JP2013094119A - Method for exterminating malaria, trypanosomiasis, aids, and hepatitis c, and apparatus for the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a therapeutic means allowing a human body to acquire autoimmunity to a symptom of malaria, HIV, or the like.SOLUTION: A preventing method and a therapeutic method of AIDS, plasmodia and poliovirus include allowing coconut husk activated carbon to adsorb HIV which is the causative virus of a patient with the disease name of AIDS, and grinding the activated carbon freeze-dried or directly, using a grinding means such as a jet mill; and filtering a blood component of whole blood that contains HIV, or a plasma component containing serums and cellulose excluding blood corpuscles from the blood components of whole blood, through a dialysis membrane for an analyzer used for artificial dialysis, for use.

Description

The present invention relates to malaria protozoa, trypanosoma protozoa, viruses, and bacteria that are pathogens such as malaria, influenza, dengue fever, Japanese encephalitis, yellow fever, and sleeping sickness (hereinafter abbreviated as infectious disease). The purpose is to kill a representative mosquito or a tsuetsue fly (hereinafter abbreviated as a mosquito mosquito or a fly fly) by heating it in the air using electromagnetic waves.

Further, the present invention relates to the blood in a human body infected with malaria parasites, trypanosoma protozoa, Costaria schistosomiasis, and rat contracted nematodes (hereinafter abbreviated as malaria parasites or trypanosoma protozoa), or cows and horses. Malaria parasites or trypanosoma protozoa in the body blood of epigallocatechin (EGC), epicatechin (EC), gallocatechin (GC), catechin (C), epigallocatechin gallate (EGCg), epicatechin gallate (ECg) , Gallocatechin gallate (GCg),
And catechin gallate (hereinafter abbreviated as catechin) administered intravenously, intramuscularly, intraperitoneally, and intravenously (hereinafter abbreviated intravenously) to cause infection in the blood The purpose is to kill the malaria parasite or trypanosoma protozoa directly in the blood of the human body and cow and horse.

In addition, the present invention provides for direct venous administration of catechin directly into the blood of agricultural cows that are infected with the parasite Trypanosoma parasite mediated by the fly fly, which is the cause of sleepiness. It aims at providing the treatment method of the sleepiness disease which is doing.

The present invention also provides a means for treating infectious diseases such as AIDS virus (HIV), hepatitis C virus (HCV), influenza virus, or tuberculosis bacteria, or cancer cells (hereinafter abbreviated as infectious diseases). The purpose is to do.

In addition, treating infections (hereinafter abbreviated as infectious diseases) infected by sexual acts such as AIDS virus (HIV), hepatitis C virus (HCV), papilloma virus (HPV), vaginal chlamydia, and syphilis, It is also intended to provide a microbicide that is an intravaginal suppository for protection.

In the past, as a means to prevent the spotted mosquitoes that carry malaria, dengue fever, Japanese encephalitis, and yellow fever (hereinafter, abbreviated as malaria), the human body is stung from a spotted mosquito with a bed of mosquito nets. It is the current situation that is defending.

In addition, it is said that sleeping sickness infects 400,000 people every year in Central Africa and 60,000 people die. This sleepiness is caused by infection with the parasite Trypanosoma protozoa mediated by the blood-sucking fly fly. Beyond humans, farming cattle and horses are infected with sleepy mildew and die, dying. ing.

Furthermore, as a means of treating malaria, there is no therapeutic effect since resistant malaria parasites have emerged for conventional quinine, chloroquine, artesunate, and artemisinin.

At present, there is no therapeutic means for fundamentally treating infectious diseases such as AIDS virus (HIV), hepatitis C virus (HCV) and influenza virus.

In addition, AIDS virus (HIV), hepatitis C virus (HCV), papillomavirus (
HPV), vaginal chlamydia, and remedies to treat infections that are transmitted by sexual activity such as syphilis,
And there is no defense means to protect.

By using electromagnetic waves to kill the mosquitoes that transmit malaria parasites in the human body in the air or by heating and killing the mosquitoes that are stationary, the mosquito net is used to stab the human body from the mosquitoes. As an alternative to protecting the bed with a bed, the need for a mosquito net is eliminated by heating and killing the mosquitoes that are stationary or using an electromagnetic wave in the air.

In addition, the fly flies that mediate sleepiness are clinging to the surface of the cow and horse skin for farming, so that the output electromagnetic waves within the range that does not kill the cow and horse are transmitted to the surface of the cow and horse skin. Agricultural cattle and horses are used by killing, using electromagnetic waves, the fly fly that mediates the trypanosoma protozoa that are responsible for the bedridden disease that causes cattle and horses to infect both cattle and horses. You will be able to cultivate the vast uncultivated farmland in central Africa.

In addition, it provides a means of treating AIDS patients caused by AIDS virus (HIV), which is infected by over 28 million people worldwide.

In addition, we provide microbicide, which is a defensive means to protect and prevent AIDS virus (HIV), which is infected by more than 3 million people per year, at the stage of sexual activity.

Furthermore, it provides a means of treating patients infected with hepatitis C virus, which has more than 2 million infected individuals in Japan alone.

In addition, a means for sterilizing and killing influenza viruses in the air using electromagnetic waves is provided. For example, it provides means for killing and killing avian influenza viruses such as H5N1 infecting highly toxic chickens that infect chickens inside poultry houses.

Furthermore, it exists in the air of living space where people live, for example, air inside public buildings, air inside trains, and air inside the house, for example, sterilizing influenza viruses using electromagnetic waves. And provide a means of killing.

In order to achieve the above-mentioned object, the configuration of the present invention includes an electromagnetic wave oscillated using a magnetron as an oscillation source, a surface wave vibration, a pulse wavelength, and a solid vibration (hereinafter referred to as a crystal resonator for short). The amplified electromagnetic waves are emitted and irradiated in the air, and the mosquitoes or swallows that are intended to be killed using the electromagnetic waves are heated and killed in the air or on the surface of the cow's horse skin. I will do it.

In addition, the name of the disease infected with malaria parasite or trypanosoma protozoa is malaria, or as a means of treating sleeping sickness, it has a strong antioxidant effect in the blood of the human body or the blood of cattle and horses. The catechin, which is easy to bind and has antiviral effect, is directly administered intravenously or intraperitoneally, and the name of the disease in which the human body and the cow are infected is considered to be a treatment for malaria or sleepiness. .

Furthermore, for protozoa such as malaria parasites, mouse Costaria schistosomiasis, Trypanosoma protozoa, and Sperocheta paridae, such as protozoa, bacteria (hereinafter abbreviated as malaria protozoa or trypanosoma protozoa), Quinine, chloroquine, developed as a magic bullet
Resistant malaria parasites have emerged against drugs such as ascofuranone and artemisinin (hereinafter abbreviated as artemisinin). As a treatment method for this resistant malaria parasite, catechin and artemisinin, or catechin and quinine, or catechin and chloroquine were chemically bound by mixing and using catechin and artemisinin together. By making a catechin and artemisinin, or a catechin and quinine, or a catechin and chloroquine mixed drug, the catechin and artemisinin mixed drug becomes an artemisinin derivative property. Artesunate (Artesunate) and catechin, or dihydroartemisinin (dihydroartemisinin) and catechin, or Artemether (artemeta) and catechin,
It becomes the property of artesunate derivatives. Alternatively, when dihydroartemisinin and catechin are mixed, the properties of the dihydroartemisinin derivative are obtained. Alternatively, when Artemeter and catechin are mixed, the properties of Artemeter derivatives are obtained. Alternatively, when quinine and catechin are mixed, the properties of the quinine derivative are obtained. Or, when chloroquine and catechin are mixed, it becomes a drug that is effective against resistant parasites such as resistant malaria parasites or resistant trypanosoma protozoa. The name of the disease that develops can be used as a treatment for malaria or sleepiness.

In addition, AIDS patients infected with AIDS virus (HIV), or hepatitis C virus (HCV)
Viruses in the blood, such as hepatitis C patients who are infected with, or influenza patients who are infected with highly toxic influenza viruses such as H5N1 (hereinafter referred to as AIDS patients for short) Because it contains a large amount of OH groups, it has a strong anti-oxidation effect and easily binds to proteins, chain sugars, and lipids that make up various viruses, tuberculosis bacteria, or cancer cells. In patients with AIDS, hepatitis C, influenza, tuberculosis, or cancer patients who are administered catechins with viral, antibacterial, or anticancer effects directly into the veins of the human body It is supposed to be a therapeutic means.

In addition, papillomavirus (HPV) is the causative virus for cervical cancer that affects more than 3 million people who have been infected by sexual activity per year, or one in three young adult women. Or inactivate bacteria, such as vaginal chlamydia, that cause inflammation inside the trumpet tube, which is the fallopian tube that is infected by one in four young adult women, inside the woman's vagina, Or, for the purpose of sterilization, prevention or defense, vaginal disinfectant which is a vaginal suppository using catechin and hard hat oil or palm oil (hereinafter abbreviated as palm oil) as main raw materials (M
icrobicide) and provided as a means of treating the above infection.

In addition, catechin has a strong effect of killing male sperm by chemically binding to male sperm proteins, chain sugars and lipids, so it can be used by inserting into the vagina from a woman's stand. When a medicine is inserted into a woman's vagina in a solid state at room temperature using catechin and hard hat oil or coconut oil (hereinafter abbreviated as coconut oil) as the main raw materials, By forming a contraceptive that is a vaginal suppository, e.g. in the form of a jelly, or a tablet, or a rocket shape, solubilized at a body temperature inside the vagina, e.g., a temperature of 34 ° C or higher,
AIDS virus (HIV), hepatitis C virus (HCV) described above at the same time as contraception
), Providing a contraceptive characterized by the ability to prevent and protect against infectious diseases such as papillomavirus (HPV), vaginal chlamydia, and syphilis at the stage of sexual activity at the same time as contraception. And

According to the present invention, a new type of highly virulent influenza virus such as H5N1, hepatitis A virus, hepatitis B virus, hepatitis C virus, HTLV-1, AIDS virus, various rotaviruses such as rotavirus, Or bacteria, such as resistant M. tuberculosis, cancer cells, vaginal chlamydia, MRSA, and O157, or protozoa such as malaria parasite, syphilis, and trypanosomiasis catechin, catechin complex, or catechin derivative intraperitoneally, intravenous administration It has the effect of being inactivated or killed by oral administration.

It is a graph which shows evaluation of the experimental result which conducted the experiment regarding antimalarial activity.

It is a graph which shows evaluation of the experimental result which conducted the experiment regarding antimalarial activity similarly to FIG.

It is a graph which shows the experimental result which inactivated the mouse | mouth hepatitis virus which the mouse | mouth infects.

It is a graph which shows evaluation of the experimental result which conducted the experiment regarding anti-influenza virus activity.

It is a graph which shows evaluation of the experimental result which conducted the experiment regarding anti-influenza virus activity.

It is a graph which shows evaluation of the experimental result regarding the effectiveness as a chemical | medical agent of the catechin with respect to the mouse | mouth infected with the herpesvirus of the herpes simplex skin infection model in which a mouse | mouth is infected.

Change in survival rate after drug administration in murine malaria parasite-infected mice

Changes in blood rate of murine malaria parasite-infected mice treated with chloroquine and catechins

Changes in blood rate of mice infected with Plasmodium falciparum administered artesunate and catechins

Measurement figure of fine powder of tea leaves obtained by crushing tea leaves using a stone mill

Measurement figure of fine powder of tea leaves crushed using a ball mill

Measurement diagram of tea leaf fine powder obtained by crushing tea leaves using a jet mill (airflow crushing method)

Measured figure of filtering only the supernatant obtained by filtering the powdered tea served at a sushi restaurant and filtering the powdered tea served at a sushi restaurant.

Range that does not affect the human body or cow and horse in the region from around 2 GHz to around 10 GHz using the oscillation source magnetron, surface wave vibration, pulse wavelength, and solid vibration (hereinafter abbreviated as quartz crystal) An EM mosquito flying in the air by emitting and irradiating the electromagnetic wave amplified by oscillating the electromagnetic wave of the output from the quartz resonator as an oscillation source in the air or on the surface of the cow's body skin, Or the surface of the cowskin's skin is irradiated with microwaves, which are electromagnetic waves, and the mosquitoes or the fly flies are heated to make the protein that constitutes the mosquitoes or the fly flies 60 degrees Celsius
Heat from C to 65 ° C or higher to denature the mosquito mosquitoes or the proteins that make up the fly fly, thereby killing the mosquitoes or fly fly that transmit malaria parasites or trypanosoma protozoa in the air Suppose that it is configured.

This is a US patent publication that describes the processing means invented and discovered by the inventor Yoshiaki Nagaura.
Amplifying electromagnetic waves using a quartz crystal oscillator, which is a solid oscillator capable of oscillating a sinusoidal electromagnetic wave produced by processing the quartz crystal using the processing means for crystal oscillator described in US6,952,074B2, An electromagnetic wave that is an electromagnetic wave in the air by launching and irradiating electromagnetic waves with increased output in the air or on the surface of the cow's body skin and irradiating them. Use heat to kill and kill.

It can be said that a human and a cow and horse are overwhelmingly heavy in the weight ratio at the time of comparing a human and a cow and horse with a mosquito, a fly fly, or an influenza virus by mass. Using this difference in weight ratio, the output of electromagnetic waves within a range that does not affect humans and cattle and horses, and the mosquitoes that transmit malaria parasites using time, or the fly flies that transmit trypanosoma protozoa Alternatively, the influenza virus is killed using microwaves that are electromagnetic waves.

Carnivorous Koshimagengoro, Anopheles mosquito, bee, house fly, yellow fly, and fly fly, whose body length is around 10mm, has a household microwave frequency of around 2.2GHz and an output of 500W
In the case of an electromagnetic wave with an electromagnetic wave density of ˜, it will die in a heating time of about 20 seconds. In the case of an electromagnetic wave with a microwave oven frequency of around 2.2 GHz and an output of 900 W, it will die in a heating time of around 10 seconds. Furthermore, in the case of an electromagnetic wave having an electromagnetic wave density of about 2.2 GHz and an output of 1.5 KW, it will die in a heating time of about 5 seconds. From this, the household microwave oven that was manufactured using the magtron oscillator as the oscillation source was improved, and the door of the household microwave oven was removed, for example, 500 W using an improved household microwave oven, 90
Uses an improved household microwave oven designed to emit or irradiate microwaves, which are electromagnetic waves of 0 W or 1.5 KW, into the air, and mediate malaria parasites whose disease name causes malaria It is assumed that the mosquitoes can be killed in the air while the mosquitoes are flying in the air. In addition, it is possible to kill the fly fly in the air while the fly fly that mediates the trypanosoma protozoa causing the sleepiness disease is flying in the air.

Further, for example, the output of the improved household microwave oven described above is, for example, 500 W
, 900W, or 1.5KW using a modified household microwave oven to raise or radiate electromagnetic waves into the air, using a modified household microwave oven to raise chickens Using an improved household microwave oven inside the house, electromagnetic waves are periodically emitted into the air inside the poultry house, for example, once every 10 minutes for 5 seconds, 10 seconds, or around 20 seconds. 60 degrees Celsius degrees Celsius protein, chain sugar, and lipid that form influenza virus such as toxic H5N1 type that chicken infects by emitting electromagnetic wave inside chicken house for time or irradiating electromagnetic wave By heating and denaturing and decomposing as described above, the inside of the poultry house can always be sterilized using microwaves, which are electromagnetic waves, and the influenza virus can be killed.

Furthermore, as described above, for example, the interior of a house using an improved household microwave oven,
Or use an improved household microwave oven to kill and kill mosquitoes, fleas, lice, mites, and influenza viruses inside public buildings, or inside trains, or inside trains Suppose that a microwave is emitted and irradiated into the interior of the house.

Also, as described above, for example, inside the house that emits and irradiates microwaves that are electromagnetic waves of an improved household microwave oven, circulate the air inside the house and exist in the house It will be used as an air purifier that sterilizes and kills the influenza virus. In addition, the interior of an improved household microwave oven that can emit and radiate electromagnetic waves as an air cleaner such as air inside a public building, or air inside a building, or air inside a train, As described above, air is circulated to kill and kill the influenza virus present in the air.

Polyphenone 70S, manufactured and sold by Mitsui Norin Co., Ltd., headquartered in Tokyo, and Sunphenon BG-3, manufactured and sold by Taiyo Chemical Co., Ltd., headquartered in Yokkaichi, Mie Prefecture, are adjusted concentrations. When (mg / ml) is 500, it has good solubility through a PTFE 0.45 μm filter, so it is administered intravenously or intraperitoneally, and the disease name is malaria, sleepiness, resistant syphilis,
It can be used to treat infectious diseases such as AIDS, hepatitis C, adult leukemia, and influenza.

In addition, as described above, catechin and chloroquine, or catechin and artemisinin (
Catechin and quinine, or catechin and AIDS therapeutic nucleic acid-based reverse transcriptase inhibitor, or catechin and AIDS therapeutic protease inhibitor, or catechin and non-nucleic acid reverse transcriptase When an inhibitor, or a catechin and a non-nucleoside reverse transcriptase inhibitor (hereinafter abbreviated as a treatment drug for malaria or AIDS treatment) is mixed with catechin, chloroquine or artemisinin, which is a treatment drug for malaria, Or quinine, a nucleic acid-based reverse transcriptase inhibitor that is a therapeutic agent for AIDS, a protease inhibitor, a non-nucleic acid-based reverse transcriptase inhibitor, or a non-nucleoside-based reverse transcriptase inhibitor, a chain sugar,
Alternatively, the OH group constituting lipid or protein or protein and catechin is chemically bonded to form a catechin derivative. In particular, catechin has a strong property of chemically binding to proteins. As described above, a combination of artesunate and catechin, which are antimalarial drugs, a combination of chloroquine and catechin, a mixture of artesunate and catechin, a mixture of chloroquine and catechin, or a mixture of AIDS drug and catechin, (For short, a catechin derivative or a catechin complex) is administered intravenously into the human blood, administered intramuscularly, administered intraperitoneally, or administered intravenously Or by oral administration, the name of the disease is malaria, sleepiness, AIDS, hepatitis C, adult leukemia, dengue fever, and highly toxic H
Malaria parasites, trypanosoma protozoa, AIDS virus (HIV), hepatitis C virus (HCV), and influenza viruses that cause infections such as 5N1 influenza (hereinafter abbreviated as infectious disease) in the blood Therefore, it is supposed to be a therapeutic means aimed at killing using a catechin derivative.

Figure 1 shows the collaboration between Mitsuko Norin Co., Ltd., in collaboration with Mr. Kumiko Shintama, who was enrolled in the master's program of Okayama University's Pharmaceutical Information Science Course, and the inventor Yoshiaki Nagaura. Anti-malarial against FCR-3 strain (Plasmodium Falciparum) which is a member of the malaria parasite on January 15, 2008, using a product name of polyphenone 70S with a total content of catechins of 80.7% It is an experimental result of activity evaluation.

Figure 2 shows the names of products manufactured and sold by Mitsui Norin Co., Ltd., described above, jointly by Kumiko Shintama and the inventor Yoshiaki Nagaura. Polyphenon 70
The product name with a total content of 96.7% catechins manufactured and sold by S and Taiyo Chemical Co., Ltd. is a member of the same group of malaria parasites on March 15, 2008, using Sanphenon EGCg. F
CR-3 strain (Plasmodium
falciparum) (hereinafter abbreviated as malaria parasite) is an experimental result of antimalarial activity evaluation.

Considering the experimental results described in FIG. 1 and FIG. 2 above, there is a considerable difference between the experimental results shown in FIG. 1 and the experimental results shown in FIG. But,
The product name with a total content of 80.7% catechins manufactured and sold by Mitsui Norin Co., Ltd. is Polyphenon 70S, and the product name with a total content of 96.7% catechins manufactured and sold by Taiyo Chemical Co., Ltd. Both of the products of Sanphenon EGCg, Polyphenon 70S and Sanphenon EGCg, were found to have antimalarial activity against malaria parasites.

As for the evaluation of antimalarial activity of catechin shown in FIG. 1 and FIG. 2 above, when compared with conventional drugs such as quinine, chloroquine, and artemisinin, which are specific medicines for malaria parasites, The antimalarial activity against Plasmodium was an experimental result that is about an order of magnitude lower. However, quinine, chloroquine, and artemisinin, which are specific medicines for malaria parasites, are highly toxic and have side effects, whereas catechins have no toxicity and no side effects. Therefore, there is an advantage that even if using a single digit or more amount as a therapeutic means, there is no problem even when compared with conventional quinine, chloroquine and artemisinin.

In addition, as shown in the analysis value of Polyphenon 70S manufactured and sold by Mitsui Norin Co., Ltd. and the analysis value of Sunphenon EGCg manufactured and sold by Taiyo Chemical Co., Ltd., catechins are extracted from natural tea. For example, epigallocatechin (EGC)
, Epicatechin (EC), gallocatechin (GC), catechin (C), epigallocatechin gallate (EGCg
), Epicatechin gallate (ECg), gallocatechin gallate (GCg), and catechin gallate (Cg)
) Contains a total of 8 different catechins, so there is no advantage of resistant malaria, resistant AIDS virus (HIV), resistant hepatitis C virus (HCV), resistant influenza virus, resistant chlamydia, and resistant syphilis There is.

Further, the analysis values shown below are those of Polyphenon 70S manufactured and sold by Mitsui Norin Co., Ltd.
September 27, 2007 Results of catechin analysis (HPLC method)
Product Name: Polyphenon 70S
Lot No ： 0704201

The analysis values shown below are the Sanphenon products manufactured and sold by Taiyo Chemical Co., Ltd.
This is the analytical value of EGCg.


March 17, 2008 Sanphenon EGCg Analysis Example
(unit:%)

Also shown below is Polyphenon 70 manufactured and sold by Mitsui Norin Co., Ltd.
S, Sunphenon BG-3 manufactured and sold by Taiyo Chemical Co., Ltd., Sunphenon 90S,
This is a test result of testing whether or not four types of Sanphenon EGCg can be intravenously administered by Shin Nihon Kagaku Co., Ltd. According to the following test results, it was found that polyphenone 70S and sunphenon BG-3 were highly soluble and passed through a PTFE 0.45 μm filter, so that they could be administered intravenously. In particular, polyphenone 70S and sunphenon BG-3 are highly soluble and have been found to be able to be administered intravenously.
January 21, 2008

Furthermore, the test results shown below are the results of a solubility test of sunphenone EGCg, which was requested from Shin Nihon Kagaku Co., Ltd., also explained above. Sanphenon EGCg is a test result that proved to be unsuitable for intravenous administration due to its low solubility.
March 26, 2008

Further, the analysis values shown below are those of Sanphenon BG-3 manufactured and sold by Taiyo Chemical Co., Ltd.
April 7, 2008 Example of catechin composition of Sanphenon BG-3
(unit:%)











that's all

The analysis values shown below are the Sanphenon products manufactured and sold by Taiyo Chemical Co., Ltd.
The analysis value is 90S.
June 30, 2008 Sanphenon 90S Analysis Example
(unit:%)

Furthermore, it is possible to judge from the results of the four types of solubility tests described above, Polyphenon 70S, Sunphenon BG-3, Sunphenon 90S, and Sunphenon EGCg, which were requested from Shin Nippon Science Co., Ltd. It has been found that when the content of epigallocatechin gallate (EGCg) is 52.2% or more of the total catechin content, the solubility in an aqueous solution becomes poor. It was also found that the solubility in an aqueous solution was poor when the content of caffeine was large. From this, it was found that when intravenous administration, the ratio of epigallocatechin (EGCg) to total catechin content is 52.2% or less, and the catechin content is optimal for intravenous administration. . For example, two types of polyphenone 70S with an epigallocatechin gallate (EGCg) content of 32.2% and sunphenone BG-3 with an epigallocatechin gallate (EGCg) content of 41.7% are optimal for intravenous administration. It was the test result of the test which can judge.

July 24, 2008 Results of catechin analysis (HPLC method)
Product name: Polyphenon CG
Lot No: 0612224

In addition, as described above, polyphenone CG or sunphenone 90S has a total catechin content, and polyphenone CG has caffeine as shown in the report of (0055) catechin analysis results (HPLC method). Contain 5.4%. The Sanphenon 90S is (0051)
As shown in the report of the analysis value example of Sanphenon 90S, 5.0% of caffeine is contained. This polyphenone CG and sunphenon 90S, polyphenone 70S and sunphenon
Report on solubility of BG-3 in 4 types of physiological saline or aqueous solution (0044
). As reported in the report from Shin Nihon Kagaku Co., Ltd., Polyphenon CG,
In contrast, the adjusted concentration of both 125 mg / ml and sunphenone 90S is 125 mg / ml, whereas polyphenone 70S and sunphenone BG-3, which do not contain caffeine at all, have a physiological concentration of 500 mg / ml. Hereafter, a report of dissolution in water for injection) (0
050) is a report from Shin Nihon Kagaku Co., Ltd. It can be judged from this report that, when various catechins are administered intravenously, various catechins that do not contain caffeine at all are better soluble. Therefore, when various catechins are administered intravenously, intravenous administration of various catechins not containing caffeine at all may be a necessary condition for intravenous administration of various catechins. The results of the tests on the solubility of various catechins requested by Shin Nihon Kagaku Co., Ltd. were revealed.

Furthermore, the 11 types of catechins shown in Table 8 below are catechin reagents with a purity of 98% or more, manufactured and sold by Nagara Science Co., Ltd., headquartered in Gifu City. 98% of this
The properties of catechin with the above purity are in a white crystalline state that does not dissolve in an aqueous solution and are hydrophobic in nature. It has the property of dissolving only in methanol, methyl alcohol, ethanol, or ethyl alcohol (hereinafter abbreviated as methanol). Therefore, in order to administer catechin intravenously, the catechin must be dissolved in an aqueous solution so that it is necessary to use a catechin whose concentration is reduced to 98% or less. Purity is 9
As a method for diluting by dissolving 8% or more of catechin in an aqueous solution, for example, the following 11 types of catechins in a crystalline state having a concentration of 98% or more of catechin are purified and then dissolved in an aqueous methanol solution. Then, after diluting with an aqueous solution, the concentration of catechins containing catechins with a purity of 98% or higher is obtained by removing toxic methanol by heating or using other means. Any aqueous solution can be adjusted. For example, even if the concentration of catechin is 50% or less or 60% or less, the concentration of catechin can be freely adjusted to any concentration, so the following (1), (2), (3), ( There are effects as in 4) and (5).

The advantage of (1) is that catechins with a purity of 98% or higher are used,
A small amount of impurities.

The advantage of (2) is that catechins with a purity of 98% or more are used,
Since it is a colorless and transparent aqueous solution, toxicity can be removed without limit.

The advantages of (3) are the effects of a single catechin such as the antibacterial effect, anticancer effect, antiviral effect, antimalarial protozoa effect, and antitrypanosome protozoa effect of the 11 types of catechins shown below Therefore, it is easy to obtain an evaluation as a pharmaceutical because a highly accurate therapeutic effect can be obtained.

Shown below is Table 8 described above.

As an advantage of (4), a catechin having a purity of 98% or more can be adjusted, and a catechin having an arbitrary concentration of catechin can be adjusted. Therefore, a PTFE filter or PVD can be used.
It can be adjusted to a concentration of 500 (mg / ml) catechin that can pass through a 0.45 μm filter made of F, for example, the concentration of catechin is 40% or less.

As an advantage of (5), after catechin having a purity of 98% or more is dissolved in methanol, catechin and hard hat oil or coconut oil dissolved in methanol (hereinafter referred to as catechin)
Abbreviated as coconut oil for short), then heating the solvent methanol used to dissolve the single product with catechin purity of 98% or more as described above, or using other means Catechin from which methanol has been removed and vaginal sterilizer (Microbicide), a vaginal suppository made mainly of palm oil, or vaginal sterilizer that also functions as a contraceptive to be inserted into the vagina are colorless and transparent. Since it is white, there is an advantage that clothes are not soiled. The conventional catechin is not a single product but a mixture of several types of catechins and the purity is low, so the color of conventional catechins is brown or black. There is a fault that colors and stains the color.

In addition, as described above, catechin and chloroquine, or catechin and artemisinin,
Alternatively, when a drug such as catechin and quinine is mixed at a certain ratio, a catechin derivative that is a complex of catechin and chloroquine, catechin and artemisinin, or catechin and quinine is completed. The characteristics of this catechin derivative are that, unlike catechin alone, the catechin derivative is absorbed in the human intestinal tract without being decomposed in the stomach and intestinal tract, which are the digestive organs of the human body. Although it can be administered internally, it is optimal for oral administration.
Moreover, since this catechin derivative is a mixture of several types of catechins or 8 types of catechins and chloroquine, artemisinin, and quinine, there is an advantage that resistant malaria parasites, resistant trypanosoma protozoa, or resistant AIDS virus cannot be produced.

In addition, as described above, catechin and AIDS therapeutic nucleic acid reverse transcriptase inhibitors Retrovir, Zidovudine, AZT, Vadex, didanosine, ddI, Hibid, ddC
, Epivir, lamivudine, 3TC, zelit, stavudine, d4T, combivir, ziagen, and abacavir sulfate, or the AIDS drugs clixiban, novia, ritonavir, biraceptate, mesylate, nelfinavir, prose, amprenavir, fort base, saquinavir, Catechin of Kaletra, lopinavir, and ritonavir, or non-nucleic acid reverse transcriptase inhibitor viramune, nevirapine, stockrin, efavirenz, rescriptor, and delavirdine mesylate, or non-nucleoside reverse transcriptase inhibitor When it is mixed with and chemically bonded, it becomes a drug active against resistant AIDS virus.
Table 9 below shows the names and product names of manufacturers of AIDS drugs.

In addition, when catechin is administered intravenously or orally, particularly when catechin is administered orally, 11 types of catechins described in (0055) above or manufactured by Mitsui Norin Co., Ltd. Polyphenon 70S and Polyphenon CG sold, or Sunphenon BG-3, Sunphenon 90S and Sunphenon EGCg manufactured and sold by Taiyo Chemical Co., Ltd.
In the case of conventional oral administration of various types of catechins (hereinafter abbreviated as various catechins, or catechins, or catechins), such as intravenous administration, intramuscular administration, and intraperitoneal administration And the difference from the case of intravenous administration (hereinafter abbreviated as intravenous administration)
Since various catechins have the disadvantage that they are degraded in the digestive organs of the human body, for example, the stomach or small intestine and are not easily absorbed by the intestinal tract, various catechins are absorbed in the digestive tract even if administered orally. There are very bad drawbacks. In the conventional catechins, the absorption rate of various catechins is poorly absorbed in various catechins. For example, 10% of catechins having a certain ratio, for example, 9 by weight ratio and 1: 9 or less of 1: 9. The following ratio, or the ratio of various catechins is 8, and the ratio of caffeine is 2: 8 or less, 20% or less, or the ratio of various catechins is 7, and the ratio of caffeine is 3, 3: 7 or less, 30% or less. The ratio, or the ratio of various catechins is 6, and the ratio of caffeine is 4: 6 or less of 40% or less, or the ratio of various catechins is 5 and the ratio of caffeine is 5 or 5: 5 or less of 50% or less, Alternatively, the ratio of various catechins is 4 and the ratio of caffeine is 6: 4 or less, 60% or less of 6, or the various catechins is 3, and caffeine is 7
: Ratio of 3 or less, 70% or less, or 2 for various catechins, 8: 8 or less of 8: 2 for caffeine, or 80% or less for caffeine, or 1 for various catechins, 9: 9 for caffeine In the following 90% ratio,
When various catechins mixed with caffeine mixed with various catechins (hereinafter abbreviated as various catechins containing caffeine or catechin derivatives) are administered orally, various catechins are strongly chemistry with caffeine. It has the property of chemically bonding. The effects of various catechins containing caffeine obtained by chemically bonding these various catechins and caffeine include the following (1), (
2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) , (15), and (
There is an effect like 16).

As an effect of (1), as an advantage of various catechins containing caffeine, it has a property that it is difficult to be decomposed in the stomach or small intestine that is the digestive organ of the human body, or a property that is not decomposed in the digestive organ.

As an effect of (2), as an advantage of various catechins containing caffeine, it is easily absorbed into human blood in the intestinal tract, which is the digestive organ of the human body.

As an effect of (3), the advantages of various catechins containing caffeine are as follows. It can be used as a drug for therapeutic means such as hepatitis, influenza, chlamydia, ringworm, vesicularis, tuberculosis, and cancer cells. Moreover, the effect as a chemical | medical agent has the effect as a chemical | medical agent similar to various conventional catechins. However, the solubility in physiological saline or aqueous solution deteriorates in proportion to the content of caffeine, so it cannot be used for intravenous administration or should be used for intravenous administration. It becomes difficult to do. However,
If the caffeine content is 5% or less of the total weight of the total catechin content of various catechins, the solubility in physiological saline or aqueous solution will be worse, but somehow Intravenous administration is possible. However, it can be said that the caffeine content is 5% or more based on the total weight of the total catechin content.

The effect of (4) is that each caffeine-containing catechin for oral administration has the advantage that it can be easily used in the syrup state, capsule state, or tablet state even when taken by an infant or adult. Can be drunk.

As an effect of (5), as an advantage of each catechin containing caffeine administered orally,
After being absorbed into the human blood by the intestinal tract, which is the digestive organ, it is easily decomposed by the human liver.

As an effect of (6), the content of caffeine with respect to the weight ratio of the total catechin content of natural tea catechin is, for example, an analysis of Sunphenon 90S of Taiyo Kagaku Co., Ltd. shown in (0047) As shown in the value, 5.0% of caffeine is contained with respect to the total weight of the total catechin content. Also, polyphenon CG from Mitsui Norin Co., Ltd. shown in (0049)
As shown in the analysis result of catechins (HPLC method), the total catechin content is 5.
The reason why it contains 4% caffeine is that it is difficult to decompose in the intestinal tract, which is the digestive organ of the human body. It is also the reason why it is easily absorbed in the intestinal tract. Furthermore, it is also a reason why it is easily decomposed in an organ such as a human liver.

The effect of (7) is that, as described above, when orally administered, 5% or more of caffeine relative to the total weight of the total catechin content is added to the total weight of the total catechin content. On the other hand, when caffeine is mixed, it becomes more difficult to be decomposed in the intestinal tract, which is a digestive organ. Also,
It is easily absorbed in the intestinal tract. Furthermore, since it is easily decomposed by the liver of the human body, the effect as a medicinal effect is further enhanced.

The effect of (8) is, as described above, the content of caffeine with respect to the total catechin content of various catechins, for example, polyphenone CG having a caffeine content of 5.4%, and caffeine Solubility in saline or aqueous solution in the case of 5% of Sanphenon 90S, and in saline or aqueous solution of Polyphenone 70S and Sanphenon BG-3 that do not contain caffeine at all (0044) shows the result of an experiment in which a solubility experiment was conducted by requesting Shin Nihon Kagaku Co., Ltd. to conduct an experiment for comparison of the solubility. According to a report of the experimental results, it was found that polyphenone 70S and sunphenone BG-3 which do not contain caffeine at all have good solubility. It was also found that polyphenone CG and sunphenone 90S containing caffeine have poor solubility.

As the effect of (9), the solubility of Sunphenon EGCg manufactured and sold by Taiyo Kagaku Co., Ltd. shown in (0049) above using physiological saline or aqueous solution is A report of the results of experiments conducted on the solubility of Sanphenon EGCg by requesting Japanese science (
0047). It can be judged from the report of the experimental results shown in (0051) that the solubility of sunphenone EGCg whose content of epigallocatechin gallate (EGCg) is 92.7% of the total catechin content is It turned out to be bad. From this, in the physiological saline or aqueous solution of polyphenone 70S having a low epigallocatechin gallate (EGCg) content of 32.3% and Sanphenon BG-3 having a low epigallocatechin gallate (EGCg) content of 41.7% It was found that the solubility was good. From the above, when various catechins are administered intravenously, the content of epigallocatechin gallate (EGCg) is 41.7% or less, or 92.7% or less by weight ratio to the total catechin content of various catechins. Epigallocatechin gallate (E
Various catechins containing GCg) were found to be optimal for intravenous administration.

The effect of (10) is as described above, with respect to the total catechin content of various catechins, the greater the content of epigallocatechin gallate (EGCg), the more antiviral activity, or antimalarial protozoan activity. Antioxidant activity such as anti-trypanosoma protozoa activity, bacteria or tuberculosis killing effect, or anti-cancer effect, the stronger the epigallocatechin gallate (EGCg) content, the stronger the antioxidant effect That is clear. However, as explained above, Sunphenon EGCg manufactured and sold by Taiyo Chemical Co., Ltd., which has a large content of epigallocatechin gallate (EGCg), has a content of epigallocatechin gallate (EGCg). Since the content is as high as 92.7% with respect to the total catechin content of various catechins, there is a drawback in that it cannot be administered intravenously because it does not dissolve in physiological saline or an aqueous solution. This epigallocatechin gallate
As a means to avoid the disadvantage that the solubility becomes worse as the content of (EGCg) is larger, by reducing the content of epigallocatechin gallate (EGCg) contained in the total catechin content of various catechins It has been found that the solubility in a physiological saline solution or an aqueous solution for intravenous administration is good.

As the effect of (11), the characteristics of various catechins described above are high in reactivity with substances containing iron or iron (hereinafter abbreviated as iron). Is administered orally or intravenously, various catechins containing various catechins and iron that is chemically bonded to iron by chemical reaction (hereinafter abbreviated, various catechins containing iron,
(Or catechin derivatives) orally or intravenously, various catechins containing iron that are chemically bound to iron are decomposed in the digestive organs of the human body, such as the stomach and small intestine. Since various catechins containing iron are absorbed in the intestinal tract, they can be used as a treatment method for various infectious diseases described above.

As an effect of (12), as a means of treatment for farming cattle infected with trypanosoma, a parasite borne by the fly fly, whose disease name is the cause of the infectious disease of sleepy mildew, and domestic animals such as horses or pigs The catechins or catechin derivatives described above are administered orally, or administered intraperitoneally, or administered intravenously, for farming cattle and horses,
Alternatively, livestock such as pigs are infected, and the name of the disease is used as a means of treating sleepiness.

The effect of (13) is that the various catechins described above are orally administered intraperitoneally, intraperitoneally, or intravenously, so that the disease name is influenza However, Japanese encephalitis, dengue fever, and yellow fever can eradicate viruses that are strains of the coronavirus, a porcine-derived virus from which pigs are the source of infection. This swine-derived influenza virus, dengue fever, yellow fever, and Japanese encephalitis virus that develops mosquitoes that are mosquitoes are transmitted to humans and birds, etc., the disease name is influenza, Yes, yellow fever, Japanese encephalitis. From this, the disease name is influenza, dengue fever, yellow fever, Japanese encephalitis (hereinafter referred to as influenza for short) is also a coronavirus companion that swine is a carrier, so the disease name eradicates influenza If eradicating swine-derived flu from the body of a pig that is a carrier, the name of the disease can eradicate the flu. In addition, the disease names Dengue, Yellow Fever, and Japanese Encephalitis can be eradicated just like influenza. In order to eradicate the virus that is a member of the coronavirus derived from swine from the body of the pig, various catechins and catechin derivatives (hereinafter referred to as catechin for short) described above are incorporated into the body of the pig. For example, by oral administration, which is a therapeutic means for feeding catechin from the mouth of pigs, or by intraperitoneal administration, or intravenous administration, from the earth, swine coronavirus It is possible to eradicate viral diseases such as influenza, avian influenza, dengue fever, yellow fever, and Japanese encephalitis.

The effect of (14) is that catechin is administered orally, intraperitoneally, or intravenously. As a therapeutic means, catechin is administered orally, intraperitoneally, or intravenously to be a therapeutic means for patients with resistant M. tuberculosis.

As an effect of (15), cancer cells floating in the blood by administering catechin orally, intraperitoneally, or intravenously are used to treat cancer cells using the anticancer effect of catechin. As a therapeutic means aimed at killing and preventing cancer cell metastasis in the blood,
Catechin is used as a therapeutic means for cancer patients by oral administration, intraperitoneal administration, or intravenous administration.

As an effect of (16), catechin chemically and covalently binds to proteins, chain sugars, and lipids constituting male semen. By using this phenomenon, a contraceptive for the purpose of contraception intended to inactivate semen in the woman's vagina by the woman's position, the main ingredients are catechin and hard hat oil, or catechin With palm oil as the main raw material, it has the effect of forming a contraceptive that women can use inside the vagina.

Table 10 shown below is manufactured and sold by Associate Professor Akira Ishii in the Department of Infectious Diseases, Hamamatsu Medical University, and Taiyo Kagaku Co., Ltd., located in 1-3-1 Takaramachi, Yokkaichi, Mie Prefecture. The product name is Sanphenon BG-3 ((0046) shows an example of catechin composition of Sanphenon BG-3) and Mitsui Norin Co., Ltd. located in 1-2-9 Nishishinbashi, Minato-ku, Tokyo We use two types of catechins (hereinafter abbreviated as catechins) of polyphenone 70S that is manufactured and sold ((0042) shows catechin analysis results (HPLC method) for polyphenone 70S). The
Table 10 below shows the experimental results for anti-malaria using mice that were asked to experiment with anti-malarial activity against malaria parasites infected by mice.

In addition, a report on the results of the experiment from Associate Professor Akira Ishii to the inventor Yoshiaki Nagaura below, and two types of catechins, Sanphenon BG-3 and Polyphenon 70S described above in Table 10 below, are used. The experimental result of antimalarial action is shown.

Also shown below is a report from Associate Professor Akira Ishii to the inventor Yoshiaki Nagaura, explained above.

Sent: July 23, 2008 17:44
Attachment: Catechin.xls
Subject: Catechin Results

Furthermore, Table 10 shown below is an experimental result of the antimalarial action of catechin requested to Associate Professor Akira Ishii explained above.

The experimental results of the experiment using the mouse shown in Table 10 above will be described below.
Artesunate (Art) 2mg / kg x
2 / day x3days Chloroquine (CQ) administered orally from day 4 of infection 20mg / kg x
1 / day x 3days Sanphenon BG-3 (EGCs) administered orally from day 4 of infection
50 mg / kg x 2 / day x 3days Polyphenon 70S (Poly70S) administered intraperitoneally from the fifth day of infection 50 mg / kgx2 / dayx3days Intraperitoneally administered from the fifth day of infection
When EGCg 500 mg / kg was intraperitoneally administered twice a day on the fourth day of protozoan infection, 13 of 15 mice died the next day.
When 500 mg / kg of Poly70S was intraperitoneally administered twice a day on the fourth day of protozoal infection, 9 of 15 mice died on the following day.

As the experimental plan, artesunate, chloroquine and catechins were to be administered simultaneously from the fourth day of infection with Plasmodium.
However, catechin 500mg / kg
The plan was changed because x 2 / day had more side effects than expected and most mice died.
That is, 5 mice in the infection control group and artesunate alone and chloroquine alone administration groups were used, and catechin administration was sent for 1 day and started.
As a result, the number of mice was small and the test could not be performed, but in particular, the combined effect of artesunate and sanphenone was recognized.
If the protozoa relapses, the mouse will die when the infection rate is low. However, in the combined mice, the survival period was prolonged, and furthermore, there was no death when the infection rate was low.
From this, it is suggested that the effect becomes clearer by taking a longer administration period of sanphenone and administering it at the same time as artesunate.

Moreover, according to the experimental result using the malaria parasite which the mouse | mouth which the mouse | mouth which infects the mouse | mouth infected as shown in Table 10 demonstrated above was demonstrated, with respect to the malaria parasite which a mouse | mouth infects,
-3 (EGCg) alone, two combinations of chloron and sunphenone BG-3 (EGCg), and a combination of artesunate and sunphenone BG-3 (EGCg) are used to prevent malaria parasites that infect mice. It turned out to be effective against this. In particular, Artesunate and Sanphenon BG-3 2
Table 10 shows a report of experimental results from Associate Professor Akira Ishii that the possibility of the combined effect of the drugs used in combination was confirmed.

Furthermore, the results of the experiment shown in Table 10 and the results shown in FIG. 1 and FIG. 2 on January 15, 2008, which were requested by Mr. Kumiko Shintama of the Okayama University Pharmaceutical Information Science Course, In v using the FCR-3 strain (Plasmodium falciparum), one of the malaria parasites, on March 15, 20
Experimental results of antimalarial activity evaluation with itro and infestation of malaria parasites infected by mice requested to associate professor Akira Ishii
Table 10 shows a report that the experimental results of animal experiments using mice in vivo are in agreement.

In addition, it was found from the experimental results shown in Table 10 that catechin and artesunate (artesunate is a substance in which hydrophobic artemisinin is made hydrophilic and water-soluble) are antioxidant substances that generate free radicals. It is basically the same substance.

Furthermore, the experimental results shown in Table 10 revealed that the malaria parasite used in this experiment was a resistant malaria parasite that had no effect as a drug against three kinds of drugs, quinine, chloroquine, and artesunate. I use it. Table 10 Artesunate (Art)
And chloroquine (CQ) administered alone, as shown in the experimental results of Table 10, combined use of artesunate (Art) and catechin (hereinafter abbreviated as catechin derivative or Ernest derivative), or chloroquine When comparing the results of two types of experiments (CQ) and catechin combined (hereinafter abbreviated as catechin derivatives or chloroquine derivatives), Artesunate (Art)
And catechin derivatives, artesunate derivatives, and chloroquine derivatives are more resistant to administration of artesunate (Art) and chloroquine (CQ) than to administration of chloroquine (CQ) alone. The experimental results shown to be effective against malaria parasites are the experimental results in Table 10.

In addition, as described above, artesunate (Art) and chloroquine (CQ) are more catechin derivatives than artesunate (Art) and chloroquine (CQ). The effects on resistant malaria parasites were more effective than catechin and catechin and artesunate (Art) and catechin and chloroquine (CQ). Group (C
OOH) and a hydroxyl group (OH group) undergo a condensation reaction which is a chemical reaction, and catechin and artesunate (Art) are condensed. Alternatively, catechin and chloroquine (CQ) were able to produce an effect on resistant Plasmodium that has no effect as a drug.

Furthermore, since catechin is highly reactive, catechin, quinine, and artesunate (Art)
It is also possible to inactivate resistant malaria parasites using a drug that is a mixture of these three types. Alternatively, the resistant malaria parasite may be inactivated by using a mixture of catechin and artesunate (Art), chloroquine (CQ), and quinine.

In addition, sleepy diseases that are human-onset sleep diseases, wild animals, or cattle, by infection with Trypanosoma protozoa carrying pathogens that are closely related to the fly fly
Dr. Gakuzo Tamura of the Department of Agricultural Chemistry, University of Tokyo, is a filamentous fungus that is a type of mold that causes disease in plants. Ascochlorin was found in 1968 as a substance exhibiting antiviral activity. In 1972, a substance with a slightly different chemical structure was found and named Ascofuranone. It was found that this ascofuranone has a significant effect on sleep disease and Nagana disease.
Founded by Professor Kiyoshi Kita of the Department of International Health Sciences at the University of Tokyo Graduate School of Medicine. A drug in which two types of this ascofuranone and catechin are mixed (hereinafter abbreviated as an ascofuranone derivative or a catechin derivative), or a drug in which three types of ascofuranone, catechin and artesunate are mixed (hereinafter, Abbreviated ascofuranone derivative or catechin derivative), or a drug in which four kinds of ascofuranone, catechin, artesunate, and chloroquine are mixed (hereinafter abbreviated as ascofuranone derivative or catechin derivative) Or ascofuranone, catechin, artesunate, chloroquine and quinine mixed drugs (hereinafter abbreviated as ascofuranone derivative or catechin derivative) sleep disease,
When used as a drug for the treatment of Nagana disease, there is an avoidance effect against resistant trypanosoma protozoa that can be produced when Ascofuranone is used alone to treat Sleep Disease and Nagana Disease.

Furthermore, the ascofuranone derivative described above has a condensation reaction between the hydroxyl group constituting the ascofuranone (OH group) and the hydroxyl group constituting the catechin (OH group). Since catechin is condensed to synthesize an ascofuranone derivative, the ascofuranone derivative has a complex chemical structural formula and has an effect of avoiding the resistance to trypanosoma protozoa.

The discovery of Trypanosoma protozoa that causes sleep sickness was observed in 1680 by the Dutch naturalist Lee Wenhoek, who observed a number of small animals moving around in the intestine's intestines at high speed.

In addition, the name Trypanosoma protozoa found a parasite that Hungarian-born doctor David Grubi had never seen in 1843 while observing sputum blood. I named it Trypanosoma because the spiral movement looked like a bottle of wine.

In addition to India, North Africa, the Middle East, East Asia, and Latin America have a disease called Surah's disease. This is caused by various animals such as horses, donkeys, cattle, and buffaloes, and in the acute case, most people die unless treated. A veterinarian, Griffith Evans, who worked in India in 1880, found trypanosoma protozoa in the blood of a horse and camel with Sura disease. This pathogen is called Evans trypanosoma in the name of the discoverer.

Furthermore, as the main vector species of fly fly, infection is caused by the fly fly of the type Grossina morsitans that infects the pathogens of Bruce trypanosomes and Rhodesia trypanosomes. Grossina parpalis, a type of fly fly, infects Gambia trypanosoma pathogens.

In addition, trypanosoma protozoa are characterized by unicellular protozoa that multiply outside the cell by two divisions. The size is 20 to 30 μm in length, the width is 1.5 to 3.5 μm, and the shape is a spindle shape. The structure has a nucleus in the center and an organ called kinetoplast (motor nucleus) near the end, which contains large DNA. Flagella begins near Kinetoplast,
The cytoplasm is invaded through a hole like a pot called flagella pocket.

In addition, Chagas disease is a disease caused by the infection of cruise trypanosoma and occurs throughout Latin America sub-Mexico. It is estimated that nearly 20 million people are infected. It is also called poverty because many occur among people living in poor houses with earthen or thatched roofs. The parasite that infects pathogens is held by the nocturnal large blood-sucking insect turtle that lives in soil. Sand turtles have the habit of sucking blood while humans are sleeping at night and then dropping them. When a person bites a turtle and feels pain, the Trypanosoma cruzi in the stool invades through the mucous membrane and becomes infected. Another infection route is caused by blood transfusion.

In addition, leishmaniasis is an infectious disease that is transmitted by the same Trypanosoma protozoa as the pathogens of sleep disease and Chagas disease.

Further, the catechin alone shown in Table 10 described above (hereinafter abbreviated as catechin alone) or a combined use of catechin and artesunate (hereinafter abbreviated as catechin derivative or artesunate derivative), or The drug of combined use of chloroquine and catechin (hereinafter abbreviated as catechin derivative or chloroquine derivative) is infected with Trypanosoma protozoa, which are described above, and are carried by the fly flies that are similar to abu. Due to sleep diseases that are human-onset sleep diseases, or due to Trypanosoma protozoa, wild animals, or Nagana disease that cattle, horses, goats and other domestic animals are infected with Trypanosoma protozoa, Or India, North Africa, the Middle East, East Asia, and Latin America have a disease called Surah's disease. This surah disease also occurs in various animals such as wild animals, horses, donkeys, cattle, and buffalos. This Surah disease is also caused by Trypanosoma protozoa as well as sleep diseases.
This pathogen is also caused by Trypanosoma protozoa. Chagas disease is caused by a protozoan of Trypanosoma cruzi, which is carried by sour turtles. Furthermore, leishmaniasis is an infectious disease that is transmitted by Trypanosoma protozoa. As explained above, sleep diseases, Nagana disease, Surah disease, which are caused by Trypanosoma protozoa,
Chagasin disease and leishmania disease (hereinafter abbreviated as sleeping sickness), catechin alone,
It has been found that artesunate derivatives and chloroquine derivatives have significant drug effects.

In addition, since Trypanosoma protozoa that develop sleep diseases caused by Trypanosoma protozoa as described above is a parasite that grows directly in the blood of the human body and animals, Trypanosoma protozoa is blood. A parasite that floats inside and grows directly in the blood. Plasmodium is a parasite that grows inside red blood cells. When both are compared, it is very difficult to inactivate the malaria parasite because it is hidden inside the red blood cells, but it is very difficult to inactivate the malaria parasite. This is also because it has been found that it is easier to inactivate Trypanosoma protozoa than to inactivate Malaria parasites, because it grows directly. Furthermore, since the syphilis pathogen Spirochetaparida or resistant Spirochetaparida parasite is a parasite that floats in the blood and proliferates, catechin alone, catechin that inactivates malaria parasite, just as inactivated Trypanosoma protozoa It has been found that the derivatives, artesunate derivatives, and chloroquine derivatives also have significant pharmaceutical effects on the syphilis pathogen Spirocheta parida or resistant Spirocheta parida parasite.

In addition, a group of Prof. Yusuke Wataya from Okayama University Graduate School synthesized a new compound (N251) similar to the chemical structure of the existing drug artemisinin (also known as artesunate), which was developed as a treatment for malaria. By mixing and using this (N251) and catechin,
N251) and catechin undergo a condensation reaction similar to a chemical reaction, resulting in a condensation bond.
(N251) will become a new and more complex new compound, which has the effect of preventing the occurrence of resistant malaria parasites, and at the same time using (N251) similar to artemisinin alone, When similar (N251) and catechin are used in combination, the effect as a drug such as (1), (2), (3), (4), and (5) below is more More effective.

(1) As a drug, Artemisinin-like new compound (N251) inactivates various viruses such as AIDS virus, influenza virus, papilloma virus, rotavirus, norovirus, and herpes as well as artemisinin There is an effect that can be done.

Regarding the effect of (2) as a drug, a new compound (N251) similar to artemisinin has an anticancer effect against various cancer cells.

The effect of (3) as a drug is due to sleep disease that develops due to Trypanosoma protozoa mediated by the fly, or Nagana disease that also develops in cattle, horses, goats and other domestic animals due to Trypanosoma protozoa, Artemisinin-like new compound (N251) is effective for diseases such as leishmaniasis that develops due to protozoa that mediates syphilis, or syphilis that develops due to protozoa of Spirocheta paridae.

The effect of (4) as a drug is that a new compound (N251) similar to artemisinin and 11 types of catechins shown in (Table 8) (hereinafter abbreviated as catechin) are mixed and used together. Then, artesunate (hereinafter abbreviated as artemisinin) and artemisinate used in the experiment to inactivate malaria parasites at Hamamatsu Medical University shown in (Table 10) and catechin Similar to the combined experimental results, artemisinin-like (N251), which is similar to artemisinin-like (N251)
The combination of 51 ”and catechin is more effective as a drug.

The effect of (5) as a drug is as described above in (1), (2), and (3), using a new compound (N251) similar to artemisinin alone, AIDS virus, influenza virus, When inactivating various miscellaneous viruses such as papillomavirus, rotavirus, norovirus, and herpes, the artemisinin-like new compound (N251) and the artemisinin-like new compound (N251) are used rather than the artemisinin-like new compound (N251) alone. It is better to mix and use catechin together
More effective as a drug. In addition, the anti-cancer effect described in (2) above is also
Compared to the use of a new artemisinin-like compound (N251) alone, the combined use of artemisinin-like new compound (N251) and catechin is more effective as a drug. Furthermore, sleep diseases that develop due to Trypanosoma protozoa mediated by the fly fly described in (3) above, Nagana diseases that also develop protozoa caused by Trypanosoma protozoa, or protozoa that are mediated by Sashichobue New artemisinin-like compound (N251) rather than using artemisinin-like new compound (N251) alone for leishmaniasis that develops due to symptom or syphilis caused by spirochete parida parasite The combination of catechin and catechin is more effective as a drug.

Further, it was found from the experimental results shown in Table 10 that the mice used in the experiments shown in Table 10 are artemisinin (hereinafter abbreviated) and artesunate resistant mice that are resistant to chloroquine. And chloroquine resistant mice were used in the experiments. As a result, ICR Non-treatme shown in Table 10 for both artesunate and chloroquine
As with nt (Control), both artesunate and chloroquine were found to have no effect as drugs on artesunate-resistant mice and chloroquine-resistant mice.
In particular, the experimental results in Table 10 prove that artesunate has no effect on artesunate-resistant mice.

Furthermore, it is possible to judge from the experimental results in Table 10 explained above.
Catechin is a substance that easily causes chemical reactions and condensation reactions with various proteins, sugar chains, lipids, and fatty acids. In particular, catechin causes a condensation reaction with substances containing proteins, sugar chains, lipids, and fatty acids, and changes the composition of the partner substance that has caused a condensation reaction with catechins.
A derivative of the partner substance that has undergone a condensation reaction with catechin, or a complex of the partner substance (hereinafter abbreviated as a derivative of the partner substance, a catechin derivative, or a catechin complex) is formed. For example, judging from the experimental results shown in Table 10, catechin and artesunate undergo a condensation reaction to cause catechin derivatives or artesunate derivatives (hereinafter abbreviated as catechin derivatives or artesunate derivatives), or catechins and chloroquine condense. By causing a reaction to form a catechin derivative or a chloroquine derivative (hereinafter abbreviated as a catechin derivative, a catechin complex, or a chloroquine derivative), the artesunate derivative or chloroquine derivative has an artesunate resistant mouse or chloroquine resistant It proved to be effective as a drug for mice.

Moreover, what was found out from the experimental results shown in Table 10 described above is that artesunate and catechin, or chloroquine and catechin are condensed by a condensation reaction, but artesunate and catechin, or chloroquine and catechin are The experimental results shown in Table 10 have revealed that the effect of the artesunate derivative or chloroquine derivative having a condensation bond by a condensation reaction as an agent is able to avoid resistant malaria parasites.

Furthermore, what was found from the experimental results described above and shown in Table 10 was that a drug combining catechin and chloroquine was found to be effective as a drug against chloroquine-resistant mice. However, it has a very important meaning for the following reasons (1), (2), (3), (4), and (5).

The reason for (1) is that chloroquine, which was developed as a drug with the name of the disease, is very inexpensive, although it has some side effects.

The reason for (2) is that the name of the disease is malaria, and 37 countries in the sub-Saharan Africa region have the highest number of malaria patients on the earth. This sub-Saharan region is also the poorest in the world. For this reason, expensive drugs cannot be used as therapeutic drugs.

The reason for (3) is that, as a therapeutic means for treating malaria with a disease name, it is a therapeutic means by oral administration using tablets that are simpler and cheaper than intravenous administration using a syringe or intraperitoneal administration. When treating malaria, the most inexpensive and optimal tablet for the purpose of oral administration is a chloroquine derivative formed by condensation reaction of chloroquine and catechin as the main raw material. .

The reason for (4) is that when catechin is administered orally in combination with chloroquine, catechin undergoes a condensation reaction when catechin and chloroquine are used in combination because catechin is easily decomposed in the small intestine of the digestive tract. Catechin is broken down in the digestive tract by forming drugs such as caffeine, tannin, iron, proteins, sugar chains, fats, or fatty acids that are easy to mix into catechin and chloroquine. It will be absorbed smoothly in the intestinal tract. In particular, since the chemical structure of catechin is chemically unstable, a fatty acid using an enzyme lipase for catechin is used for the purpose of condensing a fatty acid to catechin for the purpose of obtaining a chemically stable chemical structure. A catechin derivative or a catechin derivative (hereinafter abbreviated as catechin derivative) by synthesizing a new catechin compound by introducing a fatty acid into the catechin using an enzyme lipase. Is not decomposed in the intestinal tract of the digestive tract, the catechin derivative has a chemically stable chemical structure, and the catechin derivative has a chemical structure that is absorbed into the blood in the intestinal tract.
V), hepatitis C virus (HCV), adult leukemia virus (HTLV-1), papilloma virus (HPV)
Of oral drugs that can be administered orally as therapeutic means for the purpose of treating diseases caused by viruses such as herpes virus and influenza virus, or catechin derivatives directly intraperitoneally It has become possible to develop a pharmaceutical product for administration, a pharmaceutical product for direct intravenous administration of a catechin derivative, or a pharmaceutical product for the purpose of intravenous injection of catechin.

As for the reason of (5), in the case of treating infectious diseases caused by viruses such as AIDS, hepatitis C, adult leukemia, and influenza as well as the contents explained in (4) above. Rather than oral administration of catechin alone, drugs such as catechin mixed with caffeine, catechin mixed with tannin, catechin mixed with iron, or catechin mixed with fatty acid Thus, catechin is absorbed smoothly in the intestinal tract without being decomposed in the digestive tract.

Furthermore, it is a substance secreted by microorganisms, which is resistant to bacteria, resistant gonorrhea, or resistant virus (hereinafter abbreviated as resistant bacteria) against antibiotics that kill and kill the pathogenic microorganisms. As a result, a number of various excellent antibiotics that have been developed in the past are no longer effective as drugs. For example, penicillin, which was first discovered as an antibiotic and made from a solution obtained by culturing a kind of green mold, was a specific medicine for purulent diseases and pneumonia. Streptomycin, a kind of antibiotic, was a specific medicine for tuberculosis and pneumonia. However, about half a century after the discovery of penicillin or streptomycin, antibiotics such as penicillin or streptomycin have been produced by resistant bacteria. Is currently not used. As means for resuscitating antibiotics in which resistant bacteria such as penicillin or streptomycin (hereinafter abbreviated as penicillin) have emerged, penicillin and 11 types of catechins (hereinafter abbreviated as catechins) shown in Table 8 are used. And penicillin and catechin undergo a condensation reaction, and penicillin and catechin undergo a condensation bond, thereby penicillin derivatives that are chemical structures having a complex chemical structure, or Penicillin complex, catechin derivative, catechin complex (
(Hereinafter referred to as penicillin derivatives or catechin derivatives for short), all various antibiotics such as penicillin or streptomycin cause a catechin condensation reaction to form a condensation bond. Antibiotics can be changed to the chemical structure of antibiotics with a new chemical structure, so various antibiotics such as conventional penicillin or streptomycin are no longer effective due to the production of resistant bacteria It is an antibiotic that has a complex chemical structure, such as penicillin and catechin, or streptomycin and catechin by a condensation reaction to cause a condensation bond, and the chemical structure of various antibiotics such as conventional penicillin or streptomycin. Chemical structure completely different from conventional penicillin or streptomycin Different new penicillin, or new streptomycin (hereinafter, abbreviated, pseudo penicillin, or a pseudo-streptomycin) and by comprising,
Effective as a drug that kills resistant bacteria by avoiding bacteria resistant to various antibiotics such as conventional penicillin or streptomycin. The experimental results in Table 10 show that the use of pseudo-penicillin or pseudo-streptomycin allowed to produce a medicinal effect similar to that of conventional penicillin or conventional streptomycin results in a medicinal effect. Yes.

In addition, we report the results of drinking the alkaline extract of rooibos tea extracted from rooibos tea for 2 years. Application number filed by Yoshiaki Nagaura, the inventor of the present invention, details of contents described from (1745) on page 225 to (1778) on page 242 described in Japanese Patent Application No. 2007-252588 The book is again described below, but in 1817, British doctor James Parkinson, by drinking an alkaline extract of rooibos tea extracted from rooibos tea, extracted shaking paralysis (shaking p
alsy), tremor at rest, rigidity, slow movement (bradykines)
ia), postural reflex disorder (postural
disability), gait disturbance (gait
Extraction of rooibos tea to patients with (Parkinson's disease) as the main symptom (Parkinson's disease group) and (Parkinsonism) disease condition (hereinafter referred to as (Parkinson's disease)) Rooibos tea alkaline extract, for example, rooibos tea and sodium bicarbonate (NaHCO3) with 4.0g rooibos tea and 0.6g sodium bicarbonate (NaHCO3) for tea serving inside the tea bag Form a tea bag mixed together, put a tea bag with rooibos tea and sodium bicarbonate (NaHCO3) together in a tea cup containing about 200 ml of hot water, and make the rooibos tea have a PH concentration Living with a wheelchair, an alkaline extract of rooibos tea extracted with hot water, which is an alkaline aqueous solution of about 8.5 (Parki) nson's) patient is living in a wheelchair that can not stand and walk after taking 200ml of 3 times a day for about 3 months (Park
The condition recovered until the patient with inson disease could stand and walk. From the results of the experiment described above in which a patient with (Parkinson's disease) was drunk with an alkaline extract of rooibos tea extracted with rooibos tea, (1), (2), (3), ( The experimental results such as 4), (5), (6), (7) and (8) can be proved.

