JP4477568B2 - Component concentration measuring apparatus and component concentration measuring apparatus control method - Google Patents

Description

  The present invention relates to a non-invasive component concentration measurement apparatus and component concentration measurement apparatus control method for a human or animal subject.

  With the aging of society, dealing with adult diseases is becoming a major issue. In blood glucose level and other tests, blood collection is necessary, which places a heavy burden on the patient. Therefore, a non-invasive component concentration measurement apparatus that does not collect blood has attracted attention. As a non-invasive component concentration measuring device that has been developed so far, the skin is irradiated with electromagnetic waves and absorbed by blood molecules to be measured, for example, glucose molecules in the case of blood glucose levels, and heated locally. A photoacoustic method that observes a sound wave generated from a living body due to thermal expansion has attracted attention.

  However, the interaction between glucose and electromagnetic waves is small, and there is a limit to the intensity of electromagnetic waves that can be safely irradiated to a living body, so that a sufficient effect has not been achieved in measuring blood glucose levels in the living body.

  6 and 7 are diagrams showing a configuration example of a conventional blood component concentration measuring apparatus using a photoacoustic method as a conventional example. FIG. 6 shows a first conventional example in which a light pulse is used as an electromagnetic wave (for example, see Non-Patent Document 1). In this example, blood glucose, that is, glucose is the measurement target as the blood component. In FIG. 6, a drive circuit 604 supplies a pulsed excitation current to a pulse light source 616, the pulse light source 616 generates a light pulse having a sub-microsecond duration, and the generated light pulse is applied to a subject 610. The The light pulse generates a sound wave called a pulsed photoacoustic signal inside the subject 610, and the generated sound wave is detected by the ultrasonic detector 613 and further converted into an electric signal proportional to the sound pressure.

  The waveform of the converted electric signal is observed by the waveform observer 620. This waveform observer 620 is triggered by a signal synchronized with the excitation current, the converted electrical signal is displayed at a fixed position on the tube surface of the waveform observer 620, and the converted electrical signal is measured by integrating and averaging. can do. The amplitude of the electrical signal thus obtained is analyzed, and the blood glucose level inside the subject 610, that is, the amount of glucose is measured. In the case of the example shown in FIG. 6, an optical pulse having a sub-microsecond pulse width is repeatedly generated at a maximum of 1 kHz, and 1024 optical pulses are averaged to measure the electrical signal. However, sufficient accuracy is obtained. It is not done.

  Therefore, a second conventional example using a light source that is continuously intensity-modulated has been disclosed for the purpose of improving accuracy. FIG. 7 shows a configuration of a device of the second conventional example (see, for example, Patent Document 1). In this example as well, blood sugar is the main measurement target, and high accuracy is attempted using a plurality of light sources having different wavelengths. In order to avoid complicated explanation, the operation when the number of light sources is 2 will be described with reference to FIG. In FIG. 7, light sources having different wavelengths, that is, a first light source 601 and a second light source 605 are driven by a drive circuit 604 and a drive circuit 608, respectively, and output continuous light.

  Light output from the first light source 601 and the second light source 605 is intermittently driven by a chopper plate 617 that is driven by a motor 618 and rotates at a constant rotational speed. Here, the chopper plate 617 is formed of an opaque material, and a relatively small number of openings are formed on the circumference around which the light of the first light source 601 and the second light source 605 passes with the axis of the motor 618 as the center. Is formed.

With the above-described configuration, the light output from each of the first light source 601 and the second light source 605 is intensity-modulated with the disjoint modulation frequency f ₁ and modulation frequency f ₂ and then combined by the combining unit 609. The object 610 is irradiated as one light beam.

The inside of the subject 610 photoacoustic signal having the frequency f ₁ is generated by the light of the first light source 601, the photoacoustic signal having the frequency f ₂ is generated by the light of the second light source 605, these photoacoustic signal Is detected by the acoustic sensor 619 and converted into an electric signal proportional to the sound pressure, and its frequency spectrum is observed by the frequency analyzer 621. In this example, the wavelengths of the plurality of light sources are all set to the absorption wavelength of glucose, and the intensity of the photoacoustic signal corresponding to each wavelength is measured as an electrical signal corresponding to the amount of glucose contained in the blood. The

Here, the relationship between the intensity of the measured value of the photoacoustic signal and the value obtained by measuring the glucose content with blood collected separately is stored in advance, and the amount of glucose is measured from the measured value of the photoacoustic signal. ing.
JP-A-10-189 University of Oulu (University of Oulu, Finland) thesis “Pulse photoacoustic technique and glucodesis in human blood and tissue” (IBS 951-42-6690-0, ul./200.

  The conventional example described above has the following problems. That is, the pulsation of a subject such as a human being or an animal is a change in blood volume (volume). Therefore, the pulsation of the subject changes the amount of light absorbed by the blood component of the subject, resulting in a change in the amount of photoacoustic signal generated.

  Therefore, the conventional method for measuring the component concentration of the subject or the object to be measured has a problem that the measurement error due to the pulsation of the subject at the time of measurement becomes very large.

  In order to solve the above problems, the present invention emits light of two different wavelengths set from the absorbance characteristics of the component to be measured at a predetermined temperature, and adjusts the temperature of the subject or the object to be measured to the predetermined temperature. Thus, there are provided a component concentration measuring apparatus and a component concentration measuring apparatus control method for accurately measuring a component concentration by detecting a sound wave generated from the subject or an object to be measured and removing an error due to pulsation of the subject. Here, the subject is a human or animal to be measured, and the same applies to the following description.

  First, the case where the component concentration of a subject is measured will be described as an example of the basic principle of the component concentration measuring device and the component concentration measuring device control method of the present invention.

  In the present invention, the wavelength of the first light among the two different wavelengths of light is set to a wavelength that is significantly different from the absorbance due to water, for example, where the absorbance due to the measurement target component of the subject occupies most of the subject. The wavelength of the second light is set to a wavelength indicating the same absorbance as that of water at the wavelength of the first light. The above-described wavelength setting method will be described with reference to FIG. 1, taking as an example the case of measuring the concentration of glucose in blood.

FIG. 1 shows the absorbance characteristics of water and an aqueous glucose solution at room temperature. In FIG. 1, the vertical axis indicates the absorbance, and the horizontal axis indicates the wavelength of light. In FIG. 1, the solid line indicates the absorbance characteristic of water, and the broken line indicates the absorbance characteristic of the glucose aqueous solution. The wavelength λ ₁ shown in FIG. 1 is a wavelength at which the absorbance due to glucose is significantly different from the absorbance due to water, and the wavelength λ ₂ is a wavelength at which water has the same absorbance as that at λ ₁ . Thus, for example, the wavelength of the first light can be set to λ ₁ and the wavelength of the second light can be set to λ ₂ .

In the following description, as an example, the wavelength of the first light is set to a wavelength λ ₁ where the absorbance of the component to be measured is significantly different from the absorbance of water, and the wavelength of the second light is the first light. The case where the wavelength λ ₂ is set to be equal to that at the wavelength λ ₁ will be described.

  Each of the two different wavelengths of light set as described above is intensity-modulated with a signal of the opposite phase at the same frequency and emitted as pulsed light, and the emitted two different wavelengths of light are absorbed by the component of the subject. Then, the generated sound wave is detected, and the concentration of the component to be measured of the subject is measured from the magnitude of the detected sound wave. When light of two different wavelengths whose intensity is modulated as described above is emitted, the first light wave generated from the subject by the absorption of the first light by both the component to be measured and water, and the second light The second sound wave generated from the subject by absorbing water occupying most of the subject has the same frequency and an opposite phase. Therefore, the first sound wave and the second sound wave are superimposed in the subject, and only the magnitude of the sound wave generated from the subject due to absorption of the component to be measured in the first sound wave is obtained as the difference between the sound waves. Remains. Therefore, only the sound wave generated from the subject by the first light being absorbed by the component to be measured can be measured by the remaining sound wave. In the above measurement, the measurement target component absorbs rather than the difference between the sound wave generated by the absorption of both the measurement target component and water and the sound wave generated by the water absorption. Thus, the sound wave generated from the subject can be accurately measured.

Furthermore, a method for measuring with high accuracy, excluding the cause of errors in the sound wave measurement system such as the contact state between the subject and the sound wave detection element, will be described below. For each of the light of wavelength λ _{1 and} the light of wavelength λ ₂ , the absorption coefficient of water occupying most of the subject is α ₁ ^(w) and α ₂ ^(w) , and the molar absorption of the component to be measured of the subject If the coefficients are α ₁ ^(g) and α ₂ ^(g) , the simultaneous equations including the magnitudes s ₁ and s ₂ of sound waves generated from the subject by the light of wavelength λ _{1 and} the light of wavelength λ ₂ are It is expressed by Equation (1).

By solving the above equation (1), the component concentration M of the subject to be measured can be obtained. Here, C is a coefficient that is difficult to control or predict, that is, the coupling state between the subject and the sound wave detection element, the sensitivity of the sound wave detection element, and the distance between the position where the sound wave is generated by light in the subject and the sound wave detection element. , specific heat and thermal expansion coefficient of the object, the speed of the internal wave of the subject, the wavelength lambda ₁ of light and the wavelength lambda ₂ of the light modulation frequencies, the molar absorption coefficient of the component of the absorption coefficient and the subject of water, etc. It depends on the unknown constant. Further, when C is eliminated by Expression (1), the following Expression (2) is obtained.

Here, the absorption coefficients α ₁ ^(w) and α ₂ ^{(w) of} water occupying most of the subject for each of the light of wavelength λ _{1 and} the light of wavelength λ ₂ are selected to be equal. , Α ₁ ^(w) = α ₂ ^(w) is satisfied, and the fact that s ₁ ≈s ₂ is used, the component concentration M is expressed by Equation (3).

Substituting α ₁ ^(w) , α ₁ ^(g), and α ₂ ^(g) as known coefficients into the above equation (3), and further by the light of wavelength λ _{1 and} the light of wavelength λ ₂ , respectively. The component concentration M of the subject can be calculated by measuring and substituting the magnitudes s ₁ and s ₂ of the sound waves generated from the subject. In the above mathematical formula (3), rather than measuring the _two sound wave sizes s ₁ and s ₂ individually, the difference s ₁ -s ₂ is measured and the sound wave size s ₂ measured separately is measured. The component concentration of the subject can be measured with high accuracy.

Therefore, in the component concentration measuring apparatus and the component concentration measuring apparatus control method of the present invention, first, the light of wavelength λ _{1 and} the light of wavelength λ ₂ are intensity-modulated by the modulation signals having opposite phases to each other to form one light beam. By combining and emitting, a difference (s ₁ −s ₂ ) between sound waves generated by superimposing the sound wave magnitude s ₁ and the sound wave magnitude s ₂ generated from the subject is measured. Next, light of wavelength λ ₂ is emitted, and the magnitude s _{2 of the} sound wave generated from the subject is measured. From (s ₁ -s ₂ ) and s ₂ measured as described above, (s ₁ -s ₂ ) ÷ s ₂ is calculated by Equation (3) to accurately determine the concentration of the measurement target component of the subject. Can be measured.

  The influence of the pulsation of the subject in the component concentration measuring apparatus and the component concentration measuring apparatus control method of the present invention is as follows.

In the present invention, the value of (s ₁ -s ₂ ) of the molecule in the mathematical formula (3) is measured as the magnitude of the sound wave generated in the subject by simultaneously irradiating light of two different wavelengths and simultaneously irradiating light. be able to. On the other hand, the value of s _{2 in} the denominator can be measured as the magnitude of a sound wave generated in the subject by separately irradiating light of a predetermined wavelength among light of two different wavelengths.

However, since the value of s ₁ -s ₂ of the numerator and the value of s ₂ of the denominator cannot be measured at the same time as described above, they are measured at different times. In this case, when the integration time of the phase detection amplification unit is set to about 100 msec to 1 sec, the value is remarkably different because it is affected by the blood vessel structural deformation due to the change in blood volume due to pulsation.

  FIG. 2 shows a graph of fluctuation due to pulsation of the sound wave size. FIG. 2 shows a case where the pulse is about 60 beats / second.

  In FIG. 2, the magnitudes 30 and 31 of the sound waves generated from the subject are the magnitude 42 of the sound waves generated from the tissue of the subject, the magnitude 41 of the sound waves generated from the venous blood, and the magnitude of the sound waves generated from the arterial blood. Measured as 40 additions. As shown in FIG. 2, the magnitude 30 of the sound wave generated by the first light and the magnitude 31 of the sound wave generated by the second light both increase and decrease in synchronization with the pulse wave 20. This is because the arterial blood vessel repeatedly expands and contracts in synchronization with the pulsation. The magnitude 32 of the sound wave generated by the mixed light of the first light and the second light is the magnitude 30 of the sound wave generated by the first light and the magnitude 31 of the sound wave generated by the second light. In the same manner as the magnitude 30 of the sound wave generated by the first light and the magnitude 31 of the sound wave generated by the second light, it is increased or decreased in synchronization with the pulse wave 20. Here, as described above, when the integration time in the phase detection amplification unit is set to about 100 msec to 1 sec, if the pulse of the human body is about 60 beats / second, the integration value varies greatly depending on the time of integration. . As a result, an error occurs in the calculated component concentration.

  In order to correct an error due to increase / decrease of the calculated concentration caused by the pulse, it is considered that the influence of the pulse wave is reduced by taking a long-time average of the magnitude of the sound wave. On the other hand, averaging the sound waves over a long period of time results in longer measurement time and mental pressure due to restraint. Therefore, in practice, it is required to shorten the measurement time.

  Therefore, in the present invention, in order to measure the magnitudes 31 and 32 of the two sound waves, the sound wave is detected and the pulse wave 20 is detected. It was decided that the time would be a predetermined value.

