JP3479813B2 - Denture stabilizer - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates mainly to a vinyl acetate resin having excellent extrudability from a tube even in winter and excellent storage stability during low-temperature storage. The present invention relates to a close contact type denture stabilizer. 2. Description of the Related Art A denture stabilizer is used temporarily to stabilize a denture of a dentured user of a dentured user when the denture rattles due to aging or the like. Things. This denture stabilizer is generally classified into a contact type and an adhesive type depending on the method of fixing the denture,
Dosage forms can be classified into gum, paste, powder, sheet and the like. In this case, the former close contact type denture stabilizer uses a vinyl acetate resin as a main component in terms of adhesiveness to a denture base, viscoelasticity at intraoral temperature, safety and the like.
The preparation closes and fixes the denture like a sucker by filling the gap with the oral mucosa and expelling the air inside. In the latter adhesive type, the water-soluble polymer compound is swollen by saliva in the oral cavity, and the adhesion strength of the denture is maintained and stabilized. Among such denture stabilizers, a close contact type denture stabilizer is less adhesive due to dissolution of the preparation, and can be washed off by removing the denture during use, and can be used continuously for 2 to 3 days. This type is dominant in Japan. However, the denture stabilizer of the contact type has a low elasticity at a temperature higher than the above temperature because the vinyl acetate resin as a main component is an amorphous polymer compound having a glass transition point at 30 to 35 ° C. In the following, as a result of having the property of being highly elastic, it is easy to flow when worn in the oral cavity (temperature conditions around 37 ° C.), but in winter (temperature conditions of 20 ° C. or less), the formulation can be extremely removed from the tube. In addition to being difficult to extrude, when stored at a low temperature, the vinyl acetate resin shrinks and the liquid component is extruded out of the system, so that liquid separation occurs and the denture does not adhere to the denture base. Therefore, it has been a problem to improve the usability of the close contact type denture stabilizer by improving the above problem. Japanese Patent Application Laid-Open No. Sho 60-253440 discloses that a low-, medium-, and high-polymerization degree vinyl acetate resin is combined and mixed to improve low-temperature extrusion properties and high-temperature storage stability. Although it has been proposed to obtain such a technique, development of a more effective technique is desired. SUMMARY OF THE INVENTION The present invention has been made to meet the above-mentioned demands, and it is an object of the present invention to provide an adhesive denture stabilizer which is excellent in extrudability from a tube even in winter and has good storage stability during low-temperature storage. With the goal. The present inventors have conducted intensive studies in order to achieve the above-mentioned object, and as a result, have found that vinyl acetate resin accounts for 30 to 80% of the whole preparation (% by weight, hereinafter the same).
And methyl acetyl ricinoleate or butyl acetyl ricinoleate (hereinafter, both are collectively referred to as oxyacid ester) in an amount of 1 to 30% of the whole preparation, so that the adhesive type mainly composed of vinyl acetate resin is used. It has been found that the extrudability and storage stability of a denture stabilizer at low temperatures can be satisfactorily improved. That is, the present inventor has surprisingly found that, when the oxyacid ester is used in combination with the vinyl acetate resin in the above-mentioned amount, the glass transition point of the vinyl acetate resin is unexpectedly shifted to a low temperature of 10 ° C. or less. As described in Japanese Unexamined Patent Publication No. 60-253440, it is possible to easily extrude from a tube at a low temperature in winter without combining vinyl acetate resins having various degrees of polymerization, and the vinyl acetate resin shrinks during storage at a low temperature and the liquid The present inventors have found that a denture stabilizer that can be sufficiently adhered to a denture base without separation and that has excellent usability can be obtained, and the present invention has been accomplished. Therefore, the present invention provides a dental prosthesis characterized in that a vinyl acetate resin is used in an amount of 30 to 80% of the whole, and methyl acetyl ricinoleate or butyl acetyl ricinoleate is used in an amount of 1 to 30% of the whole. Provide the agent. Hereinafter, the present invention will be described in more detail. The denture stabilizer of the present invention comprises a combination of a vinyl acetate resin and an oxyester. As the vinyl acetate resin, those having an average degree of polymerization of 500 to 3000 are preferable, but those having an average degree of polymerization of 50 to 1000 and those having an average degree of polymerization of 2000 to 6000 are preferred.
