JPH10179614A - Denture stabilizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To give superior fixing power and retaining and cushioning performance for a denture, by using a polyvinyl acetate resin and a lower alkyl vinylether/maleic anhydride copolymer or a derivative thereof together and mixing a polypropylene glycol therewith. SOLUTION: This denture stabilizer uses a polyvinyl acetate resin and a lower alkyl vinylether/maleic anhydride copolymer or a derivative thereof together and is mixed with a polypropylene glycol. The polyvinyl acetate resin to be used has preferable a 100-7,000 average polymerization degree and it is allowed to use one or more kinds to be combined. On the other hand, as the lower alkyl vinylether/maleic anhydride copolymer and a derivative thereof, the one containing a 1-8C lower alkyl group is used. To demonstrate the fixing power and the retaining performance of this denture stabilizer on a denture, it is preferable to use the one with a 20,000-140,000 weight average molecular weight.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has an excellent adhesive strength required for fixing an incompatible denture, a long lasting adhesive strength, a cushioning property for relieving pain during occlusion, and a releasability after use. It relates to an excellent denture stabilizer.

[0002]

2. Description of the Related Art A denture stabilizer is used to temporarily fix an incompatible denture caused by the absorption or deformation of a ridge due to aging to the palatal mucosa,
High effect has been recognized as a supplement for conversation and the like.

[0003] The denture stabilizers currently on the market are roughly classified into two types depending on the mechanism of fixing the denture to the mucous membrane.

[0004] First, a water-insoluble rubber paste-like preparation is buried in the gap between the denture base and the mucous membrane to remove air therebetween,
It is a "close contact type" in which the denture is vacuum-adsorbed to the mucous membrane. In Japan, this close contact type is the mainstream of denture stabilizers. In this case, as the main component of the adhesion type, generally, a vinyl acetate resin having an average degree of polymerization of 200 to 7,000 (JP-B-60-21123, JP-B-1-9018) has a suitable elasticity. It is used as the main ingredient.

The other is "adhesive type", which uses a water-soluble adhesive polymer as a main agent, absorbs saliva in the mouth between the denture base and the mucous membrane to exhibit adhesiveness, and sticks the denture to the mucous membrane.
Here, various dosage forms such as powder, paste, liquid, and sheet are provided. Overseas, this adhesive type is dominant. This adhesive-type base material includes, as a high-viscosity, water-soluble polymer having an adhesive property, natural substances such as karaya gum, gum arabic, and tragacanth gum, sodium alginate, sodium carboxymethylcellulose, and metal salts of polyacrylic acid. Synthetic or semi-synthetic polymers such as polyethylene oxide and polyvinylpyrrolidone are used alone or in combination.

Conventionally, the two types of denture stabilizers have been present because the two types have contradictory characteristics.

[0007] That is, since the close contact type is rubbery, in addition to the function of fixing the denture, it also serves as a cushioning material that relieves pain caused by contact and irritation of the incompatible part of the denture with the gums and mucous membrane during occlusion. It also has functions. In addition, since this type is insoluble in water, it can be used continuously for 2 to 3 days, and since the components do not elute with saliva or the like during use, it has an excellent feeling of use without discomfort and unpleasant taste. There are advantages too.

However, since this type is fixed by vacuum suction, it is difficult to obtain a strong fixing force as compared with the adhesive type. Further, some denture materials have drawbacks such that they cannot be applied because the preparation does not adhere to the denture base. Further, in this type, the preparation remains on the denture base even after use, so that it is necessary to peel it off with the fingers. However, since the conventional product has poor releasability, many studies have been made to improve this (Japanese Patent Application Laid-Open (JP-A) No. 2002-110572). Showa 61
-73648, JP-A-62-129210, JP-A-62-265209, JP-A-1-180807, JP-A-2-124808, JP-A-2-292207,
JP-A-4-149110, JP-A-5-65210,
JP-A-5-65211).

