JP3212679B2 - Medical infusion bag - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion bag used for filling and sealing a medical infusion, and more particularly to a resin bag having excellent heat stability, liquid resistance and heat sealability. The present invention relates to a medical infusion bag.

[0002]

2. Description of the Related Art
As medical infusion bags, those made of relatively flexible soft vinyl chloride resin or ethylene / vinyl acetate copolymer resin are frequently used. Since these infusion bags are closed systems that do not require a ventilation needle during infusion, they have the advantage of not being contaminated by outside air.However, since infusion bags made of soft vinyl chloride resin contain additives such as plasticizers and stabilizers, It is necessary to prevent the elution, and the infusion bag of the ethylene / vinyl acetate copolymer resin has poor heat resistance, and thus has a problem that it needs to be crosslinked.

On the other hand, attempts have been made to solve the above problems by using a polyolefin resin such as a linear low-density polyethylene or polypropylene in a single layer or by laminating them. JP-A-61-1
No. 35664). However, when these polyolefin resins, especially polypropylene, are used without adding additives such as antioxidants and heat stabilizers for effective use in the medical field, thermal degradation occurs and the fluidity is reduced. There was a problem of doing. Further, these polyolefin-based resins were not sufficiently satisfactory in terms of heat sealing properties such as heat sealing strength and heat sealing temperature.

The present invention has been made in view of the above circumstances, and is based on a resin having high heat stability without adding a stabilizer and having excellent heat sealability, melt fluidity, liquid resistance, and elasticity. It is an object of the present invention to provide a medical infusion bag.

[0005]

Means for Solving the Problems As a result of intensive studies, the present inventors have formed a medical infusion bag using a cyclic olefin copolymer having a specific structure having a specific glass transition temperature (Tg). In this case, the inventors have found that the above requirements can be satisfied, and have accomplished the present invention.

That is, the present invention comprises a repeating unit derived from an α-olefin represented by the following general formula [X] and a repeating unit derived from a cyclic olefin represented by the following general formula [Y]. , Glass transition temperature (Tg) 70 ° C
Provided is a medical infusion bag, wherein at least an inner layer is formed from the following cyclic olefin-based copolymer.

Embedded image (In the formula [X], Ra represents ^a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms.)

Embedded image (In the formula [Y], R ^{b to} R ^m each represent a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms or a substituent containing a halogen atom, an oxygen atom or a nitrogen atom, and n represents an integer of 0 or more. .R ^j or ^{R k} and ^{R l} or ^{R m} and may form a ring with each other. ^Further, R b to R ^m are each may be the same or different from each other.)

Hereinafter, the present invention will be described in more detail.
The medical infusion bag of the present invention has at least an inner layer formed of a cyclic olefin copolymer having an α-olefin unit and a cyclic olefin unit. Here, as the α-olefin, the following general formula [X]

Embedded image (In the formula [X], Ra represents ^a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms).

In the repeating unit represented by the general formula [X], ^Ra represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms. Here, as the hydrocarbon group having 1 to 20 carbon atoms, specifically, for example, methyl group, ethyl group, isopropyl group, n-propyl group, isobutyl group, n-butyl group, n-hexyl group, n-octyl And n-octadecyl group. In addition, the general formula [X]
Specific examples of the α-olefin that gives a repeating unit represented by the following are, for example, ethylene, propylene, 1-butene, 3-methyl-1-butene, 4-methyl-1-pentene, 1-hexene, 1-octene, Examples thereof include 1-decene and 1-eicosene.

The cyclic olefin is represented by the following general formula [Y]:

Embedded image (In the formula [Y], R ^{b to} R ^m each represent a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms or a substituent containing a halogen atom, an oxygen atom or a nitrogen atom, and n represents an integer of 0 or more. R ^j or R ^k and R ¹ or R ^m may form a ring with each other, and R ^{b to} R ^m may be the same or different from each other.) Things.

In the repeating unit represented by the general formula [Y], R ^{b to} R ^m each represent a hydrogen atom or a carbon atom
To 20 hydrocarbon groups or substituents containing a halogen atom, an oxygen atom or a nitrogen atom. Here, as the hydrocarbon group having 1 to 20 carbon atoms, specifically, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group,
Alkyl groups having 1 to 20 carbon atoms such as -butyl group, isobutyl group, t-butyl group, hexyl group, etc .; aryl groups having 6 to 20 carbon atoms such as phenyl group, tolyl group, benzyl group, alkylaryl group or arylalkyl. , A methylidene group, an ethylidene group, a propylidene group, etc.
Carbon number 2 such as alkylidene group, vinyl group, allyl group of 0
And -20 alkenyl groups. However,
R ^b , R ^c , R ^f and R ^g exclude an alkylidene group. Note that R
^{When any of d} , R ^e , and R ^{h to} R ^m is an alkylidene group,
The carbon atom to which it is attached has no other substituents.

Specific examples of the substituent containing a halogen atom include halogen substituents such as fluorine, chlorine, bromine and iodine, and halogen substituents having 1 to 20 carbon atoms such as chloromethyl, bromomethyl and chloroethyl. Examples include an alkyl group. Specific examples of the substituent containing an oxygen atom include, for example, an alkoxy group having 1 to 20 carbon atoms such as a methoxy group, an ethoxy group, a propoxy group, and a phenoxy group, and a carbon atom having 1 to 20 carbon atoms such as a methoxycarbonyl group and an ethoxycarbonyl group. And the like. Specifically as a substituent containing a nitrogen atom,
Examples thereof include an alkylamino group having 1 to 20 carbon atoms such as a dimethylamino group and a diethylamino group, and a cyano group.