  Specifically, the component concentration measurement apparatus control method according to the present invention includes a pulse wave detection unit that detects a pulse wave of the subject within a predetermined time from a time when the pulse wave of the subject becomes a predetermined value. The mixed light emitting means for detecting the pulse wave within the predetermined time and electrically emitting intensity of the two different wavelengths with the signals having the same frequency and the opposite phase, and emitting the two wavelengths within the predetermined time. And a sound wave detecting means for detecting a sound wave generated in the subject detects a sound wave within the certain time, and the constant pulse wave sound wave detecting procedure from the time point of the first pulse wave sound wave detecting procedure. The pulse wave detecting means detects the pulse wave within the predetermined time within the predetermined time from another time point where the pulse wave of the subject becomes a predetermined value except for the time, and the light of the two different wavelengths First light emitting means for electrically modulating the intensity of one predetermined wavelength and emitting the same It said predetermined time light of one wavelength emitted into, and the acoustic wave detection means and having a second pulse wave detecting step of detecting an acoustic wave within the predetermined time.

In the present invention, the mixed light emitting means converts the light of two different wavelengths, that is, the wavelength of the first light and the wavelength of the second light into the absorbance characteristics of the component to be measured and the water according to the measurement principle described above. The wavelength λ ₁ and the wavelength λ ₂ selected from the above are set. In the first pulse wave sound wave detection procedure, the mixed light emitting means emits the first light and the second light by electrically modulating the intensity of each of the first light and the second light with signals having the same frequency and opposite phases. When the subject is irradiated with the first light and the second light emitted in this way, a sound wave is generated from the subject, and the sound wave detecting means detects the sound wave generated from the subject. Here, the sound wave measured by the sound wave detecting means is a difference sound wave between the first sound wave generated by the first light and the second sound wave generated by the second light.

  Further, in the second pulse wave sound wave detection procedure, the first single light emitting means modulates the intensity of the light having the same wavelength as that of the second light in the same manner as the second light, and is similar to the second light. It emits with the intensity of. When the subject is irradiated with the second light emitted in this manner, a sound wave is generated from the subject, and the sound wave detecting means detects the sound wave generated from the subject.

  Here, when the mixed light emitting means emits the first light and the second light in the first pulse wave sound wave detecting procedure, the first single light emitting means in the second pulse wave sound wave detecting procedure is the second light. The pulse wave detecting means detects the pulse wave of the subject. The time for the mixed light emitting means to emit the first light and the second light, the time for the first single light emitting means to emit the second light, and the time for the pulse wave detecting means to detect the pulse wave are as follows: Both are within a certain time from the time when the pulse wave of the subject becomes a predetermined value, and are set to a certain time triggered by the predetermined value of the pulse wave of the subject. In addition, either the first pulse wave sound wave detection procedure or the second pulse wave sound wave detection procedure may be performed first.

  Thus, in the present invention, the first and second pulse wave sound wave detection procedures are used to detect a pulse wave by using a predetermined value of the pulse wave as a trigger, and the first light and / or the second light is emitted. By detecting the sound wave, it is possible to detect the pulse wave and the sound wave when the blood volume due to the pulsation is relatively the same. Therefore, normalization of the sound wave intensity described later can be performed from the detected pulse wave and sound wave, and the influence of the change in blood flow due to pulsation on the sound wave intensity can be reduced and the component concentration can be accurately measured.

  In the component concentration measuring apparatus control method of the present invention, the pulse wave integrating means for integrating the pulse waves detected by the pulse wave detecting means to obtain the pulse wave integrated value within the predetermined time in the first pulse wave sound wave detecting procedure. The first pulse wave is obtained by sequentially integrating the pulse waves detected to obtain a pulse wave integrated value and integrating the magnitude of the sound wave detected by the sound wave detecting means to obtain the sound wave intensity. A first pulse wave sound wave intensity integrating procedure for sequentially integrating the sound waves detected within the predetermined time in the sound wave detecting procedure to obtain mixed sound wave intensity; and the pulse wave integrating means in the second pulse wave sound wave detecting procedure The pulse waves detected within a certain time are sequentially accumulated to obtain other pulse wave accumulated values, and the sound wave intensity integrating means detects the sound waves detected within the certain time in the second pulse wave sound wave detection procedure. It accumulates sequentially It is desirable to further include a second pulse wave intensity integrated procedure for acquiring as a wave intensity, a.

  The above-described first and second pulse wave sound wave intensity integration procedures are one specific procedure up to the standardization of sound wave intensity which will be described later. Here, in order to integrate the pulse wave and the sound wave, for example, the pulse wave signal and the sound wave signal are integrated by the integrating circuit, and the signal is averaged by the dividing circuit. The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also

  As described above, in the present invention, by obtaining the pulse wave integrated value and the sound wave intensity by the first and second pulse wave sound wave intensity integrating procedures, specific information necessary for normalization of the sound wave intensity is obtained and the sound wave intensity is obtained. Standardization is possible.

  In the component concentration measuring apparatus control method of the present invention, the component concentration calculating means for calculating the component concentration to be measured is a pulse acquired in the first pulse wave sound wave intensity integrating procedure and the second pulse wave sound wave intensity integrating procedure. It is desirable to further have a component concentration calculation procedure for calculating the component concentration from the wave integrated value, other pulse wave integrated value, mixed sound wave intensity, and single sound wave intensity.

  In the present invention, the component concentration can be calculated from the normalized sound wave intensity described later by the component concentration calculation procedure.

  In the component concentration measurement apparatus control method of the present invention, in the component concentration calculation procedure, the component concentration calculation means calculates the mixed sound wave intensity standard value obtained by dividing the mixed sound wave intensity by the pulse wave integrated value, and the single sound wave intensity. It is desirable to calculate the component concentration from the ratio of the single sound wave intensity standard value divided by the other pulse wave integrated value.

  In the present invention, the mixed sound wave intensity is normalized by dividing the mixed sound wave intensity by the pulse wave integrated value. Further, the single sound wave intensity is normalized by dividing the single sound wave intensity by the pulse wave integrated value. Here, the pulse wave integrated value that divides the mixed sound wave intensity is the integrated value of the sound wave and pulse wave detected at the same time as the sound wave generated by the mixed light, and the pulse wave integrated value that divides the single sound wave intensity is The integrated value of the pulse wave detected at the same time as the sound wave generated by the single light. In the present invention, in order to detect a pulse wave and a sound wave when the blood volume due to pulsation is relatively the same, by dividing the sound wave intensity by the pulse wave integrated value, a standard value is obtained and the sound wave intensity due to the pulsation is obtained. The influence of can be reduced. Therefore, in the present invention, since the component concentration is calculated by normalizing the sound wave intensity, a highly accurate calculation result can be obtained.

  Here, the predetermined value serving as the trigger for the pulse wave may be the time point of any value of the pulse wave, but is preferably the extreme value of the pulse wave (either the maximum value or the minimum value). Accumulation can be performed within an integration time within one beat without straddling the beat, so that the component concentration can be calculated accurately even with several beats (two or more beats), and the measurement interval can be shortened. Further, since the time is short, the fluctuation of the pulse interval can be reduced, and the calculation accuracy of the component concentration can be improved.

  In the component concentration measuring apparatus control method of the present invention, the predetermined time is set to be within one cycle of the pulse wave detected by the pulse wave detecting means, and the pulse wave detecting means detects two consecutive beats of the pulse wave of the subject. Minute is detected for each beat in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure, and the mixed light emitting means corresponds to the two beats in the first pulse wave sound wave detection procedure. Two different wavelengths of light are emitted after being intensity-modulated electrically with the same frequency and opposite phase signals, and the first single light emitting means corresponds to the two beats in the second pulse wave sound wave detection procedure. The light of a predetermined wavelength is electrically modulated and emitted, and the sound wave detecting means corresponds to the two beats in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure. It is desirable to detect each sound wave.

  In the present invention, since the detection time difference between the pulse wave and the sound wave can be shortened, the measurement error of the component concentration can be reduced. Further, by shortening the detection time difference, the component concentration measurement time can be shortened, and the burden on the subject can be reduced.

  In the component concentration measuring apparatus control method of the present invention, a first extreme value ratio calculating means for calculating a ratio of maximum values of pulse waves for two consecutive beats detected by the pulse wave detecting means is the first pulse wave. The ratio of the maximum value of the pulse waves for two consecutive beats detected in the sound wave detection procedure and the second pulse wave sound wave detection procedure is calculated, and when the calculated ratio is greater than 1.1 or less than 0.9 Sometimes, the pulse wave detecting means and the mixed light emitting means return to the first pulse wave sound wave detecting procedure, and the pulse wave detecting means and the first single light emitting means are changed to the second pulse wave sound wave detecting procedure. It is desirable to further include a first pulse wave confirmation procedure that returns and repeatedly measures the component concentration.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. In the present invention, the difference in blood volume is within a certain range, i.e., both of them are smaller than a certain reference value where the signal difference between the maximum value and the maximum value (or the minimum value-the minimum value) between two consecutive beats is smaller. It is possible to determine a state in which the blood volume can be regarded as substantially equal. Therefore, it is possible to detect both signals of [the differential sound wave generated by the first light and the second light] and [the sound wave generated by the second light] under the condition that the blood volume fluctuation difference is small.

  In the component concentration measuring apparatus control method of the present invention, except within the certain time from the time point of the first pulse wave sound wave detection procedure and within the certain time period from the other time point of the second pulse wave sound wave detection procedure. The pulse wave detection means detects the pulse wave within the predetermined time within the predetermined time from another time point at which the pulse wave of the subject has a predetermined value, and the other two of the different two wavelengths of light are detected. A second single light emitting means that emits light having a predetermined wavelength that is electrically intensity-modulated emits light of one wavelength within the predetermined time, and the sound wave detecting means emits a sound wave within the predetermined time. It is desirable to further have a third pulse wave sound wave detection procedure to detect.

  In the present invention, it is possible to obtain information for verifying the validity of the sound wave intensity acquired in the first and second pulse wave sound wave intensity integrating procedures by acquiring the sound wave intensity by the third pulse wave sound wave detecting procedure. It becomes.

  In the component concentration measuring apparatus control method of the present invention, the sound wave intensity integrating means sequentially integrates the sound waves detected within the predetermined time in the third pulse wave sound wave detection procedure to obtain other single sound wave intensity. It is desirable to further have a sound intensity integration procedure.

  In the sound wave intensity integration procedure, for example, the sound wave signals are integrated by an integration circuit, and the signal is averaged by a division circuit. The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also

  As described above, in the present invention, by acquiring the sound wave intensity by the sound wave intensity integration procedure, it is possible to obtain the specific information necessary for verifying the validity of the sound wave intensity and verify the validity of the sound wave intensity.

  In the component concentration measuring apparatus control method of the present invention, the absolute value of the difference between the single sound wave intensity acquired in the second pulse wave sound wave intensity integrating procedure and the other single sound wave intensity acquired in the sound wave intensity integrating procedure And when the ratio calculated by the sound wave intensity ratio calculating means for calculating the ratio between the calculated absolute value and the mixed sound wave intensity acquired in the first pulse wave sound wave intensity integrating procedure is greater than 1.05 or 0 ..95, the pulse wave detecting means and the mixed light emitting means return to the first pulse wave sound wave detecting procedure, and the pulse wave detecting means and the first single light emitting means are the second pulse wave. It is desirable to further have a sound wave intensity confirmation procedure for returning to the sound wave detection procedure and repeatedly measuring the component concentration.

  In the present invention, [the differential sound wave signal between the sound wave generated by the first light and the sound wave generated by the second light] and [the sound wave signal generated by the first light]-[the sound wave signal generated by the second light] ] If the difference is large, repeat the measurement. Therefore, in the present invention, the validity of the mixed sound wave intensity and the single sound wave intensity acquired in the first and second pulse wave sound wave intensity integration procedures can be verified, and the measurement accuracy of the component concentration can be improved.

  In the component concentration measurement apparatus control method of the present invention, the predetermined time is set to be within one cycle of the pulse wave detected by the pulse wave detection unit, and the pulse wave detection unit detects three consecutive beats of the pulse wave of the subject. Minute is detected for each beat in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure, and the mixed light emitting means is configured to detect the first pulse wave sound wave detection procedure. The two single-wavelength light corresponding to the three beats is electrically intensity-modulated by a signal having the same frequency and opposite phase, and the first single light emitting means detects the second pulse wave sound wave. Corresponding to the three beats in the procedure, the light of a predetermined wavelength is electrically intensity-modulated and emitted, and the second single light emitting means outputs the three beats in the third pulse wave sound wave detection procedure. In response to the above, light of another predetermined wavelength is electrically modulated and emitted, It is desirable that the sound wave detecting means detects each sound wave corresponding to the three beats in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure. .

  In the present invention, since the difference in sound wave detection time is reduced, the accuracy of the verification result of the validity of the mixed sound wave intensity and the single sound wave intensity acquired in the first and second pulse wave sound wave intensity integrating procedures can be improved.

  In the component concentration measuring device control method of the present invention, a second extreme value ratio calculating means for calculating a ratio of the maximum value of any two beats of the pulse waves for three consecutive beats detected by the pulse wave detecting means. , The maximum value of any two beats among the three consecutive pulse waves detected in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure. When the ratio is calculated and the calculated ratio is greater than 1.1 or less than 0.9, the pulse wave detection means and the mixed light emission means return to the first pulse wave sound wave detection procedure and the pulse It is desirable that the wave detecting means and the first single light emitting means further include a second pulse wave confirmation procedure for returning to the second pulse wave sound wave detecting procedure and repeatedly measuring the component concentration.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. In the present invention, the difference in blood volume is within a certain range, i.e., both of them are smaller than a certain reference value where the signal difference between the maximum value and the maximum value (or the minimum value-the minimum value) between two consecutive beats is smaller. It is possible to determine a state in which the blood volume can be regarded as substantially equal. Therefore, any two signals of [differential sound wave generated by the first light and second light], [sound wave generated by the second light] or [sound wave generated by the first light] It can be detected under conditions where the variation difference is small.