On the other hand, the adhesive type does not depend on the material of the denture,
Both exhibit strong fixing force due to adhesion. It also has the advantage of excellent usability such as application to denture base and cleaning after use. On the other hand, this type cannot expect a cushioning effect like the close contact type, and the use period is limited to one day because the preparation gradually dissolves and loses during use. In addition, there are drawbacks such as uncomfortable feeling and unpleasant taste such as sticky and sticky due to dissolution, and studies for increasing the sustainability have been made conventionally (JP-A-47-44895, JP-B-62-54502, JP-B-2-24804, JP-B-2-39550, JP-B-4-55161, JP-B4-61843, JP-A-63-115805, JP-A-63-128009,
Japanese Patent Publication No. 7-87849, Japanese Patent Laid-Open No. 1-110619,
JP-A 1-229086, JP-A 3-17104,
JP-A-4-169508, JP-A-7-112909
And Japanese Patent Application Laid-Open No. 6-504066, and Japanese Patent Application Laid-Open No. 6-504066.
197 publication).

However, these proposals only partially improve the disadvantages of both types of denture stabilizers. On the market, there is a need for a "adhesive / adhesive type" denture stabilizer which has the advantages of both types. Examination is desired.

Further, the study of mixing vinyl acetate resin, which is the main component of the adhesion type, with the water-soluble polymer, which is the main component of the adhesive type, is based on the combination of vinyl acetate resin + alginate + carboxymethylcellulose + emulsifier 1
Combination of vinyl acetate resin and specific water-soluble polymer such as hydroxyethylcellulose and hydroxymethylcellulose (JP-A-5-652).
No. 10) has been proposed.

However, the latter proposal aims at improving the peelability of the contact type, and the former has poor usability and peelability, and does not have the advantages of both types of denture stabilizers. Has been desired.

The present invention solves the above-mentioned problems, and has both excellent fixation strength of dental prosthesis, its continuity and cushioning property, good feeling in use, and good peelability from denture base. An object of the present invention is to provide a denture stabilizer having the advantages of a denture stabilizer.

[0014]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and as a result, have found that a lower alkyl vinyl ether / maleic anhydride copolymer or By using the derivative in combination, and further blending it with polypropylene glycol, the functional strength of the denture fixing force and the persistence of the fixing effect, the cushioning property is excellent, and the usability such as usability and peelability is also excellent. The present inventors have found that an adhesive / adhesive type denture stabilizer can be obtained, and have accomplished the present invention.

Accordingly, the present invention provides a denture stabilizer comprising a combination of a vinyl acetate resin and a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, and blended with polypropylene glycol. .

Hereinafter, the present invention will be described in more detail.
The vinyl acetate resin used in the present invention has an average degree of polymerization of 100.
７7,000, preferably 200-5,000, and may be used alone or in combination of two or more having different degrees of polymerization. If the average degree of polymerization of the vinyl acetate resin is less than 100, affinity with the denture base is strong, and peeling after use is difficult. If it exceeds 7,000, the preparation is too hard, and the fixation force and cushioning properties of the denture decrease. There are cases.

The amount of the vinyl acetate resin is preferably at least 20% (% by weight, the same applies hereinafter), more preferably 20%.
-80%, more preferably 20-70%. If the amount is less than 20%, the cushioning property and the peelability from the denture tend to be poor.

On the other hand, as the lower alkyl vinyl ether / maleic anhydride copolymer and its derivatives, lower alkyl groups having 1 to 8 carbon atoms, particularly 1 to 6 carbon atoms, are used. Maleic acid copolymer, ethyl vinyl ether maleic anhydride copolymer, propyl vinyl ether maleic anhydride copolymer,
Isobutyl vinyl ether maleic anhydride copolymers and the like, calcium salts, sodium salts, zinc salts, strontium salts, magnesium salts, and the like are used, and examples of the derivatives include esters with alcohols having 1 to 8 carbon atoms. Can be used alone or in combination of two or more.

