JP2010195760A - Method for exterminating malaria, sleeping sickness, aids and hepatitis c, and apparatus therefor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method and an apparatus therefor for killing anopheles or tsetse fly that transmit pathogens, influenza virus, bacteria of smallpox, Bacillus anthracis, Trichophyton, bacteria causing trichophytia pompholyciformis, etc., fungi, molds and viruses, to provide a means for treating infectious diseases such as malaria, sleeping sickness, AIDS, hepatitis C, influenza, etc., and to provide a means for treating resistant Mycobacterium tuberculosis or cancer cells. <P>SOLUTION: Causative viruses of various infectious diseases such as malarial parasite, Trypanosoma protozoan and AIDS virus each as causes of infections in human blood, or resistant Mycobacterium tuberculosis or cancer cells, are killed in blood by intravenous administration of a catechin or a catechin derivative in human blood or oral administration. Also, bacteria, fungi, and dermatophytosis as classified as trichophytia pompholyciformis as molds are killed using microwaves as electromagnetic waves. Further, cancer cells in blood afloat are killed in the blood by administering relevant patient(s) with a catechin or a catechin derivative, thus restraining cancer cells from metastases to various organs. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to malaria protozoa, trypanosoma protozoa, viruses and bacteria that are pathogens such as malaria, influenza, dengue fever, Japanese encephalitis, yellow fever, and sleepiness disease (hereinafter abbreviated as infectious disease) in the human body. The purpose is to kill a representative mosquito or a tsuetsue fly (hereinafter abbreviated as a mosquito mosquito or a fly fly) by heating it in the air using electromagnetic waves.

  Further, the present invention relates to the blood in a human body infected with malaria parasites, trypanosoma protozoa, Costaria schistosomiasis, and rat contracted nematodes (hereinafter abbreviated as malaria parasites or trypanosoma protozoa), or cows and horses. Malaria parasites or trypanosoma protozoa in the blood of human body are epigallocatechin (EGC), epicatechin (EC), gallocatechin (GC), catechin (C), epigallocatechin gallate (EGCg), epicatechin gallate (ECg) , Gallocatechin gallate (GCg), and catechin gallate (hereinafter abbreviated as catechin) are administered intravenously, intramuscularly, intraperitoneally, and intravenously (hereinafter abbreviated as intravenous administration). The malaria parasite or trypanosoma protozoa infected in the blood directly in the blood of the human body and cow and horse It aims to kill.

  In addition, the present invention provides for direct venous administration of catechin directly into the blood of agricultural cows that are infected with the parasite Trypanosoma parasite mediated by the fly fly, which is the cause of sleepiness. It aims at providing the treatment method of the sleepiness disease which is doing.

  The present invention also provides a means for treating infections such as AIDS virus (HIV), hepatitis C virus (HCV), influenza virus, or tuberculosis bacteria, or cancer cells (hereinafter referred to as infection). The purpose is to do.

  Furthermore, infectious diseases (hereinafter abbreviated as infectious diseases) infected by sexual acts such as AIDS virus (HIV), hepatitis C virus (HCV), papilloma virus (HPV), vaginal chlamydia, and syphilis, It is also intended to provide an intravaginal disinfectant (Microbicide) that is an intravaginal suppository for protection.

  In the past, as a means to prevent the spotted mosquitoes that carry malaria, dengue fever, Japanese encephalitis, and yellow fever (hereinafter, abbreviated as malaria), the human body is stung from a spotted mosquito with a bed of mosquito nets. It is the current situation that is defending.

  In addition, it is said that sleeping sickness infects 400,000 people every year in Central Africa and 60,000 people die. This sleepiness is caused by infection with the parasite Trypanosoma protozoa mediated by the blood-sucking fly flies. Beyond humans, farming cattle and horses are infected with sleepy mildew and die, dying, so farming is not possible, so crops cannot be taken, causing the region to escape from poverty. ing.

  Furthermore, as a means of treating malaria, there is no therapeutic effect because resistant malaria parasites have emerged for conventional quinine, chloroquine, artesunate, artemisinin and other special drugs.

