kabushiki Kaisha | Optical imaging diagnostic apparatus and the display control method thereof |
US9468379B2 (en) | 2010-04-21 | 2016-10-18 | Koninklijke Philips N.V. | Determination of a lipid water ratio |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US9951269B2 (en) | 2010-05-03 | 2018-04-24 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US10939825B2 (en) | 2010-05-25 | 2021-03-09 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US11382653B2 (en) | 2010-07-01 | 2022-07-12 | Avinger, Inc. | Atherectomy catheter |
US10548478B2 (en) | 2010-07-01 | 2020-02-04 | Avinger, Inc. | Balloon atherectomy catheters with imaging |
US9345510B2 (en) | 2010-07-01 | 2016-05-24 | Avinger, Inc. | Atherectomy catheters with longitudinally displaceable drive shafts |
US10349974B2 (en) | 2010-07-01 | 2019-07-16 | Avinger, Inc. | Atherectomy catheters with longitudinally displaceable drive shafts |
US20120075638A1 (en) * | 2010-08-02 | 2012-03-29 | Case Western Reserve University | Segmentation and quantification for intravascular optical coherence tomography images |
US8750615B2 (en) * | 2010-08-02 | 2014-06-10 | Case Western Reserve University | Segmentation and quantification for intravascular optical coherence tomography images |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
US20130242313A1 (en) * | 2010-11-05 | 2013-09-19 | Peter Tomlins | Scanning methods and apparatus |
US8948228B2 (en) | 2011-03-15 | 2015-02-03 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US8582619B2 (en) | 2011-03-15 | 2013-11-12 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US11134849B2 (en) | 2011-03-28 | 2021-10-05 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US9949754B2 (en) | 2011-03-28 | 2018-04-24 | Avinger, Inc. | Occlusion-crossing devices |
US11903677B2 (en) | 2011-03-28 | 2024-02-20 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US10952763B2 (en) | 2011-03-28 | 2021-03-23 | Avinger, Inc. | Occlusion-crossing devices |
US9164240B2 (en) | 2011-03-31 | 2015-10-20 | Lightlab Imaging, Inc. | Optical buffering methods, apparatus, and systems for increasing the repetition rate of tunable light sources |
US9983356B2 (en) | 2011-03-31 | 2018-05-29 | Lightlab Imaging, Inc. | Optical buffer-based apparatus for increasing light source repetition rate |
JP2014516646A (ja) * | 2011-04-29 | 2014-07-17 | ザ ジェネラル ホスピタル コーポレイション | 散乱媒質の深さ分解した物理的及び/又は光学的特性を決定する方法 |
US11241154B2 (en) | 2011-05-31 | 2022-02-08 | Lightlab Imaging, Inc. | Multimodal imaging system, apparatus, and methods |
US9610064B2 (en) | 2011-05-31 | 2017-04-04 | Desmond Adler | Multimodal imaging system, apparatus, and methods |
US9330092B2 (en) | 2011-07-19 | 2016-05-03 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
US8582109B1 (en) | 2011-08-01 | 2013-11-12 | Lightlab Imaging, Inc. | Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography |
US9488464B1 (en) | 2011-08-01 | 2016-11-08 | Lightlab Imaging, Inc. | Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography |
US10648918B2 (en) | 2011-08-03 | 2020-05-12 | Lightlab Imaging, Inc. | Systems, methods and apparatus for determining a fractional flow reserve (FFR) based on the minimum lumen area (MLA) and the constant |
US20130044330A1 (en) * | 2011-08-15 | 2013-02-21 | The Johns Hopkins University | Optical coherence tomography system having real-time artifact and saturation correction |
US9250060B2 (en) * | 2011-08-15 | 2016-02-02 | The Johns Hopkins University | Optical coherence tomography system having real-time artifact and saturation correction |
US10363062B2 (en) | 2011-10-17 | 2019-07-30 | Avinger, Inc. | Atherectomy catheters and non-contact actuation mechanism for catheters |
US9341783B2 (en) | 2011-10-18 | 2016-05-17 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9435956B1 (en) | 2011-10-28 | 2016-09-06 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US8831321B1 (en) | 2011-11-07 | 2014-09-09 | Lightlab Imaging, Inc. | Side branch detection methods, systems and devices |
