PE20191245A1 - Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim - Google Patents

Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim

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Publication number
PE20191245A1
PE20191245A1 PE2019001262A PE2019001262A PE20191245A1 PE 20191245 A1 PE20191245 A1 PE 20191245A1 PE 2019001262 A PE2019001262 A PE 2019001262A PE 2019001262 A PE2019001262 A PE 2019001262A PE 20191245 A1 PE20191245 A1 PE 20191245A1
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PE
Peru
Prior art keywords
kinase inhibitors
thiazolcarboxamides
pyridinacarboxamide
pim kinase
halo
Prior art date
Application number
PE2019001262A
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English (en)
Inventor
Chu-Biao Xue
Yun-Long Li
Hao Feng
Jun Pan
Anlai Wang
Ke Zhang
Wenqing Yao
Fenglei Zhang
Jincong Zhuo
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of PE20191245A1 publication Critical patent/PE20191245A1/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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Abstract

Referido a un compuesto de formula II-8 o una sal farmaceuticamente aceptable de este, en donde n es 0, 1 o 2; k es 0, 1, 2 o 3; el anillo A de formula (A-1) o (A-2), en donde E1 y E2 son anillos fenilo, estando opcionalmente sustituidos por 1, 2 o 3 sustituyentes independientemente seleccionados de RE; G3 es N o CR3; R1 es H, F o NH2; R2 es H, halo o CN; R4 es H, F o NH2. Cada RB es halo, alquilo C1-6, haloalquilo C1-6, entre otros; cada RD es halo, alquenilo C2-6, alquinilo C2-6, entre otros. Un compuesto seleccionado es 5-amino-N-{4-[3-aminopiperidin-1-il]-2,3-dihidrofuro[2,3-b]piridin-5-il}-2-(2,6-difluorofenil)-1,3-tiazol-4-carboxamida. Estos compuestos tiazolcarboxamidas y piridinacarboxamida son utiles como inhibidores de quinasa PIM en el tratamiento del cancer.
PE2019001262A 2013-01-15 2014-01-14 Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim PE20191245A1 (es)

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US201361752897P 2013-01-15 2013-01-15
US201361790952P 2013-03-15 2013-03-15
US201361859118P 2013-07-26 2013-07-26

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