As a proof of the experimental result of (1), the graph (3) shown below is to Dr. Fumihiro Taguchi of the National Institute of Infectious Diseases Virus Part 3 in 4-7-1, Musashimurayama City Gakuen, Tokyo. , Mouse
It is the experimental result which experimented whether it was active with respect to the hepatitis virus of the rooibos tea which carried out the alkali extraction using the rat hepatitis virus which infects. This experimental result shows that the alkaline extract of rooibos tea that has been subjected to alkali extraction does not suppress the antiviral effect to 1/100, but the alkaline extract of rooibos has an antiviral effect. This is shown in the experimental result of graph (3).

The proof of the experimental result of (2) is that the anti-viral effect of uronic acid is due to the presence of a high concentration of acidic polysaccharides containing uronic acid in the alkaline extract of rooibos tea. You may judge that there is. This acidic polysaccharide containing uronic acid has been shown to exhibit antiviral effects such as anti-HIV effects.

As a proof of the experimental result of (3), the mechanism of why the disease whose name is (Parkinson's disease) develops has not been elucidated. Judging from the above experimental results and the experimental results of the following graph (3), it can be seen that the alkaline extract of Rooibos has an antiviral effect in the experimental results shown in the graph (3) below. Has been proved.
It is possible to judge from this, as a causal factor of the mechanism by which the disease name develops (Parkinson's disease), it is said that a certain kind of virus is mediated to develop (Parkinson's disease) Although it has not been identified, it may be judged that a certain type of virus is intervening, but the fact that it can be judged from the situation described above is that of intractable disease of unknown cause (Parkinson Disease) can be determined to be caused by a certain type of virus.

The proof of the experimental result in (4) is different from the content explained in (3) above, (Parkinso
As a cause of the effect of improving n disease), trace metal minerals contained in rooibos tea shown in the analysis table of the extract from rooibos tea shown in Table 11 below (Pa
It may be said that it may be effective in improving (rkinson's disease).

As proof of the experimental result of (5), unlike the contents explained in (3) and (4) above,
As a cause of the effect of improving (Parkinson's disease), although the analysis table of the extract from Rooibos shown in Table 11 above is not described as analysis data, the extract from Rooibos Catechin may be contained. However, since catechin is highly reactive, it has a condensation bond with tannin and iron due to a condensation reaction.
Since there is a possibility that the extract from rooibos tea does not contain catechin, it may be analytical data as shown in Table 11. But in reality, catechins may exist inside the extract from rooibos tea,
This suggests that catechins are also involved in rooibos tea's antioxidant and scavenge action (removal / removal of active oxygen).

As proof of the experimental result of (6), in the experimental result shown in the graph (3) below, the hepatitis virus of the mouse infected by the mouse is converted into an alkaline extract of rooibos tea extracted from rooibos tea. The experimental results in graph (3) show that mice inactivated the infecting hepatitis virus. From this, hepatitis A, B,
In addition, as an remedy for hepatitis C (hereinafter, abbreviated as hepatitis C), an alkaline extract of rooibos tea obtained by alkali extraction from rooibos has been shown to be a remedy for hepatitis C. In addition, adult leukemia virus, papillomavirus, rotavirus, norovirus, influenza virus, herpes virus, and AIDS virus (hereinafter abbreviated,
The following graphs show that the alkaline extract of rooibos tea extracted from rooibos has a medicinal effect as a treatment for patients with AIDS virus as a treatment for patients infected with AIDS virus. The experimental results of 1) are shown.

As a proof of the experimental result of (7), for alkali extraction from rooibos tea, for example, 4.0g rooibos tea and sodium bicarbonate (NaHCo3) for tea servings inside the tea bag Form a tea bag with 0.6g together,
Or a mug (hereinafter abbreviated as a mug) with 200 ml of hot water in the mug, 4.0 g of rooibos tea and 0.6% of sodium bicarbonate (NaHCo3)
It was found that the most convenient drinking method is to put the tea bag with g in a mug containing 200 ml of hot water and extract it with alkali extraction from rooibos tea.

As a proof of the experimental result of (8), as described in (1) to (5) above, a rooibos tea extracted from rooibos tea in a patient whose disease name is currently unknown (Parkinson disease) as an intractable disease When a patient with (Parkinson's disease) drinks an alkaline extract for several months, for example for a period of 2 to 3 months, a patient with a wheelchair (Parkinson's disease) can stand and walk If it is determined that the cause of the onset of (Parkinson's disease) is the trigger of the onset of the virus, it is described in Table 8 described above 11
Single item catechin purified to 98% or more, or polyphenone 70S or sunphenon BG
-3, or other catechins (Parkinson's disease) by oral administration, intraperitoneal administration, or intravenous administration, the name of the disease whose cause is currently unknown (Pa
Rkinson's disease) can be determined from the results of an experiment in which an alkaline extract of rooibos tea extracted from rooibos tea was also taken from a patient with Parkinson's disease. It is a result.

In addition, graph (3) shown below shows a mouse infected with a mouse by Dr. Fumihiro Taguchi of the National Institute of Infectious Diseases Virus Part 3 in 4-7-1, Musashimurayama City Gakuen, Tokyo. The results of experiments on whether or not octagonally ground fine powder, rooibos tea, Tochu tea, and chlorella have or are not active against murine hepatitis virus using is there.

Main user Sender: “Fumihiro Taguchi” (ftaguchi@nih.go.jp)
To: (sikasyo@deluxe.ocn.ne.jp)
Date sent: 12 June 2006 12:45
Attachment: Octagon.ppt
Subject: Octagon

Further, the graph (3) of the experimental results described above will be described as the graph (3) and FIG. 3 below. FIG. 3 shows a finely crushed octagon inside the tea bag. 7.0 powder
g, rooibos tea 4.0g, Tochu tea 4.0g, and chlorella 4.0g, 4 different types of tea bags were created, each with 4 types of different tea bags 0.6
Make 4 types of tea bags each containing g sodium bicarbonate (NaHCO3), about 200ml
In each of the four teacups (mugs) containing hot water, the individual teacups were put into individual teacups, and the PH concentration of the boiled hot water inside the teacup was made alkaline with 8.5 or more. Leave the tea bag in the tea cup for about an hour and leave it in an aqueous solution containing 4 different types of active ingredients. The experimental results on the activity of hepatitis virus in mice that are used to infect mice are shown in FIG.

In addition, Control shown in FIG. 3 creates a tea bag in which only 4.0 g of rooibos tea is put in the tea bag and no sodium hydrogen carbonate (NaHCO 3) is added.
Using hot water in a tea cup containing approximately 200 ml of hot water boiled in almost neutral tap water from Musashimurayama, Tokyo, with a pH of around 7.0. The aqueous solution containing the active ingredient of rooibos tea extracted is used as Control.

In addition, the active ingredients obtained by alkaline extraction from the four types of octagon, rooibos tea, Tochu tea, and chlorella shown in FIG. Compared with Control extracted from rooibos tea, it is an active ingredient that has been alkali extracted from 3 types of octagon, tochu tea, and chlorella, which were also alkali extracted, other than rooibos, which was alkali extracted in the alkali extracted fraction The graph (1) shows that the experimental result of not being able to inactivate the hepatitis virus of a mouse infected with a mouse is shown in FIG.

Now, in conclusion, the experimental results shown in Fig. 3 show that with the tea bag using a tea bag with 4.0g rooibos tea and 0.6g sodium bicarbonate (NaHCO3) inside the tea bag, The aqueous solution containing the active ingredient of rooibos tea, which was alkali-extracted in the alkaline extraction fraction using a tea bag containing sodium bicarbonate (NaHCO3), was controlled at 106 (300 104 (around 10 million) murine hepatitis viruses (40,600)
Although it was possible to inactivate and reduce the number of digits of about 2 digits (around 0), exactly 1
Fig. 3 shows the results of an experiment that succeeded in inactivating the rat hepatitis virus that was not inactivated up to 1/100 but was infected to about 1/65.

In addition, the murine hepatitis virus, which is used in the experimental results shown in Fig. 3, to infect the mouse, the coronavirus, is classified as a coronavirus mate, and the highly virulent highly pathogenic avian influenza (H5N1) ) And the same coronavirus, the experimental results shown in Fig. 3 show that the human body is infected, including the hepatitis C virus that infects the human body, highly virulent highly pathogenic avian influenza ( FIG. 3 also shows experimental results demonstrating that it can be used as a means of treating infections caused by coronaviruses such as H5N1), hepatitis A, hepatitis B, and hepatitis C.

In addition, retroviruses such as herpes virus, HIV virus, adult T cell leukemia virus, papilloma virus, Ebola hemorrhagic fever virus, and rotavirus that have a similar structure to that of coronavirus, and similar to retrovirus The structure is also the same as a coronavirus because there is a nucleic acid in the center, and the structure is a virus with a structure in which the outer periphery of the nucleic acid is protected by the envelope that is the epidermis, with the central nucleic acid as the center. Because it is a virus of structure, make a tea bag containing about 2.0g, 3.0g, or 4.0g of rooibos tea and about 0.6g of sodium bicarbonate (NaHCO3), boil around 200ml Fig. 3 shows the active ingredients extracted from rooibos tea in the alkaline extraction fraction in the tea cup containing hot water. As with the experimental results shown, it is possible to inactivate herpes virus, HIV virus, adult T cell leukemia virus, Ebola hemorrhagic fever virus, and rotavirus, so HIV virus and rotavirus listed above respectively The experimental results in Fig. 3 show that it can be used to treat infections caused by the above.

Further, for example, the alkaline substance put together with the rooibos tea in the tea bag described above is sodium bicarbonate, and the alkaline substance other than calcium hydroxide is sodium carbonate, potassium hydroxide, water. An alkaline substance such as sodium oxide and ammonium hydroxide may be placed inside the tea bag, and any one of the alkaline substances may be put together with the rooibos tea.

In addition, what was found from the experimental results of the experiment shown in FIG. 3 is that, for example, the inside of the tea bag is 2.0 g, or 3.0 g, or 4.0 g, or 8.0 g, or 10.0 g, or 12.0 g. Amount of sodium bicarbonate (NaHCO3) 0.1g or more, or 0.2g or more, or 0.3g or more, or
0.4 g or more, or 0.5 g or more, or 0.6 g or more, or 0.7 g or more, or 0.8 or more, or 0.9 g or more,
Alternatively, add a tea bag containing 1.0 g or more, 2.0 g or more, or 3.0 g or more of sodium bicarbonate (NaHCO3) together with rooibos tea to the inside of the tea bag. Put the tea cup inside the tea cup, the pH of the hot water inside the tea cup is weakly alkaline 7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8 or higher, or 8.0 or higher, or 8.5 or higher, or 9.0 or higher, or 9.5 or more, 10.0 or more, or 11.0 or more using hot water made alkaline, the aqueous solution obtained by alkaline extraction of the active ingredient contained in the rooibos tea in the alkali extraction fraction from rooibos tea is described above. It is also effective when used as a therapeutic tool for patients with hepatitis C, AIDS, or rotavirus.
The experimental result shown in 3 is also the experimental result of the experiment that was proved indirectly.

In addition, for example, by using a container such as a kettle or a pan, the effective component contained in the rooibos tea is extracted from the rooibos tea in the alkaline extraction fraction, and the rooibos tea contains When making plenty of aqueous solution containing ingredients, for example,
About 10 g of rooibos tea and 2.0 g of sodium bicarbonate (NaHCO3) inside the tea bag
Make a tea bag with the front and back together, for example, add 1.0 to 2 water to the kettle,
Inside the kettle containing water, 10 g of rooibos tea and sodium bicarbonate (NaHCO3) 2.0
Put one, two, or three tea bags with g in the aqueous solution inside the kettle, and put the PH concentration of the aqueous solution inside the kettle inside the tea bag. Sodium bicarbonate (NaHCO3) is dissolved inside the kettle, and the PH concentration of the aqueous solution inside the kettle is an alkaline aqueous solution. The PH concentration is 7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8. A tea bag using an alkaline aqueous solution inside the kettle, or more than 8.0, or 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more Boil the rooibos tea that is put in the inside and boil it for about 10 minutes.
After leaving the tea bag inside the kettle and letting it cool, after extracting the tea bag from the inside of the kettle, the alkali extraction from the rooibos tea with the alkali extraction fraction, Alkaline extraction can be easily performed from rooibos tea very easily.

In the case of draining water, as described above, for example, a tea bag containing about 10 g of rooibos tea and about 2.0 g of sodium hydrogen carbonate (NaHCO3) inside the tea bag, or When 2 or 3 bags are placed inside a container containing about 800 ml of aqueous solution and cooled in a refrigerator, the pH of the aqueous solution inside the container is adjusted to the sodium bicarbonate ( NaHCO3) is dissolved in the aqueous solution inside the container, so that the PH concentration of the aqueous solution inside the container is an alkaline aqueous solution, the PH concentration is 7.2 or more, 7.4 or more, or 7.
6 or more, or 7.8 or more, or 8.0 or more, 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0
Above, or 10.5 or more, or 11.0 or more alkaline aqueous solution, using an alkaline aqueous solution inside the container, from the rooibos tea that is put in the tea bag, in the alkaline extraction fraction in the refrigerator The active ingredient contained in the rooibos tea can be alkali extracted very easily.

Furthermore, for example, a fine powder such as rooibos tea, grassroots bark or herbal medicine (hereinafter abbreviated as rooibos tea) and an alkaline substance are put together in the tea bag, Alkaline substances used for alkali extraction from the rooibos tea contained in the alkali extraction fraction include sodium carbonate, sodium bicarbonate, potassium hydroxide, sodium hydroxide, and ammonium hydroxide. One type of tea can be put inside the tea bag, or two or more alkaline substances can be put inside the tea bag together with rooibos tea, for example, sodium carbonate with rooibos tea as an alkaline substance. Place the tea bag in the inside of cold water that is an aqueous solution or boiling hot water. The sodium carbonate in the bag is cold water,
Or dissolve it in boiling hot water, and adjust the PH concentration of cold water or boiling hot water.
7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8 or higher, or 8.0 or higher, or 8.5 or higher, or 9.
0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more or 12
Uses cold water or boiling hot water, which is an alkaline aqueous solution of 0.0 or more, to convert the active ingredients contained in rooibos tea into the alkaline extract fraction from rooibos tea contained in the tea bag. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, And its manufacturing method.

Further, a fine powder (hereinafter abbreviated as instant rooibos tea) obtained by drying an aqueous solution extracted using boiling water in which rooibos is boiled by a drying means such as spray drying or freeze drying, for example, Create a stick with an instant rooibos tea and, for example, sodium carbonate, which is an alkaline substance, inside the stick when putting it in a small bag (hereinafter abbreviated as a stick), for example, a tea cup Cold water, which is an aqueous solution contained in the inside of the water, or sodium carbonate contained with the instant rooibos tea contained in the stick inside the boiling hot water, for example, cold water inside the tea cup Or using cold water or hot water with a PH concentration of hot water of 7.5 or higher, or 8.0 or higher. A food raw material characterized in that cold water obtained by alkaline extraction of an active ingredient contained in instant rooibos tea from rooibos tea in an alkali extract fraction, or hot water as drinking water, or other food products, Food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

Furthermore, rooibos tea and, for example, sodium carbonate, which is an alkaline substance, are put together in boiling hot water, and sodium carbonate is dissolved in boiling hot water. Using an alkaline boiling hot water of 8.5 or more, the active ingredient containing rooibos tea was alkali extracted with an alkali extraction fraction, and an aqueous solution containing the rooibos tea active ingredient, A fine powder (hereinafter abbreviated as "alkaline instant rooibos") that has been alkali extracted from rooibos tea that has been dried using spray drying or drying means such as freeze-drying and changed to alkaline properties. For example, an alkaline instant rooibos tea in a small bag (hereinafter abbreviated as a stick) For example, use cold water or hot water in a container such as a tea cup to dissolve alkali roasted instant rooibos tea, or use hot water as drinking water, or make other food products. Characteristic food raw material, food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof

Also, inside the boiling hot water, rooibos tea and alkaline substance sodium carbonate, or sodium bicarbonate, or potassium hydroxide, sodium hydroxide, ammonium hydroxide, or ammonia water (hereinafter abbreviated, (Sodium carbonate) is put into the boiling hot water together, the active ingredients contained in the rooibos tea, the PH concentration of the boiling hot water, the alkaline substance sodium carbonate dissolved Let the PH concentration
7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8 or higher, or 8.0 or higher, or 8.5 or higher, or 9.
0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more or 12
Boiling hot water, which is an aqueous solution having an alkalinity of 0.0 or more, or boiled hot water obtained by alkali-extracting an active ingredient contained in rooibos tea in an alkaline extraction fraction using cooled cold water, Or Tetre which is a container made of plastic bottle or paper with cooled cold water
It is characterized by being placed in a container such as Pak and distributed for drinking as drinking water, or an alkaline carbonated drinking water containing carbon dioxide gas using a plastic bottle, or other food products. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

Furthermore, using an alkaline substance such as rooibos and sodium carbonate, or sodium bicarbonate, for example, PH concentration is 7.2 or more, or 7.4 or more, or 7.6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more, Or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more, or 12.0 or more using cold water or boiled hot water to perform alkaline extraction with an alkaline extraction fraction Use an aqueous solution containing the active ingredient of rooibos tea, or spray-drying or freeze-drying an aqueous solution obtained by alkaline extraction of the active ingredient contained in rooibos tea in the alkaline extraction fraction Examples of the method of using the fine powder obtained by using a drying means include hepatitis A, hepatitis B,
Or an envelope that is an epidermis such as hepatitis C, or other similar shaped hepatitis virus, papilloma virus, saas virus, influenza virus, rotavirus, herpes virus, and HIV virus, or retrovirus, Since it is particularly effective for viruses in the shape of viruses around the nucleic acid centered on nucleic acids, it can be used as a food raw material or food additive with antiviral effect, or all various miscellaneous foods, frozen desserts, beverages As an additive of water and alcoholic beverage water, or can be the main raw material, for example, bread such as bread, confectionery additives, or as additives such as rice cakes, donuts, cakes, Japanese confectionery, Or as an additive for noodles such as udon, ramen, spaghetti, macaroni, or As an additive for cooked rice such as rice balls and lunch boxes, or as an additive such as popsicle, ice cream, blow ice and stick ice, or as a raw material, as an additive for drinking water, or as a raw material, or as shochu, sake, vodka By making it an additive for alcoholic beverages such as whiskey, or as the main raw material,
Anti-viral active ingredients that have been alkali extracted from rooibos tea in the alkaline extract fraction are easily ingested by the human body to prevent viruses at the cellular level so that the human body can combat various kinds of viruses. Food ingredients, foods characterized by the ability to activate and the growth of active cells that can enhance the immunity of the human body and resist viruses
Health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, the PH concentration of boiled hot water, boiled hot water, cold water, or a low-temperature aqueous solution (hereinafter abbreviated as cold water) at room temperature or lower is set to, for example, sodium carbonate (Na2CO3) or sodium hydrogen carbonate. Using an alkaline substance such as (NaHCO 3), for example, alkaline cold water having a PH concentration of cold water of 7.2 or higher, or 7.5 or higher, or 8.0 or higher, or 8.5 or higher, or 9.0 or higher, or 9.5 or higher, or 10.0 or higher For example, rooibos = commonly called red shrub branches, trunks, roots, leaves, etc., fine powder of grass root bark, or herbal medicine made of fine powder, or rooibos tea made of fine powder (Hereinafter, abbreviated as "Rooibosty"), an active ingredient contained in Rooibos tea, an aqueous solution obtained by alkaline extraction from rooibos tea in an alkaline extraction fraction in cold water at room temperature or lower, Used as a treatment for hepatitis A, or hepatitis B, or hepatitis C, or other similar forms of hepatitis virus, or other AIDS patients who develop other infectious disease-causing viruses, or contains rooibos tea As a means of concentrating acidic polysaccharides such as uronic acid, neutral sugar, or reducing sugar with ultra-high concentration, for example, alkaline extraction from rooibos in cold water at room temperature or in boiling hot water The aqueous solution extracted with alkali in the fraction is dried by a drying means such as spray-drying or freeze-drying, and the fine powder in which the active ingredient of rooibos tea is concentrated to a very high concentration is the cause of hepatitis virus or other intractable diseases. When used as a means of treatment for AIDS patients who develop virus, etc., uronic acid, neutral sugar, or alkali extracted from rooibos tea in an alkaline extraction fraction, or Spikes that exist on the surface of envelopes that are epidermis of coronaviruses such as hepatitis virus, herpes virus, rotavirus, sirth virus, influenza virus, papilloma virus, and HIV virus, or retroviruses. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tee packs, characterized by inactivating various miscellaneous viruses and treating many intractable diseases Raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

In addition, rooibos tea from sodium carbonate (Na2CO3), or sodium bicarbonate (NaHCO
3) Using an alkaline substance such as cold water, which is an aqueous solution with a PH concentration of 8.5 or higher, or an active ingredient contained in rooibos tea in an alkaline extraction fraction at a low temperature below room temperature. When performing alkali extraction, spend several days on the date and time, soak rooibos in cold or low-temperature aqueous solution, and extract the active ingredients contained in rooibos in the alkaline extraction fraction. Food raw materials characterized by extracting, food, health food, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials,
Tee-pack raw materials, tee packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

In addition, uronic acid obtained by alkali extraction from rooibos tea, mangrove, or eleven types of catechins shown in Table 8 (hereinafter abbreviated as rooibos tea or catechin) in an alkali extraction fraction The reason why acidic polysaccharides such as neutral sugars and reducing sugars inactivate coronaviruses or retroviruses is that the acceptor of key proteins present on the surface of the virus is inactivated, so human cells Since the properties or characteristics of the keyhole protein receptor on the surface of the virus will not match, the virus will not be able to adsorb to the receptor present on the cell surface using the acceptor present on the surface of the virus. . Normally, if the acceptor present on the surface of the virus matches the nature or characteristics of the receptor present on the surface of a human cell, the virus will only enter the inside of the cell, and the viral gene When entering with the wrapped bag attached
There are two ways of intrusion. The problem is that an active ingredient obtained by alkali extraction from rooibos tea or 11 kinds of active ingredients shown in (Table 8) are variously inactivated by acceptors existing on the surface of the virus. Regardless of the type of virus, the virus can attach to a receptor present on the surface of the cell, adsorb to the cell and block it from entering the cell, and the virus can enter the cell. Since it has the greatest feature in inactivating the virus without being able to do it, the first effect is, for example, H in the human body
Even if the IV virus invades, the HIV virus cannot enter the inside of the human cell using an acceptor, so the viral gene results in a block of synthesis and proliferation. Or, the active ingredients contained in 11 types of catechins shown in (Table 8), for example, block and protect on the surface of cells even if HIV virus enters the human body. Therefore, the first effect is that there is a preventive effect that does not become an AIDS patient, and the second effect is that the virus is blocked and protected on the surface of the cell, so it is resistant strain like other drugs The second effect is the advantage that the emergence of HIV virus and so on does not occur.
As the third effect, the third effect is that there are no side effects. Rooibos tea or (
Inactivate the acceptors on the surface of the virus using active ingredients such as acidic polysaccharides that are obtained by alkaline extraction of the active ingredients contained in the 11 types of catechins shown in Table 8) in the alkaline extraction fraction. Food ingredients, foods, health foods, drinking water, drinking water ingredients, alcoholic drinking water, shochu ingredients, tay pack ingredients, which block and defend against adsorption on the surface of human cells Tee-pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

Furthermore, inside the boiling hot water, rooibos tea and alkaline substances such as sodium carbonate, sodium bicarbonate, potassium hydroxide, sodium hydroxide, ammonium hydroxide, or ammonia water (hereinafter abbreviated). , Sodium carbonate) into the boiling hot water together, the active ingredients contained in the rooibos tea, the PH concentration of the boiling hot water, the alkaline substance sodium carbonate Dissolve PH
Concentration is 7.2 or more, or 7.4 or more, or 7.6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more,
Or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more, or 12.0 or more alkaline aqueous solution, boiling hot water or cooled cold water Rooibos using boiling hot water obtained by alkaline extraction of the active ingredient contained in the alkaline extraction fraction or cooled cold water, for example, an alkaline boiling aqueous solution having a PH concentration of 8.5 or more PH concentration of aqueous solution obtained by alkali extraction of active ingredients contained in tea, weak alkalinity with a PH concentration of 7.4 or less that is gentle to the human body, or P
In order to obtain an acidic PH concentration with an H concentration of 7.0 or less, acidic substances such as hydrochloric acid (HCI), groundwater, or other aqueous solutions were used to make the pH concentration acidic or slightly alkaline drinking water. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and methods for producing the same.

In addition, to extract active ingredients such as uronic acid, neutral sugar, or reducing sugar contained in rooibos tea, mangrove or pine nut shell (hereinafter abbreviated as rooibos tea) In the inside of a boiling aqueous solution having an alkaline substance such as sodium carbonate or sodium hydrogen carbonate and having a PH concentration of 8.0 or more and within 12.0, for example, effective in containing rooibos tea Alkaline aqueous solution that has been alkali extracted from rooibos tea with a PH concentration of 8.0 or more and within 12.0 from rooibos tea has been rotted because various bacteria are less prone to grow than alkaline aqueous solution. In order to obtain an acidic aqueous solution with a pH of 3.0 or more and 7.4 or less, or a weakly alkaline aqueous solution with a PH concentration of 7.4 or less, hydrochloric acid (HCI) or Is an aqueous solution such as other acidic substances or ground water or natural water, and the alkaline aqueous solution is diluted to become an acidic aqueous solution, and the PH concentration is weakly alkaline with a pH of 7.4 or less, or the PH concentration is 7.0. By using the following acidic drinking water, it can be stored for a long period of time, it is difficult for bacteria to propagate, and it is difficult to rot, when extracting an active ingredient contained in rooibos tea, the PH concentration is, for example, 8.0 or higher to 12.0
When an active ingredient contained in rooibos tea is extracted by alkali extraction using an alkaline aqueous solution within 5% and filled into a container such as a plastic bottle, for example, P
Food raw materials, foods, health foods, drinking water, drinking water raw materials characterized by being weak alkaline aqueous solutions with H concentration of 7.4 or less, or acidic drinking water with PH concentration of 3.0 or more and 7.0 or less, Alcohol drinking water, shochu ingredients, tay pack ingredients, tay packs, feed ingredients,
Pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

Furthermore, using an active ingredient contained in rooibos tea, or mangrove, or pine nut shell (hereinafter abbreviated as rooibos tea), HIV virus for AIDS patients, or HBV virus for hepatitis patients, Or to extract an antiviral effect substance from Rooibos, which can inactivate viruses such as HCV virus of hepatitis patients, influenza virus such as H5N1 or Thurs virus, etc. From 12.0
Of uronic acid, neutral sugar, or reducing sugar, etc., which has a high anti-viral effect unless the alkaline extraction is carried out using a boiling aqueous solution having a high alkaline PH concentration as much as possible. It is not possible to effectively extract a large amount of acidic polysaccharides from rooibos tea, which is used for alkaline extraction from rooibos tea. It is inappropriate to directly make drinking water for alkaline aqueous solution with antiviral effect, because it is strongly alkaline aqueous solution with PH concentration of 8.0 or more and within 12.0, so it is not suitable for drinking water directly. Use hydrochloric acid (HCI), or other acidic substances, or ground water, natural water, or other aqueous solutions to adjust the pH concentration to 3.0.
It is characterized by diluting the PH concentration to a human-friendly PH concentration of 7.4 or less from the above, and using an aqueous solution containing an antiviral effect substance contained in Rooibos tea as a human-friendly drinking water Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

The National Institute of Infectious Diseases virus, 4-7-1, Musashimurayama City Gakuen, Tokyo, uses an aqueous solution in which rooibos tea is placed in a boiling aqueous solution with a pH of 8.5 and extracted with alkali. The result of the experiment conducted by Prof. Fumihiro Taguchi in Part 3 is shown in graph (1). The type of virus used in this experiment is the hepatitis virus of a coronavirus that is infected by mice. The control result shown in this graph (1) is shown in graph (1).
Shows the experimental results of inactivating the hepatitis virus infecting mice using an aqueous solution extracted from rooibos tea using a neutral, boiling aqueous solution with a pH of 7.0. ) Rooibosti in the bar graph shows the neutral boiling, which is the experimental result of inactivating the hepatitis virus that infects mice using an alkaline aqueous solution in which an aqueous solution with a pH of 8.5 is boiled. Experimental results using aqueous solution and pH concentration of 8.
5 and aqueous solutions using an aqueous solution are boiled, the experimental results in which the alkaline extraction from rooibos and Control of experimental results, when comparing the two experiments, Control is to the number of viruses is of ¹⁰⁶ digits On the other hand, using an alkaline aqueous solution with a PH concentration of 8.5, an alkaline extract was obtained from rooibos tea. The active ingredient contained in rooibos tea was extracted from an aqueous solution using an alkaline aqueous solution. effect of inactivation, the number of viruses are shown bar graph (1) the experimental results are reduced to the 10 ⁴ digits, the number of virus to 10 ⁴ digits from 10 ⁶ digits, approximately The result of an experiment in which a two-digit number of viruses has decreased,
The results of the experiment shown in Table 8 and the octagon, Tochu tea, and chlorella shown in graph (1) are also boiling in an aqueous solution with a PH concentration of 8.5, just like the Rooibos tea. It is an experimental result using an aqueous solution extracted from an octagon, Tochu tea, and chlorella using an alkaline aqueous solution using an aqueous solution,
It is an experimental result that neither Tochucha nor Chlorella was able to inactivate the virus. So, why does the aqueous solution extracted only from rooibos tea have the effect of inactivating the virus? At present, about 30,000 types of viruses have been discovered. Different types of viruses have been discovered, but the majority of viruses have a structure with epidermal proteins around the nucleic acid. The majority of the aqueous solution, which is more than 90%, extracted from rooibos tea, damages the key protein, which is an acceptor necessary when the virus is adsorbed to the host cell, and disables the key protein. In addition, the graph indicates that the virus can no longer be adsorbed to the host cell and can no longer function as a virus. The experimental result shown in 1) was an experimental result that could be judged to be shown. If the experimental result shown in (Table 8) is true, the cause is HIV virus. SARS patients who are AIDS patients, hepatitis patients caused by HBV virus, or HCV virus, influenza patients caused by viruses such as H5N1, herpes virus, or severe acute respiratory syndrome However, it can be judged that all other diseases caused by viruses that have a structure of a virus with a structure of epidermal protein around the nucleic acid, mainly from other nucleic acids, can be prevented and treated. By taking the active ingredient that was extracted from the rooibos tea, the virus explained above, the host cell For example, in the case of an AIDS patient, the discovery of the action and effect that prevents the virus from entering the host cell by adsorbing to the HIV cell A food raw material characterized by providing drinking water, which is an aqueous solution for use as a therapeutic means, which can be a therapeutic means that can be completely achieved from the body of a patient,
Food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, mangroves, or pine nut shells (hereinafter abbreviated as rooibos) are basically acidic substances with an acid value of 5.0 or less, and therefore have a neutral PH concentration. Even if an active ingredient contained in Rooibos tea is extracted using an aqueous solution of around 7.0, Rooibos tea is an acidic substance. Even if the active ingredients that are present are extracted, the aqueous solution will become acidic and PH
Concentration will be around 6.0. Therefore, an acidic aqueous solution with a PH concentration of around 6.0 is added to sodium carbonate (Na2CO3).
), Or using an alkaline substance such as sodium bicarbonate (NaHCO 3), and adjusting the PH concentration to 8.0.
From 12.0 or less to an alkaline aqueous solution, heated and boiled and boiled, as shown in Table 8, after the alkaline extraction of the antiviral effect active ingredients contained in Rooibos tea, Weakly alkaline with a pH of 7.4 or less using hydrochloric acid, other acidic substances, ground water, or natural water as an alkaline aqueous solution containing an active ingredient with antiviral effect extracted from rooibos. Or an acidic aqueous solution containing an active ingredient having a PH concentration of 7.0 or less, or PH
An acidic aqueous solution containing an active ingredient having a concentration of 6.0 or less, or an acidic aqueous solution containing an active ingredient having a PH concentration of 5.0 or less, or an acidic aqueous solution containing an active ingredient having a PH concentration of 4.0 or less Even if it is filled into a container such as a plastic bottle, which is an aqueous solution or an acidic aqueous solution containing an active ingredient having a PH concentration of 3.0 or less, which is an aqueous solution in which various bacteria are difficult to propagate, Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials characterized by providing acidic drinking water that has been made acidic for the purpose of preventing decay , Tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, mangrove, or pine nut shell (hereinafter abbreviated as rooibos tea) is placed inside the tea bag with an alkaline substance such as sodium carbonate (Na2CO3) or sodium bicarbonate (NaHCO3). When making a tea bag that is put inside the tea bag together with sodium carbonate (hereinafter abbreviated as sodium carbonate), the active ingredient contained in the rooibos tea is alkali extracted in the boiling aqueous solution. In the case where the active ingredient contained in rooibos tea is extracted with alkali in cold cold water, the tea bag is made by mixing rooibos tea and sodium carbonate together in the sealed container of the tea bag. The active ingredient and sodium carbonate contained in Rooibos tea inside the sealed container, high inside the tea bag which is a sealed container It will cause a chemical reaction as an alkaline aqueous solution of concentration, using sodium carbonate sealed inside the tea bag,
PH inside the tea bag that seals the active ingredients contained in Rooibos tea
Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, which are characterized by a chemical reaction in a more alkaline aqueous solution with a higher concentration to extract alkali from rooibos tea , Tay pack raw material, tay pack, feed raw material,
Pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

In addition, rooibos tea, or mangroves, pine nut shells, green tea, or black tea,
Or brown rice tea, oolong tea, puer tea, tea such as herbal tea, or coffee (hereinafter abbreviated as rooibos tea) erases and removes bad active oxygen generated in the human body. The redox potential is a measure that represents the activity of a substance to be oxidized. The larger the positive value, the stronger the oxidizing power, the larger the negative value, the stronger the reducing power, and the richer the amount of active hydrogen (negative ions). It is shown that. Paradoxically explaining that the substance that scavenges and removes active oxygen is generally called a scavenger, and that rooibos tea has a powerful scavenging action for removing active oxygen.
Rooibos has the ability to store hydrogen ions (hereinafter abbreviated as active hydrogen) in an aqueous solution, and contains active hydrogen having the property of becoming negative ions (active hydrogen content). The active hydrogen in the form of negative ions present in the aqueous solution in which the active ingredient contained in the rooibos tea is extracted by using rooibos, hot water or cold water, as a result, the active oxygen is eliminated, and It is removed and neutralized. For the purpose of further increasing the storage capacity of this rooibosty that stores negative hydrogen active hydrogen, for example, the rooibosty is placed inside a container filled with hydrogen gas, A tea bag that absorbs or contains rooibos tea
The inside of a container formed using a film through which hydrogen gas cannot pass is filled with a tea bag containing rooibos and hydrogen gas together to allow rooibos to absorb hydrogen gas or rooibos Put sodium bicarbonate (NaHCO3) or sodium carbonate or other alkaline substance (hereinafter abbreviated as sodium carbonate (Na2CO3)) and rooibos tea together in the tea bag containing tea, When sodium carbonate (Na2CO3), which is put together with rooibos tea in the tea bag, is separated in the aqueous solution by releasing sodium carbonate (Na2CO3), the amount of active hydrogen with high concentration of negative hydrogen ions I discovered that the concentration of (negative ions). For example, rooibos and sodium carbonate (Na2CO3) are used for an aqueous solution containing active hydrogen with an active hydrogen content (negative ion) with an oxidation-reduction potential of -100 or -200 or higher. Food ingredients, foods, health foods, drinking water, drinking water ingredients, alcoholic drinking water, shochu ingredients, tay pack ingredients, tay packs, feed ingredients, pharmaceutical ingredients, pharmaceuticals, alcohol ingredients, and Its manufacturing method.

In addition, a country that constantly drinks groundwater containing a large amount of scavenging active hydrogen, which eliminates and removes active oxygen generated in the human body, is famous for its longevity. The ground water that is the mineral water of this hunza kingdom,
Ultra-high concentration active hydrogen contained in groundwater in the Kingdom of Hunza, which contains active hydrogen with a redox potential of -100 to -200 or more, which is the unit of active hydrogen content (negative ions) However, by eliminating the occurrence of cancer and reducing the incidence of other diseases, the reason that the life expectancy of the people of the Hunza kingdom has become the world's longest life expectant 100 years old or more, an amazing longevity country It is said that the fact that drinking water is an aqueous solution containing abundant active hydrogen contained in the groundwater of the Kingdom of Hunza is closely related to long life with a long average life. Also, in Japan, for example, the analysis result of mineral water, which is the groundwater sold under the trade name Hita's Tenryo Water, shows that the redox potential is +80 to +190. The amount of active hydrogen (negative ions) contained in Hita's heavenly water is the mineral water with the highest concentration of active hydrogen (negative ions) among the mineral waters sold in Japan. Comparing Hita's Tenshu water and the ground water of the Hunza kingdom, the ground water, which is the mineral water of the Hunza kingdom, contains about 10 times as many active hydrogens as this high concentration of active hydrogen. Groundwater is responsible for the longevity of the Hunza kingdom. Moreover, even in the groundwater of the Kingdom of Hunza, the amount of active hydrogen (negative ions) disappears from the aqueous solution in 2 to 3 days, so that it cannot be stored and transported for a long time. Therefore, anytime, anywhere drinking water containing active hydrogen that has a redox potential equivalent to the amount of active hydrogen (negative ions) similar to groundwater in the Kingdom of Hunza is easily equivalent to that of the Hunza Kingdom. As means for preparing drinking water containing, for example, rooibos tea, or mangrove, or pine nut shell, or green tea, or black tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea Sodium bicarbonate (NaHCO 3) inside a tea bag containing tea or coffee (hereinafter abbreviated as “Rooibos”)
), Or sodium carbonate (Na2CO3), or other alkaline substance (hereinafter abbreviated as sodium carbonate (Na2CO3)), for example, in a tea bag containing rooibos tea When alkaline extraction is performed using hot water or cold water boiled using a tea bag with sodium carbonate (Na2CO3) inside, the amount of active hydrogen (
Negative ion) is equivalent to the amount of active hydrogen (negative ions) in the ground water of the Hunza kingdom, which has an oxidation-reduction potential equivalent to -100 to -200 or more. It has been found that it is possible to make drinking water containing active hydrogen. In addition, the means for generating active hydrogen in an aqueous solution using a tea bag containing rooibos and sodium carbonate (Na2CO3) inside the tea bag can be stored anytime and anywhere, and changes over time. Drink water containing high concentration of active hydrogen without anytime, anywhere can be stored, and can provide high concentration of active hydrogen (negative ions) without change over time As in the case of the Hunza Kingdom, the concentration of active hydrogen (negative ions) under the conditions necessary to make the average lifespan 100 years or older is high, and the redox potential is negative -50, or Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials characterized by providing an aqueous solution as large as -100, -150, or -200 as drinking water , Tee pack, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and a manufacturing method thereof.

In addition, rooibos tea, or mangroves, pine nut shells, green tea, or black tea,
Or rooibos in tea bags or other containers containing brown rice tea, oolong tea, puer tea, or other herbal tea, or coffee (hereinafter abbreviated as rooibos tea) A tea bag containing sodium bicarbonate (NaHCO3), sodium carbonate (Na2CO3), or other alkaline substance (hereinafter abbreviated as sodium carbonate (Na2CO3)) inside a container containing tea. An activity that neutralizes and removes active oxygen generated in the human body by performing alkali extraction in a tea cup or other container containing boiling hot water or cold water Rooibos and charcoal containing hydrogen in a tea bag or other container containing rooibos and sodium carbonate (Na2CO3) A chemical reaction of sodium acid (Na2CO3), for example, generating active hydrogen in the boiling water or cold water where the active hydrogen content (negative ion) has an acidic reduction potential of -100 to -200 or more. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol Raw materials and manufacturing method thereof.

In addition, rooibos tea, or mangrove, pine nut shell, green tea, tea, brown rice tea, oolong tea, puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). Sodium carbonate (Na2CO3), or sodium bicarbonate (NaHCO3), or potassium hydroxide (KOH)
Or sodium hydroxide (NaOH) or ammonium hydroxide (NH4OH) or ammonia (NH3
), Or other alkaline substances (hereinafter abbreviated as sodium carbonate (Na2CO3)) together with rooibos tea in the tea bag and sodium carbonate (Na2CO3) in the tea bag, For the purpose of lowering the redox potential (ORP), sodium carbonate (Na2CO3) is put inside the tea bag together with rooibos tea and the redox potential (
ORP), reducing power is strong and active oxygen scavenging ability is high, for example, redox potential (ORP) is -50mv, -100mv, -150mv, or -200mv or more aqueous solution with reducing power Or, use rooibos tea and sodium carbonate (Na2CO3) containing drinking water inside the tea bag to reduce the redox potential (ORP) and increase the reducing power as much as possible. Using a tea bag containing tea and sodium carbonate (Na2CO3) together, the sodium carbonate (Na2CO3) contained in the tea bag is released or separated to release sodium ions (Na +) or hydrogen ions (H +). By dissolving in an aqueous solution, redox potential (OR
An aqueous solution that has a strong reducing power, similar to groundwater in the Kingdom of Hunza,
Or anytime, anywhere, food ingredients, foods, health foods, drinking water, characterized by alkaline extraction using rooibos tea and sodium carbonate (Na2CO3) that can be conveniently placed in tea bags Drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and manufacturing methods thereof.

In addition, rooibos tea, or mangroves, pine nut shells, green tea, or black tea,
Hydrogen contained in rooibos tea leaves, which are tea leaves such as brown rice tea, oolong tea, puer tea, or other herbal tea, or coffee (hereinafter abbreviated as rooibos tea) The ion (H +) is, for example, vitamin C contained in a rooibos tea leaf, or a hydrogen ion (H +) covalently bonded to a polyphenol or the like. To release or dissociate (H +) from vitamin C or polyphenols, use a heated aqueous solution or cold water in which an alkaline substance such as sodium carbonate (Na2CO3) is dissolved, for example, a PH concentration of 8.5 or more. Vitamin C,
Alternatively, hydrogen ions (H +) that are covalently bonded to polyphenols are liberated or dissociated, and active hydrogen ions (H +) with a high concentration of active hydrogen (negative ions) and negative redox potential are dissolved. Food raw materials, foods, and health that can be easily released or separated from rooibos tea leaves anytime, anywhere. Food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). , For example, a tea bag with 0.05 g or more or 0.2 g of sodium carbonate (Na2CO3) in the inside of a tea bag containing 1.0 g or more of rooibos tea. Boil the boiling water
After putting a tea bag inside the tea cup containing about 220ml and measuring the amount of active hydrogen (negative ions) in the aqueous solution inside the tea cup, the first few minutes after putting the tea bag inside the hot water The redox potential (ORP) is a reducing power around -140 mV, but the redox potential (ORP) after 30 minutes decreases to around -95 mV, and the redox potential (ORP) after 1 hour is + The result of this experiment, which drops to around 5mv, means that Rooibos and sodium carbonate
Active hydrogen ion inside tea cup using tea bag with (Na2CO3)
The above experimental results show that even if (H +) is generated, active hydrogen ions (H +) evaporate from the aqueous solution inside the tea cup and disappear within a time of about 1 hour. From the above experimental results, it is the water of Mexico's miracle water (Trachote), or the water of Germany's miracle (
(Nordenau) or similar to the water of the miracle of the Hunza Kingdom (active hydrogen) containing a large amount of (active hydrogen water), rooibos tea and sodium carbonate (Na2CO3) inside the tea cup
The above experimental results show that it has been successfully generated using and has been found to be the most effective to drink within 30 minutes for effective drinking, From the above experimental results, tea leaves such as rooibos tea, or the leaves of tea leaves such as rooibos tea that contains the hydrogen atoms (active hydrogen) contained in the leaves of other plants, Using tea bags with leaves and sodium carbonate (Na2CO3) together, boiling water,
Or to drink active hydrogen water, which is an aqueous solution containing a large amount of active hydrogen (hydrogen atoms) released or separated from active hydrogen (hydrogen atoms) inside a tea cup containing cold water,
Using the tea bag as described above inside the tea cup, it is the effect of eliminating the most active oxygen to drink around 30 minutes after the alkali extraction or within a maximum of 1 hour. It can be judged from the above experimental results that active hydrogen water containing strong active hydrogen is generated. It is the miracle water of Mexico that contains a large amount of active hydrogen (Tracote) Active water containing exactly the same amount of active hydrogen as the amount of active hydrogen (negative ions) contained in the water of Germany, water in Germany (Nordenau), or water in the Kingdom of Hunza To make and drink active hydrogen water containing active hydrogen most effectively anytime, anywhere, rooibos tea and sodium carbonate (Na2CO
If active hydrogen water containing active hydrogen is not generated using the tea bag containing 3), active hydrogen is the lightest atomic number, so it can be seen from the above experimental results. In addition, in about 30 minutes from the aqueous solution in which the active hydrogen is generated, the active hydrogen evaporates and escapes, so leaves of tea such as rooibos tea or leaves of other plants and sodium carbonate (N
In addition to generating active hydrogen in an aqueous solution using a tea bag containing an alkaline substance such as a2CO3) in the inside of the tea bag, it is the freshest and most effective action to eliminate active oxygen for 30 minutes Since it is not possible to drink the drinking water in which the active hydrogen is generated, the active hydrogen water containing the active hydrogen can be simply provided using a tea bag. In addition, the aqueous solution used in the experiment to inactivate the hepatitis virus using the hepatitis virus infected by the mouse, conducted at the National Institute of Infectious Diseases, shown in the graph (1),
Hepatitis that infects rats when using an aqueous solution in which a tea bag containing rooibos tea and sodium carbonate (Na2CO3) is immersed in a boiling tea cup for 30 minutes to generate active hydrogen. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic beverages characterized by the fact that active hydrogen can also inactivate viruses because they were able to inactivate viruses Water, shochu raw material, tea bag raw material, tea bag, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangroves, pine nut shells, green tea, or black tea,
Or a tea such as pigeon tea, barley tea, brown rice tea, oolong tea, puer tea, or other herbal tea, coffee, or a dry dried oak tree chip, or cherry tree chip, or apple Wood chip, or beech tree chip, oak tree chip, walnut tree chip, hickory tree chip, maple tree chip, oak tree, cherry tree, beech Wood chips, oak trees, maple trees, etc., or birch wood chips, or other wood chips, green tea, black tea, chlorella, chlorella tea, Tochu tea, barley tea, brown rice tea, coffee , Cocoa, octagonal fine powder, pine nut powder, mangrove trunk and branch and leaf powder, rosaceae tea
Yellow effect (Pei-chi tea), cat's claws (cat crow tea), kuzuka (kagikazura tea), Tahibo tea native to the Amazon, Rooibos tea native to Africa, eye-drop tea (Megsurinoki tea)
, Indian Neem Gymnema, Rafu Hemp Tea, Cod Leaf Tea, Iperoscha Tea, Umeyama Shusui Tea, Propolis Tea, Ganoderma Tea, Chitosan Tea, Sashigoka Tea (Yushou Tea), Fucha Tea (Puer Tea) , Turmeric tea, carrot tea, dokudami tea, tomorrow leaf tea (Ashitaba tea), candy tea tea (Amacha tea), aloe tea, ginkgo leaf tea, oolong tea, psyllium tea, oyster leaf tea, garcinia tea, gymnema tea,
Guava tea, rich tea, Kumazasa tea, mulberry leaf tea, sijuum tea, perilla leaf tea, jasmine tea, sugina tea, buckwheat tea, tabebuya tea, cod leaf tea, ten tea, dokudami tea, herbal tea, ning tea Ninhon tea), pearl barley tea, banaba tea, hub tea, loquat leaf tea, ratio tea (Pei Chi tea),
Mate tea, Umeyama Shusui tea, Eucalyptus tea, mugwort tea, Rakanka tea, Rakuma tea, Longi tea (Longines tea), or other herbal medicine ginseng, licorice, ground yellow, juju or Chinese medicine Kakkon, Toki, Shakuyaku, Ginger, Koboku, Rokujou, or Chinese herbal medicine, Bushi, Hanka, A tea bag containing 4.0 g of rooibos tea, such as Daio, Kyonin (hereinafter abbreviated as grass root bark, or herbal medicine, or rooibos tea)
Sodium carbonate, which is sodium bicarbonate (NaHCO3), sodium carbonate (Na2CO3), or other alkaline substance (hereinafter abbreviated as sodium carbonate (Na2CO3))
A tea bag made with about 0.2 g of (Na2CO3) together is put inside a tea cup containing about 220 ml of boiling hot water, and the inside of the tea cup with alkali extraction When measuring the amount of active hydrogen (negative ions) in the aqueous solution, the redox potential (ORP) was reduced to around -140 mV for 30 minutes after the tea bag was first placed in the hot water for 30 minutes. The later oxidation-reduction potential (ORP) decreases to about -95 mV, and the oxidation-reduction potential (ORP) after 1 hour decreases to about +5 mV. Also, as a control, only Rooibos tea
Using a tea bag containing 4.0 g, boiled boiling water under the same conditions as above.
A tea bag containing only 4.0 g of rooibos tea in a tea cup containing about 0 ml was extracted with hot water, and the redox potential (ORP) of the rooibos-only extract was +25 mV. What the above experimental results mean is that Rooibos and sodium carbonate
Active hydrogen ion inside tea cup using tea bag with (Na2CO3)
The above experimental results show that even if (H +) is generated, active hydrogen ions (H +) evaporate from the aqueous solution inside the tea cup and disappear within a time of about 1 hour. From the above experimental results, it is the water of Mexico's miracle water (Trachote), or the water of Germany's miracle (
(Nordenau) or similar to the water of the miracle of the Hunza Kingdom (active hydrogen) containing a large amount of (active hydrogen water), rooibos tea and sodium carbonate (Na2CO3) inside the tea cup
The above experimental results show that it has been successfully generated using and has been found to be the most effective to drink within 30 minutes for effective drinking, From the above experimental results, tea leaves such as rooibos tea, or the leaves of tea leaves such as rooibos tea that contains the hydrogen atoms (active hydrogen) contained in the leaves of other plants, Using tea bags with leaves and sodium carbonate (Na2CO3) together, boiling water,
Or to drink active hydrogen water, which is an aqueous solution containing a large amount of active hydrogen (hydrogen atoms) released or separated from active hydrogen (hydrogen atoms) inside a tea cup containing cold water,
Using the tea bag as described above inside the tea cup, it is the effect of eliminating the most active oxygen to drink around 30 minutes after the alkali extraction or within a maximum of 1 hour. It can be judged from the above experimental results that it has been found that active hydrogen water containing active hydrogen is generated, which is a miracle water in Mexico that contains a large amount of active hydrogen (Tracote ), Or the water of Germany (miraden water) (Nordenau), or the amount of active hydrogen (negative ions) contained in the miracle water of the Hunza Kingdom Anytime, anywhere to make water, the most effective way to create and drink active hydrogen water containing active hydrogen is to use rooibos and sodium carbonate (N
If active hydrogen water containing active hydrogen is not generated using a tea bag containing a2CO3), active hydrogen is the lightest atomic number, so it can be seen from the above experimental results. In addition, the active hydrogen evaporates and escapes in about 30 minutes from the aqueous solution in which the active hydrogen is generated, so leaves of tea such as rooibos tea or leaves of other plants and sodium carbonate (Na2CO3), etc. In addition to generating active hydrogen in the aqueous solution using a tea bag with the alkaline substance in the inside of the tea bag, the freshest and most active oxygen scavenging action is effective within 30 minutes Since you cannot drink the drinking water that generated hydrogen,
It is characterized in that active hydrogen water containing active hydrogen can be easily provided using a tea bag. In addition, the aqueous solution used in the experiment to inactivate the hepatitis virus using the hepatitis virus infected by the mouse, which was conducted at the National Institute of Infectious Diseases shown in the graph (1), was also used with rooibos tea and sodium carbonate ( Inactivating the hepatitis virus that infects rats when using an aqueous solution in which tea bags containing Na2CO3) are immersed in boiling tea water for 30 minutes to generate active hydrogen. It has been proved that active hydrogen can inactivate viruses as well, food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tea Bag raw material, tea bag, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, barley, roasted wheat (hereinafter referred to as roasted) barley tea, or cereals such as brown rice, white rice, rice bran, rice bran, for example, brown rice tea, or roasted soybeans, red beans, coffee beans For example, coffee or cocoa roasted cacao beans (hereinafter abbreviated as barley tea), for example, an alkaline substance (hereinafter abbreviated as sodium carbonate) inside a tea bag containing 4.0 g of barley tea (Na2CO3) A tea bag made with sodium carbonate (Na2CO3) of about 0.3 is put in a tea cup containing about 220 ml of boiling hot water. When the amount of active hydrogen (negative ions) in an aqueous solution extracted with an alkali using a tea bag is measured inside the tea cup, the redox potential (ORP)
Is a reducing power of around -331mv, while using a tea bag with 4.0g of barley tea inside the tea bag as a control, 220m of boiling hot water is the same condition as above
It was found that the redox potential (ORP) extracted with hot water inside the tea cup containing about l was a reducing power around -62 mV. It can be judged from the above experimental results that
The amount of active hydrogen contained in the water of Mexico's miracle water (Trakote), the water of Germany's miracle water (Nordenau), or the water of the Hunza miracle water Active water containing active hydrogen exactly the same as negative ions) or drinking water containing active hydrogen more than the amount of active hydrogen (negative ions) contained in the miracle water By creating a tea bag that contains barley tea and sodium carbonate (Na2CO3) inside the bag, it becomes possible to easily generate drinking water containing a large amount of active hydrogen. However, the present invention is characterized in that it can drink active hydrogen water containing a large amount of active hydrogen. Also, in the case of coffee,
The redox potential (ORP) obtained by alkaline extraction using a tea bag containing 6.0 g of coffee powder and 0.3 g of sodium carbonate (Na2CO3) inside the tea bag is a reducing power of around -153 mV. On the other hand, control was found to have a reducing power of around -10mv. From the above, it was discovered that active hydrogen with the effect of eliminating active hydrogen can be easily generated in large quantities using tea bags, and this is the main lifestyle-related disease that causes human illness. It has been reported that 90% of diseases are caused by active oxygen. For example, active oxygen has a strong oxidizing power and an oxidation-reduction potential (ORP) of +800 mV or higher, and the mechanism of cancer development is that the active oxygen damages the oncogene and causes mutations, triggering cancer and causing cancer. Such as active hydrogen erases active oxygen, active hydrogen is a lifestyle-related disease, arteriosclerosis, ischemic heart disease, cerebral ischemia, dementia, cataract, emphysema, inflammation, ulcerative colitis, aging ,
Prevention, treatment of life-style related diseases caused by active oxygen such as diabetes, allergy, atopy, asthma, skin diseases, respiratory diseases, arthritis, etc., treatment of patients with viral diseases due to antiviral effects, and AIDS patients To generate active hydrogen, which is said to be effective when drinking an aqueous solution containing active hydrogen in the treatment of intractable diseases such as patients with viral hepatitis and patients with other viral diseases It is an alkaline substance contained in the inside of the tea bag, for example, using sodium carbonate (Na2CO3), etc., by simple alkali extraction, grains such as barley, brown rice, beans such as coffee beans, or Using a tea bag to perform alkaline extraction of active hydrogen that contains and covalently binds grass root bark such as green tea and tea leaves As a result, active hydrogen is released or separated to generate active hydrogen, food raw material, food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tea bag raw material , Tea bags, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

In addition, 11 types of catechins shown in Table 10 (hereinafter abbreviated to epigallocatechin gallate (EGCg) or catechin (EGCg) as representative catechins are effective as drugs, influenza virus, AIDS virus) Although it has been found that it can inactivate viruses or bacteria in vitro in a variety of other viruses such as HCV, or papilloma virus, or bacteria such as MRSA Since catechin has a drawback that it is easily degraded in the intestinal tract, which is the digestive tract, 99% or more of the active ingredients of catechin easily decompose in the intestinal tract even if catechin is administered orally, Since there are drawbacks that are not absorbed, catechin is currently administered orally or applied to the nasal mucosa, or sprayed on the nose as a nasal drop The current situation is that no drugs such as nasal sprays have been developed, and catechins, which are the disadvantages of catechins, are unstable in the digestive tract. In order to change the chemical structure of catechin with chemical structure to the chemical structure of catechin with chemically stable catechin, enzyme lipase is used as a component of catechin, and fatty acid is added to epigallocatechin gallate, which is a component of catechin. A new epigallocatechin gallate compound or catechin compound (hereinafter abbreviated as catechin, epigallocatechin gallate compound, or epigallocatechin derivative, catechin compound, or catechin) A derivative)
Because catechin derivatives change to substances that do not decompose in the digestive tract, the names of diseases intended for oral administration or nasal spray include malaria, sleeping sickness, AIDS, hepatitis C, adult leukemia, and influenza Oral administration such as tablets, capsules, or liquids, or nasal sprays formed using catechin derivatives intended for oral administration or nasal sprays for the purpose of treating infectious diseases of It was possible to develop drugs that could be performed.

Furthermore, the unstable chemical structure of catechin, which is a drawback of catechin, for the purpose of developing a drug for the purpose of oral administration, intraperitoneal administration, or intravenous administration of catechin as described above. In order to change the chemical structure of catechin to a chemically stable chemical structure for the purpose of changing the properties of the catechins, the following (1) , (2), (3), (4), (5), and (6) can cause a catechin derivative to form a catechin derivative by causing a condensation reaction that is a chemical reaction to form a catechin derivative. Since the chemical structure is chemically stable, a drug can be formed for the purpose of catechin or nasal spray, oral administration, intraperitoneal administration, or intravenous administration.

As (1), catechin and iron are subjected to a condensation reaction to form a new compound, catechin derivative.

As (2), catechin and caffeine are subjected to a condensation reaction to form a new compound, catechin derivative.

As (3), catechin and tannin are subjected to a condensation reaction to form a new catechin derivative.

As (4), catechin and a fatty acid are subjected to a condensation reaction to form a new catechin derivative.

As (5), a catechin derivative, which is a new compound, is formed by a condensation reaction between catechin and protein, sugar chain, lipid, and the like.

As for (6), the virus that causes cervical cancer and endometrial cancer (hereinafter abbreviated as cervical cancer) is papillomavirus (HPV) (hereinafter abbreviated as HPV). . this
As a therapeutic means for treating cervical cancer that develops due to HPV, it is described below (a),
The purpose is R & D on the development of three types of treatment methods (b) and (c).

(a) As a main drug, epigallocatechin gallate (EGCg), or other catechin (hereinafter abbreviated as catechin) and palm oil, or vagina used by women by mixing catechin and hard hat oil By developing a suppository and inserting a vaginal suppository into the vagina of a woman who has developed cervical cancer and applying catechin on the surface of the uterus, HPV, the virus causing cervical cancer, is killed The purpose of this study is to develop a therapeutic method for treating cervical cancer.

As for (b), catechin easily decomposes in the intestinal tract, which is a digestive organ, for the purpose of oral administration for treating cervical cancer or the development of an internal medicine intended for nasal spray. Therefore, in order to change the unstable chemical structure of catechin to a chemically stable chemical structure, for example, a catechin and a fatty acid are subjected to a condensation reaction using an enzyme lipase and chemically stabilized with catechin. A catechin derivative or a catechin compound (hereinafter abbreviated as catechin or a catechin derivative) to which fatty acid is condensed and bonded is synthesized, and the catechin derivative is introduced into the blood from the intestinal tract of a female patient who has developed cervical cancer. The purpose of this research is to develop a therapeutic method for treating cervical cancer with the aim of killing HPV dissolved in blood and HPV growing in the uterus. .

As (c), HP, which is a causative virus for developing cervical cancer, by direct intraperitoneal administration of catechin as a single catechin or intravenous administration of catechin as a single catechin
V, HPV dissolved in blood using catechin injected into the blood and HPV growing in the uterus, HPV using the effect of catechin inactivating HPV The purpose of this study is to develop a therapeutic method for treating cervical cancer with the aim of killing it.

In addition to the resistant malaria parasites shown in Table 10, a combination of catechin and artesunate or catechin and chloroquine in combination with two drugs each inactivated the resistant malaria parasite in recent years. The existing drugs oseltamivir (hereinafter abbreviated as Tamiflu), xanavir (hereinafter abbreviated as Relenza), and simmetrel (hereinafter abbreviated as amantadine) The mechanism of action of Tamiflu and Relenza as two types of drugs suppresses the action of neuraminidase, a protein necessary for the virus that has grown inside the cell to go outside the cell. Because Tamiflu and Relenza are the same drugs, they are exactly the same drug. The mechanism of action of other existing drugs, amandadin, as a drug is the action that suppresses the action of M2, a protein required immediately after the virus goes out of the cell. It is a drug that is different from the action effect. In addition, the headquarters of Toyama Chemical in Tokyo is conducting clinical trials, and the mechanism of action of T-705, an anti-influenza drug, is the mechanism of action by using polymerase, a protein that constitutes the influenza virus gene. Since the function of the polymerase is suppressed inside the cell, the replication of the influenza virus itself is suppressed, and there is an advantage that a resistant influenza virus cannot be produced. T-705 under development with 3 existing drugs and currently undergoing phase 2 clinical trials
In addition, Tamiflu suppresses the action of a protein named neuraminidase.
The mechanism of action of amandadin as a drug suppresses the action of a protein named M2. T-
The effect of the 705 mechanism of action suppresses the action of the protein named polymerase.
Although there is a difference between the above four types of influenza drugs that suppress the action of the protein outside the cell or the action of the protein inside the cell, the common matter is to suppress the action of the protein. There are four influenza cases, including the three types of influenza drugs described above and one of the clinical drugs at the clinical trial stage. It is the biggest feature of a therapeutic drug. The feature of these four influenza drugs is the greatest characteristic common to the four influenza drugs described above that suppresses the action of the proteins constituting the influenza virus. As described above, the relationship between flukins and catechins, a total of 4 cases, including 3 existing anti-influenza drugs and 1 clinical trial stage, is shown below (1), (2 ), (3)
And (4).

As for (1), three types of influenza drugs, Tamiflu, Relenza, and Amandadine, which have been described above and aimed to suppress the action of influenza virus, are currently being developed in clinical trials. The relationship between catechins and 4 flu drugs, including 1 T-705, is exactly the same as the active ingredients of astringent astringent as catechins. The greatest feature of catechins is that the condensation reaction with miscellaneous proteins, sugar chains, lipids, and fatty acids is strong and has a strong property of forming a condensation bond. In particular, catechin has a strong property of causing a condensation reaction with all proteins that are variously different from proteins and has a strong condensation bond.

As for (2), it has been proved that catechins can inactivate influenza virus, AIDS virus, or other various other viruses in the experiment inside the test tube. It was. However, since catechin has an unstable chemical structure, catechin is decomposed in the intestinal tract of the digestive tract even if catechin alone is administered orally with catechin alone. Was thought to be a non-occurring substance. In addition, since catechin undergoes a strong condensation reaction with proteins and forms a condensation bond and is excreted outside the human body, catechin is not administered intraperitoneally or catechin is administered intravenously at present. It is.