US9345406B2 (en) | 2011-11-11 | 2016-05-24 | Avinger, Inc. | Occlusion-crossing devices, atherectomy devices, and imaging |
US11135019B2 (en) | 2011-11-11 | 2021-10-05 | Avinger, Inc. | Occlusion-crossing devices, atherectomy devices, and imaging |
WO2013106760A1 (en) * | 2012-01-12 | 2013-07-18 | The General Hospital Corporation | Systems, methods and computer-readable medium for determining depth-resolved physical and/or optical properties of scattering media by analyzing measured data over a range of depths |
US9629528B2 (en) | 2012-03-30 | 2017-04-25 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
US9928590B2 (en) | 2012-04-23 | 2018-03-27 | Olympus Corporation | Image processing apparatus, image processing method, and computer-readable recording device for determining whether candidate region is abnormality or residue |
US10244934B2 (en) | 2012-05-14 | 2019-04-02 | Avinger, Inc. | Atherectomy catheter drive assemblies |
US10952615B2 (en) | 2012-05-14 | 2021-03-23 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
US11647905B2 (en) | 2012-05-14 | 2023-05-16 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
US11406412B2 (en) | 2012-05-14 | 2022-08-09 | Avinger, Inc. | Atherectomy catheters with imaging |
US9345398B2 (en) | 2012-05-14 | 2016-05-24 | Avinger, Inc. | Atherectomy catheter drive assemblies |
US11206975B2 (en) | 2012-05-14 | 2021-12-28 | Avinger, Inc. | Atherectomy catheter drive assemblies |
US9557156B2 (en) | 2012-05-14 | 2017-01-31 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
US9415550B2 (en) | 2012-08-22 | 2016-08-16 | The General Hospital Corporation | System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography |
US11284916B2 (en) | 2012-09-06 | 2022-03-29 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US10335173B2 (en) | 2012-09-06 | 2019-07-02 | Avinger, Inc. | Re-entry stylet for catheter |
US11510632B2 (en) | 2012-10-05 | 2022-11-29 | Philips Image Guided Therapy Corporation | Systems for indicating parameters in an imaging data set and methods of use |
EP2903533A4 (en) * | 2012-10-05 | 2016-06-22 | Elizabeth Begin | SYSTEMS FOR INDICATING PARAMETERS IN AN IMAGING DATA SET AND METHODS OF USE |
US10568586B2 (en) | 2012-10-05 | 2020-02-25 | Volcano Corporation | Systems for indicating parameters in an imaging data set and methods of use |
US11890117B2 (en) | 2012-10-05 | 2024-02-06 | Philips Image Guided Therapy Corporation | Systems for indicating parameters in an imaging data set and methods of use |
US11701089B2 (en) | 2012-11-19 | 2023-07-18 | Lightlab Imaging, Inc. | Multimodal imaging systems, probes and methods |
US10792012B2 (en) | 2012-11-19 | 2020-10-06 | Lightlab Imaging, Inc. | Interface devices, systems and methods for multimodal probes |
US10359271B2 (en) | 2012-12-05 | 2019-07-23 | Perimeter Medical Imaging, Inc. | System and method for tissue differentiation in imaging |
US9677869B2 (en) | 2012-12-05 | 2017-06-13 | Perimeter Medical Imaging, Inc. | System and method for generating a wide-field OCT image of a portion of a sample |
JP2016508750A (ja) * | 2012-12-12 | 2016-03-24 | ライトラボ・イメージング・インコーポレーテッド | 血管の内腔輪郭の自動化された決定のための方法および装置 |
US11923067B2 (en) | 2012-12-12 | 2024-03-05 | Lightlab Imaging, Inc. | Method and apparatus for automated determination of stent landing zones based on a maximum diameter of a segmented blood vessel data obtained by intravascular device |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
US11179028B2 (en) | 2013-02-01 | 2021-11-23 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
US9173591B2 (en) | 2013-03-08 | 2015-11-03 | Lightlab Imaging, Inc. | Stent visualization and malapposition detection systems, devices, and methods |
US10028725B2 (en) | 2013-03-11 | 2018-07-24 | Lightlab Imaging, Inc. | Friction torque limiter for an imaging catheter |
