SG10202111589RA - Engineered imine reductases and methods for the reductive amination of ketone and amine compounds - Google Patents

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Info

Publication number
SG10202111589RA
SG10202111589RA SG10202111589RA SG10202111589RA SG10202111589RA SG 10202111589R A SG10202111589R A SG 10202111589RA SG 10202111589R A SG10202111589R A SG 10202111589RA SG 10202111589R A SG10202111589R A SG 10202111589RA SG 10202111589R A SG10202111589R A SG 10202111589RA
Authority
SG
Singapore
Prior art keywords
ketone
methods
amine compounds
reductive amination
engineered imine
Prior art date
Application number
SG10202111589RA
Inventor
Margie Borra-Garske
Oscar Alvizo
Melissa Mayo
Stephan Jenne
Auric Sowell-Kantz
Carmela Molinaro
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG10202111589RA publication Critical patent/SG10202111589RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
SG10202111589RA 2016-08-26 2017-08-08 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds SG10202111589RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662380165P 2016-08-26 2016-08-26

Publications (1)

Publication Number Publication Date
SG10202111589RA true SG10202111589RA (en) 2021-11-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202111589RA SG10202111589RA (en) 2016-08-26 2017-08-08 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG11201900669WA SG11201900669WA (en) 2016-08-26 2017-08-08 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201900669WA SG11201900669WA (en) 2016-08-26 2017-08-08 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Country Status (8)

Country Link
US (2) US11046936B2 (en)
EP (2) EP3515926B1 (en)
JP (2) JP7316662B2 (en)
CN (1) CN109863162B (en)
CA (1) CA3032519A1 (en)
IL (1) IL264686B1 (en)
SG (2) SG10202111589RA (en)
WO (1) WO2018038906A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7316662B2 (en) * 2016-08-26 2023-07-28 コデクシス， インコーポレイテッド Engineered imine reductases and methods for reductive amination of ketone and amine compounds
SG11202110852RA (en) * 2019-05-01 2021-10-28 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN110819601B (en) * 2019-11-04 2021-07-20 江南大学 Reductive amination enzyme, coding gene, recombinant vector, recombinant cell and application thereof
CN114317472B (en) * 2021-12-31 2022-07-05 长兴制药股份有限公司 High stereoselectivity imine reductase and preparation method and application thereof

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Also Published As

Publication number Publication date
WO2018038906A1 (en) 2018-03-01
EP3515926A1 (en) 2019-07-31
CA3032519A1 (en) 2018-03-01
SG11201900669WA (en) 2019-03-28
US20200208123A1 (en) 2020-07-02
EP3515926A4 (en) 2020-04-22
JP2022065092A (en) 2022-04-26
CN109863162A (en) 2019-06-07
EP3515926B1 (en) 2023-10-25
JP7316662B2 (en) 2023-07-28
IL264686B1 (en) 2024-03-01
US20210284973A1 (en) 2021-09-16
EP4223766A2 (en) 2023-08-09
CN109863162B (en) 2023-03-17
JP2019526252A (en) 2019-09-19
IL264686A (en) 2019-04-30
US11046936B2 (en) 2021-06-29
EP4223766A3 (en) 2023-10-18

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