As (3), when catechin alone with only catechin is administered to the human body, catechin is injected into the abdominal cavity of the human body using a syringe so that it can be judged from the experimental results in Table 10. If catechin is administered directly into the peritoneal cavity or administered intravenously using a syringe into the human body, the catechin is inherently retained without being degraded in the intestinal tract of the digestive tract. It is possible to exert the action and effect as a drug. The experimental results in Table 10 show that. However, as can be seen from the experimental results in Table 10, 500 m / kg.
All mice die when g catechin is administered. However, it is a great discovery that mice were found not to die after administration of 50 mg of catechin per kg. Also per kg
The fact that catechin was successfully inactivated by using catechins of 50 mg or less and that catechin was effective against malaria parasites was also a great discovery. From this, catechin is directly administered intraperitoneally as catechin as a medicine, or catechin is directly administered intravenously, AIDS virus, hepatitis C virus, influenza virus, herpes virus, papilloma virus, adult leukemia virus, The development of therapeutics for infectious diseases such as Trypanosoma protozoa, resistant Spirochetaparida, resistant Mycobacterium tuberculosis, and malaria (hereinafter abbreviated as infectious disease) can be performed using catechins. It can be said that this is a great discovery in the development of therapeutic methods aimed at eradicating future infectious diseases.

As for (4), since catechin is unstable in chemical structure, it is easily decomposed in the intestinal tract of the digestive tract, so existing antibiotics, pharmaceuticals, and chemicals, for example, are currently used with resistance. Antibiotics such as penicillin, streptomycin, artemisinin (also known as artesunate), quinine, chloroquine, Tamiflu, Relenza, and amandadine (hereinafter abbreviated as typical examples, penicillin or artemisinin) A catechin derivative, or a regenerated penicillin, or a regenerated penicillin derivative, or a regenerated artemisinin, or an artemisinin derivative (hereinafter abbreviated as a catechin derivative, or Regenerated penicillin or penicillin derivative or regenerated A catechin derivative having a chemical structure that cannot be renewed, or a regenerated penicillin, or a penicillin derivative, or a regenerated artemisinin, or an artemisinin derivative. The unstable chemical structure of catechin becomes a chemically stable chemical structure, and the chemical structure of catechin is chemically maintained while maintaining the original properties of catechin, the original properties of penicillin, or the original properties of artemisinin. Since it stabilizes, the catechin is not decomposed in the intestinal tract of the digestive tract even if it is administered orally. Also,
The catechin derivative, regenerated penicillin, or penicillin derivative, or regenerated artemisinin, or artemisinin derivative may be administered intraperitoneally and intravenously as a means of administration other than oral administration.

In addition, the purpose is to develop a very simple and effective treatment method that is extremely inexpensive, has no side effects, and has no side effects when infected with a highly toxic influenza virus such as H5N1 In the influenza virus epigallocatechin gallate (EGCg),
Or when other catechins (hereinafter abbreviated as catechins) are administered orally, the chemical structure of catechins is unstable, and therefore the chemical structure of catechins is easily degraded in the intestinal tract, the digestive tract. There are drawbacks. Catechin is antiviral or antibacterial in vitro,
Or catechin is said to have a strong anticancer effect, but catechin has not been applied to pharmaceuticals because it has a chemical structure that is unstable and easily degraded in the intestine. is there. Therefore, for the purpose of avoiding the degradation of catechin in the intestinal tract, the digestive organ, which is a disadvantage of catechin, the catechin is bypassed through the intestinal tract, the digestive organ, and avoids the human intestinal tract to the human body. For the purpose of direct administration, catechin is directly administered intraperitoneally, or catechin is directly administered intravenously to dissolve in the blood and float in the organs Treatment of patients with influenza who are infected with a highly toxic influenza virus such as H5N1 by injecting flu virus into the blood and directly injecting catechin into the blood or intraperitoneally administering catechin The purpose is to conduct research and development for the purpose of research and development of treatment methods for influenza patients. In addition, by direct intraperitoneal administration of catechin, or by direct intravenous administration of catechin, the disease name is caused by Trypanosoma protozoa, sleep disease, or disease name is Nagana disease,
Or the disease is caused by protozoan malaria, the disease name is malaria, or the death of cancer cells, or the cancer cells are killed in the blood, the disease name is a therapeutic means for eradicating cancer

In addition, as described above, as a therapeutic means for injecting catechin directly into the human body without passing through the intestinal tract that is the digestive organ of the human body, The catechin is used as a treatment method for patients other than avian influenza patients whose disease name is avian flu, such as the highly toxic H5N1 type that is directly administered intravenously and explained above. As a therapeutic means shown in the following (a), (b), (c), (d) and (e) by directly intraperitoneally administering catechin or intravenously catechin directly There is a usage method.
As (a), there is a utilization method as a treatment method for chickens infected with avian influenza virus whose disease name is avian influenza, such as highly toxic H5N1 type.
As for (b), there is a method of use as a treatment method for a sleep disease whose disease name is caused by infection of a human being caused by Trypanosoma protozoa.
As (c), there is a method of use as a treatment method for Nagana disease whose disease name is caused by infection of livestock such as cattle, horses, goats, etc. due to Trypanosoma protozoa.
As (d), there is a method in which the name of a disease that develops due to a malaria parasite is used as a means of treating malaria.
As (e), there is a method of using cancer cells as killing cancer cells or killing cancer cells in the blood as a means for treating cancer.
In conclusion, the treatment means shown in (a), (b), (c), (d) and (e) above are used.

Furthermore, catechin alone or catechin alone, or as a therapeutic means for the treatment of influenza patients with catechin as the main component, orally for the purpose of treating simple and inexpensive treatment of influenza patients, oral administration, Or it is an internal medicine for the purpose of treating influenza patients with catechin as the main component for nasal spray.

Moreover, since catechin is a chemical substance having a chemically unstable chemical structure, catechin is a substance that is easily decomposed in the intestinal tract, which is the digestive organ. Therefore, for example, using an enzyme lipase, epigallocatechin gallate (EGCg), which is the main main component of catechin, or fatty acid is introduced into other catechins to create a catechin compound having a new chemical structure, Research and development of oral medicine for the treatment of influenza patients, oral medicine for nasal spray, or intraperitoneal medicine or intravenous medicine was conducted.

In addition, there are currently three types of drugs, Tamiflu, Relenza, and Amantadine, which are existing drugs for oral administration, whose disease name is for the treatment of influenza. I am doing. However, Tamiflu, Relenza, and Amantadine explained above are all in the state where resistant influenza virus strains are completely produced, or resistant influenza virus strains are emerging, In the near future, it may be considered that the effects of the three types of influenza drugs, Tamiflu, Relenza, and Amantadine described above, will be halved or completely disappear in the near future. Therefore, as a solution, the following (a), (b), (c), (d)
And the research and development shown in (e) is carried out to obtain regenerated Tamiflu, regenerated relanza, and regenerated amantadine.

As (a), a condensed reaction is caused to catechin and Tamiflu which are unstable in chemical structure and easily undergo a condensation reaction to form a regenerated Tamiflu which is a new Tamiflu.

Furthermore, as (b), a condensation reaction is caused between catechin and rerenza to form a regenerated rerenza which is a new rerenza.

As (c), a condensation reaction is caused between catechin and amantadine to form regenerated amantadine, which is a new amantadine.

Furthermore, as (d), four types of catechin, Tamiflu, Relenza, and amantadine are mixed to cause a condensation reaction centering on three types of drugs and catechin to form a mixture of four types of influenza drugs. Therefore, existing influenza drugs that have emerged against existing Tamiflu, Relenza, amantadine, or existing medicines that have half the effect as pharmaceuticals in the middle of the emergence of resistant influenza virus strains In the future, Tamiflu, or Relenza, or Amantadine, a Tamiflu derivative, or a complex chemical structure in which resistant influenza virus strains cannot emerge using catechin in the future, By changing to Relenza derivative or Amantadine derivative, strong poison type H5N1 The name of the disease is intended to treat influenza patients with the aim of dealing with influenza viruses such as types or resistant influenza virus strains.

As for (e), the above-described method for taking Tamiflu and amantadine is a tablet or powder internal medicine intended for oral administration, and a drug whose disease name is intended for the treatment of influenza. Relenza is a drug that is inhaled in powder form and whose name is intended to treat influenza. When Tamiflu, Amantadine, and Relenza (hereinafter referred to as Tamiflu for short) are taken orally or nasally, catechin is taken together with catechin, which is completely different from the nasal administration method. Even if catechin is administered by intraperitoneal administration or intravenous administration, which is completely different from the method of taking catechin, catechin and Tamiflu cause a condensation reaction in the blood of the human body, catechin derivatives, or Tamiflu derivatives, Alternatively, by becoming an amantadine derivative or a rerenza derivative, the disease name is intended to avoid influenza virus strains resistant to Tamiflu, amantadine, and rerenza, and is a therapeutic means for patients with influenza.

Further, as described above, using an enzyme lipase for catechin, fatty acid is introduced into epigallocatechin gallate (EGCg), which is a component of catechin, or other catechin (hereinafter referred to as catechin). When a new catechin compound (hereinafter abbreviated as catechin or a catechin derivative) is synthesized, the catechin derivative improves the permeability of the cell membrane. Inactivating or killing virus (HIV), hepatitis C virus (HCV), herpes virus, influenza virus, trypanosoma protozoa, spirochete parida protozoa, and malaria protozoa (hereinafter abbreviated as infectious diseases), It becomes stronger. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means whose disease name is intended to treat influenza.

Catechin extracted from tea catechins and purified using catechin as the main raw material is a substance that is easily degraded in the intestinal tract of the digestive tract. However, catechin extracted from tea is absorbed in the intestine and into the blood Although it is a substance that dissolves, for the purpose of further absorbing catechins in the intestinal tract, catechin derivatives in which fatty acids are introduced into catechins using enzyme lipase and catechins pass through cell membranes or protect bacteria. In the blood in the intestinal tract, the permeability of the bacterial membrane that is the epidermis of the bacteria, the permeability of the envelope membrane that is the epidermis of the virus protecting the nucleic acid of the virus, or the permeability of the cancer cell membrane Compared with conventional catechins, the efficiency of dissolution is further improved, so that the anticancer effect of catechins, the antibacterial effect of catechins, or Although the antiviral activity of quinchin is stronger than that of conventional catechins, catechin derivatives in which fatty acids are introduced into conventional catechins are even stronger. The catechin derivative into which fatty acids have been introduced is used in the research and development of the therapeutic means, and the therapeutic name is intended to treat infectious diseases such as influenza.

Furthermore, the treatment method for herpes simplex and herpes zoster patients whose herpes virus causes herpes simplex virus infection is extremely inexpensive, has no side effects, and is extremely simple and effective. To develop herpesvirus, epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) is directly administered intraperitoneally, or catechin is directly administered intravenously. Infection with herpes virus by direct injection of catechin into the blood with herpes virus dissolved in the blood and suspended in the blood or herpes virus growing in cells As a treatment method for patients with herpes simplex herpes simplex virus infection and herpes zoster.

In addition, as described above, herpes simplex virus infection herpes simplex and herpes zoster treatment means, by Gertrude Elion of Burroughs Welcome Institute,
The antiviral agent acyclovir (aciclovir) has been developed as a specific medicine. However, a herpesvirus strain resistant to acyclovir has already emerged. In order to avoid this herpesvirus strain resistant to acyclovir, either acyclovir and catechin are used in combination to cause acyclovir and catechin to undergo condensation reaction in the human body, or acyclovir and catechin are mixed to produce catechin. And acyclovir are allowed to undergo a condensation reaction,
A regenerative acyclovir is prepared as a therapeutic means for inactivating or killing a resistant herpesvirus strain.

Furthermore, artesunate whose disease name is malaria, is currently not used as a therapeutic drug due to the emergence of resistant malaria parasites, or the effect as a drug has been reduced (artemisinin is hydrophobic to artemisinin) (Artesunate is a hydrophilic substance that dissolves artemisinin in water), quinine, or a drug that treats malaria with the name of malaria and has some side effects, but is currently the cheapest drug. As a therapeutic drug, chloroquine, which is rarely used as a therapeutic drug, is regenerated, and again used as a therapeutic means as a therapeutic drug for malaria.

In addition, for the purpose of avoiding artesunate-resistant malaria parasite that is less sensitive to artesunate_, epigallocatechin gallate (EGCg), or other catechin (hereinafter abbreviated as catechin) and artesunate in combination, Alternatively, catechin and artesunate are mixed and catechin and artesunate are subjected to a condensation reaction to create a compound similar to the new artesunate derivative, which is caused by an artesunate-resistant malaria parasite that is less sensitive to artesunate. The treatment is aimed at treating malaria with the onset of disease.

Furthermore, for the purpose of avoiding chloroquine-resistant malaria parasites that are less sensitive to chloroquine, catechin and chloroquine are used together, or catechin and chloroquine are mixed together to cause condensation reaction of catechin and chloroquine, thereby creating a new compound A compound similar to the chloroquine derivative is prepared and used as a therapeutic means for the treatment of malaria whose name is caused by a chloroquine-resistant malaria parasite that is less sensitive to chloroquine.

Moreover, it is set as the therapeutic means aiming at performing the treatment of the disease name malaria using catechin using the catechin single-piece | unit demonstrated above.

Furthermore, epigallocatechin gallate (EGCg), which is a component of catechin using the enzyme lipase described in (3), (4), and (5) above, or other catechins (
Hereinafter, when a fatty acid is introduced into catechin (abbreviated for short) and a new catechin compound (hereinafter abbreviated as catechin or catechin derivative) is synthesized, the catechin derivative is improved in cell membrane permeability. Compared with conventional catechins, catechin derivatives introduced with fatty acids inactivate AIDS virus (HIV), hepatitis C virus (HCV), herpes virus, influenza virus, trypanosoma protozoa, spirochete parida, and malaria protozoa, or The killing activity is even stronger. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means for treating a disease whose name is malaria.

The causative virus that causes cervical cancer and endometrial cancer (hereinafter abbreviated as cervical cancer) is papillomavirus (HPV) (hereinafter abbreviated as HPV). As a therapeutic means for treating cervical cancer that develops due to this HPV, the following are described (a), (b), and
(c) Three kinds of treatment means.

Furthermore, as (a), epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) and palm oil or catechin and hard hat oil are used as a main drug. HPV is the causative virus of cervical cancer by developing a vaginal suppository and inserting catechin on the surface of the uterus by inserting the vaginal suppository into the vagina of a woman who has developed cervical cancer Is a therapeutic means for treating cervical cancer for the purpose of inactivating or killing.

In addition, as (b), catechin was injected directly into the blood with HPV, which is the virus that causes cervical cancer, by direct intraperitoneal administration of catechin or intravenous administration of catechin directly. Use HPV dissolved in blood and HHPV growing in uterus,
The effect of catechin inactivating HPV is used to treat cervical cancer with the aim of killing HPV.

Furthermore, as (c), catechin is easily decomposed in the intestinal tract, which is a digestive organ, for the purpose of developing an internal medicine intended for oral administration for treating cervical cancer. Therefore, for example, in order to change the unstable chemical structure of catechin to a chemically stable chemical structure, for example, a catechin and a fatty acid are chemically stabilized by a condensation reaction of catechin and a fatty acid. A synthetic catechin derivative or a catechin compound (hereinafter abbreviated as catechin derivative) for oral administration is synthesized and used in the digestive tract of a female patient developing cervical cancer. Cervical cancer for the purpose of inactivating or killing HPV dissolved in blood and HPV growing in uterus by absorbing catechin derivatives into blood from a certain intestinal tract Is a therapeutic means of treating.

In addition, allicin, a substance contained in leeks, is said to be effective in preventing colds and having a disease name for influenza. The purpose of this cold prevention is to identify allicin, which is a substance contained in green onions whose disease name is said to be effective against influenza, and to identify compounds that are similar to allicin, and to research and development related to the synthesis of these compounds. .

Furthermore, epigallocatechin gallate (EGCg), which is a component of catechin, or other catechins (hereinafter abbreviated as catechin) has an unstable chemical structure. This catechin has an unstable chemical structure, which is characterized by a condensation reaction with proteins, sugar chains, lipids, minerals, and other substances, resulting in a chemically stable catechin. It is a substance with remarkable properties. When this catechin is used by applying a chemical structure in which the chemical structure of catechin is chemically unstable, for example, it is a first-generation antibiotic that was developed in the past in the past, and it is resistant and has not been used in the past. On the formation of new catechin derivatives, catechin complexes, or catechin compounds (hereinafter abbreviated as catechin derivatives) by causing condensation reactions of antibiotics, pharmaceuticals, and chemicals with catechins For development purposes. For example, the current antibiotics penicillin, streptomycin, the antiviral drug acyclovir, artemisinin (also known as artesunate), quinine, chloroquine, Tamiflu, which are drugs that are currently resistant and are not being used or are becoming resistant , Relenza, and amantadine (hereinafter abbreviated to be penicillin, or Tamiflu, or artemisinin, or chloroquine as a representative example) and catechin,
A regenerated penicillin derivative or a regenerated Tamiflu derivative that has a chemical structure that cannot be renewed by regenerating the past penicillin, Tamiflu, Artemisinin, or Chloroquine, which has already developed resistance, into another compound Alternatively, regeneration is performed by forming a regenerated artemisinin derivative or a regenerated chloroquine derivative.

In addition, the Chinese name containing artemisinin derivative (also known as artesunate) is yellow flower bud, and the Japanese name is xanthine, containing artemisinin derivative.
For the purpose of research and development regarding the comparison of the content of yellow flower pods containing artemisinin derivatives in each region that contains yellow flower pods cultivated in each region on the earth To do.

Furthermore, it aims at the research and development on elucidating why there is a big difference in the content of artemisinin derivative contained in yellow flower buds, which is cultivated in each region on the earth.

In addition, a study on the correlation between the content of artemisinin derivatives contained in yellow flower buds and the reproductive status of anopheles mosquitoes that carry malaria parasites whose disease name infects malaria. For example, the yellow flower moth that provides sap to an anopheles mosquito contaminated with malaria parasites is a substance similar to the antibody in the animal world that aims to protect its own body. The purpose of the research and development is to elucidate the mechanism of whether or not yellow flower buds are producing artemisinin derivatives as substances that have exactly the same effects.

In addition, catechins are used to inactivate Trypanosoma protozoa, which are pathogens for sleep diseases that cause illness in the human body and cattle, horses, goats, etc. Use as a means of treatment.

In addition, the use of a mixture of catechin and artesunate (hereinafter abbreviated as artesunate complex) or a mixture of catechin and chloroquine (hereinafter abbreviated as chloroquine complex) causes sleep diseases and pathogens of Nagana disease. Trypanosoma protozoa are used as a therapeutic means to inactivate using artesunate complex or chloroquine complex.

Further, as described above, using an enzyme lipase for catechin, fatty acid is introduced into epigallocatechin gallate (EGCg), which is a component of catechin, or other catechin (hereinafter referred to as catechin). When a new catechin compound (hereinafter abbreviated as catechin or a catechin derivative) is synthesized, the catechin derivative improves the permeability of the cell membrane. Compared with the conventional catechin, the catechin derivative introduced with a fatty acid is AIDS virus (HIV), hepatitis C virus (HCV), herpes virus, influenza virus,
The activity of inactivating or killing Trypanosoma protozoa, Spirocheta paridae, and malaria parasites is even stronger. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means for the treatment of sleep disease and Nagana disease.

In order to develop a very simple and effective treatment method for patients with hepatitis C virus (HCV) whose disease name is very inexpensive and has no side effects. Depending on the purpose, epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) is directly administered intraperitoneally as a treatment for patients with hepatitis C, or catechin is directly intravenous Injecting catechin into the blood directly by injecting the HCV floating in the blood and HCV proliferating in the organ into the blood In order to conduct research and development of a treatment method that directly kills HCV, an animal experiment using a chimpanzee infected with hepatitis C virus (HCV) was conducted. Use as a means of treatment.

Furthermore, for the purpose of developing a very simple and effective treatment method that is infected with AIDS virus (HIV), whose disease name is extremely inexpensive, no side effects, and has no side effects, As a treatment for AIDS patients, catechin is directly administered intraperitoneally, or catechin is directly administered intravenously, and budding on the surface of free HIV or cells floating in the blood. Research and development of therapeutic means that kills HIV directly in the blood by injecting HIV in the blood or catechin directly into the blood Therefore, animal experiments using rhesus monkeys infected with AIDS virus (HIV) or green monkeys are performed to treat AIDS patients.

In addition, as described above, with regard to the therapeutic means for hepatitis C patients and the therapeutic means for AIDS patients, hepatitis C directly administered intraperitoneally, catechin directly administered intravenously, and Use as a treatment for AIDS patients.
Furthermore, for the purpose of treating hepatitis C patients and AIDS patients, catechin was administered intraperitoneally,
Alternatively, a therapeutic means for treatment by intravenous administration is an expensive therapeutic means. Therefore, catechin is used as a medicine, and a simple and inexpensive oral administration is performed to treat hepatitis C patients and AIDS patients.
In addition, the purpose of this study is to research and develop internal medicines for oral administration for the purpose of treating hepatitis C patients and AIDS patients as described above. Since catechin is a chemical substance with a chemically unstable chemical structure, catechin is a substance that is easily decomposed in the intestinal tract, which is the digestive organ. Therefore, for example, using an enzyme lipase, epigallocatechin gallate (EGCg), which is the main main component of catechin, or introducing a fatty acid into other catechins to create a catechin compound having a new chemical structure, Therapeutic means intended for oral administration for the treatment of patients with hepatitis C and AIDS.

Furthermore, regarding the anti-influenza virus activity of catechin, the results of the experiment on the anti-influenza virus activity of catechin conducted by Prof. Masahiko Kurokawa of the second course of biochemistry of Kyushu University of Health and Welfare A report of the experimental results from Professor Masahiko Kurokawa is given below.

February 12, 2009 Report of catechin anti-influenza virus activity test results

the purpose

The anti-influenza virus activity of catechin (Sanphenon BG-3, Polyphenon 70S)
We examine using a mouse influenza virus nasal infection model.

experimental method

Catechin administration (peritoneal administration, 50 mg / kg x 2 times /
Infection with influenza virus to mice (BALB / 0, sputum, body weight 20-22g, 6 weeks old) via nasal infection (PR8 strain grown on MDCK cells, 500PFU / mouse) ) And
Body weight changes and survival after infection were investigated daily. Tamiflu (1mg / kg, poinjection, 1
The effect of combined use with twice a day for 5 days was also examined.

Experimental result

1. Examination of anti-influenza virus activity of catechin alone Catechin (BG-3, 70S) was administered intraperitoneally once before infection, and then catechin was administered twice a day.

Weight change (Fig.4)
-From day 1 to day 8 after infection, 70S alone significantly reduced weight loss due to infection from the early stage of infection.
・ By BG-3 administration alone, there was a tendency for weight loss due to infection to be suppressed in the late stage of infection (after 4 days).
-Between the first day and the eighth day after infection, the body weight loss due to infection was significantly suppressed by the administration of Tamiflu alone. However, the combined administration of the two catechins and Tamiflu did not significantly suppress weight loss due to infection.

Survival rate (survival days) (Fig.5)
・ No significant prolongation of survival days was observed by administration of two catechins alone until the 14th day after infection, but it seemed that the survival days of the BG-3 monotherapy group were prolonged. .
-Death of mice could not be confirmed up to 14 days after infection by single administration of Tamiflu or combination administration of two catechins and Tamiflu.

Consideration

Catechin (70S) significantly suppressed weight loss due to infection, and catechin (BG-3) appeared to prolong survival. For this reason, it is considered that the two catechins used exhibit some anti-influenza virus activity. Therefore, in the future, administration method, dosage,
It is considered that the effectiveness of catechin can be shown by conducting experiments taking into account the absorption efficiency in vivo. On the other hand, regarding the combined effects with Tamiflu, there are many considerations including the determination of Tamiflu single dose, so it is considered desirable to examine the effectiveness of catechin alone.

20081217
Examination of antiviral effect of Nagaura sample using influenza infected mice

Sample: 2 types of samples Sanphenon BG-3
2. Polyphenon 70S

Mouse: BALB / c, sputum, weight 20-22g, 6 weeks old, purchased from Kudo

Check item
(1) Weight change → Fig.4
(2) Days of survival → Fig.5

Sample adjustment sample
50mg / kg, ipinjection
Conduct twice a day for 5 days, at 9:00 and 19:00 in the morning
2. Tamiful
1mg / kg, ipinjection
Conduct twice a day for 5 days, at 9:00 and 19:00 in the morning

Joint research: Examination of catechins for preventing influenza infection by animal experiments_2009

Also shown in Fig. 6 is herpes simplex skin in which mice are infected by Prof. Kimiyasu Shiraki of the Department of Virology of Toyama University School of Medicine, Department of Virology, University of Toyama, Toyama City, and Dr. Yoshiaki Nagaura of the present inventor. Infection model herpesvirus (hereinafter abbreviated as herpesvirus)
It is evaluation of the experimental result regarding the effectiveness as a chemical | medical agent of a catechin with respect to the mouse | mouth which infected with this. 50mg / kg of mice infected with herpes virus twice a day with catechin
FIG. 6 shows the experimental results of intraperitoneal administration (50 mg × 2 ip per kg). According to the results of this experiment, as shown in FIG. 6, since the progression of the pathological condition was suppressed at the early stage of infection when mice were infected with herpes virus, the therapeutic effect of mice infected with catechins with herpes virus was improved. It was an experimental result that can be judged to be.

Furthermore, the difference between the influenza virus described in FIG. 4 and FIG. 5 above and the herpes virus which is the causative virus of herpes simplex skin infection also described in FIG. And the free influenza virus lyses in the blood by growing in the cells of the trachea, but the nature of herpesviruses is from the surface of cells infected with herpesvirus to the surface of another cell Since it is a virus, influenza virus and herpes virus are different viruses. The catechin has shown a drug effect on both the influenza virus dissolved in the blood and the virus present on the surface of the cells. FIG. 4, FIG. 5, and FIG. These are experimental results of mice infected with influenza virus and herpes virus.

Furthermore, in order for the human body to memorize immunity and the immune memory is established and the human body acquires immunity, (1)
The human body acquires immunity in the order of (4) to (4).

(1) includes antigens that have invaded the human body, such as viruses, bacteria, syphilis, protozoa, parasites, pollen, proteins, and peptides formed of five or more amino acids, such as macrophages It begins with phagocytic phagocytosis.

  As for (2), phagocytic cells present a part of the antigen to helper T cells.

As (3), the helper T cell further transmits information to the B cell, and causes the B cell to differentiate into a plasma cell having an antibody production ability capable of producing an antibody.

As for (4), plasma cells produce antibodies to form antigen-antibody complexes. In general, it takes about one week from the initial infection until the above immune response is established.

In addition, when the same antibody described above is first infected in the human body and the antigen has invaded the human body for the second time, the immune memory is established. Plasma cells produce antibodies and form antigen-antibody complexes.

Furthermore, the plasma cells that have memorized immunity described above may forget their immune memory over time. This is the tolerance of immune memory.

Further, as described above, when an antigen such as a malaria parasite or influenza virus that has entered the human body enters the human body, the human body acquires immune memory in approximately seven days. The human body acquires immune memory and plasma cells produce antibodies, forming an antigen-antibody complex, and the human body uses antigens such as malaria parasites or influenza viruses that have invaded the human body. Destroying or killing.

In conclusion (1), as explained above, in the case of an initial infection in which an antigen such as a malaria parasite or influenza virus has entered the human body as an antigen in the human body, it takes approximately 7 days. The human body acquires immune memory. This means that, for example, in the case of the first infection in which an antigen such as a malaria parasite or influenza virus has entered the human body,
The malaria parasite that has invaded the human body for approximately one week until the human body acquires immune memory, or the malaria parasite if the growth of antigens such as influenza virus is suppressed or killed by drugs, etc., or Since the autoimmunity of the human body reduces the growth of influenza viruses and other malaria parasites, or the growth of influenza viruses and the like, the progression of the disease state stops.

As a conclusion (2), the human body acquires immune memory in about 7 days as explained above. Here, we asked Associate Prof. Akira Ishii of Hamamatsu Medical University shown in Table 10 for experimental results of infecting mice with malaria parasites, as shown in Fig. 4 and Fig. 5, at Kyushu Health and Welfare University. According to the result of infecting mice with influenza virus, which was requested by Prof. Masahiko Kurokawa, first of all, as shown in Table 10, experiments were conducted in which mice were invaded with the antigen malaria parasite or influenza virus. From the results, in the experimental results of invasion of malaria parasites, the mice survived for 18 days from the initial infection with each of the combined use of artesunate and catechin, or the combined use of chloroquine and catechin, so the mouse acquired immune memory. It would have survived until. In addition, as shown in FIGS. 4 and 5, the results of an experiment in which an influenza virus, which is an antigen, was invaded into mice, showed that both catechins polyphenone 70S and sunphenon BG-3 were each 8 days after the initial infection. It is an experimental result in which it can be determined that the mouse has acquired immune memory when the weight increase / decrease of the mouse up to the eye is compared with the control. Furthermore, as shown in FIG. 5, it is an experimental result that it may be judged that the survival days have been extended by acquiring immune memory, particularly with respect to Sanphenon BG-3.

The conclusion (3) is that the human body survives for a period of approximately 7 days after the invasion of antigens such as Plasmodium or influenza virus into the living human body until the human body acquires immune memory. By using a drug for the purpose, by suppressing or killing the growth of antigens such as malaria parasites or influenza viruses that have invaded the human body, the human body can survive by the immune memory acquired by the human body. It will be possible. In short, antibodies are produced in a period of about 7 days after the antigen enters the human body. This is approximately 7
If the human body is allowed to survive for a period of days, the human body can survive by autoimmunity.

In addition, treatment of athlete's foot which develops mainly due to vesicular ringworm fungus, which can be formed on the toes of the human body, toes, toes, or toes by using electromagnetic waves. As a means, microwaves that are electromagnetic waves within a range that does not affect the human body, for example, the above-described Examples 1, 2, 3,
Using the magnetron oscillator, which is an improved household microwave oven described in 4, 5, 6, and 7, for example, a 500 W microwave is applied for about 20 seconds, about once every 10 minutes. Periodically, microwaves are applied to the affected part such as the toes of the human body, the toes of the human body, the toes of the hands, or the toes of the hands, and parasitic on the horny layer inside the skin Using the electromagnetic waves that are microwaves, the bacteria, fungi, and the wings are
For example, the stratum corneum is heated to a temperature of around 65 ° C using a 500 W microwave, and the heating time is about 20 seconds, and a 500 W microwave is irradiated for about 20 seconds to form athlete's foot. protein,
To denature and decompose chain sugars and lipids by microwave heating for a very short time to selectively kill only athlete's foot without affecting the skin and stratum corneum that make up the human body. It has been found that the use of microwaves can effectively kill and kill athlete's foot.

Furthermore, an aqueous solution in which catechin is dissolved in sterilized pure water (hereinafter abbreviated as an aqueous solution) in which catechin is purified as described above, an aqueous solution in which catechin is dissolved, Or by vein, or subcutaneous, arterial injection, intravenous injection, or subcutaneous injection,
Influenza virus such as highly toxic H5N1 or HIV virus that causes AIDS, or hepatitis virus, or HPV present in the blood of the human body or in the body
Viruses, or rotaviruses, or noroviruses, or sapoviruses, or adenoviruses, or astroviruses, or herpes viruses, or other miscellaneous viruses, or MRSA
Infectious diseases caused by various kinds of viruses can be treated by inactivating or killing bacteria such as O157 in the blood or in the human body. To do. Food raw materials, foods, health foods, drinking water, drinking water characterized by treating diseases caused by MRSA or O157, bacteria such as vaginal clamia, or ringworms such as athlete's foot Raw materials, alcoholic beverages, shochu raw materials, tea bag raw materials, tea bags, feed raw materials, feed, fertilizer raw materials, fertilizers, organic fertilizers, pharmaceutical raw materials, pharmaceuticals,
Alcohol raw materials, cosmetic raw materials, cosmetics, sanitary medicinal napkins, sanitary medicinal tampons,
Women's medicinal napkins, women's medicinal tampons, men's napkins, men's medicinal napkins, baby medicinal urines, elderly medicinal urines, and methods for producing the same.

In addition, as described above, catechin, or glycyrrhizin extracted from licorice which is a Chinese medicine, or chemically synthesized glycyrrhizin (hereinafter abbreviated as catechin),
About 80% of the causes of vomiting and diarrheal vomiting and diarrhea are said to be caused by rotavirus, especially in infants aged 4 months to 2 years of age. In developing countries, about 1 million infants die each year from acute gastroenteritis due to rotavirus. Other viruses that cause gastroenteritis include viruses such as sapovirus, norovirus, adenovirus, and astrovirus (hereinafter abbreviated as rotavirus). As a means of treating gastroenteritis caused by this rotavirus, an aqueous solution in which an active ingredient of catechin is dissolved, a tablet containing an active ingredient of catechin, or a powder of catechin containing an active ingredient of catechin is orally administered to an infant. It is possible to provide a therapeutic means for treating gastroenteritis by inactivating rotavirus which is the causative virus of gastroenteritis growing in the mucous membrane of the intestinal tract . In addition, catechins can be administered orally or used as nasal drops, so catechins have good permeability, so catechins administered orally or as nasal drops are absorbed into the blood by the intestinal tract, the digestive organ. Because it can be inactivated using catechins orally administered with viruses such as HTLV-1, which is the causative virus of adult leukemia that is present in the blood, it was intended for the treatment of adult leukemia The therapeutic means can be provided using catechin administered orally or as a nasal spray.

In addition, since catechins that have been orally administered with hepatitis-causing viruses such as HCV virus that grow in the liver can be inactivated, catechins that have been orally administered to treat hepatitis are used. It can be provided as a feature. In the intestinal tract where orally administered catechin is the digestive organ, catechin dissolved in blood is transported to cells on the surface of the bronchus and to cells on the surface of the lung, so that the bronchi that is the airway Oral administration of therapeutic means for the treatment of pneumonia and influenza because it can inactivate influenza viruses that grow on the surface of lungs or the surface of the lungs, or viruses that cause SARS, etc. It is characterized in that it can be provided using catechins.

In addition, since catechin administered orally can be used to kill tuberculosis bacteria growing in the bronchus and lungs of the respiratory tract, catechin administered orally with therapeutic means for the treatment of tuberculosis It can be used and provided. In addition, community-type MRSA that grows in blood using orally administered catechins, or bacteria that grow in blood, such as resistant MRSA, can be killed in blood. It is characterized in that it can be provided using orally administered catechins for the purpose of treating diseases caused by bacteria such as MRSA. Furthermore, catechin administered orally is absorbed or penetrated into the blood in the intestine, and cancer metastasis is killed by killing cancer cells existing in the blood or floating cancer cells. It is characterized in that it can be provided using orally administered catechins, which are therapeutic means for the purpose of treatment for suppression. In addition, neutral fats that are catechins dissolved in blood are fats present in the inner wall of blood vessels or blood,
Or, fats such as bad cholesterol and catechin bind to each other, and catechin has the effect of excreting fat as waste products outside the body. By excreting as waste products, it is possible to provide a therapeutic means having an effect of lowering blood pressure. As (2), since it has an effect of excreting fats in the body, it has the effect of preventing and reducing the weight of obesity prevention and obesity prevention. (3) As a means of treating diabetes by the effect of reducing lipids, which are fats in the body, by administering catechin orally, catechin is injected arterial, or catechin is instilled. It is possible to provide a therapeutic means that can be performed. (4) As for catechins that are orally administered catechins that are orally administered malaria parasites that cause malaria, caused by parasitism of malaria parasites mediated by mosquitoes, mosquitoes Or using catechin with arterial injection, or using catechin with infusion, malaria parasite skin, or lipid part which is a fat constituting malaria parasite, The present invention is characterized by providing a therapeutic means for treating catechin carboxyl groups electrically or chemically to kill malaria parasites in blood. (Five
As for the type of virus, the structure of more than 99% of about 30,000 types of viruses currently being found on the earth, including the HIV virus of AIDS patients,
The structure of the majority of viruses has tuberculosis as the center, an envelope that is an epidermal protein around the periphery of the nucleic acid, and an infectious adapter that invades host cells on the envelope surface. Viruses are more than 99% of the structure of the approximately 30,000 viruses currently discovered. The part that plays the most important role in the survival of this virus is the key when the virus invades host cells that are human cells,
Spikes, which are infection adapters that bind to the keyholes, are the most important part of the virus trooper. It is the key to the tip of the spike, which is the infection adapter that is the virus guard, and the keyhole is made of fat, a lipid. Due to the structure of this virus, the lipids made of fats at the tip of the spike, which is the most important infection adapter, and the carboxyl group of catechin are electrically or chemically copolymerized to produce virus. As described above, the structure made of epidermal protein around its periphery, centered on nucleic acids, as explained above, is currently found on the earth, about 30,000 types of more than 99% types. All viruses will be unable to enter the host cell.

Furthermore, as a result, the virus cannot survive and is killed and inactivated. In conclusion, if the virus is considered as an aliphatic lipid, catechins co-polymerize or condense with fatty lipids and the hydroxyl groups (OH groups) or carboxyl groups of catechins electrically or chemically. Strong nature. Since the hydroxyl group (OH group) or carboxyl group of catechin has a strong electrical or chemical bond strength, the properties of lipids that are electrically or chemically bound to catechins are The nature disappears. Exactly the same phenomenon is that catechins administered orally do not break down in the stomach, catechins pass through the stomach in the intestine, catechins are absorbed into the blood, or taken into the blood Spikes and catechin hydroxyl groups (OH groups), which are the causative agents of infectious diseases that develop with viruses such as HIV, HCV, and HTLV-1 that are present in the blood ), Or infectious diseases using orally administered catechins for the purpose of treatment to inactivate the virus causing the infection by electrically or chemically copolymerizing or condensing carboxyl groups Inactivate the virus causing the infection or inactivate the virus causing the infection by injecting intravenously, or inactivate the virus causing the infection by arterial injection of catechin, or infusion of the catechin Feeling Food raw material, food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tea bag raw material, tea, characterized by providing treatment means to inactivate the disease-causing virus Bag, feed raw material, feed, fertilizer raw material, fertilizer, organic fertilizer, pharmaceutical raw material, pharmaceutical, alcohol raw material, cosmetic raw material, cosmetics, sanitary medicinal napkin, sanitary medicinal tampon, feminine medicinal napkin, feminine medicinal tampon, for men Napkin, medicinal napkin for men, medicinal squeeze for infants, medicinal squeeze for elderly, and its manufacturing method, and rotary kiln, rotary kiln similar to rotary kiln, circular incinerator, soap, body soap, hair shampoo, hair rinse, and apparatus thereof .

In addition, as described above, the disease name is malaria. Malaria is a disease caused by malaria parasites mediated by anopheles mosquitoes that live in the tropics centered on the equator. Malaria is unique to the tropics. It is a disease mediated by anopheles mosquitoes, and more than 1.5 million people die each year. Death from AIDS virus is an artificial illness and can be prevented without sexual activity. Malaria is killing the most lives on the planet, and malaria is the first death rank. The second most common cause of death is rotavirus, sapovirus, norovirus, adenovirus, and astrovirus (hereinafter abbreviated), which causes vomiting and diarrhea in infants and children with the second highest death rate. In the developing countries, about 1 million infants and children develop in the developing country due to rotavirus that grows in the intestinal mucosa in 1 year. Is said to have died of acute gastroenteritis. The present invention provides a therapeutic means for treating acute gastroenteritis caused by malaria with the first rank of death and rotavirus with the second rank of death on the earth using catechins. Objective. Now, malaria refers to sporozoites → cryptozoites → merozoites → hypnozoites → hemozoites collectively as malaria parasites, as described below as life of malaria parasites. Malaria is the name of the disease caused by the parasite mosquito being transmitted to the human body by the mosquito, and the malaria parasite parasitizing the human body.

Furthermore, the experimental results of inactivating influenza virus using catechin, which was joint research with Prof. Masahiko Kurokawa of Kyushu University of Health and Welfare explained in (0215) above,
Posted to ture Medicine. The English manuscript of the content of the submission is listed below.

Nature
The content of the English text submitted to Medicine is an English translation of the report of the experimental results from Professor Masahiko Kurokawa on February 21, 2009, explained in (0216) above. Is the same content as the report of the experimental results, so we will omit the Japanese translations of the following English content.

Activation
experiment of anti-influenza virus by catechins

Tomomi Shimizu1, Eri
Sawamura1, Masahiko Kurokawa 1, Kumiko Nagaura 2, Zen-ichir
o Nagaura 2, Yoshhiaki
Nagaura 2
1 Department of
Biochemistry, School of Pharmaceutical Sciences, Kyushu Universi
ty of Health and Welfare,
1714-1 Yoshino, Nobeoka, Miyazaki, 882-8508, Japan
2 Nagaura Lab., Inc.,
4-32-104, Yumachi 3-chome, Chikushino-City, FukuokaPref.,
Japan
Correspondence should be
addressed to Yoshiaki Nagaura
1306281492281_0.jp

Influenzavirus
infection model in mice was used to examine the anti-influenza v
irus efficacy of
catechins (Sunphenon BG-3 (BG-3) and Polyphenon 70S (70S)). Im
mediately after the
catechins at 50 mg / kg were intraperitonealy given once to mi
ce, they were intranasally
infected with influenza virus PR8 strain at 500 PFU / m
ouse. Further the
catechins were intraperitonealy injected twice per a day duri
ng 5 days .. The weight
decrease of infected mice was significantly supressed by
BG-3 catechin as well as
Tamiful at 1mg / kg. In the case of 70S catechin, the w
eight loss was also
suppressed after 4 days post-infection although there was no
significant.
70S catechin seemed to postphone the mean survival times of infec
ted mice compared with
control but BG-3 catechin did not.BG3 and 70S catechins
contain the
different ratios of catekin molecules. Thus, it is possible that s
ome types of catekin
molecules including BG3 and 70S with different ratios show
anti-influenza virus
efficacy in mice.

Influenza is an
1306281492281_1
that affects
1306281492281_2
and
1306281492281_3
caused by
1306281492281_4
of the influenza
viruses1). In humans, common symptoms of the disease are
1306281492281_5
,
1306281492281_6
,
1306281492281_7
, severe
1306281492281_8
and
1306281492281_9
In more serious cases,
influenza
1306281492281_10
1306281492281_11
, which can be fatal,
particularly in young children and the elderly.
influenza is
transmitted from infected mammals through the air by coughs or sne
ezes, creating
1306281492281_12
containing the
virus, and from infected birds through their
1306281492281_13
. Flu viruses can remain
infectious for about one week at human body temperature
, over 30 days at 0
1306281492281_14
, and for much longer
periods at very low temperatures.Flu spreads around the w
orld in
1306281492281_15

1306281492281_16
, resulting in the deaths
of hundreds of thousands annually, millions in
1306281492281_17
years. A deadly
avian strain named
1306281492281_18
has posed the greatest
risk for a new
1306281492281_19
The most common human
vaccine is the trivalent
1306281492281_20
that contains
purified and inactivated material from three viral strains.

The human body can
get antiviral immunition typicaly in a week against the infl
uenza, malaria, herpes and
so on2). Tamiflu is the brand name for a drug known a
s
1306281492281_21.asp? Articlekey = 11941
, one of a class of
1306281492281_22.asp? Articlekey = 10211
drugs that can
reduce the severity of flu symptoms. Tamiflu is blocking the act
ion of an enzyme called
neuraminidase that helps cells infected with the influen
za virus spread the
infection to healthy cells. Tamiflu reduces the severity of
symptoms and the duration
of an influenza virus infection.

Ithas been reported
that green tea consumption reduces the risk of coronary art
ery disease and cardiac
events. The catechin is a major constituent of Japanese
green tea and an
antioxidant. Catechins are extracted from green tea leaves, whi
ch catechins have also
been shown to possess antibiotic properties due to their
role in disrupting a
specific stage of the bacterial DNA replication process.Ox
idative stress was lowered
in cell mitochondria, as well as increase in mRNA tra
nscription of mitochondria
related proteins. The tea polyphenol may be commercia
lly available products,
for example, those which contain catechins as a major in
gredient, such as trade
name Polyphenon 70S (manufactured by Mitsui Norin Co., L
td. in Tokyo), which tea
polyphenol content: 70% or more. Sunphenon BG-3 is supp
lied by Taiyo Kagaku Co.
Ltd, and contains polyphenol more than 80% and caffein
less than 1%.
Catechins have been reported to have a suppressing effect on an
increase in cholesterol
level and an inhibitory effect on α-amylase activity. T
able 1 shows the catechin
component of Polyphenon 70S and Sunphenon BG-3. Epigal
locatechin gallate (EGCg)
is the ester of
1306281492281_23
and
1306281492281_24
and a type of
1306281492281_25
EGCg is the most abundant
catechin in
1306281492281_26
, and this may have
therapeutic properties for many disorders including cancer.

In this brief
communication, influenza infection model through the mouse nose i
s experimentented for
activation of anti-influenza virus by catechins as seen in
Table 2.
Intraperitoneal (IP) injection is the injection of a substance into th
e
1306281492281_27
(body cavity). IP
injection is more often applied to animals than humans.
generally preferred
when large amounts of blood replacement fluids are needed,
or when low blood pressure
or other problems prevent the use of a suitable blood
vessel for
1306281492281_28
. In mice, IP injection is
predominantly used in veterinary medicine for the adm
inistration of systemic
drugs and fluids due to the ease of administration compa
red with other parenteral
methods.

Asshown in Figure 4,
the new treatment was executed by Sunphenon BG-3 and Polyp
henon 70S. Immediately
after the 0.2 ml catechin as 50 mg / kg was given once to t
he mouse on Jan. 24, 2008,
it was infected as plaque forming units 500 PFU / mouce
by influenza virus stem
(H1N1 viruses PR8) which had been breeded in Mardin-Darb
y canine kidney (MDCK)
cells, and the catechin was injected twice per a day duri
ng 5 days to the body
cavity of female non-infected mouse BALB / 0, which was 6 we
eks old and 20-22 g
weight. As shown in Figure 1, the weight decrease was supres
sed apparently during 7
days after the injection of 70S, and it was even recover
ed during 4 days after the
injection of 70S. optionally, the injection of BG-3
eased the weight decrease
after 4 days. The Tamiflu injection of 1mg / kg as 0.2
ml supressed the
weight decrease during one week.However the weight decrese w
as not prevented by both
tamiful and two catechins injection.

As seen in Figure 5,
the survival rate of mouse was observed until 7 days after
the catechine
injection end to study the anti-influenza virus activation only w
ith catechins. A p-value
of an experiment is a random variable defined over the
1306281492281_29
of the experiment such
that its distribution under the null hypothesis is unifor
m on the interval (0,1).
The survival rate was approximately 83% up to a week a
fter the injection of
catechine BG-3. Also the survival rate was nearly 66% one
week after the
injection of catechine 70S. The control case without any treatme
nt showed around 50%
The mouse weight change and the life span w
ere observed until 10 days
after the catechine injection end in order to study t
he anti-influenza virus
activation only with catechins.
Two catechins as 70S and
BG-3 were found to be effective for mice as antiviral t
reatment of influenza to
prevent their weight loss. These samples of lean catech
ins as 500mg / ml are
possible to be injected into the vein, since they could flow
through the filter.
Further experiments are undertaken to show the effect of in
jection method and the
amount for the body absorption efficiency.

References
1. Morse, Stephan S., The
US pandemic influenza implementation plan at six month
s,
Nature Medicine 13, pp.681
-684, June1 2007.
2. Shiraki, K. etal.,
Mechanism of Action of T-705 against Influenza Virus, Antim
icrobial Agents and
Chemotherapy, pp. 981-986, Vol. 49, No. 3, March 2005.

In addition, catechin alone or catechin and chloroquine jointly researched with associate professor Akira Ishii of Hamamatsu Medical University, which was reported in English and a Japanese translation in English, as of May 11, 2009. The results of the experiment on antimalarial effects in combination with catechin and artesunate were explained in (0250) above, and the results of anti-influenza virus experiments reported in English were also submitted to Nature Medicine. . The English manuscript of the posted content and the Japanese translation of the English manuscript are listed below.

Main user
From: "Akira Ishii"
(
1306281492281_30.jp
)
To: (
1306281492281_31.jp
)
Sent: Monday, May 11, 2009
2:32 PM
Subject: Experimental results

Mr. Yoshiaki Nagaura The days that remind you of summer continue, how are you?
We will send the result of your request by fax.

Experiment 1 is the number of days survived (shown in Figure 7 and the protozoan growth pattern is shown in Figures 8 and 9).

Experiment 2 is growth inhibition (already sent as Table 15)
As described in the report, two types of experiments were conducted. In Experiment 1, the result that life-prolonging effect was seen when combined with chloroquine was obtained, but since the number of mice used was small, no statistically significant difference was observed. However, if the one that died on the 7th day in the CQ + (BG-3) group is excluded, a significant difference will be given by (Kruskal-Wallis test). If you add experiments and increase the number of animals, the Q + 70s group will be able to withstand statistical processing.

In Experiment 1, the catechin's harmful effects appeared, and we could not study the combined use effect with Artesunate. This result shows that protozoan growth was further suppressed by the combined use.

I think the English text of the result is the one you sent and there is no problem.
In addition, contact by fax is likely to cause inconvenience to the other party (fax user), so please contact us by e-mail in the future.
Well, then, I'm looking forward to working with you.
Hamamatsu Medical School Infectious Diseases Akira Ishii

Efficacy of
catechins in combination with commonly used antimalarial drugs, chl
oroquine and artesunate,
in Plasmodium berghei NK65-infected mice

Akira Ishih1,
Francis W. Muregi1, Kumiko Nagaura2, ZenichiroNagaura2,
Yoshiaki Nagaura2
1 Department of Infectious
diseases
Hamamatsu University
School of medicine
1-20-1 Handayama,
Higashi-ku, Hamamatsu 431-3192, Japan
2 Nagaura Lab., Inc.,
4-32-104, Yumachi 3-chome, Chikushino-City, Fukuoka Pref.,
Japan
Correspondence should be
addressed to Yoshiaki Nagaura
1306281492281_32.jp

Effects of
catechins, SunphenonBG-3 (BG-3) and polyphenon70S (70S), alone or in c
ombination with
chloroquine (CQ) or artesunate (ART) were evaluated against a bl
ood-induced infection with
CQ-tolerant Plasmodium berghei NK65 in mice.

Handling of animals
was done in accordance to the Guide for the Care and Use of
Laboratory Animals,
Hamamatsu University School of Medicine.

Experiment 1: Male
ICR mice were inoculated intraperitoneally with 1x105P. Berg
hei NK65-parasitized
erythrocytes, and were randomized into groups of 4 mice eac
h. The infected mice were
orally treated once a day for three consecutive days w
ith CQ at a dose of 20 mg
base / kg from day 4 and 13 pi, with or without cateki
ns intraperitoneally; BG-3
and 70S, 50 mg / kg twice a day for 3 days. Oral dose o
f 2 mg / kg of ART was given
to mice twice a day for 3 days from day 4 pi, with
or without catekins
intraperitoneally.From day 4, Giemsa-stained thin blood sme
ars from tail vein blood
were used to assess parasitemia. An equivalent volume o
f distilled water was
given orally to mice in the untreated, infected.

Experiment 2: Female
BALB / c mice were inoculated intraperitoneally with 1x105P.
berghei
NK65-parasitized erythrocytes. The infected mice were orally treated tw
ice a day for three
consecutive days with ART at a dose of 2 mg / kg twice a day f
rom day 4 pi, with or
without catekins intraperitoneally; BG-3 and 70S, 25 mg /
kg once a day for 3 days.

The results of
experiment 1 are shown in Figs.The infected mice in an untreate
d control group showed a
progressively increasing parasitemia leading to mouse d
eath (from day 8 to 10)
(Fig. 1). A three-day dosage of 20 mg base / kg of CQ alon
e from day 4 and 13 pi
produced a mild effect against the infection, and all m
ice died from day 14 to 19
with an increasing parasitemia.On the other hand, in
fected mice treated with
CQ plus catekins survived longer than the CQ alone grou
p. One of 4 mice treated
with CQ and BG-3 and 70S died at day 7 or 15 pi, resp
ectively, which death
might be caused by adverse effects of catekins.It is note
worthy that the
parasitemia levels just before death in the combination groups w
ere higher than those of
CQ alone group (Fig. 2). Suppression of cytokins produc
tion, such as IFN-gamma
may have resulted in greater parasitemia.In the studies
regarding ART, there
was no obvious combination efficacy of catekins (Figs. 1 a
nd 3).

The results of experiment
2 are shown in table 1. Combination efficacy was measu
red by percentage (%)
parasitemia suppression at day 7 pi relative to the ART
only treated group. For
comparison of average parasitemia at day 4 and 7 pi, o
ne-way ANOVA and 2-tailed
Student's t-test were used, with p <0.05 being conside
red significant. There was
no adverse effect of catekins at dose of 25 mg / kg onc
ea day for 3 days. It is
remarkable that the combination groups had shown signi
ficant parasitemia suppression.

The present results
indicate that the combination of CQ and ART with catekins ex
tends the clinical utility
of catekins, but further study is necessary to determ
ine the mechanisms
contributing to the enhancement of CQ or ART effects.
Brief explanation of
figures:

Fig.7.
Time-course changes of survival rate of mice in response to treatment.
P. berghei NK65- infected
mice were orally treated once a day for three consecut
ive days with chloroquine
at a dose of 20 mg base / kg from day 4 and 13 pi, wit
h or without catekins
intraperitoneally; BG-3 and 70S, 50 mg / kg twice a day for
3 days. Oral dose of 2
mg / kg of artesunate was given to mice twice a day for 3 d
ays from day 4 pi, with
or without catekins.

Fig.8.
Parasitemia profile in the bloodstream of P. berghei NK65- infected mic
e orally treated once a
day for three consecutive days with chloroquine at a dos
e of 20 mg base / kg from
day 4 and 13 pi, with or without catekins intraperiton
eally; BG-3 and 70S, 50
mg / kg twice a day for 3 days.

Fig.9. Parasitemia
profile in the bloodstream of P. berghei NK65- infected mice
orally treated twice
a day for three consecutive days with artesunate at a dose
of 2 mg / kg from day
4 pi, with or without catekins intraperitoneally; BG-3 an
d 70S, 50 mg / kg twice a
day for 3 days.

TabelTable 15:
Parasitemia suppression (%) on day 7 post infection (pi) for m
ice treated with
artesunate and in combination with BG-3 and 70S, respectively.

From day 4 after
injection, mice were given artesunate orally at a dose of 2 mg
/ kg b.wt.twice a day for 3
days, and then, except for mice in the artesunate-med
iated group, the remaining
mice were further given the following drugs; BG-3 or 7
0S at 25 mg / kg b.wt.From
day 4 after injection, mice were given artesunate orall
y at a dose of 2 mg / kg
b.wt.twice a day for 3 days, and then, except for mice in
the
artesunate-mediated group, the remaining mice were further given the followi
ng drugs; BG-3 or 70S at
25 mg / kg b.wt.intraperitoneally once a day for 3 days.
An equivalent volume of
distiled water was given orally to the mice in the infec
ted control.

Statisticaly
non-significant values on day 4 pia Significantly different from
the value of the
artesunate-treated mice
(Student's t-test,
p <0.05)

In addition, the Japanese translation of the content of the English text submitted to Nature Medicine regarding the anti-malarial effect described above, with regard to the anti-malarial effect of catechin alone, catechin and chloroquine, or catechin and artesunate is given below. Make a description.

Combined effects of catechins and antimalarial drugs, chloroquine and artesunate in mice infected with the murine malaria parasite Plasmodium berghei NK65

Catechin, sanphenone BG-3 (BG-3) and polyphenone 70S (70S) alone against CQ-resistant murine malaria parasite infection or chloroquine (CQ) or artesunate (
The combined effect with ART) was examined.

  The animal experiment plan was conducted according to the animal experiment guidelines of Hamamatsu Medical University.

Experiment 1: 100,000 I. protozoa-infected erythrocytes were intraperitoneally administered to male ICR mice and divided into groups of 4 individuals. CQ was orally administered once daily for 3 consecutive days from the 4th and 13th day of infection. A
RT was orally administered at a rate of 2 mg / kg body weight twice daily for 3 consecutive days from the 4th day of infection. Further, in the catechin combination group, 50 mg / kg body weight was administered intraperitoneally twice a day. Untreated mice were orally administered an equivalent amount of distilled water. From the fourth day of infection, Giemsa staining was performed on blood smears prepared from the tails of mice, and the bloodworm rate was measured.
Experiment 2: 100,000 protozoa-infected erythrocytes were intraperitoneally administered to female BALB / c mice. 3 days from infection 4
ART was orally administered at a rate of 2 mg / kg body weight twice a day for consecutive days. Furthermore, in the catechin combination group, 25 mg / kg body weight was intraperitoneally administered once a day. Untreated mice were orally administered an equivalent amount of distilled water. From the fourth day of infection, Giemsa staining was performed on blood smears prepared from the tails of mice, and the bloodworm rate was measured.

The results of Experiment 1 are shown in FIG. 7, FIG. 8, and FIG. Infected mice in the untreated control group showed an increase in malaria parasites and all mice died 8-10 days after infection (FIG. 7). 20 of CQ
Administration of mg / kg for 3 days showed a moderate effect on infection, but with an increase in the bloodworm rate, all mice died 14 to 19 days after infection. On the other hand, the mice in the CQ and catechin combination group survived longer than the mice in the CQ single administration group. The death of one animal each in the combination group of BG-3 and 70S seems to be a side effect of catechin. It should be noted that the rate of bloodworms immediately before death of mice that died in the combination group was higher than that of the CQ alone group (FIG. 8). Suppression of production of cytokines such as IFN-γ may lead to a high bloodworm rate. In Experiment 1, no obvious combined effect of ART and catechins was observed (FIGS. 7 and 9).
The results of Experiment 2 are shown in Table 15. The combined effect of catechins was evaluated by suppression of protozoan growth in the combined group with respect to the ART single administration group on day 7 after infection. Intraperitoneal administration of catechins at a daily dose of 25 mg / kg body weight showed no side effects. The combination group showed significant protozoan growth inhibition.

The results of this experiment suggest that the combined use of CQ, ART, and catechins suggests the possibility of clinical application of catechins. Research is needed.

In addition, for example, an influenza virus such as the highly toxic H5N1 virus, or the HIV virus that is the cause of AIDS, or hepatitis virus, or HPV virus, or rotavirus, or norovirus, sapovirus, or adenovirus, or astrovirus Various viruses such as viruses or herpes viruses, or bacteria such as MRSA or O157 in the blood or in the body of the human body by inactivating the virus or killing the bacteria Infectious disease (hereinafter referred to as “infection” for short) or AIDS virus (HIV), hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV)
), Infectious diseases such as influenza virus, Mycobacterium tuberculosis, or cancer cells (hereinafter abbreviated as infectious diseases), AIDS virus (HIV), hepatitis C virus (HCV), papilloma virus (HPV), vagina Infectious diseases (hereinafter abbreviated as infectious diseases) infected by sexual acts such as chlamydia and syphilis, or malaria, influenza, dengue fever, Japanese encephalitis, yellow fever,
And sleepiness (hereinafter abbreviated as infectious disease), malaria parasite, trypanosoma protozoa, Costaria schistosomiasis, and rat contracted nematode (hereinafter abbreviated as infectious disease), or MRSA
Or, O157, or bacteria such as vaginal chlamydia, or athlete's foot, or the disease that develops due to ringworm fungi such as rice worms (hereinafter referred to as infectious disease for short), explained above, Epigallocatechin (EGC), epicatechin (EC), gallocatechin (GC), various infectious diseases
Catechin (C), epigallocatechin gallate (EGCg), epicatechin gallate (ECg), gallocatechin gallate (GCg), and catechin gallate (Cg) are each a single catechin or a catechin mixed with the above 8 types of catechins ( Infection in which blood is infected by intravenous administration, intramuscular administration, intraperitoneal administration, and intravenous administration (hereinafter, abbreviated intravenous administration). The purpose is to treat the disease.

Furthermore, when catechin is administered intravenously as described above, it is necessary to pass through a 0.45 μm filter made of PTFE or PVDF, so the following (1), (2), (3 ), (4), (5)
There are conditions as described in (6) and (7).

As the condition of (1), (Table 6) of (0053), (0054), (0055) (Table 7)
) And (0056) As described in (0056), various catechins that do not contain caffeine at 0% or less, or catechins are administered intravenously as a means of treating infectious diseases. Treatment of infectious diseases.

As a condition of (2), the content of caffeine is 1.0% or less, or 2.5% or less, or 5.0% or less, or 5.4% or less, or 10.0% or less, or 15% with respect to the total weight of various catechins. Less than or 20%
The following catechins containing caffeine, or catechins, are used as a means for treating infectious diseases and administered intravenously to treat infectious diseases.

The condition of (3) is that when various catechins or catechins are intravenously administered into a living body such as a human body and an animal (hereinafter, abbreviated as a living body) to treat infections, 500 mg or less, or 250 mg or less, or 125 mg or less, or 100 mg or less, or 50 mg or less, or 25 mg or less, or 10 mg or less, or 5 mg or less, or 2.5 mg or less, or 1.0 mg per kg of the total weight of The following various catechins or catechins are used as a means for treating infectious diseases and administered intravenously to treat the infectious diseases.

As the condition of (4), as shown in (Table 4) of (0051), the sunphenone EGCg described in (Table 2) of (0049) is a PTFE or PVDF 0. It cannot pass through a 45 μm filter. The reason is that the solubility of epicacatechin gallate (EGCg) shown in the example of analysis value of sunphenone EGCg described in (Table 2) of (0049) is so high as 92.7%. It is. Therefore, in order to increase the solubility of catechin and improve the permeability of the filter, the content of epicacatechin gallate (EGCg) with respect to the total catechin content was analyzed for polyphenone 70S in (0048) (Table 1). As shown in the value example, it should be 32.2% or less. Alternatively, it is set to 41.7% or less shown in the analysis value example of sunphenon BG-3 in (Table 5) of (0052). Alternatively, the content of epigallocatechin gallate (EGCg) with respect to the total catechin content is 50% or less. Alternatively, the content of epigallocatechin gallate (EGCg) is 60% or less. Alternatively, the content of epigallocatechin gallate (EGCg) is 70% or less.
Alternatively, the content of epigallocatechin gallate (EGCg) is 80% or less. Alternatively, by setting the content of epigallocatechin gallate (EGCg) to 90% or less, the solubility of catechin in physiological saline (water for injection) is high, and a 0.45 μm filter made of PTFE or PVDF is used. There is a need to use catechins with good permeability as a therapeutic means for the treatment of infectious diseases.

The condition of (5) is that when the content of epigallocatechin gallate (EGCg) is large relative to the total weight of catechin and the solubility in water for injection is poor, dimethyloxide (hereinafter abbreviated). , GMSO) 0.5% or less, 1.0% or less, or 1.5% or less, or 2.0% or less, or 2.5%
Or less, or 3.0% or less, or 3.5% or less, or 4.0% or less, or 4.5% or less, or 5.0% or less, or
When using a saline solution (water for injection) containing 6.0% or less, or 7.0% or less, or 8.0% or less, or 9.0% or less, or 10.0% or less, or a very small amount of methanol, epigallocatechin gallate ( The solubility of EGCg) became high, and intravenous administration became possible due to the good permeability of 0.45 μm filter made of PTFE or PVDF.

As for the condition of (6), in the case of epigallocatechin gallate (EGCg) which is a new compound by introducing fatty acid into epigallocatechin gallate (EGCg) using enzyme lipase, it was explained above. In the same manner as described in the condition of (5), dimethyloxide is 0.5% or less, or 1.0% or less, or 1.5% or less, or 2.0% or less, or 2.5% or less, or 3.0% or less, or 3.5%
Or less, or 4.0% or less, or 4.5% or less, or 5.0% or less, or 6.0% or less, or 7.0% or less, or
8.0% or less, or 9.0% or less, or 10.0% or less, or using physiological saline (water for injection) mixed with a very small amount of methanol, the solubility becomes high, and PTFE or PVDF 0.45μm The filter has good passability.