  At present, there is no therapeutic means for fundamentally treating infectious diseases such as AIDS virus (HIV), hepatitis C virus (HCV), and influenza virus.

  Furthermore, there is currently no therapeutic means to protect against infections that are infected by sexual acts such as AIDS virus (HIV), hepatitis C virus (HCV), papilloma virus (HPV), vaginal chlamydia, and syphilis, and protective means to protect it. is the current situation.

  By using electromagnetic waves to kill the mosquitoes that transmit malaria parasites in the human body in the air or by heating and killing the mosquitoes that are stationary, the mosquito net is used to stab the human body from the mosquitoes. As an alternative to protecting the bed with a bed, the need for a mosquito net is eliminated by heating and killing the mosquitoes that are stationary or using the electromagnetic waves in the air.

  In addition, the fly flies that mediate sleepiness are clinging to the surface of the cow and horse skin for farming, so that the output electromagnetic waves within the range that does not kill the cow and horse are transmitted to the surface of the cow and horse skin. Agricultural cattle and horses are used by killing, using electromagnetic waves, the fly fly that mediates the trypanosoma protozoa that are responsible for the bedridden disease that causes cattle and horses to infect both cattle and horses. You will be able to cultivate the vast uncultivated farmland in central Africa.

  In addition, it provides a means of treating AIDS patients caused by AIDS virus (HIV), which is infected by over 28 million people worldwide.

  In addition, an intravaginal bactericidal agent (Microbide) is provided as a defense means to protect and prevent AIDS virus (HIV) infected by over 3 million people per year at the stage of sexual activity.

  Furthermore, it provides a means of treatment for patients infected with hepatitis C virus, which has over 2 million infected individuals in Japan alone.

  In addition, a means for sterilizing and killing influenza viruses in the air using electromagnetic waves is provided. For example, a means for sterilizing and killing avian influenza viruses such as H5N1 infecting highly virulent chickens that infect chickens inside poultry houses is provided.

  Furthermore, it exists in the air of living space where people live, for example, air inside public buildings, air inside trains, and air inside the house, for example, sterilizing influenza viruses using electromagnetic waves. And provide a means of killing.

  In order to achieve the above-mentioned object, the configuration of the present invention includes an electromagnetic wave oscillated using a magnetron as an oscillation source, a surface wave vibration, a pulse wavelength, and a solid vibration (hereinafter referred to as a crystal resonator for short). The amplified electromagnetic waves are emitted and irradiated in the air, and the mosquitoes or swallows that are intended to be killed using the electromagnetic waves are heated and killed in the air or on the surface of the cow's horse skin. I will do it.

  In addition, the name of the disease infected with malaria parasite or trypanosoma protozoa is malaria, or as a means of treating sleepiness, as a means of treating human blood or bovine horse blood, it has a strong anti-oxidation effect, and it contains proteins, chain sugars, and lipids. The catechin, which is easy to bind and has antiviral effect, is directly administered intravenously or intraperitoneally, and the name of the disease in which the human body and the cow are infected is considered to be a treatment for malaria or sleepiness. .

  Furthermore, for protozoa such as malaria parasites, mouse Costaria schistosomiasis, Trypanosoma protozoa, and Sperocheta paridae, such as protozoa, bacteria (hereinafter abbreviated as malaria protozoa or trypanosoma protozoa), Resistant malaria parasites have emerged against drugs such as quinine, chloroquine, ascofuranone, and artemisinin (hereinafter abbreviated as artemisinin) that have been developed as a specific medicine. As a treatment method for this resistant malaria parasite, catechin and artemisinin, or catechin and quinine, or catechin and chloroquine were chemically bound by mixing and using catechin and artemisinin together. By making a catechin and artemisinin, or a catechin and quinine, or a catechin and chloroquine mixed drug, the catechin and artemisinin mixed drug becomes an artemisinin derivative property. Even if Artesunate (Artesunate) and catechin, or Dihydroartemisinin (dihydroartemisinin) and catechin, or Artemether and catechin, which are friends of artemisinin, are mixed, the properties of artesunate derivatives are obtained. Alternatively, when dihydroartemisinin and catechin are mixed, the properties of the dihydroartemisinin derivative are obtained. Alternatively, when Artemeter and catechin are mixed, the properties of Artemeter derivatives are obtained. Alternatively, when quinine and catechin are mixed, the properties of the quinine derivative are obtained. Or, when chloroquine and catechin are mixed, it becomes a drug effective against resistant parasites such as resistant malaria parasites or resistant trypanosoma protozoa by causing properties of chloroquine derivatives. The name of the disease that develops can be used as a treatment for malaria or sleepiness.