Specific examples of the cyclic olefin giving the repeating unit represented by the general formula [Y] include, for example, norbornene, 5-methylnorbornene, 5-ethylnorbornene, 5-propylnorbornene, 5,6-dimethylnorbornene, -Methylnorbornene, 7-methylnorbornene, 5,5,6-trimethylnorbornene, 5-
Phenylnorbornene, 5-benzylnorbornene, 5
-Ethylidene norbornene, 5-vinyl norbornene,
1,4,5,8-dimethano-1,2,3,4,4a,
5,8,8a-octahydronaphthalene, 2-methyl-
1,4,5,8-dimethano-1,2,3,4,4a,
5,8,8a-octahydronaphthalene, 2-ethyl-
1,4,5,8-dimethano-1,2,3,4,4a,
5,8,8a-octahydronaphthalene, 2,3-dimethyl-1,4,5,8-dimethano-1,2,3,4,4
a, 5,8,8a-octahydronaphthalene, 2-hexyl-1,4,5,8-dimethano-1,2,3,4,4
a, 5,8,8a-octahydronaphthalene, 2-ethylidene-1,4,5,8-dimethano-1,2,3,4
4a, 5,8,8a-octahydronaphthalene, 2-fluoro-1,4,5,8-dimethano-1,2,3,4
4a, 5,8,8a-octahydronaphthalene, 1,5
-Dimethyl-1,4,5,8-dimetano-1,2,3
4,4a, 5,8,8a-octahydronaphthalene, 2
-Cyclohexyl-1,4,5,8-dimetano-1,
2,3,4,4a, 5,8,8a-octahydronaphthalene, 2,3-dichloro-1,4,5,8-dimethano-
1,2,3,4,4a, 5,8,8a-octahydronaphthalene, 2-isobutyl-1,4,5,8-dimethano-1,2,3,4,4a, 5,8,8a- Octahydronaphthalene, 1,2-dihydrodicyclopentadiene,
5-chloronorbornene, 5,5-dichloronorbornene, 5-fluoronorbornene, 5,5,6-trifluoro-6-trifluoromethylnorbornene, 5-chloromethylnorbornene, 5-methoxynorbornene,
5,6-dicarboxyl norbornene anhydrate, 5-dimethylamino norbornene, 5-cyano norbornene and the like can be mentioned. Among these, norbornene or a derivative thereof is particularly preferred.

The cyclic olefin copolymer used in the present invention is basically obtained by copolymerizing an α-olefin and a cyclic olefin as described above. In addition to these two essential components,
If necessary, another copolymerizable unsaturated monomer component may be used. As such an unsaturated monomer which may be optionally copolymerized, specifically, among the above-mentioned α-olefin components, those not previously used, among the above-mentioned cyclic olefin components, Examples thereof include those not used, cyclic dienes such as dicyclopentadiene and norbornadiene, chain dienes such as butadiene, isoprene, and 1,5-hexadiene, and monocyclic olefins such as cyclopentene and cycloheptene.

The cyclic olefin copolymer used in the present invention has a content of [alpha] -olefin unit [x] and a content of cyclic olefin unit [y] of [x] of 80 to 99.9 mol%. [Y] is 20 to 0.1 mol%, particularly [x] is 82 to 99.5 mol%, and [y] is 18 to 0.5 mol%, especially [x] is 85 to 98 mol%. [Y] is 1
Preferably it is 5 to 2 mol%. If the content [x] of the α-olefin unit is less than 80 mol%, the glass transition temperature (Tg) and the tensile modulus of the copolymer increase, and the elasticity recovery, impact resistance, and elasticity of the infusion bag are increased. May be insufficient. On the other hand, when the content of the cyclic olefin unit [y] is less than 0.1 mol%, the crystallinity of the copolymer increases, and the effect of introducing the cyclic olefin component such as transparency and elastic recovery is insufficient. May be.

The cyclic olefin copolymer used in the present invention is a substantially linear copolymer in which α-olefin units and cyclic olefin units are linearly arranged, and does not have a gel-like crosslinked structure. Preferably, it is The absence of a gel-like crosslinked structure can be confirmed by the fact that the copolymer is completely dissolved in decalin at 135 ° C.

The cyclic olefin copolymer used in the present invention preferably has an intrinsic viscosity [η] of 0.01 to 20 dl / g measured in decalin at 135 ° C. If the intrinsic viscosity [η] is less than 0.01 dl / g, the strength may be significantly reduced, and if it exceeds 20 dl / g, the moldability may be significantly deteriorated. More preferred intrinsic viscosity [η] is 0.05 to 10 dl / g.

Although the molecular weight of the cyclic olefin copolymer used in the present invention is not particularly limited, the weight average molecular weight Mw measured by gel permeation chromatography (GPC) (in terms of polyethylene) is 1,0.
00 to 2,000,000, especially 5,000 to 1,000
000, the number average molecular weight Mn is 500 to 1,000,
000, especially 2,000 to 800,000, and a molecular weight distribution (Mw / Mn) of 1.3 to 4, particularly preferably 1.4 to 3. When the molecular weight distribution (Mw / Mn) is more than 4, the content of the low molecular weight compound increases, which may cause the infusion bag to become sticky.

The cyclic olefin copolymer used in the present invention must have a glass transition temperature (Tg) of 70 ° C. or less. When such a copolymer is used, an infusion bag excellent in thermal stability and liquid resistance can be obtained, in particular, with no or little addition of a stabilizer and no risk of elution. A more preferred glass transition temperature (Tg) is -50 to 5
0 ° C., especially −30 to 30 ° C. In this case, the cyclic olefin-based copolymer used in the present invention can control the glass transition temperature (Tg) arbitrarily by changing the type and composition of the monomer, and is used for the intended application and use. The glass transition temperature (Tg) can be arbitrarily changed according to the temperature or the like.

The cyclic olefin copolymer used in the present invention has a crystallinity of 0 to 4 as measured by an X-ray diffraction method.
It is preferably 0%. When the crystallinity exceeds 40%, elastic recovery and transparency may be reduced. A more preferred crystallinity is 0 to 30%, particularly 0 to 25%.

The cyclic olefin copolymer used in the present invention desirably has a tensile modulus of less than 3,000 kg / cm ² . When the tensile modulus is 3,000 kg / cm ² or more, the impact resistance of the infusion bag may be insufficient. More preferred tensile modulus is 50 to 2,000K
g / cm ² .

The cyclic olefin copolymer used in the present invention preferably has an elastic recovery of 20% or more. If the elastic recovery rate is less than 20%, the shape of the infusion bag may be lost due to external force, or the thickness may be partially reduced and the strength may be reduced. A more preferable elastic recovery rate is 30% or more, particularly 40% or more. The elastic recovery was measured using an autograph at a tensile speed of 62 mm / min, a width of 6 mm,
A test piece with a distance of 50 mm (L ₀ ) between the clamps is stretched by 150% and pulled, and after maintaining the state for 5 minutes, suddenly shrunk without rebound, and the sheet length between the clamps (L ₁ ) after 1 minute Is measured, and is a value obtained by the following equation. Elastic recovery rate (%) = [1 − {(L ₁ −L ₀ ) / L ₀ }] ×
100

The cyclic olefin copolymer used in the present invention preferably has a broad melting peak of less than 90 ° C. by DSC (measurement of temperature rise). DSC (heating measurement)
A copolymer having a sharp melting peak at 90 ° C. or higher due to a wide distribution of the copolymer of a cyclic olefin and an α-olefin may cause insufficient elastic recovery of an infusion bag. In addition, it is more preferable that the broad melting peak by DSC (temperature rise measurement) is in the range of 10 to 85 ° C. In DSC (measurement of temperature rise), the melting point (melting peak) of the olefin-based copolymer is not seen sharply, and especially in the case of those having a low crystallinity, almost no peak is observed at the level of ordinary polyethylene measurement conditions. Does not appear. In addition, the cyclic olefin copolymer used in the present invention has a crystallization peak by DSC (temperature drop measurement),
It is preferable to have one or more relatively small sub-peaks on the high temperature side of the main peak. Due to the characteristics of the thermal properties described above, the physical properties of the infusion bag can be obtained, and the infusion bag can be molded stably, for example, the molding temperature range is widened.

The cyclic olefin copolymer used in the present invention may be a copolymer consisting of only those having physical properties in the above-mentioned range, and some copolymers having physical properties out of the above-mentioned range are included. May be used. In the latter case, it is sufficient that the entire physical property value is included in the above range.

The method for producing the cyclic olefin copolymer used in the present invention is not limited, but a catalyst containing the following compounds (A) and (B) as main components or the following compound (A):
By efficiently copolymerizing an α-olefin and a cyclic olefin using a catalyst containing (B) and (C) as main components, it is possible to efficiently produce the copolymer. (A) a transition metal compound (B) a compound which reacts with a transition metal compound to form an ionic complex (C) an organoaluminum compound

In this case, the transition metal compound (A) may be selected from the groups IVB, VB, VIB, VIIB, VIB of the periodic table.
Transition metal compounds containing transition metals belonging to Group II can be used. As the transition metal, specifically, titanium, zirconium, hafnium, chromium, manganese, nickel, palladium, platinum and the like are preferable, and among them, zirconium, hafnium, titanium, nickel and palladium are preferable.

Examples of the transition metal compound (A) include various compounds. In particular, compounds containing a transition metal of Group IVB and Group VIII, particularly a transition metal selected from Group IVB of the periodic table, ie, Compounds containing titanium (Ti), zirconium (Zr) or hafnium (Hf) can be suitably used. Particularly, compounds represented by the following general formula (I),
A cyclopentadienyl compound represented by (II) or (III) or a derivative thereof, or a compound represented by the following general formula (IV) or a derivative thereof is preferable. ^{_{CpM 1 R 1 a R 2 b}} R 3 c ... (I) Cp 2 M 1 R 1 a R 2 b ... (II) (Cp-A e -Cp) M 1 R 1 a R 2 b ... (III) M ¹ R ¹ _a R ² _b R ³ _c R ⁴ _d ... (IV)

[In the formulas (I) to (IV), M ¹ is Ti, Zr
Or Hf atom, Cp is a cyclopentadienyl group,
It represents a cyclic unsaturated hydrocarbon group or a chain unsaturated hydrocarbon group such as a substituted cyclopentadienyl group, an indenyl group, a substituted indenyl group, a tetrahydroindenyl group, a substituted tetrahydroindenyl group, a fluorenyl group or a substituted fluorenyl group. R ¹ , R ² , R ³ and R ⁴ are each σ
Ligands such as binding ligands, chelating ligands, and Lewis bases are shown. Specific examples of the σ binding ligand include a hydrogen atom, an oxygen atom, a halogen atom, and a carbon atom having 1 to 1 carbon atoms. 20 alkyl groups, C1-C20 alkoxy groups, C6-C6
Examples of the aryl group include an aryl group, an alkylaryl group or an arylalkyl group having 20 carbon atoms, an acyloxy group having 1 to 20 carbon atoms, an allyl group, a substituted allyl group, a substituent containing a silicon atom, and the like. Examples include an acetylacetonate group and a substituted acetylacetonate group. A represents a covalent crosslink. a, b, c and d
Is an integer of 0 to 4, and e is an integer of 0 to 6. R
Two or more of ¹ , R ² , R ³ and R ⁴ may combine with each other to form a ring. When Cp has a substituent, the substituent is preferably an alkyl group having 1 to 20 carbon atoms. In the formulas (II) and (III), the two Cp's may be the same or different from each other. ]

The substituted cyclopentadienyl group in the above formulas (I) to (III) includes, for example, methylcyclopentadienyl group, ethylcyclopentadienyl group, isopropylcyclopentadienyl group, 1,2-dimethyl Cyclopentadienyl group, tetramethylcyclopentadienyl group, 1,3-dimethylcyclopentadienyl group, 1,
2,3-trimethylcyclopentadienyl group, 1,2,2
4-trimethylcyclopentadienyl group, pentamethylcyclopentadienyl group, trimethylsilylcyclopentadienyl group and the like. In addition, the above (I) to (I
Specific examples of R ^{1 to} R ^{4 in} the formula V) include, for example, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom as a halogen atom; a methyl group, an ethyl group, and an n-propyl group as an alkyl group having 1 to 20 carbon atoms. Group, iso-propyl group,
n-butyl group, octyl group, 2-ethylhexyl group; methoxy group, ethoxy group, propoxy group, butoxy group, phenoxy group as C1-C20 alkoxy group; C6-C20 aryl group, alkylaryl group or A phenyl group, a tolyl group, a xylyl group, or a benzyl group as an arylalkyl group; a heptadecylcarbonyloxy group as an acyloxy group having 1 to 20 carbon atoms; a trimethylsilyl group or a (trimethylsilyl) methyl group as a substituent containing a silicon atom: Lewis base As dimethyl ether,
Ethers such as diethyl ether and tetrahydrofuran, thioethers such as tetrahydrothiophene, esters such as ethylbenzoate, nitriles such as acetonitrile and benzonitrile, trimethylamine, triethylamine, tributylamine, N, N-dimethylaniline, pyridine, 2,2 Amines such as 2'-bipyridine and phenanthroline; phosphines such as triethylphosphine and triphenylphosphine; linear unsaturated hydrocarbons such as ethylene, butadiene, 1-pentene, isoprene, pentadiene, 1-hexene and derivatives thereof;
Examples of the cyclic unsaturated hydrocarbon include benzene, toluene, xylene, cycloheptatriene, cyclooctadiene, cyclooctatriene, cyclooctatetraene, and derivatives thereof. Examples of the crosslink by a covalent bond of A in the above formula (III) include a methylene bridge, a dimethylmethylene bridge, an ethylene bridge,
Examples include a cyclohexylene cross-link, a dimethylsilylene cross-link, a dimethylgermylene cross-link, and a dimethylstannylene cross-link.

