RU2364389C1 - Mouth wash product - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to dentistry, namely to dental preparations, oral cavity and mouth wash products. A mouth wash product is intended for the patients after orthodontic therapy implying application of removable and fixed orthodontics. The product contains glycerine, crystal tea ledum tincture, common periwinkle tincture, coltsfoot tincture, peppermint tincture and tiller tincture, aspartame, biologically active additive "Litovit" in specific ratio.

EFFECT: mouth wash product possesses apparent cleaning effect, remineralising, anticariogenic, deintoxicating, antibacterial and deodorising activity.

1 ex, 1 tbl

Description

The invention relates to dentistry, namely to means for the care of teeth, oral cavity and mouthwash.

A number of oral care products are known in the art: “Vita”, “Eucalyptus”, “Enzyme-1”, “Remodent”, “Olympic”, “Lugovoi”, “Nikolaevsky”, “Flower”, “Mint”, “Lemon”, “Cetavlon”, “Coniferous”, “Ideal” [1].

These compounds are recommended as hygiene products for the prevention of dental caries and periodontal disease. They are used as mouth rinses.

A common disadvantage of all these oral hygiene products is that they are not intended for cleaning teeth whose surfaces are hidden under fixed and removable orthodontic structures. In addition, part of them contains ethyl alcohol, which has an irritating effect, part - abrasive substances, the use of which can lead to abrasion of tooth enamel, which will increase its permeability and will contribute to the development of caries. Therefore, their use is extremely ineffective in all categories of orthodontic patients.

As the closest in technical essence of the tool selected "Means for rinsing the oral cavity for the elderly and senile" (RU 2295967 C1, 11/14/2005). This product based on herbal components is intended for rinsing the oral cavity of elderly and senile people using removable dentures. The tool has anti-inflammatory, antibacterial, wound healing, hemostatic and salivary fluid action while maintaining the natural microflora of the oral cavity [2].

The disadvantage of this tool is the lack of remineralizing and anti-caries effects, which is extremely important in patients of any age, and especially in children and adolescents using fixed and removable orthodontic structures. In addition, a long stay in the oral cavity in patients of a foreign body (fixed orthodontic apparatus) based on alloys of metals and acrylic plastics leads to constant intoxication of the body, which negatively affects the immune status of the human body.

The task was: to develop the composition of an oral rinse based on plant components in patients with fixed and removable orthodontic structures, which has a cleansing, remineralizing, anti-carious, detoxifying, antibacterial and deodorizing effect.

The problem is solved by introducing into the composition of the mouth rinse containing polyhydric alcohol, components of medicinal plants, sweetener, biologically active additive (BAA) and drinking water, as polyhydric alcohol - glycerol, infusion of marsh rosemary, small periwinkle, mother and - stepmothers, peppermint and linden heart-shaped, aspartame as a sweetener, biologically active additives - “Litovit”, in the following ratio of components, wt.%:

Polyhydric alcohol 15-20 Infusion of marsh rosemary 4-6 Infusion of periwinkle small 2-4 Coltsfoot infusion 3-6 Peppermint Infusion 3-6 Heart-shaped linden infusion 4-6 Aspartame 1-2 BAA "Litovit" 0.05-0.1 Drinking water rest

The parameters of the components introduced into the composition of the agent were determined empirically. The introduction of components below the lower or higher than the upper limit does not provide optimal effects, and also worsens the presentation of the product. Characterization of the components of the mouthwash.

Polyhydric alcohol (glycerin) has a stabilizing effect, softens and fixes the composition. Infusion of marsh rosemary has a bactericidal and salivary fluid effect, a small periwinkle - increases the resistance of capillaries, has an antimicrobial effect, peppermint - an antiseptic, refreshing effect, linden cordate - a bactericidal, antimicrobial and refreshing effect, increases salivation, coltsfoot - act. The leaves of coltsfoot have anti-inflammatory and saliva-thinning properties, while stimulating the production of saliva by large salivary glands, i.e. provide increased flushing of plaque from the surface of the tooth enamel.

Infusions included in the composition of the mouth rinse were obtained as follows. Each of the selected plant components was taken in the required amount, crushed and insisted on a boiling water bath for 1 hour, then cooled, filtered and brought with hot water to the required volume.

A common property of all selected plant components of the claimed means for rinsing the oral cavity is a pronounced concentration of molybdenum, which is a trace element that impedes the development of dental caries due to the effect on the kinetics of enamel mineralization and the retention of fluoride ions.

The aspartame sweetener does not have a cariogenic effect, it does not undergo metabolic cleavage with the formation of acids by the microflora of the oral cavity, but it has a greater specific sweetness than sucrose, which makes it possible to use it not only in children, but also in patients with diseases of the pancreas and lymphoid system.