  In addition, AIDS patients infected with AIDS virus (HIV), hepatitis C virus infected with hepatitis C virus (HCV), or infected with highly toxic influenza viruses such as H5N1 Antiviral activity is strong because it contains a large amount of OH groups and viruses in blood such as influenza patients (hereinafter referred to as AIDS patients), various viruses, or tuberculosis bacteria, or Intravenous administration of catechins that easily bind chemically to proteins, chain sugars, and lipids that make up cancer cells and that have antiviral, antibacterial, or anticancer effects directly into the veins of the human body To treat as an AIDS patient, hepatitis C patient, influenza patient, tuberculosis patient, or cancer patient.

  Furthermore, papillomavirus (HPV) is the causative virus of cervical cancer in which more than 3 million people are infected by sexual activity per year, or one in three young adult women. Or inactivating bacteria, such as vaginal chlamydia, that cause inflammation inside the trumpet tube, which is the fallopian tube that is infected by one in four young adult women, inside the woman's vagina, Or, for the purpose of sterilization, prevention or defense, vaginal disinfectant which is a vaginal suppository using catechin and hard hat oil or palm oil (hereinafter abbreviated as palm oil) as main raw materials (Microbicide) is formed and provided as a therapeutic means for the above infection.

  In addition, catechin has a strong effect of killing male sperm by chemically binding to male sperm proteins, chain sugars and lipids, so it can be used by inserting into the vagina from a woman's stand. When a drug is inserted into a woman's vagina in a solid state at room temperature using catechin and hard hat oil or coconut oil (hereinafter abbreviated as coconut oil) as the main raw materials, Contraception by forming a contraceptive that is an intravaginal suppository, e.g. jelly-shaped, or tablet-shaped, or rocket-shaped, which melts at a body temperature inside the vagina, e.g. Infectious diseases such as AIDS virus (HIV), hepatitis C virus (HCV), papilloma virus (HPV), vaginal chlamydia, and syphilis described above are also prevented at the stage of sexual activity, and To the control, and to provide a contraceptive which was characterized by that that can be done contraception at the same time.

  The range that does not affect the human body and the cows in the region from around 2 GHz to around 10 GHz using the oscillation source magnetron, surface wave vibration, pulse wavelength, and solid vibration (hereinafter abbreviated as crystal resonator). An EM mosquito flying in the air by emitting and irradiating the electromagnetic wave amplified by oscillating the electromagnetic wave of the output from the quartz resonator as an oscillation source in the air or on the surface of the cow's body skin, Alternatively, the surface of the bovine horse's body skin is irradiated with microwaves, which are electromagnetic waves, to heat an anopheles mosquito, or a fly fly, and to heat the protein that constitutes the anopheles mosquito, or the fly fly, from 60 ° C to 65 ° C or more. Then, by denaturing the protein that constitutes the spotted mosquito or the fly fly, the spotted mosquito or the fly fly that mediates the malaria parasite or trypanosoma protozoa And it is configured to kill in the air.

  The crystal was processed using the crystal resonator processing means described in US Pat. No. 6,952,074B2, which describes the processing means invented and discovered by Yoshiaki Nagaura of the present inventor. Emitting and radiating electromagnetic waves with increased output by amplifying electromagnetic waves using a crystal oscillator, which is a solid oscillator capable of oscillating sinusoidal electromagnetic waves, in the air or on the surface of the cow's body skin The mosquitoes that fly in the air or the fly fly are heated and killed in the air using microwaves that are electromagnetic waves, and killed.