  In the component concentration measurement apparatus control method of the present invention, in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure, the pulse wave detection means is the mixed light emitting means. A pulse wave is detected from a sound wave generated from the subject by light emitted from the first single light emitting means or the second single light emitting means, and the mixed light emitting means and the first single light emitting are detected. It is desirable to detect a pulse wave from the reflected light from the subject of the light emitted from the means or the second single light emitting means, or to detect the pulse wave by an electrocardiograph or a plethysmograph.

  In the present invention, the pulse wave of the subject can be detected by an electrocardiograph or a plethysmograph. Further, by detecting the pulse wave by the reflected light from the subject, the influence of electrical noise can be reduced and the detection accuracy of the pulse wave can be improved. Further, in the hemoglobin absorption band having a wavelength of 800 nm, when not only the absorption of blood but also the influence of blood scattering occurs, the change in blood volume is changed to the mixed light emitting means, the first single light emitting means, or the second single light. If the pulse wave is detected by the sound wave generated from the subject by the light emitted from the emitting means, only the absorption of blood can be detected, so that the accuracy is high.

  In the component concentration measuring device control method of the present invention, it is desirable that the wavelength of the two wavelengths is the wavelength of the two wavelengths of light, wherein the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by water. .

  In the present invention, the influence of the absorption of water is reduced by setting the wavelength of the two wavelengths to a wavelength of the two wavelengths of light that is larger than the difference of the absorption exhibited by the water. Thus, the measurement accuracy of the component concentration measurement can be improved.

  In the component concentration measurement apparatus control method of the present invention, the wavelength of the predetermined one wavelength among the two wavelengths of light is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the other one wavelength is selected. It is desirable that the wavelength of light be a wavelength at which water exhibits absorption equivalent to that at the wavelength of the one light.

  In the present invention, a predetermined one wavelength of the two wavelengths of light is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the other one wavelength of light is the water of the one light. By setting the wavelength to the same absorption as that at the wavelength, the influence of water absorption can be reduced and the measurement accuracy of the component concentration measurement can be improved.

  In the component concentration measuring apparatus control method of the present invention, the wavelength of the two wavelengths is set to the wavelength of the two wavelengths of light, wherein the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by the other components. It is desirable.

  In the present invention, by setting the wavelength of two wavelengths of light to a wavelength of two wavelengths, the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by the other components. It is possible to improve the measurement accuracy of the component concentration measurement by reducing the influence of absorption.

  The component concentration measurement apparatus according to the present invention excludes a predetermined time from a time point when the pulse wave of the subject becomes a predetermined value and a predetermined value of the pulse wave of the subject and the predetermined time from the time point. Pulse wave detection means for detecting the pulse wave of the subject in each of the fixed time from another time point, and two different wavelengths of light in the fixed time from the time point by signals of the same frequency and opposite phase A mixed light emitting means that emits light after being intensity-modulated, and emits light having a predetermined wavelength of the two different wavelengths within the predetermined time from the other time point. A first single light emitting means, and a sound wave generated in the subject by light emitted from the mixed light emitting means within the predetermined time is detected within the predetermined time from the time point; and The light emitted from the single light emitting means within the predetermined time Ri wherein characterized in that it comprises a sound wave detecting means for detecting the waves generated by the object within the predetermined time from the other times, the.

In the present invention, the mixed light emitting means converts the light of two different wavelengths, that is, the wavelength of the first light and the wavelength of the second light into the absorbance characteristics of the component to be measured and the water according to the measurement principle described above. The wavelength λ ₁ and the wavelength λ ₂ selected from the above are set. Further, the mixed light emitting means emits each of the first light and the second light by electrically modulating the intensity with a signal having the same frequency and opposite phase. When the subject is irradiated with the first light and the second light emitted in this way, a sound wave is generated from the subject, and the sound wave detecting means detects the sound wave generated from the subject. Here, the sound wave measured by the sound wave detecting means is a difference sound wave between the first sound wave generated by the first light and the second sound wave generated by the second light.

  Further, the first single light emitting means modulates the intensity of the light having the same wavelength as that of the second light in the same manner as the second light and emits the light with the same intensity as that of the second light. When the subject is irradiated with the second light emitted in this manner, a sound wave is generated from the subject, and the sound wave detecting means detects the sound wave generated from the subject.

  Here, when the mixed light emitting means emits the first light and the second light, and when the first single light emitting means emits the second light, the pulse wave detecting means Detect pulse waves. The time for the mixed light emitting means to emit the first light and the second light, the time for the first single light emitting means to emit the second light, and the time for the pulse wave detecting means to detect the pulse wave are as follows: Both are within a certain time from the time when the pulse wave of the subject becomes a predetermined value, and are set to a certain time triggered by the predetermined value of the pulse wave of the subject.

  Here, the predetermined value serving as a trigger for the pulse wave may be any value of the pulse wave, but is preferably an extreme value (either a maximum value or a minimum value) of the pulse wave. Since integration can be performed without straddling within an integration time within one beat, the component concentration can be calculated accurately even with several beats (two or more beats). Further, since the component concentration is measured in the time of several beats of the pulse wave, the measurement interval can be shortened. Furthermore, since the time is short, the fluctuation of the pulse interval can be reduced, and the calculation accuracy of the component concentration can be improved.

  As described above, in the present invention, the pulse wave is detected by the pulse wave detection means using the predetermined value of the pulse wave as a trigger, and the first light and / or the second light is output by the mixed light emission means and the single light emission means. The pulse wave and the sound wave when the blood volume due to the pulsation is relatively the same can be detected by emitting the above light and detecting the sound wave by the sound wave detecting means. Therefore, normalization of the sound wave intensity described later can be performed from the detected pulse wave and sound wave, and the influence of the change in blood flow due to pulsation on the sound wave intensity can be reduced and the component concentration can be accurately measured.

  In the component concentration measuring apparatus of the present invention, the pulse waves detected by the pulse wave detecting means are sequentially integrated within the predetermined time from the time point to obtain a pulse wave integrated value, and the pulse wave values from the other time points are acquired. Pulse wave integration means for sequentially integrating pulse waves detected by the pulse wave detection means within a predetermined time to obtain other pulse wave integrated values, and from the mixed light emitting means within the predetermined time from the time point The sound waves generated by the two wavelengths of light and detected by the sound wave detecting means are sequentially integrated to obtain a mixed sound wave intensity, and the first single light is emitted within the predetermined time from the other time point. It is desirable to further include sound intensity integrating means for sequentially accumulating the magnitudes of sound waves generated by light of one wavelength from the means and detected by the sound wave detecting means to obtain a single sound intensity.

  The pulse wave integrating means and the sound wave intensity integrating means are one specific means for normalizing the sound wave intensity described later. Here, in order to integrate the pulse wave and the sound wave, for example, the pulse wave signal and the sound wave signal are integrated by the integrating circuit, and the signal is averaged by the dividing circuit. The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also

  As described above, in the present invention, by obtaining the pulse wave integrated value by the pulse wave integrating unit and the sound wave intensity by the sound wave intensity integrating unit, specific information necessary for normalization of the sound wave intensity is obtained and the sound wave intensity is obtained. Standardization is possible.

  In the component concentration measuring apparatus of the present invention, the pulse wave integrated value obtained by the pulse wave integrating means within the predetermined time from the time point, and the pulse wave integrating means acquired by the pulse wave integrating means within the fixed time from the other time point. Another pulse wave integrated value, a mixed sound wave intensity obtained by the sound wave intensity integrating means within the predetermined time from the time point, and a single wave within the fixed time from the other time point obtained by the sound wave intensity integrating means It is desirable to further include a component concentration calculation means for calculating the component concentration to be measured from the sound wave intensity.

  In the present invention, the component concentration can be calculated by the normalized concentration of sound wave described later by the component concentration calculating means.

  In the component concentration measuring apparatus of the present invention, the component concentration calculating means includes a mixed sound wave intensity standard value obtained by dividing the mixed sound wave intensity by the pulse wave integrated value, and the single sound wave intensity as the other pulse wave integrated value. It is desirable to calculate the component concentration from the ratio of the divided single sound intensity standard values.

  In the present invention, the mixed sound wave intensity is normalized by dividing the mixed sound wave intensity by the pulse wave integrated value. Further, the single sound wave intensity is normalized by dividing the single sound wave intensity by the pulse wave integrated value. Here, the pulse wave integrated value that divides the mixed sound wave intensity is the integrated value of the sound wave and pulse wave detected at the same time as the sound wave generated by the mixed light, and the pulse wave integrated value that divides the single sound wave intensity is The integrated value of the pulse wave detected at the same time as the sound wave generated by the single light. In the present invention, in order to detect a pulse wave and a sound wave when the blood volume due to pulsation is relatively the same, by dividing the sound wave intensity by the pulse wave integrated value, a standard value is obtained and the sound wave intensity due to the pulsation is obtained. The influence of can be reduced. Therefore, in the present invention, since the component concentration is calculated by normalizing the sound wave intensity, a highly accurate calculation result can be obtained.

  In the component concentration measuring apparatus of the present invention, the predetermined time is set to be within one cycle of the pulse wave detected by the pulse wave detecting means, and the pulse wave detecting means calculates two consecutive beats of the pulse wave of the subject. One beat is detected within the predetermined time from the time point and the other time point, and the mixed light emitting means outputs light of two different wavelengths within the predetermined time from the time point corresponding to the two beats. The first single light emitting means emits a predetermined one within the predetermined time from the other time corresponding to the two beats, and the intensity is modulated with an electric signal having an opposite phase at the same frequency. It is desirable that the light of the wavelength is electrically intensity-modulated and emitted, and the sound wave detection unit detects each sound wave corresponding to the two beats.

  In the present invention, since the detection time difference between the pulse wave and the sound wave can be shortened, the measurement error of the component concentration can be reduced. Further, by shortening the detection time difference, the component concentration measurement time can be shortened, and the burden on the subject can be reduced.

  The component concentration measuring apparatus of the present invention further includes first extreme value ratio calculating means for calculating a ratio of maximum values of the pulse waves for two consecutive beats detected by the pulse wave detecting means. When the ratio calculated by the extreme value ratio calculating means is larger than 1.1 or smaller than 0.9, the pulse wave detecting means, the mixed light emitting means and the first single light emitting means have component concentrations. It is desirable to measure repeatedly.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. In the present invention, since the signal difference between the maximum value and the maximum value (or the minimum value and the minimum value) between two consecutive beats is smaller than a certain reference, the blood volume difference is within a certain range, that is, It is possible to determine a state in which both blood volumes can be regarded as substantially equal. Therefore, it is possible to detect both signals of [the differential sound wave generated by the first light and the second light] and [the sound wave generated by the second light] under the condition that the blood volume fluctuation difference is small.

  In the component concentration measuring apparatus of the present invention, the pulse wave of the subject becomes a predetermined value, and within the predetermined time from the other time except for the predetermined time from the time and the fixed time from the other time And further comprising a second single light emitting means for electrically modulating the intensity of another predetermined one of the two different wavelengths of light, and emitting the pulse wave from the time point. Detecting a pulse wave within the certain time from the other time except the certain time and within the certain time from the other time, and the sound wave detecting means It is desirable to detect a sound wave by light of one wavelength from the second single light emitting means within the certain time from the other time except for the certain time from another time.

  In the present invention, there is further provided a second single light emitting means, and by detecting the sound wave by the sound wave detecting means, the validity of the sound wave intensity acquired within a certain time from the time point and within a certain time from the other time point is determined. It becomes possible to acquire information for verifying the performance.

  In the component concentration measuring apparatus according to the present invention, the sound wave intensity integrating means includes the sound wave intensity integrating means within the certain time from the other time except the certain time from the time and the certain time from the other time. It is desirable that the intensity of the sound wave generated by light of one wavelength from the two single light emitting means and detected by the sound wave detecting means is sequentially integrated to obtain another single sound intensity.

  The sound wave intensity integrating means, for example, integrates sound wave signals by an integrating circuit and performs signal averaging processing by a dividing circuit. The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also

  As described above, in the present invention, by acquiring another single sound wave intensity by the sound wave intensity integrating means, specific information necessary for verifying the validity of the sound wave intensity is obtained and the validity of the sound wave intensity is verified. It becomes possible.

  In the component concentration measuring apparatus of the present invention, the absolute value of the difference between the single sound wave intensity acquired by the sound wave intensity integrating means and the other single sound wave intensity is calculated, and the calculated absolute value and the sound wave intensity When the ratio calculated by the sound wave intensity ratio calculating unit is greater than 1.05 or less than 0.95, the sound wave intensity ratio calculating unit further calculates a ratio with the mixed sound wave intensity acquired by the integrating unit. In addition, it is desirable that the pulse wave detecting means, the mixed light emitting means, and the first single light emitting means repeatedly measure the component concentration.

  In the present invention, [the differential sound wave signal between the sound wave generated by the first light and the sound wave generated by the second light] and [the sound wave signal generated by the first light]-[the sound wave signal generated by the second light] ] If the difference is large, repeat the measurement. Therefore, in the present invention, the validity of the mixed sound wave intensity acquired within a certain time from the above time point and the single sound wave intensity obtained within the certain time period from the other time point is verified to increase the measurement accuracy of the component concentration. Can be improved.