US9907527B2 (en) | 2013-03-12 | 2018-03-06 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US9989945B2 (en) | 2013-03-12 | 2018-06-05 | Lightlab Imaging, Inc. | Controller and user interface device, systems, and methods |
US9069396B2 (en) | 2013-03-12 | 2015-06-30 | Lightlab Imaging, Inc. | Controller and user interface device, systems, and methods |
US10687777B2 (en) | 2013-03-12 | 2020-06-23 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US9351698B2 (en) | 2013-03-12 | 2016-05-31 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US10331099B2 (en) | 2013-03-12 | 2019-06-25 | Lightlab Imaging, Inc. | Controller and user interface device, systems, and methods |
US10551251B2 (en) | 2013-03-15 | 2020-02-04 | Lightlab Imaging, Inc. | Calibration and image processing devices, methods, and systems |
US10932670B2 (en) | 2013-03-15 | 2021-03-02 | Avinger, Inc. | Optical pressure sensor assembly |
US9833221B2 (en) | 2013-03-15 | 2017-12-05 | Lightlab Imaging, Inc. | Apparatus and method of image registration |
US11890076B2 (en) | 2013-03-15 | 2024-02-06 | Avinger, Inc. | Chronic total occlusion crossing devices with imaging |
US9702762B2 (en) | 2013-03-15 | 2017-07-11 | Lightlab Imaging, Inc. | Calibration and image processing devices, methods, and systems |
US11096717B2 (en) | 2013-03-15 | 2021-08-24 | Avinger, Inc. | Tissue collection device for catheter |
US11435233B2 (en) | 2013-03-15 | 2022-09-06 | Lightlab Imaging, Inc. | Calibration and image processing devices, methods, and systems |
US11723538B2 (en) | 2013-03-15 | 2023-08-15 | Avinger, Inc. | Optical pressure sensor assembly |
US9854979B2 (en) | 2013-03-15 | 2018-01-02 | Avinger, Inc. | Chronic total occlusion crossing devices with imaging |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
US11980386B2 (en) | 2013-03-15 | 2024-05-14 | Avinger, Inc. | Tissue collection device for catheter |
US10722121B2 (en) | 2013-03-15 | 2020-07-28 | Avinger, Inc. | Chronic total occlusion crossing devices with imaging |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
US11166760B2 (en) | 2013-05-31 | 2021-11-09 | Covidien Lp | Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure |
US10722292B2 (en) | 2013-05-31 | 2020-07-28 | Covidien Lp | Surgical device with an end-effector assembly and system for monitoring of tissue during a surgical procedure |
US9892507B2 (en) | 2013-07-02 | 2018-02-13 | Michelson Diagnostics Ltd. | Processing optical coherence tomography scans of a subjects skin |
US10130386B2 (en) | 2013-07-08 | 2018-11-20 | Avinger, Inc. | Identification of elastic lamina to guide interventional therapy |
US11944342B2 (en) | 2013-07-08 | 2024-04-02 | Avinger, Inc. | Identification of elastic lamina to guide interventional therapy |
US10806484B2 (en) | 2013-07-08 | 2020-10-20 | Avinger, Inc. | Identification of elastic lamina to guide interventional therapy |
US11452433B2 (en) | 2013-07-19 | 2022-09-27 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US10058250B2 (en) | 2013-07-26 | 2018-08-28 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
US9498247B2 (en) | 2014-02-06 | 2016-11-22 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US9592075B2 (en) | 2014-02-06 | 2017-03-14 | Avinger, Inc. | Atherectomy catheters devices having multi-channel bushings |
US10470795B2 (en) | 2014-02-06 | 2019-11-12 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US10568655B2 (en) | 2014-02-06 | 2020-02-25 | Avinger, Inc. | Atherectomy catheters devices having multi-channel bushings |
US10307070B2 (en) | 2014-04-04 | 2019-06-04 | St. Jude Medical Coordination Center Bvba | Intravascular pressure and flow data diagnostic systems, devices, and methods |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
US11559218B2 (en) | 2014-04-04 | 2023-01-24 | St. Jude Medical Coordination Center Bvba | Intravascular pressure and flow data diagnostic systems, devices, and methods |
JP2016011935A (ja) * | 2014-06-30 | 2016-01-21 | 株式会社トプコン | 皮膚性状評価装置 |
