MX2009009304A - Inhibidores de cinasa pim y metodos para su uso. - Google Patents

Inhibidores de cinasa pim y metodos para su uso.

Info

Publication number
MX2009009304A
MX2009009304A MX2009009304A MX2009009304A MX2009009304A MX 2009009304 A MX2009009304 A MX 2009009304A MX 2009009304 A MX2009009304 A MX 2009009304A MX 2009009304 A MX2009009304 A MX 2009009304A MX 2009009304 A MX2009009304 A MX 2009009304A
Authority
MX
Mexico
Prior art keywords
methods
compositions
kinase
kinase inhibitors
pim kinase
Prior art date
Application number
MX2009009304A
Other languages
English (en)
Inventor
Jiong Lan
Christopher Mcbride
Cynthia Shafer
Matthew Burger
Annette Walter
Gordana Atallah
Mika Lindvall
Wooseok Han
Gisele Nishiguchi
Cornelia Bellamacina
Kay Huh
William Antonios-Mccrea Jr
Tatiana Zavorotinskaya
Pablo Garcia
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009009304A publication Critical patent/MX2009009304A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Abstract

Se proporcionan nuevos compuestos, composiciones, y métodos para la inhibición de la actividad de cinasa asociada con la tumorigénesis en un sujeto humano o animal. En ciertas modalidades, los compuestos y composiciones son efectivos para inhibir la actividad de cuando menos una cinasa de serina/treonina o cinasa de tirosina receptora. Los nuevos compuestos y composiciones se pueden utilizar ya sea solos o bien en combinación con cuando menos un agente adicional para el tratamiento de un trastorno mediado por cinasa de serina/treonina o por cinasa de tirosína receptora, tal como cáncer.
MX2009009304A 2007-03-01 2008-03-03 Inhibidores de cinasa pim y metodos para su uso. MX2009009304A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89244407P 2007-03-01 2007-03-01
US2377708P 2008-01-25 2008-01-25
PCT/US2008/055724 WO2008106692A1 (en) 2007-03-01 2008-03-03 Pim kinase inhibitors and methods of their use

Publications (1)

Publication Number Publication Date
MX2009009304A true MX2009009304A (es) 2009-11-18

Family

ID=39433847

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009304A MX2009009304A (es) 2007-03-01 2008-03-03 Inhibidores de cinasa pim y metodos para su uso.

Country Status (12)

Country Link
US (1) US8822497B2 (es)
EP (1) EP2132177B1 (es)
JP (1) JP5330274B2 (es)
KR (1) KR101514853B1 (es)
CN (1) CN101679266B (es)
AU (1) AU2008221263B2 (es)
BR (1) BRPI0808523A2 (es)
CA (1) CA2679659C (es)
EA (1) EA019951B1 (es)
ES (1) ES2431163T3 (es)
MX (1) MX2009009304A (es)
WO (1) WO2008106692A1 (es)

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CA2679659A1 (en) 2008-09-04
BRPI0808523A2 (pt) 2014-08-19
US8822497B2 (en) 2014-09-02
KR20100015331A (ko) 2010-02-12
WO2008106692B1 (en) 2008-10-30
AU2008221263A1 (en) 2008-09-04
EP2132177A1 (en) 2009-12-16
ES2431163T3 (es) 2013-11-25
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CA2679659C (en) 2016-01-19
CN101679266A (zh) 2010-03-24
JP2010520228A (ja) 2010-06-10
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