RU2355380C1 - Dentifrice water for prevention and treatment of initial caries - Google Patents

Abstract

FIELD: medicine; dentistry.

SUBSTANCE: dentifrice water for prevention and treatment of initial caries containing glycerine, ethyl alcohol, sodium fluoride, calcium hydroxyapatite, desorbent pectin, extract of coltsfoot leaves, bay laurel leaves, essence of peppermint, blackbutt and distilled water in certain ratio.

EFFECT: dentifrice water prevents dental deposit and dental plaque, possesses remineralising, effective anticarious, cleaning and deodorising action.

1 tbl, 2 ex

Description

The invention relates to dentistry, namely to means for the care of teeth, oral cavity and mouthwash.

It is known from the prior art that for the prevention and remineralizing therapy of the initial forms of caries, 10% calcium gluconate solution, 2-10% acidified calcium phosphate solutions, as well as preparations containing a complex of macro- and microelements with anti-carious effects are used. The well-known drug "Remodent", consisting of calcium - 4.35 g, magnesium - 0.15 g, potassium - 0.20 g, sodium - 16 g, chlorine - 30 g, organic substances - 44.5 g, the rest is up to 100 g, produced in the form of a white amorphous powder, from which 2.5-3% solutions are prepared [1].

These substances are used in the form of applications and introduced into the hard tissues of the tooth by electrophoresis. After electrophoresis or application, cotton swabs moistened with 1-2% sodium fluoride solution are applied to the treated teeth for 2-3 minutes. This contributes to the fixation of calcium salts in the tissues of the tooth.

The disadvantage of this drug is the mandatory use of physical methods (electrophoresis) for the deposition of drugs in the hard tissues of the tooth. Such a condition sharply increases the level of costs and reduces the availability of the procedure as part of the implementation of the program for the prevention of dental caries in the population. The use of various fluorides, polymerization varnishes and films for the same purpose also requires specialized dental care, which should be carried out only in a dental office.

Known drug "Vitaftor" containing in 1 ml of sodium fluoride 22 mg, retinol palmitate 0.36 mg, ergocalciferol 0.002 mg, ascorbic acid 12 mg with the addition of sorbitol and other substances [2]. The drug is prescribed for children inside in the complex of therapeutic and preventive care for dental caries and to improve the formation of tissues of permanent teeth.

The disadvantage of this tool is a weak remineralizing and anticariogenic effect, as well as the possibility of the occurrence of A - and D - hypervitaminosis with prolonged use of the drug. In addition, the use of the drug "Vitaftor", as well as "Remodent", should be carried out individually, as part of a special course of treatment that requires strict adherence to the regimen of use of these funds.

For mass prophylaxis of the initial forms of dental caries, along with training in oral hygiene and the use of fluoride-containing toothpastes, the use of fluoride-containing tooth elixirs and rinses, which are recommended for children after meals, is most suitable. Children in preschool institutions and elementary grades of secondary schools use dental elixirs under the control of parents, educators and teachers, in the future - on their own.

Known dental elixir "Radiant" (prototype), containing sodium glycerophosphate - 1.8-2%, dehmitsida - 0.12-0.5, potassium fluoride - 1.8-2, glycerol - 4-5, menthol - 0, 02-0.1, perfumes - 0.5-1.5, dye - 0.01-0.02, alcohol - 50, water - up to 100% [1]. It is used to rinse the oral cavity 3 times a day after meals for 3 months. A dental elixir is highly effective as a remineralizing agent for hard tissue of teeth.

The disadvantage of this elixir is that it does not contain substances that reduce the intensity of plaque formation and fixation of tooth plaque to tooth enamel, which, as you know, serves as a place of maximum concentration or a compress for microorganisms and acids produced by microorganisms that destroy, “demineralize »Tooth enamel.

The task is to develop a dental elixir for the prevention and treatment of initial forms of dental caries, which prevents the formation of plaque and plaque, which has remineralizing, anti-carious, cleansing and deodorizing effects, suitable for use in the mass program for the prevention of dental caries.

