MX2020007960A - Methods of purifying cannabinoids using liquid:liquid chromatography. - Google Patents
Methods of purifying cannabinoids using liquid:liquid chromatography.Info
- Publication number
- MX2020007960A MX2020007960A MX2020007960A MX2020007960A MX2020007960A MX 2020007960 A MX2020007960 A MX 2020007960A MX 2020007960 A MX2020007960 A MX 2020007960A MX 2020007960 A MX2020007960 A MX 2020007960A MX 2020007960 A MX2020007960 A MX 2020007960A
- Authority
- MX
- Mexico
- Prior art keywords
- liquid
- cannabinoids
- methods
- chromatography
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
- C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present specification discloses methods of purifying one or more cannabinoids from a plant material using unique biphasic solvent systems and liquid-liquid chromatography as centrifugation partitioning chromatography (CPC) or counter current chromatography (CCC). The present specification also provides purified cannabinoids such as CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA and THCV, compositions comprising one or more of these cannabinoids produced by the disclosed method, and methods for treating a disease or condition employing such purified cannabinoids and compositions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/882,516 US10207198B2 (en) | 2015-01-22 | 2018-01-29 | Methods of purifying cannabinoids using liquid:liquid chromatography |
PCT/EP2019/052069 WO2019145552A1 (en) | 2018-01-29 | 2019-01-29 | Methods of purifying cannabinoids using liquid:liquid chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020007960A true MX2020007960A (en) | 2020-09-24 |
Family
ID=65276144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020007960A MX2020007960A (en) | 2018-01-29 | 2019-01-29 | Methods of purifying cannabinoids using liquid:liquid chromatography. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP3746419A1 (en) |
CN (1) | CN111788171A (en) |
AU (1) | AU2019211188A1 (en) |
CA (1) | CA3089490A1 (en) |
CL (1) | CL2020001964A1 (en) |
CO (1) | CO2020009747A2 (en) |
IL (1) | IL276010A (en) |
MX (1) | MX2020007960A (en) |
WO (1) | WO2019145552A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020252369A1 (en) * | 2019-06-14 | 2020-12-17 | Purisys Llc | Crystalline cannabigerol |
CN110590511B (en) * | 2019-09-11 | 2021-05-28 | 上海同田生物技术股份有限公司 | Method for simultaneously separating cannabidiol and cannabigerol |
CN112279752B (en) * | 2020-10-30 | 2022-11-11 | 云南芙雅生物科技有限公司 | Supercritical carbon dioxide extraction method of cannabinoids for industrial cannabis sativa |
CN113135885A (en) * | 2021-04-07 | 2021-07-20 | 上海同田生物技术有限公司 | Method for separating and purifying tetrahydrocannabinol by high-speed counter-current chromatography |
AU2022375771A1 (en) | 2021-10-26 | 2024-05-23 | Ecofibre USA Inc. | Methods of treating ovarian cancer with hemp extract |
US11857590B2 (en) * | 2021-10-26 | 2024-01-02 | Ecofibre Limited | Systems and methods for producing hemp extracts and compositions |
AU2022379618A1 (en) | 2021-10-26 | 2024-05-23 | Ecofibre USA Inc. | Methods of treating endometriosis and other non-cancer gynecological disorders with hemp extract |
CN115385780B (en) * | 2022-08-26 | 2024-02-27 | 晨光生物科技集团股份有限公司 | Secondary cannabidiol crystal polymorph and preparation method and application thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0166088B1 (en) | 1990-01-23 | 1999-01-15 | . | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
ES2305437T3 (en) * | 2002-02-01 | 2008-11-01 | Resolution Chemicals Limited | DELTA-9 TETRAHIDROCANNABINOL PRODUCTION. |
US20080103193A1 (en) * | 2006-10-26 | 2008-05-01 | Trevor Percival Castor | Methods for making compositions and compositions for treating pain and cachexia |
US10155708B2 (en) * | 2015-01-22 | 2018-12-18 | Phytoplant Research S.L. | Methods of purifying cannabinoids, compositions and kits thereof |