US11931061B2 (en) | 2014-07-08 | 2024-03-19 | Avinger, Inc. | High speed chronic total occlusion crossing devices |
US11147583B2 (en) | 2014-07-08 | 2021-10-19 | Avinger, Inc. | High speed chronic total occlusion crossing devices |
US10357277B2 (en) | 2014-07-08 | 2019-07-23 | Avinger, Inc. | High speed chronic total occlusion crossing devices |
US11166668B2 (en) | 2014-07-24 | 2021-11-09 | Lightlab Imaging, Inc. | Pre and post stent planning along with vessel visualization and diagnostic systems, devices, and methods for automatically identifying stent expansion profile |
US10912462B2 (en) | 2014-07-25 | 2021-02-09 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
US11517199B2 (en) | 2014-08-08 | 2022-12-06 | Medlumics S.L. | Crossing coronary occlusions |
US11311200B1 (en) | 2014-08-27 | 2022-04-26 | Lightlab Imaging, Inc. | Systems and methods to measure physiological flow in coronary arteries |
US11350832B2 (en) | 2014-08-27 | 2022-06-07 | St. Jude Medical Coordination Center Bvba | Cardiac cycle-based diagnostic systems and methods |
US11883138B2 (en) | 2014-08-27 | 2024-01-30 | St. Jude Medical Coordination Center Bvba | Cardiac cycle-based diagnostic systems and methods |
US10499813B2 (en) | 2014-09-12 | 2019-12-10 | Lightlab Imaging, Inc. | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
US9940723B2 (en) | 2014-12-12 | 2018-04-10 | Lightlab Imaging, Inc. | Systems and methods to detect and display endovascular features |
US10878572B2 (en) | 2014-12-12 | 2020-12-29 | Lightlab Imaging, Inc. | Systems and methods to detect and display endovascular features |
US11461902B2 (en) | 2014-12-12 | 2022-10-04 | Lightlab Imaging, Inc. | Systems and methods to detect and display endovascular features |
US20160270766A1 (en) * | 2015-03-20 | 2016-09-22 | Terumo Kabushiki Kaisha | Diagnostic imaging apparatus, control method, program, and computer-readable storage medium |
US10485518B2 (en) * | 2015-03-20 | 2019-11-26 | Terumo Kabushiki Kaisha | Diagnostic imaging apparatus, control method, program, and computer-readable storage medium |
US11278206B2 (en) | 2015-04-16 | 2022-03-22 | Gentuity, Llc | Micro-optic probes for neurology |
US10902599B2 (en) | 2015-05-17 | 2021-01-26 | Lightlab Imaging, Inc. | Stent detection methods and imaging system interfaces |
US10222956B2 (en) | 2015-05-17 | 2019-03-05 | Lightlab Imaging, Inc. | Intravascular imaging user interface systems and methods |
US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
US10140712B2 (en) | 2015-05-17 | 2018-11-27 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
US11367186B2 (en) | 2015-05-17 | 2022-06-21 | Lightlab Imaging, Inc. | Detection of metal stent struts |
US10646198B2 (en) | 2015-05-17 | 2020-05-12 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US10713786B2 (en) | 2015-05-17 | 2020-07-14 | Lightlab Imaging, Inc. | Detection of metal stent struts |
US11532087B2 (en) | 2015-05-17 | 2022-12-20 | Lightlab Imaging, Inc. | Stent detection methods and imaging system interfaces |
US11033190B2 (en) | 2015-07-13 | 2021-06-15 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US10568520B2 (en) | 2015-07-13 | 2020-02-25 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US11627881B2 (en) | 2015-07-13 | 2023-04-18 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US11974830B2 (en) | 2015-07-13 | 2024-05-07 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US11768593B2 (en) * | 2015-07-25 | 2023-09-26 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US10089755B2 (en) | 2015-07-25 | 2018-10-02 | Lightlab Imaging, Inc. | Guidewire detection systems, methods, and apparatuses |
US20220244841A1 (en) * | 2015-07-25 | 2022-08-04 | Lightlab Imaging, Inc. | Intravascular Data Visualization And Interface Systems And Methods |
US10529093B2 (en) | 2015-07-25 | 2020-01-07 | Lightlab Imaging, Inc. | Guidewire detection systems, methods, and apparatuses |