The average polymerization degree may be in the range of 500 to 3000 as a whole by mixing and using two or more kinds of vinyl acetate resins having different average polymerization degrees. [0012] The compounding amount of the vinyl acetate resin is 3
0 to 80%, preferably 40 to 75%, more preferably 50 to 70%. As the oxyacid ester, methyl acetyl ricinoleate and butyl acetyl ricinoleate are used. The amount of the oxyacid ester is 1 to 30%, preferably 3 to 20%, more preferably 4 to 30% of the whole preparation.
If the amount is less than 1%, the desired effect cannot be sufficiently exerted. If the amount exceeds 30%, the preparation becomes hard, and the vinyl acetate resin is reduced in total balance. Defects such as lowering are likely to occur. [0015] The denture stabilizer of the present invention may contain other components other than the above components, if necessary, such as propylene glycol.
Non-toxic oils and fats, emulsifiers, water-insoluble powders, enzymes, bactericides, water, ethanol, pH adjusters, pigments, fragrances, and the like can be added. Specifically, non-toxic oils and fats
Waxes such as beeswax, wood wax, candelilla wax, microcrystalline wax, paraffin wax, carnauba wax and the like, emulsifiers such as monoglyceride stearate, monoglyceride oleate, acetylated glyceryl fatty acid ester, sorbitan monostearate, sucrose fatty acid ester, etc. As insoluble powder,
Calcium carbonate, titanium oxide, calcium hydrogen phosphate,
As enzymes such as calcium sulfate, zeolite, silicon dioxide, plastic powder, and cellulose powder, dextranase, mutanase, β-1,3-glucanase,
Examples of fungicides such as amylase include triclosan, cetylpyridinium chloride, benzethonium chloride, and chlorhexidine. In addition, the addition amount of these components,
The amount can be a usual amount within a range not to impair the effects of the present invention. EFFECT OF THE INVENTION The denture stabilizer of the present invention can be easily extruded from a tube even at a low temperature in winter and has excellent storage stability without liquid separation even when stored at a low temperature. And can adhere well to the denture base, and is excellent in usability. EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, all% in each example are weight%. [Example 1, Comparative Examples 1 to 5] Denture stabilizers having the compositions shown in Table 1 were prepared by a conventional method, and the extrudability from a tube and the state of liquid separation were evaluated by the following methods. The results are also shown in Table 1. Extrudability from tube: After filling the denture stabilizer into the tube, the tube was allowed to stand at low temperature (-5 ° C) for one week, then squeezed out of the tube, and the ease of extrusion was evaluated according to the following criteria. ：: good △: slightly bad ×: bad liquid separation: After filling the denture stabilizer into a tube, low temperature (-5 ° C, -5
(5 ° C cycle) for 3 months, then squeezed out of the tube, and the state of liquid separation was evaluated according to the following criteria. ：: When the formulation was extruded from the tube, the surface of the paste was not wet. Δ: When the formulation was extruded from the tube, the surface of the paste was wet. ×: When the tube is opened, liquid comes out from the mouth. From the results shown in Table 1, the denture stabilizer of the present invention was
It was confirmed that even at a low temperature, the extrudability from the tube was excellent, and there was no liquid separation after storage at a low temperature, and the storage stability was excellent. [Table 1] [Embodiment 2] [Embodiment 3] [Embodiment 4]

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-60-11406 (JP, A) JP-A-60-23465 (JP, A) JP-A-4-149110 (JP, A) JP-A-60-160 253440 (JP, A) JP-A-53-76591 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 6/00 A61C 13/23

Claims (1)

(57) [Claims 1] A composition containing 30 to 80% by weight of vinyl acetate resin and 1 to 30% by weight of methyl acetyl ricinoleate or butyl acetyl ricinoleate. A denture stabilizer, characterized in that: