CO2020009747A2 - Methods to purify cannabinoids using liquid-liquid chromatography - Google Patents
Methods to purify cannabinoids using liquid-liquid chromatographyInfo
- Publication number
- CO2020009747A2 CO2020009747A2 CONC2020/0009747A CO2020009747A CO2020009747A2 CO 2020009747 A2 CO2020009747 A2 CO 2020009747A2 CO 2020009747 A CO2020009747 A CO 2020009747A CO 2020009747 A2 CO2020009747 A2 CO 2020009747A2
- Authority
- CO
- Colombia
- Prior art keywords
- liquid
- cannabinoids
- methods
- chromatography
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
- C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente memoria descriptiva da a conocer métodos para purificar uno o más cannabinoides a partir de un material vegetal usando sistemas de disolvente bifásico únicos y cromatografía líquido-líquido como cromatografía de partición centrífuga (CPC) o cromatografía a contracorriente (CCC). La presente memoria descriptiva también proporciona cannabinoides purificados tales como CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA y THCV, composiciones que comprenden uno o más de estos cannabinoides producidos mediante el método dado a conocer, y métodos para tratar una enfermedad o estado empleando tales cannabinoides purificados y composiciones.The present specification discloses methods for purifying one or more cannabinoids from plant material using unique biphasic solvent systems and liquid-liquid chromatography such as centrifugal partition chromatography (CPC) or counter current chromatography (CCC). The present specification also provides purified cannabinoids such as CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA, and THCV, compositions comprising one or more of these cannabinoids produced by the disclosed method, and methods for treating a disease or condition employing such purified cannabinoids and compositions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/882,516 US10207198B2 (en) | 2015-01-22 | 2018-01-29 | Methods of purifying cannabinoids using liquid:liquid chromatography |
PCT/EP2019/052069 WO2019145552A1 (en) | 2018-01-29 | 2019-01-29 | Methods of purifying cannabinoids using liquid:liquid chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020009747A2 true CO2020009747A2 (en) | 2020-08-21 |
Family
ID=65276144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0009747A CO2020009747A2 (en) | 2018-01-29 | 2020-08-06 | Methods to purify cannabinoids using liquid-liquid chromatography |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP3746419A1 (en) |
CN (1) | CN111788171A (en) |
AU (1) | AU2019211188A1 (en) |
CA (1) | CA3089490A1 (en) |
CL (1) | CL2020001964A1 (en) |
CO (1) | CO2020009747A2 (en) |
IL (1) | IL276010A (en) |
MX (1) | MX2020007960A (en) |
WO (1) | WO2019145552A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020252369A1 (en) * | 2019-06-14 | 2020-12-17 | Purisys Llc | Crystalline cannabigerol |
CN110590511B (en) * | 2019-09-11 | 2021-05-28 | 上海同田生物技术股份有限公司 | Method for simultaneously separating cannabidiol and cannabigerol |
CN112279752B (en) * | 2020-10-30 | 2022-11-11 | 云南芙雅生物科技有限公司 | Supercritical carbon dioxide extraction method of cannabinoids for industrial cannabis sativa |
CN113135885A (en) * | 2021-04-07 | 2021-07-20 | 上海同田生物技术有限公司 | Method for separating and purifying tetrahydrocannabinol by high-speed counter-current chromatography |
AU2022375771A1 (en) | 2021-10-26 | 2024-05-23 | Ecofibre USA Inc. | Methods of treating ovarian cancer with hemp extract |
US11857590B2 (en) * | 2021-10-26 | 2024-01-02 | Ecofibre Limited | Systems and methods for producing hemp extracts and compositions |
AU2022379618A1 (en) | 2021-10-26 | 2024-05-23 | Ecofibre USA Inc. | Methods of treating endometriosis and other non-cancer gynecological disorders with hemp extract |
CN115385780B (en) * | 2022-08-26 | 2024-02-27 | 晨光生物科技集团股份有限公司 | Secondary cannabidiol crystal polymorph and preparation method and application thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0166088B1 (en) | 1990-01-23 | 1999-01-15 | . | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
ES2305437T3 (en) * | 2002-02-01 | 2008-11-01 | Resolution Chemicals Limited | DELTA-9 TETRAHIDROCANNABINOL PRODUCTION. |
US20080103193A1 (en) * | 2006-10-26 | 2008-05-01 | Trevor Percival Castor | Methods for making compositions and compositions for treating pain and cachexia |
US10155708B2 (en) * | 2015-01-22 | 2018-12-18 | Phytoplant Research S.L. | Methods of purifying cannabinoids, compositions and kits thereof |
BR122019001241B1 (en) | 2015-01-22 | 2021-05-04 | Phytoplant Research S.L | CANNABINOID PURIFICATION METHOD |
EP3061510A1 (en) | 2015-02-27 | 2016-08-31 | Bionorica Ethics GmbH | Cpc partition chromatography of cannabinoids |
BG112018A (en) * | 2015-05-22 | 2016-11-30 | "Побелч-Гле" Оод | A method for extracting a cannabinoid derivative from hemp |
-
2019
- 2019-01-29 EP EP19702843.4A patent/EP3746419A1/en active Pending
- 2019-01-29 CA CA3089490A patent/CA3089490A1/en active Pending
- 2019-01-29 WO PCT/EP2019/052069 patent/WO2019145552A1/en active Search and Examination
- 2019-01-29 MX MX2020007960A patent/MX2020007960A/en unknown
- 2019-01-29 AU AU2019211188A patent/AU2019211188A1/en not_active Abandoned
- 2019-01-29 CN CN201980015943.2A patent/CN111788171A/en active Pending
-
2020
- 2020-07-13 IL IL276010A patent/IL276010A/en unknown
- 2020-07-27 CL CL2020001964A patent/CL2020001964A1/en unknown
- 2020-08-06 CO CONC2020/0009747A patent/CO2020009747A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2019211188A1 (en) | 2020-07-30 |
CA3089490A1 (en) | 2019-08-01 |
IL276010A (en) | 2020-08-31 |
WO2019145552A1 (en) | 2019-08-01 |
MX2020007960A (en) | 2020-09-24 |
EP3746419A1 (en) | 2020-12-09 |
CL2020001964A1 (en) | 2020-12-18 |
CN111788171A (en) | 2020-10-16 |
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