US11287961B2 (en) * | 2015-07-25 | 2022-03-29 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US10338795B2 (en) * | 2015-07-25 | 2019-07-02 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US11937786B2 (en) | 2015-08-31 | 2024-03-26 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US10631718B2 (en) | 2015-08-31 | 2020-04-28 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US11583172B2 (en) | 2015-08-31 | 2023-02-21 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US11064873B2 (en) | 2015-08-31 | 2021-07-20 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US10327726B2 (en) | 2015-11-18 | 2019-06-25 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US11633167B2 (en) | 2015-11-18 | 2023-04-25 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10453196B2 (en) | 2015-11-18 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
US10172582B2 (en) | 2015-11-18 | 2019-01-08 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US11020078B2 (en) | 2015-11-18 | 2021-06-01 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10342502B2 (en) | 2015-11-18 | 2019-07-09 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US11850089B2 (en) | 2015-11-19 | 2023-12-26 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US10453190B2 (en) | 2015-11-23 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of and validation of shadows in intravascular images |
US11278248B2 (en) | 2016-01-25 | 2022-03-22 | Avinger, Inc. | OCT imaging catheter with lag correction |
US11957376B2 (en) | 2016-04-01 | 2024-04-16 | Avinger, Inc. | Atherectomy catheter with serrated cutter |
US11399863B2 (en) | 2016-04-01 | 2022-08-02 | Avinger, Inc. | Atherectomy catheter with serrated cutter |
US11475560B2 (en) | 2016-04-14 | 2022-10-18 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
US10593037B2 (en) | 2016-04-14 | 2020-03-17 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
US10631754B2 (en) | 2016-05-16 | 2020-04-28 | Lightlab Imaging, Inc. | Intravascular absorbable stent detection and diagnostic methods and systems |
CN105996999A (zh) * | 2016-05-19 | 2016-10-12 | 南京航空航天大学 | 基于oct测量样品深度分辨衰减系数的方法和系统 |
US11344327B2 (en) | 2016-06-03 | 2022-05-31 | Avinger, Inc. | Catheter device with detachable distal end |
JP2022095854A (ja) * | 2016-06-08 | 2022-06-28 | リサーチ ディヴェロプメント ファウンデーション | 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法 |
KR102531819B1 (ko) * | 2016-06-08 | 2023-05-16 | 리서치 디벨럽먼트 파운데이션 | 혈관내 광 간섭 단층촬영법을 사용한 자동 관상동맥 플라크 특징화 및 위험 평가를 위한 시스템들 및 방법들 |
KR20190015546A (ko) * | 2016-06-08 | 2019-02-13 | 리서치 디벨럽먼트 파운데이션 | 혈관내 광학 코히어런스 토모그래피를 사용한 자동 관상동맥 경화반 특징화 및 위험 평가를 위한 시스템들 및 방법들 |
WO2017214421A1 (en) * | 2016-06-08 | 2017-12-14 | Research Development Foundation | Systems and methods for automated coronary plaque characterization and risk assessment using intravascular optical coherence tomography |
JP7383070B2 (ja) | 2016-06-08 | 2023-11-17 | リサーチ ディヴェロプメント ファウンデーション | 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法 |
AU2017277784B2 (en) * | 2016-06-08 | 2022-06-30 | Research Development Foundation | Systems and methods for automated coronary plaque characterization and risk assessment using intravascular optical coherence tomography |
US11224459B2 (en) | 2016-06-30 | 2022-01-18 | Avinger, Inc. | Atherectomy catheter with shapeable distal tip |
US11883107B2 (en) | 2016-09-28 | 2024-01-30 | Lightlab Imaging, Inc. | Stent planning systems and methods using vessel representation obtained via intravascular probe by determining stent effectiveness score and fractional flow reserve |
US11357403B2 (en) | 2016-10-28 | 2022-06-14 | Fujifilm Corporation | Optical coherence tomography apparatus and measurement method |
US10577573B2 (en) | 2017-07-18 | 2020-03-03 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
US10894939B2 (en) | 2017-07-18 | 2021-01-19 | Perimeter Medical Imaging, Inc. | Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis |
US11058346B2 (en) | 2017-10-30 | 2021-07-13 | Wenzhou Medical University | Optical imaging method based on mapping of layered structure |
US11684242B2 (en) | 2017-11-28 | 2023-06-27 | Gentuity, Llc | Imaging system |
US11464412B2 (en) | 2017-12-27 | 2022-10-11 | Medlumics S.L. | Bi-refringence compensated waveguides |
US11344373B2 (en) | 2018-05-29 | 2022-05-31 | Lightlab Imaging, Inc. | Stent expansion display, systems, and methods |
US11779220B2 (en) | 2018-12-14 | 2023-10-10 | Research Development Foundation | Multi-channel orthogonal convolutional neural networks |
US11992329B2 (en) | 2019-06-19 | 2024-05-28 | Michelson Diagnostics Ltd. | Processing optical coherence tomography scans |
US11793400B2 (en) | 2019-10-18 | 2023-10-24 | Avinger, Inc. | Occlusion-crossing devices |
US11331142B2 (en) | 2020-01-13 | 2022-05-17 | Medlumics S.L. | Methods, devices, and support structures for assembling optical fibers in catheter tips |
US11357569B2 (en) | 2020-01-13 | 2022-06-14 | Medlumics S.L. | Optical-guided ablation system for use with pulsed fields or other energy sources |
US11523740B2 (en) | 2020-01-13 | 2022-12-13 | Medlumics S.L. | Systems and methods for optical analysis and lesion prediction using ablation catheters |
WO2022087378A1 (en) * | 2020-10-23 | 2022-04-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Data acquisition and measurement of characteristic functionals in biology and medicine |
CN113876357A (zh) * | 2020-11-04 | 2022-01-04 | 科特有限责任公司 | 具有可滑动套管的成像及压力传感装置和探头 |
US11998311B2 (en) | 2021-07-26 | 2024-06-04 | Avinger, Inc. | Guidewire positioning catheter |
CN114489151A (zh) * | 2021-12-13 | 2022-05-13 | 中国地质科学院矿产资源研究所 | 一种激光器输出功率控制装置及其控制方法 |
WO2023183420A1 (en) * | 2022-03-22 | 2023-09-28 | Case Western Reserve University | Methods, systems and apparatuses for transseptal procedures |
CN114820605A (zh) * | 2022-06-28 | 2022-07-29 | 广州永士达医疗科技有限责任公司 | 一种咽鼓管oct图像识别处理方法及装置 |
Also Published As
Publication number | Publication date |
---|---|
EP2293714A1 (en) | 2011-03-16 |
US20180192957A1 (en) | 2018-07-12 |
JP2011521747A (ja) | 2011-07-28 |
ES2517915T3 (es) | 2014-11-04 |
WO2009149131A1 (en) | 2009-12-10 |
EP2293714B1 (en) | 2014-08-13 |
US11793462B2 (en) | 2023-10-24 |
US20230414176A1 (en) | 2023-12-28 |
JP2014097417A (ja) | 2014-05-29 |
CN102046071B (zh) | 2013-11-06 |
JP2015231526A (ja) | 2015-12-24 |
CN102046071A (zh) | 2011-05-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230414176A1 (en) | Intravascular Measurement And Data Collections Systems, Apparatus And Methods | |
US11510632B2 (en) | Systems for indicating parameters in an imaging data set and methods of use | |
US11461902B2 (en) | Systems and methods to detect and display endovascular features | |
US11532087B2 (en) | Stent detection methods and imaging system interfaces | |
US10335039B2 (en) | Methods for stent strut detection and related measurement and display using optical coherence tomography | |
EP3297532B1 (en) | Intravascular imaging system interfaces and stent detection methods | |
US9858668B2 (en) | Guidewire artifact removal in images | |
AU2016265949A1 (en) | Intravascular imaging system interfaces and shadow detection methods | |
EP2903513A2 (en) | Automatic stent detection | |
JP2014516646A (ja) | 散乱媒質の深さ分解した物理的及び/又は光学的特性を決定する方法 | |
Zahnd et al. | Quantification of fibrous cap thickness in intracoronary optical coherence tomography with a contour segmentation method based on dynamic programming | |
EP2964089A1 (en) | Stent visualization and malapposition detection systems, devices, and methods | |
EP3865050A1 (en) | Image processing apparatus, method and storage medium to determine longitudinal orientation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: LIGHTLAB IMAGING, INC., MASSACHUSETTS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SCHMITT, JOSEPH M.;XU, CHENYANG;REEL/FRAME:023124/0667 Effective date: 20090806 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |