TR199800347T1 - Micro-poring of human skin for drug application and monitoring applications. - Google Patents
Micro-poring of human skin for drug application and monitoring applications.Info
- Publication number
- TR199800347T1 TR199800347T1 TR1998/00347T TR9800347T TR199800347T1 TR 199800347 T1 TR199800347 T1 TR 199800347T1 TR 1998/00347 T TR1998/00347 T TR 1998/00347T TR 9800347 T TR9800347 T TR 9800347T TR 199800347 T1 TR199800347 T1 TR 199800347T1
- Authority
- TR
- Turkey
- Prior art keywords
- corneum
- startum
- micro
- poring
- sonic energy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Laser Surgery Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Deride tedavi amaçli ilaç ya da teshis amaçli analit tatbikinde derinin (120.274) nüfuz edici özelligini artiran yöntem, mikrogözeneklendirme, istege bagli sonik enerji ve kimyasal genisleticiden faydalanilarak tanimlanmistir. Uygulandigi takdirde sonik enerji frekans modülasyonu, sia modülasyonu faz modülasyonu ve /veya bunlarin kombinasyonlarindan olusturulmus araçlarla modüle edilebilir. Mikrogözeneklendirme su yöntemlerden biriyle elde edilir; (a) suyun lokal olarak çok hizli bir sekilde isinarak buharlasmasi ve böylece hücreleri asindirmasiyla startum korneum (274) haline ulasilmasi, (b) startum korneumun delinmesi; (c) startum korneum üzerine odaklanan sonik enerjiyle startum korneum (274) haline ulasilmasi; (d) yaklasik 1000 *m'ye kadar ulasan mikro-gözenek olusturmak için startum korneum (274) yüksek basinçli su tazyikiyle delinmesi, ya da (e) yaklasik 1000 *m'ye kadar ulasan mikro-gözenek olusturmak için kisa elektrik akimlari uygulayarak startum korneumun delinmesi.The method that increases the penetrating property of the skin (120,274) in the treatment of drug for the purpose of treatment or analyte in the skin is defined by making use of microporosification, optional sonic energy and chemical expander. If applicable, sonic energy can be modulated by means of frequency modulation, sia modulation, phase modulation and / or combinations thereof. Microporosing is achieved by one of the water methods; (a) the water evaporates locally very rapidly and thereby corrodes the cells to reach startum corneum (274), (b) pierce startum corneum; (c) reaching the startum corneum (274) with sonic energy focused on the startum corneum; (d) start-up to create micro-pores reaching up to approx. 1000 * m. puncture of the corneum.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52054795A | 1995-08-29 | 1995-08-29 | |
US804395P | 1995-10-30 | 1995-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199800347T1 true TR199800347T1 (en) | 1998-05-21 |
Family
ID=26677684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/00347T TR199800347T1 (en) | 1995-08-29 | 1996-08-29 | Micro-poring of human skin for drug application and monitoring applications. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0858285A4 (en) |
JP (2) | JP3899427B2 (en) |
CN (1) | CN1174713C (en) |
AU (1) | AU707065B2 (en) |
BR (1) | BR9610012A (en) |
CA (1) | CA2199002C (en) |
ES (1) | ES2536459T3 (en) |
GB (1) | GB2307414B (en) |
HK (1) | HK1009321A1 (en) |
IL (1) | IL123379A (en) |
NO (1) | NO334437B1 (en) |
PT (1) | PT1563788E (en) |
TR (1) | TR199800347T1 (en) |
WO (1) | WO1997007734A1 (en) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6315772B1 (en) | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
ATE234129T1 (en) | 1996-06-18 | 2003-03-15 | Alza Corp | DEVICE FOR IMPROVING TRANSDERMAL ADMINISTRATION OF MEDICATIONS OR EXTRACTION OF BODY FLUID |