BAA - in the form of the biologically active additive “Litovit” prevents the activation of lipid peroxidation processes and, as a result, the shift of equilibrium towards prooxidant forms, helps to increase the buffer power of the oral defense systems, including neurohumoral mechanisms, and prevents the oxidative destruction of cell biomembranes and oral tissues . Dietary supplement “Litovit” (based on zeolites from the Kholinsky deposit) has a detoxifying, remineralizing and immunostimulating effect. In addition to the sorption action that relieves the body of toxins, “Litovit” has an activating effect on lymphoid cells due to absorption through the mucous membrane of the oral cavity of the biologically active components contained in it [3].

The proposed tool for rinsing the oral cavity has a multidirectional effect: it increases the mineralization level of tooth enamel, increases the remineralizing ability of saliva, increases salivation, prevents the formation of plaque and plaque, has a detoxifying and antibacterial effect. Such a complex effect is achieved due to a certain ratio of input components.

Means for rinsing the oral cavity is a homogeneous transparent liquid of light yellow color with a pleasant linden and mint smell and a fresh taste with a pH of 6.5-7.4.

The tool is used as follows: 40-50 drops per glass of warm water. Rinse intensively for 2-3 minutes after each meal, brushing your teeth in the morning and evening. Depending on the clinical situation, it is possible to use a double dose of the drug.

A method of preparing an oral rinse.

Example 1. The number of components is given per 100 kg of the finished product.

A mixture of 15 kg of glycerol (polyhydric alcohol) and infusions of marsh rosemary (4 kg), periwinkle (2 kg), coltsfoot (3 kg), peppermint (3 kg), and heart-shaped linden (4 kg) are separately prepared. , stirred at room temperature, then drinking water (25 kg) was added and the mixture was thoroughly mixed until completely dissolved.

The resulting mixture is poured into the reactor, aspartame (1 kg), Litovit (0.05 kg) are successively added to it. After loading all the components, the remaining water is added, stirred at room temperature for 60 minutes. The resulting liquid is sedimented for 12 hours, then filtered and served on packaging.

Example 2. Composition, kg:

Polyhydric alcohol twenty Infusion of marsh rosemary 6 Infusion of periwinkle small four Coltsfoot infusion 6 Peppermint Infusion 6 Heart-shaped linden infusion 6 Aspartame 2 BAA "Litovit" 0.1 Drinking water rest

The method of preparation of the rinse example 2 is similar to example 1.

Table 1
physicochemical and organoleptic characteristics of the composition of the inventive elixir are presented Component The content of components, wt.% According to the example: Example 1 Example 2 Polyhydric alcohol fifteen twenty Infusion of marsh rosemary four 6 Infusion of periwinkle small 2 four Infusion of coltsfoot leaves 3 6 Peppermint Infusion 3 6 Heart-shaped linden infusion four 6 Aspartame one 2 BAA "Litovit" 0.05 0.1 Drinking water Rest Indicator Appearance Homogeneous clear liquid Color light yellow yellow Smell Lime, mint Taste pleasant, fresh PH value 6.5 7.4

From the above examples and the data of table 1 it can be seen that the performance of the claimed means for rinsing the oral cavity correspond to GOST R 51577-2000 "Liquid hygiene products. General technical conditions "and the requirements of TU 10-04-16-108-88" Means for rinsing the oral cavity. Technical conditions. " In terms of consumer properties and effectiveness, the claimed tool surpasses the well-known prototype.

The shelf life of the finished product is 1 year. Storage conditions (correspond to GOST 27429): storage temperature - not lower than + 5 ° С and not higher than + 25 ° С in covered storage rooms in the manufacturer’s packaging.

The oral rinse according to example 1 can be used in children and adolescents undergoing orthodontic treatment with removable retention devices (plates, functional devices, Hawley removable standard retainers) with a CPU index of 0-2.5 (low prevalence and intensity of dental caries) , for example 2 - in adults, children and adolescents undergoing treatment with fixed orthodontic structures (fixed retainers, lingual arches of various designs, inter-canal glued retainers made of twisted wire oki) CPU with> 3.5 and higher (average and high intensity and prevalence of dental caries).

Good compatibility of these components with known medicinal properties ensures a synergy of their action, leading to the emergence of new properties and a wide range of pharmacological effects. The inventive means for rinsing the oral cavity prevents the attachment of dental plaque to the surface of the tooth enamel, increases the flushing, cleansing, remineralizing abilities of saliva, has a pronounced detoxification, antimicrobial, anti-carious, remineralizing and deodorizing effect while maintaining the natural microflora of the oral cavity. Such a complex effect is achieved due to the ratio of the introduced components defined in the claimed composition.

Examples of specific performance.