Examples of such compounds include the following compounds and compounds obtained by substituting zirconium of these compounds with titanium or hafnium. Compounds of formula (I) (pentamethylcyclopentadienyl) trimethylzirconium, (pentamethylcyclopentadienyl) triphenylzirconium, (pentamethylcyclopentadienyl) tribenzylzirconium, (pentamethylcyclopentadienyl) trichloro Zirconium, (pentamethylcyclopentadienyl) trimethoxyzirconium, (cyclopentadienyl) trimethylzirconium, (cyclopentadienyl) triphenylzirconium, (cyclopentadienyl) tribenzylzirconium, (cyclopentadienyl) trichloro Zirconium, (cyclopentadienyl) trimethoxyzirconium, (cyclopentadienyl) dimethyl (methoxy) zirconium, (methylcyclopentadienyl) trimethyldi Ruconium, (methylcyclopentadienyl) triphenylzirconium, (methylcyclopentadienyl) tribenzylzirconium, (methylcyclopentadienyl) trichlorozirconium, (methylcyclopentadienyl) dimethyl (methoxy) zirconium,
(Dimethylcyclopentadienyl) trichlorozirconium, (trimethylcyclopentadienyl) trichlorozirconium, (trimethylsilylcyclopentadienyl) trimethylzirconium, (tetramethylcyclopentadienyl) trichlorozirconium,

A compound of formula (II) bis (cyclopentadienyl) dimethylzirconium,
Bis (cyclopentadienyl) diphenyl zirconium, bis (cyclopentadienyl) diethyl zirconium, bis (cyclopentadienyl) dibenzylzirconium, bis (cyclopentadienyl) dimethoxyzirconium, bis (cyclopentadienyl) dichlorozirconium , Bis (cyclopentadienyl) dihydridozirconium, bis (cyclopentadienyl) monochloromonohydridozirconium, bis (methylcyclopentadienyl) dimethylzirconium, bis (methylcyclopentadienyl) dichlorozirconium, bis (methylcyclo Pentadienyl) dibenzyl zirconium, bis (pentamethylcyclopentadienyl) dimethyl zirconium, bis (pentamethylcyclopentadienyl) dichlorozirconium, Scan (pentamethylcyclopentadienyl) dibenzyl zirconium, bis (pentamethylcyclopentadienyl) chloromethyl zirconium,
Bis (pentamethylcyclopentadienyl) hydridomethylzirconium, (cyclopentadienyl) (pentamethylcyclopentadienyl) dichlorozirconium,

Compound of the formula (III) : ethylenebis (indenyl) dimethylzirconium, ethylenebis (indenyl) dichlorozirconium, ethylenebis (tetrahydroindenyl) dimethylzirconium, ethylenebis (tetrahydroindenyl) dichlorozirconium, dimethylsilylenebis (cyclo) (Pentadienyl) dimethyl zirconium, dimethylsilylenebis (cyclopentadienyl) dichlorozirconium, isopropylidene (cyclopentadienyl) (9-fluorenyl) dimethylzirconium, isopropylidene (cyclopentadienyl) (9-fluorenyl) dichlorozirconium , [Phenyl (methyl) methylene] (9-fluorenyl) (cyclopentadienyl) dimethylzirconium, diphenylmethylene Tadienyl)
(9-fluorenyl) dimethyl zirconium, ethylene (9-fluorenyl) (cyclopentadienyl) dimethyl zirconium, cyclohexylidene (9-fluorenyl) (cyclopentadienyl) dimethyl zirconium,
Cyclopentylidene (9-fluorenyl) (cyclopentadienyl) dimethylzirconium, cyclobutylidene (9-fluorenyl) (cyclopentadienyl) dimethylzirconium, dimethylsilylene (9-fluorenyl) (cyclopentadienyl) dimethylzirconium,
Dimethylsilylenebis (2,3,5-trimethylcyclopentadienyl) dichlorozirconium, dimethylsilylenebis (2,3,5-trimethylcyclopentadienyl) dimethylzirconium, dimethylsilylenebis (indenyl) dichlorozirconium

Examples of compounds other than the cyclopentadienyl compounds represented by the above general formulas (I), (II) and (III) include the compounds of the above formula (IV). Examples include zirconium compounds, hafnium compounds, and titanium compounds having one or more of an alkyl group, an alkoxy group, and a halogen atom, such as a compound in which zirconium is replaced with hafnium or titanium. Tetramethyl zirconium, tetrabenzyl zirconium, tetramethoxy zirconium, tetraethoxy zirconium, tetrabutoxy zirconium, tetrachloro zirconium, tetrabromo zirconium,
Butoxytrichlorozirconium, dibutoxydichlorozirconium, bis (2,5-di-t-butylphenoxy) dimethylzirconium, bis (2,5-di-t-butylphenoxy) dichlorozirconium, zirconium bis (acetylacetonate),

The transition metal compound containing a VB-VIII transition metal is not particularly limited, and specific examples of the chromium compound include, for example, tetramethylchromium, tetra (t
-Butoxy) chromium, bis (cyclopentadienyl) chromium, hydridetricarbonyl (cyclopentadienyl) chromium, hexacarbonyl (cyclopentadienyl) chromium, bis (benzene) chromium, tricarbonyltris (triphenylphosphonate) Chromium, tris (allyl) chromium, triphenyltris (tetrahydrofuran) chromium, chromium tris (acetylacetonate) and the like can be mentioned.

Specific examples of the manganese compound include, for example, tricarbonyl (cyclopentadienyl) manganese, pentacarbonylmethylmanganese, bis (cyclopentadienyl) manganese, manganese bis (acetylacetonate) and the like.