The conditions of (7) include an aqueous solution obtained by extracting hot water using an aqueous solution from tea leaves and trunks (hereinafter referred to as tea leaves for short), or sodium bicarbonate or sodium carbonate in the aqueous solution. For example, by removing caffeine as much as possible from the inside of the tea leaf components contained in the aqueous solution extracted with alkaline hot water using an alkaline aqueous solution with a PH concentration of around 8.5, for example, , The content of caffeine is 0%, or 1% or less, or 2.5% or less,
Or freeze-dry for the purpose of concentrating the extract from tea leaves of 5% or less, or 10% or less,
Also included is tea leaves that are extracted from tea leaves, which are prepared by dissolving fine powders made from tea leaves concentrated by spray drying or other means as raw materials, in physiological saline (water for injection). Epicatechin (hereinafter abbreviated as EC), epigallocatechin (hereinafter abbreviated as EC), or the case where the caffeine containing only caffeine is removed. , Abbreviated as EGC), epicatechin gallate (hereinafter abbreviated as Ecg), epigallocatechin gallate (hereinafter abbreviated as EGCg), catechin (hereinafter abbreviated as C), Gallocatechin (hereinafter abbreviated as GC), catechin gallate (hereinafter referred to as GC)
10 types of the above-mentioned active ingredients, which are contained in tea leaves such as abbreviated as Cg), gallocatechin gallate (hereinafter abbreviated as GCg), epicatechin (EC), and Strictinin, and the above All the active ingredients contained in the tea leaves other than the 10 types of tea were extracted from the tea leaves,
All active ingredients contained in tea leaves are influenza virus, HIV, HAV, HBV, HCV,
HPV, HTLV-1, or other viruses, or bacteria such as O157, Mycobacterium tuberculosis, or vaginal chlamydia, or protozoa such as trypanosoma protozoa, malaria protozoa, or syphilis (hereinafter referred to as infectious diseases for short) in the blood A therapeutic means for treating a human body by intravenous administration for the purpose of inactivation or death. Evaluation was based on suppression of protozoan growth in the combination group relative to the single administration group. Intraperitoneal administration of catechins at a daily dose of 25 mg / kg body weight showed no side effects. The combination group showed significant protozoan growth inhibition.

The results of this experiment suggest that the combined use of CQ, ART, and catechins suggests the possibility of clinical application of catechins. Research is needed.

However, when using chloroquine and catechin, which are the above experimental results, and artesunate and catechin together, the effect as a drug is doubled compared to using chloroquine alone and artesunate alone. It was found that the following reasons (1), (2), and (3) are possible.

The reason for (1) is that when Chloroquine (CQ) and catechin or Artesunate (ART) and catechin are used together in the human body, catechin is characterized by iron content (
(Hereinafter abbreviated as Fe) is a substance that easily causes a chemical reaction with red blood cells.
In Fe, catechin suppresses the action of Fe inside erythrocytes, and malaria parasite becomes unable to grow inside erythrocytes, or by suppressing the growth of malaria protozoa, CQ
When taken in combination with catechin or ART and catechin, the sensitivity of CQ or ART increases and the sensitivity doubles.

The reason for (2) is that if the above phenomenon is true, the name of the disease is a discovery of a major revolution as a means of treating malaria.
The fact that catechin easily causes a chemical reaction with Fe is a fact known to children, so the above may be considered a fact.

The reason for (3) is that chloroquine and catechin, artesunate and catechin undergo a condensation reaction to form a chloroquine derivative and an artesunate derivative. , Increased sensitivity to resistant malaria parasites.

The reason for (4) is that, for the same reason as described in (1), the protein called hem in the erythrocyte, or iron (Fe) in the erythrocyte and catechin bind to each other, thereby being sensitive to resistant malaria parasites. Becomes higher.

The reason for (5) is that the phenomenon described in (2), (3) and (4) described above is combined with the phenomenon of (1) by using chloroquine and catechin and artesunate and catechin together. Since the phenomenon of 3) and the phenomenon of (4) are caused by catechin intervening at the same time, the sensitivity to resistant Plasmodium increases.

If the above views (1), (2), (3), (4) and (5) are correct, there is a possibility of a great discovery.
The reason for this is that it is a specific medicine for the treatment of tuberculosis patients who have been researched and developed in the past because resistant tuberculosis has become available. This is because there is a possibility of changing to another compound called a streptomycin derivative to become a drug effective against resistant M. tuberculosis.

Furthermore, the conventional quinine, chloroquine, and artesunate, each of which is a specific medicine for malaria, as described above, are combined with catechin or fine powder of tea leaves to give resistant quinine, resistant chloroquine, The reason for increasing the sensitivity of quinine, chloroquine, and artesunate, which is less sensitive to resistant malaria parasites by avoiding resistant artesunate, is the iron content (Fe) in the erythrocytes where resistant malaria parasites grow
The chemical reaction between catechin and catechin prevents the resistant malaria parasite from growing inside the red blood cells, or the growth of the resistant malaria parasite inside the red blood cells is suppressed. This is the reason why the susceptibility of a specific drug to a malaria parasite can be increased by using each of quinine, chloroquine, and artesunate together with catechin or fine powder of tea leaves.

In addition, for the reasons explained above, it should be used in combination with catechins or fine powder of tea leaves, even if it is a specific drug that will be developed or planned to be developed as a specific drug for malaria. This means that the sensitivity can be further increased.

In addition, Prof. Arisa Wataya from the Faculty of Pharmaceutical Sciences at Okayama University is developing a specific medicine for resistant malaria parasites.
There is a specific medicine for the resistant malaria parasite named N251. N251 has emerged as a drug discovery defect because it is less effective against resistant malaria parasites, so when N251 is used as a medicine, it is necessary to take a large dose as an internal medicine. There are drawbacks to N251. N251 has a weak effect as a pharmaceutical against resistant malaria parasite
In order to increase the sensitivity of N251, taking N251 in combination with catechin or fine powder of tea leaves can increase the sensitivity of N251, so the dose of N251 can be reduced and halved As a result, N251 can be developed as a pharmaceutical product.

Furthermore, as described above, the catechin and chloroquine complex in which catechin and chloroquine are mixed, or the catechin and artesunate complex in which catechin and artesunate are mixed, or the catechin and N251 complex includes Although it is easily degraded in the small intestine, which is a digestive organ, it is not efficiently absorbed into the body, but a mixture of catechin and chloroquine mixed with catechin and chloroquine, or mixed with catechin and artesunate Since the complex of catechin and artesunate, or the complex of catechin and N251 is stable as a compound, it is difficult to be decomposed in the small intestine, which is the digestive organ,
Since it is possible to develop a therapeutic drug for oral administration in the form of tablets, powders, and syrups, the following (1), (2), (3), (4), and (5) There are advantages like

The advantage of (1) is that as a means of treating Nagana disease in which livestock such as cattle, horses, and goats that are livestock are infected by Trypanosoma protozoa infecting livestock such as cattle, horses, and goats, Nagana disease Oral administration to livestock such as cattle, horses and goats by mixing therapeutics intended for the treatment of Nagana disease in the feed given to livestock such as cattle, horses and goats Because it is possible to administer the drug, comparing intravenous administration by injection and oral administration,
By developing therapeutics intended for oral administration of tablets, powders, and syrups,
There is an advantage that treatment of Nagana disease becomes easy. The reason for this is that even though it is theoretically possible to administer intravenous drugs by injection to domestic animals such as cattle, horses, and goats,
Actually, livestock such as cows, horses, and goats are rampant without being quiet, and there is a drawback that intravenous administration to livestock such as cows, horses, and goats is a difficult task.

The advantage of (2) is that treatment for the purpose of oral administration of tablets, powders, and syrups is used as a therapeutic means for the treatment of sleeping sickness caused by human infection with Trypanosoma protozoa. The development of the drug has the advantage of making it easier to treat sleep sickness.

The advantage of (3) is that the majority of infants under the age of 5 are the age group in which the disease name is the cause of malaria, and the malaria parasite infects humans and dies. As a means of treating malaria infecting infants under 5 years of age, the advantage of malaria treatment using tablets, powders and syrup drugs is overwhelmingly easier than intravenous administration by injection. is there.

The advantage of (4) is that the infectious influenza virus, HIV described above
, HAV, HBV, HCB, HPV, HTLV-1, or other viruses, or bacteria such as O57, Mycobacterium tuberculosis, and vaginal chlamydia, or protozoa such as trypanosoma, malaria, syphilis, etc. ) And other treatments aimed at the oral administration of tablets, powders, and syrups formed using a complex of catechin and chloroquine or a complex of catechin and artesunate The development of a therapeutic drug has the advantage that the name of the disease makes it easier to treat infectious diseases such as influenza

As an advantage of (5), it is formed using the complex of catechin and chloroquine mixed with catechin and chloroquine, or the complex of catechin and artesunate mixed with catechin and artesunate, as described above. Tablets, powders, and syrups intended for oral administration are not decomposed in the small intestine of the digestive tract, so that the disease name is particularly effective for influenza, AIDS, malaria, resistant syphilis, and sleeping sickness Turned out.

In addition, as described above, catechin is easily decomposed in the digestive tract as a means of medication for administering catechin to the human body as a treatment for infectious diseases such as influenza and AIDS. As a means for administering to the human body without going through the intestinal tract, which is the digestive organ, the human body can be administered using the following means (1), (2), (3), and (4). Good.

  As (1), catechin is applied in liquid form to the nasal mucosa.

(2) is a peptide having a property of slipping through cells, for example, a peptide in which a plurality of amino acids are connected (hereinafter abbreviated as protein fragments) and catechin are mixed to form a liquid to form a nasal mucosa By spraying on the catechin, the catechin dissolves in the blood of the human body and easily reaches the blood.

As (3), epigallocatechin gallate (hereinafter abbreviated as EGCg or catechin) which is catechin, or EGCg (hereinafter referred to as EGCg) obtained by introducing a fatty acid into EGCg using enzyme lipase. EGCg dissolved in an aqueous solution mixed with 0.2% dimethyloxide (hereinafter abbreviated as GMSO) for the purpose of making an aqueous solution. The catechin EGCg or catechin is dissolved in the blood of the human body by applying the above liquid to the mucous membrane of the nose, or spraying the nose, or spraying the inside of the mouth. Easier to reach.

(4) As described above, after introducing fatty acid into EGCg using enzyme lipase and making EGCg as a new compound into an aqueous solution using GMSO, multiple amino acids were connected. It is a catechin by mixing the peptide with liquid and spraying it on the mucous membrane of the nose
EGCg dissolves in the blood of the human body and easily reaches the blood.

Furthermore, catechin (hereinafter abbreviated as EGCg or catechin) has a property of slipping through the inside of a cell, and a peptide in which a plurality of amino acids are connected is mixed with catechin to form a liquid and applied to the nasal mucosa. Or a nasal spray (hereinafter referred to as a nasal spray)
(Abbreviated as nasal drops for short), and using a peptide having a property of passing through the inside of the cell with the absorption rate of catechin, the absorption rate of catechin was increased. Also,
It is characterized by a therapeutic means for treating infectious diseases such as influenza viruses, rotaviruses that cause acute gastroenteritis, noroviruses, and malaria parasites.

In addition, the catechin extracted from tea leaves explained above has been found to have the effect of inactivating influenza viruses that are pathogens of influenza, other viruses, or malaria parasites. did. It has also been found to have anticancer effects. However, even if catechin extracted from tea leaves is administered orally, catechin is highly reactive with proteins, sugar chains, and lipids. There is a drawback that it is adsorbed by chains, lipids and the like and excreted outside the body, or catechin is decomposed in the intestine and excreted outside the body. As means for avoiding the disadvantages of this catechin, the means described in the following (1) to (31) can be used to make catechin difficult to be adsorbed to proteins, sugar chains, lipids, etc. There is a need to avoid being broken down in the stomach and intestinal tract, which are digestive organs.

As (1), catechin is directly adsorbed intravenously without going through the stomach and intestinal tract, which are digestive organs, to avoid catechin being adsorbed and decomposed in the intestinal tract. .

As (2), an enzyme lipase is allowed to act on catechin to introduce a fatty acid into catechin,
By synthesizing a new catechin compound (hereinafter abbreviated as a catechin derivative),
Even if a new catechin compound is administered orally, it is prevented from adsorbing and decomposing in the stomach and intestinal tract as digestive organs.

As for (3), tea leaf fine powder containing various catechins is not decomposed in the stomach and intestinal tract of the digestive organs of the human body, and the tea leaves are contained in the blood of the human body. The fine powder of tea leaves in the fine powder state is ingested in the intestine and the fine powder of tea leaves taken into the human blood is taken into the human blood, which circulates in the human blood The purpose is to dissolve various catechins in the blood of the human body and release the catechins into the blood by directly degrading tea leaf fine powder in the liver and kidneys that are organs And

As (4), what has been described above is as follows.
Without breaking down the fine powder of tea leaves in the stomach and intestinal tract, which are the digestive organs of the human body, the fine powder of tea leaves is taken into the blood of the human body through the intestinal tract into the blood of the human body. The purpose is to directly break down the fine powder of tea leaves in the liver and kidney through which the blood of the human body circulates.

As (5), examples will be described in the following (6) to (31).
First, the decomposition of fine powder of tea leaves is prevented from occurring in the stomach of a strong acid, which is a digestive organ. Secondly, tea leaf fine powder containing catechin in the blood of the human body by preventing decomposition of the tea leaf fine powder in the stomach and intestinal tract which are digestive organs. In the intestinal tract directly into the blood, and the tea leaf fine powder that has entered the blood is broken down directly in the liver and kidney where the blood circulates. The purpose is to dissolve the catechin contained in the leaves directly into the blood. Examples will be described below.

As (6), tea leaves, stems and stems (hereinafter abbreviated as tea leaves or tea) containing catechin are directly digested by the human body in the intestinal tract. The diameter of the tea leaves is 50μm or less, which is the diameter of the diameter that can be taken into the blood after ingestion,
Or 40 μm or less, or 30 μm or less, or 20 μm or less, or 10 μm or less, or 5.0 μm or less of the diameter of the tea leaves, using a tableting machine to make tablets into tablets Or a soft capsule or a hard capsule (hereinafter abbreviated as a capsule), and the human body orally administers it, so that the tablet containing fine powder of tea leaves inside the intestinal tract of the human body Or, the capsule will dissolve, and inside the intestinal tract, the human body can directly take in the fine powder of tea leaves into the blood of the human body, so it dissolves in the blood. Influenza virus, HIV, or malaria parasite (hereinafter abbreviated as infectious disease) can be inactivated or killed in the blood.

(7) As described above, inside a tablet, soft capsule, or hard capsule (hereinafter abbreviated as a capsule) obtained by tableting a fine powder of tea leaves using a tableting machine as described above, To prevent the capsule filled with fine powder of tea leaves from dissolving inside the stomach, which is the digestive organ of the human body, the tablet or the surface of the capsule is coated with a substance resistant to stomach acid The enteric tablet that does not dissolve in the stomach but dissolves in the intestinal tract, or the tablet or capsule filled with fine powder of tea leaves inside the enteric capsule By oral administration into the body, more efficiently in the intestinal tract, in the blood of the human body, the particle diameter of the fine powder of tea leaves is 50 μm or less, or 40 μm or less, or 30 μm or less, or 20 μm
Below, or 10 μm or less, or 5.0 μm or less of tea leaf fine powder is taken directly into the blood from the intestinal tract, so that influenza virus dissolved in blood, or HIV
Or infectious diseases such as Plasmodium can be inactivated or killed in the blood.

(8) As described above, orally administer the tablet obtained by tableting the fine powder of tea leaves using a tableting machine or the capsule filled with the fine powder of tea leaves as described above Because it is effective for patients with hay fever, as a trigger for the occurrence of hay fever symptoms, some viruses that are dissolved in the blood are involved in the occurrence of hay fever It may be provisional.

(9) As a fine powder of tea leaves, when tableting using a tableting machine, as a binder that is a binder, fine silicon dioxide, crystalline cellulose, lactose, maltose, and sucrose ester It is necessary to mix a caking agent such as the inside of the fine powder of tea leaves and mix them into tablets.

(10) As a soft capsule or a hard capsule (hereinafter abbreviated as a capsule), the fine powder of tea leaves is smoothened by improving the fluidity, and the fine powder of tea leaves is placed inside the capsule. When filling, inside the fine powder of tea leaves, additives such as lactose and rapeseed oil are mixed inside the fine powder of tea leaves for the purpose of improving fluidity. There is a need to smoothly fill the tea leaves with fine powder.

(11) As described above, using the processing means described above, the particle diameter of the tea leaves fine powder is 50 μm or less, or 40 μm or less, or 30 μm or less, or 20 μm or less, or 10 μm or less. Or a tablet of a fine powder of tea leaves having a size of 5.0 μm or less, which is tableted using a tableting machine to coat the surface of the tablet and dissolve in the intestinal tract, or Soft capsule,
Or, on the surface of the capsule filled with a fine powder of tea leaves inside a hard capsule (hereinafter abbreviated as a capsule), like the above tablet, the capsule does not dissolve inside the stomach. Tea leaves are administered orally by the human body by administering orally administering capsules filled with fine powder of tea leaves into enteric capsules that are intended to be coated on the surface of the capsules and dissolved in the intestinal tract. The fine powder of is not decomposed in the stomach and intestinal tract of digestive organs, but the fine powder of tea leaves is taken into the blood of the human body and ingested in the blood in the intestine,
As a result, fine powder of tea leaves directly in the liver and kidney where human blood circulates, for example, fine powder of tea leaves with a particle diameter of 50 μm or less in the liver and kidney. Anti-viral effect against influenza virus, AIDS virus, hepatitis virus, norovirus, rotavirus, HPV, etc. dissolved in blood, trypanosoma protozoa, syphilis, Antiprotozoal effect such as malaria parasite, or anticancer effect (
Hereinafter, it is referred to as infectious disease for short.

(12) As described above, the tea leaf fine powder in the intestinal tract is not decomposed in the digestive organs stomach and intestinal tract, which is the means described above. The fine powder of tea leaves is broken down in the liver and kidney where blood is circulated by ingesting into the blood, and various catechins contained in the fine powder of tea leaves are contained in the blood. As a result, the catechin, which is the main purpose of the present invention, is intravenously administered and dissolved in the blood, resulting in influenza virus, AIDS virus, hepatitis virus, Antiviral effect against norovirus, rotavirus, HPV, etc., or antiprotozoal effect such as trypanosomiasis, syphilis, malaria parasite, etc., or anticancer effect (hereinafter abbreviated as infectious disease). , The same effect as the effect of administering catechin intravenously will occur.

As (13), as described above, the development of a drug for the purpose of oral administration to increase the sensitivity of quinine, chloroquine, and artesunate, which are the specific drugs of the malaria parasite that is the main focus of the present invention, Catechin and quinine extracted from tea leaves with hot water, or catechin mixed with chloroquine to develop drugs for oral administration, or catechins extracted from tea leaves with hot water mixed with artesunate. However, as explained above, catechin is easily degraded in the stomach and intestinal tract as digestive organs and excreted outside the human body. As a raw material for hot water extraction of catechins, a mixture of fine tea leaf powder and chloroquine is used to form a tablet, or the same tea Filled capsules by mixing fine powder of leaf and artesunate to form a tablet, or mixed fine powder of tea leaf and chloroquine, or also fine powder of tea leaf and artesunate It is better to form a capsule with catechin and quinine, or catechin and chloroquine, or catechin and artesunate. It has been found that the development of a drug by mixing and combining artesunate with a drug has a higher sensitivity to antimalarial activity and can develop a drug with higher sensitivity to resistant malaria parasites.

(14) Oral administration of a tablet or capsule in which tea leaf fine powder and chloroquine or tea leaf fine powder and artesunate are mixed as an antimalarial treatment means described above However, it can be made of tea leaves and chloroquine, or tea leaves and artesunate. Even if the tablets or capsules and quinine, chloroquine or artesunate are orally administered separately, the same effect is obtained.
However, the powder of tea leaves is mixed with a larger amount of caking additive to form a hardened tablet, which cannot be easily broken down in the stomach, which is the digestive organ. Then it is necessary to make the tablet dissolve. The size and thickness of the tablet are also conditions that make it difficult to dissolve in the stomach of the digestive organs. Furthermore, by using sugar-coated tablets that are made as thick as possible using sugar on the surface of the tablets, tablets that firmly harden the fine powder of tea leaves do not dissolve inside the stomach. The sugar coating made of sugar coated and coated on the surface of the tablet will dissolve inside the stomach, and the tablet that firmly hardens the fine powder of tea leaves will It can be made into a tablet for the purpose of enteric dissolution that does not dissolve inside.
In the equatorial zone, about 1 million infants around the age of 5 die annually due to acute gastroenteritis that develops mainly due to rotavirus and norovirus.
In addition, in the equatorial zone and sub-Saharan Africa, malaria is infected and about 2 million infants around the age of 5 die. As a therapeutic means to eradicate rotavirus, norovirus, and malaria parasite, which are the cause of the death of this infant, tablets made of tea leaves using a tableting machine, and tea Develop capsules filled with fine powder of leaves. Especially for infants, the surface of tablets made from fine powder of tea leaves is used as sugar-coated tablets using sugar, or chocolate or coffee-flavored sugar-coated tablets are used for infants to make tea easier to drink. By orally administering a tablet in which the fine powder of the leaves is hardened, the fine powder of the tea leaves is ingested in the intestinal tract and directly decomposed in the liver and kidney of the infant, and the blood of the infant When catechin is dissolved and released, it becomes a therapeutic means for the purpose of eradicating acute gastroenteritis or malaria.

As for (15), the diameter of the particle diameter that can be absorbed and ingested by the intestinal tract, which is the digestive organ of the human body, is a substance having a particle diameter of 50 μm or less. As explained above,
The fine powder of tea leaves uses a millstone to produce matcha tea such as gyokuro from tea leaves,
Hosokawa Micron Co., Ltd., which produces fine tea leaves or has its headquarters in Hirakata City, Osaka Prefecture
, Which is manufactured and sold by the company, or manufactured by the Furukawa Industrial Equipment Systems Co., Ltd., headquartered in Tokyo Use a dream mill to produce fine powder of tea leaves, or powder tea that is served as tea at a sushi restaurant, heat steamed raw tea leaves picked from tea leaves During the manufacturing process, about 10% fine tea powder is produced.
In the region of Yame City, where tea is produced, the size of the sieve mesh that has passed through the sieve mesh of No. 25 is powdered tea. The size of the size of the powdered tea that passed through the mesh of the No. 25 sieve is 5 mm or less, or 4 mm or less, or 3 mm or less, or 2 mm or less for large ones, 50 μm or less, or 40 μm or less for small ones, Or, it is served at a sushi bar where powdered tea powders of various sized particle sizes are mixed, up to 30 μm or less, or 20 μm or less, or 10 μm or less, or 5.0 μm or less. Tea powder.

As for (16), the size of the powdered tea served at the sushi restaurant explained above is 50 μm.
Powdered tea with a size of 50 μm or less is mixed with powdered tea served at sushi restaurants. Use the fine powder of tea leaves from this sushi restaurant, or use the millstone as described above, or the brand name is a jet mill, or the brand name is a dream mill. When a fine powder is produced, a fine powder of tea leaves having a particle diameter of 50 μm or less, or 40 μm or less, or 30 μm or less, or 20 μm or less, or 10 μm or less is obtained for each of a stone mill, a jet mill, or a dream mill. . Fine particles of silicon dioxide as a binder that is a binder in the inside of the fine powder of tea leaves produced using this stone mill, or jet mill, or dream mill, or the inside of powdered tea that is put out at a sushi restaurant, Binders such as crystalline cellulose, lactose, maltose, and sucrose ester are mixed inside the fine powder of tea leaves and compressed into tablets using a tableting machine, or inside the capsules For the purpose of filling the tea leaf fine powder and the tea leaf fine powder into the capsule smoothly with milk powder or rapeseed oil, etc. It is necessary to mix inside the fine powder of tea leaves and smoothly fill the inside of the capsule with fine powder of tea leaves.

(17) As described above, a tablet obtained by tableting a tea leaf fine powder using a tableting machine, or a capsule filled with tea leaf fine powder, as described above, is orally administered to the human body. In some cases, the digestive organs are broken down in the stomach and intestinal tract, but in the intestinal tract, fine powder of tea leaves of 50 μm or less is directly taken into the blood. If the purpose is to ingest more tea leaves fine powder in the intestinal tract, tablets with tea leaves fine powder,
Alternatively, the capsule surface is coated with a substance resistant to gastric acid and enteric tablets intended to dissolve inside the intestine, or enteric purposes intended to dissolve inside the intestine. It is recommended to use capsules.
However, depending on the conditions, it may not be necessary to use enteric tablets or enteric capsules. For example, when tableting a tea leaf fine powder, the type of binder mixed as a binder as a binder inside the tea leaf fine powder, and the binder to be mixed Depending on the amount of binder used, tablets and capsules that are intended to be dissolved in the intestinal tract without being completely dissolved in the stomach, which is the digestive tract, are formed. I can do it.

(18) In order to kill resistant malaria parasites by mixing and using tea leaf fine powder and quinine, or tea leaf fine powder and chloroquine, or tea leaf fine powder and artesunate. The catechin contained in tea leaves can be combined with iron (Fe) that constitutes erythrocytes, so that quinine, chloroquine, and artesunate alone can be administered orally. It is better to mix and use tea leaf fine powder and quinine, tea leaf fine powder and chloroquine, or tea leaf fine powder and artesunate together, than to administer. This is the reason for the increased sensitivity.

As (19), the leaves of oak leaves, particularly astringent leaves (hereinafter abbreviated as oak leaves), contain more catechins than the catechins that tea leaves contain. It is the leaves of oak trees. This oak leaf fine powder is used in place of the tea leaf fine powder described above, and oak leaf fine powder and quinine, or chloroquine, or oak leaf fine powder and artesunate In combination with quinine, chloroquine, or artesunate alone, a more sensitive drug for oral administration was developed to kill resistant Plasmodium. May be.

(20) As rooibos tea, mangrove, pine nut shell, or green tea,
Or tea, or wheat, or barley tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea, or coffee, or a dry, oak tree chip or cherry tree chip Or apple tree chips, beech tree chips, oak tree chips, walnut tree chips, hickory tree chips, maple tree chips, oak trees, cherry trees Mixed wood chips such as trees, beech trees, oak trees, maple trees, or birch wood chips, or other wood chips, green tea, black tea, chlorella, chlorella tea, Tochu tea, barley tea, brown rice Tea, coffee, cocoa, octagonal fine powder, pine nut powder, mangrove trunk and branch and leaf powder, Rosaceae strawberry tea (Tencha), Rosaceae strawberry tea, yellow tea (Pei Chi tea) , Cat's claw (cat owl tea), Kuzuka tea, Tahibo tea native to the Amazon, Rooibos tea native to Africa, Eye drops wood tea (Megsurinoki tea), Indian native gymne tea, Rafu hemp Tea, cod leaf tea, Iperosho tea, Umeyama Shusui tea, Propolis tea, Ganoderma tea, Chitosan tea, Sashigoka tea (Yusu tea), Fu ■ tea (Puer tea)
, Turmeric tea, carrot tea, dokudami tea, tomorrow leaf tea (Ashitaba tea), candy tea tea (Amacha tea), aloe tea, ginkgo leaf tea, oolong tea, psyllium tea, oyster leaf tea, garcinia tea, gymnema tea, guava Tea, rich tea, Kumazasa tea, mulberry leaf tea, sijuum tea, perilla leaf tea, jasmine tea, sugina tea, buckwheat tea, tabebuiya tea, cod leaf tea, ten tea, dokudami tea, herbal tea, ning tea Tea), pearl barley tea, banaba tea, hub tea, loquat leaf tea, ratio tea (pai tea tea), mate tea, umeyama shusui tea, eucalyptus tea, mugwort tea, rakanka tea, rakuma tea, longi tea (longines tea) ), Etc., or ginseng, licorice, ground yellow, juju,
Or Kakkon, Toki, Shakuyaku, Ginger, Koboku, Rokujo, or Chinese herbal medicine, Bushi, Hanka ), Daio, Kyonin (hereinafter abbreviated as grass root bark, or herbal medicine,
Or the like, for example, using the processing means described above, the diameter of the particle diameter is 50 μm or less, or 40 μm or less, or 30 μm or less, or 20
Enteric-coated tablets that are coated on the surface of tablets by tableting a fine powder of rooibos tea that is less than 10 μm, 10 μm or less, or 5.0 μm or less using a tableting machine, and dissolved in the intestine Or a soft capsule or a hard capsule (hereinafter abbreviated as a capsule) filled with a fine powder of Rooibos tea, and the capsule is placed inside the stomach in the same manner as the above tablet. To prevent dissolution, the human body orally administers a capsule filled with fine powder of rooibos tea inside the enteric capsule intended to be dissolved on the intestinal tract by coating the surface of the capsule The rooibos tea fine powder is not broken down in the digestive organs stomach and intestinal tract, and the rooibos tea fine powder is taken into the human blood by the intestinal tract. By fine powder Suti is the ingestion incorporated, liver human blood is circulating as a result, and a fine powder directly rooibos in kidney. For example, the fine powder of rooibos tea with a particle diameter of 50 μm or less is the liver,
And it will be decomposed directly in the kidney, so it has antiviral effect against influenza virus, AIDS virus, hepatitis virus, norovirus, rotavirus etc. dissolved in blood, trypanosoma protozoa, syphilis And anti-protozoan effects such as malaria parasites, or anti-cancer effects (hereinafter abbreviated as infectious diseases).
However, as explained above, depending on the conditions, a tablet in which a fine powder of rooibos is compressed, or an enteric tablet or enteric capsule coated on the surface of the capsule. There may be no need to.

(21) is a fine powder of tea leaves having a particle diameter of about 50 μm or less (hereinafter abbreviated to 50 μm or less), and ingested into the blood in the intestinal tract of the digestive tract. Infants, infants around 5 years old are infected with fine powder of tea leaves with a particle diameter of 50 μm or less that can be incorporated into the flu, acute gastroenteritis, and malaria (hereinafter abbreviated as infectious diseases) As a therapeutic means for treating infectious diseases such as, tea leaf fine powder and syrup having a particle diameter of 50 μm or less, such as chicken pox or honey (hereinafter abbreviated as syrup) )
Fine powder of tea leaves mixed with tea powder, etc. are orally administered to infants around 5 years old, and then in the intestinal tract, the digestive organ of the human body, fine powder of tea leaves To absorb the fine powder of tea leaves of 50 μm or less into the blood of the human body, absorb into the blood, and mix the fine powder of tea leaves of 50 μm or less mixed in the blood with the liver, And 50 μm
Catechin is produced in the liver in the process of degrading the following tea leaf fine powder in the liver, and the antibacterial action of catechin is used to treat infectious diseases such as influenza, acute gastroenteritis, and malaria. It is a therapeutic means for treating infectious diseases by using effects such as antiviral action and antiprotozoal action.

(22) As described above, the diameter of the fine particle of tea leaves, as described above, is 50 μm.
A liquid syrup in which quinine, chloroquine, or artesunate (hereinafter abbreviated as chloroquine) is mixed into a liquid inside of a mixture of fine powder of tea leaves and syrup mixed with m or less, and the disease name is malaria A therapeutic means for treating malaria and other infectious diseases by oral administration to infants around 5 years old, as a therapeutic agent for therapeutic means such as influenza and sleeping sickness (hereinafter abbreviated as infectious disease) To do.

As for (23), the diameter of the particle size, which is a fine powder of tea leaves, is 50 μm or less, and the diameter of the particle diameter that can be taken into the blood by ingestion into the blood in the intestinal tract of the digestive tract is 50 μm or less. As a therapeutic means of treating infectious diseases such as influenza, acute gastroenteritis, AIDS, hepatitis, and malaria (hereinafter abbreviated as infectious diseases), The fine powder of tea leaves with a powder particle diameter of 50 μm or less is allowed to smoothly reach the stomach and intestinal tract as digestive organs, and the fine powder of tea leaves is taken into the blood of the body. For the purpose of dissolution, the tea leaf fine powder is compressed into tablets using a tableting machine, or the capsule filled with tea leaf fine powder is taken orally. Administer as a means of treating infectious diseases.

As for (24), the diameter of a tea leaf fine powder having a particle diameter of 50 μm or less, and the diameter of the particle diameter that can be taken into the blood by ingestion into the blood in the intestinal tract of the digestive tract is 50 μm or less. As a therapeutic means of treating infectious diseases such as influenza, acute gastroenteritis, AIDS, hepatitis, and malaria (hereinafter abbreviated as infectious diseases), Nucleated tablets with a double or triple tablet structure for the purpose of dissolving fine powder of tea leaves with a particle diameter of 50 μm or less inside the intestinal tract, the digestive organ. The structure is as follows. For example, the center part of a tablet is a tablet in which fine powder of tea leaves is tableted, and the outer periphery of this tablet is made into a sugar-coated tablet using sugar to make a sugar-coated tablet. On the outer peripheral surface of the tablet that was tableted using a tableting machine, the sugar-coated tablets that were sugar-coated using sugar again were not decomposed inside the stomach, which is the digestive organ. In the inside of the intestinal tract, the use of a tablet having a tablet structure with a double structure or a triple structure having a tablet structure for the purpose of dissolving and dissolving the tablet, influenza, And therapeutic means for treating infectious diseases such as malaria.

(25) As a fine particle of tea leaves, when the diameter of the particle diameter is 50 μm or less,
The diameter of the fine powder of tea leaves is, for example, the diameter of a very small fine powder of 20 μm or less. The smaller the fine powder of tea leaves, the smaller the fine powder of tea leaves. In the blood, the tea powder powder is ingested in a larger amount and easily enters the blood of the human body.
There is just a problem here. For example, when the diameter of the tea leaf fine powder is set to 20 μm or less, the disadvantage is that the tea leaf fine powder is extremely small in hot water or water. Due to the surface tension of the fine powder of leaves, the fine powder of tea leaves in hot water or water has the disadvantage that it does not settle without being dissolved and dissolved with hot water or water. As a means for solving this drawback, tablets of tea leaves are compressed into tablets using a tableting machine, or orally administered by filling tea leaves with a fine powder of tea leaves. By doing this, the fine powder of tea leaves having a diameter of, for example, 20 μm or less can reach the inside of the intestinal tract as a digestive organ.

As for (26), when filling the inside of a hard capsule with tea powder, the magnesium stearate lubricant is mixed with the inside of the tea leaf powder as an excipient. Then, the fine powder of tea leaves can be filled into the hard capsule smoothly. In the case of hard capsules, the inside of the hard capsules is filled with fine powder of tea leaves, and then the hard capsule surface is coated on the surface of the hard capsules using a resin that is resistant to stomach acid inside the stomach. A hard capsule intended to dissolve the alkaline solution in the intestinal tract can be formed.

(27) Synthetic resin synthesized from a polysaccharide substance of corn powder on the surface of the tablet after the fine powder of tea leaves was compressed into tablets using a tableting machine By coating the surface of the tablet with a zein resin named Twein, an enteric solution intended to be dissolved in the intestinal tract of an alkaline solution without dissolving in the stomach acid inside the stomach. Tablets can be formed.

As for (28), when the manufacturing process of the hard capsule and the soft capsule described above is compared, in the case of the hard capsule, an active lubricant such as magnesium stearate is used as a shaping agent. However, in the case of soft capsules, it is a manufacturing method that uses vegetable oil such as rapeseed oil to wrap fine powdered tea leaves, so catechins containing fine powdered tea leaves, There is a drawback that the rapeseed oil which is the raw material of the soft capsule is chemically bonded. However, since there is an advantage that the excipients magnesium stearate and catechin, which are used in the case of hard capsules, do not chemically bond, hard capsules were used as capsules when filling fine powder of tea leaves. However, there is an advantage that the loss of catechin is small and the amount of catechin dissolved is further increased.

As (29), the exact same as described above is mixed when mixing tablets and mixed. When used as a binder as a binder, fine powder of tea leaves The inside of the fine powder of tea leaves is a binder that is a binder, excluding substances that contain proteins, sugar chains, and lipids that are chemically bonded to the catechins contained in Need to be mixed and compressed to form tablets. As a binder that is a binder, for example, fine particles of silicon dioxide, crystalline cellulose, and sucrose ester, which are substances that do not chemically bond to catechin, are mixed inside a fine powder of tea leaves and compressed into tablets. If the tablet is made into a tablet, there is an advantage that the loss of catechin is small and the amount of catechin dissolved is further increased.

(30) As described above, the diameter of the fine particle of tea leaves is 50 μm or less, or 40 μm or less, or 30 μm or less, or 20 μm or less, or 10 μm or less, or 5.0 μm or less,
By intravenous administration or intraperitoneal administration of fine powder of tea leaves that can pass through a PTFE filter of 1.0 μm or less, or 0.45 μm or less, or a PVDF filter of 0.45 μm or less, In the process of degrading tea leaf fine powder in the human liver and kidney, and then degrading tea leaf fine powder in the human liver and kidney, the tea leaf fine powder contains Antibacterial, antiviral, and antiprotozoal effects of catechins (hereinafter abbreviated as antibacterial effects)
Catechins are produced in the human liver and kidney, and catechins are dissolved in the blood of the human body and eluted, so that influenza viruses, AIDS viruses, and malaria are dissolved in the blood. To inactivate the cause of infectious diseases such as protozoa, a therapeutic means aimed at treating infectious diseases using the antibacterial effect of catechin.

As for (31), if the diameter of the tea leaf fine powder is 50 μm or less, the diameter of the tea leaf fine powder becomes extremely small, so the tea leaf fine powder is contained. Since catechins oxidize by reaction of catechins in the air with oxygen in the air, when tableting tea leaf fine powder into tablets, the tea leaf fine powder contains In order not to oxidize the catechins that are used, tablets of tea leaves are tableted to form tablets, and the surface of the tablets is sugar-coated to block oxygen in the air or enteric-coated hybromellose Phthalates (hereinafter referred to as
It is necessary to coat the surface of the tablet with a resin such as Twein resin or shellac to prevent contact between the surface of the tablet and oxygen in the air.

Further, FIG. 10, FIG. 11, FIG. 12 and FIG. 13 show bancha, which is a tea leaf,
In order to process green tea, green tea, green tea and gyokuro (hereinafter abbreviated as tea leaves) into fine powder, the measurement diagram shown in FIG. 10 uses a stone mill. The measurement figure which used tea leaves as fine powder is shown. The measurement figure shown in FIG. 11 has shown the measurement figure which used the tea mill for the fine powder using the ball mill. The measurement diagram shown in Fig. 12 shows that the product name manufactured and sold by Hosokawa Micron Co., Ltd. in Hirakata City is a jet mill (airflow type grinding method), or the Furukawa Industrial Equipment System Co., Ltd. in Tokyo. Is a measurement diagram in which tea leaves are made into fine powder using a dream mill (vortex type airflow crushing method). The measurement diagram shown in FIG. 13 shows a measurement diagram in which the supernatant of powdered tea served at a sushi restaurant is filtered and only the supernatant of powdered tea served at a sushi restaurant is measured.

Further, according to the measurement diagram shown in the measurement diagram of the fine powder of tea leaves processed by the processing means shown in FIGS. 10, 11, 12, and 13 described above, the tea Fine powder of tea leaves with a particle diameter of 50 μm or less that can be ingested and absorbed in the blood by the intestinal tract, the digestive organ of the human body 10 and FIG. 11 are used for the measurement of the tea leaves, and the ball mill shown in FIG. The particle diameter of the fine powder of leaves is 50
It shows that it contains 90% to 100% of tea leaf fine powder of μm or less. In addition, only the supernatant was measured by filtering the powdered tea served at the jet mill and sushi restaurant shown in FIG.
The measurement figure of tea leaf fine powder shows that it contains 75% or more of tea leaf fine powder having a particle diameter of 50 μm or less.

Furthermore, as an active ingredient contained in the fine powder of tea leaves, as an active ingredient other than catechin, which is a polyphenol, a polysaccharide and a complex polysaccharide (hereinafter abbreviated as a complex polysaccharide or catechin). ). It has been proved that this complex polysaccharide has an extremely high blood glucose lowering effect and has an effect of maintaining normal blood sugar level in the human body. Therefore, it is reported in Patent Publication No. 2519443 that it is effective as a hypoglycemic agent and an anti-diabetes drug and can be used as a functional food and a health food. However, the implementation means is more complicated than the embodiment of the present invention. In the present invention, a fine powder of tea leaves is formed into tablets, granules, capsules, syrups, and powders (hereinafter abbreviated as tablets or catechin tablets) or enteric coated on them. By administering the tablets orally, the fine powder of tea leaves with a particle diameter of 50 μm or less in the intestinal tract, which is the digestive organ, is taken into the blood of the human body to ingest blood. Let me take in the liver of the human body,
And the blood sugar level in the blood is lowered by decomposing fine powder of tea leaves in the kidney and producing complex polysaccharides contained in the fine powder of tea leaves in the liver and kidney. Hypoglycemic agents for the purpose of, for example, insulin whose dosage form is an injection solution, or hypoglycemic agents similar to hypoglycemic agents such as buformin hydrochloride, tributamide, exenatide in formulations intended for oral administration I can do it. However, the difference from the case where the complex polysaccharide contained in the tea leaf fine powder is used for the purpose of lowering the blood sugar level in the blood is that the tea leaf fine powder containing the complex polysaccharide is used. In addition, hypoglycemic agents such as insulin, buformin hydrochloride, tributamide, and exenatide, which are the above hypoglycemic agents, may cause lactic acidosis,
Each has many side effects.

Further, catechins, polysaccharides, and complex polysaccharides (hereinafter, abbreviated as catechins or complex polysaccharides) contained in tea leaf fine powder lower the blood glucose level described above. In addition to the effects, there is an effect of lowering blood pressure and maintaining normality. The reason for this is that catechins contained in fine powder of tea leaves, or complex polysaccharides, particularly catechins are fats, sugar chains,
In addition, it is a substance having a strong property of causing a condensation reaction with protein and binding. For example, fats, sugar chains, proteins, and other waste products that have accumulated inside the blood vessels of the human body and deposited on the inner walls of the blood vessels can be removed from the catechins and complex polysaccharides to be excreted outside the human body. There is a working effect.
Contains fat, sugar chains, proteins, and other waste products (hereinafter abbreviated as waste products) that accumulate in the blood vessels of the human body and deposit on the inner walls of the blood vessels. Since the catechin and the complex polysaccharide are combined with a condensation reaction and the waste is excreted outside the human body, the blood pressure of the human body is lowered and normal blood pressure is produced. In addition, a tablet, granule, capsule and powder, or an enteric solvent in which an enteric coating is applied to a fine powder of tea leaves, has an action effect as an antihypertensive agent.

Furthermore, the catechin described above has the effect of reducing the blood pressure of the human body,
As a feature of catechin, catechin has a strong action of causing a condensation reaction with sugar, sugar, and sugar chain (hereinafter, abbreviated as sugar) and binding. Diabetes is a disease that develops when the blood sugar level in the blood becomes high because the sugar in the blood cannot be decomposed and excreted. The sugar in the blood that causes the blood sugar level in the blood to rise and causes diabetes is taken into the blood, and the fine powder of tea leaves is taken in from the intestinal tract, the digestive organ, and absorbed into the blood. The tea leaves are broken down by the liver and kidneys, and the catechins contained in the tea leaves are produced in the blood. The sugars and catechins present in the blood And catechins that are bound to sugar in the blood are excreted outside the human body, so that the blood sugar level in the blood can be lowered, so catechins are produced in the blood and dissolved. Since catechin has the action of lowering blood pressure and lowering blood pressure as described above, and catechin has both the action and effect of lowering blood glucose level, it can be used as a means of treating diabetes. And important for diabetes There is an effect that the care means.

In addition, as described above, the disease name is malaria. Malaria is a disease caused by malaria parasites mediated by anopheles mosquitoes that live in the tropics centered on the equator. Malaria is unique to the tropics. It is a disease mediated by anopheles mosquitoes, and more than 2 million people die each year. Death from AIDS virus is an artificial illness and can be prevented without sexual activity. Malaria kills the most lives on the planet, and malaria is the first death rank. Secondly, death rank is the second most killing.
Rotavirus, sapovirus, norovirus, adenovirus, and astrovirus (hereinafter abbreviated as rotavirus) that cause vomiting and diarrhea in infants and children About 1 million infants and children are said to die from acute gastroenteritis that develops due to rotavirus that grows in the mucosa of the intestinal wall of the intestinal tract per year. The following (1), (2), and (3) describe acute gastroenteritis caused by malaria with the first rank of death and rotavirus with the second rank of death on the earth. The purpose is to treat with the treatment means.

(1) First, as a means for treating malaria, the specific drug for resistant malaria is for the purpose of enhancing the sensitivity of resistant malaria parasite to chloroquine and artesunate. When taking chloroquine and artesunate, the fine powder of tea leaves described above is in the form of tablets, granules, capsules, syrups, and powders (hereinafter abbreviated as tablets, Or catechin tablets), or tablets with enteric coating on them in combination with tablets made of chloroquine and artesunate, orally administered, the fine powder of tea leaves is decomposed in the blood. Since catechins are produced in the blood, the sensitivity of chloroquine and artesunate, which are specific drugs for resistant malaria parasites, is even greater. It becomes higher effect as to the occurrence.

(2) Secondly, as a treatment method for the disease name malaria, chloroquine and artesunate, which are specific drugs for resistant malaria parasites, and fine powder of tea leaves described above are mixed. Combined (combined) dosage forms are tablets, granules, capsules, syrups,
Chloroquine and artesunate by oral administration of powders (hereinafter abbreviated as tablets or catechin tablets) or enteric-coated tablets as a means of treatment for resistant Plasmodium. Therefore, the susceptibility to resistant malaria is even higher than when chloroquine and artesunate, which are specific drugs for resistant malaria, are used alone.

(3) Third, the death rank on earth is the death rank of malaria, which is the first in the name of the disease, and the second death rank is the most cruel on the earth. Tea leaves described above as a therapeutic means for the purpose of treating acute gastroenteritis that develops due to rotavirus that grows in the mucosa of the intestinal tract of the second largest intestinal Acute gastroenteritis of tablets, granules, capsules, syrups and powders (hereinafter abbreviated as tablets or catechin tablets), or tablets with enteric coating on these powders Orally administered as a means of treatment for the patient, the tablet of tea leaf fine powder is compressed, or the tea leaf fine powder is contained inside the intestinal tract where the intestinal solvent is the digestive organ. Water-soluble catechins diffuse inside the intestinal tract Because the water-soluble catechin diffuses inside the intestine, rotavirus growing in the intestinal mucosa is killed or inactivated by the antibacterial effect of catechin. Oral administration of a tablet obtained by tableting a fine powder or an enteric-coated tablet on the tablet provides a means for treating acute gastroenteritis.

In addition, enteric solvent with fine powder of tea leaves in the form of tablets, granules, capsules, syrups and powders (hereinafter abbreviated as tablets or catechin tablets) or enteric coatings on them When the diameter of the fine powder of tea leaves is the following (1), (2), (3
As shown in (4) and (4) above, the fine powder of tea leaves can be ingested in the intestinal tract of the digestive organs of the human body, and the diameter of the particle diameter is 50 μm or less. 30% or more, or 40% or more, or 50% or more, or 60% or more, or 70% or more, or 75% or more, or 80% or more, or 90% or more, or 99% or more It is necessary to contain the fine powder of tea leaves.

(1) The measurement chart of particle size distribution shown in FIG. 10 shows a measurement chart in which tea leaves are used as a fine powder using a stone mortar. According to the measurement diagram using tea mill leaves and tea leaves as a fine powder, the particle diameter is less than 50μm, which is the diameter of the particle diameter that can be ingested in the intestinal tract, the digestive organ of the human body. Since the measurement chart of particle size distribution shown in Fig. 10 shows that the tea powder contains 95% to 100% fine powder, the most suitable tablet for forming enteric solvent It is the diameter of the fine particle size of tea leaves.

(2) The measurement diagram of the particle size distribution shown in FIG. 11 shows a measurement diagram in which tea leaves are finely powdered using a ball mill. According to the measurement diagram using tea leaves as a fine powder using this ball mill, the diameter of the particle that can be ingested in the intestinal tract, the digestive organ of the human body, is 50.
It contains 90% to 100% tea leaf fine powder with a particle size of μm or less.
Since the measurement chart of the particle size distribution shown in FIG. 11 shows, as a tablet forming the enteric solvent,
It is the diameter of the particle size of the most optimal tea leaf fine powder.

(3) The measurement diagram of the particle size distribution shown in FIG. 12 shows a measurement diagram in which tea leaves are finely powdered using a jet mill (airflow pulverization method). According to the measurement diagram using tea mill leaves as a fine powder using this jet mill, the particle size of 50 μm or less, which is the diameter of the particle size that can be ingested in the intestinal tract, the digestive organ of the human body The particle size distribution measurement chart shown in FIG. 12 shows that the tea leaves contain 75% or more of fine powder of tea leaves.

(4) The measurement chart of the particle size distribution shown in FIG. 13 shows a measurement chart in which only the supernatant obtained by filtering powdered tea served at a sushi restaurant is measured. According to the measurement diagram measuring only the supernatant obtained by filtering the powdered tea served at this sushi restaurant, particles with a diameter of 50 μm or less that can be ingested in the intestinal tract, the digestive organ of the human body The measurement chart of the particle size distribution shown in FIG. 13 shows that 75% or more of fine powder of tea leaves having a large diameter is contained.

As shown in FIG. 10, FIG. 11, FIG. 12, and FIG. 13, when tablets are formed by tableting fine powder of tea leaves, they are ingested through the intestinal tract, the digestive organ, 30% or more, or 40% or more, or 50% or more of the mixture of fine powder of tea leaves with a particle diameter of 50 μm or less that can be absorbed into the body Or 60% or more, or 75% or more of the tea leaf fine powder particle diameter of 50μm or less It is good to form a tablet using the raw material containing the fine powder of the particle diameter diameter, The four types of powdered tea served at the stone mill, ball mill, jet mill, and sushi restaurant shown in the particle size distribution measurement diagrams shown in FIGS. 10, 11, 12, and 13 are intestinal solvents. Figure 10 shows that the raw material for forming tablets was found to be optimal.
FIG. 11, FIG. 12, and FIG. 13 show the measurement diagrams of the particle size distribution.

Further, Table 17 below shows a blending table of catechin tablets in the case where tablets (hereinafter abbreviated as tablets or catechin tablets) are formed by tableting tea leaves with fine powder. Yes.

Also, a PTFE filter with a tea leaf fine powder particle diameter of 0.45 μm or less, or 0.45 μm
The fine powder of tea leaves that can pass through a PVDF filter of μm or less is dissolved in physiological saline (hereinafter abbreviated as water for injection) and dissolved in water for injection. By administering the fine powder of leaves intravenously, or intravenously, or intraperitoneally,
And catechins containing fine powder of tea leaves in the process of degrading fine powder of tea leaves in the liver and kidney of the human body by decomposing fine powder of tea leaves in the kidney Catechins that have antibacterial, antiviral, and antiprotozoal effects (hereinafter abbreviated as antibacterial effects) are produced in the human liver and kidney, and catechins dissolve in the human blood. In order to inactivate the causes of infections such as influenza virus, AIDS virus, and malaria parasite that are dissolved in the blood, the antibacterial effect of catechin is used to treat the infection. A therapeutic means intended to be performed.

Furthermore, the fine powder of tea leaves that can pass through a PTFE filter having a particle diameter of 0.45 μm or less, or a PVDF filter of 0.45 μm or less, with physiological saline (For short, water for injection), and the tea leaf fine powder dissolved in water for injection is administered intravenously, intravenously, or intraperitoneally. The catechin, polysaccharide, and complex polysaccharide (hereinafter, abbreviated as catechin or complex polysaccharide) that the fine powder contains, in addition to the effect of reducing the blood sugar level described above, It has the effect of lowering blood pressure and maintaining normality. The reason for this is that catechins or complex polysaccharides, especially catechins, contained in tea powders are strong substances that cause a condensation reaction with fats, sugar chains, and proteins and bind to them. . For example, fats, sugar chains, proteins, and other waste products that have accumulated inside the blood vessels of the human body and deposited on the inner walls of the blood vessels can be removed from the catechins and complex polysaccharides to be excreted outside the human body. There is a working effect. Contains fat, sugar chains, proteins, and other waste products (hereinafter abbreviated as waste products) that accumulate in the blood vessels of the human body and deposit on the inner walls of the blood vessels. Since the catechin and the complex polysaccharide are combined with a condensation reaction and the waste is excreted outside the human body, the blood pressure of the human body is lowered and normal blood pressure is produced. The fine powder of tea leaves that can pass through a PTFE filter with a particle diameter of 0.45 μm or less, or a PVDF filter with a diameter of 0.45 μm or less, is dissolved in water for injection. Intravenous or intraperitoneal administration has the effect of lowering the blood pressure of the human body and lowering the blood pressure of the human body to normal blood pressure, so adults with high blood pressure, anticancer, hay fever, etc. A therapeutic means aimed at treating the disease .

In addition, the catechin described above has the effect of reducing the blood pressure of the human body,
As a feature of catechin, catechin has a strong effect of binding by causing a condensation reaction with sugar, sugar, and sugar chain (hereinafter abbreviated as sugar). Diabetes is a disease that develops when the blood sugar level in the blood becomes high because the sugar in the blood cannot be decomposed and excreted. The blood sugar level in this blood is increased and the sugar content in the blood that causes diabetes is explained above, PTFE filter of 0.45 μm or less, or PVDF of 0.45 μm or less
Water for injection in which fine powder of tea leaves is dissolved, which can be passed through a filter made of water, is administered intravenously, or by intravenous drip, or intraperitoneal administration, and fine powder of tea leaves is liver and kidney To produce catechins in the blood containing the fine powder of tea leaves,
By combining catechins with sugars present in blood and catechins bound to sugars in blood, the blood sugar level in the blood can be lowered by excreting it outside the human body. Producing catechin in the blood and dissolving it can be a means of treating diabetes, lowering blood pressure as described above to catechin and lowering blood pressure, and reducing blood glucose level to catechin As described above, the injection is made by dissolving fine powder of tea leaves that can pass through a PTFE filter of 0.45 μm or less, or a PVDF filter of 0.45 μm or less. It is a therapeutic means intended to treat hypertension and adult diseases such as diabetes, anticancer and hay fever by intravenously or intraperitoneally administering water.

Furthermore, since caffeine containing the fine powder of tea leaves dissolved in the water for injection described above may have a harmful effect on the human body, Remove caffeine contained in the fine powder of tea leaves to be dissolved in water, and administer intravenously, intravenously, or intraperitoneally with water for injection in which fine powder of tea leaves is dissolved. In some cases, there is a need for a therapeutic means for treating adult diseases such as diabetes, hypertension, anticancer, hay fever, and infectious diseases.

In addition, using the fine powder of tea leaves described above, the dosage form forms tablets, granules, capsules, powders, syrups (hereinafter abbreviated as tablets or catechin tablets). The caffeine contained in the tea leaf fine powder used to do so may have a harmful effect on the human body, so the tea leaf powder is refined and processed during the process of purification. Adults with diabetes, hypertension, anticancer, hay fever, etc. by oral administration of tablets or catechin tablets made from tea leaf fine powder, from which caffeine contained in the powder of green leaves has been removed There may be a need for therapeutic means for treating diseases, infections, and the like.

Furthermore, caffeine contained in green tea, which is a fine powder of tea leaves, is also contained in coffee, tea, oolong tea, cocoa, chocolate and the like other than green tea. Caffeine is a kind of alkaloid. It is a kind of purine alkaloid with a purine ring and is named because it is contained in coffee. In addition, the strongness of sodium benzoate caffeine
It is also used as a central nerve stimulant that is a medical stimulant. Furthermore, since it is said that it has the effect | action which inhibits the repair of DNA of the cancer cell which the anticancer agent destroyed, there exists an effect which raises action effects, such as an anticancer agent. Since caffeine contained in green tea, which is a fine powder of tea leaves, binds to tannin and its effect is suppressed, the awakening action of coffee is weak and acts slowly.

In addition, enteric acid for the purpose of surface treatment as hybromellose phthalate, zein, shellac, or other enteric solvents at the stage of tea leaves (hereinafter abbreviated as green tea). Using a coating material (hereinafter abbreviated as HPMCP), an enteric coating treatment is performed on the surface of green tea leaves to make enteric solvent using HPMCP, or green tea leaves Green tea leaves, which are made from enteric-coated green tea leaves with HPMCP infiltrated into the inside of the green tea leaves at the same time as the raw material, and the green tea leaves as enteric solvent properties On the surface of the tea leaves fine powder using HPMCP at the stage of tea leaf fine powder, using green leaves to form tea powder fine powder or green tea fine powder Enteric coating or Using tea leaf fine powder (hereinafter abbreviated as tea leaf fine powder) in which HPMCP is infiltrated into tea leaf fine powder at the same time on the surface of tea leaf fine powder Effects and Examples of Treatment Means for Treatment of Infectious Diseases such as Influenza, Rotavirus, Hepatitis, AIDS, Diabetes, Hypertension, Anticancer, Pollen Disease (hereinafter referred to as Adult Disease) Will be described in the following (1) to (38).

Further, the tea leaf fine powder in which HPMCP is infiltrated into the fine powder of tea leaves on the surface of the fine powder of tea leaves or at the same time as the fine powder of tea leaves explained above. Powder (hereinafter,
Infectious diseases such as influenza, rotavirus, hepatitis, AIDS, etc., or diabetes, hypertension, anticancer, hay fever (hereinafter referred to as adult disease)
Examples of the effects and examples of the treatment means for the treatment using candy, such as cereal, gummy candy, potato chips, rice crackers, bread etc.
This will be described in 1) to (38).

In addition, the fine powder of tea leaves described above, or the fine powder of tea leaves coated with enteric coating using HPMCP (hereinafter abbreviated tea leaf powder) The main actions of caffeine contained in green tea, which is a fine powder) are effective in arousal action, cerebral arteriole contraction action, diuretic action, sleepiness and fatigue. However, insomnia and dizziness may appear as side effects. Fine powder of tea leaves containing this caffeine, fine powder of coffee beans made from fine coffee beans, fine powder of instant coffee or tea leaves, or fine powder of leaves of oolong tea The main action of caffeine contained in the tea leaf for a short time is awakening action. The content of caffeine contained in the tea leaf fine powder contains about 5% of caffeine with respect to the content of the tea leaf fine powder. When the human body consumes a large amount of caffeine, which contains the fine powder of tea leaves,
For example, for the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an old man, or for the purpose of waking up the sleepiness of a driver driving a car, or for the purpose of waking up the sleepiness of a student studying for an examination, Or for the purpose of treating acute gastroenteritis that develops due to influenza, rotavirus, or norovirus, or a catechin containing fine powder of tea leaves, and the name of the disease is a special drug for malaria. The purpose of treating malaria with a combination of a certain chloroquine and catechin, or a combination of artesunate and catechin, or the purpose of treating diabetes by lowering blood glucose level, or reducing blood pressure to increase hypertension (Hereinafter, abbreviated as infectious disease), or effects and examples relating to the intended effect for treating adult diseases such as anticancer or hay fever, ), (2), (3), (4), (5), (6), (7),
(8), (9), (10) (11), (12), (13), (14, (15), (16)
, (17), (18), (19), (20), (21), (22), (23), (24)
, (25), (26), (27), (28), (29), (30), (31), (32)
, (33), (34), (35), (36), (37) and (38).

(1) As for the fine powder of tea leaves, the dosage form is tablets, granules, capsules, powders, syrups (hereinafter abbreviated as tablets), or enteric coating with enteric coating on them. Formed into a tablet (hereinafter, abbreviated as tea leaf fine powder, or tablet) and administered orally, the tea leaf fine powder is placed inside the intestinal tract as a digestive organ, for example, As shown in the formulation table of Table 17 described above, enteric-coated tablets with enteric coating after tableting of 160 mg of tea leaf fine powder by weight are 8 mm in diameter. In the tablet of tableting fine powder of tea leaves with a diameter of 8 mm in the recipe shown in Table 17, the fine powder of tea leaves that adults usually drink is the amount of one cup. As a result, 0.3 g is sufficient, so about 1/2 cup of tea leaf fine powder is condensed inside the 8 mm diameter tablet. This diameter is 8m
If you take 4 tablets each time in the morning, noon and night, you will get 12
The total weight of tea leaves is 1.92 g. As the total amount of 1.92g tea leaves fine powder, 0.3g is enough for one cup for adults to drink, so 1.92g
The amount of fine tea leaf powder is comparable to that of about 6.4 cups of tea. When you become an elderly person by taking enteric-coated tablets of tableted tea leaf fine powder with a diameter of 50μm or less, the diameter of this tea powder fine powder is less than 50μm The purpose of waking up the sleepiness of an elderly person who is constantly drowsy, the purpose of waking up the sleepiness of a driver who is driving a car, or the purpose of waking up sleepiness while studying for an examination It is possible to suppress the onset of acute gastroenteritis that develops due to viruses or infectious diseases such as malaria. The purpose is to treat diabetes by lowering blood sugar levels,
By excretion of wastes such as fat inside blood vessels, there is an effect aimed at a therapeutic means for treating adult diseases such as hypertension by lowering blood pressure, anticancer, or hay fever. Also,
By using sugar, chocolate, cocoa, coffee or the like on the surface of the tablet described above as a sugar-coated tablet, the dosage can be further facilitated.
In addition, the antioxidants contained in the tea leaf powder contain a large amount of antioxidants such as beta-carotene, vitamin C, and vitamin E other than catechin. However, there is a calculation that the amount that adults take per day is dangerous if they take 150 g or more of fine powder of tea leaves per day.

(2) As described above, the tablet with the tea leaf fine powder tableted as described above is mainly used as a sugar-coated tablet, a cocoa-flavored sugar-coated tablet, a coffee-flavored sugar-coated tablet, or a chocolate-flavored tea. The shape of the dry-coated tablet, which is a double-structured tablet in the form of a dry-coated tablet using the tablet made of fine powder of leaves as the center of the dry-coated tablet, and using a tableting machine again By doing this, candy that contains a large amount of antioxidants such as catechin, beta-carotene, vitamin C, and vitamin E, which can be eaten by children and elderly people, is completed. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination The purpose of waking up sleepiness, or the effect is that a functional candy that can suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria is produced. In addition, for the purpose of treating diabetes by lowering blood glucose level, and by excreting waste products such as fat inside blood vessels, hypertension by lowering blood pressure, anticancer, or hay fever This has the effect of producing candy that is intended to treat adult diseases such as.

As for (3), in the case of forming chocolate for the purpose of awakening sleepiness using fine powder of tea leaves, for example, Tyrol Chocolate Co., Ltd., headquartered in Tagawa City, Fukuoka, is producing and selling When the product name is tyrol chocolate and the content is 10 g, the ratio of the fine powder of tea leaves to the weight of the tyrol chocolate content with respect to 10 g, for example, 0.001% or more, or 0.01% or more,
Or 0.05% or more, or 0.075% or more, or 0.1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0% or more, or 5.0% or more. Or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, or 15% or more Or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22% or more, or 23% or more, or 24% or more,
Or 25% or more, or 26% or more, or 27% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, or 40% or more, or 45% or more, or 50% or more, Or 60% or more, or 70% or more, or
80% or more, or 90% or more of tea leaf fine powder mixed with 10g of tyrol chocolate content of tea leaf fine powder, in proportion to the weight explained above, Forming tyrol chocolate, a chocolate that aims to wake up sleepiness, or to suppress the onset of infectious diseases such as acute gastroenteritis or malaria whose disease name is caused by influenza or rotavirus I can do it. Furthermore, for the purpose of treating diabetes by lowering blood sugar level, or by excretion of waste products such as fat inside blood vessels, such as hypertension by lowering blood pressure, anticancer, or pollinosis For example, tyrol chocolate is produced for the purpose of treating adult diseases.