  In the component concentration measuring apparatus of the present invention, the predetermined time is set to be within one cycle of the pulse wave detected by the pulse wave detecting means, and the pulse wave detecting means takes three consecutive beats of the pulse wave of the subject. One beat at a time from the time point, within the time period from the other time point, and within the time period from the other time point except the time point from the time point and the other time point The mixed light emitting means detects and emits light of two different wavelengths corresponding to the three beats within the predetermined time from the time point by electrically modulating the intensity with signals of the same frequency and opposite phase. The first single light emitting means emits light having a predetermined wavelength that is electrically intensity-modulated and emitted within the predetermined time from the other time corresponding to the three beats, and the second The single light emitting means corresponds to the three beats and the time point and the The predetermined one wavelength of light other than the predetermined time from the point in time is excluded from the other predetermined point in time, and the predetermined one wavelength of light is intensity-modulated and emitted. Correspondingly, it is desirable to detect each sound wave.

  In the present invention, since the difference in sound wave detection time is small, the verification result of the validity of the mixed sound wave intensity acquired within a certain time from the time point and the single sound wave intensity obtained within a certain time period from the other time point Accuracy can be improved.

  In the component concentration measuring apparatus of the present invention, the second extreme value ratio calculating means for calculating the ratio of the maximum value of any two beats of the pulse waves for three consecutive beats detected by the pulse wave detecting means is further provided. And when the ratio calculated by the second extreme value ratio calculating means is larger than 1.1 or smaller than 0.9, the pulse wave detecting means, the mixed light emitting means, and the first single light The emitting means desirably measures the component concentration repeatedly.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. In the present invention, the difference in blood volume is within a certain range, i.e., both of them are smaller than a certain reference value where the signal difference between the maximum value and the maximum value (or the minimum value-the minimum value) between two consecutive beats is smaller. It is possible to determine a state in which the blood volume can be regarded as substantially equal. Therefore, any two signals of [differential sound wave generated by the first light and second light], [sound wave generated by the second light] or [sound wave generated by the first light] It can be detected under conditions where the variation difference is small.

  In the component concentration measuring apparatus of the present invention, the pulse wave detecting means is generated from the subject by light emitted from the mixed light emitting means, the first single light emitting means, or the second single light emitting means. A pulse wave is detected from a sound wave, and a pulse wave is detected from reflected light at the subject of light emitted from the mixed light emitting means, the first single light emitting means or the second single light emitting means, Or it is desirable to detect a pulse wave with an electrocardiograph or a plethysmograph.

  In the present invention, the pulse wave of the subject can be detected by an electrocardiograph or a plethysmograph. Further, by detecting the pulse wave by the reflected light from the subject, the influence of electrical noise can be reduced and the detection accuracy of the pulse wave can be improved. Further, in the hemoglobin absorption band having a wavelength of 800 nm, when not only the absorption of blood but also the influence of blood scattering occurs, the change in blood volume is changed to the mixed light emitting means, the first single light emitting means, or the second single light. If the pulse wave is detected by the sound wave generated from the subject by the light emitted from the emitting means, only the absorption of blood can be detected, so that the accuracy is high.

  In the component concentration measuring apparatus of the present invention, it is desirable that the wavelength of the two wavelengths is the wavelength of the two wavelengths of light, wherein the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by water.

  In the present invention, the influence of the absorption of water is reduced by setting the wavelength of the two wavelengths to a wavelength of the two wavelengths of light that is larger than the difference of the absorption exhibited by the water. Thus, the measurement accuracy of the component concentration measurement can be improved.

  In the component concentration measuring apparatus of the present invention, the wavelength of the predetermined one wavelength of the two wavelengths of light is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the other one wavelength of light is measured. It is desirable that the wavelength be a wavelength at which water exhibits absorption equal to that of the one light.

  In the present invention, a predetermined one wavelength of the two wavelengths of light is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the other one wavelength of light is the water of the one light. By setting the wavelength to the same absorption as that at the wavelength, the influence of water absorption can be reduced and the measurement accuracy of the component concentration measurement can be improved.

  In the component concentration measuring apparatus of the present invention, the wavelength of the two wavelengths of light may be a wavelength of two wavelengths of light that is larger in the difference in absorption exhibited by the component to be measured than the difference in absorption exhibited by the other components. desirable.

  In the present invention, by setting the wavelength of two wavelengths of light to a wavelength of two wavelengths, the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by the other components. It is possible to improve the measurement accuracy of the component concentration measurement by reducing the influence of absorption.

  The non-invasive component concentration measuring apparatus and component concentration measuring apparatus control method of the present invention can reduce the influence of the pulsation of the subject on the sound wave generated in the subject and improve the measurement accuracy of the component concentration. it can.

  Embodiments of the present invention will be described with reference to the accompanying drawings.

  The following embodiment is an example of the configuration of the present invention, and is an embodiment in the case where a component concentration is measured by a finger of a human body as a subject, but the present invention is limited to the following embodiment is not. Further, in FIG. 3 showing the configuration of the component concentration measuring apparatus according to the following embodiment, a part that can be realized by a known technique such as a power source is not shown.

  A component concentration measuring apparatus according to this embodiment will be described.

  FIG. 3 shows a schematic configuration diagram of a component concentration measuring apparatus according to the present embodiment.

  In FIG. 3, the component concentration measuring apparatus 10 includes a pulse wave sensor 115 as a part of the pulse wave detecting means, an oscillator 101 as a part of the mixed light emitting means and the first and second single light emitting means, and a drive circuit. 102, 180 ° phase shift circuit 104, drive circuit 105, first light source 103 and second light source 106, sound wave detection unit 111 as part of sound wave detection means, filter 112 and phase detection amplification unit 113, component concentration calculation A component concentration calculation unit 114 is provided as a means. Further, in the present embodiment, the first light from the first light source 103 and the second light from the second light source 106 are irradiated to the same location of the subject 2 in order to irradiate the first light from the first light source 103. In order to increase the transmission efficiency of sound waves generated in the subject 2 between the light combining unit 107 for combining the first light and the second light from the second light source 106 and the subject 2 and the sound wave detecting unit 111 The acoustic matching material 110 is provided.

  The oscillator 101 outputs a modulation signal for intensity-modulating light of two wavelengths output from the first light source 103 and the second light source 106. The 180 ° phase shift circuit 104 inverts one of the modulation signals from the oscillator 101 and outputs it.

  The drive circuit 102 drives the first light source 103 based on the modulation signal from the oscillator 101. The drive circuit 105 drives the second light source 106 based on the modulation signal inverted by the 180 ° phase shift circuit 104. The first light source 103 modulates the intensity of one of the two different wavelengths of light with a signal from the drive circuit 102 and outputs the intensity of the other light by the signal from the drive circuit 105. Modulate and output. As a result, the first light source 103 and the second light source 106 can output the light of two different wavelengths that are electrically intensity-modulated with signals of the same frequency and opposite phase. In addition, if the emission of light from either the first light source 103 or the second light source 106 is stopped, the first light source 103 or the second light source 106 has a predetermined one of two different wavelengths of light. Only light having a wavelength can be emitted.

  Here, for example, a semiconductor laser can be applied to the first light source 103 and the second light source 106, and the difference in absorption exhibited by the components whose measurement targets are two wavelengths of light is water. It is desirable that the wavelength of the two wavelengths be larger than the difference in absorption exhibited. In addition, the wavelength of each of the first light source 103 and the second light source 106 is set such that the wavelength of one light exhibits a characteristic absorption by the component to be measured, and the wavelength of the other light is set by water. It can also be set to a wavelength that exhibits absorption equal to that of one of the wavelengths of light. Furthermore, the wavelength of the two wavelengths of light can be set to the wavelength of the two wavelengths of light, where the difference in absorption exhibited by the component to be measured is greater than the difference in absorption exhibited by the other components. As a result, it is possible to improve the measurement accuracy of the component concentration measurement by reducing the influence of absorption by components other than water and components to be measured. Here, when the component to be measured is glucose or cholesterol, the concentration of glucose or cholesterol can be measured with high accuracy by irradiating with a wavelength indicating characteristic absorption of glucose or cholesterol. The semiconductor lasers as the first light source 103 and the second light source 106 can change the wavelength of light generated by heating or cooling with a heater or a Peltier element.

  In addition, the drive circuits 102 and 105 combine the two-wavelength light from the first light source 103 and the second light source 106 into one light beam and irradiate the water with water so that the pressure of the sound wave generated becomes zero. It is desirable to adjust the relative intensity of each of the two wavelengths of light. The pressure of the sound wave generated by irradiating the subject with light of two different wavelengths corresponds to the total absorption in the state where the component of the measurement target generated in the subject and water are mixed as described above. The difference between the pressure of the sound wave to be generated and the pressure of the sound wave generated by only the water in which the other one wave of light occupies most of the subject is detected. Therefore, if the relative intensities of two different wavelengths of light are calibrated so that the difference value becomes zero, the component concentration measurement accuracy can be improved.

  In addition, it is desirable that the drive circuits 102 and 105 perform modulation at the same frequency as the resonance frequency related to detection of sound waves generated by light of two wavelengths from the first light source 103 and the second light source 106. The sound wave detection unit 111 measures the sound wave by modulating the modulation frequency for electrically modulating the intensity of each of the two different wavelengths of light at the same frequency as the resonance frequency related to the detection of the sound wave generated in the subject. Measure sound waves for light of two different wavelengths selected in consideration of the nonlinearity related to the absorption coefficient, and eliminate the influence of many parameters that are difficult to keep constant from these measured values. Sound waves generated in the specimen can be detected.

  In the present embodiment, a rectangular wave signal is output from the oscillator 101, and the first light source 103 and the second light source 106, which are the two semiconductor laser light sources, are connected to each other at the same frequency and in opposite phases. To modulate directly. In this way, by directly modulating each of the two semiconductor laser light sources with rectangular wave signals having the same frequency and opposite phases, it is possible to generate light of two different wavelengths and simultaneously modulate them, thereby simplifying the device configuration. Can be

  The multiplexing unit 107 combines the light from the first light source 103 and the light from the second light source 106 by, for example, a half mirror, and emits the modulated light 120 toward the subject 2.

  The sound wave detection unit 111 detects the sound wave generated in the subject 2 by the light emitted from the first light source 103 and / or the second light source 106 via the multiplexing unit 107 via the acoustic matching material 110, An electrical signal proportional to the amplitude of the sound wave is output. The filter 112 removes high frequency noise from the electrical signal from the sound wave detection unit 111 and outputs the result. The phase detection amplification unit 113 synchronously detects the electrical signal from the filter using the modulation signal from the oscillator 101, and outputs an electrical signal proportional to the sound pressure. In this manner, the sound wave detection unit 111 and the phase detection amplification unit 113 measure the magnitude of the sound wave. Thus, by detecting the sound wave by synchronous detection synchronized with the modulation frequency, the sound wave can be detected with high accuracy.

  The pulse wave sensor 115 detects the pulse wave of the subject 2. The pulse wave sensor 115 detects a pulse wave from a sound wave generated in the subject 2 by light emitted from the first light source 103 and / or the second light source 106, and detects the first light source 103 and / or the second light source 103. It is desirable to detect a pulse wave from light reflected from the subject 2 emitted from the light source 106, or to detect a pulse wave by an electrocardiograph (not shown) or a plethysmograph (not shown). The detection of the pulse wave from the reflected light, the detection of the pulse wave by the electrocardiograph, and the detection of the pulse wave by the plethysmograph can be realized by well-known techniques.

  As described above, the component concentration measuring apparatus 10 can detect the pulse wave of the subject 2 with an electrocardiograph (not shown) or a plethysmograph (not shown). Further, the pulse wave is detected by detecting the pulse wave by the reflected light from the subject 2 of the light emitted from the first light source 103 and / or the second light source 106, thereby reducing the influence of electrical noise. Accuracy can be improved.

  In addition, as described with reference to FIG. 2, the magnitude of the sound wave generated in the subject 2 by the light emitted from the first light source 103 and / or the second light source 106 increases or decreases in synchronization with the pulse. Therefore, if the sound wave detection unit 111 detects a sound wave synchronized with the pulse, the pulse wave of the subject 2 can be detected. In the hemoglobin absorption band having a wavelength of 800 nm, when not only blood absorption but also blood scattering occurs, a change in blood volume is detected by light emitted from the first light source 103 and / or the second light source 106. If the pulse wave is detected by the sound wave generated from 2, only the absorption of blood can be detected, so that the accuracy is good. As for the wavelength band, if a sound wave of one wavelength is detected among the two wavelengths used for measurement, the increase or decrease of water corresponding to the blood volume may be detected.

The component concentration calculation unit 114 stores the pulse wave, the two-wavelength light emitted at different times, and the sound wave size of the one-wavelength light, respectively, and calculates the component concentration from the previously prepared equation (1). calculate. Thus, by having the component concentration calculation unit 114, it is possible to calculate the component concentration of the measurement target by executing the calculation of (s ₁ −s ₂ ) ÷ s ₂ in accordance with the measurement principle described above.

  Here, a specific function of each part by the operation of the component concentration measuring apparatus 10 of the present embodiment will be described.

  FIG. 4 shows a schematic diagram of a pulse wave and a magnitude of a sound wave generated in synchronization with the pulse wave.

In FIG. 4, the magnitude 50 of the sound wave generated in the subject 2 by light of two different wavelengths (wavelengths λ ₁ and λ ₂ ) from the first light source 103 and the second light source 106 in FIG. As shown at a fixed time τ1 at time t2, it indicates that the pulse wave 21 increases or decreases in synchronization. In FIG. 4, the magnitude 51 of the sound wave generated in the subject 2 by the light having a predetermined wavelength (wavelength λ ₂ ) from the second light source 106 in FIG. 3 is a certain time τ 1 from time t 3 to time t 4. As shown in FIG. 4, the increase / decrease is synchronized with the pulse wave 21.