Specific examples of the nickel compound include, for example, dicarbonylbis (triphenylphosphine) nickel, dibromobis (triphenylphosphine) nickel, dinitrogenbis (bis (tricyclohexylphosphine) nickel), chlorohydridobis (tricyclohexyl) Phosphine) nickel, chloro (phenyl) bis (triphenylphosphine) nickel, dimethylbis (trimethylphosphine) nickel, diethyl (2,
2'-bipyridyl) nickel, bis (allyl) nickel, bis (cyclopentadienyl) nickel, bis (methylcyclopentadienyl) nickel, bis (pentamethylcyclopentadienyl) nickel, allyl (cyclopentadienyl) Nickel, (cyclopentadienyl)
(Cyclooctadiene) nickel tetrafluoroborate, bis (cyclooctadiene) nickel, nickel bisacetylacetonate, allylnickel chloride,
Tetrakis (triphenylphosphine) nickel, nickel _{chloride, (C 6 H 5) Ni} {OC (C 6 H 5) CH = P (C 6 H 5) 2} {P (C 6 H 5) 3}, ( _{C 6 H 5) Ni {OC} (C 6 H 5) C (SO 3 Na) = P (C 6 H 5) 2} {P (C 6 H 5) 3} and the like.

Specific examples of the palladium compound include, for example, dichlorobis (benzonitrile) palladium, carbonyltris (triphenylphosphine) palladium,
Dichlorobis (triethylphosphine) palladium, bis (t-butyl isocyanate) palladium, palladium bis (acetylacetonate), dichloro (tetraphenylcyclobutadiene) palladium, dichloro (1,5
-Cyclooctadiene) palladium, allyl (cyclopentadienyl) palladium, bis (allyl) palladium, allyl (1,5-cyclooctadiene) palladium tetrafluoroborate, (acetylacetonate)
(1,5-cyclooctadiene) palladium tetrafluoroborate, tetrakis (acetonitrile) palladium ditetrafluoroborate and the like can be mentioned.

Next, as the compound (B), any compound can be used as long as it reacts with the transition metal compound (A) to form an ionic complex. A compound comprising a bound anion, particularly a coordination complex compound comprising a cation and an anion having a plurality of groups bound to an element, can be suitably used. As a compound comprising such a cation and an anion in which a plurality of groups are bonded to an element, the following formula (V) or (VI)
The compound shown by can be used suitably. ^{([L 1 -R 7] k} +) p ([M 3 Z 1 Z 2 ... Z n] (nm) -) q ... (V) ([L 2] k +) p ([M 4 Z 1 Z 2 ... ^{Z n] (nm) -)} q ... (VI) ( where, L ² is ^{M 5, R 8 R 9 M} 6, R 10 is ₃ C or R ¹¹ M ⁶⁾

In the formulas (V) and (VI), L ¹ is a Lewis base, M ³ and M ⁴ are groups VB, VIB and V of the periodic table, respectively.
IIB, VIII, IB, IIB, IIIA, IVA and
Element selected from Group VA, preferably, a Group IIIA, elements selected from Group IVA, and group VA, IIIB group of M ⁵ and M ^6, respectively Periodic Table, IVB group, VB group, VIB group, VIIB group, V
Group III, IA Group, IB, Group IIA, element selected from Group IIB and VIIA group, Z ¹ to Z ⁿ are each a hydrogen atom, a dialkylamino group, an alkoxy group having 1 to 20 carbon atoms, 6 to 20 carbon atoms Aryloxy group, alkyl group having 1 to 20 carbon atoms, aryl group having 6 to 20 carbon atoms, alkylaryl group, arylalkyl group, halogen-substituted hydrocarbon group having 1 to 20 carbon atoms, acyloxy having 1 to 20 carbon atoms group, an organometalloid group or a halogen atom, Z ¹ to Z ⁿ may form a ring of two or more thereof with each other. R ⁷
Represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms,
20 aryl group, an alkyl group, or an arylalkyl group, each R ⁸ and R ⁹ are a cyclopentadienyl group, substituted cyclopentadienyl group, an indenyl group or a fluorenyl group, R ¹⁰ is 1 to 20 carbon atoms It represents an alkyl group, an aryl group, an alkylaryl group or an arylalkyl group. R ¹¹ is tetraphenylporphyrin,
It shows a macrocyclic ligand such as phthalocyanine. m is M ³ , M
A valence of ⁴ and an integer of 1 to 7, n is an integer of 2 to 8 and k is an integer of 1 to 7 of an ionic valence of [L ¹ -R ⁷ ] and [L ² ];
p is an integer of 1 or more, and q = (p × k) / (nm). ]

Specific examples of the above Lewis base include ammonia, methylamine, aniline, dimethylamine, diethylamine, N-methylaniline, diphenylamine,
Amines such as trimethylamine, triethylamine, tri-n-butylamine, N, N-dimethylaniline, methyldiphenylamine, pyridine, p-bromo-N, N-dimethylaniline, p-nitro-N, N-dimethylaniline, and triethylphosphine Phosphines such as triphenylphosphine and diphenylphosphine; ethers such as dimethyl ether, diethyl ether, tetrahydrofuran and dioxane; thioethers such as diethylthioether and tetrahydrothiophene; and esters such as ethylbenzoate. Specific examples of M ³ and M ⁴ are B, Al, Si, P, As, Sb and the like, preferably B or P, and specific examples of M ⁵ are Li, Na, A
g, Cu, Br, I, I 3 , etc., specific examples of M ⁶ M
n, Fe, Co, Ni, Zn and the like.

