TWI318571B - Formulation of a thienopyridine platelet aggregation inhibitor - Google Patents
Formulation of a thienopyridine platelet aggregation inhibitorInfo
- Publication number
- TWI318571B TWI318571B TW095119687A TW95119687A TWI318571B TW I318571 B TWI318571 B TW I318571B TW 095119687 A TW095119687 A TW 095119687A TW 95119687 A TW95119687 A TW 95119687A TW I318571 B TWI318571 B TW I318571B
- Authority
- TW
- Taiwan
- Prior art keywords
- formulation
- platelet aggregation
- aggregation inhibitor
- thienopyridine
- thienopyridine platelet
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68918305P | 2005-06-10 | 2005-06-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200718420A TW200718420A (en) | 2007-05-16 |
TWI318571B true TWI318571B (en) | 2009-12-21 |
Family
ID=37198935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095119687A TWI318571B (en) | 2005-06-10 | 2006-06-02 | Formulation of a thienopyridine platelet aggregation inhibitor |
Country Status (35)
Country | Link |
---|---|
US (1) | US20080176893A1 (zh) |
EP (1) | EP1896019B1 (zh) |
JP (1) | JP2008543755A (zh) |
KR (2) | KR20100076050A (zh) |
CN (1) | CN101193633B (zh) |
AR (1) | AR054283A1 (zh) |
AT (1) | ATE441413T1 (zh) |
AU (1) | AU2006258102B2 (zh) |
BR (1) | BRPI0611350B8 (zh) |
CA (1) | CA2611668C (zh) |
CY (1) | CY1109502T1 (zh) |
DE (1) | DE602006008942D1 (zh) |
DK (1) | DK1896019T3 (zh) |
DO (1) | DOP2006000126A (zh) |
EA (1) | EA011693B1 (zh) |
EC (1) | ECSP077984A (zh) |
ES (1) | ES2330373T3 (zh) |
HK (1) | HK1116422A1 (zh) |
HR (1) | HRP20090516T1 (zh) |
IL (1) | IL187830A0 (zh) |
MA (1) | MA29688B1 (zh) |
MX (1) | MX2007015431A (zh) |
MY (1) | MY151038A (zh) |
NO (1) | NO20076317L (zh) |
NZ (1) | NZ564003A (zh) |
PE (1) | PE20070320A1 (zh) |
PL (1) | PL1896019T3 (zh) |
PT (1) | PT1896019E (zh) |
RS (1) | RS51194B (zh) |
SI (1) | SI1896019T1 (zh) |
TN (1) | TNSN07466A1 (zh) |
TW (1) | TWI318571B (zh) |
UA (1) | UA91051C2 (zh) |
WO (1) | WO2006135605A2 (zh) |
ZA (1) | ZA200710697B (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008072535A1 (ja) * | 2006-12-07 | 2008-06-19 | Daiichi Sankyo Company, Limited | 低置換度ヒドロキシプロピルセルロースを含有する医薬組成物 |
KR101503083B1 (ko) * | 2006-12-07 | 2015-03-16 | 다이이찌 산쿄 가부시키가이샤 | 고형 제제의 제조 방법 |
KR101647842B1 (ko) * | 2006-12-07 | 2016-08-11 | 다이이찌 산쿄 가부시키가이샤 | 저장 안정성이 개선된 의약 조성물 |
EP2100609A4 (en) * | 2006-12-07 | 2010-01-06 | Daiichi Sankyo Co Ltd | MEDICAL PREPARATION IN SOLID FORM CONTAINING MANNITOL OR LACTOSE |
AU2007333302A1 (en) * | 2006-12-07 | 2008-06-19 | Eli Lilly And Company | An article comprising prasugrel |
KR101665705B1 (ko) * | 2006-12-07 | 2016-10-12 | 다이이찌 산쿄 가부시키가이샤 | 안정성이 개선된 필름 코팅 제제 |
CN102424686A (zh) * | 2007-03-02 | 2012-04-25 | 第一三共株式会社 | 用于制备高纯度普拉格雷盐酸盐的方法 |
KR20160033792A (ko) | 2007-04-27 | 2016-03-28 | 사이덱스 파마슈티칼스, 인크. | 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법 |
GB2450117A (en) * | 2007-06-13 | 2008-12-17 | Reckitt Benckiser Healthcare | A water- and oxygen-occlusive blister tablet pack |
WO2009098142A1 (en) * | 2008-02-06 | 2009-08-13 | Helm Ag | Prasugrel salts with improved properties |
EP2107061A1 (en) * | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