  It can be said that a human and a cow and horse are overwhelmingly heavy in the weight ratio at the time of comparing a human and a cow and horse with a mosquito, a fly fly, or an influenza virus by mass. Using this difference in weight ratio, the output of electromagnetic waves within a range that does not affect humans and cattle and horses, mosquitoes that transmit malaria parasites using time, or fly flies that transmit trypanosoma protozoa Alternatively, the influenza virus is killed using microwaves that are electromagnetic waves.

  Carnivorous Koshimagengoro, Anopheles mosquito, bee, housefly, yellow fly, and fly fly, whose body length is around 10 mm, has a microwave frequency of around 2.2 GHz and an output of 500 W of electromagnetic wave density. In this case, it is killed in a heating time of about 20 seconds. Further, in the case of an electromagnetic wave having an electromagnetic wave density of about 2.2 GHz and an output of 900 W, it is killed in a heating time of about 10 seconds. Furthermore, in the case of an electromagnetic wave having an electromagnetic wave density of about 2.2 GHz and an output of about 1.5 KW, it is killed in a heating time of about 5 seconds. For this reason, a household microwave oven manufactured using a magtron oscillator as an oscillation source has been improved to have a structure in which the door of the household microwave oven is removed, for example, 500 W using an improved household microwave oven, Uses an improved household microwave oven designed to emit or irradiate microwaves, which are 900 W or 1.5 KW electromagnetic waves, into the air, and transmits malaria parasites that cause malaria. It is assumed that the mosquitoes can be killed in the air with the mosquitoes flying in the air. In addition, it is possible to kill the fly fly in the air while the fly fly that mediates the trypanosoma protozoa causing the sleepiness disease is flying in the air.

  In addition, for example, the output of the improved household microwave oven described above is used to emit electromagnetic waves into the air using the improved household microwave oven of 500 W, 900 W, or 1.5 KW, for example. Or, use an improved household microwave oven with a structure that can be irradiated to raise chickens. Use an improved household microwave oven to cycle electromagnetic waves into the air inside the chicken house. In particular, for example, a strong poison in which chickens become infected by emitting electromagnetic waves into the poultry house or irradiating electromagnetic waves for 5 seconds, 10 seconds, or around 20 seconds at a rate of once every 10 minutes. Microwaves that are always electromagnetic waves inside a poultry house by denaturing and degrading proteins, chain sugars, and lipids that form influenza viruses such as the H5N1 type by heating to 60 ° C or higher. To sterilize the inside of the house and to be able to kill the influenza virus using.

  Furthermore, as described above, for example, mosquitoes, fleas, lice, mites, and the like, inside a house using a modified household microwave oven, or inside a public building, or inside a building, or inside a train, and For the purpose of sterilizing and killing influenza viruses, microwaves, which are electromagnetic waves, are emitted and irradiated inside a house using an improved household microwave oven.

  Also, as described above, for example, inside the house that emits and irradiates microwaves that are electromagnetic waves of an improved household microwave oven, circulate the air inside the house and exist in the house It will be used as an air purifier that sterilizes and kills the influenza virus. In addition, the interior of an improved household microwave oven that can emit and radiate electromagnetic waves as an air cleaner such as air inside a public building, or air inside a building, or air inside a train, As described above, air is circulated to kill and kill the influenza virus present in the air.

  Polyphenon 70S, manufactured and sold by Mitsui Norin Co., Ltd., headquartered in Tokyo, and Sunphenon BG-3, manufactured and sold by Taiyo Kagaku Co., Ltd., headquartered in Yokkaichi, Mie Prefecture, are the adjusted concentrations. When (mg / ml) is 500, it has good solubility through a PTFE 0.45 μm filter, so it is administered intravenously or intraperitoneally, and the disease name is malaria, sleepiness disease, resistant syphilis, AIDS, It can be used as a therapeutic means for infectious diseases such as hepatitis C, adult leukemia, and influenza.