For a comparative assessment of the effectiveness of the developed composition of the elixir, it was used together with the prototype in 109 children aged 6 to 12 years and 54 adult patients undergoing treatment using removable and fixed orthodontic structures. The first group (59 children and 26 adults) used the claimed drug for 3 months, the second group (50 children and 28 adults) used the prototype during the same period of time. The value of the KPU index before treatment in all subjects was, on average, 3.4-4 points (average level of dental caries). Assessment of the hygienic state of the oral cavity was also carried out using the hygiene index (IG). The oral hygiene index was evaluated as follows: 1.1-1.4 points - good care (optimal); 1.5-1.8 - satisfactory; 1.9-2.5 - unsatisfactory; 2.6-3.8 - bad; 3.9-5 - very bad. A hygiene index of 2.6 or more points indicated a lack of regular oral care. Normally, the hygiene index does not exceed 1.1-1.5 points. A qualitative assessment of oral hygiene was carried out according to the following system: intensive staining of the tooth surface - 3 points, weak - 2, absent - 1 point. Normally, the indicator is 1.1-1.5 points. To study the solubility of enamel, a CRT test was used. After the study, a course of preventive use of the claimed dental elixir and prototype was prescribed. The CRT test indicator normally ranges from 20 to 120 s. The plaque index was determined using a plaque index according to Silness-Lo (1964) and the Rumfjord Hygiene Index (1956). Functional enamel resistance to acid was determined using the TER test (V.R. Okushko, L.I. Kosareva, 1983). It is used for the initial determination of acid resistance of tooth enamel and for an objective assessment of the effectiveness of remineralizing therapy during follow-up and treatment of patients. This test allows you to evaluate the growth of caries by the degree of acid resistance (functional resistance) of the enamel, in accordance with the level of remineralization and enamel resistance to acid, high tooth resistance to caries was noted as 1-3 points (pale blue), average - 4-6 points ( blue color), low - 7-9 points (blue color), extremely low - 10-12 points (dark blue color). At the time of the start of the study, the TER test indicators in both groups of children and adults ranged from 6.5 to 11-12 points on average — reduced and extremely low structural and functional enamel resistance, high and maximum risk of caries.

As the results of the study showed, in the control group (prototype) there was no significant decrease in the intensity of caries, the value of the KPU index remained at a level slightly lower than the initial one - 2.9-3.6 points. The CRT test showed an average level of resistance of tooth enamel after the course of treatment (115-135 s). The TER test showed an average and low structural and functional resistance of enamel, an average and high risk of caries (3.5-7.5 points). The hygiene index indicator averaged 2.3 points (unsatisfactory level). In the main group of the study (the claimed tool) there was no increase in caries for 3 months of using the drug, on the contrary, there was a decrease in the constant “K” indicator by 39.4% in the structure of the KPU index compared to the initial indicators. The average value of the KPU index was 1.7-2.2 points. The CRT test showed a high level of resistance of tooth enamel after the course of treatment (45-75 s). The average values of the TER test showed a high structural and functional resistance of the enamel and high resistance of the teeth to caries (1-2.5 points) after the course of treatment. The index of hygiene was, on average, 1.2-1.3 points (optimal and satisfactory level).

Thus, the developed tool for rinsing the oral cavity in patients with fixed and removable orthodontic structures, showed higher efficiency than the known prototype, the use of the claimed means prevents the formation of plaque and plaque, the elixir has a pronounced cleansing, remineralizing, anti-carious, detoxification, antibacterial and deodorizing effect. The production of the product is possible using the most affordable, inexpensive components and a fairly simple technology that allows you to effectively use the claimed tool for rinsing the oral cavity in all categories of patients with retention of dentition undergoing treatment using fixed and removable orthodontic structures.

INFORMATION SOURCES

1. Yakovleva V.I., Trofimova E.K., Davidovich T.P., Prosviryak G.P. Diagnosis, treatment and prevention of dental diseases // Minsk, Izd. Higher School, 1994, p. 471.

2. Patent RU 2295967 C1, 11/14/2005.

3. Borodin Yu.I., Gorchakov VN, Bgatova NP, et al. Morphofunctional assessment of the impact of biologically active additives "Litovit" on the organs and systems of the body. - Novosibirsk, Publishing House Ecor - 2000, 78 p.

Claims (1)

Oral rinse for patients with fixed and removable orthodontic constructions, characterized in that it contains infusions of marsh rosemary, periwinkle, coltsfoot, peppermint and linden cordate, aspartame, glycerin, dietary supplement (BAA) " Litovit ”and drinking water in the following ratio of components, wt.%:
infusion of Ledum marsh 4-6 infusion of periwinkle small 2-4 coltsfoot infusion 3-6 peppermint infusion 3-6 heart-shaped linden infusion 4-6 aspartame 1-2 glycerol 15-20 BAA "Litovit" 0.05-0.1 drinking water rest