DE69722414T2 (en) * | 1996-07-03 | 2004-05-19 | Altea Therapeutics Corp. | MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA |
DE69718495T2 (en) * | 1996-09-17 | 2003-11-20 | Deka Products Lp | SYSTEM FOR DISPOSAL OF MEDICINE BY TRANSPORT |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
EP0952850A2 (en) * | 1996-12-31 | 1999-11-03 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
US6027496A (en) | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
WO1999020181A1 (en) | 1997-10-21 | 1999-04-29 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6155992A (en) * | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
EP1037686B1 (en) * | 1997-12-11 | 2005-08-17 | Alza Corporation | Device for enhancing transdermal agent flux |
CA2313458C (en) * | 1997-12-11 | 2007-04-17 | Alza Corporation | Device for enhancing transdermal agent flux |
WO1999029298A2 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
ATE375752T1 (en) * | 1998-03-06 | 2007-11-15 | Spectrx Inc | INTEGRATED TISSUE PORATION, FLUID COLLECTION AND ANALYSIS DEVICE |
US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
US6530915B1 (en) | 1998-03-06 | 2003-03-11 | Spectrx, Inc. | Photothermal structure for biomedical applications, and method therefor |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6569157B1 (en) * | 1998-05-18 | 2003-05-27 | Abbott Laboratories | Removal of stratum corneum by means of light |
US6077660A (en) * | 1998-06-10 | 2000-06-20 | Abbott Laboratories | Diagnostic assay requiring a small sample of biological fluid |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
DK1124607T3 (en) | 1998-07-14 | 2009-01-26 | Altea Therapeutics Corp | Controlled biological membrane removal using pyrotechnic charge for transmembrane transport |
DE69937738D1 (en) * | 1998-07-21 | 2008-01-24 | Altea Therapeutics Corp | METHOD AND DEVICE FOR THE CONTINUOUS MONITORING OF AN ANALYTE |
US7384396B2 (en) | 1998-07-21 | 2008-06-10 | Spectrx Inc. | System and method for continuous analyte monitoring |
JP2002524120A (en) * | 1998-09-04 | 2002-08-06 | パウダージェクト リサーチ リミテッド | Monitoring method using particle delivery method |
US6468229B1 (en) | 1998-10-20 | 2002-10-22 | Abbott Laboratories | Apparatus and method for the collection of interstitial fluids |
US6708060B1 (en) | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
US6597946B2 (en) | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
EP1645305A1 (en) * | 1999-06-08 | 2006-04-12 | Altea Therapeutics Corporation | Apparatus for microporation of biological membranes using thin film tissue interface devices, and method for manufacturing |
US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6355054B1 (en) * | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
DE19963034A1 (en) | 1999-12-24 | 2001-06-28 | Roche Diagnostics Gmbh | Glucose level detection system based on measurement of interstitial fluid, uses heating device or ultrasound to reduce time offset between concentration in interstitial fluid and blood |
IL136008A0 (en) | 2000-05-07 | 2001-05-20 | Elecsys Ltd | Electrically-mediated transdermal drug injection |
US6706032B2 (en) | 2000-06-08 | 2004-03-16 | Massachusetts Institute Of Technology | Localized molecular and ionic transport to and from tissues |
US7597692B2 (en) | 2000-06-08 | 2009-10-06 | Massachusetts Institute Of Technology | Microscission processes and procedures |
AUPR044000A0 (en) * | 2000-09-28 | 2000-10-26 | Norwood Abbey Ltd | Diagnostic device |
US6537243B1 (en) | 2000-10-12 | 2003-03-25 | Abbott Laboratories | Device and method for obtaining interstitial fluid from a patient for diagnostic tests |
US6882884B1 (en) | 2000-10-13 | 2005-04-19 | Soundskin, L.L.C. | Process for the stimulation of production of extracellular dermal proteins in human tissue |
US6733493B2 (en) * | 2000-11-16 | 2004-05-11 | Innotech Usa, Inc. | Laser skin perforator |
EP1345646A2 (en) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
AU2002231207A1 (en) | 2000-12-21 | 2002-07-01 | Biovalve Technologies, Inc. | Microneedle array systems |
JP4704583B2 (en) * | 2001-02-28 | 2011-06-15 | 有限会社開発顧問室 | Patch test sheet |
US6855117B2 (en) | 2001-08-01 | 2005-02-15 | Johnson & Johnson Consumer Companies, Inc. | Method of treating the skin of a subject |
US6790179B2 (en) | 2001-08-01 | 2004-09-14 | Johnson & Johnson Consumer Companies, Inc. | Method of examining and diagnosing skin health |
US6840910B2 (en) | 2001-08-01 | 2005-01-11 | Johnson & Johnson Consumer Companies, Inc. | Method of distributing skin care products |
US8361037B2 (en) | 2001-09-19 | 2013-01-29 | Valeritas, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
DE60239229D1 (en) | 2001-09-21 | 2011-03-31 | Valeritas Inc | GAS PRESSURE-OPERATED MICRONADEL ARRANGEMENTS AND ASSOCIATED SYSTEMS AND METHODS THEREOF |
EP2319577B1 (en) | 2001-11-07 | 2017-03-15 | Syneron Medical Ltd. | Integrated transdermal drug delivery system |
US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
WO2003077971A2 (en) | 2002-03-11 | 2003-09-25 | Altea Therapeutics Corporation | Transdermal drug delivery patch system, method of making same and method of using same |
EP1499255B1 (en) | 2002-04-19 | 2015-07-22 | Syneron Medical Ltd. | Handheld transdermal drug delivery and analyte extraction |
US7383084B2 (en) | 2002-10-31 | 2008-06-03 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | Transdermal delivery system for water insoluble drugs |
IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | Transdermal delivery system for anti-emetic medication |
IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | Transdermal delivery system for dried particulate or lyophilized medications |
US7662404B2 (en) | 2002-10-31 | 2010-02-16 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides |
US8133505B2 (en) | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
US7258673B2 (en) | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US8016811B2 (en) | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
KR20060108682A (en) * | 2003-10-24 | 2006-10-18 | 알자 코포레이션 | Pretreatment method and system for enhancing transdermal drug delivery |
WO2005041871A2 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Apparatus and method for enhancing transdermal drug delivery |
CA2584800A1 (en) | 2004-10-21 | 2006-05-04 | Bayer Healthcare Llc | Method of determining the concentration of an analyte in a body fluid and system therefor |
JP2006326147A (en) * | 2005-05-30 | 2006-12-07 | Shingo Wakamatsu | Laser therapy equipment |
TWI419717B (en) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | Permeant delivery system and methods for use thereof |
JP5011936B2 (en) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | Blood test equipment |
JP5011935B2 (en) * | 2006-10-11 | 2012-08-29 | パナソニック株式会社 | Blood test equipment |
EP2103324B1 (en) * | 2006-11-14 | 2013-07-03 | Kagoshima University | Drug injecting device |
US8386027B2 (en) | 2007-04-27 | 2013-02-26 | Echo Therapeutics, Inc. | Skin permeation device for analyte sensing or transdermal drug delivery |
WO2009047774A2 (en) | 2007-10-09 | 2009-04-16 | Transpharma Ltd. | Magnetic patch coupling |
US8281675B2 (en) | 2007-10-17 | 2012-10-09 | Syneron Medical Ltd | Dissolution rate verification |
JP5407868B2 (en) * | 2007-11-06 | 2014-02-05 | コニカミノルタ株式会社 | Micro-aperture forming apparatus and body fluid collecting system using the same |
JP2011505899A (en) | 2007-12-05 | 2011-03-03 | シネロン メディカル リミテッド | Disposable electromagnetic energy applicator and method of using the same |
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
US20100256466A1 (en) * | 2009-04-02 | 2010-10-07 | Avraham Shekalim | Metabolite Management System |
US9402678B2 (en) | 2009-07-27 | 2016-08-02 | Novoxel Ltd. | Methods and devices for tissue ablation |
PT105635B (en) * | 2011-04-19 | 2014-04-11 | Univ De Coimbra | DEVICE FOR THE EFFICIENT ADMINISTRATION OF COMPOUNDS IN THE SKIN OR BIOLOGICAL BARRIERS, OR THROUGH THEM, USING FINE ABSORBENT LIGHT FILMS |
JP2017503564A (en) | 2013-12-18 | 2017-02-02 | ノヴォクセル リミテッド | Tissue vaporization apparatus and method |
KR20170058972A (en) * | 2014-09-15 | 2017-05-29 | 노보셀 리미티드 | Methods and devices for thermal surgical vaporization and incision of tissue |
EP3193761B1 (en) | 2014-09-15 | 2021-03-24 | Novoxel Ltd. | Methods for manufacturing devices for thermal tissue vaporization and compression |
EP3265168A1 (en) * | 2015-03-03 | 2018-01-10 | Guided Therapy Systems, L.L.C. | Methods and systems for ultrasound assisted delivery of a medicant to tissue |
EP3389486A1 (en) * | 2015-12-15 | 2018-10-24 | Koninklijke Philips N.V. | Surface treatment device and method |
EP3403092A4 (en) * | 2016-01-15 | 2019-08-28 | University of Cincinnati | Advanced electroporation devices and methods for analyte access in biofluids |
CA3028407A1 (en) * | 2016-06-20 | 2017-12-28 | University Of North Texas | Laser-assisted machining (lam) of non-monolithic composite bone material |
FI127811B (en) * | 2016-11-21 | 2019-03-15 | Helsingin Yliopisto | Device for sampling one or more analytes |
EP3361402A1 (en) * | 2017-02-14 | 2018-08-15 | Roche Diabetes Care GmbH | A computer-implemented method and a portable device for analyzing glucose monitoring data indicative of a glucose level in a bodily fluid, and a computer program product |
US11441994B2 (en) * | 2017-07-27 | 2022-09-13 | Tata Consultancy Services Limited | Method and system for in-silico design of skin electroporation |
JP2020529606A (en) * | 2017-08-03 | 2020-10-08 | フィブロテックス エー | Lateral flow analysis and equipment for application to skin care |
CN109157280A (en) * | 2018-08-10 | 2019-01-08 | 重庆大学 | Irreversible electroporated tissue ablation effect dynamic realtime assessment equipment |
US20220257303A1 (en) * | 2019-06-28 | 2022-08-18 | Passport Technologies, Inc. | Methods and systems for controlling energy delivery to filament devices |
TWI723732B (en) * | 2019-08-02 | 2021-04-01 | 華廣生技股份有限公司 | Biosensor implantation device and implantation method |
CN110613893A (en) * | 2019-10-31 | 2019-12-27 | 南京工业职业技术学院 | Novel excitation coil |
CN111693434B (en) * | 2020-06-19 | 2024-01-19 | 中建路桥集团有限公司 | Experimental device for test concrete impervious performance |
CN114504373A (en) * | 2020-11-16 | 2022-05-17 | 澳美力科技(成都)有限公司 | Novel radio frequency conversion beauty instrument |
CN112957124B (en) * | 2021-01-30 | 2023-08-22 | 南京理工大学 | In-vitro laser biological tissue welding and sewing method for energy targeting regulation and control |
CN115670642A (en) * | 2021-05-20 | 2023-02-03 | 黄虹凤 | Laser wire cutting device capable of ensuring high precision and high speed |
CN114343839A (en) * | 2021-12-30 | 2022-04-15 | 德州环球之光医疗科技有限公司 | Treatment pattern conversion method based on adjustable spiral line type laser spots |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775361A (en) * | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
