JPS5679689A - Novel oxazolidinone derivative and its preparation - Google Patents

Novel oxazolidinone derivative and its preparation

Info

Publication number
JPS5679689A
JPS5679689A JP15690079A JP15690079A JPS5679689A JP S5679689 A JPS5679689 A JP S5679689A JP 15690079 A JP15690079 A JP 15690079A JP 15690079 A JP15690079 A JP 15690079A JP S5679689 A JPS5679689 A JP S5679689A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
alkyl
titled compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15690079A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP15690079A priority Critical patent/JPS5679689A/en
Publication of JPS5679689A publication Critical patent/JPS5679689A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound of formula I (R is alkyl).
EXAMPLE: 5-( 4-Indoloxymethyl )-3-isopropyloxazolidin-2-one.
USE: Synthetic intermediates of medicines: for example, a product resulting from the hydrolysis of the titled compound has β-adrenergic ganglion blocking activity and is used as a remedy or propylactis for arrhythmia, atrial fibrillation and coronary diseases.
PREPARATION: The reaction between a compound of formula II and another compound of formula III (R1 is H, alkyl, aryl, aralkyl; X is halogen) is conducted in the presence of a basic substance such as potassium hydroxide, sodium methylate or pyridine in a solvent of benzene or ether at 50W200°C and the product is catalytically hydrogenated in the presence of a catalyst such as platinum or palladium or chemically reduced with a reducing agent such as sodium borohydride to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP15690079A 1979-12-05 1979-12-05 Novel oxazolidinone derivative and its preparation Pending JPS5679689A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15690079A JPS5679689A (en) 1979-12-05 1979-12-05 Novel oxazolidinone derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15690079A JPS5679689A (en) 1979-12-05 1979-12-05 Novel oxazolidinone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5679689A true JPS5679689A (en) 1981-06-30

Family

ID=15637844

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15690079A Pending JPS5679689A (en) 1979-12-05 1979-12-05 Novel oxazolidinone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5679689A (en)

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