  In the present embodiment, the pulse wave sensor 115 as the pulse wave detecting means in FIG. 3 is within a certain time τ1 from the time point t1 when the pulse wave 21 of the subject shown in FIG. The pulse wave 21 of the subject is detected at a predetermined value of the wave 21 and within a certain time τ1 from the other time t3 except for the certain time τ1 from the time t1. That is, the pulse wave sensor 115 in FIG. 3 detects the pulse waves 21 at two different times in FIG. 4 (a constant time τ1 from time t1 to time t2 and a constant time τ1 from time t3 to time t4).

  Further, the first light source 103 and the second light source 106 as the mixed light emitting means in FIG. 3 are configured to electrically output two different wavelengths of light with the same frequency and opposite phase signals within a predetermined time τ1 from the time point t1. Emitted after intensity modulation. That is, the first light source 103 and the second light source 106 in FIG. 3 emit light of two different wavelengths from the time t1 to the time t2 for a certain time τ1 among the two different times in FIG.

  Further, the second light source 106 as the first single light emitting means in FIG. 3 electrically modulates the intensity of a predetermined one wavelength of two different wavelengths within a certain time τ1 from the time point t2. And exit. That is, the second light source 106 in FIG. 3 emits light of a predetermined wavelength at a certain time τ1 from time t3 to time t4 among two different times in FIG.

  In the present embodiment, regarding the emission of light as a function of the mixed light emission means and the first single light emission means, the emission of light of two different wavelengths from the first light source 103 and the second light source 106 is first performed. The light of the predetermined one wavelength from the second light source 106 is later emitted, but the light of the predetermined one wavelength from the second light source 106 is first emitted before the first light source 103 and the second light source. The two different wavelengths of light from 106 may be emitted later.

  In addition, the sound wave detection unit 111 as the sound wave detection unit in FIG. 3 generates sound waves generated in the subject 2 by light of two different wavelengths emitted from the first light source 103 and the second light source 106 within a predetermined time τ1. The phase detection and amplification unit 113, which detects within a predetermined time τ1 from the time t1, measures the amplitude of the sound wave 50, and receives light of a predetermined wavelength emitted from the second light source 106 within the predetermined time τ1. The sound wave generated in the sample 2 is detected within a certain time τ1 from another time point t3, and the phase detection amplification unit 113 measures the sound wave as a magnitude 51. That is, the sound wave detection unit 111 in FIG. 3 detects sound waves at two different times in FIG. 4 (a certain time τ1 from time t1 to time t2 and a certain time τ1 from time t3 to time t4).

  Here, the predetermined value of the pulse wave at the time points t1 and t3, that is, the predetermined value that triggers the pulse wave 21, may take any value of the pulse wave 21, but the pole of the pulse wave 21 may be taken. It is desirable to set a value (either one of a maximum value or a minimum value). In FIG. 4, the maximum value of the pulse wave 21 is set to a predetermined value. In this way, by setting the maximum value of the pulse wave 21 to a predetermined value, it is possible to integrate without crossing the beat within the integration time within one beat, so even a few beats (with two or more beats) can be accurately performed. Calculation is possible. Moreover, since the component concentration is measured in the time of several beats of the pulse wave 21, the measurement interval can be shortened. Furthermore, since the time is short, the fluctuation of the pulse interval can be reduced, and the calculation accuracy of the component concentration can be improved.

  As described above, the component concentration measuring apparatus 10 according to the present embodiment detects the pulse wave 21 using the pulse wave sensor 115 as a trigger for the predetermined value of the pulse wave 21 of the subject in FIG. 103 and / or the second light source 106 emits the first light and / or the second light, and the sound wave detection unit 111 detects the sound wave, whereby the pulse wave when the blood volume is relatively the same. 21 and sound waves can be detected and measured as sound wave sizes 50 and 51. Therefore, the component concentration measurement apparatus 10 according to the present embodiment can normalize the sound wave intensity, which will be described later, from the detected pulse wave 21 and sound wave magnitudes 50 and 51, and a change in blood flow due to pulsation gives the sound wave intensity. The component concentration can be accurately measured with less influence.

  The component concentration calculation unit 114 as the component concentration calculation unit in FIG. 3 has functions as a pulse wave integration unit and a sound wave intensity integration unit. Then, the component concentration calculation unit 114 sequentially accumulates the pulse waves 21 detected by the pulse wave sensor 115 within a certain time τ1 from the time point t1 shown in FIG. The pulse waves 21 detected by the pulse wave sensor 115 are sequentially integrated within a certain time τ1 from t3 to obtain another integrated pulse wave value. In addition, the component concentration calculation unit 114 is a magnitude of the sound wave generated by the two-wavelength light from the first light source 103 and the second light source 106 and detected by the sound wave detection unit 111 within a certain time τ1 from the time point t1. 50 is sequentially accumulated to obtain a mixed sound wave intensity, and the magnitude of the sound wave generated by one wavelength of light from the second light source 106 and detected by the sound wave detection unit 111 within a predetermined time τ1 from another time point t3. 51 are sequentially integrated to obtain a single sound wave intensity.

  The above integration is performed, for example, by integrating a pulse wave signal and a sound wave signal by an integration circuit (not shown) and averaging the signals by a division circuit (not shown). The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also Here, the averaging process in the integrating circuit and the dividing circuit may be performed in real time, but may be performed at a time different from the separately stored pulse wave and magnitude of the sound wave and detection of the sound wave.

  As described above, the component concentration measuring apparatus 10 according to the present embodiment obtains specific information necessary for normalization of the sound wave intensity by obtaining the pulse wave integrated value and the sound wave intensity by the component concentration calculating unit 114, thereby obtaining the sound wave. Strength standardization is possible.

  Further, the component concentration calculation unit 114 calculates the pulse wave integrated value within a certain time τ1 from the time point t1 in FIG. 4, the other pulse wave integrated value within the certain time τ1 from another time point t3, and the certain time from the time point t1. It has a function to calculate the component concentration to be measured from the mixed sound wave intensity within τ1 and the single sound wave intensity within a certain time τ1 from another time point t3, and the mixed sound wave intensity is divided by the integrated pulse wave value. It is desirable to calculate the component concentration from the ratio of the mixed sound wave intensity standard value and the single sound wave intensity standard value obtained by dividing the single sound wave intensity by another pulse wave integrated value.

The component concentration calculation unit 114 normalizes the mixed sound wave intensity by dividing the mixed sound wave intensity by the pulse wave integrated value. Further, the single sound wave intensity is normalized by dividing the single sound wave intensity by the pulse wave integrated value. Here, the pulse wave integrated value that divides the mixed sound wave intensity is the integrated value of the sound wave and pulse wave detected at the same time as the sound wave generated by the mixed light, and the pulse wave integrated value that divides the single sound wave intensity is The integrated value of the pulse wave detected at the same time as the sound wave generated by the single light. Then, the component concentration calculation unit 114 substitutes the normalized mixed sound wave intensity standard value into (s ₁ -s ₂ ) of the above-described equation (3), and sets the single sound wave intensity standard value of the above-described equation (3). The component concentration can be calculated by substituting for s ₁ .

  Thus, the component concentration measuring apparatus 10 according to the present embodiment divides the sound wave intensity by the pulse wave integrated value in order to detect the pulse wave and the sound wave when the blood volume due to pulsation is relatively the same. As a result, the standard value can be obtained and the influence of the pulsation on the sound wave intensity can be reduced. Therefore, since the component concentration measuring apparatus 10 according to the present embodiment calculates the component concentration by normalizing the sound wave intensity, it is possible to obtain an accurate calculation result.

  FIG. 5 is a schematic view showing another example of a pulse wave and the magnitude of a sound wave generated in synchronization with the pulse wave.

In FIG. 5, the magnitude 60 of the sound wave generated in the subject 2 by the light of two different wavelengths (wavelengths λ ₁ and λ ₂ ) from the first light source 103 and the second light source 106 in FIG. As shown at a constant time τ2 at time t6, the frequency increases or decreases in synchronization with the pulse wave 22. Further, in FIG. 5, the magnitude 61 of the sound wave generated in the subject 2 by the light having a predetermined wavelength (wavelength λ ₂ ) from the second light source 106 in FIG. 3 is a certain time τ 2 from time t 7 to time t 8. As shown in the figure, the increase / decrease in synchronization with the pulse wave 22 is shown. Further, in FIG. 5, the magnitude 62 of the sound wave generated in the subject 2 by another predetermined wavelength of light (wavelength λ ₁ ) from the first light source 103 in FIG. 3 is constant from time t9 to time t10. As shown at time τ2, it indicates that the pulse wave 22 increases or decreases in synchronization.

  In the present embodiment, the certain time τ2 is within one cycle of the pulse wave 22 detected by the pulse wave sensor 115 in FIG. 3 (from the maximum value (minimum value) in the pulse wave in FIG. 5 to the next maximum value (minimum value)). The pulse wave sensor 115 preferably detects two consecutive beats of the pulse wave 22 of the subject 2 one beat at a time τ2 from the time point t5 and another time point t7. . That is, the pulse wave sensor 115 in FIG. 3 detects the pulse wave 22 at a certain time τ2 from time t5 to time t6 and from a time t7 to time t8 among the three different times in FIG.

Also, the first light source 103 and the second light source 106 in FIG. 3 correspond to two different wavelengths of light (wavelength λ ₁₎ within a certain time τ 2 from time t 5 corresponding to two beats of the pulse wave 22 in FIG. , Λ ₂ ) is electrically intensity-modulated with a signal having the same frequency and opposite phase, and then emitted. That is, the first light source 103 and the second light source 106 in FIG. 3 emit light of two different wavelengths from time t5 to time t6 among the three different times in FIG.

3 corresponds to two beats of the pulse wave 22 of FIG. 5 and has a predetermined wavelength (wavelength) of two different wavelengths within a certain time τ2 from the time t7. λ ₂ ) is electrically intensity-modulated and emitted. That is, the second light source 106 in FIG. 3 emits light of a predetermined wavelength at a certain time τ2 from time t7 to time t8 among the three different times in FIG.

  In the present embodiment, regarding the emission of light as a function of the mixed light emission means and the first single light emission means, the emission of light of two different wavelengths from the first light source 103 and the second light source 106 is first performed. The light of the predetermined one wavelength from the second light source 106 is later emitted, but the light of the predetermined one wavelength from the second light source 106 is first emitted before the first light source 103 and the second light source. The two different wavelengths of light from 106 may be emitted later.

  Also, the sound wave detection unit 111 as the sound wave detection unit in FIG. 3 is detected by the subject 2 using light of two different wavelengths emitted from the first light source 103 and the second light source 106 within a predetermined time τ2 from the time point t5. The generated sound wave is detected within a certain time τ2 from time t5, and the phase detection amplification unit 113 measures the sound wave magnitude 60. The sound wave detection unit 111 detects a sound wave generated in the subject 2 by light having a predetermined wavelength emitted from the second light source 106 within a certain time τ2 within a certain time τ2 from another time point t7. The phase detection amplification unit 113 measures the sound wave magnitude 61. That is, the sound wave detection unit 111 in FIG. 3 detects sound waves at two different times in FIG. 5 (a certain time τ2 from time t5 to time t6 and a certain time τ2 from time t7 to time t8).

  By detecting the pulse wave 22 and the sound wave in this way, the component concentration measuring apparatus 10 according to the present embodiment can shorten the detection time difference between the pulse wave 22 and the sound wave, thereby reducing the measurement error of the component concentration. be able to. Further, by shortening the detection time difference, the component concentration measurement time can be shortened, and the burden on the subject 2 can be reduced.

  Further, in the present embodiment, the component concentration calculation unit 114 functions as a first extreme value ratio calculation unit that calculates the maximum value ratio of the pulse wave 22 for two beats of FIG. 5 detected by the pulse wave sensor 115. It is desirable that the component concentration measuring apparatus 10 repeatedly measures the component concentration when the ratio calculated by the component concentration calculating unit 114 is larger than 1.1 or smaller than 0.9.

  Although it is considered that the fluctuation of the continuous pulse wave 22 is small at rest, the pulsation may fluctuate rapidly due to body movements or external factors. The component concentration measuring apparatus 10 according to the present embodiment is configured so that the signal difference between the maximum value and the maximum value (or the minimum value and the minimum value) between two consecutive beats in FIG. It is possible to determine a state in which the volume difference is within a certain range, that is, a state in which the blood volumes of the two can be regarded as substantially equal. Therefore, it is possible to detect both signals of [the differential sound wave generated by the first light and the second light] and [the sound wave generated by the second light] under the condition that the blood volume fluctuation difference is small. Here, the determination of the extreme value of the pulse wave 22 can be realized by a known technique such as signal processing of the differential value of the waveform.

Further, the first light source 103 as the second single light emitting means in FIG. 3 has a predetermined value of the pulse wave 22 of the subject in FIG. 5 within a predetermined time τ2 from the time t5 and from another time t7. Within a certain time τ2 from another time t9 except within the certain time τ2, another predetermined wavelength of light (wavelength λ ₁ ) out of two different wavelengths is emitted after being electrically modulated, and pulsed. The wave sensor 115 detects the pulse wave 22 within a certain time τ2 from the time t9 other than the certain time τ2 from the time t5 and other than the certain time τ2 from the other time t7, and the sound wave detection unit 111 Within a certain time τ2 from the time t5 and within a certain time τ2 from the other time t9 except for the certain time τ2 from the other time t7, the sound wave by the light of one wavelength from the first light source 103 is detected and phased. The detection amplification unit 113 desirably measures the sound wave magnitude 62. . Here, in FIG. 5, pulse waves 22 for three consecutive beats are detected and the magnitudes 60, 61, and 62 of the sound waves generated corresponding thereto are shown, but the pulse wave sensor 115 and the sound wave detection unit 111 are shown. The pulse wave 22 and the sound wave may be detected at three different times.

