MX2021002574A - Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas. - Google Patents
Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas.Info
- Publication number
- MX2021002574A MX2021002574A MX2021002574A MX2021002574A MX2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A MX 2021002574 A MX2021002574 A MX 2021002574A
- Authority
- MX
- Mexico
- Prior art keywords
- mass spectrometry
- engineered cell
- methods
- cell composition
- profile
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 238000004949 mass spectrometry Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 abstract 7
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
Abstract
En la presente se proporcionan métodos para generar un perfil de espectrometría de masas (MS) de una muestra a partir de una composición de células, tal como una composición de células modificadas. En algunas modalidades, el perfil de espectrometría de masas incluye datos basados en uno o más análisis o técnicas de espectrometría de masas. En la presente también se proporcionan métodos para, con base en perfiles de espectrometría de masas de una o más muestras de estas composiciones de células: identificar un perfil de espectrometría de masas (MS) de una composición de células genéticamente modificadas que comprende células inmunitarias que comprenden un receptor recombinante por comparación a un perfil de espectrometría de masas de referencia; caracterizar un proceso para producir composición de células genéticamente modificadas; valorar proteínas de superficie celular de una composición de células modificadas; y valorar un proceso para producir una composición de células genéticamente modificadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862729985P | 2018-09-11 | 2018-09-11 | |
PCT/US2019/050681 WO2020056047A1 (en) | 2018-09-11 | 2019-09-11 | Methods for mass spectrometry analysis of engineered cell compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021002574A true MX2021002574A (es) | 2021-06-08 |
Family
ID=68136527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021002574A MX2021002574A (es) | 2018-09-11 | 2019-09-11 | Metodos para el analisis por espectrometria de masas de composiciones de celulas modificadas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220050114A1 (es) |
EP (1) | EP3850366A1 (es) |
JP (1) | JP2022500674A (es) |
KR (1) | KR20210081341A (es) |
CN (1) | CN113167796A (es) |
AU (1) | AU2019339464A1 (es) |
BR (1) | BR112021004261A2 (es) |
CA (1) | CA3111789A1 (es) |
EA (1) | EA202190693A1 (es) |
IL (1) | IL281325A (es) |
MA (1) | MA53612A (es) |
MX (1) | MX2021002574A (es) |
SG (1) | SG11202102108QA (es) |
WO (1) | WO2020056047A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019012189A (es) | 2017-04-14 | 2020-12-10 | Juno Therapeutics Inc | Metodos para valorar la glucosilacion de la superficie celular. |
EP4277917A2 (en) * | 2021-01-14 | 2023-11-22 | Biocatalyst LLC | Compositions and methods for peptide production |
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US10301370B2 (en) | 2014-05-02 | 2019-05-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor T cells |
KR102618267B1 (ko) | 2014-05-29 | 2023-12-27 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 항-인유두종바이러스 16 e7 t 세포 수용체 |
EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
AU2015343121B2 (en) | 2014-11-05 | 2020-06-18 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
EP3344263A4 (en) * | 2016-08-04 | 2020-07-01 | Memorial Sloan-Kettering Cancer Center | CANCER ANTIQUES AND USES THEREOF |
MX2019010171A (es) | 2017-02-27 | 2019-10-15 | Juno Therapeutics Inc | Composiciones, articulos de fabricacion y metodos relacionados con la dosificacion en la terapia celular. |
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2019
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- 2019-09-11 SG SG11202102108QA patent/SG11202102108QA/en unknown
- 2019-09-11 BR BR112021004261-0A patent/BR112021004261A2/pt unknown
- 2019-09-11 US US17/274,770 patent/US20220050114A1/en active Pending
- 2019-09-11 CN CN201980073541.8A patent/CN113167796A/zh active Pending
- 2019-09-11 EA EA202190693A patent/EA202190693A1/ru unknown
- 2019-09-11 MX MX2021002574A patent/MX2021002574A/es unknown
- 2019-09-11 CA CA3111789A patent/CA3111789A1/en active Pending
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2021
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MA53612A (fr) | 2021-09-15 |
EA202190693A1 (ru) | 2021-07-27 |
WO2020056047A1 (en) | 2020-03-19 |
JP2022500674A (ja) | 2022-01-04 |
EP3850366A1 (en) | 2021-07-21 |
KR20210081341A (ko) | 2021-07-01 |
AU2019339464A1 (en) | 2021-03-25 |
CA3111789A1 (en) | 2020-03-19 |
SG11202102108QA (en) | 2021-04-29 |
BR112021004261A2 (pt) | 2021-05-25 |
US20220050114A1 (en) | 2022-02-17 |
IL281325A (en) | 2021-04-29 |
CN113167796A (zh) | 2021-07-23 |
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