Specific examples of Z ^{1 to} Z ⁿ include, for example, a dimethylamino group and a diethylamino group as a dialkylamino group; a methoxy group, an ethoxy group and an n-butoxy group as an alkoxy group having 1 to 20 carbon atoms; A phenoxy group, a 2,6-dimethylphenoxy group, a naphthyloxy group as an aryloxy group having from 20 to 20; a methyl group, an ethyl group, an n-propyl group as an alkyl group having from 1 to 20 carbon atoms;
iso-propyl group, n-butyl group, n-octyl group,
2-ethylhexyl group; an aryl group having 6 to 20 carbon atoms,
A phenyl group, p-tolyl group, benzyl group, 4-tert-butylphenyl group, 2,6-dimethylphenyl group,
3,5-dimethylphenyl group, 2,4-dimethylphenyl group, 2,3-dimethylphenyl group; p-fluorophenyl group, 3,5-difluorophenyl group as a halogen-substituted hydrocarbon group having 1 to 20 carbon atoms, Pentachlorophenyl group, 3,4,5-trifluorophenyl group, pentafluorophenyl group, 3,5-bis (trifluoromethyl) phenyl group; F, Cl, Br,
I; Examples of the organic metalloid group include a pentamethylantimony group, a trimethylsilyl group, a trimethylgermyl group, a diphenylarsine group, a dicyclohexylantimony group, and a diphenylboron group. Specific examples of R ⁷ and R ¹⁰ include:
The same ones as mentioned above can be mentioned. R ⁸ and R ⁹
Specific examples of the substituted cyclopentadienyl group include those substituted with an alkyl group such as a methylcyclopentadienyl group, a butylcyclopentadienyl group, and a pentamethylcyclopentadienyl group. Here, the alkyl group usually has 1 to 6 carbon atoms, and the number of substituted alkyl groups can be selected as an integer of 1 to 5. (V), (V
Among the compounds of the formula (I), those in which M ³ and M ⁴ are boron are preferred.

Among the compounds of the formulas (V) and (VI), the following compounds can be particularly preferably used. Compound of formula (V): triethylammonium tetraphenylborate, tri (n-butyl) ammonium tetraphenylborate, trimethylammonium tetraphenylborate, tetraethylammonium tetraphenylborate, methyltri (n-butyl) ammonium tetraphenylborate, benzyltributyltetraphenylborate (N-butyl) ammonium, dimethyldiphenylammonium tetraphenylborate, methyltriphenylammonium tetraphenylborate, trimethylanilinium tetraphenylborate, methylpyridinium tetraphenylborate, benzylpyridinium tetraphenylborate, methyltetraphenylborate (2-cyanopyridinium ), Trimethylsulfonium tetraphenylborate, benzyldimethylsulfonium tetraphenylborate ,

Triethylammonium tetrakis (pentafluorophenyl) borate, tri (n-butyl) ammonium tetrakis (pentafluorophenyl) borate, triphenylammonium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluorophenyl) borate
Tetrabutylammonium borate, tetrakis (pentafluorophenyl) borate (tetraethylammonium),
Tetrakis (pentafluorophenyl) borate (methyltri (n-butyl) ammonium), tetrakis (pentafluorophenyl) borate (benzyltri (n-butyl))
Ammonium), methyldiphenylammonium tetrakis (pentafluorophenyl) borate, methyltriphenylammonium tetrakis (pentafluorophenyl) borate, dimethyldiphenylammonium tetrakis (pentafluorophenyl) borate, anilinium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluoro) Phenyl) methylanilinium borate,
Dimethylanilinium tetrakis (pentafluorophenyl) borate, trimethylanilinium tetrakis (pentafluorophenyl) borate, dimethyltetrakis (pentafluorophenyl) borate (m-nitroanilinium), dimethyltetrakis (pentafluorophenyl) borate (p-bromo) Anilinium),

Pyridinium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluorophenyl) borate (p-cyanopyridinium), tetrakis (pentafluorophenyl) borate (N-methylpyridinium), tetrakis (pentafluorophenyl) borate (N
-Benzylpyridinium), tetrakis (pentafluorophenyl) borate (O-cyano-N-methylpyridinium), tetrakis (pentafluorophenyl) borate (p
-Cyano-N-methylpyridinium), tetrakis (pentafluorophenyl) borate (p-cyano-N-benzylpyridinium), trimethylsulfonium tetrakis (pentafluorophenyl) borate, benzyldimethylsulfonium tetrakis (pentafluorophenyl) borate, tetrakis ( Tetraphenylphosphonium pentafluorophenyl) borate, triphenylphosphonium tetrakis (pentafluorophenyl) borate, dimethylanilinium tetrakis [3,5-bis (trifluoromethyl) phenyl] borate, triethylammonium hexafluoroarsenate,

Compound of formula (VI) Ferrocenium tetraphenylborate, silver tetraphenylborate, trityl tetraphenylborate, manganese tetraphenylborate (ferromanganese tetraphenylporphyrin), ferrocenium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluorophenyl) borate (1,1'-
Dimethylferrocenium), decamethylferrocenium tetrakis (pentafluorophenyl) borate, acetylferrocenium tetrakis (pentafluorophenyl) borate, formylferrocenium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluorophenyl) borate Cyanoferrocenium, silver tetrakis (pentafluorophenyl) borate, trityl tetrakis (pentafluorophenyl) borate, lithium tetrakis (pentafluorophenyl) borate, sodium tetrakis (pentafluorophenyl) borate, tetrakis (pentafluorophenyl) borate (tetra Phenylporphyrin manganese), tetrakis (pentafluorophenyl) borate (tetraphenylporphyrin iron chloride), tetrakis (pentafluoro) Phenyl) borate (tetraphenylporphyrin zinc), silver tetrafluoroborate, hexafluoroarsenate, silver hexafluoroantimonate, silver

Compounds other than those of the formulas (V) and (VI), for example, tris (pentafluorophenyl) boron, tris [3,5-bis (trifluoromethyl) phenyl] boron, triphenylboron and the like can also be used. is there.

Examples of the organoaluminum compound as the component (C) include compounds represented by the following general formulas (VII), (VIII) and (IX). R ¹² _r AlQ _3-r (VII) (R ¹² is a hydrocarbon group having 1 to 20 carbon atoms, preferably 1 to ¹² carbon atoms such as an alkyl group, an alkenyl group, an aryl group and an arylalkyl group; Q is a hydrogen atom; Represents an alkoxy group or a halogen atom having 1 to 20 carbon atoms, and r is in the range of 1 ≦ r ≦ 3.) As the compound of the formula (VII), specifically, trimethylaluminum, triethylaluminum, triisopropyl Examples include aluminum, triisobutylaluminum, dimethylaluminum chloride, diethylaluminum chloride, methylaluminum dichloride, ethylaluminum dichloride, dimethylaluminum fluoride, diisobutylaluminum hydride, diethylaluminum hydride, and ethylaluminum sesquichloride.

[0047]

Embedded image (R ¹² is the same as in formula (VII). S indicates the degree of polymerization, and is usually 3 to 50, preferably 7 to 40.)