  The component concentration measuring apparatus 10 according to the present embodiment emits light of another predetermined wavelength from the first light source 103, and detects the sound wave by the sound wave detection unit 111, and within a certain time τ2 from the time point t5 and It becomes possible to acquire information for verifying the validity of the sound wave intensity acquired within a certain time τ2 from another time point t7.

  Here, when the validity of the sound wave intensity is verified, the component concentration calculation unit 114 as the sound wave intensity integrating means excludes the fixed time period τ2 from the time point t5 and the fixed time period τ2 from another time point t7. The sound wave magnitude 62 generated by one wavelength light from the first light source 103 and detected by the sound wave detection unit 111 within a certain time τ2 from the time point t9 is sequentially accumulated and obtained as another single sound wave intensity. It is desirable to do.

  For example, the component concentration calculation unit 114 integrates the sound wave signal by an integration circuit (not shown), and performs an averaging process of the signal by a division circuit (not shown). The longer the integration time, the smaller the effect of random noise, so it is desirable to integrate over a period of 100 msec to several seconds, but when the influence of random noise is so small that it can be ignored, the measurement takes a short integration time of 1 msec. You can also Here, the averaging process in the integrating circuit and the dividing circuit may be performed in real time, but the separately stored sound wave intensity may be performed at a time different from the detection of the sound wave.

  Thus, the component concentration measurement apparatus 10 according to the present embodiment obtains specific information necessary for verification of the validity of the sound wave intensity by acquiring another single sound wave intensity by the component concentration calculating unit 114. Therefore, the validity of the sound wave intensity can be verified.

  When the validity of the sound wave intensity is verified, the component concentration calculation unit 114 receives the single sound wave intensity acquired by the component concentration calculation unit 114 (the sound wave within a certain time τ2 from time t7 to time t8 in FIG. 5). And the absolute value of the difference between the intensity of the single sound wave) and the other single sound wave intensity (the integrated value of the sound wave magnitude 62 within a predetermined time τ2 from time t9 to time t10 in FIG. 5). The sound wave intensity ratio calculation that calculates the ratio between the absolute value and the mixed sound wave intensity acquired by the component concentration calculation unit 114 (the integrated value of the sound wave size 60 within the fixed time τ2 from the time point t5 to the time point t6 in FIG. 5). It has a function as a means. The component concentration measuring apparatus 10 desirably repeatedly measures the component concentration when the ratio calculated by the component concentration calculation unit 114 is greater than 1.05 or less than 0.95.

  The component concentration measuring apparatus 10 in FIG. 3 includes [a differential sound wave signal between a sound wave generated by the first light and a sound wave generated by the second light] and [a sound wave signal generated by the first light]-[second When the difference between the sound wave signals generated by light is large, the measurement is performed again. Therefore, the component concentration measuring apparatus 10 according to the present embodiment has the mixed sound wave intensity acquired within the constant time τ2 from the time point t5 in FIG. 5 and the single sound wave intensity acquired within the constant time τ2 from the other time point t7. The validity can be verified and the measurement accuracy of the component concentration can be improved.

  Further, as in the present embodiment, the pulse wave 22 for three beats in FIG. 5 is detected, and light of two different wavelengths, light of a predetermined one wavelength, and other predetermined one wavelength corresponding to the three beats. Since the component concentration measuring apparatus 10 according to the present embodiment decreases the detection time difference between the pulse wave 22 and the sound wave by emitting the light and detecting the sound wave corresponding to three beats, the time t5 in FIG. It is possible to improve the accuracy of the verification result of the validity of the mixed sound wave intensity acquired within the predetermined time τ2 from the time point and the single sound wave intensity acquired at the constant time τ2 from the other time point t7.

  Further, in the present embodiment, the component concentration calculation unit 114 calculates the ratio of the maximum value of any two beats of the pulse waves 22 for three consecutive beats in FIG. 5 detected by the pulse wave sensor 115. It is desirable to further include a value ratio calculation means, and the component concentration measurement apparatus 10 desirably repeatedly measures the component concentration when the ratio calculated by the component concentration calculation unit 114 is greater than 1.1 or less than 0.9. .

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. The component concentration measuring apparatus 10 according to the present embodiment has a signal difference between a maximum value and a maximum value (or a minimum value and a minimum value) between any two beats among the three consecutive beats of the pulse wave of FIG. It is possible to determine a state in which the blood volume difference is within a certain range, that is, the blood volume of both can be regarded as substantially equal, from a position smaller than a certain standard. Therefore, any two signals of [differential sound wave generated by the first light and second light], [sound wave generated by the second light] or [sound wave generated by the first light] It can be detected under conditions where the variation difference is small. Here, the determination of the extreme value of the pulse wave 22 can be realized by a known technique such as signal processing of the differential value of the waveform. Further, “calculating the ratio of the maximum value of any two beats” does not necessarily mean that all three combinations of any two beats out of the three beats of the pulse wave are included. 10 is calculated by calculating the ratio of extreme values for all three combinations of two beats of the pulse wave for three beats, and the concentration of the component is assured that “the condition that the blood volume fluctuation difference is small” is assured. Calculation accuracy can be improved.

  Next, a control method of the component concentration measuring apparatus 10 according to the present embodiment will be described with reference to FIGS. 3, 4, and 5.

In the control method of the component concentration measuring apparatus 10 according to the present embodiment, the first light source 103 and the second light source 106 of the component concentration measuring apparatus 10 have different two wavelengths of light, that is, the first light wavelength and the first light. The wavelength of the light ₂ is set to a wavelength λ ₁ and a wavelength λ ₂ selected from the components to be measured of the subject 2 and the absorbance characteristics of water in accordance with the measurement principle described above. Then, the component concentration measuring apparatus 10 performs the following operation as the first pulse wave sound wave detection procedure. That is, the pulse wave sensor 115 of the component concentration measuring apparatus 10 detects the pulse wave 21 of the subject 2 within a certain time τ1 from the time point t1 when the pulse wave of the subject 2 becomes a predetermined value in FIG. The first light source 103 and the second light source 106 emit light of two different wavelengths that are electrically intensity-modulated with signals having the same frequency and opposite phase, and the sound wave detection unit 111 generates sound waves generated by the subject 2. And the phase detection amplification unit 113 measures the acoustic wave size as 50. Moreover, the following operation | movement is performed as a 2nd pulse wave sound wave detection procedure. That is, the pulse wave sensor 115 of the component concentration measuring apparatus 10 detects the pulse wave 22 of the subject 2 within a certain time τ1 from another time point t3 at which the pulse wave 21 of the subject in FIG. The second light source 106 electrically modulates and emits light having a predetermined wavelength, the sound wave detection unit 111 detects a sound wave generated in the subject 2, and the phase detection amplification unit 113 Measured as the size 51. Here, the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure may be performed before or after the procedure.

  Thus, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the pulse wave 21 is detected by using the predetermined value of the pulse wave 21 of FIG. 4 as a trigger by the first and second pulse wave sound wave detection procedures. In addition, by emitting the first light and / or the second light and detecting the sound wave, it is possible to detect the pulse wave and the sound wave when the blood volume due to the pulsation is relatively the same. Therefore, it is possible to normalize the sound wave intensity, which will be described later, from the detected pulse wave 21 and the sound wave, and the component concentration can be accurately measured with less influence on the sound wave intensity due to the change in blood flow due to pulsation.

  Note that the first light source 103 and the second light source 106 have two wavelengths of light having a difference in absorption between components whose measurement target is the wavelength of light having two wavelengths is larger than the difference in absorption exhibited by water. The wavelength of one light is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the wavelength of the other light is set to a wavelength at which water exhibits absorption equal to that at the wavelength of one light Alternatively, as described above, the difference in absorption exhibited by the component to be measured can be set to two wavelengths of light that are larger than the difference in absorption exhibited by the other components. is there. Moreover, the above-mentioned effect by this is naturally provided in the control method of the component concentration measuring apparatus 10 according to the present embodiment.

  In addition, the component concentration measuring apparatus 10 according to the present embodiment performs the following operation as the first pulse wave sound wave intensity integration procedure. That is, the component concentration calculation unit 114 in FIG. 3 sequentially accumulates the pulse wave 21 detected by the pulse wave sensor 115 within a certain time τ1 from the time point t1 in FIG. 4 in the first pulse wave sound wave detection procedure. Acquired as a value and detected by the sound wave detection unit 111 within a predetermined time τ1 from the time point t1, and sequentially obtained by mixing the intensity 50 of the sound wave generated in the subject 2 with light of two different wavelengths, and obtaining the mixed sound wave intensity. To do. Moreover, the following operation | movement is performed as a 2nd pulse wave sound wave intensity integration procedure. That is, the component concentration calculation unit 114 in FIG. 3 sequentially accumulates the pulse wave 21 detected by the pulse wave sensor 115 within a certain time τ1 from the time point t3 in FIG. 4 in the second pulse wave sound wave detection procedure. Obtained as a value and sequentially integrating the magnitude 51 of the sound wave generated in the subject 2 by light of a predetermined wavelength detected by the sound wave detection unit 111 within a predetermined time τ1 from the time point t3 to obtain a single sound wave intensity. get. Here, in the first pulse wave sound wave detection procedure, the component concentration calculation unit 114 may perform pulse wave integration in real time in the first pulse wave sound wave detection procedure simultaneously with the input of the pulse wave signal from the pulse wave sensor 115. Alternatively, the pulse wave signal may be stored in a memory and performed after the first pulse wave sound wave detection procedure. In addition, the component concentration calculation unit 114 may perform integration of the sound wave size in real time simultaneously with the input of the sound wave signal via the filter 112 and the phase detection amplification unit 113 from the sound wave detection unit 111, You may memorize | store in memory and may perform after a 1st pulse wave sound wave detection procedure. The same applies to the integration process of the component concentration calculation unit 114 in the second pulse wave sound wave detection procedure.

  The above-described first and second pulse wave sound wave intensity integration procedures are one specific procedure up to the standardization of sound wave intensity which will be described later. Thus, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the pulse wave integrated value and the sound wave intensity are obtained by the first and second pulse wave sound wave intensity integrating procedures, which is necessary for the standardization of the sound wave intensity. It is possible to standardize the sound intensity by obtaining specific information.

Further, the component concentration calculation unit 114 in FIG. 3 includes a pulse wave integrated value acquired in the first pulse wave sound wave intensity integrating procedure and a second pulse wave sound wave intensity integrating procedure, another pulse wave integrated value, a mixed sound wave intensity, and a single unit. It is desirable to further have a component concentration calculation procedure for calculating the component concentration from the single sound wave intensity. In this procedure, the component concentration calculation unit 114 has a sound wave size 50 within a certain time τ1 from time t1 to time t2 in FIG. The mixed sound wave intensity standard value obtained by dividing the mixed sound wave intensity that is the integrated value of the pulse wave by the pulse wave integrated value that is the integrated value of the pulse wave 21 within the constant time τ1 from the time point t1 to the time point t2, and the constant time period from the time point t3 to the time point t4. The single sound wave intensity obtained by dividing the single sound wave intensity, which is the integrated value of the sound wave magnitude 51 within τ1, by the other pulse wave integrated value, which is the integrated value of the pulse wave 21 within the predetermined time τ1 from time t3 to time t4. Calculate the component concentration from the ratio of the standard values It is desirable to. The component concentration calculation unit 114 substitutes the standardized mixed sound wave intensity standard value into (s ₁ −s ₂ ) of the above-described equation (3), and sets the single sound wave intensity standard value to s _{1 of the} above-described equation (3). The component concentration can be calculated by substituting for.

  Thus, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the component concentration can be calculated from the normalized sound wave intensity by the component concentration calculation procedure. In other words, in order to detect the pulse wave and sound wave when the blood volume due to pulsation is relatively the same, the standard value is obtained by dividing the sound wave intensity by the pulse wave integrated value, and the effect on the sound wave intensity due to pulsation Can be reduced. Therefore, in the present invention, since the component concentration is calculated by normalizing the sound wave intensity, a highly accurate calculation result can be obtained.

  Here, the predetermined value serving as the trigger of the pulse wave may be the time of any value of the pulse wave 21 in FIG. 4, but is the extreme value (either the maximum value or the minimum value) of the pulse wave 21. It is desirable. In FIG. 4, as described above, the maximum value of the pulse wave 21 is set to a predetermined value. In this way, by setting the maximum value of the pulse wave 21 to a predetermined value, it is possible to integrate without inter-beating within an integration time within one beat, so even a few beats (with two or more beats) can be accurately obtained. Can be calculated, and the measurement interval can be shortened. Further, since the time is short, the fluctuation of the pulse interval can be reduced, and the calculation accuracy of the component concentration can be improved.

  Further, as shown in FIG. 4, the predetermined time τ1 is set to be within one cycle of the pulse wave 21 detected by the pulse wave sensor 115 of FIG. 3, and the pulse wave sensor 115 is the continuous 2 of the pulse waves 21 of the subject 2. The beat is detected one beat at a time in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure, and the first light source 103 and the second light source 106 detect the pulse of FIG. The light of two different wavelengths corresponding to two beats of the wave is electrically intensity-modulated with a signal of the same phase and opposite phase and emitted, and the second light source 106 performs the second pulse wave sound wave detection procedure in FIG. Corresponding to two beats of the pulse wave, a predetermined wavelength of light is electrically intensity-modulated and emitted, and the sound wave detection unit 111 performs the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure. It is desirable to detect each sound wave corresponding to two beats of the pulse wave of FIG.

  In the control method of the component concentration measuring apparatus 10 according to the present embodiment, the pulse wave 21 for two consecutive beats and the sound wave corresponding thereto are detected, so that the difference in detection time between the pulse wave 21 and the sound wave can be shortened. Therefore, the measurement error of the component concentration can be reduced. Further, by shortening the detection time difference, the component concentration measurement time can be shortened, and the burden on the subject 2 can be reduced.