JP2798459B2 (en) * | 1988-01-21 | 1998-09-17 | マサチユセツツ・インスチチユート・オブ・テクノロジー | Diagnostic device using electroporation and device for moving molecules into tissue |
US5139023A (en) * | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
US5016615A (en) * | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
US5115805A (en) * | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
GB9014307D0 (en) * | 1990-06-27 | 1990-08-15 | Scient Generics Ltd | Method of treatment and compositions therefor |
JP3189337B2 (en) * | 1991-11-08 | 2001-07-16 | 日本電気株式会社 | Skin stratum corneum removal device and method |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
US5165418B1 (en) * | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
US5246437A (en) * | 1992-04-10 | 1993-09-21 | Abela George S | Cell treatment apparatus and method |
US5643252A (en) * | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US5279552A (en) * | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
US5267985A (en) * | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
US5582184A (en) * | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5445611A (en) * | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
AU725269B2 (en) * | 1995-07-25 | 2000-10-12 | Massachusetts Institute Of Technology | Enhanced transdermal transport using ultrasound |
-
1996
- 1996-08-29 AU AU68631/96A patent/AU707065B2/en not_active Expired
- 1996-08-29 CN CNB961966718A patent/CN1174713C/en not_active Expired - Lifetime
- 1996-08-29 GB GB9702766A patent/GB2307414B/en not_active Expired - Lifetime
- 1996-08-29 PT PT50110022T patent/PT1563788E/en unknown
- 1996-08-29 BR BR9610012-5A patent/BR9610012A/en not_active Application Discontinuation
- 1996-08-29 ES ES05011002.2T patent/ES2536459T3/en not_active Expired - Lifetime
- 1996-08-29 TR TR1998/00347T patent/TR199800347T1/en unknown
- 1996-08-29 EP EP96929098A patent/EP0858285A4/en not_active Withdrawn
- 1996-08-29 WO PCT/US1996/013865 patent/WO1997007734A1/en not_active Application Discontinuation
- 1996-08-29 IL IL12337996A patent/IL123379A/en not_active IP Right Cessation
- 1996-08-29 CA CA002199002A patent/CA2199002C/en not_active Expired - Lifetime
- 1996-08-29 JP JP51055297A patent/JP3899427B2/en not_active Expired - Lifetime
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1998
- 1998-02-27 NO NO19980878A patent/NO334437B1/en not_active IP Right Cessation
- 1998-08-24 HK HK98110113A patent/HK1009321A1/en not_active IP Right Cessation
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2006
- 2006-02-15 JP JP2006038655A patent/JP2006192285A/en not_active Withdrawn
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CN1174713C (en) | 2004-11-10 |
EP0858285A4 (en) | 2000-05-17 |
IL123379A (en) | 2002-04-21 |
HK1009321A1 (en) | 1999-05-28 |
PT1563788E (en) | 2015-06-02 |
CA2199002A1 (en) | 1997-03-01 |
ES2536459T3 (en) | 2015-05-25 |
GB2307414B (en) | 1998-03-11 |
CA2199002C (en) | 1999-02-23 |
NO980878L (en) | 1998-04-27 |
GB2307414A (en) | 1997-05-28 |
IL123379A0 (en) | 1998-09-24 |
JPH11511360A (en) | 1999-10-05 |
AU707065B2 (en) | 1999-07-01 |
JP3899427B2 (en) | 2007-03-28 |
EP0858285A1 (en) | 1998-08-19 |
CN1195276A (en) | 1998-10-07 |
WO1997007734A1 (en) | 1997-03-06 |
NO334437B1 (en) | 2014-03-03 |
AU6863196A (en) | 1997-03-19 |
NO980878D0 (en) | 1998-02-27 |
BR9610012A (en) | 1999-12-21 |
JP2006192285A (en) | 2006-07-27 |
GB9702766D0 (en) | 1997-04-02 |
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