The problem is solved by including in the composition of the tooth elixir containing polyhydric alcohol, ethyl alcohol, mineralizer, desorbent, sodium fluoride, plant extracts, essential oils and distilled water, polyhydric alcohol - glycerol, ethyl alcohol, mineralizer - calcium hydroxyapatite, desorbent - pectin , sodium fluoride, coltsfoot leaf extract, noble laurel, peppermint essential oil, ball eucalyptus, distilled water in the following ratio, wt.%:

Polyhydric alcohol 6-10 Ethanol 25-30 Calcium Hydroxyapatite 2-4 Sodium fluoride 0.001-0.005 Pectin 0.1-0.5 Coltsfoot Leaf Extract 4-8 Noble Laurel Leaf Extract 4-8 Peppermint essential oil 0.05-0.1 Ball Eucalyptus Essential Oil 0.05-0.1 Distilled water rest

The parameters of the components introduced into the composition of the tooth elixir were determined empirically. The introduction of components below the lower or higher than the upper limit does not provide optimal exposure, and also worsens the presentation of the elixir.

Characterization of the components of the tooth elixir.

Polyhydric alcohol (glycerin) has a stabilizing effect, softens and fixes the composition. Ethyl alcohol acts as a preservative and solvent.

Calcium hydroxyapatite - a mineralizer, replenishes the nutritional deficiency of a growing crystal; contains ions that can be incorporated into apatite isomorphically; contributes to a change in the kinetics of mineralization of tooth enamel. Sodium fluoride affects the kinetics of mineralization, prevents the adsorption of organic substances and microorganisms on the enamel surface, participates in the construction of enamel prisms, fixes the edges of the growing crystal, and neutralizes acids. Pectin is an active desorbent, prevents the adsorption of organic substances and microorganisms on the enamel surface, has the ability to reduce by 50% the adhesion of bacteria to the enamel surface and the formation of dental plaque.

The leaves of coltsfoot have anti-inflammatory, antibacterial and saliva-thinning properties, while stimulating the production of saliva by large salivary glands, i.e. provide increased flushing of plaque from the surface of the tooth enamel. The leaves of the noble laurel have a sugar-lowering property [3], help regulate carbohydrate metabolism, and inhibit the aggressive properties of soft dental deposits.

Peppermint essential oil mediates an antiseptic, refreshing effect, when rinsing forms a hydrophobic film coating on the teeth that prevents the appearance of plaque. Ball eucalyptus essential oil also forms a hydrophobic film coating on the teeth that prevents the appearance of plaque, has an antimicrobial and bactericidal effect, has a pleasant and persistent odor.

The proposed dental elixir has a multidirectional effect: it increases the mineralization level of tooth enamel, increases the remineralizing ability of saliva, increases salivation, prevents the formation of plaque and plaque, has a hypoglycemic, antimicrobial and effective anticariogenic effect. Such a complex effect is achieved due to a certain ratio of input components.

The tooth elixir is a homogeneous clear liquid of a light yellow color with a pleasant mint-eucalyptus odor and a fresh taste with a pH of 6.5-7.4.

The elixir is used as follows: 10-20 drops or 1 teaspoon in 1/3 cup of warm water. Rinse intensively for 3-5 minutes after each meal, brushing your teeth in the morning and evening. Depending on the clinical situation, it is possible to use a double dose of elixir.

A method of preparing a tooth elixir.

Example 1. The number of components is given per 1000 kg of the finished product.

A mixture of 60 kg of glycerol (polyhydric alcohol) and peppermint essential oil (0.5 kg) and ball eucalyptus (0.5 kg) is separately prepared, stirred at room temperature, then distilled water (50 kg) is added and the mixture is thoroughly mixed until complete dissolution. Then, 250 kg of ethyl alcohol, calcium hydroxyapatite (20 kg), coltsfoot leaf extracts (40 kg) and noble laurel leaves (40 kg), sodium fluoride (0.01 kg), pectin (1 kg) are successively poured into the reactor. )

Stirred and add the prepared mixture of glycerin with essential oils. After loading all the components, the remaining water is added, stirred at room temperature for 60 minutes. The resulting liquid is left to stand for 12 hours, then filtered and fed to packaging.

Example 2. Composition, kg:

Polyhydric alcohol 10 Ethanol thirty Calcium Hydroxyapatite four Sodium fluoride 0.05 Pectin 0.5 Coltsfoot Leaf Extract 8 Noble Laurel Leaf Extract 8 Peppermint essential oil one Ball Eucalyptus Essential Oil one Distilled water rest

The method of preparation of the dental elixir of example 2 is similar to example 1.

Table 1 presents the physico-chemical and organoleptic characteristics of the composition of the inventive elixir.

Component The content of components, wt.% According to the example Example 1 Example 2 Polyhydric alcohol 8 10 Ethanol 25 thirty Calcium Hydroxyapatite 2 four Sodium fluoride 0.001 0.005 Pectin 0.1 0.5 Coltsfoot Leaf Extract four 8 Noble Laurel Leaf Extract four 8 Peppermint essential oil 0.05 0.1 Ball Eucalyptus Essential Oil 0.05 0.1 Distilled water Rest Indicator Appearance Homogeneous clear liquid Color light yellow yellow Smell mint eucalyptus Taste pleasant, fresh PH value 6.5 7.4 Fortress,% 42.5 47.8

From the above examples and the data of table 1 shows that the performance of the inventive dental elixir comply with GOST R 51577-2000 "Liquid oral hygiene products. General specifications "and the requirements of TU 10-04-16-108-88" Dental elixirs. Technical conditions. " In terms of consumer properties and effectiveness, the claimed dental elixir surpasses the well-known prototype.

The shelf life of the finished product (dental elixir) is set at 2 years. Storage conditions (correspond to GOST 27429): storage temperature - not lower than + 5 ° С and not higher than + 25 ° С in covered storage rooms in the manufacturer’s packaging.

The dental elixir according to example 1 can be used in children and adolescents with a KPU index of 0-2.5 (low prevalence and intensity of dental caries), as in example 2 - in children and adolescents with a KPU> 3.5 and above (medium and high prevalence and tooth decay rate).

Good compatibility of these components with known medicinal properties ensures a synergy of their action, leading to the emergence of new properties and a wide range of pharmacological effects. The inventive dental elixir prevents the attachment of dental plaque to the surface of the tooth enamel, increases the flushing, cleansing and remineralizing abilities of saliva, has a pronounced antimicrobial, anticariotic, remineralizing and deodorizing effects while maintaining the natural microflora of the oral cavity. Such a complex effect is achieved due to the ratio of the introduced components defined in the claimed composition of the elixir.

Examples of specific performance.

For a comparative assessment of the effectiveness of the developed composition of the elixir, it was used together with the prototype in 114 children aged 6 to 12 years. The first group of children (59 people) used the claimed elixir for 3 months, the second group (55 people) used the prototype during the same period of time. The value of the KPU index before treatment in all subjects was, on average, 3.4-4 points (average level of dental caries).

Assessment of the hygienic state of the oral cavity was also carried out using the hygiene index (IG). The oral hygiene index was evaluated as follows: 1.1-1.4 points - good care (optimal); 1.5-1.8 - satisfactory; 1.9-2.5 - unsatisfactory; 2.6-3.8 - bad; 3.9-5 - very bad. A hygiene index of 2.6 or more points indicated a lack of regular oral care. Normally, the hygiene index does not exceed 1.1 -1.5 points. A qualitative assessment of oral hygiene was carried out according to the following system: intensive staining of the tooth surface - 3 points, weak - 2, absent - 1 point. Normally, the indicator is 1.1-1.5 points.

A CRT test was used to study the enamel solubility. A disk of filter paper 3 mm in diameter was placed on a dried and thoroughly cleaned of soft plaque tooth surface. Previously, the 30 s disk was impregnated with a 0.02% aqueous solution of crystal violet, staining it with a light green color. 1.5 μl of 1 N was applied to the disk with a micropipette. hydrochloric acid solution and using a stopwatch determined the time during which the color of the disk changed from light green to pink-purple. The color reaction time was used to judge the degree of enamel solubility, which is an indicator of its resistance.

After the study, a course of preventive use of the claimed dental elixir and prototype was prescribed. The CRT test indicator normally ranges from 20 to 120 s.

The plaque index was determined using the Silness-Loë plaque index (1964) and the Rumfjord Hygiene Index (1956).

The functional resistance of enamel to acid was determined using the TER test (V.R.Okushko, L.I. Kosareva, 1983). It is used for the initial determination of acid resistance of tooth enamel and for an objective assessment of the effectiveness of remineralizing therapy during follow-up and treatment of patients. The test is carried out as follows: a drop of 1 N is applied to the vestibular surface of the central upper incisor washed with distilled water and dried with a cotton swab. hydrochloric acid solution with a diameter of about 2 mm. After 5 seconds, the acid is washed off with distilled water and the tooth surface is dried with a cotton swab. Then it is stained with a 1% aqueous solution of methylene blue. The dye is removed from the enamel surface in one erasing motion, tightly pressing a cotton swab to the tooth surface. The color intensity corresponds to the depth of etching (roughness) of the enamel. The staining intensity is evaluated on a typographic ten- and twelve-point blue scale. This test allows you to evaluate the growth of caries by the degree of acid resistance (functional resistance) of the enamel, in accordance with the level of remineralization and enamel resistance to acid, high tooth resistance to caries was noted as 1-3 points (pale blue), average - 4-6 points ( blue color), low - 7-9 points (blue color), extremely low - 10-12 points (dark blue color).

At the time of the start of the study, the TER test indicators in both groups of children averaged from 7 to 12 points - low and extremely low structural and functional enamel resistance, high and maximum risk of caries.

As the results of the study showed, in the control group (prototype) there was no significant decrease in the intensity of caries, the value of the KPU index remained at a level slightly lower than the initial one - 2.9-3.6 points. The CRT test showed an average level of resistance of tooth enamel after the course of treatment (120-140 s). The TER test showed medium and low structural and functional enamel resistance, medium and high risk of caries (4-8 points). The hygiene index indicator averaged 2.2 points (unsatisfactory level).

In the main group of the study (the claimed dental elixir), there was no increase in caries for 3 months of using the drug, on the contrary, there was a decrease in the constant “K” by 35.8% in the structure of the KPU index compared to the initial indicators. The average value of the KPU index was 1.8-2.3 points. The CRT test showed a high level of resistance of tooth enamel after the course of treatment (40-80 s). The average values of the TER test showed a high structural and functional resistance of the enamel and high resistance of the teeth to caries (1-3 points) after the course of treatment. The hygiene index indicator averaged 1.3-1.5 points (optimal and satisfactory level).

Thus, the developed dental elixir for the prevention and treatment of initial forms of dental caries has shown higher efficiency than the known prototype, the use of the inventive tool prevents the formation of plaque and plaque, the elixir has a pronounced remineralizing, anti-carious, cleansing and deodorizing effects. The production of the elixir is possible using inexpensive components and a fairly simple technology that allows you to effectively use the inventive dental elixir in mass prevention programs for dental caries.

Information sources

Yakovleva V.I., Trofimova E.K., Davidovich T.P., Prosviryak G.P. Diagnosis, treatment and prevention of dental diseases. // Minsk: Higher School, 1994, p. 168, p. 170.

Mashkovsky M.D. Medicines In 2 volumes. T.2. - 10th ed. erased. - M.: Medicine, 1985 - p. 135.

Goncharova T.A. Encyclopedia of medicinal plants. Herbal treatment. In 2 volumes. - M.: Publishing. MSP House, 1999.V.1, p.346.

Claims (1)

Dental elixir for the prevention and treatment of initial forms of dental caries, containing glycerin, ethyl alcohol, extracts of plant materials, water, characterized in that it contains calcium-hydroxyapatite mineralizer, sodium fluoride, desorbent pectin, leaves of coltsfoot, laurel noble, essential oils of peppermint, ball eucalyptus and distilled water in the following ratio of components, wt.%:
glycerol 6-10 ethanol 25-30 calcium hydroxyapatite 2-4 sodium fluoride 0.001-0.005 pectin 0.1-0.5 coltsfoot leaf extract 4-8 noble laurel leaf extract 4-8 peppermint essential oil 0.05-0.1 ball eucalyptus essential oil 0.05-0.1 distilled water rest