The lower alkyl vinyl ether / maleic anhydride copolymer and its derivative used in the present invention are used in order to exert the fixing power of a denture and its sustainability in the range of 20,000 to 20,000.
Those having a weight average molecular weight of 140,000 are preferred, and more preferably 40,000 to 100,000 products are used. If the molecular weight of the lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof is less than 20,000, the viscosity is low, the fixation of the denture is insufficient, and the durability of the fixation effect is problematic. It may be difficult to dissolve in water and may not exhibit adhesiveness.

The content of the lower alkyl vinyl ether / maleic anhydride copolymer and its derivative is preferably at least 31%, preferably 31-80%, more preferably 35%.
~ 70%. When the amount is less than 31%, the adhesiveness is insufficiently developed, and the durability of the fixing force tends to be poor.

Polypropylene glycol is blended in the denture stabilizer of the present invention. The polypropylene glycol having a weight average molecular weight of 500 to 8,000 in order to exhibit releasability from the denture after use is used. It is preferable to use those of 1,000 to 6,000. If the molecular weight is less than 500, the peelability tends to decrease, and if it exceeds 8,000, the denture stabilizer may be solidified.

The compounding amount of the polypropylene glycol is 1 to
It is good to be 10%, preferably 2 to 7%.
If the blending amount of the polypropylene glycol is less than 1%, the desired effect cannot be exerted. If the blending amount exceeds 10%, the fixing force may be reduced or defects such as liquid separation may occur.

The denture stabilizer of the present invention includes, in addition to a vinyl acetate resin and a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof, karaya gum, gum arabic, tragacanth gum, tamarind gum, locust bean gum, guar gum, xanthan gum. , Carrageenan, pectin, gelatin, alginic acid salts or propylene glycol esters, sodium carboxymethylcellulose, metal salts of polyacrylic acid, polyethylene oxide, polyvinyl alcohol, one or more other water-soluble polymers such as polyvinylpyrrolidone. You may use together.

The denture stabilizer of the present invention may contain, if necessary, other components such as non-toxic oils and fats, waxes, emulsifiers,
A water-insoluble powder, a wetting agent, water, a pH adjuster, a preservative, a dye or pigment, a fragrance, and the like can be added, and processed into a paste or sheet form. Non-toxic oils and waxes include hardened vegetable oils, beeswax, wood wax, candelilla wax, microcrystalline wax, paraffin wax, carnauba wax and the like. Examples of the emulsifier include mono-triglyceride of stearic acid, mono-triglyceride of oleic acid, saccharified fatty acid esters, acetylated glyceryl monostearate such as acetyl glyceryl monostearate, and sorbitan monostearate. Water-insoluble powders include calcium carbonate, calcium hydrogen phosphate, silica, zeolite, plastic powders such as polyethylene and polypropylene,
Cellulose powder or the like is used. Ethanol, propanol, glycerin, sugar alcohol,
Ethylene glycol, polyethylene glycol, triacetyl glycerin, diacetyl glycerin, ethylene glycol diacetate and the like are used.

The denture stabilizer of the present invention can be produced and used in the same manner as a known denture stabilizer using the above-mentioned components.

[0026]

EFFECTS OF THE INVENTION The denture stabilizer of the present invention is excellent in the fixing power of a denture and its persistence, has good cushioning properties, has a good feeling in use, and has good releasability.

[0027]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to experimental examples and examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Experimental Example] A denture stabilizer having the following composition was prepared and subjected to a use test by the following method. Table 1 shows the results.

