JPS5679689A - Novel oxazolidinone derivative and its preparation - Google Patents
Novel oxazolidinone derivative and its preparationInfo
- Publication number
- JPS5679689A JPS5679689A JP15690079A JP15690079A JPS5679689A JP S5679689 A JPS5679689 A JP S5679689A JP 15690079 A JP15690079 A JP 15690079A JP 15690079 A JP15690079 A JP 15690079A JP S5679689 A JPS5679689 A JP S5679689A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparation
- alkyl
- titled compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The titled compound of formula I (R is alkyl).
EXAMPLE: 5-( 4-Indoloxymethyl )-3-isopropyloxazolidin-2-one.
USE: Synthetic intermediates of medicines: for example, a product resulting from the hydrolysis of the titled compound has β-adrenergic ganglion blocking activity and is used as a remedy or propylactis for arrhythmia, atrial fibrillation and coronary diseases.
PREPARATION: The reaction between a compound of formula II and another compound of formula III (R1 is H, alkyl, aryl, aralkyl; X is halogen) is conducted in the presence of a basic substance such as potassium hydroxide, sodium methylate or pyridine in a solvent of benzene or ether at 50W200°C and the product is catalytically hydrogenated in the presence of a catalyst such as platinum or palladium or chemically reduced with a reducing agent such as sodium borohydride to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15690079A JPS5679689A (en) | 1979-12-05 | 1979-12-05 | Novel oxazolidinone derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15690079A JPS5679689A (en) | 1979-12-05 | 1979-12-05 | Novel oxazolidinone derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5679689A true JPS5679689A (en) | 1981-06-30 |
Family
ID=15637844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15690079A Pending JPS5679689A (en) | 1979-12-05 | 1979-12-05 | Novel oxazolidinone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5679689A (en) |
-
1979
- 1979-12-05 JP JP15690079A patent/JPS5679689A/en active Pending
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