[0048]

Embedded image (R ¹² is the same as in formula (VII). S represents the degree of polymerization, and the number of repeating units is preferably from 3 to 50, and preferably from 7 to 40.) Aluminoxane. Among the compounds of the formulas (VII) to (IX), preferred are an alkyl group having 3 or more carbon atoms, especially an alkyl group-containing aluminum compound having at least one or more branched alkyl group or an aluminoxane. Particularly preferred is triisobutylaluminum or an aluminoxane having a degree of polymerization of 7 or more. When this triisobutylaluminum, aluminoxane having a polymerization degree of 7 or more, or a mixture thereof, high activity can be obtained. Further, a modified aluminoxane which is insoluble in a usual solvent obtained by modifying an aluminoxane represented by the formulas (VIII) to (IX) with a compound having active hydrogen such as water is also preferably used.

Examples of the method for producing the aluminoxane include a method in which an alkylaluminum is brought into contact with a condensing agent such as water, but the method is not particularly limited, and the reaction may be carried out according to a known method. For example, a method in which an organoaluminum compound is dissolved in an organic solvent and brought into contact with water, a method in which an organoaluminum compound is added at the beginning of polymerization and water is added later, a crystal water contained in a metal salt or the like, A method of reacting water adsorbed on inorganic or organic substances with an organoaluminum compound, a method of reacting a trialkylaluminum with a tetraalkyldialuminoxane, and further reacting water.

The catalyst used in the production of the olefin-based copolymer of the present invention comprises the above-mentioned components (A) and (B) or (A)
(B) and (C) are the main components. In this case, the use conditions of the component (A) and the component (B) are not limited, but the ratio (molar ratio) of the component (A) to the component (B) is 1:
It is preferably from 0.01 to 1: 100, particularly preferably from 1: 0.5 to 1:10, especially preferably from 1: 1 to 1: 5. The working temperature is preferably in the range of -100 to 250 ° C, and the pressure and time can be set arbitrarily.

The component (C) is used in an amount of usually 0 to 2,000 mol, preferably 5 to 5 mol per mol of the component (A).
It is 1,000 mol, particularly preferably 10 to 500 mol. When the component (C) is used, the polymerization activity can be improved. However, when the content is too large, a large amount of the organic aluminum compound remains in the polymer, which is not preferable.

There is no limitation on the mode of use of the catalyst component. For example, the components (A) and (B) may be brought into contact with each other in advance, or the contact product may be separated and washed before use. It may be used in contact. Further, the component (C) may be used in contact with the component (A), the component (B) or a contact product of the component (A) and the component (B) in advance.
The contact may be made in advance, or may be brought into contact in the polymerization system. Further, the catalyst component can be added in advance to the monomer and the polymerization solvent, or can be added to the polymerization system. The catalyst component can be used by supporting it on an inorganic or organic carrier, if necessary.

The usage ratio of the catalyst to the reaction raw material is such that the raw material monomer / the component (A) (molar ratio) or the raw material monomer / the component (B) (molar ratio) is 1 to 10 ⁹ , especially 1
It is preferable to be a 00-10 ^7.

The polymerization methods include bulk polymerization, solution polymerization,
Any method such as suspension polymerization and gas phase polymerization may be used.
Further, a batch method or a continuous method may be used. When a polymerization solvent is used, for example, aromatic hydrocarbons such as benzene, toluene, xylene, and ethylbenzene; alicyclic hydrocarbons such as cyclopentane, cyclohexane, and methylcyclohexane;
Aliphatic hydrocarbons such as pentane, hexane, heptane and octane, and halogenated hydrocarbons such as chloroform and dichloromethane can be used. These solvents may be used alone or in combination of two or more. Further, a monomer such as an α-olefin may be used as the solvent.

Regarding the polymerization conditions, the polymerization temperature is -100 to 2
The temperature is preferably set to 50 ° C., particularly −50 to 200 ° C.
The polymerization time is usually 1 minute to 10 hours, and the reaction pressure is normal pressure to 10 hours.
0 kg / cm ² G, preferably normal pressure to 50 kg / cm ² G
It is. As a method for adjusting the molecular weight of the copolymer, it is possible to select the amount of each catalyst component used and the polymerization temperature, and furthermore, to carry out the polymerization reaction in the presence of hydrogen.

The infusion bag of the present invention comprises at least the innermost layer of a film formed of the above-mentioned cyclic olefin copolymer layer having excellent chemical resistance and thermal stability. In this case, the cyclic olefin-based copolymer layer is an α-olefin / cyclic olefin copolymer composed of an α-olefin and a cyclic olefin or a mixture of the α-olefin and the cyclic diene,
Α-olefin copolymerized with dienes such as cyclic dienes
It can be formed from a cyclic olefin / diene copolymer, a crosslinked product by thermal crosslinking, radiation crosslinking, or the like with the above. When a crosslinked product of the above is used, the heat resistance of the cyclic olefin-based copolymer layer is improved. Examples of the crosslinking agent used for crosslinking the crosslinked product include organic peroxides and diazo compounds which are generally used. Specifically, benzoyl peroxide, dicumyl peroxide, di-tert-butyl peroxide, tert-butyl cumyl peroxide, tert-butyl hydroperoxide, cumene hydroperoxide, azobisisobutyronitrile and the like. . The amount of the crosslinking agent used is 0.01 to the copolymer.
% By weight or more, preferably 0.03 to 1% by weight.

The structure of the film forming the infusion bag of the present invention is not limited, and a single-layer film made of the cyclic olefin copolymer may be used, and the innermost layer made of the cyclic olefin copolymer may be used. May be used. In the latter case, layers other than the innermost layer are preferably formed of a resin having higher heat resistance than the cyclic olefin copolymer, for example, a propylene / ethylene copolymer, whereby an infusion bag having excellent heat resistance is obtained. be able to.

The infusion bag of the present invention can be manufactured by a usual bag-making method, and can be formed into any shape and size according to the purpose of use. As a bag-making method, for example, a method of forming a single-layer or multilayer film having a cyclic olefin-based copolymer layer and forming a bag from this film, a method of forming a bag by blow molding, and the like can be employed. When a bag is formed from a film, the films may be stacked, the periphery may be heat-sealed in a predetermined shape, the bag may be formed, and a plug member obtained by injection molding of polyethylene or polypropylene may be attached by heat sealing.