  Moreover, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the pulses for two consecutive beats of FIG. 4 detected by the pulse wave sensor 115 in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure. The ratio of the maximum value of the wave 21 is calculated, and when the calculated ratio is larger than 1.1 or smaller than 0.9, the component concentration is returned to the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure. It is desirable to further have a first pulse wave confirmation procedure for repeated measurement. Here, the first pulse wave confirmation procedure can be performed between the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the component concentration calculation procedure, and is performed after the component concentration calculation procedure. Also good.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. In the control method of the component concentration measuring apparatus 10 according to the present embodiment, the signal difference between the maximum value and the maximum value (or the minimum value and the minimum value) between two consecutive beats in FIG. 5 is smaller than a certain reference. Thus, it is possible to determine a state in which the blood volume difference is within a certain range, that is, the blood volume of both can be regarded as substantially equal. Therefore, it is possible to detect both signals of [the differential sound wave generated by the first light and the second light] and [the sound wave generated by the second light] under the condition that the blood volume fluctuation difference is small. Here, the determination of the extreme value of the pulse wave 21 can be realized by a known technique such as signal processing of a differential value of the waveform.

  Moreover, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, it is desirable to perform the following operation as the third pulse wave sound wave detection procedure. That is, the pulse wave sensor 115 of the component concentration measuring apparatus 10 has a constant time τ2 from the time t5 in FIG. 5 in the first pulse wave sound wave detection procedure and a fixed time from another time point t7 in the second pulse wave sound wave detection procedure. A pulse wave is detected within a certain time τ2 from another time point t9 where the pulse wave 22 of the subject 2 becomes a predetermined value except within τ2, and the first light source 103 falls within a certain time time τ2 from the time point t9. The light of another predetermined one wavelength is electrically modulated and emitted. The sound wave detection unit 111 detects a sound wave within a certain time τ2 from the time point t9, and the phase detection amplification unit 113 measures the sound wave magnitude 62. Here, the third pulse wave sound wave detection procedure includes a first pulse wave sound wave detection procedure, a second pulse wave sound wave detection procedure, a first pulse wave sound wave integration procedure, a second pulse wave sound wave integration procedure, a component concentration calculation procedure, and a first pulse wave sound wave detection procedure. It does not matter before and after the 1 pulse wave confirmation procedure.

  In the control method of the component concentration measuring apparatus 10 according to the present embodiment, the validity of the sound wave intensity acquired in the first and second pulse wave sound wave intensity integrating procedures is obtained by acquiring the sound wave intensity by the third pulse wave sound wave detecting procedure. It is possible to obtain information for verifying.

  Further, when the validity of the sound wave intensity is verified, the component concentration calculation unit 114 calculates the magnitude 62 of the sound wave detected within a predetermined time τ2 from the time t9 in FIG. 5 in the third pulse wave sound wave detection procedure. It is desirable to further have a sound wave intensity integrating procedure for sequentially accumulating and obtaining another single sound wave intensity. Here, in the sound wave intensity integration procedure, the component concentration calculation unit 114 may perform pulse wave integration in real time in the third pulse wave sound wave detection procedure simultaneously with the input of the pulse wave signal from the pulse wave sensor 115, that is, The pulse wave signal may be stored in a memory and performed after the third pulse wave sound wave detection procedure. In addition, the component concentration calculation unit 114 may perform integration of the sound wave size in real time simultaneously with the input of the sound wave signal via the filter 112 and the phase detection amplification unit 113 from the sound wave detection unit 111, You may memorize | store in memory and may perform after a 3rd pulse wave sound wave detection procedure. When the sound wave intensity integrating procedure is performed after the third pulse wave sound wave detecting procedure, the sound wave intensity integrating procedure may be performed at any time after the third pulse wave sound wave detecting procedure.

  In the control method of the component concentration measuring apparatus 10 according to the present embodiment, the sound intensity is acquired by the sound intensity integration procedure, thereby obtaining specific information necessary for verifying the validity of the sound intensity, and the validity of the sound intensity. Can be verified.

  Further, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the integrated value of the sound wave magnitude 61 within the predetermined time τ2 from the time t7 to the time t8 in FIG. Calculate and calculate the absolute value of the difference between a single sound wave intensity and another single sound wave intensity that is an integrated value of the sound wave magnitude 62 within a certain time τ2 from time t9 to time t10, which is the sound wave intensity integration procedure. A sound wave intensity ratio calculating unit that calculates a ratio between the absolute value obtained and the mixed sound wave intensity that is the integrated value of the sound wave magnitude 60 within a predetermined time τ2 from time point t5 to time point t6 as the first pulse wave sound wave intensity integrating procedure. When the ratio to be calculated is greater than 1.05 or less than 0.95, the method further includes a sound intensity confirmation procedure for returning to the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure and repeatedly measuring the component concentration. It is desirable. Here, the sound wave intensity confirmation procedure may be performed at any time after the first pulse wave sound wave integration procedure, the second pulse wave sound wave integration procedure, and the third sound wave intensity integration procedure.

  In the control method of the component concentration measuring apparatus 10 according to the present embodiment, [the differential sound wave signal between the sound wave generated by the first light and the sound wave generated by the second light] and [the sound wave signal generated by the first light] -If the difference between [the sound wave signal generated by the second light] is large, repeat the measurement. Therefore, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the validity of the mixed sound wave intensity and the single sound wave intensity acquired in the first and second pulse wave sound wave intensity integrating procedures is verified, and the component concentration Measurement accuracy can be improved.

  Further, as shown in FIG. 5, the fixed time τ2 is set within one cycle of the pulse wave detected by the pulse wave sensor 115, and the pulse wave sensor 115 detects three consecutive beats of the pulse wave 22 of the subject 2 in FIG. Are detected one beat at a time in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure, and the first light source 103 and the second light source 106 detect the first pulse wave sound wave. In the detection procedure, light of two different wavelengths corresponding to three beats of the pulse wave 22 is emitted after being intensity-modulated electrically with a signal having the same frequency and opposite phase, and the second light source 106 emits the second pulse wave sound wave. In the detection procedure, light of a predetermined wavelength corresponding to three beats of the pulse wave is electrically intensity-modulated and emitted, and the first light source 103 outputs three beats of the pulse wave in the third pulse wave sound wave detection procedure. The other predetermined one wavelength of light corresponding to the minute is electrically modulated and emitted, and the sound wave detection unit 111 First pulse wave acoustic wave detection procedure, it is desirable to detect each of the sound waves in response to 3 beats of the pulse wave at the second pulse wave detection procedure, and the third pulse wave detection procedure. Note that FIG. 5 shows the magnitudes 60, 61, and 62 of sound waves when the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure are performed. As described above, the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure may be performed before or after the procedure.

  In the control method of the component concentration measuring apparatus 10 according to the present embodiment, since the difference in sound wave detection time is small, the validity of the mixed sound wave intensity and single sound wave intensity acquired in the first and second pulse wave sound wave intensity integrating procedures is confirmed. The accuracy of the verification result can be improved.

  Further, in the control method of the component concentration measuring apparatus 10 according to the present embodiment, the detection by the pulse wave sensor 115 in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure. The ratio of the maximum value of any two beats among the pulse waves 22 for five consecutive three beats is calculated, and when the calculated ratio is greater than 1.1 or less than 0.9, the first pulse wave sound wave It is desirable to further include a second pulse wave confirmation procedure for returning to the detection procedure and the second pulse wave sound wave detection procedure and repeatedly measuring the component concentration. Here, the second pulse wave confirmation procedure may be performed at any time after the first pulse wave acoustic wave detection procedure, the second pulse wave acoustic wave detection procedure, and the third pulse wave acoustic wave detection procedure.

  Although the fluctuation of the continuous pulse wave is considered to be small at rest, the pulsation may fluctuate rapidly due to body movements and external factors. The control method of the component concentration measuring apparatus 10 according to the present embodiment is a signal with a maximum value-maximum value (or a minimum value-minimum value) between any two beats among the three consecutive beats of the pulse wave 22 of FIG. Since the difference is smaller than a certain standard, it is possible to determine the blood volume difference within a certain range, that is, a state in which both blood volumes can be regarded as substantially equal. Therefore, any two signals of [differential sound wave generated by the first light and second light], [sound wave generated by the second light] or [sound wave generated by the first light] It can be detected under conditions where the variation difference is small. Here, the determination of the extreme value of the pulse wave can be realized by a known technique such as signal processing of the differential value of the waveform. Further, “calculating the ratio of the maximum value of any two beats” does not necessarily mean that all three combinations of any two beats out of the three beats of the pulse wave are included. In the control method of 10, when the ratio of extreme values is calculated and judged for all three combinations of any two beats out of the pulse waves for three beats, the “condition for small blood volume fluctuation difference” is assured As a result, the component concentration calculation accuracy can be improved.

  3 detects a pulse wave from the sound wave generated in the subject 2 of the light emitted from the first light source 103 and / or the second light source 106, and detects the first light source 103 or / It is desirable to detect a pulse wave from the reflected light of the subject 2 of the light emitted from the second light source 106 or to detect the pulse wave by an electrocardiograph (not shown) or a plethysmograph (not shown). . As described above, the detection of the pulse wave from the reflected light, the detection of the pulse wave by the electrocardiograph, and the detection of the pulse wave by the plethysmograph can be realized by well-known techniques. It is. The detection of the pulse wave from the sound wave is as described above. In addition, the effects described above by detecting a pulse wave from a sound wave, detecting a pulse wave from reflected light, detecting a pulse wave by an electrocardiograph, and detecting a pulse wave by a plethysmograph are as follows. Naturally, it is provided in the control method of the component concentration measuring apparatus 10 according to the embodiment.

  The component concentration measuring apparatus and the component concentration measuring apparatus control method of the present invention can be used for daily health care and cosmetic checks. Moreover, not only a human living body but also an animal living body can be used for health management.

It is the figure which showed the light absorbency characteristic of the water and glucose aqueous solution in normal temperature. It is the figure which showed an example of the graph of the fluctuation | variation by the pulsation of the magnitude | size of a sound wave. It is a schematic block diagram of the component concentration measuring apparatus which concerns on 1 embodiment. It is the schematic which showed one example of the magnitude | size of the sound wave generated synchronizing with a pulse wave and a pulse wave. It is the schematic which showed one example of the magnitude | size of the sound wave generated synchronizing with a pulse wave and a pulse wave. It is a figure which shows the structural example of the conventional blood component density | concentration measuring apparatus by a photoacoustic method. It is a figure which shows the structural example of the conventional blood component density | concentration measuring apparatus by a photoacoustic method.

Explanation of symbols

2: Subject 10: Component concentration measuring device 20: Pulse wave 21: Pulse wave 22: Pulse wave 30: Sound wave size 31: Sound wave size 32: Sound wave size 40: Sound wave of arterial blood 41: Venous blood Sound wave 42: Tissue sound wave 50: Sound wave magnitude 51: Sound wave magnitude 60: Sound wave magnitude 61: Sound wave magnitude 62: Sound wave magnitude 101: Oscillator 102: Drive circuit 103: First light source 104 : 180 ° phase shift circuit 105: drive circuit 106: second light source 107: multiplexing unit 110: acoustic matching substance 111: sound wave detection unit 112: filter 113: phase detection amplification unit 114: component concentration calculation unit 115: pulse wave Sensor 120: modulated light 601: first light source 604: drive circuit 605: second light source 608: drive circuit 609: multiplexing unit 610: subject 613: ultrasonic detector 616: pulse light source 617: chopper plate 618 Motor 619: acoustic sensor 620: waveform observer 621: Frequency analyzer

Claims (30)