(4) As described above, the product name is made of black chocolate or white chocolate (hereinafter abbreviated as chocolate) described above, and the product name is described inside the central portion of tyrol chocolate. A tablet in which a fine powder of tea leaves is tableted into a disc shape or a square shape in the shape of a meteorite is placed inside the central portion of tyrol chocolate, and this tea leaf fine powder is tableted Is the center of the dry-coated tablet, and the outer periphery of the tablet is made of tyrol chocolate (hereinafter abbreviated as “tyrol chocolate”). With the structure of a dry-coated tablet with a tablet inside the center part, for example, by forming tyrol chocolate, as explained above, people from children to the elderly can eat Catechin oxidants, beta-carotene, vitamin C, sweets is completed that contains large amounts of antioxidants such as vitamin E. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination The purpose of waking up sleepiness, or the effect is that a functional candy that can suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria is produced. Furthermore, for the purpose of treating diabetes by lowering blood sugar level, or by excretion of waste products such as fat inside blood vessels, such as hypertension by lowering blood pressure, anticancer, or pollinosis It has the effect of producing candy that is intended as a treatment for treating adult diseases.

(5) For the purpose of lowering blood glucose level, lowering blood pressure, or preventing or treating infectious diseases such as influenza, the raw materials are cocoa butter whole milk powder, vegetable oil and fat,
Minamata, reduced starch syrup, trehalose, cream powder, gelatin, wafer powder, powdered green tea, rice cake powder, cellulose, emulsifier (derived from soybean), gelling agent (pectin), and the outer peripheral part made from a brightening agent are chocolates. The portion is made of starch syrup, rice cake powder, for example, the name is tyrol chocolate with pure tea or baked rice, or with milk cream, or in the center of pumpkin pudding (hereinafter abbreviated, Mochi or fresh cream or pudding), the ratio of the tea powder to the weight, for example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more Or 0.1% or more,
Or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0%
Or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or
10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, or 15% or more, or 16
% Or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22%
Or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, or 40% Or more, 45% or more, or 50% or more, or 60% or more, or 70% or more, or 80% or more, or 90% or more of the fine powder of tea Put the inside of this rice cake with chocolate, for example,
Tyrolean chocolate, or Kitos Shoji Co., Ltd., located in Tokyo, is an importer from South Korea, the seller is Yayoi Co., Ltd., the producing country is South Korea, and the name of the tea is inside the coconut cake. The purpose of waking up sleepiness or the name of the disease is flu, or rota Tyrolean chocolate, which is chocolate aimed at suppressing the onset of acute gastroenteritis that develops due to viruses or infections such as malaria, can be formed. The purpose of treating diabetes by lowering blood sugar levels,
Or high blood pressure by lowering blood pressure by excreting waste products such as fat inside blood vessels,
Alternatively, there is an effect that, for example, a tyrol chocolate or a brand name coconut chocolate is aimed at a therapeutic means for treating an adult disease such as anticancer or hay fever.

As (6), in the same manner as described above, in the case of forming a chocolate plate having a desired plate shape for waking up sleepiness using a fine powder of tea leaves, for example, Meiji If the product name produced and sold by Confectionery Co., Ltd. is 58 g of black chocolate, and the product name produced and sold by Meiji Seika Co., Ltd. is 58 g of milk chocolate, or When Lotte Co., Ltd. manufactures and sells the product name Lotte Ghana's content is 60g (
(Hereinafter referred to simply as “plate chocolate”), the ratio of the amount of tea leaf fine powder mixed with 58 g or 60 g of the content of the plate chocolate is the same as in the case of the above-mentioned tyrol chocolate. For example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.
1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more,
Or 4.0% or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, Or 14% or more, or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more,
Or 22% or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, Or 40% or more, or 45% or more, or
50% or more, or 60% or more, or 70% or more, or 80% or more, or 90% or more of tea leaf fine powder and the amount of chocolate and tea leaf fine powder above the content of chocolate The purpose of awakening sleepiness by forming chocolate chocolate mixed at the rate explained in the above, or the onset of infectious diseases such as acute gastroenteritis or malaria caused by influenza or rotavirus It is possible to form a plate chocolate which is a chocolate intended to be suppressed. In addition, the purpose of treating diabetes by lowering blood glucose level, or by excreting waste products such as fat inside blood vessels, lowering blood pressure, or anticancer,
Alternatively, there is an effect that, for example, a plate-shaped plate chocolate is produced which is aimed at a therapeutic means for treating adult diseases such as hay fever.

As in (7), in the same manner as described above, in the case of forming a chocolate with the objective meteorite shape that uses the fine powder of tea leaves to wake up sleepiness, for example, Meiji Seika Co., Ltd. Furuta Confectionery Co., Ltd., headquartered in Osaka, has the same shape as the marble chocolate described above. If the product name is Wanage Chocolate and the content is 26 (
(Hereinafter, abbreviated as marble chocolate), the ratio of mixing fine powder of tea leaves with respect to the content of marble chocolate as in the case of the above-mentioned tyrol chocolate, for example, 0.001% or more, or 0.01% Or more, or 0.05% or more, or 0.075% or more, or 0.1% or more, or 0
.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0% or more,
Or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, Or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22% or more,
Or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 29% or more, or 30% or more, or 35% or more, or 40% or more, Or 45% or more, or 50% or more, or
60% or more, or 70% or more, or 80% or more, or 90% or more of tea leaf fine powder with respect to the content of marble chocolate, chocolate and tea leaf fine powder explained above The purpose is to wake up sleepiness, or to suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria. Marble chocolate, which is a processed chocolate, can be formed. Adults with high blood pressure, anticancer, or hay fever with the aim of lowering blood pressure by the purpose of treating diabetes by lowering blood glucose level or excreting waste products such as fat inside blood vessels For example, there is an effect that a marble chocolate or a tanner chocolate is produced for the purpose of treating a disease.

As for (8), the fine powder of tea leaves explained above has bitterness and astringency,
Because it is difficult to eat as a candy or candy, the outer periphery is mainly a tablet with tableted fine powder of tea leaves. For this purpose, a coated tablet on the surface of the tablet made mainly of fine tea leaf powder to form a sugar-coated tablet, or a tablet with a tablet using a tablet press again. The name of the product that Meiji Seika Co., Ltd. manufactures and sells is the shape of Marble Chocolate, or manufactured by Furuta Confectionery Co., Ltd. Tablets that are sold in the form of snail chocolate (hereinafter abbreviated as marble chocolate), and the outer periphery is chocolate and tableted with fine powder of tea leaves inside the center. Lock Double structure in the center as the center, for example, by making marble chocolate, antioxidant catechin, beta carotene, vitamin C, vitamin E, etc. that can be eaten by people from children to the elderly A candy containing a large amount of antioxidants is completed. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination The purpose of waking up sleepiness, or the effect is that a functional candy that can suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria is produced. further,
The purpose of treating diabetes by lowering blood glucose level, and adults such as high blood pressure, anticancer, or hay fever by lowering blood pressure by excreting waste products such as fat inside blood vessels For example, there is an effect that a marble chocolate or a tanner chocolate is produced for the purpose of treating a disease.

As for (9), when using a fine powder of tea leaves to form a candy for the purpose of waking up sleepiness, for example, a refreshing confectionery manufactured and sold by Morinaga Seika Co., Ltd., the main ingredient is glucose. , Tapioca starch, milk calcium and the product name is ramune, the content is 29g, the main ingredient in soft confectionery manufactured and sold by Kabaya foods headquartered in Okayama City is glucose,
The product name is made of sugar, cornstarch, and milk calcium.
In the case of abbreviated ramune or juicy C), the tea leaf fine powder is mixed with 29 g of ramune with an inner volume of 24 g or juicy C with a content of 24 g. The ratio to the weight is, for example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.
1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more,
Or 4.0% or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, Or 14% or more, or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more,
Or 22% or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, Or 40% or more, or 45% or more, or
50% or more, or 60% or more, or 70% or more, or 80% or more, or 90% or more of tea leaf fine powder inside the raw material of ramune or inside of the raw material of juicy C The purpose of waking up when forming ramune or juo C mixed with the powder in the proportion to the weight explained above, or acute gastroenteritis that develops due to influenza or rotavirus Or ramune or juicy C intended to suppress the onset of infectious diseases such as malaria. Also, for the purpose of treating diabetes by lowering blood sugar level, or by excreting waste products such as fat inside blood vessels, lowering blood pressure, anti-cancer, hay fever, etc. For example, there is an effect that a candy such as ramune or juicy C can be produced.

As (10), as described above, a confectionery for the purpose of waking up sleepiness using a fine powder of tea leaves may be formed by the following means. For example, centering on tablets made from fine powder of tea leaves, using the ingredients such as ramune explained above, or glucose, sugar, tapioca starch, corn starch, milk calcium, etc. The tablet of the outer peripheral part of the dry-coated tablet is formed, and the tablet in which fine powder of tea leaves is compressed inside the central part of the dry-coated tablet is placed inside the central part of the dry-coated tablet. Double structure
As a tablet raw material used for wrapping the outer periphery of the tablet with the center of the tablet having a tea leaf fine powder tableted inside the center of the tablet as the center of the dry tablet, for example, ramune, or By forming nucleated tablet tablets with double structure using raw materials of juo C, antioxidant catechin, beta carotene, vitamin C, vitamin E, etc. that can be eaten by everyone from children to the elderly A candy containing a large amount of antioxidants is completed. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination The purpose of waking up sleepiness, or the effect is that a functional candy that can suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria is produced. Furthermore, for the purpose of treating diabetes by lowering blood glucose level, or by excretion of wastes such as fat inside the blood vessels, high blood pressure by lowering blood pressure, anticancer, hay fever, etc. For example, there is an effect that a candy such as ramune or juicy C can be produced for the purpose of treating adult diseases.

(11) The main ingredients are gelatin, starch syrup, reduced starch syrup, sugar, and gummy candy (hereinafter abbreviated as gummy candy, or glutinous). The powder of tea was mixed and kneaded to form a fine powder of tea leaves in the gummy candy at a ratio to the following weight, mixed with fine powder of tea leaves, for example, 0.001% or more, Or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.1% or more, or 0
.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0% or more,
Or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, Or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22% or more,
Or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 29% or more, or 30% or more, or 35% or more, or 40% or more, Or 45% or more, or 50% or more, or
Eating gummy candy mixed inside the gummy candy with 60% or more, or 70% or more, or 80% or more, or 90% or more of tea leaf fine powder in proportion to weight,
The therapeutic means is intended to treat infectious diseases such as influenza and acute gastroenteritis, or adult diseases such as diabetes, hypertension, anticancer and hay fever.

As for (12), the main ingredients are gelatin, starch syrup, reduced starch syrup, sugar, and gummy candy (hereinafter referred to as gummy candy or glutinous). Put a tablet with tableted fine powder, and cover the outer periphery of tablet with tableted fine powder of tea leaves put in the center of gummy candy using gummy candy By eating the formed gummy candy, it is a therapeutic means aimed at treating infectious diseases such as influenza and acute gastroenteritis or adult diseases such as diabetes, hypertension, anticancer and pollinosis.

(13) As a main ingredient, gelatin, starch syrup, reduced starch syrup, sugar, and gummy candy (hereinafter referred to as gummy candy or rice cake) are mixed with tea leaves. A mixture of finely divided tea leaves, kneaded and then kneaded, the so-called gummy candy rice cake as the core of the central part, the outer periphery of this rice cake is white chocolate, black chocolate, or other mixture Chocolate with (
For example, the outer peripheral portion having a product name in the shape of tyrol chocolate is made of chocolate. This outer peripheral portion is made of chocolate and is formed by mixing and kneading the fine powder of tea leaves described above, and mixing the fine powder of tea leaves with respect to the following weight. Gummy candies or glutinous in all proportions mixed with tea leaves fine powder, for example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.1% or more, Or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0% or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, Or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, or 15% or more, or 16% or more, or 17% or more, or 18% or more, Or 19% or more
Or 20% or more, or 21% or more, or 22% or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 28% or more, or 29% or more, Or 30% or more, or 35% or more, or
40% or more, or 45% or more, or 50% or more, or 60% or more, or 70% or more, or 80% or more, or 90
The inside of the center part where the outer peripheral part is made of chocolate, which is a tentative name of gummy candy, in which fine powder of tea leaves is mixed with the fine powder of tea leaves in a proportion of weight. A gummy candy with a circular shape as a nucleus or a gummy candy with a square shape is put in, for example, the outer peripheral part with the shape of tyrol chocolate is chocolate, inside the gummy candy located in the central part of this chocolate Infectious diseases such as influenza and acute gastroenteritis by eating chocolate mixed with fine powder of tea leaves
Or it is set as the therapeutic means aiming at treating adult diseases, such as diabetes, high blood pressure, anticancer, and hay fever.

As for (14), the center part of the cocoa-flavored, chocolate-flavored, and coffee-flavored sugar-coated tablets coated on the surface of the tablets after tableting the fine powder of tea leaves into tablets. Formed into the shape of a tablet that is formed by compressing the fine powder of leaves, and the surface of this tablet is chocolate, for example, the product name is similar to marble chocolate, the outer periphery is formed using chocolate Infection of influenza, acute gastroenteritis, etc. by eating tablets with a sugar-coated tablet on the outer periphery of the tablet, with the tablet formed by squeezing tea powder as a core, Or treatment for the purpose of treating adult diseases such as diabetes, hypertension, anticancer and hay fever.

(15) As a raw material, chocolate is used to make a meteorite shape. For example, the product name is a disk shape made of marble chocolate. Infectious diseases such as influenza and acute gastroenteritis, or diabetes by eating tablets with a structure of dry-coated tablets that are tableted with fine powder of tea leaves on the outer periphery with a disc shape as the core It is a therapeutic means aimed at treating adult diseases such as hypertension, anticancer and hay fever. In addition, the core part of the central part, for example, chocolate made of disc-shaped chocolate is used as the core of the central part, and the outer peripheral part of the chocolate is tableted using fine powder of tea leaves. On the surface of the dry-coated tablet, the tea leaf fine powder is prone to oxidation and water absorption, so the tea leaf fine powder is made of tea leaf fine powder to prevent oxidation and water absorption. There is a need to coat the surface, which is the outer peripheral portion, to form a sugar-coated tablet.

(16) As an outer periphery using a tablet made of tea leaf fine powder, for example, a tablet having a disk shape as a core of the central portion, and a tablet tableted with this tea leaf fine powder as a core of the central portion Part
For example, using the name of the chocolate, which is the main ingredient of marble chocolate,
A tablet having a double-structured tablet having a tablet-shaped tablet structure in which a tablet obtained by tableting a fine powder of tea leaves is used as the core of the tablet and a peripheral part of the tablet is tableted using chocolate. By forming tablets whose main raw material was compressed using chocolate on the surface of the tablet tablets, a double structure that can prevent oxidation and water absorption, which are disadvantages of fine powder of tea leaves, was formed. A tablet with the structure of a dry-coated tablet is completed. Eating these double-structured tablets provides a therapeutic means for treating infectious diseases such as influenza and acute gastroenteritis, or adult diseases such as diabetes, hypertension, anticancer and hay fever.

(17) As an example, an outer peripheral portion having a tablet tableted with fine powder of tea leaves as the core of the center portion and a tablet tableted with fine powder of tea leaves as the core of the center portion, for example, a product Glucose, sugar, tapioca starch, corn starch, milk calcium, acidulant, emulsifier, fragrance, colorant, gelatin, and lake, etc., whose names are ramune or raw materials of juicy C Using the raw material forming C as a core of a tablet obtained by compressing fine powder of tea leaves, using the main raw material forming the outer periphery of the tablet as ramune or juicy C Then, a tablet with a double-layered structure of a dry-coated tablet in which a tablet at the outer peripheral portion was compressed,
The main raw material on the surface of the tablet of the dry-coated tablet is as described above. For example, by using the main raw material of ramune or juicy C to form a tablet by tableting, the disadvantage of tea leaves Thus, a tablet having the structure of a double-layered dry tablet capable of preventing oxidation and water absorption is completed. Eating these double-structured tablets provides a therapeutic means for treating infectious diseases such as influenza and acute gastroenteritis, or adult diseases such as diabetes, hypertension, anticancer and hay fever.

As (18), for example, Fujiya Co., Ltd. manufactures and sells tablets in which fine powder of tea leaves is compressed, and the brand name is Almond Chocolate, or Lotte Co., Ltd. The product name is the shape of the structure forming the chocolate with macadamia nuts. Almond, macadamia, or other nuts (hereinafter abbreviated as almond or macadamia) as the core of the central part, and the outer peripheral part with the central almond as the core is molded using chocolate. Instead of the almonds used in the chocolate with almonds or macadamia nuts chocolate (hereinafter abbreviated as almonds chocolate) with the structure covered and explained above, A tea leaf made by compressing a tea leaf fine powder into a core, and using a chocolate to cover the outer periphery of the tea leaf fine powder. A tablet with tableted fine powder of tea leaves is formed in the center of the core of the dry-coated tablet. Treatment for the purpose of treating infectious diseases such as influenza and acute gastroenteritis or adult diseases such as diabetes, hypertension, anticancer and hay fever by eating tablets whose outer periphery is made of chocolate Means.

(19) As described above, the name of the chocolate used in the chocolate with almonds or chocolate with macadamia nuts (hereinafter abbreviated as almond-containing chocolate) is contained in tea leaves. The ratio of the fine powder to the weight, for example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.1% or more,
Or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0%
Or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or
10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, or 15% or more, or 16
% Or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22%
Or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, or 40% More than, or 45% or more, or 50% or more, or 60% or more, or 70% or more, or 80% or more, or 90% or more fine powder of tea leaves in a ratio to the weight of chocolate and tea Using the chocolate mixed with the fine powder of the leaves, the fine powder of the tea leaves inside the chocolate covering the outer peripheral part of the almond-containing chocolate that forms the central part centered on the almond For the purpose of waking up by forming chocolate with almonds or chocolate with macadamia nuts using chocolate mixed at the rate described above, or the onset of the disease is caused by influenza or rotavirus Acute to do Enteritis, or suppressing the onset of infectious diseases such as malaria can be formed chocolate bar is a chocolate for the purpose of. Adults with high blood pressure, anticancer, hay fever, etc. that lower blood pressure by the purpose of treating diabetes by lowering blood sugar levels, or by excreting waste products such as fat inside blood vessels Therapeutic means intended to treat the disease.

(20) In the final stage of the manufacturing process of forming a rice cracker on the surface of a rice cracker, biscuit, and potato chips (hereinafter abbreviated as rice cracker or potato chips) In the stage where this rice cracker is made into a final product, the sugar content (hereinafter abbreviated as sugar or starch syrup, for the purpose of adhering fine powder of tea leaves on the surface of the plate-shaped rice cracker, Or sugar water in which fine powder of tea leaves is dissolved in sugar water in which sugar and sweetener are dissolved, For the purpose of spraying sugar water on the surface of the plate-shaped rice cracker, or using other processing means to adhere the fine powder of tea leaves onto the surface of the entire area of the plate-shaped rice cracker, The ratio of the fine powder of the leaf to the weight, for example, 0.001% or more, or 0. 01% or more, or 0.05% or more, or 0.075% or more, or 0.
1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more,
Or 4.0% or more, or 5.0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, Or 14% or more, or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more,
Or 22% or more, or 23% or more, or 24% or more, or 25% or more, or 26% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, Or 40% or more, or 45% or more, or
50% or more, or 60% or more, or 70% or more, 80% or more, or 90% or more of a fine powder of tea leaves in the form of a plate, which is the process of making a rice cracker in a ratio to the weight On the surface of the total area of
Spraying sugar water in which fine powder of tea leaves is dissolved, or using other processing means, adhere the fine powder of tea leaves to the surface of a plate-shaped rice cracker using sugar water. A large amount of antioxidants such as catechin, beta-carotene, vitamin C, and vitamin E, which can be eaten by children and elderly people, by forming candy sweets that are rice crackers, biscuits, and potato chips The confectionery, such as rice crackers, biscuits, and potato chips, is contained. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination Functional rice crackers, biscuits, and potato chips that can suppress the onset of drowsiness or the onset of acute gastroenteritis caused by influenza or rotavirus, or infection such as malaria It has the effect of making candy such as. Furthermore, for the purpose of treating diabetes by lowering blood sugar level, or by excretion of wastes such as fat inside the blood vessels, by reducing blood pressure, adult diseases such as hypertension, anticancer, hay fever etc. It has the effect of producing candy such as rice crackers, biscuits, and potato chips for the purpose of treatment.

(21) As a fine powder of tea leaves, cereals are formed on the surface of cereals (hereinafter abbreviated as corn or cereal) made of corn, wheat, rice, or other cereals. In the manufacturing process, for example, when corn is a raw material cereal, the corn is soaked in water to absorb the moisture, and then the corn is put on a roll, and pressure is applied from above and below to make the corn flat and then heated. And the cereal using the final product corn is completed. On the surface of the entire area of the corn having a flat plate shape at the stage of making this final product, the sugar content dissolved in an aqueous solution (hereinafter abbreviated,
Sugar dissolved in an aqueous solution for the purpose of adhering fine powder of tea leaves on the surface of the whole area of corn by spraying sugar, or starch syrup or sweetener) Tea leaves in which sugar powder in which fine powder of tea leaves is dissolved in water are sprayed on the surface of the flat corn, or dissolved in sugar water using other processing means For the purpose of adhering the fine powder of corn on the surface of the whole area of the corn having a flat plate shape, the ratio of the fine powder of tea leaves to the weight is, for example, 0.001% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or
2.0% or more, or 3.0% or more, or 4.0% or more, or 5.0% or more, or 6.0% or more, or 7.0% or more,
Or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more,
Or 14% or more, or 15% or more, or 16% or more, or 17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22% or more, or 23% or more, Or 24% or more, or 25% or more, or
26% or more, or 27% or more, or 28% or more, or 29% or more, or 30% or more, or 35% or more, or 40
% Or more, or 45% or more, or 50% or more, or 60% or more, or 70% or more, or 80% or more, or 90%
On the surface of the whole area of the flat corn, which is the process of producing cereals using corn, in the proportion of the above fine powder of tea leaves, the fine powder of tea leaves Sprayed with dissolved sugar water, or using other processing means, made of corn with a fine powder of tea leaves deposited on the surface of the whole area of flat corn using sugar water Cechin, beta carotene, vitamin C, vitamin E, etc. that can be eaten by children and elderly people by eating cereals made of wheat, rice, rice, or other grains A cereal or candy containing a large amount of antioxidants is completed. In addition, as explained above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an elderly person, the purpose of waking up the driver who is driving a car, or studying for an examination Functional cereals, potato chips, rice crackers, etc. that can suppress the onset of infectious diseases such as acute gastroenteritis caused by influenza or rotavirus, or malaria There is an effect that can be made. Furthermore, for the purpose of treating diabetes by lowering blood sugar level, or by excretion of wastes such as fat inside the blood vessels, by reducing blood pressure, adult diseases such as hypertension, anticancer, hay fever etc. Cereals, gummy candy, chocolate,
It has the effect of producing candy chips such as potato chips, rice crackers and bread.

As (22), in the same manner as described above, various kinds of confectionery such as gum, jasper, chocolate, biscuits, rice crackers, etc. are used for the purpose of waking up sleepiness using tea powder. A miscellaneous candy, or a confectionery such as a bun, or a cake, or a bread, or a bun, or a bun, or a bread used for a hamburger, or a bread used for a sandwich, or an octopus grilled powder, or an okonomiyaki powder, or a hot cake Of Korean food, Korean food Chijimi powder, Dango powder, Onigiri, Bento rice, or rice cake, or rice cake in rice cake, or rice cake in rice bun, or bread bun, or Chinese rice cake , Or moon cake, or rice cake in the middle,
Or rice cooked with castella, or rice, or white rice mixed with white rice, or white rice mixed with non-washed rice, or udon, or somen, or champon noodles, spaghetti, macaroni, buckwheat, or ramen, Or instant ramen, or baked buckwheat, or instant baked buckwheat, or milk shake, or ice cream, or ice candy, or pudding, or yogurt, or milk, or sheep carp, or caramel, gummy candy, or chewing candy, or drops Hereinafter, for the sake of brevity, fine powder of tea leaves is mixed in the inside of a candy, confectionery, bun, cake, bread, or other foods, drinking water, or alcoholic drinking water). For the purpose of waking up sleepiness, use fine powder of tea leaves as a candy The ratio of the weight to be mixed which inside, for example, 0.00
1% or more, or 0.01% or more, or 0.05% or more, or 0.075% or more, or 0.1% or more, or 0.25% or more, or 0.5% or more, or 1.0% or more, or 2.0% or more, or 3.0% or more, or 4.0% or more, or 5.
0% or more, or 6.0% or more, or 7.0% or more, or 8.0% or more, or 9.0% or more, or 10% or more, or 11% or more, or 12% or more, or 13% or more, or 14% or more, or 15% or more, or 16% or more, or
17% or more, or 18% or more, or 19% or more, or 20% or more, or 21% or more, or 22% or more, or 23
% Or more, or 24% or more, or 25% or more, or 26% or more, or 27% or more, or 28% or more, or 29%
Or more, 30% or more, or 35% or more, or 40% or more, or 45% or more, or 50% or more, or 60% or more, or 70% or more, or 80% or more, or 90% or more tea leaves It contains a large amount of antioxidants such as catechin, beta-carotene, vitamin C, and vitamin E, which are antioxidants that can be eaten by children and elderly people, by forming candy sweets mixed with fine powder A candy is made. In addition, as described above, the purpose of waking up the sleepiness of an elderly person who is constantly drowsy when becoming an old person, or the purpose of waking up the driver who is driving a car,
Or the purpose of waking up while studying for the exam, or a functional candy that can suppress the onset of acute gastroenteritis that develops due to influenza or rotavirus, or infectious diseases such as malaria There is an effect to be completed. Furthermore, for the purpose of treating diabetes by lowering blood sugar level, or by excretion of wastes such as fat inside the blood vessels, by reducing blood pressure, adult diseases such as hypertension, anticancer, hay fever etc. There is an effect that a candy for the purpose of treatment is completed.

(23) As a fine powder of tea leaves, for example, the trade name is Ramune, or the main ingredients of Juic C are glucose, sugar, tapioca starch, corn starch, milk calcium,
Tablets made by mixing sour seasonings, emulsifiers, flavorings, coloring agents, gelatin, pastes, etc. with fine powder of tea leaves and compressed into tablets, for example, the brand name is put in the center of tyrol chocolate In the central part of the chocolate, which is made up of gummy candy, or the brand name of Fujiya's almond chocolate, or Lotte's chocolate with macadamia nuts (hereinafter abbreviated as tyrol chocolate) Instead of the gummy candies, almonds, or macadamia nuts (hereinafter abbreviated as gummy candies), mix the fine powder of tea leaves in the proportions of the ingredients shown in Table 17. Tablets, or enteric coatings made from these tablets, or fine powder of tea leaves, and the main raw materials of ramune or juicy C, for example Catechin, beta-carotene, which is an antioxidant contained in the fine powder of tea leaves, for example, by forming tyrol chocolate, for example, by putting the tablet that has been mixed and compressed into the central part of tyrol chocolate, Because it contains a large amount of antioxidants such as vitamin E and vitamin C, it is a therapeutic means for treating infections such as influenza and acute gastroenteritis, or adult diseases such as diabetes and hypertension. For example, Tyrolean chocolate is completed. In addition, since it has an anticancer effect, for example, tyrol chocolate can be obtained as a therapeutic means for preventing and treating cancer. In addition, for example, tyrol chocolate, which is a therapeutic means for treating hay fever, is completed.

As for (24), the characteristics of green tea that constitutes the fine powder of tea leaves is that peroxidase, vitamin E, in the body to protect their leaves, which are green tea leaves, from lipid peroxides born by ultraviolet rays. It protects itself by producing carotenoids and vitamin C. Green tea contains a large amount of antioxidants such as catechin, beta-carotene, vitamin E, and vitamin C, which are antioxidants. However, since antioxidants are contained in the tea leaves themselves, which are green tea, and the tea liquid contains only a very small amount, the anti-oxidant substance is effective only for eating the green tea leaves that are the green tea leaves. It is not possible to consume large amounts of oxidants. Furthermore, in the case of catechins that contain green tea, catechins easily undergo a condensation reaction that binds to proteins, lipids, and sugar chains, so catechins that contain green tea are present in the stomach of the human body. Proteins, lipids,
And easily binds to sugar chains. The catechin compound in which this catechin is bound to protein, lipid, and sugar chain passes through the intestinal tract and is excreted from the large intestine, so catechin is absorbed into the human blood by the intestinal tract, the digestive organ of the human body The ratio of being used is extremely small. Therefore, the fine powder of tea leaves with a particle diameter of 50 μm or less, which is the fine powder of tea leaves, which is the object of the present invention, is passed through the stomach of the human body and passed through the stomach of the human body in the intestinal tract, the digestive organ. For the purpose of absorbing fine powder, fine powder of tea leaves is in the form of tablets, granules, capsules, powders, syrups, or enteric-coated enteric solvents (hereinafter abbreviated as tablets, Or catechin tablets, or enteric solvent), by orally administering enteric solvent made of fine powder of tea leaves,
The enteric solvent does not dissolve in the stomach but passes through the stomach and dissolves in the intestinal tract, which is the digestive organ. By ingesting the fine powder of tea leaves forming the intestinal solvent dissolved inside this intestinal tract into the blood of the human body and decomposing the fine powder of tea leaves in the liver and kidney Since the body produces a large amount of antioxidants such as catechin, beta-carotene, vitamin E, and vitamin C, which are antioxidants contained in tea powder, influenza, acute gastroenteritis, etc. It is a therapeutic means aimed at treating adult diseases such as diabetes and hypertension. In addition, since it has an anticancer effect, it is a therapeutic means for the purpose of preventing and treating cancer. Furthermore, it becomes a therapeutic means for the purpose of treating adult diseases such as pollinosis.

As for (25), it is a substance called an antigen contained in pollen that causes hay fever. When this antigen enters the human body, the immune response becomes excessive, causing runny nose and sneezing,
My eyes become itchy. A substance similar to the antigen of cedar pollen, which is the causative substance of this hay fever,
It is contained in a very small amount of tea powder, which is green tea.

As for (26), an antigen similar to the antigen of cedar pollen, which is a causative agent of pollen allergy contained in the fine powder of tea leaves, is taken into the human body to produce antibodies in the human body. As a treatment for the purpose of treatment of desensitization therapy that suppresses the immune response of the human body by accustoming to, tablets made of tea leaf fine powder or tea leaf fine powder Or, catechin tablets or intestinal solvents are taken orally and ingested, and a substance similar to cedar pollen that causes pollinosis is taken into the body, so an antigen similar to the antigen of cedar pollen Will be produced in the human body, and the human body itself will suppress and suppress the symptoms of hay fever by its own immune reaction. From this, the fine powder of tea leaves is in the form of tablets, granules, capsules, powders, syrups (hereinafter abbreviated as fine powder of tea leaves, tablets, catechin tablets, or enteric solvents). ), Or by taking enteric coatings with enteric coatings on them, the human body will produce antibodies against antigens similar to those of cedar pollen. The immune reaction will suppress and suppress the symptoms of hay fever. As a result, it becomes a therapeutic means that reduces symptoms such as runny nose, sneezing and itchy eyes, or completely suppresses symptoms.

(27) As described above, at the stage of making tea leaves fine powder, or tea leaves that are green tea (hereinafter abbreviated as tea leaves fine powder or green tea) Using a coating material (hereinafter abbreviated as HPMCP) for the purpose of surface treatment as hybromellose phthalate ester, zein, shellac, or other enteric solvent in the stage, green tea Enteric coating as an enteric solvent using HPMCP on the surface of leaves, or enteric coating processing by infiltrating HPMCP on the surface of green tea leaves and inside the green tea leaves Using green tea as a raw material, green tea leaves are made into enteric solvent properties, and then green tea leaves that are tea leaves are used to form fine tea leaf powder, or green tea is made into fine powder,
Using the tea leaf fine powder that was enteric coated using HPMCP at the tea leaf fine powder stage, the dosage forms described above are tablets, granules, capsules, powders. When a syrup (hereinafter abbreviated as tea leaf fine powder, or tablet or catechin tablet) is formed, the tea leaf fine powder that has been enteric coated using HPMCP to the inside of the tablet Since tablets are formed in the form of tablets, it is possible to form tablets that are tableted with fine powder of tea leaves that are effective as an intestinal solvent even if the tablets are chewed inside the mouth when taking the tablets. Because you can
It is ideal as a candy for children, infants and the elderly. In addition, it can be used as various miscellaneous treatment means. Furthermore, enteric coating processing using HPMCP at the green tea leaf stage or tea leaf fine powder stage, the human body directly drinking tea leaf fine powder as tea The digestion and absorption of the tea leaves in the intestinal tract through the stomach without digesting the tea leaves in the stomach, the digestive organ of the human body The purpose is to drink a fine powder of tea leaves. However, he drinks just as he does traditional tea. However, the difference between the conventional method of drinking tea and the method of drinking tea with HPMCP processed enteric coated tea is different from the method of drinking tea. Drinking tea is a different point from drinking traditional tea. In addition, HPMCP is the raw material that can be put inside candy
As described above, the fine powder of tea leaves that have been enteric-coated using cereals have excellent functional properties, so it can eradicate human lifestyle-related diseases. There is.

(28) includes rooibos tea, mangroves, pine nut shells, green tea, tea, pigeon tea, barley tea, brown rice tea, oolong tea, puer tea, or other herbal tea Or coffee, or dry wood tree chips, or cherry tree chips, or apple tree chips, beech tree chips, oak tree chips, or walnut tree chips Or Hickory wood chips, or maple wood chips, or mixed wood chips such as birch trees, cherry trees, beech trees, oak trees, maple trees, or birch tree chips, Or other wood chips, green tea, black tea, chlorella, chlorella tea, Tochu tea, barley tea, brown rice tea, coffee, cocoa, octagonal fine powder, pine nut powder, mangrove trunk and branches and leaves Powder, rose tea, strawberry genus tea, yellow tea (pai tea), cat claw (cat crow tea), kuzuka tea, tahibo tea native to the Amazon , Rooibos tea from Africa, eye-drop tree tea (Megsurinoki tea), Gymnema tea from India, Rafu hemp tea, cod leaf tea, Iperosho tea, Umeyama Shusui tea, Propolis tea, Ganoderma tea, Chitosan tea, Sashigo Kacha (Yoseju tea), Fucha tea (Puer tea),
Turmeric tea, carrot tea, dokudami tea, tomorrow leaf tea (Ashitaba tea), candy tea tea (Amacha tea tea)
, Aloe tea, Ginkgo leaf tea, Oolong tea, Psyllium tea, Oyster leaf tea, Garcinia tea, Gymnema tea, Guava tea, Moku tea, Kumazasa tea, Mulberry leaf tea, Sijuum tea, Perilla leaf tea, Jasmine tea, Sugina Tea, buckwheat tea, tabebuiya tea, cod leaf tea, ten tea, dokudami tea, herb tea, ning tea (ninhong tea), pearl barley tea, banaba tea, hub tea, loquat tea, ratio tea (Pei Chi tea), Mate Tea, Umeyama Shusui Tea, Eucalyptus Tea, Mugwort Tea, Rakanka Tea, Raffma Tea, Ryui Tea (
Longines tea), or ginseng, licorice, citrus yellow, jujube, or Chinese herbal medicine, kakkon, toki, peony, ginger, ginseng (
Koboku), Rokujou, or Chinese herbal medicine, Bushi, Hange, Daio, Kyonin (hereinafter abbreviated as grass root bark, or herbal medicine, or rooibos tea) , Green tea, sencha, bancha, strawberry tea, oolong tea, puer tea, black tea), as described above, for example, at the stage of fine powder of tea leaves that are green tea, hybromellose phthalate (Hereinafter abbreviated as HPMCP), or zein, shellac, or other enteric coating materials (hereinafter abbreviated as HPMCP) to dissolve and absorb in the intestinal tract, the digestive tract. The enteric coating process is performed on the surface of the fine powder of tea leaves using an enteric coating material such as HPMCP. Or, at the stage of green tea leaf, which is the raw material of fine powder of tea leaves, on the surface of the green tea leaf and for the purpose of dissolving and absorbing in the intestinal tract, the digestive organ HPMC inside the leaf
Enteric solvent using enteric coating materials such as HPMCP, using green tea leaves that have been enteric coated using P etc. as raw materials using grinding means such as stone mill, ball mill, jet mill etc. The green tea leaves with enteric coating for fine powder, and the powdered form of tea leaves are tablets, granules, capsules, powders, syrups (hereinafter abbreviated as tea A fine powder of leaves, or tablets, or catechin tablets, or enteric solvents).
Alternatively, enteric coated materials using an enteric coating material such as HPMCP on the surface again are tablets, granules, capsules, powders, syrups (hereinafter abbreviated as tea leaves). Infectious diseases such as influenza, acute gastroenteritis, malaria, AIDS, sleeping sickness, etc. using intestinal solvent in the form of fine powder, or tablet, or catechin tablet, or enteric solvent)
Therapeutic means for preventing and treating adult diseases such as diabetes, hypertension, anti-cancer, and hay fever, and the raw material of the drug.

(29) As described above, enteric coating is performed using an enteric coating material such as HPMCP at the stage of fine powder of tea leaves as described above. Or the surface of the green tea leaves intended to be dissolved and absorbed in the intestinal tract, the digestive organ at the stage of the green tea leaves, which are the raw materials of the tea powder, and the green tea leaves Inside, green tea leaves that have been enteric coated using HPMCP or the like are used as raw materials, and grinding means such as stone mills, ball mills, jet mills, etc., and green tea leaves are used enteric coating materials such as HPMCP. The green tea leaves formed for the purpose of acting as an enteric solvent are fine powders, the tea leaf fine powders are cereals, chocolates, potato chips, rice crackers, breads, etc.
Various miscellaneous candy such as jasper, chocolate, biscuits, rice crackers, or confectionery such as buns,
Or cake, bread, cake bread, cake bread, bread for hamburgers, bread for sandwiches, bread for sandwiches, octopus grilled powder, okonomiyaki powder, hot cake powder, or Korean food chijimi powder , Or dumplings, or onigiri, or rice in a lunch box, or rice cake, or rice cake in a rice cake, or rice cake in a bun, or rice cake in an bun, or a Chinese rice cake or moon cake, or in the middle Rice cooked with rice cake, castella, rice, white rice mixed with white rice, or white rice mixed with non-washed rice, or udon, or somen, champon noodles, spaghetti, macaroni, buckwheat, Or ramen, or instant ramen, or baked buckwheat, or instant baked buckwheat, or milkshake,
Or ice cream, ice candy, pudding, yogurt, milk, sheep goat, caramel, gummy candy, chewing candy,
Or drops, or other foods, or drinking water, or alcoholic drinking water (hereinafter abbreviated as candy, or confectionery, or wharf, cake, or bread, or other foods, drinking water, or alcoholic beverages) In the inside of the water), tea leaf fine powder is mixed, and as explained above, infections such as influenza, acute gastroenteritis, malaria, AIDS, sleeping sickness, or diabetes, hypertension, It is used as an additive for forming functional candy for the purpose of preventing and treating adult diseases such as anticancer and hay fever. It is also a health supplement.

As for (30), using the enteric coating material such as HPMCP for the green tea leaves described above, the surface of the green tea leaves was used as an enteric solvent with enteric effects for the purpose of action and effect. When forming fine powder of tea leaves, it is the stage of green tea leaves, which are raw materials for fine powder of tea leaves,
HPMCP at the stage of flat tea leaves after steamed with steam and dried tea leaves that are intended to form matcha tea Enteric coating material for the enteric solvent is used by infiltrating the enteric solvent on the surface of the tea leaf and inside the tea leaf using an enteric coating material such as Tea leaves, for example, the diameter is 0.5 mm x 0.5 mm or less, or 1 mm x 1 mm or less, or 2 mm x 2 mm or less, or 3 mm x 3 mm or less, or 4 mm x 4 mm or less, or 5 mm x 5 mm or less, or 10 mm x 10mm or less, or 15mm
After cutting to 15mm or less, or 20mm x 20mm or less, or 20mm x 20mm or more,
Additives to food and health without making fine powder of green tea leaves that have been enteric-coated on the surface of tea leaves and into the inside of tea leaves, and have been enteric coated for enteric solvent It is effective as a supplement, pharmaceutical raw material, and pharmaceutical. In addition, as described above, by using enteric coating processing for enteric solvent as an additive or as a raw material for green tea leaves subjected to enteric coating processing, As explained
Influenza such as influenza, acute gastroenteritis, malaria, AIDS, sleeping sickness, or diabetes,
Drinking water that is tea in a functional plastic bottle for the purpose of preventing and treating adult diseases such as high blood pressure, anticancer, hay fever, or soft drink in the same plastic bottle,
Alternatively, various miscellaneous alcoholic beverages such as beer, sake, shochu, whiskey, wine, liqueur and other alcoholic beverage additives or raw materials can be formed.

As for (31), using the enteric coating material such as HPMCP for the green tea leaves described above, the surface of the green tea leaves was used as an enteric solvent having enteric effects, and the effect was aimed When forming fine powder of tea leaves, it is the stage of green tea leaves, which are raw materials for fine powder of tea leaves,
HPMCP at the stage of flat tea leaves after steamed with steam and dried tea leaves that are intended to form matcha tea Enteric coating material for the enteric solvent is used by infiltrating the enteric solvent on the surface of the tea leaf and inside the tea leaf using an enteric coating material such as Tea leaves, for example, the diameter is 0.5 mm x 0.5 mm or less, or 1 mm x 1 mm or less, or 2 mm x 2 mm or less, or 3 mm x 3 mm or less, or 4 mm x 4 mm or less, or 5 mm x 5 mm or less, or 10 mm x 10mm or less, or 15mm
After cutting to 15mm or less, or 20mm x 20mm or less, or 20mm x 20mm or more,
Crushing means such as a stone mill, ball mill, jet mill, etc., after intestinal solvent is infiltrated on the surface of tea leaves and inside the tea leaves, and enteric coating processing for enteric solvent is performed If the fine particle of tea leaves having a particle diameter of 50 μm or less, or 50 μm or more is formed using this, it is possible to form a tea leaf fine powder that has a more enteric effect. It is effective as a food additive, health supplement, pharmaceutical raw material, and pharmaceutical.

As for (32), about 1 million infants and children die from acute gastroenteritis per year in the equator zone. As a therapeutic means to prevent and treat viruses such as rotavirus and norovirus, which are the causative viruses that cause this acute gastroenteritis, at the stage of flat tea leaves explained above inside the syrup solution Using a enteric coating material such as HPMCP, fine powder of tea leaves with a particle diameter of 50 μm or less, or 50 μm or more, intended for enteric solvents, is mixed into the syrup solution. Rotavirus, norovirus that grows in the intestinal mucosa of the intestinal tract using a mixed syrup solution (hereinafter abbreviated as syrup) mixed with tea leaf fine powder Acute gastroenteritis that develops due to viruses such as rotavirus, norovirus, etc. by oral administration of syrup mixed with fine powder of tea leaves for enteric solvent Prevention aimed at inactivating the cause viral enteritis, and a treatment means for the purpose of treatment.

The purpose of (33) is to use the enteric coating material such as HPMCP for the green tea leaves described above, and to act as an enteric solvent that has an enteric effect on the surface of the green tea leaves. did,
When forming tea leaf fine powder, tea leaves in a state intended to form green tea, which is the stage of green tea leaf, which is the raw material of tea leaf fine powder, for example, raw tea leaves After the tea leaves have been steamed and dried using steam, enteric coating materials such as HPMCP are used at the tea leaf stage in a flat state, and on the surface of the tea leaves and of the tea Enter the inside of the leaves with enteric solvent, enteric coating processing for enteric solvent, or flat tea leaves, for example, 0.5mm x 0.5mm or less, or 1mm x 1mm in diameter Or less, or 2 mm x 2 mm or less, or 3 mm x 3 mm or less, or 4 mm x 4 mm or less, or 5 mm x 5 mm or less, or 10 mm x 10 mm or less, or
After cutting to a size of 15 mm x 15 mm or less, or 20 mm x 20 mm or less, or 20 mm x 20 mm or more, infiltrate the enteric solvent on the surface of the tea leaf and inside the tea leaf, After the desired enteric coating process, the tea leaves are pulverized using a grinding tool such as a stone mortar, ball mill, jet mill, etc., so that the diameter of the tea leaves is 50 μm or less, or 50 μm or more. Powdered tea leaf powder is dried in drinking water, soft drinks, alcoholic beverages, for example, inside tea bags for the purpose of extracting tea and drinking tea, or in other containers As a fine powder of tea leaves in the state, or as a fine powder of tea leaves to be placed in an aqueous solution for the purpose of extracting tea to be put in the inside of a PET bottle As a fine powder of tea leaves Or as a fine powder of tea leaves for the purpose of extracting tea to be placed in alcoholic beverages such as beer, sake, shochu, whiskey, wine, liqueur, etc., which are alcoholic beverages. The surface of the green tea leaves at the leaf stage or the green tea, bancha, sencha, matcha tea (hereinafter abbreviated as green tea), which are generally commercially available tea leaves that are the final products of green tea. HP on top or inside green tea leaves
Green tea infiltrated with enteric coating material such as MCP is crushed, and the particle size of green tea is 50
As described above, as an additive or as a raw material for drinking water, soft drinks, alcoholic beverages mixed with fine powder of tea leaves of 50 μm or less, or 50 μm or more Put in a functional plastic bottle to prevent and treat adult diseases such as diabetes, hypertension, anti-cancer, hay fever, or infectious diseases such as acute gastroenteritis, malaria, AIDS, sleeping sickness Beer, sake, shochu, whiskey, wine, soft drinks, or soft drinks in a plastic bottle, or miscellaneous alcoholic drinks
Additives for alcoholic beverages such as liqueurs, or raw materials can be formed.

(34) is a raw material for the purpose of forming fine powder of tea leaves, the size is 2mm
5mm from the leaf stage of tea (hereinafter abbreviated as green tea), hybromellose phthalate (hereinafter abbreviated as HPMCP), or twein or shellac (hereinafter abbreviated as HPMCP) And enter the enteric coating material on the surface of the green tea leaf using the enteric coating material and the inside of the green tea leaf, and on the surface of the green tea leaf and inside the green tea leaf Using enteric coating materials such as HPMCP, green tea leaves are enteric coated and dissolved in the intestinal tract without being digested in the stomach, the digestive organ, and taken into the body. The purpose of this is to administer the green tea leaves that have been processed for the purpose of intestinal solvent orally, and infectious diseases such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia,
Or adult diseases such as diabetes, hypertension, anticancer, hay fever, or functional foods such as cereals, chocolate, gummy candy, potato chips, rice crackers, and bread, or drinking water,
Adhering green tea leaves that have undergone enteric coating processing inside carbonated drinking water, alcoholic drinking water (hereinafter abbreviated as candy), and forming mixed candy and treating infectious diseases and adult diseases The therapeutic means is intended to treat.

(35) is a raw material for the purpose of forming fine powder of tea leaves, the size is 2mm
5mm from the leaf stage of tea (hereinafter abbreviated as green tea), hybromellose phthalate (hereinafter abbreviated as HPMCP), or twein or shellac (hereinafter abbreviated as HPMCP) And enter the enteric coating material on the surface of the green tea leaf using the enteric coating material and the inside of the green tea leaf, and on the surface of the green tea leaf and inside the green tea leaf Using enteric coating materials such as HPMCP, green tea leaves are enteric coated and dissolved in the intestinal tract without being digested in the stomach, the digestive organ, and taken into the body. For the purpose, the green tea leaves after processing for enteric solvent were used to make the dosage form into tablets, granules, capsules, powders, syrups, or enteric coating again. Enteric solvent (hereinafter abbreviated, Tea leaf fine powder, or tablet, or catechin tablet, or enteric solvent) orally administered to infectious diseases such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia, or diabetes, hypertension, Therapeutic means aimed at treating adult diseases such as anticancer and hay fever.

(36) is a raw material intended to form a tea leaf fine powder, which is a hybromellose phthalate ester (hereinafter abbreviated) at the tea leaf stage (hereinafter abbreviated as green tea). ,
HPMCP), or twein or shellac (hereinafter abbreviated as HPMCP) and other enteric coating materials are used to penetrate the green tea leaf surface and into the green tea leaf Let the green tea leaf surface and the inside of the green tea leaf enteric coating material such as HPMCP, enter the green tea leaf enteric coating processing inside the stomach that is the digestive organ For the purpose of dissolving in the intestinal tract and ingesting it without digestion, the green tea leaves after processing for the purpose of intestinal solvent are crushed using a mill, ball mill, jet mill, etc. Oral administration of tea leaf fine powder with a particle size of 50 μm or less, or a particle size of 50 μm or more, orally infectious diseases such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia, or Diabetes, high blood pressure , Anti-cancer, adult diseases such as hay fever, or functional foods such as cereal, chocolate, gummy candy, potato chips, rice crackers, bread, or drinking water, carbonated drinking water, alcoholic drinking water (hereinafter abbreviated) The treatment means to treat infectious diseases and adult diseases by adhering fine powder of tea leaves that have undergone enteric coating to the inside, and forming mixed candy And

(37) As a raw material intended to form fine powder of tea leaves, at the stage of tea leaves (hereinafter abbreviated as green tea), hybromellose phthalate (hereinafter abbreviated as “green tea”). ,
HPMCP), or twein or shellac (hereinafter abbreviated as HPMCP) and other enteric coating materials are used to penetrate the green tea leaf surface and into the green tea leaf Let the green tea leaf surface and the inside of the green tea leaf enteric coating material such as HPMCP, enter the green tea leaf enteric coating processing inside the stomach that is the digestive organ For the purpose of dissolving in the intestinal tract and ingesting it without digestion, the green tea leaves after processing for the purpose of intestinal solvent are crushed using a mill, ball mill, jet mill, etc. Using a fine powder of tea leaves with a particle size of 50 μm or less, or a particle size of 50 μm or more, the dosage form is a tablet, granule, capsule, powder, syrup, or again, Enteric coating processed enteric coating Infections such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, and adult leukemia by oral administration of an agent (hereinafter abbreviated as tea leaf fine powder, tablet, catechin tablet, or enteric solvent) Or therapeutic means aiming to treat adult diseases such as diabetes, hypertension, anticancer, hay fever.

As (38), enteric coating processing is performed using the above-described fine powder of tea leaves using HPMCP, zein, or shellac (hereinafter abbreviated as zein or shellac). Orally administer a fine powder of tea leaves as an enteric solvent orally,
Or cocoa, cocoa butter, cacao mass, whole milk powder, whey powder, skimmed milk powder, vegetable oils and fats for the purpose of eating to lower blood sugar levels, to lower blood pressure, or to prevent or treat infectious diseases such as influenza. Chickenpox, reduced starch syrup, trehalose, cream powder,
Gelatin, wafer powder, rice cake powder, cellulose, emulsifier (derived from soybean), gelling agent (
Pectin), brightener, and fragrance as a raw material, the outer peripheral part is made of chocolate, the central part is made of starch syrup and mochi flour, the central part is made of mochi, and the outer peripheral part is made of chocolate. The purpose of reducing the blood sugar level by mixing the fine powder of tea leaves in the inside of the glutinous rice mixed in the central part of the structured chocolate, or reducing the blood pressure,
Or it is set as the therapeutic means for the purpose of preventing and treating infectious diseases such as acute gastroenteritis that develops due to influenza or rotavirus.

Furthermore, the tea leaves that are the raw material of the tea leaf fine powder or tea leaf fine powder described above (hereinafter abbreviated as tea leaf fine powder or green tea). When describing the enteric coating material used for the purpose of using enteric solvent as an enteric solvent, the hybromellose phthalate ester (hereinafter abbreviated as HPMCP) described first is the enteric coating exclusively for pharmaceuticals. It is a coating material. Secondly, the trade name Twein is manufactured and sold by Kobayashi Fragrance Co., Ltd., headquartered in Tokyo. Twein's raw material is a protein made of corn-derived raw material. The main purpose of use of this twein is quasi-drug and its use is limited to foods or health supplements and pharmaceuticals. Thirdly, the product name Shellac is manufactured and sold by Nippon Shellac Industry Co., Ltd., headquartered in Osaka. The raw material for shellac is a resin collected from the shellfish that live in Southeast Asia, especially in India, Thailand, Indochina, etc. The main purpose of use of this shellac is quasi-drug as well as twein, and its use is limited to food, health supplements, and pharmaceuticals. However, what is common to twein and shellac is an enteric coating material produced in nature, unlike chemically synthesized HPMCP, which is a substance that has no side effects and no toxicity. Further, as an advantage of twein and shellac, since there is no scent, smell or taste, it is also an enteric coating material having an effect that does not affect the taste of the material. In addition, HPMCP is excellent as an enteric coating material, so HPMCP is an enteric coating material having an action effect depending on the purpose of use.

Masaru Yotsuka, who lives in Mada, 336, Amagi City, Fukuoka Prefecture, is 60 years old and is about 12 years old.
Diabetes patient for about a year. The clinic where Mr. Masaru Yotsusho visits is Ogawa Internal Medicine, which is open in Amagi City, and has been in Ogawa Internal Medicine for about 12 years. At Ogawa Internal Medicine, blood hemoglobin HbA1C is tested every month as a test for diabetes. Test results of hemoglobin HbA1C in blood, which is a test for diabetes, are shown in the following (1), (2), (3)
, (4), (5), and (6).

The test results of hemoglobin HbA1C in the blood of Mr. Masaru Yossho explained above are as follows.

(1) The value of hemoglobin HbA1C tested for diabetes on January 21, 2009 is 6.5.
%Met.

(2) The value of hemoglobin HbA1C tested for diabetes on April 17, 2009 was 6.5.
%Met.

(3) The value of hemoglobin HbA1C tested for diabetes on June 16, 2009 was 8.1%
Met.

(4) The value of hemoglobin HbA1C tested for diabetes on October 20, 2009 is 5
It was .7%.

(5) The value of hemoglobin HbA1C tested for diabetes on November 6, 2009 is 5.7.
%Met.

(6) The value of hemoglobin HbA1C tested for diabetes on November 24, 2009 is 5
It was .7%.

(7) The value of hemoglobin HbA1C tested for diabetes on December 22, 2009 is 5
It was .8%.
Furthermore, the explanation of the test results of hemoglobin HbA1C in the blood of Mr. Masaru Yossho explained above, the test results of hemoglobin HbA1C of Mr. Masaru Yossho are as follows: , 6.5% which is the result of the test conducted on January 21, 2009 and 6.5% which is the result of the test conducted on April 17, 2009, which is explained above.
The results of the test conducted on March 16th, 8.1%, and hemoglobin HbA from Mr. Masaru Yotsusho for the past 12 years
The test result of 1C was a numerical value of blood sugar level exceeding the appropriate range of 4.3% to 5.8%.
According to the test results conducted on the 20th of the month, the test result of hemoglobin HbA1C was decreased to 5.7%, which is within the range of normal appropriate values, in the test result of hemoglobin HbA1C.

In addition, the test result of November 6, 2009 shows that the test result of hemoglobin HbA1C is 2.
It is exactly the same as the test result conducted on October 20, 009, and is within the range of normal aptitude value.
The test result of hemoglobin HbA1C decreased to 7%.

Furthermore, the hemoglobin HbA1C performed on November 6, 2009, which was 17 days after the test result of hemoglobin HbA1C performed on October 20, 2009 was 5.7%.
The result of this test was maintained at 5.7%, exactly the same as the test result of hemoglobin HbA1C conducted on October 20, 2009.

Moreover, the reason why the test result of hemoglobin HbA1C described above has decreased to 5.7% is as follows. From October 8, 2009, the diameter shown in the composition table of Table 17 is 8 mm. Before taking meals three times a day, four tablets with an 8mm diameter were taken by oral administration, and the blood glucose level of Mr. Masaru Yosho decreased almost 100%. I can do it.

In addition, one month after the HbA1C test result on October 20, 2009,
Since the test result of hemoglobin HbA1C conducted on January 24 was maintained at 5.7% within the range of appropriate values, the substances listed in Table 17 are not toxic and have no side effects. It is a fine powder of leaves. On the surface of the uncoated tablet obtained by compressing the fine powder of tea leaves, using the bromellose phthalate ester (hereinafter abbreviated as HPMCP) which is a coating material shown in Table 17 For the purpose of treating diabetes by reducing the blood glucose level, the tablet made of enteric solvent by coating the surface of the uncoated tablet is as a means of treating diabetes because the fine powder of tea leaves has no toxicity or side effects. Is a magic bullet aimed at the most optimal treatment for diabetes.

In addition, the result of the hemoglobin HbA1C test conducted on December 22, 2009 increased to 5.8%. Judging from the events in December by Mr. Masaru Shijosho, many events such as the year-end party were held and alcohol was consumed. It can be judged that the increased amount of alcohol consumed is the reason why the test result of Masayoshi Yossho's hemoglobin HbA1C rose to 5.8%.

Furthermore, although the test result of hemoglobin HbA1C performed on December 22, 2009 had risen to 5.8%, the blood glucose level of Mr. Masaru Yosho was within the appropriate range of 4.3% to 5.8%. The tablets made from enteric coating using HPMCP on the surface of the uncoated tablets made from fine powder of tea leaves were judged to be effective in reducing blood sugar levels. I can do it.

In addition, the above-described enteric coating material HPMCP, or zein, or shellac (hereinafter abbreviated as HPMCP, zein, or shellac) has a highly acidic PH concentration as a digestive organ. It does not dissolve in a certain gastric juice, but dissolves in the digestive fluid of the intestinal tract, which is a digestive organ with a strong alkaline pH. Using the properties of HPMCP, or twein, or shellac, enteric coating processing is performed using enteric coating material such as HPMCP, twein, or shellac at the stage of fine powder of tea leaves. Or the surface of the green tea leaves intended to be dissolved and absorbed in the intestinal tract, the digestive organ at the stage of the green tea leaves, which are the raw materials of the tea powder, and the green tea leaves Inside,
Using green tea leaves that have been enteric coated using HPMCP, Twein, shellac, etc. as raw materials, using green powder such as a stone mill, ball mill, jet mill, etc. Green tea leaves formed for the purpose of acting as an enteric solvent using fine powder, tea leaf fine powder with cereals, chocolate, potato chips, rice crackers, bread etc. A variety of miscellaneous candy such as gum, jasper, chocolate, biscuits, rice crackers, or confectionery such as a bun, or cake, or bread, or confectionery bread, or bread for hamburgers, or bread for sandwiches , Or octopus grilled powder, okonomiyaki powder, hot cake powder, Korean food chijimi powder, dango powder , Or onigiri, rice for lunch, or rice cake, or rice cake in a rice cake, rice cake in a rice bun, rice cake in an bun, Chinese rice cake, moon cake, rice cake in the middle, or castella , Or rice cooked with rice, or white rice mixed with white rice, or white rice mixed with non-washed rice, or udon, or somen, or champon noodles, spaghetti, macaroni, buckwheat, ramen, or instant ramen,
Or baked buckwheat, or instant baked buckwheat, or milk shake, or ice cream, or ice candy, or pudding, or yogurt, or milk, or mutton, or caramel, gummy candy, or chewing candy, or drops, or other food Or drinking water or juice or milk shake or amazake or alcoholic drinking water (hereinafter abbreviated as candy, or confectionery, or bun, or cake, or bread, or other food, or drinking water, or Juice, soft drinks, amazake, or miscellaneous alcoholic drinks such as beer, sake, shochu, whiskey, wine, liqueur, etc.) Mix green tea leaves and A functional candy intended to prevent and treat enza, acute gastroenteritis, infectious diseases such as malaria, AIDS, sleeping sickness, or adult diseases such as diabetes, hypertension, anticancer, hay fever, or Let it be an additive for forming drinking water, soft drinks, juice, milk shakes, amazake, or alcoholic drinks. It is also a health supplement.

Furthermore, as a cause of diabetes, basically, a disease caused by a difference between calorie intake and calorie consumption consumed by the human body is diabetes. In short, diabetes is a disease caused by ingesting calories that the human body does not need. For example, those with high calories include sweet cereal, chocolate, milk shake, amazake, sweet soft drinks, carbonated drinks,
Examples of high-calorie foods such as beer, sake, shochu and other alcoholic beverages or dishes cooked using vegetable oils such as potato chips, tempura, and french fries. High-calorie food). This high-calorie food is enteric-coated fine powder of tea leaves or enteric-coated green tea leaves (hereinafter abbreviated as tea leaf fine powder or green tea leaves). Is mixed, mixed and adhering to the inside of high-calorie foods, and the fine powder of tea leaves is eaten together with the high-calorie foods, so that the human body breaks down the high-calorie foods into sugar. The fine powder of leaves is also decomposed into the human body at the same time to produce catechin and complex polysaccharide (hereinafter abbreviated as catechin), so the sugar and catechin at the stage when the human body decomposed high-calorie foods At the same time, it is bound inside the body and excreted outside the body. Since this sugar and catechin are decomposed and produced in the human organs at the same time, the blood glucose level of the human body will be reduced as a result, so that the therapeutic means for the prevention and treatment of diabetes To do.

In addition, as described above, there are high blood pressure and gout as diseases caused by excessive intake of high-calorie foods that are not needed by the human body. The tea leaf powder is mixed inside the high-calorie food as described.
It is a therapeutic means aimed at preventing and treating hypertension and gout by eating and adhering fine powder of tea leaves together with high-calorie foods.

Furthermore, it is infected with influenza virus, hepatitis virus, AIDS virus (hereinafter abbreviated as hepatitis or hepatitis virus) present in the blood, for example, the human body is infected with hepatitis When a patient with hepatitis drinks alcoholic water, hepatitis virus present in the human body is activated, and the division speed at which hepatitis virus divides and reproduces increases. Beer, sake, shochu, etc. are high-calorie foods mixed, mixed, and adhering to enteric-coated tea leaf fine powder as a means to prevent this hepatitis virus from being activated by alcoholic drinking water Alcohol drinking water has the effect of inhibiting the activation of hepatitis virus. As a result, even if the human body is infected with hepatitis virus, alcoholic beverages such as beer that contain fine powder of tea leaves will mix fine powder of tea leaves even for hepatitis patients. Alcohol drinking water that can be used can be used as a therapeutic means for preventing and treating hepatitis.

In addition, the mechanism that is the mechanism by which cancer cells develop in the human body is very simple. Humans do not produce antioxidants such as peroxidase, vitamin E, carotenoids, and vitamin C that are necessary to protect human bodies from lipid peroxides produced by ultraviolet rays. This is why cancer cells develop. As a means to prevent these cancer cells from developing in the human body, green tea leaves, which are tea leaves, are removed from lipid peroxides produced by ultraviolet rays, cancer cells, various bacteria, or various viruses. You should refer to what you are protecting. Well, the characteristic of green tea that makes up the fine powder of tea leaves is that peroxidase, vitamin E, carotenoids, vitamin C in the body to protect their leaves, which are green tea leaves from lipid peroxides born by ultraviolet rays Etc. to protect themselves. Green tea contains a large amount of antioxidants such as catechin, beta-carotene, vitamin E, and vitamin C, which are antioxidants. However, since antioxidants are contained in the tea leaves themselves, which are green tea, and the tea liquid contains only a very small amount, the anti-oxidant substance is effective only for eating the green tea leaves that are the green tea leaves. It is not possible to consume large amounts of oxidants. Furthermore, in the case of catechins that contain green tea, catechins easily undergo a condensation reaction that binds to proteins, lipids, and sugar chains, so catechins that contain green tea are present in the stomach of the human body. It easily binds to proteins, lipids, and sugar chains. The catechin compound in which this catechin is bound to protein, lipid, and sugar chain passes through the intestinal tract and is excreted from the large intestine, so catechin is absorbed into the human blood by the intestinal tract, the digestive organ of the human body The ratio of being used is extremely small. Therefore, the fine powder of tea leaves with a particle diameter of 50 μm or less, which is the fine powder of tea leaves, which is the object of the present invention, is passed through the stomach of the human body and passed through the stomach of the human body in the intestinal tract, the digestive organ. For the purpose of absorbing fine powder, tea leaf fine powder was made enteric solvent using enteric coating material such as HPMCP, Twein, or shellac. It contains a large amount of antioxidants that prevent cancer cells from developing in the body. As a result, if the human body ingests fine powder of tea leaves that have undergone enteric coating, the human body will prevent the development of cancer cells, so treatment aimed at preventing and treating cancer cells Means.

Further, the physical properties of tea leaf fine powder or green tea leaf (hereinafter referred to as tea leaf fine powder) are changed to the physical properties as shown in (1), (2) and (3) below. For the purpose of changing, tea using HPMCP, or twein or shellac (hereinafter abbreviated as twein), which is a coating material for enteric solvent, and an ethanol aqueous solution having an ethanol content of 60% to 80% as a solvent. When the physical properties of the fine powder of the leaves are changed, (1), the physical properties of the fine powder of tea leaves are very hard solids from the syrup state that is in the varicella state depending on the mixing ratio of zein and ethanol aqueous solution. Depending on the mixing ratio of the tea leaf fine powder, twein, and ethanol aqueous solution, the tea leaf fine powder with different physical properties can be used as raw materials. Leaves fine powder as raw material Substance of the physical properties can be used to produce. As for (2), the physical properties of the mixture of tea leaf fine powder, zein, and ethanol aqueous solution do not dissolve at all in the strongly acidic gastric juice that is the digestive tract. Inside the sex gastric juice, it becomes a substance that further condenses and changes into a solid substance that is hard and solid. As for (3), the physical properties of the mixture of tea leaf fine powder, zein, and ethanol aqueous solution are the properties of the intestinal solvent that dissolves easily inside the strong alkaline intestinal tract, which is the digestive organ. It becomes the physical property of the nature of the fine powder of tea leaves.

In addition, tea leaf fine powder or green tea leaf (hereinafter abbreviated as tea leaf fine powder), HPMCP, zein, or shellac (hereinafter abbreviated as coating material for enteric solvent) Examples of the case where enteric coating processing is performed using Twein or Kobayashi Twein) will be described below. For example, a tea leaf fine powder having a particle size of 50 μm or less, or a particle size of 50 μm or more, for example, Kobayashi Perfume Co., Ltd. White powder Lot No.TD3W0 derived from corn protein
02 (hereinafter referred to as Twein or Kobayashi Twein for short) from 60% ethanol content
Disperse Kobayashi Twein in 80% ethanol aqueous solution and dissolve the Kobayashi Tsein dissolved in ethanol aqueous solution and the mixing ratio of tea leaf fine powder, for example, the weight of tea leaf fine powder is 3kg , Kobayashi Tsein is 5% of 3kg of tea leaf fine powder
The ratio of 150g Kobayashi Twein is 60% to 80% ethanol aqueous solution.
Mix the ethanol aqueous solution dissolved in 3 liters with the tea leaf fine powder weighing about 3kg, and mix the ethanol aqueous solution with tea leaf fine powder and Kobayashi Tsein dissolved. Then, the fine powder of tea leaves after being kneaded into a clay state and dried for about 5 days in a room temperature room temperature of 45 ° C or lower or 85 ° C or lower, for example, After reducing the amount of water to 0.6% or less, by using a grinder and a jet mill to make enteric coated fine powder of tea leaves again, the digestive organs dissolve in the highly acidic gastric juice. Without making it, it is possible to make it the nature of fine powder of tea leaves that dissolve in the digestive juice inside the strongly alkaline intestinal tract.

Furthermore, when mixing the three components of tea leaf fine powder, Kobayashi Twein and ethanol aqueous solution described above and kneading them into a clay state, the following means (1) and (2) are used. Then, the tea leaf fine powder, Kobayashi Twein, and ethanol aqueous solution may be mixed and kneaded into a clay state and then dried. As (1), for example, 3 kg of powdered tea leaf fine powder and 150 g of powdered Kobayashi Twein were mixed in both the powdered tea leaf powder and Kobayashi Twein at the powdered stage. In the interior of the later mixture, the ethanol content starts from 60%
About 3 liters of 80% ethanol aqueous solution is mixed and kneaded into a clay, then dried to make the water content 0.6% or less. As (2), for example, 3 kg of fine powder of tea leaves in powder form and about 3 liters of an ethanol aqueous solution with an ethanol content of 60% to 80% are mixed and kneaded into a clay state. After mixing 150g of Kobayashi Twein inside the mixture after mixing, it is kneaded again into a clay state and dried to a moisture content of 0.6% or less, making the nature of the tea leaf fine powder enteric solvent The purpose is to process. At the same time, it is possible to form an enteric coated tea leaf fine powder having the same effect as the tea leaf fine powder.

In addition, as an example explained above, for example, a mixture of tea leaves fine powder, Kobayashi Twein and ethanol aqueous solution mixed into a clay state and mixed into a dosage form Are tablets, granules, scattered, syrups. Alternatively, HPMCP or zein or shellac enteric coating processed enteric solvent is again formed on or inside the surface.

Furthermore, as described above, polyphenone 70S, which is a catechin in the fine powder state that Mitsui Norin Co., Ltd. manufactures and sells, is a catechin in the fine powder state that is manufactured and sold by Taiyo Kagaku Co., Ltd. Sanfenon BG-3, or other purified fine powdered catechin (hereinafter abbreviated as catechin, or polyphenone 70S, or Sanphenon BG-3), explained above, fine powder of tea leaves In the same way that the physical properties of the catechin are changed, the physical properties of the fine powder of catechin can be changed to the physical properties such as the following (1), (2), and (3) with an enteric solvent coating material. When the physical properties of a fine powder of catechin are changed using a certain HPMCP, or Twein or Shellac (hereinafter referred to as Twein) and an ethanol aqueous solution having an ethanol content of 60% to 80% as a solvent, 1 As for the physical properties of catechin fine powder, depending on the mixing ratio of twein and ethanol aqueous solution, catechin fine powder, twein and ethanol aqueous solution, ranging from syrup state of elutriation to solid physical property of extremely hard solid Depending on the mixing ratio, the catechin fine powder having various physical properties can be used as a raw material, and a physical substance can be produced using the catechin fine powder as a raw material. As for (2), the physical properties of the mixture of catechin fine powder, zein, and ethanol aqueous solution do not dissolve at all in the strongly acidic gastric juice that is the digestive organ, Inside the gastric juice, it becomes a substance with the property of further condensing and changing into a solid substance that is hard and solid. (3) As a catechin, the physical properties of a mixture of catechin fine powder, zein, and ethanol aqueous solution are intestinal solvent properties that dissolve easily in the strong alkaline intestinal tract, which is the digestive organ. It becomes the physical property of the nature of the fine powder.

In addition, as described above, an embodiment in which enteric coating processing is performed using HPMCP, which is an enteric solvent coating material, or zein, or shellac (hereinafter abbreviated as zein), which is described above. This is explained below. For example, 150g of Kobayashi Twein with a catechin fine powder weight of 3kg and a weight of 3kg of Kobayashi Twein from 60% to 80%.
An aqueous ethanol solution containing about 0.3 liters of an ethanol aqueous solution in which about 0.3 liters of ethanol solution and about 3 kg of catechin fine powder are mixed to dissolve the catechin fine powder and Kobayashi Twein After mixing and kneading into a clay state, the catechin is dried for about 5 days in a room temperature room temperature of 45 degrees C or less, or 85 degrees C or less,
For example, after setting the water content to 0.6% or less, use a pulverizer and a jet mill to characterize the fine powder of catechin with a particle diameter of 50 μm or less, or 50 μm or more, and enteric coating using Kobayashi Twein By making processed fine powder of catechin, it does not dissolve inside the strongly acidic gastric juice that is the digestive organ, but is dissolved inside the digestive juice inside the strong alkaline intestinal tract and absorbed into the body The properties of the catechin fine powder (hereinafter referred to as “catechin coated with catechin” or “catechin coated with zein”). As a result, conventional catechins easily undergo a condensation reaction with proteins, sugar chains, lipids, etc. that are present in strongly acidic gastric juice, and are chemically absorbed and not absorbed by the intestine. It is discharged outside the body. However, since catechin coated with zein is absorbed into the body in the intestine, adult diseases such as infection, diabetes, hypertension, anticancer, and hay fever as described above. There is an effect which becomes a therapeutic means for the purpose of treatment.

Furthermore, as described above, polyphenone 70S, which is a catechin in the fine powder state that Mitsui Norin Co., Ltd. manufactures and sells, is a catechin in the fine powder state that is manufactured and sold by Taiyo Kagaku Co., Ltd. Sanphenon BG-3 or other purified fine powdered catechins or HPMCP
Or a catechin (hereinafter abbreviated as catechin or a catechin coated with zein) coated with a twein or shellac (hereinafter abbreviated as twein) as a tablet Enteric coating using enteric coating materials such as HPMCP, or Twein, or shellac (hereinafter abbreviated as HPMCP), on granules, capsules, powders, syrups, or their surfaces again The processed dosage form is a tablet, granule, capsule, powder, syrup (hereinafter abbreviated as catechin, powder, catechin tablet or enteric solvent coated with catechin or zein) Prevent infectious diseases such as influenza, acute gastroenteritis, malaria, AIDS, sleeping sickness, adult diseases such as diabetes, hypertension, anticancer, hay fever by using intestinal solvent in dosage form, And a therapeutic means intended to be treated, and a raw material for the medicinal product.

In addition, as described above, Mitsui Norin Co., Ltd. manufactures and sells polyphenone 70S, Taiyo Kagaku Co., Ltd., which is a fine powdered catechin purified by extracting with hot water from tea leaves. Extraction of hot water from Sanphenon BG-3, a catechin in the form of fine powder that has been purified by hot water extraction from tea leaves, which is manufactured and sold, or other tea leaves (hereinafter abbreviated as green tea) The catechin in the form of a fine powder that has been refined by the preparation is a tablet, granule, capsule, powder, syrup, or hybromellose phthalate (hereinafter abbreviated as HPMCP) on the surface or inside thereof. As described above, or enteric coating using enteric coating material such as twein or shellac (hereinafter abbreviated as HPMCP) to make enteric solvent. Infectious There are advantageous effects that the treatment means aimed diabetes, hypertension, anti-cancer, treatment of such adult diseases, such as hay fever.

Furthermore, as explained above, Mitsui Norin Co., Ltd. manufactures and sells polyphenone 70S, Taiyo Kagaku Co., Ltd., which is a fine powdered catechin purified by extracting with hot water from tea leaves
Manufactured and sold by Sanfenon BG-3, a fine powdered catechin purified by hot water extraction from tea leaves, or other tea leaves (hereinafter abbreviated as green tea) A catechin in a fine powder state (hereinafter, abbreviated as polyphenone 70S, or sanphenone BG-3, or catechin), which has been extracted and purified, is pilled into tablets or granules, and catechin tablets Or catechin granules (hereinafter abbreviated as tablets, granules, or catechin tablets)
Table 18 shows the formulation table for forming.

Further, as examples other than those described above, for example, catechin or fine powder of tea leaves (hereinafter abbreviated as catechin or fine powder of tea leaves) is used, Is intended for oral administration to infants, children and adults as a means of treating infants infected with malaria, influenza, acute gastroenteritis that develops due to viruses such as rotavirus and norovirus, or other infections When the dosage form to be taken forms tablets, granules, capsules, powders, and syrups, catechin or fine powder of tea leaves, twein, and ethanol solution are mixed to form a clay. The mixture after kneading and mixing is made into tablets, granules, capsules, powders, and syrups. Or HPMCP, or twein, or shellac (hereinafter abbreviated as twein) on or inside the surface.
Enteric coating is processed to form enteric solvent.

In addition, when forming a syrup, catechin or fine powder of tea leaves and fine powder of twein are mixed with an ethanol aqueous solution containing ethanol with an ethanol content of 60% to 80%. Then, catechin or fine powder of tea leaves, zein and ethanol aqueous solution are dissolved and mixed, and then diluted with an aqueous glucose solution to form a syrup agent.

Further, a syrup may be formed by mixing catechin or fine powder of tea leaves, zein and an aqueous ethanol solution by means as shown in the following (1) or (2).

(1) As for the inside of the mixing part after mixing an aqueous ethanol solution into the mixture after mixing the catechin or fine powder of tea leaves and twein into a clay state, A syrup is formed by diluting with an aqueous glucose solution.

(2) As for the inside of the mixture after mixing the catechin or the fine powder of tea leaves and the aqueous ethanol solution into the clay after mixing with zein, A syrup is formed by diluting with an aqueous glucose solution. However, it is necessary to remove the ethanol so that the ethanol content is 0.1% or less by evaporating the ethanol used for dissolving twein by means such as heating by the processing means described above.

In conclusion, as explained above, enteric coated fine powder of tea leaves, enteric coated green tea leaves, or tea leaves (hereinafter abbreviated as green tea) Catechin in a fine powder state purified by hot water extraction from HPMCP or Twein,
Alternatively, an enteric coating material such as shellac (hereinafter abbreviated as twein) is applied on the surface of catechin, or catechin having zein absorbed in catechin, or tea leaf ( (Hereinafter abbreviated as "green tea"). Hot powder extracted from purified catechin in the form of fine powder. HPMCP or zein on the surface of tablet, granule, capsule, powder, syrup or inside. Or enter the surface of tablets, granules, capsules, powders, syrups using enteric coating materials such as shellac (hereinafter abbreviated as twein), or absorb zein inside HPMCP or Twein is a fine powdered catechin purified by hot water extraction from intestinal solvent or tea leaves (hereinafter abbreviated as green tea) made mainly from catechins made Or shellac (hereinafter abbreviated as twein)
Tablets, granules, capsules after the dosage form is processed into tablets, granules, capsules, powders, syrups of catechins in a fine powder state that have been enteric coated using enteric coating materials such as , HPMCP or Twein, again on or inside the powder, syrup,
Or enteric coating processed using enteric coating materials such as shellac, such as cereals, chocolate, potato chips, rice crackers, bread etc. Various miscellaneous candy such as confectionery, or confectionery such as buns, cakes, or bread, or confectionery bread, or bread for hamburgers, or bread for sandwiches, or octopus, or okonomiyaki, Or hot cake powder, Korean food chijimi powder, dango powder, or onigiri,
Or lunch box rice, rice cake, rice cake in rice cake, rice cake in rice cake, rice cake bread, Chinese rice cake, rice cake rice cake, rice cake in the middle, rice cake, or rice Rice cooked together, white rice mixed with white rice, or white rice mixed with non-washed rice, or udon, or somen, or champon noodles, spaghetti, macaroni, buckwheat, ramen, instant ramen, or grilled Buckwheat, or instant baked buckwheat, or milk shake, or ice cream, or ice candy, or pudding, or yogurt, or milk, or mutton, or caramel, or gummy candy, or chewing candy, or drops, or other foods, Or drinking water, juice, milkshake, amazake, or a Cole drinking water (hereinafter abbreviated as candy, or confectionery, or bun, or cake, or bread, or other foods, or drinking water, or juice, or soft drink, or amazake, or various miscellaneous alcoholic beverages. In the inside of beer, sake, shochu, whiskey, wine, liqueur and other alcoholic beverages that are water), tea leaf fine powder, green tea leaf, or enteric-coated fine powder of catechin Functional candy for the purpose of preventing and treating infectious diseases such as influenza, acute gastroenteritis, malaria, AIDS, sleeping sickness, or adult diseases such as diabetes, hypertension, anticancer, hay fever, Or an additive for forming drinking water, or soft drink, or juice, milk shake, amazake, or alcoholic drink. It is also a health supplement. In addition, enteric-coated catechin fine powder mixed, mixed, adhering candy, drinking water, soft drink, juice, amazake, sake, shochu, or other alcoholic drinks By drinking or eating sweet cereals, chocolates and other candy, now called national illness, due to diabetes, high blood pressure, or anti-cancer, or infections such as influenza, hepatitis, AIDS, or gout It is a therapeutic means for the purpose of treating uric acid by lowering the uric acid level by excreting certain uric acid outside the body. Or it is set as the treatment means aiming at treating other lifestyle-related diseases.

Furthermore, as described above, enteric-coated fine powder of catechin (hereinafter,
Catechin, enteric-processed catechin, or catechin as enteric solvent) and chloroquine, which is a special drug for malaria, and catechin as enteric solvent, or artesunate and catechin as enteric solvent, respectively. Compared with oral administration of catechin and chloroquine without enteric coating, or catechin and artesunate without enteric coating, It has been found that catechin and chloroquine as solvents, or catechin and artesunate as intestinal solvents can be used in combination to further increase the sensitivity to resistant malaria parasites.

In addition, the characteristics of green tea, which constitutes the fine powder of tea leaves, is that peroxidase, vitamin E,
It protects itself by producing carotenoids and vitamin C. Green tea contains a large amount of antioxidants such as catechin, beta carotene, vitamin E and vitamin C which are antioxidants. However, since antioxidants are contained in the tea leaves themselves, which are green tea, and the tea liquid contains only a very small amount, the anti-oxidant substance is effective only for eating the green tea leaves that are the green tea leaves. It is not possible to ingest large amounts of oxidizing substances. From the explanation above, when explaining the manufacturing process of catechin again, the catechin that has been manufactured and sold in the past is bancha, which is a tea leaf,
Manufactures and sells catechins as fine powders obtained by drying the hot water extracted from sencha and green tea (hereinafter abbreviated as green tea) using a drying means such as spray drying.
As explained above, the liquid extracted from green tea with hot water contains only a small amount of antioxidants or complex polysaccharides (hereinafter abbreviated as antioxidants or complex polysaccharides). The catechins that have been manufactured and sold as catechins in the past, using the liquid extracted from green tea as the raw material, as described above, contain only a very small amount of antioxidants or complex polysaccharides. There is a drawback that it is not included. Therefore, as a means to solve this drawback, green tea, which is a tea leaf, is used for the purpose of incorporating green tea leaf, which is a tea shell of green tea, into the blood of the human body (
In the following, for the purpose of absorption in the intestinal tract, which is a digestive organ, the tea leaves are reduced to 50 μm or less, or 50 μm or more. For the purpose of absorbing fine powder, the intestinal tract of the human body can be obtained by using enteric coating materials such as HPMCP, twein, or shellac for tea leaf fine powder and using enteric solvent for tea leaf fine powder. Catechin, an antioxidant contained in tea leaf fine powder in the process of degrading tea leaf fine powder taken directly into human blood from the liver and kidneys , Beta-carotene, vitamin E, vitamin C and other antioxidants, or complex polysaccharides such as L-arabinose, D-ribose, and D-glucose, or other polysaccharides or other effects D-Mannose with And liver L- sorbose substances of human body organs have effects of the hypoglycemic such, and an object thereof to the production by the kidney.

Furthermore, the complex polysaccharide having the effect of lowering blood glucose that lowers blood glucose level in blood is a generic term for substances having a molecular weight of 40,000 and L-arabinose, D-ribose, and D-glucose as constituent sugars. To obtain a complex polysaccharide. In addition to complex polysaccharides, there is a blood glucose lowering effect, D
-Hypoglycemic substances that have the effect of lowering blood glucose levels in blood, including mannose and L-sorbose, are collectively referred to as complex polysaccharides.

In addition, as described above, bancha, sencha, and green tea containing complex polysaccharides that are effective in lowering blood sugar in blood, anticancer effects, and infectious diseases such as malaria and influenza (
Hereinafter, L-arabinose, D-ribose, D-glucose having a molecular weight of about 40,000, or D-mannose, L-sorbose (hereinafter abbreviated), which has an effect of lowering blood glucose, is abbreviated as green tea. Complex polysaccharides, which are hypoglycemic substances that have the effect of lowering blood glucose levels in the blood, such as complex polysaccharides, and are extracted from green tea and purified to a purity of over 99% The method of producing is described in (1), (2), (3), and (4) below.

(1) As for the temperature of the green tea leaves, the temperature of the aqueous solution is within 45 degrees C, within 50 degrees C, or 60 degrees C
The green tea leaves are soaked in the aqueous solution by immersing in the aqueous solution within 3 hours or more for about 3 hours or more.

(2) As an ethanol aqueous solution having an ethanol content of 96% or more in an aqueous solution in which green tea leaves are soaked by immersing green tea leaves for 3 hours or 3 hours or more and sufficiently containing water, or When anhydrous alcohol is mixed and mixed, a jelly-like substance is deposited in the aqueous solution from the green tea leaves immersed in the aqueous solution. Alternatively, a jelly-like substance, which is a complex polysaccharide, may be precipitated from green tea leaves by the following processing means. For example, green tea leaves that have been dipped in green tea leaves for 3 hours or 3 hours or more and soaked in water, pulled out from the aqueous solution, drained from the green tea leaves, and then dehydrated However, when the green tea leaves containing water were added, the ethanol content from the green tea leaves was reduced. A jelly-like substance from green tea leaves in a solution of 96% or more ethanol aqueous solution or an anhydrous alcohol solution has an ethanol content of 96% or more, or a jelly-like substance from green tea leaves in an anhydrous alcohol solution. Precipitate and come out.

As (3), when green tea leaves are soaked for 3 hours or 3 hours or more and dehydrated, and then mixed with ethanol aqueous solution or anhydrous alcohol, a jelly-like substance precipitates from the green tea leaves. Within 45 degrees C after filtering the jelly-like substance deposited from the green tea leaves with suction,
Alternatively, when it is dried at a temperature within 50 ° C. or 60 ° C., a complex polysaccharide in a powder state can be formed.

As for (4), when extracting and purifying complex polysaccharides from green tea leaves,
When heated at a temperature of more than C, 50C or more, or 60C or more, the structure of the polymer with a molecular weight of around 40,000 will be destroyed, resulting in anticancer effects, hypoglycemic action, Since the effects such as the virus effect and antimalarial effect decrease, the complex polysaccharide is extracted from green tea leaves and purified, and purified to form a powdered complex polysaccharide that is highly purified and dried. For the purpose of purifying the complex polysaccharide by extracting and drying the complex polysaccharide from green tea leaves at a temperature of 45 degrees C or less, 50 degrees C or less, or 60 degrees C or less There is.

Furthermore, the complex polysaccharide fine powder (hereinafter referred to as “powdered state”) having a purity of 99% or more by drying the liquid of high-purity complex polysaccharide extracted from green tea leaves and purified as described above. (For short, complex polysaccharides) are tasteless and odorless with no color, no scent, no odor, and are therefore raw materials for pharmaceuticals for the purpose of forming pharmaceuticals such as hypoglycemic agents or anticancer agents. In addition, the complex polysaccharide liquid extracted from green tea leaves and purified to a high purity of 99% or more is dried to give a powdered powder of complex polysaccharides with tasteless and odorless cereals, chocolate, potato chips, Various candy such as gum, jasper, chocolate, biscuits, rice crackers, etc., or cakes such as rice crackers, breads, etc., cakes, breads, confectionery breads, candy breads, or hamburgers Bread to be used for bread, or bread to be used for sandwiches, octopus grilled powder, okonomiyaki powder, hot cake powder, Korean food chijimi powder, dumpling powder, or onigiri, lunch box rice, or餅, 餡 to be put in 餅, 餡 to be put in bun, or bun of bread, Chinese bun, or moon cake, 餅 or cas Rice cooked with la or rice, or white rice mixed with white rice, or white rice mixed with non-washed rice, or udon, or somen, or champon noodles, spaghetti, macaroni, buckwheat, ramen, or Instant noodles, or baked buckwheat, or instant baked buckwheat, or milk shake, or ice cream, or ice candy, or pudding, or yogurt, or milk, or yokan, or caramel, gummy candy, or chewing candy, or drops, or Other food or drinking water,
Or juice, milkshake, amazake, or alcoholic drinking water (hereinafter abbreviated candy, or confectionery, or bun, or cake, or bread, or other food, or drinking water,
Or juice, soft drinks, amazake, or miscellaneous alcoholic drinks such as beer, sake, shochu, whiskey, wine, liqueur, etc.) Or adhering to rice crackers, etc., or mixing in chocolate or bread etc. and mixing as described above, influenza, acute gastroenteritis,
Functional candy, drinking water, or soft drinks intended to prevent and treat infectious diseases such as malaria, AIDS, sleeping sickness, or adult diseases such as diabetes, hypertension, anticancer, hay fever It is an additive for forming water, juice, milkshake, amazake, or alcoholic water. It is also a health supplement.

In addition, a supplementary explanation will be given of the results of an experiment in which mice were infected with resistant malaria parasites, as requested by Associate Professor Akira Ishii, Hamamatsu Medical University, shown in Tables 15 and 16 above. Table 15 and Table
Before explaining the experimental results shown in Fig. 16, the steps until the human body acquires immunity will be explained.
The order in which the human body memorizes immunity and the immune memory is established and the human body acquires immunity acquires the immunity in the following order (1) to (4).

(1) includes antigens that have invaded the human body, such as malaria parasites, trypanosoma protozoa, influenza viruses, viruses, bacteria, syphilis, parasites, pollen, proteins, peptides formed of 5 or more amino acids, etc. It begins with the phagocytosis of macrophages and other phagocytic cells.

As (2), the phagocytic cell presents a part of the antigen to the helper T cell.

As (3), the helper T cell further transmits information to the B cell to cause the B cell to differentiate into a plasma cell having an antibody production ability capable of producing an antibody.

As for (4), plasma cells produce antibodies to form antigen-antibody complexes. In general, it takes about one week from the initial infection until the above immune response is established.

In addition, when the same antibody described above is first infected in the human body and the antigen has invaded the human body for the second time, the immune memory is established. Plasma cells produce antibodies and form antigen-antibody complexes.

Furthermore, the plasma cells that have memorized immunity described above may forget their immune memory over time. This is the tolerance of immune memory.

Further, as described above, when an antigen such as a malaria parasite or influenza virus that has entered the human body enters the human body, the human body acquires immune memory in approximately seven days. The human body acquires immune memory and plasma cells produce antibodies, forming an antigen-antibody complex, and the human body uses antigens such as malaria parasites or influenza viruses that have invaded the human body. Destroying or killing.

In conclusion (1), as explained above, in the case of an initial infection in which an antigen such as a malaria parasite or influenza virus has entered the human body as an antigen in the human body, it takes approximately 7 days. The human body acquires immune memory. This means that, for example, in the case of the first infection in which an antigen such as a malaria parasite or influenza virus has entered the human body,
The malaria parasite that has invaded the human body for approximately one week until the human body acquires immune memory, or the malaria parasite if the growth of antigens such as influenza virus is suppressed or killed by drugs, etc., or Since the autoimmunity of the human body reduces the growth of influenza viruses and other malaria parasites, or the growth of influenza viruses and the like, the progression of the disease state stops.

As a conclusion (2), the human body acquires immune memory in about 7 days as explained above. Here, we asked Associate Professor Akira Ishii of Hamamatsu Medical University shown in Tables 15 and 16, and the experimental results of infecting mice with malaria parasites, as shown in Figs. 4 and 5, Kyushu This is a mouse that asked Professor Masahiko Kurokawa of the University of Health and Welfare. Plasmodium b
Table 15 shows the experimental results regarding the combined effects of catechins and antimalarial drugs, chloroquine and artesunate in erghei NK65-infected mice. The combined effect of catechins was evaluated by suppression of protozoan growth in the combined group with respect to the ART single administration group on day 7 after infection. 2 of catechins
Intraperitoneal administration at a daily rate of 5 mg / kg body weight showed no side effects. The combination group showed significant protozoan growth inhibition. Moreover, the experimental results shown in Table 16 indicate the survival days of mice. Table 16 shows catechins, sanphenone BG-3 (BG-3) and polyphenone
The single effect of 70S (70S) on CQ-resistant murine malaria parasite infection or chloroquine (
CQ) or combined use with artesunate (ART) was examined.

Further, in the experimental results shown in Table 16, it is possible to judge from the survival days of mice that mice other than those in which one mouse shown in group 3 and group 4 died on the seventh day are mice. Since he survived for 15 to 52 days, it can be judged that he has acquired immune memory.

In addition, the experimental results shown in Table 15 and Table 16 suggest the possibility of clinical application of CQ, ART and catechins, but as a mechanism contributing to the enhancement of the antimalarial effect of CQ and ART, The malaria parasite grows inside the red blood cells. Heme iron (Fe) and catechin, which are the main constituents of this red blood cell, undergo a condensation reaction or chemical bond, thereby suppressing or inhibiting the growth of malaria parasites inside the red blood cell. It can be judged that it is.
However, the results of this experiment suggest that the combination of CQ, ART, and catechins suggests the potential for clinical application of catechins. To clarify the mechanism that contributes to the enhancement of antimalarial effects of CQ and ART. Further research is needed.

As a conclusion (3), a period of about 7 days from the invasion of an antigen such as a malaria parasite or influenza virus into a living human body until the human body acquires immune memory,
By using drugs for the purpose of survival of the human body, by suppressing or killing the growth of antigens such as malaria parasites or influenza viruses that have invaded the human body, the human body is further affected by the immune memory acquired by the human body. You will be able to survive. In short, antibodies are produced in a period of about 7 days after the antigen enters the human body. If the human body is allowed to survive for a period of about 7 days, the human body can survive by autoimmunity.

As a conclusion (4), the period of time required from when the antigen invades into the human body until the human body acquires immune memory is approximately 7 days. However, it takes about 7 days for the human body to acquire immune memory, but considering safety, if there is a date and time twice as long as about 7 days, that is, about 14 days, It may be considered that the human body acquires 100% immune memory after an antigen such as malaria parasite or influenza virus enters the body. From this, the survival days of the mice shown in Table 16 described above, combined use of chloroquine and sunphenone BG-3 shown in group 3, or chloroquine and polyphenone 70S shown in group 4 In combination with chloroquine-resistant murine malaria parasites, except that one mouse died in 7 days, other mice survived for 15 to 52 days Therefore, it can be determined that the mouse has acquired immune memory, so the action effect of the combined use of chloroquine and catechins is a great discovery.

Furthermore, the tea leaf fine powder obtained by pulverizing tea leaves using a jet mill in the measurement diagram shown in FIG. 12 was enteric-coated using zein, an enteric coating material. The measurement method of tea leaf fine powder, which was used for the tea leaf fine powder, which was enteric coated using the enteric coating material Twein, was used again. This is described as (A).

The description as (A), tea leaf fine powder, or green tea leaf (hereinafter abbreviated as tea leaf fine powder) HPMCP, or twein, or shellac, which is a coating material for enteric solvent Hereinafter, an example in which enteric coating processing is performed using abbreviated zein or Kobayashi zein) will be described below. For example, a tea leaf fine powder having a particle size of 50 μm or less, or a particle size of 50 μm or more, for example, Kobayashi Perfume Co., Ltd. White powdered corn protein powder
Lot No. TD3W002 (hereinafter referred to as Twein or Kobayashi Twein for short) was dispersed in an aqueous ethanol solution with an ethanol content of 60% to 80%, and Kobayashi Twein was dissolved in the aqueous ethanol solution. The mixing ratio of aqueous ethanol solution and tea leaf fine powder, for example, if the weight of tea leaf fine powder is 3 kg, Kobayashi Tsein is 5% of the weight of 3 kg of tea leaf fine powder. Mix 150g of Kobayashi Twein with an ethanol aqueous solution with an ethanol content of 60% to 80% dissolved in 3 liters and a tea leaf weight of about 3kg. Mixing an aqueous solution of tea leaves with an aqueous solution of tea leaves and Kobayashi Twein, kneading them into a clay state, and mixing the fine powder of tea leaves, the room temperature is 45 degrees C or less, or 85 degrees In a room temperature room below C For example, after drying for about 5 days and reducing the water content to 0.6% or less, it is digested again by using a grinder and a jet mill to make enteric coating fine powder. It does not dissolve inside the strongly acidic gastric juice that is an organ, but can be made into the nature of fine powder of tea leaves that dissolves inside the digestive juice inside the strongly alkaline intestine.

In addition, the method for producing a complex polysaccharide described above will be described again as (B) below.

(B), bancha, sencha, green tea (hereinafter referred to as bancha) containing complex polysaccharides that are effective in the action of hypoglycemia in blood, anticancer action, and infectious diseases such as malaria and influenza
L-arabinose, D-ribose, D-glucose having a molecular weight of about 40,000, or D-mannose having a hypoglycemic effect, from green tea or tea leaf fine powder for short)
L-sorbose (hereinafter abbreviated as complex polysaccharide) is purified by extracting and purifying complex polysaccharides that are hypoglycemic substances that have the effect of lowering blood glucose levels in blood from green tea. 99
The method for producing complex polysaccharides as high as% or more is described in the following (1), (2), (3), and (4)
I will explain in.
(1) As for the temperature of the green tea leaves, the temperature of the aqueous solution is within 45 degrees C, within 50 degrees C, or 60 degrees C
The green tea leaves are soaked in the aqueous solution by immersing in the aqueous solution within 3 hours or more for about 3 hours or more.
(2) As an ethanol aqueous solution having an ethanol content of 96% or more in an aqueous solution in which green tea leaves are soaked by immersing green tea leaves for 3 hours or 3 hours or more and sufficiently containing water, or When anhydrous alcohol is mixed and mixed, a jelly-like substance is deposited in the aqueous solution from the green tea leaves immersed in the aqueous solution. Alternatively, a jelly-like substance, which is a complex polysaccharide, may be precipitated from green tea leaves by the following processing means. For example, green tea leaves that have been dipped in green tea leaves for 3 hours or 3 hours or more and soaked in water, pulled out from the aqueous solution, drained from the green tea leaves, and then dehydrated When an ethanol aqueous solution with an ethanol content of 96% or more or a green tea leaf containing water is put into the absolute alcohol solution, an ethanol aqueous solution with an ethanol content of 96% or more is introduced from the green tea leaf. Alternatively, the jelly-like substance from the green tea leaf in the solution of the anhydrous alcohol solution has an ethanol content of 96% or more, or the jelly-like substance precipitates from the leaf of the green tea in the anhydrous alcohol solution.
(3) As a jelly-like substance deposited from green tea leaves in an aqueous solution mixed with ethanol or anhydrous alcohol in an aqueous solution in which green tea leaves are soaked for 3 hours or more and 3 hours or more Powdered complex polysaccharides can be formed by drying at a temperature within 45 ° C, 50 ° C or 60 ° C after suction filtration.
As for (4), when extracting and purifying complex polysaccharides from green tea leaves,
When heated at a temperature of more than C, 50C or more, or 60C or more, the structure of the polymer with a molecular weight of around 40,000 will be destroyed, resulting in anticancer effects, hypoglycemic action, Since the effects such as the virus effect and antimalarial effect decrease, the complex polysaccharide is extracted from green tea leaves and purified, and purified to form a powdered complex polysaccharide that is highly purified and dried. For the purpose of purifying the complex polysaccharide by extracting and drying the complex polysaccharide from green tea leaves at a temperature of 45 degrees C or less, 50 degrees C or less, or 60 degrees C or less There is.

Furthermore, the contents explained as (A) described above, and the contents explained as (B), the tea leaf fine powder zein and the ethanol aqueous solution are mixed. This is a processing method for enteric coating of tea leaf fine powder using enteric coating materials such as twein. As described in (A), the tea leaf fine powder is enteric coated. The contents of the method and the method for producing the complex polysaccharide described as (B) will be described again below. L-arabinose, D-ribose, D- having a molecular weight of about 40,000 from bancha, sencha and green tea (hereinafter abbreviated as green tea or tea leaf fine powder) containing complex polysaccharides G-glucose or D-mannose having an effect of lowering blood sugar, L-
Extract complex polysaccharides, which are hypoglycemic substances that lower blood glucose levels in blood, such as sorbose (hereinafter abbreviated as complex polysaccharides), from green tea or fine powder of tea leaves. The method of producing a complex polysaccharide explained as (B), which is a method of producing a complex polysaccharide with a purity of 99% or higher by purification, and the method explained as (A) are basically Is exactly the same processing method. From this, as a result, the processing method described in (A) for enteric coating processing using fine powder of tea leaves using enteric coating material zein and ethanol aqueous solution, It can be said that this is a method for producing complex polysaccharides.

In addition, the fine powder of tea leaves obtained by pulverizing tea leaves using a jet mill in the measurement diagram shown in FIG. 12 described as (A), and zein, which is an enteric coating material, are used. The measurement of the fine powder of tea leaves that had been enteric coated, and the fine powder of tea leaves that were enteric coated using the enteric coating material zein, Although the measurement figure which measured the diameter of the particle diameter of the fine powder is not shown, it is the state of the raw material of the fine powder of tea leaves, the particle diameter is exactly the same as the diameter of the measurement figure shown in FIG. It was a diameter.

Furthermore, when extracting and depositing complex polysaccharides from bancha, sencha, green tea (hereinafter abbreviated as green tea), etc., the green tea leaves are in the form of a fine powder as small as possible. A finer powder of green tea leaves (hereinafter abbreviated as fine powder of tea leaves), which has been made finer by using a grinding tool such as a millstone or a jet mill, which has a larger area, is even more It was found that complex polysaccharides can be extracted and precipitated.

In addition, for example, rooibos tea, or turmeric tea, etc., as shown below, and then enteric coating processing using enteric coating material such as twein, rooibos tea as enteric solvent, Or, by using turmeric tea as an intestinal solvent, the main component is not decomposed in gastric juice that is strongly acidic inside the stomach, so it dissolves in a strong alkaline solution inside the intestinal tract, Rooibos tea or turmeric tea is more effective. In addition, rooibos tea or grass root bark other than turmeric tea, or herbal medicines shown below have similar effects. Rooibos tea, or mangrove, or pine nut shell,
Or green tea, or black tea, or barley tea, or barley tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea, or coffee, or a well-dried oak tree chip, or cherry Wood chips, or apple tree chips, beech tree chips, oak tree chips, walnut tree chips, hickory tree chips, maple tree chips, or oak trees , Mixed wood chips such as cherry tree, beech tree, oak tree, maple tree, or birch tree chip, or other wood chip, green tea, black tea, chlorella, chlorella tea, Tochu tea, Barley tea, brown rice tea, coffee, cocoa, octagonal fine powder,
Pine nut powder, mangrove trunk and branch and leaf powder, rose tea
Rosaceae tea, yellow scented (paicy tea), cat's claws (cat crow tea), kuzuka (kagikazura tea), tahibo tea native to the outback of the Amazon, rooibos tea native to Africa, eye drops wood tea (Megsurinoki tea), Indian native Gymnema tea, Rafu hemp tea, cod leaf tea, Iperoscio tea, Umeyama Shusui tea, Propolis tea, Reishiba tea, Chitosan tea, Sashigoka tea (Yoshiju tea), Fugen ■ tea (Pu-erh tea), turmeric tea, carrot tea, dokudami tea, tomorrow leaf tea (Ashitaba tea), candy tea tea (Achacha tea), aloe tea, ginkgo leaf tea, oolong tea, psyllium tea, oyster leaf tea, garcinia tea, Gymnema tea, guava tea, rich tea, kumazasa tea, mulberry leaf tea, shijuum tea, perilla leaf tea, jasmine tea, sugina tea, buckwheat tea, tabebuya tea, cod leaf tea, ten tea, dokudami tea, herbal tea, Ningho tea Tea), pearl barley tea, banaba tea, hub tea, loquat leaf tea, ratio tea (pai tea tea), mate tea, umeyama shusui tea, eucalyptus tea, mugwort tea, lakanka tea, rakuma tea, longi tea (longines) Tea), or ginseng, licorice, ground yellow, hunting (
Jutsu), or Chinese medicine herbal medicine, Kakkon, Toki, Pakuyaku, Ginger, Koboku, Deer, or Bushi
Hange, Daio, Kyonin (hereinafter abbreviated as grassroots bark or herbal medicine, or rooibos tea, green tea, sencha, bancha, strawberry tea, oolong tea, puer tea, turmeric tea, black tea ), As described above, for example, at the stage of fine powder of tea leaves, which are green tea, hybromellose phthalate (hereinafter abbreviated as HPMCP), twein, or shellac , Or other enteric coating materials (HPMC for short)
P) and enteric coating using an enteric coating material such as HPMCP on the surface of the fine powder of tea leaves. Apply coating. Or, at the stage of green tea leaf, which is the raw material of fine powder of tea leaves, on the surface of the green tea leaf and for the purpose of dissolving and absorbing in the intestinal tract, the digestive organ Inside the leaves, green tea leaves that have been enteric coated using HPMCP or the like are used as raw materials, and grinding means such as a millstone, ball mill, jet mill, etc. are used to remove the green tea leaves from HPMCP.
Enteric coated green tea leaves with enteric coating processed into enteric coating materials, such as enteric coating materials, etc. Fine tea leaf powder forms tablets, granules, capsules, Powders or syrups (hereinafter abbreviated as fine powder of tea leaves, or tablets, or catechin tablets or enteric solvents) are formed. Or, on those surfaces, the dosage forms that have been enteric coated using enteric coating materials such as HPMCP again are tablets, granules, capsules, powders,
Influenza, acute gastroenteritis, malaria, AIDS, sleep using an enteric solvent in the form of a syrup (hereinafter abbreviated as powdered tea leaves, tablets, or catechin tablets, or enteric solvent) Therapeutic means for preventing and treating adult diseases such as infectious diseases such as diseases, diabetes, hypertension, anti-cancer, and hay fever, and the raw materials of the pharmaceuticals.

Furthermore, by using it as an additive for candy such as cereals and chocolate, it is used as a means for developing and treating candy for the purpose of lowering blood sugar in the human body, lowering hypertension, or anticancer effect.

In addition, as described above, Mitsui Norin Co., Ltd. manufactures and sells polyphenone 70S, Taiyo Kagaku Co., Ltd., which is a fine powdered catechin purified by extracting with hot water from tea leaves. Extraction of hot water from Sanphenon BG-3, a catechin in the form of fine powder that has been purified by hot water extraction from tea leaves, which is manufactured and sold, or other tea leaves (hereinafter abbreviated as green tea) The catechin in the fine powder state that has been refined and extracted with hot water, and the residue left after purification is bancha, sencha, green tea (hereinafter, abbreviated as green tea) tea leaves, etc. For example, if the company is located in 3-47-10 Honmachi, Shibuya-ku, Tokyo, the name of the product that ITO EN Co., Ltd. manufactures and sells in plastic bottles is the purpose of manufacturing and selling green tea drinking water Left after extracting hot water from green tea leaves Coca-Cola National Beverage Co., Ltd., located in 6-2-31 Roppongi, Minato-ku, Tokyo, manufactures and sells in plastic bottles. For the purpose of manufacturing and selling green tea drinking water, put green tea leaf tea leaves or other green tea drinking water, which is the residue left after boiling hot water extraction from green tea leaves, into a container such as a plastic bottle. Remaining after hot water extraction from green tea leaves for green tea leaves for other purposes, or green tea leaf leaves remaining after extracting hot water from green tea leaves for manufacturing and sales purposes The inside of the tea leaves of green tea leaves (hereinafter abbreviated as green tea residues, or green tea leaf residues, or tea leaves), which is a residue, is formed from, for example, lipid peroxide produced by ultraviolet rays from green tea. To protect their leaves, which are leaves, In peroxidase,
It protects itself by producing vitamin E, carotenoids and vitamin C. Green tea contains a large amount of antioxidants such as catechin, beta-carotene, vitamin E, and vitamin C, which are antioxidants. However, since antioxidants are contained in the green tea leaves, which are green tea, and the tea liquid contains only a small amount, the green tea leaves, the green tea leaves, are eaten. Other than that, you can not take a large amount of antioxidants.

Furthermore, as the current means for using tea leaves as described above, (1) is discarded as residue. (2) is currently used as livestock feed. As a means of utilizing the tea husk containing a large amount of this antioxidant, the water contained in the tea husk leaves is dehydrated and dried, for example, the tea husk leaves contain. After drying the water content of the tea husk to a water content of 0.6% or less, the well-dried tea husk leaves are crushed using a jet mill or ball mill. The size of the tea leaves after processing into a fine powder of tea leaves (hereinafter abbreviated as fine powder of tea leaves) with a diameter of 50 µm or less or 50 µm or more. By using enteric coating materials such as HPMCP, Twein, or shellac (hereinafter abbreviated as Twein) for the fine powder, the leaves of the tea husks are enteric-coated to produce enteric solvents. Of tea leaves taken directly from the intestinal tract into the human blood Antioxidants such as catechin, beta carotene, vitamin E, vitamin C, which are antioxidants contained in the fine powder of tea leaves in the process of breaking down the fine powder in the liver and kidney, Or L-arabinose which is a complex polysaccharide,
In addition to complex polysaccharides such as D-ribose and D-glucose, or substances other than complex polysaccharides such as D-mannose and L-sorbose, which have an effect of lowering blood glucose, substances having an effect of lowering blood glucose in human organs. It is intended to produce in a certain liver and kidney.

The complex polysaccharide having the effect of lowering blood glucose that lowers blood glucose level in the blood is a generic term for substances having a molecular weight of 40,000 and L-arabinose, D-ribose, and D-glucose as constituent sugars. To obtain a complex polysaccharide. In addition to complex polysaccharides, D-
Hypoglycemic substances that have the effect of lowering blood glucose levels in blood including mannose and L-sorbose are collectively referred to as complex polysaccharides.

Further, the fine powder of tea leaves containing a large amount of complex polysaccharides as described above, the dosage form is tablets, granules, capsules, syrups, and powders (hereinafter abbreviated). And tablets).

In addition, the powdered form of tea leaves made from enteric coating material using enteric coating material made from fine powder of tea leaves leaves the form of tablets, granules, capsules, syrup. And powder (hereinafter abbreviated as tablets or tea husk tablets), or tablets that have undergone enteric coating on them, are orally administered to the leaves of tea husks in the intestinal tract, the digestive tract. Tea powder with a particle diameter of 50 μm or less or 50 μm or more is taken into the blood of the human body and taken into the blood to make tea in the liver and kidney of the human body The purpose is to lower the blood sugar level in the blood by decomposing fine powder of husk leaves and producing complex polysaccharides contained in the fine powder of tea husk leaves in the liver and kidney Hypoglycemic agents, for example, dosage forms are injections It is possible to lower the blood glucose level similar to that of a hypoglycemic agent such as buformin hydrochloride, tributamide, or exenatide in a preparation intended for oral administration or insulin. However, the difference between the use of the complex polysaccharide contained in the fine powder of tea leaves for the purpose of lowering the blood sugar level in the blood is that In the fine powder, hypoglycemic agents such as insulin, buformin hydrochloride, tributamide, and exenatide, which are the above hypoglycemic agents, may cause lactic acidosis, and each has many side effects.

Further, as described above, fine powder of tea leaves, fine powder of tea leaves, or fine powder of tea leaves that have been enteric coated using enteric coating materials such as twein, Or, the dosage form is tea leaves that have been enteric coated using enteric coating materials such as twein (hereinafter abbreviated as fine powder of tea leaves or tea leaves). , HPMCP, again on the surface of granules, capsules, powders, syrups, or their
Or dosage forms that have been enteric coated using enteric coating materials such as Twein or Shellac (hereinafter abbreviated as HPMCP) are tablets, granules, capsules, powders, syrups (hereinafter abbreviated). Table 19 shows a reference example of a blending table of blending ratios of raw materials in the case of forming a tablet, a granule, a tea-shell tablet, or a tea-husk granule.

In addition, as described above, catechin with a coating obtained by performing enteric coating using HPMCP, which is a coating material of enteric solvent, or zein, or shellac (hereinafter, abbreviated as zein), as described above. Or tea leaves coated with enteric coating using a catechin (hereinafter abbreviated as catechin or coated catechin) or enteric coating material such as zein. Or a tea leaf fine powder (hereinafter abbreviated as catechin, or tea leaf fine powder, or tea husk) which has been enteric coated using an enteric coating material such as twein. The dosage form is a tablet, granule, capsule, powder, syrup, or hybromellose powder on or in the surface thereof. Enteric coating processing using enteric coating materials such as oxalate (hereinafter abbreviated as HPMCP), zein, or shellac (hereinafter abbreviated as HPMCP) to produce enteric solvent Therefore, even if tablets or granules made of catechin, fine powder of tea leaves, fine powder of tea leaves, or granules are chewed in the mouth of the human body, they dissolve in the gastric juice that is the digestive organ. It becomes a tablet or granule of the nature that dissolves in the inside of the intestinal tract without losing it, so that the tablet or granule of the nature of such enteric solvent is again a sugar-coated tablet or a chocolate-flavored sugar-coated tablet. It becomes a property that can be absorbed into the body in the intestinal tract while it is a medicine that can be taken or eaten by infants, children, and adults, or candy, so that infection, hypertension, Cancer, flowers There are advantageous effects that the treatment means intended for the treatment of such diseases.

Furthermore, enteric coating is processed using enteric coating materials such as HPMCP, which is enteric coating material, or catechin or enteric coating material such as shellac (hereinafter abbreviated as HPMCP). Table 20 and Table 21 below show reference examples of the mixing ratio of raw materials in the case where the catechin (hereinafter abbreviated as catechin or coated catechin) is used to form tablets or granules. Show. In the case of tablets, the raw material names are shown in Table 20. In the case of granules, the raw material names are shown in Table 21.

* HPC-L: Hydroxypropyl cellulose
HPMCP: Hybromellose phthalate

In addition, Table 15 and Table 16, which are the contents of the report described above, which was jointly researched with Associate Professor Akira Ishii of Hamamatsu Medical University, are shown in Table 15. The combination effect of artesunate (hereinafter abbreviated as ART) and catechins BG-3 and ART, or 70S and ART is the suppression of protozoan growth in the combination group compared to the group administered ART alone on day 7 after infection. Evaluated.
Intraperitoneal administration of catechins at a daily dose of 25 mg / kg body weight showed no side effects. The report in Table 15 shows that catechins BG-3 and ART or 70S and ART combined showed significant suppression of protozoan growth.

Furthermore, the experimental results in Table 16 were evaluated by comparison with the survival days of the chloroquine (hereinafter abbreviated as CQ) single administration group. Catechin BG-3 and CQ, or 70S and CQ combination counties have a survival time of C
The report in Table 16 shows that there was a life-prolonging effect because it survived longer than Q alone.

In addition, when catechins and ART or catechins and CQ shown in Table 15 and Table 16 described above are used in combination, the sensitivity is higher than that of single administration of ART or CQ. It was found that the effect of suppressing the growth of protozoa or the effect of prolonging life by increasing the sensitivity as a drug.

Furthermore, when the catechins and ART shown in Tables 15 and 16 or the catechins and CQ described above are used in combination, the reason for the further increase in sensitivity is that the malaria parasite grows. The place is inside the red blood cells. The important substance that makes up red blood cells is iron (hereinafter,
Abbreviated as Fe). The feature of this catechin is that it is a substance that easily undergoes a condensation reaction with the Fe content, and if the proliferation of malaria parasites is suppressed inside the erythrocyte, It is possible to explain the reason why catechins and ART, or catechins and CQ are used in combination, by causing a condensation reaction to form a bond, the sensitivity becomes high.

In addition, from the explanation above, if catechins and ART, or catechins and CQ are used together, Fe content is intervening as the reason for increased sensitivity.
It is more effective to use ART and Fe or CQ and Fe together than to use ART or CQ alone by using CQ and Fe. The results of experiments in which catechins and ART or catechins and CQ are used in combination in the reports shown in Tables 15 and 16 indicate that the sensitivity can be increased.

Conclusion (1) suggests that the development of drugs that mix ART and Fe or the development of drugs that mix CQ and Fe has the effect of increasing sensitivity. There are 16 reports.

As a conclusion (2), the development of a drug that mixes ART or CQ with a substance that causes a condensation reaction with Fe components other than ART or CQ and catechins and has the effect of increasing sensitivity is effective. The reports in Table 15 and Table 16 suggest this.

In addition, the following describes the growth of malaria parasites and the life of malaria parasites for the purpose of producing a vaccine whose disease name is an antibody against malaria using catechins or other substances. .

"Proliferation and life of plasmodium"
In humans, malaria parasites asexually reproduce (shizogonique). When an infected mosquito sucks blood, the malaria protozoa lurking in its salivary glands, the fig-type sporozoite (sporozoite)
s 8-12μm x 1μm) enters the human body together. This can only survive about half an hour in the blood circulation. Those that have reached the liver quickly begin first extra-erythroid development (synonyms; pre-erythroid development, first tissue division). Sporozoites invade hepatocytes where they are renamed cryptozoites. It develops further and the nucleus divides, and after about a week, a blue body (corpsbleu) containing mature merozoites is formed. It dyes basophil blue, is 40-100 μm in size, contains many nuclei, breaks the host hepatocytes, and releases merozoites back into the peripheral blood. For the most part, the blue body rides in the bloodstream, enclosing a lot of merozoites, and it opens and ruptures during the treatment of capillaries in sinusoidoids. This initiates the first asexual reproduction in the blood. During this period, the infection with P.vivax and P.ovale continues to dormancy in the presence of several cryptozoites (months to years) with the original strain genetically. This dormant parasite is referred to as hypnozoites and is also referred to as second erythrocytic development or delayed type (synonyms: second tissue division). This is the source of a new blue body,
Several months to several years after the initial infection, merozoites are released again into the blood, and divisions are seen in red blood cells again. There appear to be two populations of sporozoites. One grows immediately and changes to a blue body in the liver. The other is a hypnozoite that stays for a certain period of time and rests in hepatocytes. P.falciparum (and certainly P.marariae) does not cause hyponozoites or secondary tissue division. In blood, asexual reproduction in erythrocytes (synonyms: erythrocyte division) occurs. Each merozoite uses endocytoses to invade red blood cells and become nutrients (t
rophozoite or transfusion). It is 2-3 μm in size and has large nutrient vacuoles in it, which push the cytoplasm and nucleus into the blood. Nutrients undergo nuclear fission and schizophrenia (sch
izonte), which contains malaria pigments or hemozoites. Nuclei divide, each surrounded by a broad cytoplasm, mature mitotic or roseid (corps en rosace
) Is formed. In parallel, the hemoglobin of the infected erythrocytes is transformed, and Schuffner spots (
P.vivax, P.ovale), Maurer spots (P.falciparum), or none (P.malariae) are observed. The cram school division matures, expands and bursts. This coincides with the fever phase, and the released merozoites invade uninfected erythrocytes and cause new intra-erythroid growth. The duration of each type of red growth is 48 hours for P. vivax and P. ovale and P. falciparum and 72 hours for P. marariae. When the rose-like body ruptures, hemozoites are released, which are the polynuclear neutrophils and monocytes in the blood,
They are phagocytosed by bone marrow, spleen, and liver histocytes (Kupffer cells) to produce melanin. Anop pondering on the lake
heles (Anopheles mosquitoes) from the blood of their favorite foods, vegetatives, juvenile divisions, mature divisions, reproductive mothers (gameto
cytes) is taken into the body. Asexual reproductive protozoa are digested and only the reproductive maternal body continues to develop. In the mosquito stomach, the male reproductive maternal body is exflagellated to become a reproductive body, and the female reproductive body expels chromatin bodies. Female reproductive bodies are fertilized and migrated eggs or ookinet bodies (ookinet
e) through the stomach wall of Anopheles and adhere to its outer wall. So I changed to an ostrich,
Make sporozoites. Sporozoites released by the rupture of the Ostrich prefer to enter the saliva of Anopheles. Sporozoites last for 10-40 days, depending on temperature and malaria species. It is 12 days in P.falciparum in tropical Africa. It is P.vivax that growth stops
At 16 ° C and at 18 ° C for P. falciparum. After all, it is classified into three developmental stages.
Asexual reproduction in the body of Anopheles, asexual reproduction in the liver and accumulation of dormant bodies Asexual reproduction and early sexual reproduction in human blood vessels and red blood cells

The sporozoites described above are used to form malaria parasites that inactivate malaria parasites and eliminate toxicity for the purpose of acquiring autoimmunity against malaria in the human body. The body stays sleep for a period of time (sporozoites), or the state of cryptozoites where the sporozoites have entered the liver cells and changed their name, or merozoites, or cryptozoites. Or, at the stage of hypnozite, a body-sleeping parasite, Table 1, Table 5,
And catechins shown in Table 8 or other catechins (hereinafter abbreviated as catechins) to cause a condensation reaction, and malaria parasites sporozoites, merozoites, cryptozoites, and hypnosoites (abbreviated as cryptozoites). Or a malaria parasite that has been inactivated or attenuated by deactivating the activity of the malaria parasite (hereinafter referred to as a pseudo-malaria parasite), using a pseudo-malaria parasite as an antigen, Explain the steps taken until the human body acquires immunity to malaria parasites. The order in which the human body memorizes immunity, the immune memory is established, and the human body acquires immunity acquires the immunity in the following order (1) to (4).

As (1), a pseudo-malaria parasite (hereinafter abbreviated as antigen) that is an antigen that is administered orally or intravenously (hereinafter abbreviated as oral administration) to the human body. And phagocytic cells are bred.

As for (2), phagocytic cells present a part of the antigen to helper T cells.

As (3), the helper T cell further transmits information to the B cell, and causes the B cell to differentiate into a plasma cell having an antibody production ability capable of producing an antibody.

As for (4), plasma cells produce antibodies to form antigen-antibody complexes. In general, it takes about one week from the initial infection until the above immune response is established.

In addition, when the same antibody described above is first infected in the human body and the antigen has invaded the human body for the second time, the immune memory is established. Plasma cells produce antibodies and form antigen-antibody complexes.

For the purpose of acquiring autoimmunity against malaria in the human body as described above, the malaria parasite (hereinafter abbreviated to be abbreviated as abbreviated) is inactivated by activating the activity of the malaria parasite. The sporozoites stage to form a malaria parasite), or the cryptozoites stage where the sporozoites have entered the liver cells and changed their name, or merozoites or cryptozoites for a period of dormancy to continue. Alternatively, at the stage of the hypnozoite that is a body-sleeping parasite, pseudo-malaria in which the activity of malaria parasite has been inactivated by using a substance other than the catechin described above or other means to remove toxicity Substances according to (1) to (27) and (28) for forming a protozoan vaccine and administering it orally or intravenously (hereinafter abbreviated as oral administration) , And other means are used to form pseudo-malaria parasites that are administered orally to produce autoimmunity that is an antibody of the malaria parasite.

As (1), formalin is used to inactivate the activity of malaria parasite to remove toxicity, and then purified to form a pseudo-malaria parasite.

As (2), using a methyl alcohol aqueous solution, an ethanol aqueous solution, a saline solution, and an aqueous solution in which sugar is dissolved, the activity of the malaria parasite is inactivated and the toxicity is removed, followed by purification to form a pseudo malaria parasite .

As (3), for example, alkaline extraction using an alkaline aqueous solution having a PH concentration of 7.5 or higher, or 8.0 or higher, or an alkaline aqueous ethanol solution (hereinafter referred to as an aqueous solution or an aqueous ethanol solution) is performed. The active ingredient can be easily extracted by inactivating the malaria parasite and removing the toxicity, followed by purification to form a pseudo-malaria parasite and alkaline extraction.

As (4), the malaria parasite is heated to 60 ° C. or more to inactivate the activity of the malaria parasite to remove toxicity, and then purified to form a pseudo malaria parasite.

As (5), the malaria parasite is spray-dried or freeze-dried to inactivate the activity of the malaria parasite to remove toxicity, and then purified to form a pseudo malaria parasite.

As (6), the malaria parasite is dipped in liquid nitrogen and freeze-dried to inactivate the activity of the malaria parasite to remove toxicity, and then purified to form a pseudo malaria parasite.

As for (7), a large amount of female mosquitoes infected with malaria parasites are cultured and proliferated,
It is a malaria protozoa lurking in the mosquito's salivary glands, ie, a fig-type malaria protozoa
For the purpose of extracting the malaria parasite which is 8-12 μm × 1 μm sporozoite, a living mosquito is treated with ethanol aqueous solution, formalin solution, physiological saline, sugar water, and aqueous solution (hereinafter abbreviated,
Malaria protozoa lurking in the salivary glands of mosquitoes by mixing live mosquitoes inside the solution and applying vibrations such as ultrasonic waves from the outside, for example, alkaline ethanol aqueous solution with a PH concentration of 8.0 or more ( Hereinafter, it is discharged into an aqueous solution such as an ethanol aqueous solution or an alkaline ethanol aqueous solution for short. The malaria parasite that is lurking in the salivary glands of mosquitoes is spit out in an aqueous solution such as an ethanol aqueous solution, and then the malaria parasite that is dissolved in the aqueous solution such as an ethanol aqueous solution is filtered using a filter or the like. Recover the carcass. The recovered dead carcass of malaria parasite is made into a fine powder state, or dried by a drying means such as freeze drying, and then the malaria parasite carcass in a fine powder state is orally administered or intravenously The human body that ingested the carcass of the malaria parasite by internal administration vaccines the protein that constitutes the carcass of the malaria parasite or the glycoprotein (hereinafter abbreviated as protein) as a part of the protein of the malaria parasite By recognizing it as an antigen having the same effect as the above, the human body purifies and uses the dead body of the malaria parasite as a means of acquiring the human body with autoimmunity whose disease name is an antibody against malaria.

(8) As described above, after the malaria parasite carcass was collected by filtering the malaria parasite carcass using an aqueous solution such as an ethanol aqueous solution and filtering the malaria parasite carcass using a filter, Use the corpse in its raw state, or dry it using freeze-drying means such as freeze drying, and then dry the dead malaria parasite into fine powder using a mortar, mortar, or jet mill. After that, the dead body of the malaria parasite is dissolved in physiological saline (hereinafter abbreviated as water for injection), and a 0.45 μm PTFE filter or P
Self-administered water for injection, in which the dead body of malaria parasite is dissolved by using a VDF filter, is administered intravenously or orally to the human body, and the disease name is an antibody against malaria As a means for causing the human body to acquire immunity, a malaria protozoan dead body is purified and used as a means for causing the human body to recognize various substances such as proteins in which the dead body of the malaria parasite is dissolved as an antigen.

As for (9), the disease name is a metamorphic tripomastogote transformed from epimastigotes, that is, epimastigotes lurking in the salivary glands of the flyfly, by breeding a large number of the fly flies that mediate sleeping sickness. This metacyclic tripomastigote infects humans and becomes trypanosoma protozoa (hereinafter abbreviated as trypanosoma). For the purpose of extracting and collecting Trypanosoma protozoa that are 20-30 μm in length and 1.5-3.5 μm in width and are spindle-shaped, the living fly flies are treated with ethanol aqueous solution, formalin solution, physiological saline. Trypanosoma protozoa lurking in the salivary glands of the flyfly by mixing live flyfly inside the sugar water and aqueous solution (hereinafter abbreviated as aqueous solution) and applying vibrations such as ultrasonic waves from the outside. Exhale into an aqueous solution such as an alkaline ethanol solution with a PH concentration of 8.0 or higher. Trypanosome protozoa lurking in the salivary glands of the fly fly after evacuating the inside of an aqueous solution such as an ethanol aqueous solution, and then filtering the Trypanosoma protozoa dissolved in an aqueous solution such as an ethanol aqueous solution using a filter etc. Purify and recover the carcass. The recovered corpse of Trypanosoma protozoa collected in a fine powder state or dried by drying means such as freeze-drying and then orally administered into a pulverized Trypanosoma protozoan carcass or intravenously The human body that ingested the corpse of Trypanosoma protozoa by internal administration of the protein, or glycoprotein (hereinafter abbreviated as protein) constituting the corpse of Trypanosoma protozoa, is a part of the protein of the Trypanosoma protozoa. By recognizing it as an antigen that has the same effect, the human body uses the dead body of Trypanosoma protozoa as a means for the human body to acquire autoimmunity, whose disease name is an antibody against sleeping sickness.

