SG11201900669WA - Engineered imine reductases and methods for the reductive amination of ketone and amine compounds - Google Patents
Engineered imine reductases and methods for the reductive amination of ketone and amine compoundsInfo
- Publication number
- SG11201900669WA SG11201900669WA SG11201900669WA SG11201900669WA SG11201900669WA SG 11201900669W A SG11201900669W A SG 11201900669WA SG 11201900669W A SG11201900669W A SG 11201900669WA SG 11201900669W A SG11201900669W A SG 11201900669WA SG 11201900669W A SG11201900669W A SG 11201900669WA
- Authority
- SG
- Singapore
- Prior art keywords
- california
- redwood city
- international
- penobscot
- drive
- Prior art date
Links
- -1 amine compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 108090000854 Oxidoreductases Proteins 0.000 title abstract 2
- 102000004316 Oxidoreductases Human genes 0.000 title abstract 2
- 108091007187 Reductases Proteins 0.000 title abstract 2
- 150000002466 imines Chemical class 0.000 title abstract 2
- 150000002576 ketones Chemical class 0.000 title abstract 2
- 238000006268 reductive amination reaction Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 240000005020 Acaciella glauca Species 0.000 abstract 3
- 235000003499 redwood Nutrition 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 108010031855 oxime reductase Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) o I iolo 011111 OM REHM IMO 011 (10) International Publication Number WO 2018/038906 Al WIPO I PCT (51) International Patent Classification: CO7H 21/00 (2006.01) C12N 9/06 (2006.01) C07K 14/435 (2006.01) Cl 2N 15/52 (2006.01) C12N 9/00 (2006.01) C12N 15/53 (2006.01) (21) International Application Number: PCT/US2017/045838 (22) International Filing Date: 08 August 2017 (08.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/380,165 26 August 2016 (26.08.2016) US (71) Applicant: CODEXIS, INC. [US/US]; 200 Penobscot Dri- ve, Redwood City, California 94063 (US). (72) Inventors: BORRA-GARSKE, Margie, Tabuga; 200 Penobscot Drive, Redwood City, California 94063 (US). ALVIZO, Oscar; 200 Penobscot Drive, Redwood City, California 94063 (US). MAYO, Melissa, Ann; 200 Penob- scot Drive, Redwood City, California 94063 (US). JENNE, Stephan; 200 Penobscot Drive, Redwood City, California 94063 (US). SOWELL-KANTZ, Auric, Anthony; 200 Penobscot Drive, Redwood City, California 94063 (US). MOLINARO, Carmela; 126 East Lincoln Avenue, Rah- way, New Jersey 07065 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (74) Agent: MACKNIGHT, Kamrin, T.; Codexis, Inc., 200 Penobscot Drive, Redwood City, California 94063 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, O GC Cr) O (54) Title: ENGINEERED MINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 0 (57) : The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides N encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engi- C neered polypeptides with a range of ketone amine substrate compounds to prepare secondary and tertiary amine product compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662380165P | 2016-08-26 | 2016-08-26 | |
PCT/US2017/045838 WO2018038906A1 (en) | 2016-08-26 | 2017-08-08 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201900669WA true SG11201900669WA (en) | 2019-03-28 |
Family
ID=61245145
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201900669WA SG11201900669WA (en) | 2016-08-26 | 2017-08-08 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
SG10202111589RA SG10202111589RA (en) | 2016-08-26 | 2017-08-08 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202111589RA SG10202111589RA (en) | 2016-08-26 | 2017-08-08 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
Country Status (8)
Country | Link |
---|---|
US (2) | US11046936B2 (en) |
EP (2) | EP3515926B1 (en) |
JP (2) | JP7316662B2 (en) |
CN (1) | CN109863162B (en) |
CA (1) | CA3032519A1 (en) |
IL (1) | IL264686B1 (en) |
SG (2) | SG11201900669WA (en) |
WO (1) | WO2018038906A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11046936B2 (en) * | 2016-08-26 | 2021-06-29 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
WO2020223102A1 (en) * | 2019-05-01 | 2020-11-05 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
CN110819601B (en) * | 2019-11-04 | 2021-07-20 | 江南大学 | Reductive amination enzyme, coding gene, recombinant vector, recombinant cell and application thereof |
CN114317472B (en) * | 2021-12-31 | 2022-07-05 | 长兴制药股份有限公司 | High stereoselectivity imine reductase and preparation method and application thereof |
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-
2017
- 2017-08-08 US US16/319,537 patent/US11046936B2/en active Active
- 2017-08-08 CN CN201780065554.1A patent/CN109863162B/en active Active
- 2017-08-08 CA CA3032519A patent/CA3032519A1/en active Pending
- 2017-08-08 IL IL264686A patent/IL264686B1/en unknown
- 2017-08-08 WO PCT/US2017/045838 patent/WO2018038906A1/en unknown
- 2017-08-08 EP EP17844113.5A patent/EP3515926B1/en active Active
- 2017-08-08 SG SG11201900669WA patent/SG11201900669WA/en unknown
- 2017-08-08 JP JP2019510842A patent/JP7316662B2/en active Active
- 2017-08-08 EP EP22208113.5A patent/EP4223766A3/en active Pending
- 2017-08-08 SG SG10202111589RA patent/SG10202111589RA/en unknown
-
2021
- 2021-05-26 US US17/330,686 patent/US11987818B2/en active Active
-
2022
- 2022-02-15 JP JP2022021157A patent/JP2022065092A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP4223766A2 (en) | 2023-08-09 |
SG10202111589RA (en) | 2021-11-29 |
US20200208123A1 (en) | 2020-07-02 |
EP4223766A3 (en) | 2023-10-18 |
CN109863162B (en) | 2023-03-17 |
IL264686A (en) | 2019-04-30 |
JP2022065092A (en) | 2022-04-26 |
EP3515926B1 (en) | 2023-10-25 |
WO2018038906A1 (en) | 2018-03-01 |
US11046936B2 (en) | 2021-06-29 |
US20210284973A1 (en) | 2021-09-16 |
CN109863162A (en) | 2019-06-07 |
JP7316662B2 (en) | 2023-07-28 |
CA3032519A1 (en) | 2018-03-01 |
EP3515926A1 (en) | 2019-07-31 |
JP2019526252A (en) | 2019-09-19 |
US11987818B2 (en) | 2024-05-21 |
IL264686B1 (en) | 2024-03-01 |
EP3515926A4 (en) | 2020-04-22 |
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