The pulse wave detecting means for detecting the pulse wave of the subject detects the pulse wave within the predetermined time within a certain time from the time when the pulse wave of the subject becomes a predetermined value, and outputs light of two different wavelengths. A sound wave detection means for detecting a sound wave generated by the mixed light emitting means that emits light having two wavelengths within the predetermined time, and that emits light having the same frequency and is electrically modulated with an opposite phase signal at the same frequency. A first pulse wave sound wave detection procedure for detecting sound waves within the predetermined time;
The pulse wave detecting means is within the predetermined time period from another time point at which the pulse wave of the subject has a predetermined value except for the predetermined time period from the time point of the first pulse wave sound wave detection procedure. A first single light emitting means that detects a pulse wave in time and emits a predetermined one wavelength of the two different wavelengths of light with an intensity modulated, and emits the light of one wavelength within the predetermined time. And a second pulse wave sound wave detection procedure in which the sound wave detection means detects a sound wave within the predetermined time period;
A method for controlling a component concentration measuring apparatus, comprising: The pulse wave integrating means for integrating the pulse waves detected by the pulse wave detecting means to obtain a pulse wave integrated value sequentially integrates the pulse waves detected within the predetermined time in the first pulse wave sound wave detection procedure. A sound wave intensity integrating unit that acquires the pulse wave integrated value and acquires the sound wave intensity by integrating the magnitude of the sound wave detected by the sound wave detecting unit is detected within the predetermined time in the first pulse wave sound wave detecting procedure. A first pulse wave sound wave intensity integrating procedure for sequentially accumulating sound waves to obtain a mixed sound wave intensity;
The pulse wave integrating means sequentially integrates pulse waves detected within the predetermined time in the second pulse wave sound wave detection procedure to obtain other pulse wave integrated values, and the sound wave intensity integrating means is the second pulse wave integrating means. A second pulse wave sound intensity integration procedure for sequentially integrating the sound waves detected within the predetermined time in the pulse wave sound wave detection procedure to obtain a single sound wave intensity;
The component concentration measuring device control method according to claim 1, further comprising:   A component concentration calculation means for calculating a component concentration to be measured includes a pulse wave integrated value acquired in the first pulse wave sound wave intensity integrating procedure and the second pulse wave sound wave intensity integrating procedure, another pulse wave integrated value, The component concentration measuring device control method according to claim 2, further comprising a component concentration calculating procedure for calculating a component concentration from the mixed sound wave intensity and the single sound wave intensity.   In the component concentration calculation procedure, the component concentration calculation means includes a mixed sound wave intensity standard value obtained by dividing the mixed sound wave intensity by the pulse wave integrated value, and a single sound wave intensity obtained by dividing the single sound wave intensity by the other pulse wave integrated value. 4. The component concentration measuring device control method according to claim 3, wherein the component concentration is calculated from the ratio of the single sound wave intensity standard values. The fixed time is within one cycle of the pulse wave detected by the pulse wave detection means,
The pulse wave detection means detects two consecutive beats of the pulse wave of the subject one beat at a time in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure,
The mixed light emitting means emits light of two different wavelengths corresponding to the two beats in the first pulse wave sound wave detection procedure by electrically modulating the intensity with signals of the same frequency and opposite phase,
The first single light emitting means electrically emits light having a predetermined wavelength corresponding to the two beats in the second pulse wave sound wave detection procedure, and emits light with a predetermined intensity.
The sound wave detection means detects each sound wave corresponding to the two beats in the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection procedure. The component concentration measuring device control method according to claim 1.   First extreme value ratio calculating means for calculating a ratio of maximum values of pulse waves for two consecutive beats detected by the pulse wave detecting means includes the first pulse wave sound wave detection procedure and the second pulse wave sound wave detection. The ratio of the maximum value of the pulse waves for two consecutive beats detected in the procedure is calculated, and when the calculated ratio is larger than 1.1 or smaller than 0.9, the pulse wave detecting means and the mixture The first pulse in which the light emission means returns to the first pulse wave sound wave detection procedure and the pulse wave detection means and the first single light emission means return to the second pulse wave sound wave detection procedure to repeatedly measure the component concentration. 6. The component concentration measuring device control method according to claim 5, further comprising a wave confirmation procedure.   Except for the predetermined time from the time point of the first pulse wave sound wave detection procedure and the predetermined time from the other time point of the second pulse wave sound wave detection procedure, a predetermined value of the pulse wave of the subject The pulse wave detecting means detects the pulse wave within the predetermined time within the predetermined time from another time point, and the other predetermined one wavelength of the two different wavelengths of light is electrically intensified. A third pulse wave sound wave detecting procedure in which the second single light emitting means that emits light after being modulated emits light of one wavelength within the predetermined time period, and the sound wave detecting means detects the sound wave within the predetermined time period; The component concentration measuring device control method according to any one of claims 1 to 6, further comprising:   The sound wave intensity integrating means further comprises a sound wave intensity integrating procedure for sequentially integrating the sound waves detected within the predetermined time in the third pulse wave sound wave detecting procedure to obtain another single sound wave intensity. The component concentration measuring device control method according to claim 7.   The absolute value of the difference between the single sound wave intensity acquired in the second pulse wave sound wave intensity integrating procedure and the other single sound wave intensity acquired in the sound wave intensity integrating procedure is calculated, and the calculated absolute value and the When the ratio calculated by the sound intensity ratio calculating means for calculating the ratio with the mixed sound intensity acquired in the first pulse wave intensity integration procedure is greater than 1.05 or less than 0.95, the pulse wave detection And the mixed light emission means return to the first pulse wave sound wave detection procedure, and the pulse wave detection means and the first single light emission means return to the second pulse wave sound wave detection procedure to repeatedly measure the component concentration. The component concentration measuring device control method according to claim 8, further comprising a sound wave intensity confirmation procedure. The fixed time is within one cycle of the pulse wave detected by the pulse wave detection means,
The pulse wave detecting means outputs one continuous beat of the pulse wave of the subject in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure. Detect one by one,
The mixed light emitting means emits light having two different wavelengths corresponding to the three beats in the first pulse wave sound wave detection procedure by electrically modulating the intensity with signals having the same frequency and opposite phase,
The first single light emitting means electrically emits light having a predetermined wavelength corresponding to the three beats in the second pulse wave sound wave detection procedure, and emits the light with a predetermined intensity.
The second single light emitting means electrically emits light of another predetermined wavelength corresponding to the three beats in the third pulse wave sound wave detection procedure, and emits the light.
The sound wave detecting means detects sound waves corresponding to the three beats in the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure. A method for controlling a component concentration measuring apparatus according to any one of claims 7 to 9.   Second extreme value ratio calculating means for calculating the ratio of the maximum value of any two beats among the pulse waves for three consecutive beats detected by the pulse wave detecting means comprises the first pulse wave sound wave detection procedure, The ratio of the maximum value of any two beats of the pulse waves for three consecutive beats detected in the second pulse wave sound wave detection procedure and the third pulse wave sound wave detection procedure is calculated, and the calculated ratio is 1 .. When greater than 1 or less than 0.9, the pulse wave detecting means and the mixed light emitting means return to the first pulse wave sound wave detection procedure and the pulse wave detecting means and the first single light emission 11. The component concentration measuring apparatus control method according to claim 10, further comprising a second pulse wave confirmation procedure in which the means returns to the second pulse wave sound wave detection procedure and repeatedly measures the component concentration.   In the first pulse wave sound wave detection procedure, the second pulse wave sound wave detection procedure, and the third pulse wave sound wave detection procedure, the pulse wave detection means is the mixed light emission means, the first single light emission means, or the A pulse wave is detected from the sound wave generated from the subject by the light emitted from the second single light emitting means, and the mixed light emitting means, the first single light emitting means, or the second single light emitting means The component concentration according to claim 7, wherein a pulse wave is detected from reflected light of the emitted light from the subject, or a pulse wave is detected by an electrocardiograph or a plethysmograph. Measuring device control method.   The wavelength of the two wavelengths is a wavelength of two wavelengths of light that is larger in the difference in absorption exhibited by the component to be measured than the difference in absorption exhibited by water. The component concentration measuring device control method as described.   Among the two wavelengths of light, the wavelength of the predetermined one wavelength is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the wavelength of the other one wavelength of water is that of the one light. The component concentration measuring device control method according to claim 1, wherein the wavelength exhibits absorption equal to that at the wavelength.   15. The wavelength of the two wavelengths is a wavelength of two wavelengths of light that is larger in the difference in absorption exhibited by the component to be measured than the difference in absorption exhibited by the other components. The component concentration measuring device control method as described. Within a certain time from the time when the pulse wave of the subject becomes a predetermined value, and within the certain time from other time points that become the predetermined value of the pulse wave of the subject and within the certain time from the time Pulse wave detection means for detecting the pulse wave of the subject,
Mixed light emitting means for emitting light of two different wavelengths electrically modulated with opposite phase signals at the same frequency within the predetermined time from the time point; and
First single light emitting means for electrically intensity-modulating and emitting light of a predetermined one of the two different wavelengths of light within the predetermined time from the other time point;
A sound wave generated in the subject by light emitted from the mixed light emitting means within the fixed time is detected within the fixed time from the time point, and within the fixed time from the first single light emitting means. A sound wave detecting means for detecting a sound wave generated in the subject by the light emitted to the subject within the predetermined time from the other time point;
A component concentration measuring apparatus comprising: The pulse waves detected by the pulse wave detection means within the fixed time from the time point are sequentially integrated to obtain a pulse wave integrated value, and the pulse wave detection means within the fixed time from the other time point Pulse wave integrating means for sequentially integrating the pulse waves detected by the pulse wave to obtain other pulse wave integrated values;
The magnitude of the sound wave generated by the two-wavelength light from the mixed light emitting means within the predetermined time from the time point and detected by the sound wave detecting means is sequentially integrated to obtain the mixed sound wave intensity, and the other A sound wave that is generated by light of one wavelength from the first single light emitting means within a certain time from the time point and is acquired by sequentially integrating the magnitudes of sound waves detected by the sound wave detecting means. Intensity integrating means;
The component concentration measuring apparatus according to claim 16, further comprising:   The pulse wave integrated value obtained by the pulse wave integrating means within the fixed time from the time point, the other pulse wave integrated value acquired by the pulse wave integrating means within the fixed time from the other time point, the sound wave Components to be measured from the intensity of the mixed sound wave within a certain time from the time point acquired by the intensity integrating means and the single sound wave intensity within the certain time period from the other time point acquired by the sound wave intensity integrating means The component concentration measuring device according to claim 17, further comprising a component concentration calculating means for calculating a concentration.   The component concentration calculation means includes a mixed sound wave intensity standard value obtained by dividing the mixed sound wave intensity by the pulse wave integrated value, and a single sound wave intensity standard value obtained by dividing the single sound wave intensity by the other pulse wave integrated value. The component concentration measuring apparatus according to claim 18, wherein the component concentration is calculated from the ratio. The fixed time is within one cycle of the pulse wave detected by the pulse wave detection means,
The pulse wave detecting means detects two consecutive beats in the pulse wave of the subject, one beat at a time from the time point and the other time point,
The mixed light emitting means emits light of two different wavelengths corresponding to the two beats within the predetermined time from the time point by electrically modulating the intensity with signals of the same frequency and opposite phase,
The first single light emitting means emits light having a predetermined wavelength that is electrically intensity-modulated within the predetermined time from the other time corresponding to the two beats,
The component concentration measuring apparatus according to claim 16, wherein the sound wave detecting unit detects each sound wave corresponding to the two beats. A first extreme value ratio calculating means for calculating a ratio of maximum values of the pulse waves for two consecutive beats detected by the pulse wave detecting means;
When the ratio calculated by the first extreme value ratio calculating means is larger than 1.1 or smaller than 0.9, the pulse wave detecting means, the mixed light emitting means and the first single light emitting means are: 21. The component concentration measuring apparatus according to claim 20, wherein the component concentration is repeatedly measured. The pulse wave of the subject becomes a predetermined value, and the light of the two different wavelengths is transmitted within the predetermined time from the time point and within the predetermined time period from other time points excluding the predetermined time period from the other time point. A second single light emitting means for electrically modulating the intensity of the other predetermined one of the wavelengths and emitting it;
The pulse wave detecting means includes
Detecting a pulse wave within the certain time from the other time except the certain time from the time and the certain time from the other time;
The sound wave detecting means is configured to output 1 from the second single light emitting means within the certain time from the time and within the certain time from the other time excluding the certain time from the other time. The component concentration measuring device according to any one of claims 16 to 21, wherein a sound wave due to light having a wavelength is detected. The sound wave intensity integrating means is
Generated by the light of one wavelength from the second single light emitting means within the certain time from the other time except for the certain time from the time and within the certain time from the other time. 23. The component concentration measuring apparatus according to claim 22, wherein the intensity of the sound wave detected by the sound wave detecting means is sequentially integrated to obtain another single sound wave intensity. The absolute value of the difference between the single sound wave intensity acquired by the sound wave intensity integrating means and the other single sound wave intensity is calculated, and the mixed sound wave acquired by the calculated absolute value and the sound wave intensity integrating means A sound wave intensity ratio calculating means for calculating a ratio with the intensity;
When the ratio calculated by the sound wave intensity ratio calculating means is larger than 1.05 or smaller than 0.95, the pulse wave detecting means, the mixed light emitting means, and the first single light emitting means have component concentrations. The component concentration measuring device according to claim 23, wherein the component concentration is repeatedly measured. The fixed time is within one cycle of the pulse wave detected by the pulse wave detection means,
The pulse wave detection means includes three consecutive beats of the pulse wave of the subject within the certain time from the time point, within the certain time from the other time point, and from the time point and the other time point. Detecting one beat at a time from the other time except for the fixed time,
The mixed light emitting means emits light of two different wavelengths within the predetermined time from the time point corresponding to the three beats by electrically modulating the intensity with signals having the same frequency and opposite phase,
The first single light emitting means emits light having a predetermined wavelength that is electrically intensity-modulated within the predetermined time from the other time point corresponding to the three beats,
The second single light emitting means corresponds to the three beats and has another predetermined one wavelength within a certain time from the other time except for the certain time from the time and the other time. The light is intensity-modulated and emitted,
25. The component concentration measuring apparatus according to claim 22, wherein the sound wave detecting means detects each sound wave corresponding to the three beats. A second extreme value ratio calculating means for calculating a ratio of the maximum value of any two beats of the pulse waves for three consecutive beats detected by the pulse wave detecting means;
When the ratio calculated by the second extreme value ratio calculating means is larger than 1.1 or smaller than 0.9, the pulse wave detecting means, the mixed light emitting means and the first single light emitting means are 26. The component concentration measuring apparatus according to claim 25, wherein the component concentration is repeatedly measured.   The pulse wave detecting means detects a pulse wave from a sound wave generated from the subject by light emitted from the mixed light emitting means, the first single light emitting means or the second single light emitting means, and A pulse wave is detected from the reflected light from the subject of the light emitted from the mixed light emitting means, the first single light emitting means, or the second single light emitting means, or by an electrocardiograph or a plethysmograph 27. The component concentration measuring apparatus according to claim 22, wherein a pulse wave is detected.   28. The wavelength of the two wavelengths is a wavelength of two wavelengths of light having a difference in absorption exhibited by a component to be measured larger than a difference in absorption exhibited by water. The component concentration measuring apparatus as described.   Among the two wavelengths of light, the wavelength of the predetermined one wavelength is set to a wavelength at which the component to be measured exhibits characteristic absorption, and the wavelength of the other one wavelength of water is that of the one light. 28. The component concentration measuring device according to claim 16, wherein the wavelength of the component exhibits absorption equal to that at the wavelength. 30. The wavelength of the two wavelengths is a wavelength of two wavelengths of light having a difference in absorption exhibited by a component to be measured larger than a difference in absorption exhibited by other components. The component concentration measuring apparatus as described.

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