JPS5643266A - Production of piperidinopropanol derivative - Google Patents
Production of piperidinopropanol derivativeInfo
- Publication number
- JPS5643266A JPS5643266A JP11892679A JP11892679A JPS5643266A JP S5643266 A JPS5643266 A JP S5643266A JP 11892679 A JP11892679 A JP 11892679A JP 11892679 A JP11892679 A JP 11892679A JP S5643266 A JPS5643266 A JP S5643266A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formula
- hydroxypropiophenone
- benzyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: 4-Hydroxypropiophenone without protection of the hydroxyl with a group such as benzyl is used as a starting material to produce the title compound used as a drug having an activity of improving cerebrocirculation metabolism in high yield.
CONSTITUTION: 4-Hydroxypropiophenone is halogenated with a halogen to give an α-halogenopropiophenone derivative of formula formula I(X is halogen), which is made to react with 4-benzylpiperidine to form α-piperidinopropiophenone derivative of formula II or its salt. The product is hydrogenated in the presence of a catalyst of Pd/C or the like at room temperature or at the boiling point of the solvent under a pressure of 2W50kg/cm2 to give 1-(4-hydroxyphenyl)-2-(4-benzyl-piperidino)-propanol-1 or its salt. The reaction is effected preferably in an inert solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11892679A JPS5643266A (en) | 1979-09-17 | 1979-09-17 | Production of piperidinopropanol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11892679A JPS5643266A (en) | 1979-09-17 | 1979-09-17 | Production of piperidinopropanol derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5643266A true JPS5643266A (en) | 1981-04-21 |
Family
ID=14748611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11892679A Pending JPS5643266A (en) | 1979-09-17 | 1979-09-17 | Production of piperidinopropanol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5643266A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2471374A1 (en) * | 1979-12-07 | 1981-06-19 | Cosmos Enterprise | NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS |
-
1979
- 1979-09-17 JP JP11892679A patent/JPS5643266A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2471374A1 (en) * | 1979-12-07 | 1981-06-19 | Cosmos Enterprise | NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT59376A (en) | Process for producing r(+)-n-propargyl-1-aminoindane and pharmaceutical compositions comprising such compound | |
JPS5643266A (en) | Production of piperidinopropanol derivative | |
JPS56125347A (en) | Preparation of dipeptide | |
JPS5615287A (en) | Pyrazoloindazole derivative and its preparation | |
JPS5422304A (en) | Preparation of epoxdes | |
JPS54151987A (en) | Preparation of 3',5'-disubstituted-2'-deoxy-beta-uridines and 2'-deoxy-beta-urdines | |
JPS5728046A (en) | Preparation of 4-substituted indole | |
JPS5785346A (en) | Cyclohexanecarboxylic acid derivative | |
GR78203B (en) | ||
JPS52133914A (en) | Preparation of acetaldehyde | |
JPS5649324A (en) | Preparation of acetylene derivative | |
JPS5679689A (en) | Novel oxazolidinone derivative and its preparation | |
JPS51138650A (en) | Process for preparing optically active trans-cyclopentene-3,5,-diolmon oester | |
JPS5432480A (en) | Novel preparation of piperidine derivatives | |
JPS5257142A (en) | Process for preparing dihalovinyl-cyclopropanecarboxylic acid derivati ves | |
JPS56135482A (en) | Production of 5-methyl-2-frufural | |
JPS5321172A (en) | Preparation of pyridine | |
JPS57134448A (en) | Production of diaralkylamine | |
JPS5419985A (en) | Production of hydroxycarbostyril derivative | |
Hatton | PRODUCTION OF HIGHER HYDRIDES OF BORON BY GAMMA RAY RADIOLYSIS OF DECABORANE (14); CHARACTERIZATION OF THE ELEVEN ISOMERS OF ICOSABORANE (26), B (20) H (26), AND SEPARATION AND MASS SPECTRAL IDENTIFICATION OF FOURTEEN ISOMERS OF TRIACONTABORANE (38), B (30) H (38) | |
JPS539730A (en) | Preparation of optical active n-substituted diarylsulfinylimines | |
JPS5677257A (en) | Drug having beta-blocking activity | |
JPS5395909A (en) | Preparation of hydroxycitronellal | |
JPS5446784A (en) | Production of 3-hydroxy-4-pyrone analog | |
JPS57163373A (en) | Sesquiterpenoid compound, its preparation, and antihepatitis agent comprising it as active ingfedient |