(10) As described above, the Trypanosoma protozoan carcass was recovered by filtering the Trypanosoma protozoan carcass using a filter using an aqueous solution such as an ethanol aqueous solution. The carcasses are dried using a drying means such as freeze drying, and the dried cartilage of Trypanosoma protozoa is made into a fine powder using a stone mortar, mortar, jet mill, or the like, and further, physiological saline ( The corpse of Trypanosoma protozoa in a fine powder state is dissolved in water for injection (hereinafter abbreviated as water for injection), and filtered using a 0.45 μm PTFE filter or PVDF filter. Dissolved water for injection is administered intravenously, subcutaneously, or orally to the human body to provide autoimmunity with an antibody against sleeping sickness. As a means to acquire the human body, trypanosoma protozoa are caused to the human body by using various dead substances such as proteins contained in the trypanosoma protozoan as antigens and using the corpse of trypanosoma protozoa as a means to recognize the human body The body of trypanosoma protozoa is purified and used as a means for the human body to acquire autoimmunity, which is an antibody against sleep diseases that develop in

(11) As described above, the disease name is malaria, and the disease name is sleep disease,
Leishmaniasis, which is an infectious disease caused by a protozoan borne by a moth fly (hereinafter abbreviated as a protozoan moth fly), or a protozoa possessed by a turtle (hereinafter abbreviated as a protozoan moth) Chagas disease, which develops due to the occurrence of protozoa, is the same as that described above, in which the malaria parasite or trypanosoma protozoa is propagated and proliferated, and the malaria parasite or trypanosoma protozoa is collected. Propagation or propagation of protozoa or turtle protozoa, for example, using a filter or the like for protozoa protozoa or protozoan protozoa dissolved in an aqueous solution of alkaline ethanol or the like having a PH concentration of 8.0 or more Filtration is carried out to purify and recover the body of moth fly protozoa or turtle protozoa. The recovered dead body of the flying moth parasite, or the raw turtle protozoa, is made into a fine powder state or dried by a drying means such as freeze drying, and then the dead body of the flying moth protozoa is made into a fine powder state, Alternatively, the human body that ingests the body of the moth moth parasite or the turtle protozoa by oral administration, subcutaneous injection, or intravenous administration of the protozoan protozoa constitutes the corpse of the moth fly protozoa or protozoan protozoa. The human body recognizes the protein or glycoprotein (hereinafter abbreviated as "protein") as the antigen that has the same effect as that of the vaccine. As a means to make the human body acquire autoimmunity, which is an antibody against leishmaniasis or the disease name Chagas disease Youbae protozoa, or to use the corpse of the assassin bug protozoa.

(12) As described above, the corpse of the moth fly moth or the turtle protozoa is used in an aqueous solution such as an ethanol aqueous solution, and the corpse of the moth fly moth or the turtle protozoa is filtered using a filter. After recovery, the body of the moth fly protozoa or the turtle protozoan was dried using a drying means such as freeze drying, and the dried moth fly protozoa or the body of the turtle protozoa was removed with a millstone, mortar, Alternatively, after making fine powder using a jet mill or the like, further dissolve the dead body of the moth parasite or the turtle protozoa in a fine powder state in physiological saline (hereinafter abbreviated as water for injection). Filtration using a filter made of μm PTFE or a filter made of 0.45 μm PVDF to dissolve corpse of larvae or turtle protozoa Water is injected intravenously, subcutaneously, or orally into the human body to acquire autoimmunity in the human body with the disease name Leishmaniasis or the disease name being an antibody against Chagas disease. As a means to make the human body recognize as a means to make the human body recognize various miscellaneous substances such as proteins that are dissolved by the protozoan moth parasite, or the corpse of the turtle protozoan, , Leishmaniasis, the name of the disease that develops on the human body due to protozoa
Or as a means for causing the human body to acquire autoimmunity, which is an antibody against an infectious disease caused by a protozoan such as Chagas disease, the protozoan parasite or the dead body of the turtle protozoa is purified and used.

As (13), schistosomiasis is a disease caused by adult parasites in the veins. Schistosoma-haematobium belonging to urinary schistosomiasis (pathogen is Schistosoma-haematobium), S. mansoni belonging to intestinal schistosomiasis, S. japonicum
), Mekong schistosomiasis (S. mekongi), and intercalum schistosomiasis (S. intercal)
atum), and people infect freshwater in rivers, lakes, and swamps. This disease is considered to be the second most important parasitic disease in the endemic area after malaria in terms of socio-economic and public health. In Japan, schistosomiasis has occurred frequently in certain areas, but now it has been eradicated and no new cases have been seen. Recently, however, the importance of imported infectious diseases is increasing as Japanese people travel to and stay in endemic areas, and foreigners visit Japan. The need for appropriate medical care at domestic medical institutions has increased. doing.

As for (14), as described above, the schistosome-infected animals include humans in Bilharzia schistosomiasis, rodents and baboons in Schistosoma mansoni, and many animals including horses and dogs in Schistosoma japonicum. It is. Infected animals, including humans, excrete eggs in the urine and stool, but the size of the eggs is 110-170 × 40-70 μm in Bilharz and Manson schistosomiasis. Has thorns on the side. Schistosoma japonicum eggs are 80 to 100 × 40 to 60 μm, have a slightly short major axis, have a round shape, and have small spines on the sides. Mekong schistosome eggs are similar to Japanese schistosomiasis eggs, and intercolor Zum schistosome eggs are similar to Bilharz schistosomiasis eggs. Miracidium is formed in worm eggs, which invades freshwater shellfish as an intermediate host in water. Each schistosomiasis parasitizes different freshwater shellfish, but Bilinus and Bilharz and intercolor zum schistosomiasis
In the genus, Schistosoma mansoni Biomphalaria, in Schistosoma japonicum Oncomelania (Miyairi),
In the Mekong schistosomiasis, it is Tricura aperta. In freshwater shellfish, it grows into cercariae through a sporocyst. Cercaria is approximately 0.3mm long and has a bifurcated tail that swims in fresh water and penetrates human skin into the blood. After that, it passes through the lungs in the human body and then settles in the vein, but it becomes an adult after passing through the stage of cystosomule.

As (15), the schistosome adult described above is a hermaphrodite, and the female worm is parasitic on the vein in the form of holding a male worm. The body length is 10-15 mm for Schistosoma mansoni and 16 for females.
~ 20 mm, 6-10 mm of Schistosoma mansoni, 7-16 mm of females, 12 of males of Schistosoma japonicum
~ 20mm, female worm is about 25mm. The veins in which these adults settle are characteristic and cause characteristic lesions, that is, urinary schistosomiasis is mainly in the pelvic veins, especially around the bladder,
Intestinal schistosomiasis parasitizes portal vein techniques (enteric veins). Eggs are deposited mainly on the bladder wall and ureter wall in the former case, and on the intestinal wall and liver in the latter case. Adult life span is usually 3-5 years, but in rare cases can be as long as 30 years.

(16) As described above, schistosomiasis Bilharz, schistosomiasis mansoni belonging to intestinal schistosomiasis, schistosomiasis japonica, schistosomiasis mekong, and schistosomiasis intercalatum (hereinafter abbreviated) Schistosomiasis), etc., grows in cercariae through sporocysts in Miyairigi or other freshwater shellfish (hereinafter abbreviated as freshwater shellfish). For the purpose of collecting cercariae with a diameter of 0.3 mm, the cercariae are propagated in large quantities to proliferate, and for the purpose of collecting cercariae from freshwater shellfish contaminated with cercariae, an aqueous ethanol solution, A living freshwater shellfish is placed inside a formalin solution, physiological saline, sugar water, and an aqueous solution (hereinafter abbreviated as an ethanol aqueous solution or an alkaline ethanol aqueous solution), and vibrations such as supersonic vibration from the outside. Cercaria lurking inside the freshwater shellfish into an aqueous solution such as an ethanol aqueous solution. Or, after crushing freshwater shellfish infected with cercariae in an aqueous solution such as an ethanol aqueous solution, cercaria dissolved in an aqueous solution such as an ethanol aqueous solution is pulverized, and 0.45μ
Filter with a PTFE filter or 0.45 μm PVDF filter to collect fine powder of cercaria carcasses. The human body that ingested the fine powder of cercaria carcass by ingesting the collected fine powder of cercaria carcass orally, subcutaneously, or intravenously. Protein or glycoprotein (hereinafter referred to as
The human body recognizes the protein of a part of schistosomiasis that causes schistosomiasis as an antigen that is similar to the effect of the vaccine, so that the human body is an antibody against schistosomiasis. As a means to make the human body acquire autoimmunity, the fine powder of cercaria carcass is purified and used.

(17) As for onchocerciasis, it is caused by a parasite called Onchocerca volvulus. These parasites are classified into the superfamily of filamentous worms (collectively called filariae), and become larvae (infectious larvae) that can be infected in the body of the insect, the vector insect.
Infection occurs when this fish pierces the human skin and sucks blood. Infected larvae continue to produce microfilaria larvae in the blood after becoming adults on human skin. The microfilariae enter the body of the blackfish during the blood sucking, and become infected larvae again, forming a ring of infection.

(18) As described above, onchocerciasis is a larva (hereinafter abbreviated) that is capable of infecting the body of an insect that mediates the rotifer (hereinafter abbreviated as filaria).
Infected larvae). For the purpose of collecting the infected larvae, we used a cocoon that has been infected with filariae. Put live buoy into saline, sugar water, and aqueous solution (hereinafter abbreviated as ethanol aqueous solution or alkaline ethanol aqueous solution), and give vibration such as ultrasonic vibration from outside to the inside of the buoy The infected larva lurking in the water is spit into an aqueous solution such as an ethanol aqueous solution. Alternatively, the infested larvae are crushed inside an aqueous solution such as an ethanol aqueous solution, and then the infected larva dissolved in an aqueous solution such as an ethanol aqueous solution is crushed to obtain 0.45 μm PTFE. Made of filters, or 0
Filter using a .45μm PVDF filter to recover the fine powder of dead larvae.
The human body that ingested the fine powder of infected larvae by oral administration, subcutaneous injection, or intravenous administration of this infected larvae fine powder, Recognizes a protein of a part of the infected larva that causes Onchocerca as an antigen that is similar to the effect of the vaccine. As a means of causing the human body to acquire autoimmunity, which is an antibody against the above, a fine powder of dead bodies of infected larvae is purified and used.

As for (19), convolutive filariasis is a dermatosis under the epidermis caused by Onchocerca volvulus.
More than 15 million people are infected. Filaria is transmitted by small moths, and their larvae grow rapidly on the riverside. Eye complications are serious, and the nickname “River Blindness” comes from there. It is particularly distributed in Black Africa and has become a serious obstacle to the development of fertile watersheds.

(20) As described above, the ocular complications are larvae (hereinafter abbreviated) that can be infected in the body of small pupae that mediate rotiferous (hereinafter abbreviated as Filaria). Infected larvae). In order to collect the infected larvae, a small cocoon infected with filariae is used to reproduce the infected larvae in large quantities, and the infected larvae are collected for the purpose of collecting the infected larvae. Put a small living bag inside physiological saline, sugar water, and aqueous solution (hereinafter abbreviated as ethanol aqueous solution or alkaline ethanol aqueous solution) to give vibration such as ultrasonic vibration from the outside. Infected larvae lurking inside a small cocoon are spit into an aqueous solution such as an ethanol aqueous solution. Or, after pulverizing a small cocoon infected with an infected larvae in an aqueous solution such as an ethanol aqueous solution, pulverize the infected larva dissolved in an aqueous solution such as an ethanol aqueous solution to obtain 0.45 μm. Using a PTFE filter of 0.45 μm or a PVDF filter of 0.45 μm, a fine powder of dead larvae of the infected larvae is collected. The collected body powder of infected larvae is administered by oral administration, subcutaneous injection, or intravenous administration of the collected fine powder of infected larvae. By recognizing a protein or glycoprotein (hereinafter abbreviated as protein) that constitutes a part of the infected larva causing the rotiferous worm as an antigen that is similar to the vaccine effect, The human body uses a purified powder of dead larvae of infected larvae as a means for the human body to acquire autoimmunity, the disease name of which is an antibody against rotiferous worms.

As for (21), Medinaminosis (Dracunculose, dracontiase) is an helminthiasis in Asia and Africa.
It is derived from the nematode medinensis (in Latin, 《Medinah, the devil of Saudi Arabia, the second city of Mahomed ’s tomb》). This is also called the medina filamentous, guinea, and nigiri. It has been put into the group of filamentous worms according to clinical symptoms, but has zoologically different characteristics. Although this parasitic disease generally shows spontaneous remission, it causes long-term physical disability, and many of the farmer's population is often unable to work or suffers from disability during the farming season. Too little is known that the disease is causing disaster in the tropical and subtropical regions of Asia and Africa. The number of affected people is estimated at 50 million, 1/3 in Africa and 2/3 in Asia.

As (22), as described above, medinatosis develops in nematodes (hereinafter abbreviated as medina filamentous insects), which are also referred to as medina filamentous insects, guinea insects, and grip string insects. do. An aqueous ethanol solution, formalin solution, physiological saline, sugar water, and an aqueous solution (hereinafter abbreviated as an ethanol aqueous solution or an alkaline solution) for the purpose of collecting the medina filamentous worms which have been propagated in large quantities and have grown. A live mezzina filamentous worm is put into the inside of the aqueous solution) and pulverized into a fine powder, and then the fine powder of the medina filamentous worm dissolved in an aqueous solution such as an ethanol aqueous solution is made of 0.45 μm PTFE The filter is collected using a filter of 0.45 μm or a PVDF filter, and the fine powder of dead bodies of Medina is collected. The human body that ingested the fine powder of medina filamentous carcass by oral administration, subcutaneous injection, or intravenous administration of the collected fine powder of medina filamentous worms, By recognizing the protein or glycoprotein (hereinafter abbreviated as protein) of the fine powder as a antigen that is similar to the vaccine effect, the human body recognizes a protein in a part of the fine powder of Medina The human body uses a purified fine powder of the dead bodies of Medina filamentous worms as a means for causing the human body to acquire autoimmunity, whose disease name is an antibody against medinaminosis.

As for (23), the supplementary explanation of the contents explained above is that malaria protozoa lurking in the salivary glands of mosquitoes, trypanosoma protozoa lurking in the salivary glands of fly flies, or sand flies flies mediated by sand flies Protozoa, or turtle protozoa that mediate turtles,
Or mansoni schistosomiasis, Japanese schistosomiasis, Mekong schistosomiasis, parasites that cause intercalatum schistosomiasis, or infected larvae that lie in the body of the fly that causes onchocercosis, When efficiently extracting substances similar to antigens from dead bodies such as infected larvae that lurk in the body of small flies that cause complications, or medina filamentous worms that cause medinas, for example, When alkaline extraction is performed using an alkaline aqueous solution having a PH concentration of 7.5 or more and 8.5 or more, or an alkaline ethanol aqueous solution having a PH concentration of 7.5 or more and 8.5 or more, a substance similar to an antigen can be efficiently extracted.

(24) includes malaria parasites, trypanosoma protozoa, scorpion fly protozoa, parasites that cause schistosomiasis, parasites that cause schistosomiasis, infected larvae, and silkworms (hereinafter abbreviated as protozoa, parasites). In order to efficiently extract substances similar to antigens from dead bodies such as infected larvae and filamentous worms, the protozoa, parasites, infected larvae and filamentous worms are thoroughly dried and pulverized. After powdering, alkali-extracted substance similar to antigen from dead bodies such as protozoa using alkaline aqueous solution or alkaline ethanol aqueous solution, then 0.45μm PTFE filter, or 0.45μm Using a substance similar to the antigen filtered using a PVDF filter, etc. as a vaccine, for example, intravenously administered to the human body as a preventive measure for disease name, subcutaneous injection By performing injection, intraperitoneal administration, and oral administration (hereinafter abbreviated as subcutaneous injection), the human body produces antibodies against malaria parasites. Even if you enter, the human body will be able to defend the human body by killing the malaria parasite by self-immunity.

(25), as described above, malaria parasite, trypanosoma protozoa, scorpion fly protozoa, sand turtle protozoa, parasites, infected larvae and medina filamentous worms (hereinafter abbreviated as protozoa, parasites, infected larvae, Substitutes for mosquitoes with malaria parasites in the salivary glands, or fly flies with trypanosoma protozoa in the salivary glands, or fly moths with protozoan parasites lurking in the salivary glands, or protozoan protozoa with salivary glands Turtles lurking in the sea, freshwater shellfish such as Miyairisu infested with parasites, insect fly that carries infected larvae, small flies that carry infected larvae, or medina that carries filamentous worms Filamentous insects (
In the following, mosquitoes, swallows, sand flies, sand turtles, shrimp shellfish, freshwater mussels, flyfish, flies, and medina filamentous worms) are thoroughly dried, and then an aqueous solution made alkaline or an aqueous ethanol solution made alkaline , Dried and crushed freshwater shellfish such as mosquitoes, swallows, sand flies, sand turtles, or shrines, or shellfish, fly, or flies, or filamentous worms to make fine powder After alkali-extracting a substance similar to the antigen from the dead body, using a substance similar to the antigen filtered using 0.45 μm PTFE filter or 0.45 μm PVDF filter as a vaccine, For example, by administering intravenous, subcutaneous injection, intraperitoneal administration, orally (hereinafter abbreviated as subcutaneous injection) to the human body as a means of preventing malaria Since the human body will produce antibodies against malaria parasites, the human body will protect the human body by killing the malaria parasites by autoimmunity even if the malaria parasite enters the human body. Can be done.

(26) As described above, as a means for preventing dengue fever, Japanese encephalitis, and yellow fever (hereinafter abbreviated as dengue fever), infection with a causative virus of a pathogen that develops dengue fever Mosquitoes that have been cultivated and grown, dried mosquitoes that transmit dengue fever, dried and pulverized into fine powder, then an alkaline aqueous solution or an alkaline ethanol aqueous solution Use a substance similar to the antigen from the dead body of the mosquito, and then extract the substance similar to the antigen filtered using 0.45μm PTFE filter or 0.45μm PVDF filter. When used as a vaccine, for example, when the name of the disease is administered intravenously, subcutaneously, intraperitoneally, orally (hereinafter abbreviated as subcutaneous injection) to the human body as a means of preventing dengue fever Because the human body will produce antibodies against dengue fever, even if the human body dengue fever virus enters the human body, the human body will kill the dengue fever virus and kill the human body You will be able to defend.

(27) As described above, the mosquitoes infected with malaria parasites, the fly flies infected with trypanosoma protozoa, the fly flies infected with protozoa flies, or the protozoa A freshwater shellfish such as Miyairisu, or a small fly flies infested with an infected larva, or a medina fungus infested with a filamentous worm. Or mosquitoes infected with dengue causative virus, mosquitoes infected with Japanese encephalitis virus, or mosquitoes infected with yellow fever causative virus (hereinafter abbreviated as mosquitoes, or Hosts such as tsuetsue flies, or Miyairi-kai, or buoys, or medina filamentous worms) are malaria parasites, trypanosoma protozoa, sand flies protozoa, parasites, parasites, infected larvae, and Heartworm (hereinafter referred to, for short, the malaria parasite), and the like and can be coexistence. This is because mosquitoes acquire the autoimmune function in the host mosquito body by antigen-antibody reaction against malaria parasite. This means that all proteins, glycoproteins, sugar chains, lipids, and the like that make up the mosquito body and skeleton have elements that can become antigens of malaria. From the above, other than mosquitoes, for example, fly flies that are infected with Trypanosoma protozoa,
Or Miyairi shellfish infected with parasites, or flyfish infected with infected larvae, flies infected with infected larvae, or medina filamentous insects infected with filamentous worms As well as the mosquitoes infected with malaria parasites,
All the proteins, glycoproteins, sugar chains, lipids, etc. that are the bodies that make up the bodies of flies and filamentous worms, and the skeletons of the bodies are sleep disease, schistosomiasis, leishmania There will be elements that can be active ingredients such as antigens such as symptom, onchocerciasis, ocular complications, and filariasis, or similar antigens. This means that it is a vaccine raw material and a vaccine. In addition, mosquitoes infected with dengue-causing virus, mosquitoes infected with Japanese encephalitis virus, or mosquitoes infected with yellow fever virus are also described above. Similarly, all the proteins, glycoproteins, sugar chains, and lipids that make up the bodies of mosquitoes infected with dengue fever, Japanese encephalitis, and yellow fever, and the skeletons that make up the skeleton There will be an element whose disease name can be an active ingredient such as an antigen such as dengue fever, Japanese encephalitis and yellow fever, or a similar antigen. This means that it is a vaccine raw material and a vaccine.

(28) includes mosquitoes that transmit malaria parasites, dengue fever, Japanese encephalitis, mosquitoes that transmit viruses causing yellow fever, fly flies that mediate trypanosomiasis, sand turtles that transmit protozoa, or parasitism From freshwater shellfish such as Miyairi-kai which carry insects, or flyfish that carries infected larvae, or flies that also carry infected larvae, or medina filamentous insects that carry filamentous worms (hereinafter referred to as mosquitoes) When extracting an antigen or a pseudoantigen, the mosquito fine powder that has been dried and pulverized well is made alkaline with a PH concentration of alkaline powder, for example, PH
0.45μm PTFE after alkaline extraction of the active ingredient such as target antigen or pseudo antigen from the body of mosquito using alkaline aqueous solution with a concentration of 8.0 or higher, or ethanol aqueous solution with a PH concentration of 8.0 or higher An active ingredient filtered using a filter made of 0.45 μm or a filter made of 0.45 μm is used as a vaccine raw material or a vaccine by subcutaneous injection.

Furthermore, as shown in Table 22 below, the content (1) includes a female mosquito female (hereinafter abbreviated as a mosquito mosquito) in which the malaria parasite that causes malaria is infected in the salivary glands. A large amount of the mosquitoes that are infected with Plasmodium mosquitoes are dried in the state of the venom mosquitoes, and are then sterilized using autoclaving, X-rays, or gamma rays. For example, liquid nitrogen, or jet mill, or tentative name, ultra-low-temperature zet mill crushing method (hereinafter abbreviated) Grind using a grinding means such as a jet mill.
Or, using a wet high-pressure atomization machine manufactured and sold by Nanomizer Co., Ltd., located in 1-1-40 Suehirocho, Tsurumi-ku, Yokohama, HIV, HCV, HSV, HPV, poliovirus, or Viruses that cause other infectious diseases, or Mycobacterium tuberculosis, or cells of bacterial species that cause other infectious diseases, or malaria parasites, trypanosoma protozoa, spirochete parida, or other infectious disease protozoa For example, for the purpose of crushing to a fine powder of 30 nm or less, the wet high-pressure atomization machine (hereinafter abbreviated as Nanomizer), which uses the basic principle of a sterilization method with supercritical carbon dioxide, is used. Use two digits n
m can be pulverized and pulverized to 30 nm or less.
Using an ultra-low temperature jet mill pulverization method or an ultrasonic crushing machine (hereinafter abbreviated as nanomizer, jet mill, or ultrasonic crushing machine), the particle diameter is 50 μm or less,
(50 nm) or 0.03 μm (30 nm) or less, for the purpose of forming a tablet mainly composed of fine powder of anopheles mosquito, the composition as shown in Table 22 and fine powder of anopheles mosquito The fine powder of the spotted mosquito is mixed and tableted to form a plain tablet that is mainly composed of the fine powder of the spotted mosquito.

As the content (2), the peptides, proteins, sugar chains, and the like that are described in the above (1), which constitute the fine powder of an anopheles mosquito with a particle diameter of 50 μm or less by drying the anopheles mosquito, In addition, since the lipid is denatured by the influence of the secretory fluid which is the digestive fluid in the stomach, which is a digestive organ having a high acid value, Table 22 shows the purpose of avoiding the influence of the secretory fluid of the gastric juice. Thus, after forming an uncoated tablet mainly composed of fine powder of anopheles mosquito, the surface of the uncoated tablet is hybromellose phthalate (hereinafter abbreviated as HPMCP), etc. Enteric coating is processed into a tablet of enteric solvent by using a material for surface treatment for enteric coating.

As the content (3), the surface of the uncoated tablet mainly composed of the fine powder of mosquitoes infected with the malaria parasite, whose disease name is the cause of malaria, explained in (2) above. Top is HP
Tablets coated with enteric coating using MCP are administered orally, and peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that make up the mosquitoes are put into the intestinal tract. By ingesting into the body, the human body recognizes a minute fragment of the protein constituting the spotted mosquito as a human body and forms an antigen-antibody complex by recognizing it as an antigen, and an immune response is established.
As a result, the human body memorizes immunity against malaria, and the immune memory is established. As a result, there is an effect that the disease name becomes a treatment means for malaria at a very low cost.

As the content (4), as shown in Table 23 below, Trypanosoma protozoa whose disease name is the cause of sleep sickness proliferates a large amount of tsetse flies that are infecting salivary glands and are infected with Trypanosoma protozoa. The tsetse flies are dried as they are, and trypanosome protozoa, other protozoa, other viruses, and other germs at high temperature and high pressure using sterilization means such as autoclave, X-rays, or gamma rays. The tsetse fly after being sterilized in an aseptic state, for example, using a pulverizing means such as a jet mill, the particle diameter is 50
For the purpose of forming a tablet mainly composed of fine powder of tsetse fly, not more than μm or 0.03 μm (30 nm), the composition as shown in Table 23 and the fine powder of tsetse fly were used. The fine powder of tsetse fly is mixed and tableted to form an uncoated tablet, which is a tablet mainly composed of fine powder of tsetse fly.

The content (5) comprises the fine powder of the tsetse fly described in (4) above, wherein the tsetse fly is dried to a particle diameter of 50 μm or less, or 0.03 μm (30 nm) or less. Peptides, proteins, sugar chains, and lipids are denatured under the influence of the secretory fluid that is the digestive fluid in the stomach, which is a digestive organ with high acidity, so avoid the influence of this secretory fluid For the purpose, as shown in Table 23, after forming an uncoated tablet mainly composed of fine powder of tsetse fly, on the surface of the uncoated tablet, hybromellose phthalate (hereinafter referred to as “hybromellose phthalate”) Enteric coating is performed by using a material that performs surface processing for enteric coating processing such as HPMCP (abbreviated as HPMCP) to obtain an enteric solvent tablet.

As the content (6), the surface of the uncoated tablet mainly composed of tsetse fly powder infected with trypanosomiasis protozoa whose disease name is the cause of sleep disease explained in (5) above. Tablets that are enteric coated using HPMCP on the top are orally administered, and peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that make up tsetse flies By ingesting into the body, the human body recognizes minute fragments of proteins constituting tsetse flies and the human body recognizes it as an antigen to form an antigen-antibody complex, thereby establishing an immune response. Thereby, the human body memorizes immunity against sleeping sickness and the immune memory is established. As a result, there is an effect that the disease name becomes a therapeutic means for sleeping sickness at a very low cost.

As (7) of the contents, as shown in Table 24 below, the disease name is a striped mosquito infected with dengue fever (hereinafter abbreviated as dengue fever) virus (hereinafter abbreviated as mosquito) Mosquitoes that are infected with dengue fever and leave the mosquitoes that are infected with the dengue fever virus in their entirety, and sterilize them by autoclaving, X-rays, or gamma rays. Mosquitoes infected with dengue-causing virus using other means, other protozoa, other viruses, and other germs sterilized at high temperature and pressure in a sterile condition, such as nanomizer or jet Using a grinding means such as a mill, the particle diameter is 50 μm.
The composition as shown in Table 24 for the purpose of forming a tablet mainly composed of mosquito fine powder which is made into a fine powder as a whole or less, or 0.03 μm (30 nm) or less, The mosquito is finely powdered and mixed with mosquito fine powder, and compressed into tablets to form uncoated tablets that are mainly composed of fine powder of mosquitoes infected with dengue fever.

As the content (8), the mosquito infected with dengue fever described in the above content (7) is dried to have a particle diameter of 50 μm or less, and 0.03 μm (30 nm) or less. Peptides, proteins, sugar chains, and lipids that make up the fine powder of mosquitoes are denatured by the influence of secretions that are digestive fluids in the stomach, which are digestive organs with high acidity. For the purpose of avoiding the influence of the liquid, as shown in Table 24, after forming an uncoated tablet mainly composed of mosquito fine powder, the surface of the uncoated tablet was hybromellose. Phthalates (hereinafter abbreviated
Enteric coating is performed using a material that is surface-treated for enteric coating such as HPMCP.

As the content (9), an uncoated tablet composed mainly of the fine powder of mosquitoes infected with the dengue-causing virus whose disease name is the cause of dengue fever explained in (8) above. HP on the surface
Tablets processed with enteric coating using MCP are orally administered, and peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that make up mosquitoes are placed in the intestine. When ingested into the body, the human body recognizes minute fragments of proteins constituting mosquitoes as human antigens and forms antigen-antibody complexes, thereby establishing an immune response. As a result, the human body stores the immunity against dengue fever and the immune memory is established. As a result, there is an effect that the disease name becomes a means of treating dengue fever at a very low cost.

As the content (10), as shown in Table 25 below, a large amount of insects infected with the infected larvae whose disease name is the cause of onchocercosis (hereinafter abbreviated as onchocercosis) The seedlings that are infected with the infected larvae that cause onchocercosis are left as they are, and the seedlings that are infected with the infected larvae that cause onchocercosis are completely dried, and then autoclave, X-ray, Or insects that have been sterilized at high temperature and high pressure under high sterilization conditions, such as buoys infected with infected larvae using sterilization means such as gamma rays, other protozoa, other viruses, and other bacteria , Nanomizer, or pulverizing means such as liquid nitrogen or jet mill, the particle diameter is 50 μm or less, or 0.03 μm (30 n
m) For the purpose of forming tablets mainly composed of insect powder, which are the following, the composition as shown in Table 25, and powder of powder of insect fruit Are mixed and tableted to form an uncoated tablet in which insect powder is mainly composed of tablets.

As the content (11), the diameter of the particle diameter is 50 μm or less by drying the insect fly infected with the infected larva causing the onchocerciasis described in (10) above, or 0 0.0
Peptides, proteins, sugar chains, and lipids that make up the powder of insect shellfish that are 3 μm (30 nm) or less are affected by the secretion of the digestive juice in the stomach, which is a digestive organ with a high acidic value. In order to avoid the influence of the gastric juice secretion, as shown in Table 25, after forming an uncoated tablet mainly composed of fine powder of insects, The surface of this uncoated tablet is enteric-coated using a material for surface treatment for enteric coating such as hybromellose phthalate (hereinafter abbreviated as HPMCP). Use enteric solvent tablets.

As the content (12), an uncoated tablet composed mainly of fine powder of insect shellfish infected with an infected larva whose disease name is the cause of onchocercosis described in (11) above. Oral administration of enteric coated tablets using HPMCP on the surface of peptides, peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that constitute insects By ingesting the human body through the intestinal tract, the human body recognizes minute fragments of the proteins that make up the insect fly, and the human body recognizes it as an antigen to form an antigen-antibody complex, resulting in an immune response. Is established. Thereby, the human body memorizes immunity against onchocercosis and the immune memory is established. As a result, there is an effect that the disease name becomes a therapeutic means for onchocerciasis at a very low cost.

As the content (13), as shown in Table 26 below, small pupae infected with infected larvae whose disease name is the cause of ocular complications (hereinafter referred to as ocular complications) (Hereafter, abbreviated
Small pupae or pupae) are proliferated in large quantities and infected with infected larvae that cause ocular complications in the same state as small pupae infected with infected larvae that cause ocular complications Small pupae that are dried and infected with infected larvae using sterilization means such as autoclave, X-rays, or gamma rays, other protozoa, other viruses, and other germs Low temperature within the range where the peptides, proteins, sugar chains, and lipids constituting
For example, sterilize in aseptic condition at a temperature within 60 degrees C. Alternatively, a small candy after sterilization using other sterilization means is sterilized using, for example, a nanomizer, liquid nitrogen, or pulverization means such as a jet mill, and the particle diameter is 50 μm. Or 0.03μ
For the purpose of forming tablets mainly composed of fine powder of small wrinkles with a size of m (30 nm) or less, a composition as shown in Table 26 and a small powder of fine wrinkles made of fine powder The fine powder of the cocoon is mixed and tableted to form an uncoated tablet, which is a tablet mainly composed of small fine cocoon powder.

As the content (14), the small cocoon infected with the infected larva causing the eye complication described in (13) above is dried, and the particle diameter is 50 μm or less, or 0.03μm (
Peptides, proteins, sugar chains, and lipids that make up the fine powder of small spiders with a thickness of 30 nm or less are denatured by the influence of secretions, which are digestive fluids in the stomach, which are digestive organs with high acidity Therefore, for the purpose of avoiding the influence of the secretion of this gastric juice, as shown in Table 26, after forming an uncoated tablet mainly composed of fine powder of small sputum, this uncoated tablet On the surface of the tablet, enteric coating is performed using a material for surface treatment for enteric coating such as hybromellose phthalate (hereinafter abbreviated as HPMCP). Use tablets.

As the content (15), the main powder described in (14) of the above content is a small cocoon powder in which a small cocoon whose disease name is the cause of ocular complications is infected with an infected larva. Peptides, proteins, sugar chains, and lipids (hereinafter abbreviated to form small vagina) are administered orally by administering enteric-coated tablets using HPMCP onto the surface of the uncoated tablets as ingredients. The human body ingests the protein in the intestinal tract, and the human body recognizes the minute fragments of the protein that constitutes a small spider and the human body recognizes it as an antigen to form an antigen-antibody complex. As a result, an immune response is established. Thereby, the human body memorizes the immunity against the eye complication and the immune memory is established.
As a result, there is an effect that the disease name becomes a therapeutic means for ocular complications at a very low cost.

As (16) of the content, as shown in Table 27 below, a fly that is infected with an infected larva whose disease name is the cause of leishmaniasis (hereinafter referred to as leishmaniasis) is shown. The larvae that are infected with the infected larvae that cause leishmaniasis are dried, and the After sterilizing Stem fly, other protozoa, other viruses, and other bacteria that are infected with infected larvae by using sterilization means such as crepe, X-rays, or gamma rays, at high temperature and high pressure. For example, using a pulverizing means such as nanomizer, liquid nitrogen, or jet mill, the diameter of the particle size is 50 μm or less, or .03μm was (30 nm) or less, for the purpose of forming a tablet as a main mainly of fine powder of sandfly, the composition as shown in Table 27,
A fine powder of a sand fly is mixed with a fine powder of a fly fly and compressed to form an uncoated tablet which is a tablet mainly composed of the fine powder of a fly fly.

As the content (17), the sand flies infected with the infected larvae causing leishmaniasis described in the above content (16) are dried and the diameter of the particle diameter is 50 μm or less, or 0 A peptide constituting a fine powder of a fly fly, which is not more than 03 μm (30 nm),
Proteins, sugar chains, and lipids are denatured by the influence of secretions that are digestive fluids in the stomach, which are digestive organs with high acidity. 27, after forming an uncoated tablet mainly composed of fine powder of sand fly, the surface of the uncoated tablet was coated with hybromellose phthalate (hereinafter abbreviated as HPMCP). Enteric coating using a material for surface treatment for enteric coating, such as enteric coating, to obtain an enteric solvent tablet.

As the content (18), the fine powder of the fly fly whose disease name is the cause of leishmaniasis explained in the above content (17) and infected with the infected larvae is the main component. Peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as protein) that make up the sand flies are obtained by orally administering enteric-coated tablets using HPMCP on the surface of the uncoated tablets. When the human body ingests it in the intestinal tract, the human body recognizes a minute fragment of the protein that constitutes the fly fly, the human body recognizes it as an antigen, and forms an antigen-antibody complex, An immune response is established. Thereby, the human body memorizes the immunity against leishmaniasis and the immune memory is established. As a result, there is an effect that the disease name becomes a treatment means for leishmaniasis at a very low cost.

As the content (19), as shown in Table 28 below, the disease name is Chagas disease (hereinafter,
A large amount of turtles infected with the cruising Trypanosoma protozoa (hereinafter abbreviated as Trypanosoma protozoa), which is the cause of Chagas disease (abbreviated as Chagas disease), are infected with the Trypanosoma protozoa that is responsible for Chagas disease. The dry turtle infected with Trypanosoma protozoa causing Chagas disease in the same state is dried and infected with Trypanosoma protozoa using sterilization means such as autoclave, X-rays, or gamma rays. Low temperature, for example 60 degrees, within a range where the dehydrated sour turtle, sugar chain, and carbohydrate are not denatured
The turtle after being sterilized at a temperature within C is sterilized by using a crushing means such as nanomizer, liquid nitrogen, or jet mill, and the particle diameter is 50 μm or less, or 0.03 μm ( 30 nm) or less, for the purpose of forming a tablet composed mainly of fine powder of turtles, the composition shown in Table 28 and fine powder of turtles made of fine powder of turtles were mixed. The tablet is pressed to form a plain tablet in which the fine powder of sour turtle is the main component tablet.

As the content (20), the sand turtle infected with the Trypanosoma protozoa causing Chagas disease described in the above content (19) is dried to have a particle diameter of 50 μm or less, or 0.03 μm. Peptides, proteins, sugar chains, and lipids that make up the fine powder of turtles (30 nm) or less are denatured by the influence of the secretory fluid that is the digestive fluid in the stomach, which is a digestive organ with a high acidic value. Therefore, for the purpose of avoiding the influence of the secretion of this gastric juice, as shown in Table 28, after forming a plain tablet mainly composed of fine powder of turtle, this uncoated tablet Enteric coating using a material for surface treatment for enteric coating processing, such as hybromellose phthalate (hereinafter abbreviated as HPMCP), etc. To do.

As the content (21), the main component is the fine powder of the sea turtle explained in (20) of the above content, in which the turtle, whose disease name is the cause of Chagas disease, is infected with the protozoan of Cruz trypanosoma. Peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that make up the sour turtle after oral administration of enteric-coated tablets using HPMCP on the surface of uncoated tablets When the human body ingests into the body through the intestinal tract, the human body recognizes minute fragments of the protein that constitutes the turtle, and the human body recognizes it as an antigen to form an antigen-antibody complex, resulting in an immune response. To establish. Thereby, the human body memorizes immunity against Chagas disease, and the immune memory is established. As a result, there is an effect that the disease name becomes a treatment method for Chagas disease at a very low cost.

In addition, the disease names described above are non-toxic antigens for diseases such as malaria, sleep diseases, onchocerciasis, ocular complications, leishmaniasis, and Shagal disease (hereinafter abbreviated as malaria). In a manner similar to that used to form a vaccine (hereinafter abbreviated as a vaccine or antigen), the disease may be AIDS (HIV), influenza (IFV), dengue fever and herpes (H
The means for forming a vaccine that is a non-toxic antigen for diseases caused by viruses such as SV) is as follows for the diseases such as HIV, IFV, HSV, etc. in the following (1) to (14) Means will be described.

As (1), chimpanzees that are infected with the same HIV as humans, or chimpanzees (hereinafter abbreviated as chimpanzees) that are infected with HIV, are infected with HIV, and the blood of chimpanzees infected with HIV is dried. And the purpose of pulverizing the blood components of chimpanzee whole blood dried to a water content of 0.1% or less into fine powders having a diameter of 50 μm or less, or 0.03 μm (30 nm) or less, and whole blood Blood component or whole blood blood component excluding blood cells, and plasma component consisting of serum and fibrin (hereinafter abbreviated as plasma, blood, or whole blood component) For the purpose of sterilizing various miscellaneous bacteria, a blood stone or liquid nitrogen or a zet mill or a nanomizer (hereinafter abbreviated as nanomizer or zetmill) is used to make blood components of whole blood into a fine powder. Furthermore, after the blood component of whole blood or plasma component is made into fine powder
Sterilize various miscellaneous bacteria contained in blood components of whole blood using X-rays (X-rays), gamma rays, or other means without denaturing the minute fragments of the proteins that make up HIV. .

(2) As described in (1) above, the blood component of whole blood collected from chimpanzee or the plasma component is dried, and the main component tablet is obtained by drying the blood component of whole blood or the fine powder of plasma component. For the purpose of forming a blood component fine powder of blood components collected from a chimpanzee by mixing and compressing a composition as shown in Table 29 and a blood component of whole blood or a fine powder of plasma component Form an uncoated tablet which is a tablet of the main component. Peptides, proteins, and sugars that constitute blood components of whole blood collected from chimpanzees infected with HIV by orally administering tablets enteric-coated on the surface of the uncoated tablets using HPMCP When the human body ingests chains and lipids (hereinafter abbreviated as proteins) into the body through the intestinal tract, the human body constitutes blood components or plasma components of whole blood collected from chimpanzees infected with HIV The human body recognizes the minute cross-section of the protein protein as an antigen to form an antigen-antibody complex, and an immune response is established. Thereby, the human body memorizes immunity against AIDS, and the immune memory is established. as a result,
At a very low cost, the name of the disease is an effective treatment for AIDS.

(3) As described in the above (1) and (2), the blood component of whole blood collected from a chimpanzee, or the blood component or plasma component of whole blood obtained by drying the plasma component to obtain a fine powder In order to form water for injection from the fine powder of No. 1, dissolved in an aqueous solution or an aqueous ethanol solution, centrifuged, and the supernatant was filtered using a PTFE 0.03 nm filter or a PVCD 0.03 nm filter. An aqueous solution for ethanol for injection or an aqueous ethanol solution is administered intravenously or injected subcutaneously, so that the human body collects blood components of whole blood collected from chimpanzees infected with HIV, or proteins constituting plasma components. The human body recognizes a minute cross section as an antigen and forms an antigen-antibody complex, and an immune response is established. Thereby, the human body memorizes immunity against AIDS, and the immune memory is established. As a result, the disease name is effective for treating AIDS at a very low cost.

As for (4), instead of the blood components of whole blood collected from chimpanzee as explained in (1), (2) and (3) above, humans with HIV / AIDS patients are infected with HIV. When the blood component or plasma component of whole blood collected from a human body is used instead of the blood component or plasma component of whole blood collected from a chimpanzee, a vaccine that is an antibody against HIV is more easily obtained. Can be formed.

(5): Human or pig blood infected with IFV in chickens, pigs, or other mammals including humans (hereinafter abbreviated as pigs) that are infected with the same IFV that is infected with humans The blood component of human or pig infected with IFV, or the blood component of plasma or plasma, and the blood component of porcine whole blood dried to a water content of 0.1% or less. 0.0
For the purpose of pulverizing to a fine powder with a particle diameter of 3 nm or less and the purpose of sterilizing various miscellaneous bacteria contained in blood components or plasma components of whole blood, a stone mill, ball mill, zet mill, or nanomizer Or liquid nitrogen (hereinafter abbreviated as nanomizer or zet mill) to make the blood component of whole blood or plasma component fine powder. Furthermore, the blood component of the whole blood or the plasma component is contained in a means that does not denature the minute fragments of the protein constituting the FIV after the blood component or the plasma component of the Nanomizer whole blood is made into a fine powder. The various miscellaneous bacteria are sterilized using X-ray (X-ray) or other means.

(6) As described in (5) above, blood components of whole blood collected from humans or pigs,
Or the composition as shown in Table 30 and the blood components of whole blood for the purpose of drying the plasma components to form a tablet mainly composed of blood components of whole blood or fine powder of plasma components Alternatively, a plasma component is mixed with a fine powder and tableted to form an uncoated tablet in which a blood component collected from a human or a pig or a fine powder of a plasma component is a tablet containing a main component. Tablets enteric-coated using HPMCP on the surface of the uncoated tablets are orally administered to constitute blood components of whole blood collected from IFV-infected humans or pigs, or plasma components. The human body ingests the peptides, proteins, sugar chains, and lipids (hereinafter referred to as proteins for short) that are in the intestine,
The human body recognizes the minute blood protein of the blood component of whole blood collected from humans infected with IFV or pigs, or the plasma component, and recognizes it as an antigen to form an antigen-antibody complex. And an immune response is established. As a result, the human body remembers immunity against influenza with the disease name, and the immune memory is established. As a result, there is an effect that the disease name becomes a means of treating influenza at a very low cost.

(7) As described in the above (5) and (6), the blood component of whole blood collected from humans or pigs, or the blood component of whole blood obtained by drying the plasma component into a fine powder, Alternatively, for the purpose of forming water for injection from fine powder of plasma components, it is dissolved in an aqueous solution or an ethanol aqueous solution and centrifuged, and the supernatant is a PTFE 30 nm or less filter, or PTDF 30 n
The body of human blood collected from humans or pigs infected with IFV by intravenous administration or subcutaneous injection of an aqueous solution for ethanol for injection or an aqueous ethanol solution filtered using a filter of m or less The human body recognizes a minute fragment of a protein constituting a blood component or plasma component as an antigen to form an antigen-antibody complex, and an immune response is established. As a result, the human body remembers immunity against influenza with the disease name, and the immune memory is established. As a result, there is an effect that the disease name becomes a means of treating influenza at a very low cost. In addition, it is more convenient if blood of a human whose disease name is infected with influenza is collected, and a vaccine for the disease whose name is an antigen is formed using human blood to form a vaccine for influenza.

(8) As described in the above (5), (6) and (7), highly pathogenic avian influenza virus (H5N1 type) instead of whole blood blood component or plasma component collected from pigs When the blood components of whole blood collected from chickens infected with sera are used in place of the blood components of whole blood collected from pigs, a vaccine that is an antibody against highly pathogenic avian influenza virus (H5N1) Can be formed.

(9) As a pig infected with the same dengue fever virus that humans infect, or humans infected with dengue fever in other mammals including humans (hereinafter referred to as pigs), or pig blood, Or a human who has dried the plasma components and dried the water content to 0.1% or less,
Or the purpose of pulverizing the blood component or plasma component of porcine whole blood into fine powder with a particle size of 30 nm or less, and sterilizing various miscellaneous bacteria contained in the blood component or plasma component of whole blood For the purpose of doing this, a stone mortar or ball mill, or liquid nitrogen, or a nanomizer, or a zet mill (
Hereinafter, the blood component or plasma component of whole blood is made into a fine powder by using Nanomizer or Zetmill for short. Furthermore, the blood component of whole blood contains various blood components or plasma components in a way that does not denature the minute fragments of the protein that constitutes dengue fever after the whole blood component or plasma component is made into a fine powder. Various miscellaneous bacteria are sterilized using X-rays (X-rays), gamma rays or other means.

(10) As described in (9) above, blood components of whole blood collected from humans or pigs,
Or for the purpose of drying the plasma component to form a main component tablet with the blood component of whole blood, or a fine powder of plasma component, and the blood component of whole blood, or A plasma component is mixed with a fine powder and compressed to form a blood component collected from a human or a pig, or an uncoated tablet whose main component is a fine powder of a plasma component is a tablet. Blood component of whole blood collected from porcine infected by dengue fever by orally administering a tablet whose enteric coating is processed on the surface of the uncoated tablet using HPMCP, or peptide constituting plasma component , Proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) into the body through the intestinal tract, the human body is blood components of whole blood collected from humans or pigs infected with IFV Or a minute fragment of a protein that causes plasma components to be recognized as an antigen by the human body to form an antigen-antibody complex,
An immune response is established. Thereby, the human body memorizes the immunity against dengue fever and the immune memory is established. As a result, there is an effect that the disease name becomes a means of treating dengue fever at a very low cost.

(11) As described in (9) and (10) above, the blood component of whole blood collected from humans or pigs, or the blood component of whole blood obtained by drying the plasma component into a fine powder, Alternatively, for the purpose of forming water for injection from a fine powder of plasma components, it is dissolved in an aqueous solution or an ethanol aqueous solution and centrifuged, and the supernatant is filtered with a PTFE filter of 30 nm or less, or PVDF 3
Blood components of whole blood collected from pigs infected with dengue fever by intravenous administration or subcutaneous injection of an aqueous solution intended for water for injection filtered using a filter of 0 nm or less or an aqueous ethanol solution The human body recognizes a minute cross section of the protein constituting the protein as an antigen and forms an antigen-antibody complex, and an immune response is established. Thereby, the human body memorizes the immunity against dengue fever and the immune memory is established. As a result, there is an effect that the disease name becomes a means of treating dengue fever at a very low cost. In addition, it is more convenient if blood of a person whose disease name is infected with dengue fever is collected, and a vaccine with the name of the disease as the antigen is dengue fever using human blood.

(12): Herpes simplex that humans infect (hereinafter abbreviated as herpes or HSV)
The human blood or plasma component or mouse blood or plasma component infected with HSV in a mouse or ferret (hereinafter abbreviated as mouse) infected with the same HSV is dried to have a water content. The purpose of pulverizing the blood component or plasma component of human or mouse whole blood dried to 0.1% or less into a fine powder having a diameter of 50 μm or less, or 0.03 μm (30 nm), and whole blood Liquid nitrogen or stone mortar, or ball mill, or nanomizer, or zet mill (hereinafter abbreviated as nanomizer or zet mill) for the purpose of sterilizing various miscellaneous bacteria contained in blood components or plasma components Then, the blood component or plasma component of whole blood is made into a fine powder. Furthermore, the blood component of whole blood or the plasma component is contained in a means that does not denature the minute fragments of the protein constituting the HSV after the blood component or plasma component of the whole blood is made into a fine powder. Various miscellaneous bacteria are sterilized using X-rays (X-rays), gamma rays or other means.

(13) As described in (12) above, the blood component of whole blood or plasma component collected from a human or mouse is dried, and the blood component of whole blood or the fine powder of plasma component is used. For the purpose of forming a main component tablet, the composition as shown in Table 32 was mixed with a blood component of whole blood or a fine powder of a plasma component, tableted, and blood was collected from a human or a mouse. An uncoated tablet in which a fine powder of blood component or plasma component is a main component is formed. Blood component of whole blood collected from mice infected with HSV by orally administering a tablet whose enteric coating is processed on the surface of the uncoated tablet using HPMCP, or a peptide constituting the plasma component , Proteins, sugar chains, and lipids
(Hereafter, abbreviated as protein), the human body ingests the body through the intestine,
The blood component of whole blood collected from a mouse infected with V, or a minute fragment of the protein constituting the plasma component, is recognized by the human body as an antigen to form an antigen-antibody complex, resulting in an immune response. Is established. Thereby, the human body memorizes the immunity against the HSV fever, and the immune memory is established. As a result, there is an effect that the disease name becomes a treatment means for HSV at a very low cost.

(14) As described in the above (12) and (13), the blood component of whole blood collected from a human or a mouse, or the blood component of whole blood obtained by drying the plasma component into a fine powder, or For the purpose of forming water for injection from fine powder of plasma components, dissolve in aqueous solution, ethanol, human, or aqueous ethanol solution, centrifuge and supernatant with PTFE filter of 30 nm or less, or 30 nm or less The human body is a blood component of whole blood collected from a human or mouse infected with HSV by intravenous administration or subcutaneous injection of an aqueous solution intended for water for injection filtered with a PVDF filter, or an ethanol aqueous solution, or A minute fragment of the protein that constitutes HSV contained in peptides, proteins, sugar chains, and lipids (hereinafter abbreviated as proteins) that constitute plasma components. Recognizes the antigen will form a antigen-antibody complex, an immune response is established. Thereby, the human body memorizes the immunity against the HSV fever, and the immune memory is established. As a result, the disease name is effective for treating herpes at a very low cost. In addition, it is more convenient if blood of a human whose disease name is infected with herpes is collected and a vaccine for herpes whose name is an antigen is formed using human blood or plasma components.

In addition, the disease names described above are non-toxic to diseases such as malaria, sleep disease, Nagana disease, onchocercosis, ocular complications, leishmaniasis, and Chagas disease (hereinafter abbreviated as malaria). As a means for forming a vaccine that is a sex antigen (hereinafter referred to as vaccine or antigen for short), a vaccine that is an antigen in the same manner as described in the above (1) to (14) A vaccine can be easily formed.

In addition, for the diseases described above, such as malaria, sleep disease, Nagana disease, onchocerciasis, ocular complications, leishmaniasis, and Chagas disease (hereinafter abbreviated as malaria). As a means for forming a vaccine that is a non-toxic antigen, it will be described below that a vaccine can be easily formed as described above.

As for (1), when the disease name is malaria, mammals such as pigs, cattle, horses, monkeys, and Chinhanji (hereinafter abbreviated as monkeys or cattle) including humans are infected with malaria parasites. Therefore, when blood is collected from a monkey infected with Plasmodium, the blood component of whole blood collected from the monkey or the plasma component contains an antigen whose disease name is a vaccine for malaria or sleeping sickness. Contains. By using blood components of whole blood collected from monkeys or cattle, a vaccine whose antigen is an antigen of malaria can be easily formed. It is more convenient if blood of a human whose disease name is infected with malaria is collected and used to form a vaccine whose antigen is a malaria antigen.

As for (2), the disease names are sleeping sickness, nagana disease, onchocercosis, ocular complications, leishmaniasis, and Shagal's disease, and syphilis (hereinafter abbreviated as sleeping sickness) are swine, cattle, and humans. ,
Mammals such as horses, monkeys, and chimpanzees (hereinafter abbreviated as monkeys or cattle) are infected with Trypanosoma protozoa, so when blood is collected from a cow infected with Trypanosoma protozoa, The blood component of the collected whole blood or the plasma component contains an antigen whose disease name is malaria or sleep vaccine. By using blood components or plasma components of whole blood collected from monkeys or cattle, a vaccine whose disease name is an antigen of sleeping sickness can be easily formed. It is more convenient to collect and use the blood of a human whose disease name is malaria or sleep disease to form a vaccine whose disease name is an antigen of sleep disease.

Title “R & D to form vaccines using blood from AIDS patients”

Objective To form a vaccine that is 100% non-toxic antigen using the blood component of whole blood or plasma component of AIDS patients whose human being is infected with HIV.

(2) There are about 30,000 or more kinds of miscellaneous miscellaneous things currently found on the earth in the blood component of the whole blood collected from the human body or plasma component explained in (1) above. Among the various viruses
The smallest virus is a parvovirus whose disease name is the causative virus of apple disease, and the parvovirus size is 30 nm. The second smallest virus is the causative virus of hepatitis C (HCV) at 50 nm. The size of HIV whose disease name is the virus causing AIDS is 120 nm.

(3) 100% miscellaneous viruses, bacteria and malaria at the present time using blood components or plasma components of whole blood collected from the human body, as explained in (1) and (2) above To form a vaccine that is 100% infectious, non-toxic and irritating antigen against protozoa such as protozoa, using whole blood or plasma components collected from the human body ,Current,
Since the size of the parvovirus that has been found on the earth is 30 nm, blood components of whole blood collected from the human body, or red blood cells, white blood cells, platelets, various miscellaneous viruses, If the size of miscellaneous bacteria and various miscellaneous protozoa (hereinafter referred to as bacteria for short) can be shattered to a parvovirus size of 30 nm or less,
A completely harmless vaccine can be formed against infectious diseases including apple disease.

(4) The virus whose cause is the apple disease described in (1), (2) and (3) above is
Because it is a parvovirus, the size of the parvovirus is 30nm.
As a means that can be pulverized to a smaller size of 30 nm or less, the blood component of whole blood collected from the human body or the plasma component is frozen in a room of, for example, about −10 degrees C. Or after pulverizing the plasma component to a size of about several mm in diameter,
When pulverized using a mortar, stone mill, ball mill, nanomizer, and zet mill (hereinafter abbreviated as nanomizer or zet mill) in a room at around 50 degrees C, the size of the barbovirus is reduced to 30 nm or less. I found that it can be crushed.

(5) Repeating the same work process several times after freezing the blood component or the plasma component of whole blood collected from the human body described in (4) above, for example, in a room of around −50 ° C. Nanomizer, or the same process as processing to fine powder using a Zet mill, Nanomizer,
Or if it repeats using a zet mill, the blood component of whole blood can be made still smaller to the limit.

(6) When freezing blood components of whole blood collected from a human body containing protozoa such as viruses, bacteria, and malaria parasites as described above, if the blood components are frozen very slowly, Since the volume of the virus, bacteria, and protozoa contained in the volume of the virus, bacteria, and protozoa is increased, the volume of the virus, bacteria, and protozoa is increased. Slow freezing at the front and back temperatures is the most efficient pulverization.

Examples of the object described above will be described in the following (1) to (3).

As (1), human blood is collected from an AIDS patient infected with HIV, the blood component of whole blood collected from the human body, or the plasma component is frozen and pulverized using a zet mill, HIV, virus, bacteria, and protozoa containing blood components of whole blood or plasma components of AIDS patients dried to a water content of 0.1% or less, for example, 120 n which is the diameter of HIV
The purpose of pulverizing HIV containing the blood component or plasma component of whole blood of AIDS patients into a fine powder having a diameter of 30 nm or less, and the blood component or plasma component of whole blood For the purpose of crushing and sterilizing HIV or other viruses, bacteria, and protozoa contained therein, for example, the envelope that is the epidermis of nucleic acids in the case of HIV, a mortar, stone mill, ball mill,
Nanomizer and zet mill (hereinafter abbreviated as nanomizer or zet mill)
Can be ground into a fine powder having a diameter of 30 nm or less. Furthermore, the blood component or plasma component of whole blood is contained in a means that does not denature the minute fragments of the protein that constitutes HIV after the blood component or plasma component of whole blood is made into a fine powder. HIV or other viruses, bacteria and protozoa are sterilized by X-rays, gamma rays or other means.

(2) As described in (1) above, the blood components of whole blood containing HIV,
Alternatively, for the purpose of pulverizing the plasma component to form a tablet composed mainly of fine powder having a diameter of 30 nm or less, the composition shown in Table 33 and the blood component of whole blood or plasma component The fine powder is mixed and tableted to form an uncoated tablet that is a prototype of a blood component collected from a human body or a fine powder of a plasma component as a main component. Peptides, proteins, sugar chains, or blood components of whole blood collected from AIDS patients, or tablets that have been enteric coated on the surface of this uncoated tablet such as HPMCP. And lipid (hereinafter, abbreviated as protein) in the human intestinal tract, the human body collects blood components or plasma components of whole blood containing HIV collected from AIDS patients. The human body recognizes a minute fragment of the constituting protein as an antigen and forms an antigen-antibody complex. Thereby, the human body memorizes immunity against AIDS and forms an immune memory. as a result. The name of the disease is an effective treatment for AIDS at a very low cost.

The blood component or plasma component of whole blood containing HIV collected from an AIDS patient explained in (1) above is pulverized, and a fine powder having a diameter of 30 nm or less is dissolved in an aqueous ethanol solution. , Centrifuge and remove the supernatant from PTFE 30 nm or less filter or P
Filter using a 30 nm or less filter made by VDV to form water for injection. By intravenously or subcutaneously injecting this water for injection, the human body recognizes a minute protein fragment of HIV and the human body recognizes it as an antigen to form an antigen-antibody complex. Thereby, the human body memorizes immunity against AIDS and forms an immune memory. By this. The name of the disease is an effective treatment for AIDS at a very low cost.

The virus described in the above (1), (2), and (3) is intended to form a virus such as DNA and RNA that are nucleic acids, or a vaccine that is an antigen of HIV. The implementation plan is explained below.

The implementation plan starts in the first year and ends in the third year.

Implementation plan Ends from the first year to the second year.

(1) Blood is collected from a human who is infected with HIV and whose disease name is AIDS.

(2) Blood collected from a human AIDS patient or frozen from HIV-infected blood or plasma components.

(3) After freezing blood or plasma components infected with human HIV, physically using a mortar, stone mortar, ball mill, nanomizer, and zet mill (hereinafter abbreviated as nanomizer or zet mill) To a fine powder having a diameter of 30 nm or less.

(4) The blood component of whole blood or plasma component containing HIV described in (3) above is pulverized to form a tablet composed mainly of fine powder having a diameter of 30 nm or less. For the purpose, the composition as shown in Table 33 and the blood component of the whole blood or the fine powder of the plasma component are mixed and tableted, and the blood component or the fine component of the plasma component collected from the human body is compressed. An uncoated tablet is formed which is an original form of a tablet mainly composed of powder.

(5) The enteric coating process such as HPMCP is performed on the surface of the uncoated tablet, which is the prototype of the blood component collected from the human body or the fine powder of the plasma component as the main component, as described in (4) above. Into tablets.

(6) The tablet described in (5) above is taken by Midrisal or chimpanzee (hereinafter abbreviated as Midrisal) not infected with HIV, and Midrisal is an antigen antibody against HIV If it is confirmed whether or not the complex is produced in the body of Midrisal, and if the antigen-antibody complex is formed in the body of Midrisal, Midrisal has memorized immunity against AIDS.

(7) The blood component or plasma component of whole blood containing HIV collected from an AIDS patient as explained in (6) above is crushed, and a fine powder having a diameter of 30 nm or less is dissolved in an aqueous solution, or It is dissolved in an ethanol aqueous solution and centrifuged, and the supernatant is filtered using a PTFE 30 nm or less filter or a PVDV 30 nm or less filter to form water for injection. When this water for injection is administered intravenously or subcutaneously, the human body recognizes a minute protein fragment of HIV and the human body recognizes it as an antigen to form an antigen antibody. As a result, the human body memorizes immunity against AIDS and forms an immune memory.

Similar to the means described above, the means described below, the blood component of whole blood containing HIV, or the plasma component, or the size of the parvovirus is 30 nm or less, You may grind into pieces.

(1) A blood component or plasma component of whole blood containing HIV collected from a human body is slowly frozen at a temperature of around −10 degrees C. -1
When HIV is dehydrated in 96 ° C liquid nitrogen, cell nucleic acids and epidermis are broken apart.

The blood component of whole blood containing HIV collected from the human body as described in (2) above,
Alternatively, plasma components can be efficiently pulverized by placing them in liquid nitrogen at −196 ° C., dehydrating HIV and the like, and then finely pulverizing them again with a jet mill.

The advantage described above in (1) and (2) that the blood component of whole blood containing HIV or the plasma component is added to the interior of liquid nitrogen at −196 ° C. to make a fine powder is From small parvovirus to malaria parasite cells, there is an advantage that can be completely destroyed.

(1) The blood component or plasma component of whole blood containing HIV, as explained above,
After freezing very slowly at a temperature of around 10 degrees C to expand the moisture inside the cells, HIV
When the blood component or plasma component of whole blood containing selenium is -30 degrees C to -50 degrees C in a room with a diameter of several millimeters to several centimeters and pulverized with a jet mill at the same room temperature It was discovered that even a parvovirus having a particle size as small as 30 nm can be pulverized by the ultra-low temperature zet mill.

(2) In the ultra-low temperature zet mill described in (1) above, when the moisture is frozen and heavy, even a virus with a particle size as small as 30 nm can be pulverized. 100 nm is the limit. Freeze and increase the weight of the substance,
For example, it may be soaked in liquid nitrogen at −196 ° C. to reduce the bonding force between atoms for deterioration and pulverization. Therefore, the blood component or plasma component of whole blood containing HIV is -10 degrees C
To -50 degrees C in a room with a diameter of several millimeters to several centimeters, and pulverizing with a jet mill, even a virus with a small particle diameter of 30 nm is 10 nm with the ultra-low temperature jet mill.
It can be crushed into the following.

(3) In the ultra-low temperature zet mill described in (1) and (2) above, when blood components containing water containing HIV etc. are frozen very slowly at a temperature of around −10 ° C. ,
When the diameter becomes a particle diameter of several mm to several cm, and pulverization is performed at a room temperature of around −10 ° C. with a zet mill, even a virus having a particle diameter as small as 30 nm can be pulverized. This low temperature zet mill can grind viruses with a particle size of 10 nm.

(4) In the ultra-low temperature zet mill described in (1), (2) and (3) above, in order to increase the weight of the substance, after mixing with an aqueous solution and freezing, When the bonding force between them is lowered and pulverized again with an ultra-low temperature jet mill, the powder can be further refined.

(5) The ultra-low temperature zet mill described in (1), (2), (3) and (4) above includes electronic parts such as lithium ion batteries, cosmetics and pharmaceutical materials as other application fields. .
For example, in a room of −10 ° C. to −50 ° C., after the particle diameter of several millimeters to several centimeters is pulverized with this ultra-low temperature jet mill, even with a material having a small particle diameter of 30 nm, It can be pulverized to 10 nm or less.