[0059]

EXAMPLES Next, the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the following examples. First, prior to the production of a medical infusion bag, a cyclic olefin copolymer of the following reference example was produced.

Reference Example 1 (Copolymerization of ethylene and 2-norbornene) At room temperature under a nitrogen atmosphere, 15 liters of toluene, 23 mmol of triisobutylaluminum (TIBA), 110 micromol of zirconium tetrachloride, tetrakis were placed in a 30 liter autoclave at room temperature. 150 micromoles of anilinium (pentafluorophenyl) borate were charged in this order, followed by 2.3 liters (15 mols as 2-norbornene) of a toluene solution containing 70% by weight of 2-norbornene. After the temperature was raised to 90 ° C., the reaction was carried out for 110 minutes while continuously introducing ethylene so that the ethylene partial pressure became 7 kg / cm ² . After the completion of the reaction, the polymer solution was poured into 15 liters of methanol to precipitate the polymer. The polymer is filtered and dried,
A cyclic olefin copolymer (a1) was obtained. The yield of the cyclic olefin copolymer (a1) was 3.89 kg. The polymerization activity was 388 Kg / gZr.

The obtained cyclic olefin copolymer (a)
Physical properties of 1) were as described below. 30 of ¹³ C-NMR
The sum of the peak based on ethylene and the peak based on methylene at the 5- and 6-positions of norbornene, which appears around ppm, and 3
The norbornene content determined from the ratio to the peak based on a methylene group at the 7-position of norbornene appearing at around 2.5 ppm was 9.2 mol%. The intrinsic viscosity [η] measured in decalin at 135 ° C. was 0.99 dl / g, and the crystallinity determined by X-ray diffraction was 1.0%. Using a Vibron 11-EA type manufactured by Toyo Boulding Co., Ltd. as a measuring device, a measuring piece having a width of 4 mm, a length of 40 mm and a thickness of 0.1 mm was measured at a heating rate of 3 ° C./min and a frequency of 3.5 Hz. The glass transition temperature (Tg) was determined from the peak of the loss modulus of elasticity (E ″) of the sample, and the Tg was 3 ° C. ALC / GPC150C manufactured by Waters Co., Ltd. was used as a measuring device, and 1,2,4-trichlorobenzene solvent was used. 135 ° C
The weight average molecular weight Mw, number average molecular weight Mn, and molecular weight distribution (Mw / Mn) were calculated in terms of polyethylene.
Mw is 54,200, Mn is 28,400, Mw / Mn
= 1.91. Using a Perkin-Elmer 7 series DSC at a rate of 10 ° C./min, -50 ° C.
When the melting point (Tm) was measured in the range of 150 ° C., the Tm
Was 72 ° C (broad peak).

Reference Example 2 (Copolymerization of ethylene and 2-norbornene) Under a nitrogen atmosphere and at room temperature, 15 liters of toluene, 23 mmol of triisobutylaluminum (TIBA), 38 micromol of zirconium tetrachloride and tetrakis were placed in a 30 liter autoclave at room temperature. 60 micromoles of anilinium (pentafluorophenyl) borate are charged in this order, followed by 2.4 liters of a toluene solution containing 70% by weight of 2-norbornene (16 liters as 2-norbornene).
Mol) was added. After the temperature was raised to 80 ° C., the reaction was carried out for 110 minutes while continuously introducing ethylene so that the ethylene partial pressure became 8 kg / cm ² . After the completion of the reaction, the polymer solution was poured into 15 liters of methanol to precipitate the polymer. This polymer was collected by filtration and dried to obtain a cyclic olefin copolymer (a2). The yield of the cyclic olefin-based copolymer (a2) was 2.93 Kg. The polymerization activity was 845 Kg / gZr.

The properties of the cyclic olefin copolymer (a2) obtained in the same manner as described above were as follows. The norbornene content is 7.7 mol%, the intrinsic viscosity [η] is 1.20.
dl / g, crystallinity 1.0%, Tg 0 ° C., Mw 6
9,600, Mn is 35,900, Mw / Mn is 1.9.
4. Tm was 72 ° C (broad peak).

The cyclic olefin copolymers a1 and a obtained in the heat resistance evaluation reference examples
2. Using high-density polyethylene and linear low-density polyethylene, the same resin is repeatedly pelletized 1 to 5 times at a resin temperature of 160 ° C. with an extruder of 30 mmφ,
The melt index (MI) of the pellets obtained at each pelletizing was measured. MI and 1 before pelletizing
Retention rate of MI after the second and subsequent pelletizing [(MI after pelletizing / MI before pelletizing) × 100
(%)] Are shown in Table 1. MI is JI at 190 ° C.
It was measured according to S-7210.

[0065]

[Table 1]

Next, examples using the cyclic olefin-based copolymer obtained in the above reference example will be described. Example A 140 μm thick film made of the cyclic olefin copolymer (a1 and a2) obtained in Reference Example was formed. Next, the films were stacked and heat sealed on all sides to form a bag of 150 mm × 200 mm. Finally, a cap member made of polypropylene was attached to this bag by heat sealing to obtain a medical infusion bag of the present invention.

As described above, the medical infusion bag of the present invention has high thermal stability without adding a stabilizer,
In addition, since a resin with excellent heat sealability, melt fluidity, and liquid resistance is used, problems such as dissolution of additives do not occur, and since it has elasticity (recovery) properties,
It is useful as a medical member without fear of breaking the bag.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-63-96055 (JP, A) JP-A-4-1010 (JP, A) JP-A-3-275070 (JP, A) JP-A-1- 101347 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61J 1/10 A61L 31/00

Claims (1)

(57) [Claims] 1. A glass transition temperature comprising a repeating unit derived from an α-olefin represented by the following general formula [X] and a repeating unit derived from a cyclic olefin represented by the following general formula [Y]: A medical infusion bag characterized by comprising at least an inner layer of a cyclic olefin copolymer having a (Tg) of 70 ° C. or lower. Embedded image (In the formula [X], Ra represents ^a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms.) (In the formula [Y], R ^{b to} R ^m each represent a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms or a substituent containing a halogen atom, an oxygen atom or a nitrogen atom, and n represents an integer of 0 or more. .R ^j or ^{R k} and ^{R l} or ^{R m} and may form a ring with each other. ^Further, R b to R ^m are each may be the same or different from each other.)