DE602008002820D1 (de) * | 2008-04-25 | 2010-11-11 | Sandoz Ag | Hydrogensulfat von 2-Acetoxy-5-(a-cyclopropylcarbonyl-2-fluorbenzyl)-4,5,6,7-tetrahydrothienoÄ3,2-cÜpyridin und dessen Zubereitung |
EA024980B1 (ru) * | 2009-02-17 | 2016-11-30 | КРКА, д.д., НОВО МЕСТО | Лекарственные формы, содержащие основание прасугреля или его фармацевтически приемлемые соли присоединения кислоты, и способы их приготовления |
US8236782B2 (en) | 2009-05-13 | 2012-08-07 | Cydex Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
DE102009036646A1 (de) | 2009-08-07 | 2011-02-10 | Ratiopharm Gmbh | Prasugrel in nicht-kristalliner Form und pharmazeutische Zusammensetzung davon |
WO2011052499A1 (ja) * | 2009-10-28 | 2011-05-05 | 第一三共株式会社 | 貯蔵安定性が改善された医薬組成物 |
JP2013032289A (ja) * | 2009-10-28 | 2013-02-14 | Daiichi Sankyo Co Ltd | ワックス安定製剤 |
WO2011092720A2 (en) * | 2010-02-01 | 2011-08-04 | Msn Laboratories Limited | Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts |
TR201005900A1 (tr) | 2010-07-19 | 2012-02-21 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Geliştirilmiş stabiliteye sahip prasugrel granülleri. |
TR201006802A1 (tr) * | 2010-08-17 | 2012-03-21 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Prasugrelin oral yolla dağılan formülasyonları. |
TR201007926A1 (tr) | 2010-07-19 | 2012-02-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Prasugrel tablet formülasyonları. |
EP2409685A3 (en) | 2010-07-19 | 2012-02-01 | Sanovel Ilac Sanayi ve Ticaret A.S. | Orally-disintegrating formulations of prasugrel |
CZ2011872A3 (cs) | 2011-12-22 | 2013-07-03 | Zentiva, K.S. | Farmaceutická formulace prasugrelu hydrobromidu |
US8603537B2 (en) | 2012-04-02 | 2013-12-10 | Egis Pharmaceuticals Plc | Prasugrel containing quickly released stable oral pharmaceutical compositions |
WO2014060554A1 (en) | 2012-10-19 | 2014-04-24 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Prasugrel formulations |
WO2014060560A1 (en) | 2012-10-19 | 2014-04-24 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Solid oral formulations of prasugrel |
CN102993210A (zh) * | 2012-12-19 | 2013-03-27 | 苏春华 | 一种吡啶并噻吩的新化合物 |
EP2979693A1 (en) | 2014-08-01 | 2016-02-03 | Zaklady Farmaceutyczne Polpharma SA | Pharmaceutical composition comprising prasugrel or pharmaceutically acceptable salt thereof and process for its preparation |
WO2016122421A1 (en) | 2015-01-29 | 2016-08-04 | Pharmactive Ilaç Sanayi Ve Ticaret A.Ş. | Stable pharmaceutical compositions containing prasugrel base |
EP3158993A1 (en) | 2015-10-22 | 2017-04-26 | Zaklady Farmaceutyczne Polpharma SA | Process for preparing a tablet comprising prasugrel or pharmaceutically acceptable salt thereof |
CN107304216A (zh) * | 2016-04-20 | 2017-10-31 | 陕西合成药业股份有限公司 | 噻吩吡啶类衍生物及其制备方法和用途 |
HU231079B1 (hu) | 2016-06-23 | 2020-06-29 | Richter Gedeon Nyrt. | Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával |
GR1009230B (el) | 2016-10-12 | 2018-02-22 | Φαρματεν Αβεε | Φαρμακευτικο σκευασμα που περιλαμβανει βεσυλικη πρασουγρελη |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
PT1728794E (pt) * | 2000-07-06 | 2008-07-15 | Ube Industries | Sal de adição maleato de derivados de hidropiridina |