(6) Since the ultra-low temperature zet mill described above does not heat, the virus is not denatured, and thus a harmless vaccine can be provided at a very low cost. Thereby, it becomes a temporary name and the ultra-low temperature jet mill grinding method characterized by being able to solve medical, energy, and environmental problems.

  The title is “Research and development of treatments that delay the onset of AIDS patients and prolong their lives”

AIDS virus (HIV) is dissolved and floating in the blood of AIDS patients whose target disease is infected with AIDS. The aim is to delay the onset of AIDS patients with the name of the disease by inactivating the AIDS virus, which is dissolved and floating in the blood, using Green Tea fine powder to inactivate the AIDS virus. In addition, as a treatment method for AIDS patients, a treatment method for AIDS patients with the least cost and few side effects is provided.

Content
By explaining the effects of catechins contained in Green Tea against AIDS virus that has been dissolved and suspended in the blood and malaria parasites, similar to the AIDS virus described above. Like influenza virus and malaria parasite,
The following (1), (2), (3), and (4) explain that it is possible to infer that the AIDS virus that has been dissolved and suspended in blood can be inactivated.

(1) As catechin, polyphenone 70S (70S) or sunphenone BG-3
As shown in the experimental results of mice infected with influenza virus using (BG-3) in FIGS. 4 and 5, catechin 70S significantly suppresses weight loss due to infection.
Moreover, it was judged that catechin BG-3 extended the survival days. For this reason, the experimental results that could be judged to show anti-influenza virus activity for both catechin 70S and BG-3 are shown in FIG. 4 and FIG.

(2) As for the anti-malarial activity using polyphenone 70S or BG-3 which is catechin
As shown in FIG. 1 and FIG. 2 in vitro experimental results, antimalarial activity was observed for both catechins polyphenone 70S and BG-3, and the experimental results are shown in FIG. 1 and FIG.

(3) As described in the above (1) and (2), the catechin contained in the fine powder of Green Tea is effective against anti-influenza virus activity against influenza virus or malaria parasite. It has been found that it has antimalarial activity.
However, the catechin has the following (1), (2), and (3).

As (1), since catechin has no action effect even if it is administered orally, it has been found that there is no action effect other than intraperitoneal administration or intravenous administration. This is because catechin easily undergoes a condensation reaction with proteins, saccharides, lipids and the like.

As (2), catechins need to be enteric-coated tablets with enteric coating in order to form tablets for oral administration.

As for (3), catechins are expensive for citizens of 36 South African countries in the sub-Saharan Desert, the region with the most AIDS patients in the world.
・ As for (4), the means for avoiding the disadvantages of catechins explained in (1), (2) and (3) above are the diameters of Green Tea fine powder as shown in Table 17. Green below 50μm
T
Form an uncoated tablet with ea fine powder as the main component, and use enteric coating material such as HPMCP on the surface of the uncoated tablet, and use it as an intestinal solvent. Inside, Green Tea
In the process of degrading Green Tea fine powder ingested in human blood by the kidneys and liver by the condensation reaction with iron (Fe), an inorganic substance of catechin, ,
Alternatively, it is intended to delay the onset of AIDS patients infected with AIDS virus by inactivating in the blood the AIDS virus that has been dissolved and suspended in the blood using the antioxidant action of catechin. The name of the disease will be used as a treatment for AIDS.

Characteristics of fecal carrots containing artemisinin, the title of the treatment for malaria

Artemisinin, the only remedy for malaria, is a substance contained in fecal carrots. Areas where malaria-causing mosquitoes breed, for example, artemisinin, which contains dung carrots cultivated in southern China, are located in areas where there is no malaria-causing mosquitoes, such as feces grown in Japan. The question remains why it is 14 times higher than the content of artemisinin in carrots.

As the purpose (1), there are two kinds of perennials of the asteraceae family, the scientific name is tile carrot and the scientific name is dung carrot. The scientific name of the carp that human beings eat and mix with edible mushrooms is called “carrot carrot”. Currently, it is fecal carrot that contains artemisinin, which is a raw material of the only specific medicine of the disease name malaria (hereinafter, abbreviated as malaria). This fecal carrot has been used as an antipyretic in the history of Chinese medicine in 4,000 years, reducing the high body temperature of the human body. Hydrophobic artemisinin was extracted from fecal carrots using an organic solvent, and this hydrophobic artemisinin was made hydrophilic by chemically bonding an OH group to it. Artesunate. Artemisinin contained in fecal carrots is contained in fecal carrots cultivated in regions where malaria is bred such as Guilin region in China or Yunnan region (hereinafter referred to as Guilin region) About 90% of fecal carrots, the raw material for artemisinin, the only specific medicine for which the disease name is malaria, which is currently used as a treatment for malaria on the earth. The production area is feces carrots grown in Guilin, China.
For the purpose of elucidating the question of why dung carrots cultivated in Guilin region have a high content of artemisinin, obtain exactly the same seeds as dung carrot seeds cultivated in Guilin region, Weather conditions such as temperature and humidity, which are external conditions in Japan where the disease name malaria is not breeding at all, using the same seeds of feces carrots grown in this Guilin region The same seed as the dung carrot seeds grown in the Guilin district in the greenhouse owned by Naruto University of Education, with hot and humid weather conditions similar to those of the Yunnan or Guilin districts of China , Even if cultivated feces carrots inside the greenhouse owned by the university,
Artemisinin contained in fecal carrots grown in a university in Naruto City, Japan, where no disease name is malaria, where the content of artemisinin contained in fecal carrots grown in Guilin is 1 Only fecal carrots containing only 14% artemisinin content can be cultivated. The purpose of research and development aimed at elucidating this question is (1).

As the purpose (2), for example, as a joint research facility with a university located in the Guilin region where the disease name is breeding malaria, there is no mosquito which causes the disease to transmit malaria.
The mosquito mosquito whose disease name mediates malaria is a structure with a structure that cannot enter the room, the roof is made of glass, the outer wall of the building has a mesh structure, good ventilation, It is a conventional cultivated land with a dung carrot grown inside the room of this structure after constructing a structure with a structure that cannot penetrate the room at all (the disease name is mediated by malaria The purpose of the research and development is to compare the content of artemisinin contained in dung carrots cultivated in the field).

In addition, the disease names described above are non-toxic to diseases such as malaria, sleeping sickness, Nagana disease, onchocercosis, ocular complications, leishmaniasis, and Shagal disease (hereinafter abbreviated as malaria). As a means for forming a vaccine that is a sex antigen (hereinafter abbreviated as a vaccine or antigen), it is an antigen in the same manner as described in the above (1) to (14). When a vaccine is formed, it can be easily formed.

Furthermore, the means for forming a vaccine intended for HIV will be described below.
The title "HIV is made into a vaccine by crushing nucleic acid and epidermis to 30nm or less"

The target disease name is 100% safe against AIDS, and can be formed at a very low cost, and the purpose is to form a tablet that can be a vaccine that is easy to take, or a vaccine for water for injection. We have invented and discovered the technology necessary to achieve this goal.

It has been about 30 years since the name of the background disease was discovered by AIDS patients. However, the current situation is that no effective vaccine has been developed. The development of vaccines using blood from AIDS patients infected with HIV is a theme that many researchers have worked on in the past. However, it was unsuccessful because the development of a technology for completely crushing HIV contained in AIDS patients could not be invented or discovered.

The blood components collected from patients with the disease name AIDS contain red blood cells, white blood cells, platelets, bacteria, HIV, and viruses such as parvovirus with a very small diameter of 30 nm (hereinafter abbreviated as HIV). Contain blood from an AIDS patient infected with HIV, and slowly freeze the blood collected from this AIDS patient at a temperature of about −10 ° C.
Cells containing HIV are expanded to make blood containing HIV a mass of ice, and further, a solid-state blood made of blood containing HIV a mass of ice is a liquid of −196 degrees c. The ice block with a diameter of around several millimeters is a jet mill or ball mill (hereinafter abbreviated to be a ball mill). Using a ball mill to crush blood containing HIV together with hard ice, a vaccine whose disease name is 100% safe against AIDS,
It will be described in the order of (1) to (12) below that it can be easily formed at a very low cost.

    (1) Collect blood infected with HIV from AIDS patients.

(2) The collected blood is frozen very slowly at a temperature of about −10 ° C. to expand the water inside the cells and freeze the blood containing HIV.

(3) The blood containing HIV is frozen, and the frozen blood is crushed into ice blocks having a diameter of several millimeters.

(4) A frozen blood clot that contains crushed HIV and frozen to a diameter of several millimeters is immersed in liquid nitrogen at 196 degrees c below freezing.

(5) A frozen structure with a diameter of around a few millimeters soaked in liquid nitrogen is placed inside a refrigerator with a freezing point of around -30 degrees c. Thousands of ceramic balls are put and rotated to grind. The name is HI using a ball mill
Freeze blood containing V and crush the frozen blood with hard ice using hard ice as a medium. Alternatively, pulverization is performed using both a ball mill and an ultra-low temperature jet mill.

(6) Blood containing HIV crushed using a ball mill is pulverized with ice, and the blood is returned to room temperature. The frozen blood is returned to a liquid state, and then a centrifuge. To separate the supernatant and collect the supernatant.

(7) Blood containing HIV is pulverized with hard ice using hard ice as a medium, and the supernatant separated using a centrifuge is frozen again and immersed in liquid nitrogen. After pulverization using a ball mill, for example, when filtration is performed using HemoFeel SH manufactured and sold by Toray Medical Co., Ltd., the hole diameter formed in the hollow fiber of HemoFeel SH is 70 mm (7 nm ), The molecular weight is 20,0 as shown in Table 34.
Until 00, the pore size, which is a pore size, passes even 70 mm, so AIDS virus HIV-
It is a capsid protein cocoon that constitutes one core, and from its precursor Gagp55 to HIV
HIV-1 Gagp24 produced by cleavage by -1 protease has a molecular weight of 24,
Therefore, even with a hole diameter of 70 mm pore size formed in a hollow fiber made of a PММA membrane shown in Table 34, the pore size can be recovered by passing about 60%.

(8) As shown in Table 34, when the pore size formed in the hollow fiber made of the PММA membrane is 100 mm, the molecular weight passes up to 50,000.
It can be said that it is the most suitable filter as a filter for filtering and collecting 1Gagp24.

(9) Further, as shown in Table 34, the explanation was made in the above (7) and (8).
For example, 70 mm (7 nm) and 100 mm (1 nm) formed on hollow fibers made of PM
Polymer membranes other than 0 nm) are 200 mm (20 nm) polymer formed on a hollow fiber made of PA membrane or PS membrane used as a filter for filtering for the purpose of fractionating plasma components. By using the membrane as a filter, even if a virus such as HIV is mixed, it can be completely removed.

(10) Dry the supernatant containing HIV fragments using freeze drying.

(11) Heat-sterilize or gamma-ray sterilize the fine powder containing the HIV fragment from which the supernatant has been dried at a temperature that does not denature the protein koji.

(12) An HIV-1 antibody that can be used as an antigen for a fine powder containing HIV-1 Gagp24, which is a fragment of HIV, obtained by pulverizing HIV-containing blood to 30 nm or less by the above processing means As a raw material for tablets as shown in Table 33, or as a raw material for water for injection, such as intravenous administration or subcutaneous injection.

In addition, as a means of pulverizing HIV, Poliovirus (PV), IFV, malaria parasite, or trypanosoma protozoa (hereinafter abbreviated as HIV or malaria parasite) into a fine powder, HIV or malaria parasite A blood component of whole blood contained in an infected animal or human body, or a plasma component obtained by separating a blood component of whole blood into a blood cell component and a plasma component using a centrifuge, A fine powder of plasma components obtained by separating blood components of whole blood into blood cell components and plasma components using a centrifuge using a millstone, ball mill, and jet mill (hereinafter abbreviated as jet mill). After being pulverized, it is formed into a hollow fiber made of a polymer membrane, such as a cuprophane membrane, a Pan membrane, a PMMA membrane, a glomerular membrane, a PA membrane, a PS membrane, and a peritoneum. Doing Membrane pore size is, for example, 30Å (3nm), 40Å (4nm),
Used as a hollow fiber for artificial dialysis using a hollow fiber having a pore size of 70 mm (7 nm), 100 mm (10 nm), 200 mm (20 nm), or other pore sizes, or a hollow fiber for plasma fractionation Fine particles of particle size mixed in the supernatant after centrifuge the blood component mixed with fine powder pulverized with HIV using an artificial dialysis analyzer For example, as a filter intended to be separated by filtering to a particle size of fine particles of 30 nm or less, a high pore having a pore size formed in a hollow fiber made of a polymer membrane is formed. Using hollow fibers made of molecular membranes, for example, as shown in Table 34, the molecular weight is 2
HIV-1 Gag p2 having a molecular weight of 66,000 using a filter having a pore size of 100 mm, which is a pore size made of a PMMA membrane capable of passing a molecular weight of 10,000
4 or a pore size of 100, which is a pore size made of a glomerular membrane capable of passing a molecular weight of 50,000, as also shown in Table 34.
A filtration method for forming an HIV vaccine for the purpose of filtering HIV-1Gag p24 having a molecular weight of 24,000 using a sputum filter.

Furthermore, after crushing the blood components of whole blood containing HIV, it is made of a polymer film,
For example, the membrane pore diameter formed in a hollow fiber made of a polymer membrane such as a Cuprophane membrane, a Pan membrane, a PMMA membrane, a glomerular membrane, a PA membrane, a PS membrane, and a peritoneum is, for example, 30 mm (3 nm), 40mm (4nm)
70 mm (7 nm), 100 mm (10 nm), 200 mm (20 nm), or other hollow fiber for artificial dialysis using a hollow fiber having a pore size that is a pore size, or a hollow fiber for plasma fractionation Purpose of use. Using an analyzer for artificial dialysis, fine particles of the particle size mixed in the supernatant after crushing the blood components of whole blood containing HIV and applying a centrifuge,
For example, as a filter for the purpose of filtering and separating fine particles with a particle size of 30 nm or less, a polymer membrane having a pore size membrane pore size formed on a hollow fiber made of a polymer membrane For example, for the purpose of gradual filtration, the filter is first filtered using a 200 大 き い large pore size filter and the second using a 100 ポ pore size filter. If the filter is filtered and then filtered using a filter with a smaller pore size and then filtered using a filter with a very small pore size of 70 mm, the particle size is large. A filtration method for the purpose of forming an HIV vaccine for the purpose of completely preventing excessive contamination of viruses such as HIV.

In addition, the name of the disease causes HIV, which is the causative virus of AIDS patients, or the virus that causes other infections, such as HCV, HSV, IFV, HPV, or the virus that causes infections such as Mycobacterium tuberculosis For the purpose of crushing seed cells or protozoa causing infectious diseases such as Plasmodium, Trypanosoma, and Spirocheta paridae (hereinafter abbreviated as HIV) into fine powders of 10 nm or less, for example. Blood component of whole blood or blood component which was dried using freeze-drying and then crushed into fine powder of 10 nm or less using a jet mill and blood was collected from a patient with AIDS To provide a vaccine that can protect against HIV in a very short time and at a very low cost, which can be a 100% safe antigen. It is characterized by the formation of an antigen-antibody complex, in which the disease name in the human body establishes immune memory against AIDS, and the human body acquires autoimmunity to cause the disease name to prevent AIDS. A method for preventing and treating AIDS as a disease name is a solution.

Furthermore, the names of the diseases are malaria, childhood paralysis, tuberculosis, sleeping sickness, nagana disease, leishmaniasis, chagas disease, schistosomiasis, onchocercosis, ocular complications, medinaminosis, dengue fever, AIDS, and yellow fever (hereinafter abbreviated) Thus, a therapeutic means for the human body to acquire autoimmunity against symptoms such as malaria or HIV) is provided.

As described above, as a solution, HIV whose disease name is the causative virus of AIDS patients
Or other infectious disease-causing viruses such as HCV, HSV, IFV, HPV, poliovirus, or other infectious disease-causing viruses, or cells of bacterial species that cause infectious diseases such as Mycobacterium tuberculosis,
Alternatively, for the purpose of crushing protozoa causing infectious diseases such as malaria parasites, trypanosoma protozoa, spirochete parida parasites (hereinafter abbreviated as HIV) into fine powders of 10 nm or less, for example, supercritical dioxide Using a wet high-pressure pulverization machine or an ultrasonic crushing machine (hereinafter abbreviated as nanomizer or ultrasonic crushing machine) using the basic principle of carbon sterilization method, the name of the disease is an AIDS patient, and HIV Blood component containing whole blood, or blood component of whole blood excluding blood cells, plasma component consisting of serum and fibrin, or culture medium cultivating HIV, or poliovirus, or other Virus, or tuberculosis or other bacterial species cells, malaria parasite, trypanosoma protozoa, or other protozoan microorganism, or animal or plant tissue Culture solution (hereinafter abbreviated as plasma component or whole blood component or culture solution) is crushed into fine powder of 10 nm or less, for example, and the disease name is AIDS Using a blood component of whole blood collected from a patient or a plasma component, or a culture medium in which HIV is cultured, an antigen that can be a 100% safe antibody is protected in a very short time and at a very low cost. Create a target, 100% safe antigen, form an antigen-antibody complex against HIV in the human body, establish immune memory against AIDS in the human body, and autoimmune the human body A method for preventing and treating AIDS with a disease name characterized in that the disease name is intended to prevent AIDS.

In addition, as a means for pulverizing HIV, Poliovirus (PV), IFV, malaria parasite, or trypanosoma protozoa (hereinafter abbreviated as HIV or malaria parasite) into fine powder, it is cultured and proliferated. The HIV or malaria parasite as described above may be used as described below to make the HIV or malaria parasite a non-toxic antigen that can be used as a vaccine.

Furthermore, as a means of pulverizing HIV or malaria parasite (hereinafter abbreviated as HIV), the HIV in the liquid is crushed using a nanomizer and cultured to proliferate. After inactivation of HIV, for example at −30 ° C.
For the purpose of drying HIV existing in the culture broth that has been cultivated by freezing and vacuum drying (hereinafter abbreviated as lyophilization or freeze-drying) in a vacuum state of kPa or less. Then, after drying HIV by freeze-drying, using a mortar, stone mill, ball mill, and jet mill (hereinafter abbreviated as jet mill), for example, HIV having a particle diameter of 120 nm is reduced to 10 nm or less. After pulverization, the fine powder obtained by pulverizing HIV is firstly made of a polymer film using an aqueous solution or an aqueous ethanol solution (hereinafter referred to as an ethanol aqueous solution), for example, a Cuprophane film, The diameter of the pore formed in the hollow fiber made of a polymer membrane such as Pan membrane, PMMA membrane, glomerular membrane, PA membrane, PS membrane, and peritoneum is, for example, 30 mm (3 nm), 40 mm (4 nm) 70 mm (7 nm), 100 (10 nm), 200 mm (20 nm), or other dialysis hollow fibers using a hollow system with a pore size that is a pore size, or artificial dialysis intended for use in plasma fractionation hollow fibers For example, a pore size formed on a hollow fiber made of a polymer membrane as a filter intended to be separated by filtering to a particle size of fine particles of 10 nm or less using Using a hollow fiber made of a polymer membrane having a membrane pore size, for example, HIV-1 Gag having a molecular weight of 20,000
A filtration method for forming an HIV vaccine characterized by filtering p24 or filtering HIV-1Gag p24 having a molecular weight of 24,000 using a filter having a pore size of 100 μm.

Further, after pulverizing the plasma component obtained by separating the plasma component from the blood component of whole blood containing HIV, it is made of a polymer film, for example, Cuprophane film, Pan film, PMMA film, glomerular film, PA The membrane pore diameter formed in the hollow fiber made of a polymer membrane such as a membrane, PS membrane, and peritoneum is, for example, 30 mm (3 nm), 40 mm (4 nm), 70 mm (7 nm), 100 mm (10 nm), An artificial dialysis analyst intended for use in a hollow fiber for artificial dialysis using a hollow fiber having a pore size of 200 mm (20 nm) or other pore size, or a hollow fiber for plasma fractionation. Using, for example, fine particles having a particle size mixed in the supernatant after centrifuging an aqueous ethanol solution obtained by crushing plasma components of whole blood containing HIV, Fill intended to be separated by filtering the particle size For example, for the purpose of filtering in stages, using hollow fibers made of polymer membranes with a pore size of pores formed in hollow fibers made of polymer membranes. If you filter first with a 200 大 き い large pore size filter and then with a second 100 、 then the next smaller pore size filter, a virus such as HIV with a large particle size A filtration method aimed at forming an HIV vaccine characterized by completely preventing excessive contamination.

In addition, HIV that is the causative virus of AIDS patients, or other causative viruses such as HCV, HSV, IFV, and HPV that are causative viruses of infectious diseases, or bacteria that cause infectious diseases such as Mycobacterium tuberculosis Species cells or protozoa that cause infectious diseases such as malaria parasites, trypanosoma protozoa, spirochete parida parasites (hereinafter abbreviated as HIV) are, for example, crushed into fine powders of 10 nm or less, and HIV For the purpose of forming a vaccine, HIV contained in a culture medium in which HIV is cultured is pulverized into, for example, a fine powder of 10 nm or less, and is 100% safe as a vaccine whose disease name is AIDS. An antigen-antibody complex against HIV by providing a vaccine for the purpose of protecting HIV in a very short time and at a very low cost with a vaccine capable of becoming an antigen. A disease name characterized by the aim of causing the disease name to establish an immune memory against AIDS in the human body and acquiring autoimmunity in the human body to cause the disease name to prevent AIDS. The method and the treatment method are used as solving means.

The names of the diseases are malaria, childhood paralysis, tuberculosis, sleeping sickness, nagana disease, leishmaniasis, Chagas disease, schistosomiasis, onchocercosis, ocular complications, medinaminosis, dengue fever, AIDS, and yellow fever (hereinafter abbreviated). Thus, a therapeutic means for the human body to acquire autoimmunity against symptoms such as malaria or HIV) is provided.

Infectious diseases such as HCV, HSV, IFV, HPV and other infectious diseases such as Mycobacterium tuberculosis, whose disease name is HIV, which is the causative virus of AIDS patients, and other infectious diseases, as described above The cells of the bacterial species causing the infection or the protozoa causing the infection such as malaria parasite, trypanosoma protozoa, and spirochete parida parasite (hereinafter abbreviated as HIV) are crushed into fine powders of 10 nm or less, for example. Then, for the purpose of forming an HIV vaccine, after inactivating the HIV containing the culture medium in which HIV was cultured after lyophilization using Nanomizer, Using a jet mill, the blood component of whole blood containing HIV, or the blood component of whole blood excluding blood cells, and the plasma component consisting of serum and fibrin (hereinafter referred to as the blood component) For example, a plasma component or a blood component of whole blood is pulverized into a fine powder of 10 nm or less, and a plasma component separated from the blood component of whole blood collected from an AIDS patient by disease name is used. Using a vaccine that can be a 100% safe antigen in a very short time and at a very low cost, providing a vaccine for the purpose of protecting HIV and allowing the human body to form an antigen-antibody complex against HIV The disease name is intended to establish an immune memory against AIDS in the human body, acquire autoimmunity in the human body and prevent the disease name from preventing AIDS, And a method of treatment.

Furthermore, HIV or Malaria parasite (PV), or IFV, or malaria parasite, or trypanosoma protozoa (hereinafter abbreviated as HIV or malaria parasite) is pulverized into a fine powder. When pulverized using the pulverization means described below to form a non-toxic antigen that can be a vaccine, or HIV, or Poliovirus (PV), or IFV, or malaria parasite, or trypanosoma protozoa (hereinafter abbreviated) As a means for crushing HIV or malaria parasite), the blood component of whole blood contained in the animal or human body infected with HIV or malaria parasite, or the blood component of whole blood, The plasma component after separation into a blood cell part and a plasma part by applying a centrifuge is used for the activity of coconut shell activated carbon or petroleum pitch system. Charcoal to make the adsorption. Thereafter, coconut shell activated carbon that was collected from a human body infected with HIV and adsorbed plasma components separated from blood was used as a mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill). To use)
The following three items are used as means for forming a non-toxic antigen.

(1)
HIV or malaria protozoa grown by cultivating HIV or malaria parasite is an inorganic substance such as zeolite having a particle diameter of about 2 to 100 mm, coconut shell activated carbon, or petroleum pitch-based activated carbon. After adsorbing the culture solution, HIV or malaria parasite is filtered using a mortar, stone mortar, ball mill, and jet mill (hereinafter, abbreviated as jet mill), such as HIV with a particle size of 10 nm. When filtered using a membrane, the tablets shown in Table 22, Table 23 and Table 33 for the purpose of forming a non-toxic antigen whose disease name is intended to prevent AIDS and can be a vaccine for AIDS, Or as a raw material for injections.

(2) HIV or malaria parasites adsorbed on cereals or beans such as brown rice, white rice, wheat, red beans or soybeans, which are organic substances, cultured and proliferated by protozoa, and freeze-dried Then, HIV or malaria parasite is filtered using a filter membrane having a diameter of 10 nm such as HIV using a mortar, stone mill, ball mill, and jet mill (hereinafter abbreviated as jet mill). In order to form a non-toxic antigen whose disease name is for the prevention of AIDS and can be a vaccine for AIDS, it is used as a raw material for tablets or injection solutions shown in Table 22, Table 23 and Table 33.

(3) HIV or malaria parasites cultured and grown on crystalline cellulose, dextrin, alum, calcium, etc. that are harmless to the human body are adsorbed and ground or freeze-dried After that, using HIV or a malaria parasite using a mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill), a filtration membrane having a particle diameter of 10 nm such as HIV is used. The raw materials of the tablets or injection solutions shown in Table 22, Table 23, and Table 33 for the purpose of forming a non-toxic antigen that can be a vaccine for AIDS whose disease name is intended to prevent AIDS after filtration. And

In addition, using the coconut shell activated carbon, petroleum pitch-based activated carbon, white rice, or calcium, as described above, means for forming a vaccine whose disease name is AIDS, malaria, sleeping sickness, and Nagana disease is as follows: 5 items.

(1)
After the culture medium grown by cultivating HIV is adsorbed on coconut shell activated carbon, the culture medium containing HIV adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon is left as it is. Grind or freeze-dry. Thereafter, using the coconut shell activated carbon adsorbing HIV, using a mortar, stone mill, ball mill, and jet mill (hereinafter abbreviated as jet mill), the coconut shell activated carbon adsorbing HIV and HIV Table 34 shows an aqueous solution or an ethanol aqueous solution in which coconut shell activated carbon and a fine powder obtained by pulverizing HIV together are dissolved using an aqueous solution or an ethanol aqueous solution. When filtration is performed using a filtration membrane having a PMMA membrane with a pore size of 10 nm, a non-toxic antigen whose disease name is an AIDS vaccine for the purpose of preventing AIDS can be formed.

(2) Blood components collected from a human body infected with HIV, which has been voted from a patient whose disease name is AIDS, is separated into a blood cell part and a plasma part by centrifuging the blood. Adsorption onto coconut shell activated carbon or petroleum pitch-based activated carbon. Thereafter, the coconut shell activated carbon that was collected from a human body infected with HIV and adsorbed the plasma component separated from the blood was used as a mortar, a stone mortar, a ball mill, and a jet mill (hereinafter abbreviated as jet mill). And then pulverizing the coconut shell activated carbon adsorbing HIV and HIV together into a fine powder and then pulverizing the coconut shell activated carbon and HIV together using an aqueous solution or an ethanol aqueous solution. When an aqueous solution in which powder is dissolved or an aqueous ethanol solution is filtered using a filtration membrane having a PMMA membrane pore diameter of 10 nm as shown in Table 34, the disease name is intended to prevent AIDS. A non-toxic antigen that can be a vaccine can be formed.

(3) A culture solution containing HIV that has been adsorbed on coconut shell activated carbon after adsorbing the culture solution obtained by culturing and proliferating the malaria parasite on coconut shell activated carbon or petroleum pitch-based activated carbon, Using a mortar, stone mill, ball mill, and jet mill (hereinafter abbreviated as jet mill), coconut shell activated carbon adsorbing malaria parasite and malaria parasite are pulverized together into fine powder, then aqueous solution Or an aqueous solution in which a fine powder obtained by pulverizing coconut shell activated carbon and malaria parasite using an aqueous ethanol solution or an aqueous ethanol solution is shown in Table 34, and the membrane pore size of the PMMA membrane is 10 nm. Filtration using a membrane can form a non-toxic antigen that can be a malaria vaccine whose disease name is intended to prevent malaria.

Further, viruses such as HCV, HSV, IFV, HPV, etc. which are the causative viruses of HIV or other infectious diseases, or cells of bacterial species causing infectious diseases such as Mycobacterium tuberculosis, or malaria parasite, trypanosoma protozoa, spirochete On the surface of a protozoan (hereinafter, abbreviated as HIV) that causes infectious diseases such as Parida protozoa, a high potential anode is charged. Coconut shell activated carbon or petroleum pitch-based activated carbon has an adsorption area of about 1,500 times. Furthermore, since the surface of the activated carbon is charged, it is intended to adsorb and crush viruses such as HIV, cells of bacterial species such as Mycobacterium tuberculosis, or protozoa such as malaria parasite.

In addition, the present invention is the largest infectious disease on earth, and 300 to 700 million people are infected per year, and more than 2 million people die per year. The name of the disease can be used to eradicate malaria by heating the mosquitoes that transmit the malaria parasite, the causative agent of the disease, in the air using electromagnetic waves and killing the mosquitoes.

Furthermore, the present invention is based on the idea that sleep disease, which is estimated that 400,000 people are infected every year in Central Africa and 60,000 people die, is the infection of Trypanosoma protozoa, a parasite mediated by the fly fly. Develops in By using the electromagnetic wave to kill the sleeping sickness fly using electromagnetic waves in the range that does not affect the human body, cattle, and horses, use the cows in the vast undeveloped farmland in central Africa It can be used to be able to cultivate.

The present invention also relates to sleep diseases caused by malaria and trypanosomiasis, AIDS, hepatitis, influenza, papillomavirus (HPV), endometrial cancer, cervical cancer, vaginal chlamydia, resistant tuberculosis And catechin which is a catechin simple substance or a mixture of catechin and chloroquine as a therapeutic means for a patient who develops an infection due to infection such as resistant syphilis (hereinafter referred to as infectious disease). Oral administration of a chloroquine complex, or a catechin and chloroquine derivative, or a catechin and artesunate complex, or a catechin and artesunate complex, or a catechin and artesunate derivative as a therapeutic agent. Using therapeutic means such as intravenous, intraperitoneal, intramuscular, and infusion. A, sleeping sickness, AIDS, C hepatitis, influenza, papillomavirus, vaginal chlamydia, resistant Mycobacterium tuberculosis, and infectious diseases such as resistance syphilis, or can be utilized as a means of treating cancer cells.

Further, in the present invention, in developing countries, for example, in sub-Saharan Africa, the cause of the spread of AIDS patients is that the number of AIDS patients is increasing due to sexual activity by prostitution by prostitutes. The first reason is why there are so many AIDS patients in Africa. Therefore, the number of prostitutes will increase. Naturally, AIDS patients also become an increasing chain of poverty. As a means to block this poor chain, the contraceptive effect of the present invention and the vaginal disinfectant (Micro
bicide) by providing contraceptives with both effects to prostitutes, and having them use contraceptives that have both effects at the stage of sexual activity. The contraceptive of the present invention, which also serves as an intravaginal disinfectant, can be used as a means to block the poor chain that increases and increases.

In addition, after crushing blood components of whole blood containing HIV, it is made of a polymer film, for example, Cuprophane film, Pan film, PMMA film, glomerular film, PA film, PS film, and peritoneum The membrane pore diameter formed in the hollow fiber made of a polymer membrane such as 30 mm (3 nm), 40 mm (4 nm),
Used as a hollow fiber for artificial dialysis using a hollow fiber having a pore size of 70 mm (7 nm), 100 mm (10 nm), 200 mm (20 nm), or other pore sizes, or a hollow fiber for plasma fractionation Fine particles of particle size mixed in the supernatant after crushing the blood components of whole blood containing HIV using an analyzer for artificial dialysis For example, as a filter intended to be separated by filtering to a particle size of fine particles of 30 nm or less, a high pore having a pore size formed in a hollow fiber made of a polymer membrane is formed. Using hollow fibers made of molecular membranes, eg 2
Use a filter with a large pore size of 00 cm, filter with a second filter size of 100 cm, then the next smaller pore size filter, and use a very small pore size filter with a third size of 70 cm If filtration is performed, a filtration method for the purpose of forming an HIV vaccine characterized by completely preventing the virus such as HIV having a large particle size from being excessively mixed can be obtained.

Claims (43)

Representative mosquitoes that transmit malaria parasites, trypanosoma protozoa, various viruses, and bacteria that are pathogens such as malaria, sleepiness, dengue fever, Japanese encephalitis, and yellow fever, to the human body,
Alternatively, a method and an apparatus for heating and killing a spotted mosquito in the air using electromagnetic waves on a fly fly (hereinafter abbreviated as a spotted mosquito). An electromagnetic wave oscillated using an oscillation source such as a magnetron, a surface wave vibration, a pulse wavelength, and a solid vibration (hereinafter, abbreviated as a crystal resonator) is emitted and irradiated in the air.
A method and an apparatus for killing by killing the spotted mosquito according to claim 1 by heating in air using electromagnetic waves. This is a US patent publication that describes the processing means invented and discovered by the inventor Yoshiaki Nagaura.
Uses a sinusoidal electromagnetic wave that has directivity and linearity that is amplified using a crystal resonator processed using the processing method of crystal resonator described in US6,952,074B2 as an oscillation source Then, the method and apparatus for killing and killing the spotted mosquito according to claim 1 and 2 by heating in the air using electromagnetic waves. The purpose is to kill the dead fly that clings to the surface of the body skin of the cow or horse body using the electromagnetic wave to kill the fly fly that mediates the Trypanosoma protozoa that causes the sleepiness disease using electromagnetic waves. A method and an apparatus for killing by killing the fly fly according to claim 1, 2 and 3 by heating in the air using electromagnetic waves. Using electromagnetic waves, mainly affecting the human body, for example, as a means of treating athlete's foot that develops due to vesicular tinea on the toes or fingertips of the human body, or the fingers or fingertips of the hand The bacteria and fungi that cause athlete's foot to infest the stratum corneum inside the skin by irradiating the fingertips of the human foot or the fingertips of the hands with electromagnetic waves using the output within the range that does not give And, by using microwaves, which are electromagnetic waves, for example, the spirococcus trichophyton is heated to around 65 ° C for about 20 seconds to denature the proteins that make up the athlete's foot. A method for killing and killing athlete's foot according to claim 1, 2, 3, and 4 using electromagnetic waves for the purpose of killing,
And its equipment. Catechin in the blood of patients with disease names malaria, sleepiness, AIDS, hepatitis C, adult leukemia, dengue fever, Japanese encephalitis, yellow fever, tuberculosis, cancer cells, and influenza (hereinafter abbreviated as infectious disease) Is administered intravenously, intraperitoneally, intramuscularly, intravenously, and orally (
(Hereinafter, referred to as intravenous administration or oral administration for short) to treat infection, tuberculosis bacteria, or cancer cells. When catechin is administered intravenously for the purpose of treating infection using catechin, catechin containing no caffeine is used inside the total catechin content or catechin having a total catechin content The percentage of caffeine with respect to the content of 0%, or 6% or less, or 10
% Or less of catechins containing caffeine, which is administered intravenously to treat infectious diseases. . When catechin is administered intravenously for the purpose of treating infection using catechin, the mixing ratio of epigallocatechin gallate (EGCg) within the total catechin content is 90% or less, or 80% or less, or 6 for the purpose of treating infections, tuberculosis or cancer cells by intravenous administration using catechins containing a total catechin content of 70% or less, or 60% or less, And a method of therapeutic means comprising treating the infectious disease according to 7. Treats infections, tuberculosis bacteria, or cancer cells by intravenous or oral administration of catechin and quinine, catechin and chloroquine, or catechin and artesunate, such as Sanphenon BG-3 or Polyphenone 70S. The method of the treatment means characterized by treating the infectious disease of said 6, 7, and 8 aiming at that. When catechin is administered orally for the purpose of treating infectious diseases using catechins, the total catechin content contains caffeine with a mixing ratio of caffeine of 5% or more. The above-mentioned 6, 7 for the purpose of treating infection, tuberculosis or cancer cells by oral administration using catechin mixed with caffeine containing catechin content. A method of therapeutic means comprising treating the infectious disease according to claim 8, 8, and 9. Catechin is intravenously administered in the blood for the purpose of killing cancer cells in the blood where cancer cells float in the blood and metastasize to various organs using catechin. Cancer cells can be killed by chemically covalently binding to cancer cells. This phenomenon
The purpose is to prevent cancer cells from floating and metastasizing in the blood using catechins.
A method of therapeutic means characterized in that the infection according to claim 6, 7, 8, 9, and 10 is treated. Catechin (hereinafter abbreviated as EGCg, or catechin) slips through the inside of the cell. A peptide in which multiple amino acids are connected is mixed with catechin and mixed to form a liquid.
Developed nasal sprays that are applied to the mucous membrane of the nose, or sprayed into the nose, or sprayed into the mouth,
Using a peptide that has the property of passing through the inside of the cell with the absorption rate of catechin, the absorption rate of catechin was increased, and the disease name is influenza, rotavirus, norovirus, malaria parasite, which is the causative virus of acute gastroenteritis, or It is characterized by a therapeutic means for treating infectious diseases such as cancer cells. Tea leaves as a treatment for treating malaria, sleeping sickness, AIDS, hepatitis, adult leukemia, influenza, resistant tuberculosis, resistant syphilis, and cancer cells (hereinafter abbreviated as infectious diseases) In the human intestinal tract, the diameter of the tea powder is about 50μ.
If the powder of tea leaves is less than m, the powder of tea leaves directly into the intestinal tract without being decomposed and digested in the stomach and intestinal tract of the human digestive organs. It is characterized by the fact that it is taken in, the fine powder of tea leaves is taken into the blood, and it is decomposed directly in the liver and kidney which are human organs. The human body orally administers fine powder of tea leaves in the form of tablets, granules, capsules, powders (hereinafter abbreviated as tablets or catechin tablets), or enteric coatings with enteric coating on them. By doing this, the fine powder of tea leaves in the human intestinal tract is not broken down into the blood of the human body without breaking down the fine powder of tea leaves in the stomach and intestinal tract, which are the digestive organs of the human body. Directly ingested to take in the tea leaf fine powder into the blood, decompose the tea leaf fine powder directly in the human liver and kidneys, the tea leaf fine powder contains Catechins, or complex polysaccharides are produced and diffused in the blood, using the antibacterial effect, or antiviral effect, or antiprotozoal effect of catechins, the disease name is influenza, AIDS, resistant malaria, or Russia, the causative virus of acute gastroenteritis Virus, characterized in that for the purpose of treatment means of infectious diseases such as norovirus. The human body orally administers fine powder of tea leaves in the form of tablets, granules, capsules, powders (hereinafter abbreviated as tablets or catechin tablets), or enteric coatings with enteric coating on them. By doing this, the fine powder of tea leaves in the human intestinal tract is not broken down into the blood of the human body without breaking down the fine powder of tea leaves in the stomach and intestinal tract, which are the digestive organs of the human body. Directly ingested to take in the tea leaf fine powder into the blood, decompose the tea leaf fine powder directly in the human liver and kidneys, the tea leaf fine powder contains Catechins or complex polysaccharides are produced in the blood to lower the blood glucose level in the blood and serve as a therapeutic means for diabetes. Or, the powder of tea leaves contains fat, sugar chains, proteins, and other waste products (hereinafter abbreviated as waste products) accumulated in the blood vessel and deposited on the inner wall of the blood vessel. High blood pressure for the purpose of lowering the blood pressure of the human body to normal blood pressure by binding waste catechins and complex polysaccharides and waste products to excrete waste products outside the human body It is characterized by being a treatment means. It is characterized in that a fine powder of tea leaves and quinine, chloroquine, or artesunate are mixed and used as a therapeutic means for the treatment of infectious diseases such as resistant malaria parasite and sleeping sickness. It is intended to kill sperm using catechin, which is effective as a contraceptive and also serves as an antibacterial microbicide that protects against infections such as AIDS virus, hepatitis virus, and papilloma virus. And Cocoa, cocoa butter, cacao mass, whole milk powder, whey powder, skim milk powder, vegetable oils, chickenpox, reduction for the purpose of lowering blood glucose level, lowering blood pressure, or preventing or treating infections such as influenza Chickenpox, trehalose, cream powder, gelatin, wafer powder, mochi powder, cellulose, emulsifier (from soybean), gelling agent (pectin), brightener, and fragrance as the raw material are chocolate, and the central part is starch syrup A powder of tea leaves is placed inside the glutinous rice cake, which is made of glutinous powder, with a central portion of the glutinous chocolate, and a peripheral structure made of chocolate. The purpose of lowering blood glucose levels mixed or mixed, or the purpose of lowering blood pressure, or influenza or rotavirus Characterized in that for the purpose of preventing and treating infectious diseases such as acute gastroenteritis onset caused. Hybromellose phthalate (hereinafter referred to as green tea) at the stage of tea leaves (hereinafter abbreviated as green tea) with a size of around 2mm to 5mm, which is a raw material for the purpose of forming fine powder of tea leaves Enteric coating on the surface of green tea leaves and inside of green tea leaves using enteric coating materials such as HPMCP (abbreviated HPMCP), or Twein, or shellac (hereinafter abbreviated HPMCP) Infiltrate the material, enter the green tea leaf surface and inside the green tea leaf using enteric coating material such as HPMCP, enteric coating the green tea leaf into the digestive organ stomach In this case, malaria and acute gastroenteritis are administered by oral administration of green tea leaves after processing for the purpose of intestinal solvent, which is intended to be dissolved in the intestinal tract and ingested without digestion. Flu, AIDS, hepatitis, Infectious diseases such as human leukemia, or adult diseases such as diabetes, hypertension, anticancer, hay fever, or functional foods such as cereal, chocolate, gummy candy, potato chips, rice crackers, and bread, or drinking water, Adhering green tea leaves that have undergone enteric coating processing inside carbonated drinking water, alcoholic drinking water (hereinafter abbreviated as candy), and forming mixed candy and treating infectious diseases and adult diseases The therapeutic means is characterized by the purpose of treatment. Hybromellose phthalate (hereinafter referred to as green tea) at the stage of tea leaves (hereinafter abbreviated as green tea) with a size of around 2mm to 5mm, which is a raw material for the purpose of forming fine powder of tea leaves Enteric coating on the surface of green tea leaves and inside of green tea leaves using enteric coating materials such as HPMCP (abbreviated HPMCP), or Twein, or shellac (hereinafter abbreviated HPMCP) Infiltrate the material, enter the green tea leaf surface and inside the green tea leaf using enteric coating material such as HPMCP, enteric coating the green tea leaf into the digestive organ stomach In order to dissolve in the intestinal tract and take it in the body without digestion, the dosage form is tablets and granules using green tea leaves after processing for enteric solvent , Capsules, powders, syrups, or Luo, again, enteric coating processed intestines solvent (
(Hereinafter referred to simply as tablets, catechin tablets, or enteric solvents) by oral administration, infections such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia, or diabetes,
A therapeutic means characterized by treating adult diseases such as hypertension, anticancer and hay fever. Tea leaf stage (hereinafter abbreviated as raw material for the purpose of forming fine powder of tea leaves,
Of green tea using enteric coating materials such as hybromellose phthalate (hereinafter abbreviated as HPMCP), zein or shellac (hereinafter abbreviated as HPMCP) The enteric coating material is infiltrated on the leaf surface and inside the green tea leaf, and the green tea leaf is used on the surface of the green tea leaf and inside the green tea leaf using an enteric coating material such as HPMCP. After processing the enteric coating for the purpose of ingestion into the body by dissolving it in the intestinal tract without digesting it in the stomach, the digestive organ The green tea leaves were pulverized by means of a mill, ball mill, jet mill or the like to give a particle diameter of 50 μm or less, or a particle diameter of 50 μm or more. Acute gastroenteritis, influenza Foods such as infectious diseases such as Nanza, AIDS, hepatitis, adult leukemia, adult diseases such as diabetes, hypertension, anticancer, hay fever, or functional cereal, chocolate, gummy candy, potato chips, rice crackers, bread Or, confectionery is formed by adhering and mixing fine powder of tea leaves that have undergone enteric coating processing inside drinking water, carbonated drinking water, alcoholic drinking water (hereinafter abbreviated as candy). Infectious diseases,
And a therapeutic means characterized by treating adult diseases. Hybromellose phthalate (hereinafter abbreviated as HPMCP) at the stage of tea leaves (hereinafter abbreviated as green tea), which is a raw material intended to form fine powder of tea leaves,
Or enteric coating material is infiltrated on the inside of green tea leaf surface and inside green tea leaf using enteric coating material such as Twein or Shellac (hereinafter abbreviated as HPMCP). Using enteric coating material such as HPMCP on the surface of the leaf and inside the green tea leaves, enteric coating the green tea leaves without digestion inside the stomach, the digestive organ The size of the particle size of the green tea leaves after being processed for the purpose of enteric solvent, using a mortar, ball mill, jet mill, etc. The dosage form is tablets, granules, capsules, powders, syrups, or enteric coating again using fine powder of tea leaves with a particle size of 50 μm or less, or 50 μm or more Enteric solvent (hereinafter abbreviated) Or tablets) The therapeutic means is characterized by the purpose of treating adult diseases. A fine powdered catechin purified by hot water extraction from tea leaves (hereinafter abbreviated as green tea) is a tablet, granule, capsule, powder, syrup, or their surface,
Or enteric coating processed using enteric coating materials such as HPMCP, or twein, or shellac inside (hereinafter abbreviated as tablets, catechin tablets, or catechins as enteric solvents) Orally administered malaria, acute gastroenteritis, influenza,
A therapeutic means characterized by treating infectious diseases such as AIDS, hepatitis, adult leukemia, or adult diseases such as diabetes, hypertension, anticancer, hay fever. Enteric coatings such as HPMCP, zein, or shellac (hereinafter abbreviated as twein) are catechins in the form of fine powder that have been purified by extracting with hot water from tea leaves (hereinafter abbreviated as green tea). Enteric coating processed using the material (hereinafter abbreviated as tablet, catechin tablet, or catechin as enteric solvent) is orally administered to malaria,
Infectious diseases such as acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia, or diabetes,
A therapeutic means characterized by treating adult diseases such as hypertension, anticancer and hay fever. Enteric coatings such as HPMCP, zein, or shellac (hereinafter abbreviated as twein) are catechins in the form of fine powder that have been purified by extracting with hot water from tea leaves (hereinafter abbreviated as green tea). Tablets, granules after the dosage form has been processed into tablets, granules, capsules, powders, syrups of catechin in a fine powder state that has been enteric-coated using materials
Enteric solvent coated with enteric coating material using enteric coating material such as HPMCP, or twein, or shellac again on or inside the capsule, powder, syrup
Hereinafter, abbreviated as tablets, catechin tablets, or catechins as intestinal solvents), orally administered to infectious diseases such as malaria, acute gastroenteritis, influenza, AIDS, hepatitis, adult leukemia, or diabetes, hypertension And a therapeutic means characterized by treating adult diseases such as anti-cancer and hay fever. A molecular weight of 4 from bancha, sencha, and green tea (hereinafter abbreviated as green tea) containing complex polysaccharides that are effective in hypoglycemic action, anticancer action, and infectious diseases such as malaria and influenza. Blood glucose levels in the blood such as L-arabinose, D-ribose, D-glucose, or D-mannose, L-sorbose (hereinafter abbreviated as complex polysaccharides), which have a blood glucose lowering effect From a green tea characterized by producing a polysaccharide having a high purity of 99% or more by extracting and purifying a hypoglycemic substance having a reducing effect or a complex polysaccharide having an anticancer effect from green tea A method for purifying complex polysaccharides. Malaria parasite or mosquito after drying malaria protozoa whose disease name is a pathogen of malaria, or an anopheles mosquito that malaria parasite is lurking in the salivary gland (hereinafter, abbreviated as malaria parasite or mosquito) Using an alkaline ethanol aqueous solution with a PH concentration of 8.0 or more, the active ingredient that is the antigen of malaria parasite or mosquito is extracted by alkali and purified. To form an antigen-antibody complex in the human body by subcutaneous injection, intravenous administration, or oral administration, and to establish an immune memory against malaria in the human body and to acquire autoimmunity in the human body The name of the disease characterized by the purpose is a treatment method for malaria. The advantage of making the blood component of whole blood containing the disease name HIV into a fine powder by putting it in liquid nitrogen at -196 ° C is the advantage that it can be completely destroyed from the smallest parvovirus to the cells of malaria parasite There is. The blood component of whole blood containing HIV is frozen very slowly at a temperature of around −10 ° C. to expand the water inside the cells, and then the blood of whole blood containing HIV. When the components were made into a particle diameter of several millimeters to several centimeters in a room of -30 degrees C to -50 degrees C and pulverized with a zet mill at the same room temperature, even with parvovirus having a small particle diameter of 30 nm, It was discovered that it can be pulverized with an ultra-low temperature jet mill. The advantage that the blood component of whole blood containing HIV is made into a fine powder by putting it in liquid nitrogen at −196 ° C. is advantageous in that it can be completely destroyed from cells from very small parvovirus to malaria parasite. .
Since the ultra-low temperature zet mill described above does not heat, the virus is not denatured, and thus a harmless vaccine can be provided at a very low cost. Other application fields of the ultra-low temperature jet mill include electronic parts such as lithium ion batteries, cosmetics and pharmaceutical materials. For example-
In a room of 10 ° C to -50 ° C, after the particle diameter of several millimeters to several centimeters is pulverized by this zet mill, even with a material having a small particle diameter of 30 nm, It can be pulverized to 10 nm or less. Since the ultra-low temperature zet mill described above does not heat, the virus is not denatured, and thus a harmless vaccine can be provided at a very low cost. Using the blood components of whole blood collected from the human body, 100% miscellaneous viruses, bacteria and protozoa such as malaria parasite are 100% non-toxic and harmless antigens at all. In order to form a vaccine using a blood component of whole blood collected from the human body, the parvovirus currently found on the earth has a size of 30 nm. Red blood cells, white blood cells, platelets, various miscellaneous viruses, various miscellaneous bacteria, and miscellaneous protozoa in the blood components are reduced to a size of 30 nm or less of the size of the barbovirus, and the ultra low temperature zet mill How to grind with. The blood component of whole blood containing HIV collected from the human body is frozen very slowly at a temperature of around −10 ° C. to expand the water inside the cell, and then the whole blood containing HIV. The blood component of blood is set to a particle diameter of several mm to several cm in a room of -10 degrees C to -50 degrees C,
When pulverized with a Zet mill at the same room temperature, even parvovirus with a small particle size of 30 nm,
Temporary name that can be pulverized by the above ultra-low temperature jet mill, an ultra-low temperature jet mill pulverization method. In the tentative name, ultra-low temperature zet mill pulverization method described in claims 28 and 29 above, red blood cells, white blood cells, platelets, and various viruses existing in the blood components of whole blood collected from the human body, A method in which various kinds of bacteria and various kinds of protozoa are pulverized to a size of 30 nm or less with an ultra-low temperature zet mill. Since the peptide, protein, sugar chain, and lipid constituting the fine powder are not heated, the virus is not denatured, so that a harmless vaccine can be provided at a very low cost, and a tentative name, an ultra-low temperature jet mill grinding method. The provisional name, ultra-low temperature zet mill described in claims 28, 29, and 30 above, includes electronic parts such as lithium ion batteries, cosmetics and pharmaceutical materials as other application fields. For example-
After a particle diameter of several millimeters to several centimeters in a room of 10 degrees C to -50 degrees C is pulverized by this zett mill, even a material having a small particle diameter of 30 nm is less than 10 nm by the ultra-low temperature zett mill. Can be pulverized to solve medical, energy, and environmental problems. In addition, after crushing blood components of whole blood containing HIV, it is made of a polymer film, for example, Cuprophane film, Pan film, PMMA film, glomerular film, PA film, PS film, and peritoneum The membrane pore diameter formed in the hollow fiber made of a polymer membrane such as 30 mm (3 nm), 40 mm (4 nm),
Used as a hollow fiber for artificial dialysis using a hollow system with a membrane pore size of 70 mm (7 nm), 100 mm (10 nm), 200 mm (20 nm), or other pore sizes, or a hollow fiber for plasma fractionation Fine particles of particle size mixed in the supernatant after crushing the blood components of whole blood containing HIV using an analyzer for artificial dialysis For example, as a filter for the purpose of separating by filtering to a particle size of fine particles of 10 nm or less, a high pore having a pore size that is formed in a hollow fiber made of a polymer membrane is formed. Using hollow fibers made of molecular membranes, for example, HIV-1G with a molecular weight of 20,000
Hg characterized by filtering ag p24 or filtering HIV-1 Gag p24 having a molecular weight of 24,000 using a filter having a pore size of 100 μm.
Filtration method to form a vaccine for IV. In addition, after crushing blood components of whole blood containing HIV, it is made of a polymer film, for example, Cuprophane film, Pan film, PMMA film, glomerular film, PA film, PS film, and peritoneum The membrane pore diameter formed in the hollow fiber made of a polymer membrane such as 30 mm (3 nm), 40 mm (4 nm),
Used as a hollow fiber for artificial dialysis using a hollow fiber having a pore size of 70 mm (7 nm), 100 mm (10 nm), 200 mm (20 nm), or other pore sizes, or a hollow fiber for plasma fractionation Fine particles of particle size mixed in the supernatant after crushing the blood components of whole blood containing HIV using an analyzer for artificial dialysis For example, as a filter for the purpose of separating by filtering to a particle size of fine particles of 10 nm or less, a high pore having a pore size that is formed in a hollow fiber made of a polymer membrane is formed. Using hollow fibers made of molecular membranes, eg 2
Use a filter with a large pore size of 00 cm, filter with a second filter size of 100 cm, then the next smaller pore size filter, and use a very small pore size filter with a third size of 70 cm A filtration method aiming at forming an HIV vaccine characterized by completely preventing the virus such as HIV having a large particle diameter from being excessively mixed if filtered. The name of the disease causes HIV, which is the causative virus of AIDS patients, or other causative viruses such as HCV, HSV, IFV and HPV, which are causative viruses of infectious diseases, or bacterial species that cause infectious diseases such as Mycobacterium tuberculosis Cells or protozoa (hereinafter abbreviated as HIV) that cause infections such as malaria parasites, trypanosoma protozoa, spirochete parida parasites,
For the purpose of crushing into fine powder of 0 nm or less, using a wet high-pressure pulverization machine (hereinafter abbreviated as Nanomizer) using the basic principle of the sterilization method with supercritical carbon dioxide,
A blood component of whole blood containing HIV or a blood component of whole blood containing HIV and a blood plasma component composed of serum and fibrin (hereinafter abbreviated as plasma component, Or blood component of whole blood), for example, by crushing to a fine powder of 10 nm or less and using the blood component or plasma component of whole blood collected from AIDS patients as the disease name, 100% safe Providing a vaccine that can protect against HIV in a very short time and at a very low cost, and allowing the human body to form an antigen-antibody complex against HIV. A method of preventing and treating AIDS, characterized by establishing an immune memory against the disease and causing the human body to acquire autoimmunity and causing the disease name to prevent AIDS. The name of the disease causes HIV, the causative virus of AIDS patients, or other causative viruses such as HCV, HSV, IFV, HPV, poliovirus, and other infectious viruses, or infections such as Mycobacterium tuberculosis For the purpose of crushing cells of fungal species or protozoa causing infectious diseases such as malaria parasites, trypanosomes parasites, spirochete parida parasites (hereinafter abbreviated as HIV) into fine powders of 30 nm or less, for example In addition, using a wet high-pressure pulverization machine or an ultrasonic crushing machine (hereinafter abbreviated as nanomizer or ultrasonic crushing machine) using the basic principle of a sterilization method using supercritical carbon dioxide, HI in AIDS patients
Blood component of whole blood containing V, or a blood component of whole blood excluding blood cells, a plasma component composed of serum and fibrin, or a culture solution in which HIV is cultured, or poliovirus, or others Artificial growth of viruses, or Mycobacterium tuberculosis or other bacterial species cells, malaria parasites, trypanosoma protozoa, or other protozoan microorganisms, or animal and plant tissues,
Alternatively, the grown culture fluid (hereinafter abbreviated as plasma component or blood component of whole blood or culture fluid) is crushed into fine powder of 10 nm or less, for example, and blood is collected from AIDS patients. The purpose is to protect HIV at a very low cost in an extremely short time with an antigen that can be a 100% safe antibody, using a blood component of whole blood, or a plasma component, or a culture solution in which HIV is cultured. 100
Create a safe antigen, form an antigen-antibody complex against HIV in the human body, establish an immune memory against AIDS in the human body, acquire autoimmunity in the human body, and name the disease A method for preventing and treating AIDS whose disease name is characterized by aiming to prevent AIDS. After cultivating and cultivating HIV, the culture solution containing HIV adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon is adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon. Using a ball mill and a jet mill (hereinafter abbreviated as a jet mill), coconut shell activated carbon adsorbing HIV and HIV are pulverized together into a fine powder, and then an aqueous solution or an ethanol aqueous solution is used. Then, when an aqueous solution in which coconut shell activated carbon and fine powder obtained by pulverizing HIV are dissolved, or an ethanol aqueous solution is filtered using a filtration membrane having a PMMA membrane with a pore diameter of 10 nm shown in Table 34, A vaccine for AIDS characterized by being capable of forming a non-toxic antigen capable of becoming a vaccine for AIDS whose disease name is for the purpose of preventing AIDS, and a method for processing the same. Blood collected from a human body infected with HIV, whose name is determined from a patient with AIDS, is separated into a blood cell part and a plasma part by centrifuging the blood, and the plasma component is coconut shell activated carbon. Alternatively, adsorption is performed on petroleum pitch-based activated carbon. Thereafter, coconut shell activated carbon that was collected from a human body infected with HIV and adsorbed plasma components separated from blood was used as a mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill). And then pulverizing the coconut shell activated carbon adsorbing HIV and HIV together into a fine powder, and then pulverizing the coconut shell activated carbon and HIV using an aqueous solution or an ethanol aqueous solution. When an aqueous solution in which ethanol is dissolved or an aqueous ethanol solution is filtered using a filtration membrane having a PMMA membrane pore diameter of 10 nm as shown in Table 34, the disease name becomes an AIDS vaccine with the aim of preventing AIDS. A vaccine for AIDS, which is capable of forming a non-toxic antigen and a method for processing the same. A culture solution containing malaria parasites adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon after cultivating malaria parasite is grown on coconut shell activated carbon or petroleum pitch-based activated carbon. After pulverizing the coconut shell activated carbon adsorbing the malaria parasite and the malaria parasite together into a fine powder using a millstone, ball mill, and jet mill (hereinafter abbreviated as a jet mill), an aqueous solution or ethanol An aqueous solution in which a fine powder obtained by pulverizing coconut shell activated carbon and malaria parasite using an aqueous solution is dissolved, or an aqueous ethanol solution, as shown in Table 34, using a filtration membrane having a PMMA membrane with a pore diameter of 10 nm. Malaria vaccine characterized by being able to form a non-toxic antigen that can be a vaccine for malaria whose name is intended to prevent malaria after filtration And the processing method. A culture solution obtained by culturing and proliferating Trypanosoma protozoa, which is a pathogen of sleeping sickness or Nagana disease, is adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon, and then Trypanosoma protozoa adsorbed on coconut shell activated carbon Using a mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill), the culture broth containing the coconut shell activated carbon adsorbing trypanosoma protozoa and HIV is finely mixed together. Table 34 shows an aqueous solution or an aqueous ethanol solution in which fine powder obtained by pulverizing coconut shell activated carbon and trypanosoma protozoa together using an aqueous solution or an aqueous ethanol solution after being pulverized into a powder is shown in Table 34. When filtering using a filtration membrane having a membrane pore diameter of 10 nm, the name of the disease is a sleeping sickness vaccine or Naga A sleep disease vaccine or a Nagana disease vaccine characterized by being capable of forming a non-toxic antigen that can be a vaccine for Na disease, and a processing method thereof. Patient with sleep sickness or nagana disease, l3 fuel ght range is approximately
2 cm, blood collected from livestock such as cattle or horses infected, blood collected from humans infected with Trypanosoma protozoa, or livestock such as cattle or horses, etc. The plasma component after separation into a part and a plasma part is adsorbed onto coconut shell activated carbon or petroleum pitch-based activated carbon. Thereafter, coconut shell activated carbon that was collected from a human body or cow and horse that was infected with Trypanosoma protozoa, adsorbed plasma components separated from blood, mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated, Coconut shell activated carbon and Trypanosoma protozoa adsorbing Trypanosoma protozoa together and pulverized into fine powder using an aqueous solution or ethanol aqueous solution, and then coconut shell activated carbon and Trypanosoma protozoa When the aqueous solution in which the fine powder obtained by pulverizing and the aqueous solution of ethanol or the aqueous ethanol solution is filtered using a filtration membrane having a PMMA membrane pore diameter of 10 nm shown in Table 34, the disease name is sleep disease or Nagana Sleep disease characterized by being able to form a non-toxic antigen that can serve as a vaccine for sleep disease or Nagana disease for the purpose of disease prevention Vaccine, Nagana disease vaccine, and processing method thereof. After the culture medium grown by cultivating HIV is adsorbed on coconut shell activated carbon, the culture medium containing HIV adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon is left as it is. Grind or freeze-dry. Thereafter, using the coconut shell activated carbon adsorbing HIV, using a mortar, stone mill, ball mill, and jet mill (hereinafter abbreviated as jet mill), the coconut shell activated carbon adsorbing HIV and HIV Table 34 shows an aqueous solution or an ethanol aqueous solution in which coconut shell activated carbon and a fine powder obtained by pulverizing HIV together are dissolved using an aqueous solution or an ethanol aqueous solution. , A PMMA membrane having a pore diameter of 10 nm is filtered to form an avirulent non-toxic antigen that can serve as an AIDS vaccine for the purpose of preventing AIDS. Vaccine and processing method thereof. Blood collected from a human body infected with HIV, whose name is determined from a patient with AIDS, is separated into a blood cell part and a plasma part by centrifuging the blood, and the plasma component is coconut shell activated carbon. Alternatively, adsorption is performed on petroleum pitch-based activated carbon. Thereafter, coconut shell activated carbon that was collected from a human body infected with HIV and adsorbed plasma components separated from blood was used as a mortar, stone mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill). And then pulverizing the coconut shell activated carbon adsorbing HIV and HIV together into a fine powder and then pulverizing the coconut shell activated carbon and HIV together using an aqueous solution or an ethanol aqueous solution. When an aqueous solution in which powder is dissolved or an aqueous ethanol solution is filtered using a filtration membrane having a PMMA membrane pore diameter of 10 nm as shown in Table 34, the disease name is intended to prevent AIDS. A vaccine for AIDS, which is capable of forming a non-toxic antigen that can be a vaccine, and a method for processing the same. A culture solution containing malaria parasites adsorbed on coconut shell activated carbon or petroleum pitch-based activated carbon after cultivating malaria parasite is grown on coconut shell activated carbon or petroleum pitch-based activated carbon. Using a mortar, ball mill, and jet mill (hereinafter abbreviated as jet mill), coconut shell activated carbon adsorbing malaria parasite and HIV are pulverized together into fine powder, then aqueous solution or ethanol An aqueous solution in which a fine powder obtained by pulverizing coconut shell activated carbon and malaria parasite using an aqueous solution is dissolved, or an aqueous ethanol solution, as shown in Table 34, using a filtration membrane having a PMMA membrane with a pore diameter of 10 nm. A malaria vaccine characterized by being capable of forming a non-toxic antigen that can be a malaria vaccine, with the disease name aimed at preventing malaria, upon filtration, and The processing method.