[0029] Denture stabilizer composition of the present invention (adhesive / adhesive type, paste form) Vinyl acetate resin (average degree of polymerization 1,500) 40.0% Calcium salt of methoxyethylene maleic anhydride copolymer 35.0 (weight average molecular weight) 70,000) Polypropylene glycol (average molecular weight: 3,000) 3.0 60% ethanol Balance meter: 100.0% Comparative denture stabilizer composition 1 (coherent type, paste) Vinyl acetate resin (average degree of polymerization: 1,500) 0% light calcium carbonate 3.0 beeswax 3.0 polypropylene glycol (average molecular weight 3,000) 3.0 60% ethanol balance meter 100.0% comparative denture stabilizer composition 2 (adhesive type, paste) sodium carboxymethylcellulose 32 0.0% (weight average molecular weight 100,000) polyethylene oxide ( (Weight average molecular weight 1,000,000) 13.0 Vaseline 40.0 pH adjuster 0.2 Fragrance 0.03 Preservatives Trace pigment Trace liquid paraffin Balance meter 100.0%

Use test method Forty-eight maxillary complete denture users were divided into six groups, and each had three types of denture stabilizers used at least three times each for one week in a predetermined order. Investigate the items shown in 1 and evaluate according to the following criteria, calculate the average value,
Statistical analysis was performed. <Evaluation criteria> 5 Good 4 Somewhat good 3 Neither 2 Somewhat bad 1 Bad

[0031]

[Table 1]

From the results shown in Table 1, the denture stabilizer of the present invention using the vinyl acetate resin in combination with the lower alkyl vinyl ether / maleic anhydride copolymer or its derivative was compared with the conventional denture stabilizers of the adhesion type and the adhesive type. Function
It was confirmed that both the usability and the feeling of use were excellent, and in particular, it was excellent in fixing power and sustainability.

Example 1 Paste Vinyl acetate resin (average degree of polymerization 800) 50.0% Calcium salt of ethoxyethylene maleic anhydride copolymer 35.0 (weight average molecular weight 100,000) Polypropylene glycol (weight average molecular weight 2) 5,000) 5.0 60% ethanol balance meter 100.0%

Example 2 Paste Vinyl acetate resin (average degree of polymerization 500) 15.0% Vinyl acetate resin (average degree of polymerization 5,000) 10.0 Calcium salt of methoxyethylene maleic anhydride copolymer 35.0 (Weight average molecular weight 70,000) Polypropylene glycol (Weight average molecular weight 3,000) 3.0 Sodium polyacrylate 5.0 Monoglyceride stearate 1.0 Glycerin 5.0 60% Ethanol Balance meter 100.0%

Example 3 Pasty Vinyl Acetate Resin (Average Degree of Polymerization 200) 25.0% Methoxyethylene Maleic Anhydride Copolymer Calcium Salt 40.0 (Weight Average Molecular Weight 70,000) Polypropylene Glycol (Weight Average Molecular Weight 3 4.0) Beeswax 3.0 Calcium carbonate 3.0 Monoglyceride oleate 1.0 Ethanol Balance meter 100.0%

Example 4 Paste-like vinyl acetate resin (average degree of polymerization 500) 30.0% Calcium salt of methoxyethylene maleic anhydride copolymer 20.0 (weight average molecular weight 70,000) Polypropylene glycol (weight average molecular weight 3) 5,000) 5.0 Triacetylglycerin 5.0 Polyethylene glycol 10.0 70% Ethanol Balance meter 100.0%

Example 5 Paste Vinyl acetate resin (average degree of polymerization 1,500) 30.0% Calcium salt of methoxyethylene maleic anhydride copolymer 31.0 (weight average molecular weight 70,000) Xanthan gum 15.0 carboxy Sodium methylcellulose 20.0 Polypropylene glycol (weight average molecular weight 5,000) 2.0 Ethanol Balance meter 100.0%

Example 6 Pasty Vinyl Acetate Resin (Average Degree of Polymerization 1,500) 25.0% Methoxyethylene Maleic Anhydride Copolymer Calcium Salt 35.0 (Weight Average Molecular Weight 70,000) Karaya Gum 5.0 Polypropylene Glycol (weight average molecular weight 3,000) 3.0 80% ethanol Balance meter 100.0%

Claims (1)

[Claims] 1. A denture stabilizer comprising a combination of a vinyl acetate resin and a lower alkyl vinyl ether / maleic anhydride copolymer or a derivative thereof and blended with polypropylene glycol.