JP4001199B2 (ja) * | 2000-07-06 | 2007-10-31 | 第一三共株式会社 | ヒドロピリジン誘導体酸付加塩 |
EP1243524A3 (en) * | 2001-03-16 | 2004-04-07 | Pfizer Products Inc. | Pharmaceutical kit for oxygen-sensitive drugs |
JP4394873B2 (ja) * | 2001-12-19 | 2010-01-06 | 武田薬品工業株式会社 | 酸素に不安定な化合物を含有する固形組成物およびその安定化方法 |
SI21302A (sl) * | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
US20050020554A1 (en) * | 2003-06-06 | 2005-01-27 | Ahmed Salah U. | Stability of hormone formulations |
DE602004010817T2 (de) * | 2003-08-05 | 2008-12-11 | Zentiva, A.S. | Verfahren zur stabilisierung von atorvastatin |
-
2006
- 2006-06-02 TW TW095119687A patent/TWI318571B/zh active
- 2006-06-06 JP JP2008515813A patent/JP2008543755A/ja active Pending
- 2006-06-06 AT AT06772240T patent/ATE441413T1/de active
- 2006-06-06 US US11/913,889 patent/US20080176893A1/en not_active Abandoned
- 2006-06-06 CA CA2611668A patent/CA2611668C/en not_active Expired - Fee Related
- 2006-06-06 PL PL06772240T patent/PL1896019T3/pl unknown
- 2006-06-06 EA EA200702670A patent/EA011693B1/ru not_active IP Right Cessation
- 2006-06-06 NZ NZ564003A patent/NZ564003A/en not_active IP Right Cessation
- 2006-06-06 ES ES06772240T patent/ES2330373T3/es active Active
- 2006-06-06 WO PCT/US2006/021860 patent/WO2006135605A2/en active Application Filing
- 2006-06-06 RS RSP-2009/0425A patent/RS51194B/sr unknown
- 2006-06-06 PT PT06772240T patent/PT1896019E/pt unknown
- 2006-06-06 DO DO2006000126A patent/DOP2006000126A/es unknown
- 2006-06-06 DE DE602006008942T patent/DE602006008942D1/de active Active
- 2006-06-06 EP EP06772240A patent/EP1896019B1/en not_active Revoked
- 2006-06-06 SI SI200630490T patent/SI1896019T1/sl unknown
- 2006-06-06 AU AU2006258102A patent/AU2006258102B2/en not_active Ceased
- 2006-06-06 UA UAA200712993A patent/UA91051C2/ru unknown
- 2006-06-06 DK DK06772240T patent/DK1896019T3/da active
- 2006-06-06 KR KR1020107011742A patent/KR20100076050A/ko not_active Application Discontinuation
- 2006-06-06 KR KR1020077028749A patent/KR20080008413A/ko not_active Application Discontinuation
- 2006-06-06 BR BRPI0611350A patent/BRPI0611350B8/pt active IP Right Grant
- 2006-06-06 MX MX2007015431A patent/MX2007015431A/es active IP Right Grant
- 2006-06-06 CN CN2006800205289A patent/CN101193633B/zh active Active
- 2006-06-08 PE PE2006000641A patent/PE20070320A1/es not_active Application Discontinuation
- 2006-06-09 MY MYPI20062708 patent/MY151038A/en unknown
- 2006-06-09 AR AR20060102430A patent/AR054283A1/es unknown
-
2007
- 2007-12-03 IL IL187830A patent/IL187830A0/en unknown
- 2007-12-07 ZA ZA200710697A patent/ZA200710697B/xx unknown
- 2007-12-07 NO NO20076317A patent/NO20076317L/no not_active Application Discontinuation
- 2007-12-07 EC EC2007007984A patent/ECSP077984A/es unknown
- 2007-12-07 TN TNP2007000466A patent/TNSN07466A1/en unknown
-
2008
- 2008-01-09 MA MA30568A patent/MA29688B1/fr unknown
- 2008-06-20 HK HK08106909.9A patent/HK1116422A1/xx not_active IP Right Cessation
-
2009
- 2009-09-25 HR HR20090516T patent/HRP20090516T1/xx unknown
- 2009-10-22 CY CY20091101101T patent/CY1109502T1/el unknown
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