BR122019001241B1 (en) | 2015-01-22 | 2021-05-04 | Phytoplant Research S.L | CANNABINOID PURIFICATION METHOD |
EP3061510A1 (en) | 2015-02-27 | 2016-08-31 | Bionorica Ethics GmbH | Cpc partition chromatography of cannabinoids |
BG112018A (en) * | 2015-05-22 | 2016-11-30 | "Побелч-Гле" Оод | A method for extracting a cannabinoid derivative from hemp |
-
2019
- 2019-01-29 EP EP19702843.4A patent/EP3746419A1/en active Pending
- 2019-01-29 CA CA3089490A patent/CA3089490A1/en active Pending
- 2019-01-29 WO PCT/EP2019/052069 patent/WO2019145552A1/en active Search and Examination
- 2019-01-29 MX MX2020007960A patent/MX2020007960A/en unknown
- 2019-01-29 AU AU2019211188A patent/AU2019211188A1/en not_active Abandoned
- 2019-01-29 CN CN201980015943.2A patent/CN111788171A/en active Pending
-
2020
- 2020-07-13 IL IL276010A patent/IL276010A/en unknown
- 2020-07-27 CL CL2020001964A patent/CL2020001964A1/en unknown
- 2020-08-06 CO CONC2020/0009747A patent/CO2020009747A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2019211188A1 (en) | 2020-07-30 |
CA3089490A1 (en) | 2019-08-01 |
IL276010A (en) | 2020-08-31 |
WO2019145552A1 (en) | 2019-08-01 |
CO2020009747A2 (en) | 2020-08-21 |
EP3746419A1 (en) | 2020-12-09 |
CL2020001964A1 (en) | 2020-12-18 |
CN111788171A (en) | 2020-10-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020007960A (en) | Methods of purifying cannabinoids using liquid:liquid chromatography. | |
HRP20201230T1 (en) | Use of cannabinoids in the treatment of atonic seizures in lennox-gastaut syndrome | |
HRP20201325T1 (en) | Use of cannabidiol in the treatment of tuberous sclerosis complex | |
MX2019011583A (en) | Process for purification and separation of cannabinoids from dried hemp and cannabis leaves. | |
MX2019001286A (en) | Cannabis composition. | |
MX2020006965A (en) | Oral pharmaceutical formulation comprising cannabinoids and poloxamer. | |
CO2018006452A2 (en) | Compositions of cannabis oil and methods for preparing them | |
MX2021006094A (en) | Use of cannabinoids in the treatment of epilepsy. | |
MX2021000814A (en) | Use of cannabinoids in the treatment of epilepsy. | |
BR112019006106A2 (en) | cannabinoid loaded formulation, process for preparing the cannabinoid loaded formulation, pharmaceutical and nutraceutical compositions, and method of treating an individual suffering from a disease or disorder. | |
RU2020127876A (en) | USE OF CANNABINOIDS IN THE TREATMENT OF EPILEPSY | |
GB201116789D0 (en) | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (cbdv) and cannabidiol (cbd) | |
WO2020117688A3 (en) | Process for purifying tetrahydrocannabinol using a chromatographic stationary phase | |
BR112017008301A2 (en) | cannabis extracts and methods of preparation and use | |
BR112019006642A2 (en) | highly potent multimeric e-selectin antagonists | |
MX2020001443A (en) | Phytochemical extraction system and methods to extractphytochemicals from plants including plants of the familycannabaceae sensu stricto. | |
IN2014DN09507A (en) | ||
MX2021009646A (en) | Use of cannabinoids in the treatment of epilepsy. | |
MX2020005719A (en) | Use of cannabinoids in the treatment of epilepsy. | |
NO20076252L (en) | Ophthalmic devices for continuous delivery of active compounds | |
MX2021000020A (en) | Composition and method for treating pain. | |
LT2016046A (en) | The oleo gel composition and delivery system with active compounds from c. sativa and m. arvensis for reduction of inflamation and pain in deep tissues | |
BRPI0812609A2 (en) | A method for separating at least one component from a composition comprising at least two seed oil derivatives | |
BR112021022139A2 (en) | Cannabidiol preparation, and, method for treating a patient suffering from epileptic spasms | |
Wei et al. | Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1 |