  Further, as described above, catechin and chloroquine, catechin and artemisinin (hereinafter abbreviated as artesunate), catechin and quinine, or catechin and AIDS therapeutic nucleic acid reverse transcriptase inhibitor, or catechin And protease inhibitors of catechins and non-nucleic acid reverse transcriptase inhibitors, or catechin and non-nucleoside reverse transcriptase inhibitors (hereinafter abbreviated as malaria or AIDS drugs) When catechin is mixed with catechin, etc., chloroquine, which is a therapeutic agent for malaria, or artemisinin, or quinine, or a nucleic acid-based reverse transcriptase inhibitor, which is a therapeutic agent for AIDS, or a protease inhibitor, or a non-nucleic acid-based reverse transcriptase inhibitor, Or chain sugars, lipids, or proteins that constitute non-nucleoside reverse transcriptase inhibitors The property of configuring and has OH groups is catechin derivatives by chemical bonds to. In particular, catechin has a strong property of chemically binding to proteins. As described above, a combination of artesunate and catechin, which are antimalarial drugs, a combination of chloroquine and catechin, a mixture of artesunate and catechin, a mixture of chloroquine and catechin, or a mixture of AIDS drug and catechin, (For short, a catechin derivative or a catechin complex) is administered intravenously into the human blood, administered intramuscularly, administered intraperitoneally, or administered intravenously Or by oral administration, the names of diseases such as malaria, sleepiness disease, AIDS, hepatitis C, adult leukemia, dengue fever, and highly toxic H5N1 influenza (hereinafter abbreviated as infectious disease), etc. Malaria parasites, trypanosoma protozoa, AIDS virus (HIV), hepatitis C virus (HCV), and influenza The Enza virus and be a therapeutic means that are intended to be a killing using catechin derivative at the blood.

effect

  Figure 1 shows the collaboration between Mitsuko Norin Co., Ltd., in collaboration with Mr. Kumiko Shintama, who was enrolled in the Master's program of Okayama University Pharmaceutical Information Sciences, and the inventor Yoshiaki Nagaura. The product name with a total content of catechins of 80.7% is polyphenone 70S, and on January 15, 2008, against the FCR-3 strain (Plasmodium Falciparum) that is a member of the malaria parasite It is an experimental result of antimalarial activity evaluation.

  Figure 2 shows the names of products manufactured and sold by Mitsui Norin Co., Ltd., described above, jointly by Kumiko Shintama and the inventor Yoshiaki Nagaura. A product name of 96.7% of total catechin produced and sold by Polyphenon 70S and Taiyo Kagaku Co., Ltd. uses Sanphenon EGCg on March 15, 2008. It is an experimental result of antimalarial activity evaluation with respect to FCR-3 strain | stump | stock (Plasmodium falciparum) (henceforth abbreviated as a malaria protozoa) which is a friend of No.1.

  Considering the experimental results described in FIG. 1 and FIG. 2, the experimental results shown in FIG. 1 and the experimental results shown in FIG. However, the trade name of 80.7% of the total content of catechins manufactured and sold by Mitsui Norin Co., Ltd. is Polyphenon 70S, and the total content of catechins manufactured and sold by Taiyo Chemical Co., Ltd. is 96. 7% of the trade names were the results of an experiment that proved that both polyphenone 70S and sunphenone EGCg, which are products of two companies of Sanphenon EGCg, have antimalarial activity against malaria parasites.

  As for the evaluation of the antimalarial activity of catechins shown in FIG. 1 and FIG. 2 above, when compared with conventional quinine, quinine, chloroquine, and artemisinin, which are specific medicines for malaria parasites, The antimalarial activity against Plasmodium was an experimental result that can be said to be an order of magnitude lower. However, quinine, chloroquine, and artemisinin, which are specific medicines for malaria parasites, are highly toxic and have side effects, whereas catechin has no toxicity and no side effects. Therefore, there is an advantage that a problem does not occur even if an amount of one digit or more is used as a therapeutic means, compared to conventional quinine, chloroquine, and artemisinin.

  In addition, as shown in the analysis value of Polyphenon 70S manufactured and sold by Mitsui Norin Co., Ltd. and the analysis value of Sunphenon EGCg manufactured and sold by Taiyo Chemical Co., Ltd., catechin is extracted from natural tea. For example, epigallocatechin (EGC), epicatechin (EC), gallocatechin (GC), catechin (C), epigallocatechin gallate (EGCg), epicatechin gallate (ECg), gallo Since catechin gallate (GCg) and catechin gallate (Cg) contain a total of 8 different catechins, resistant malaria, resistant AIDS virus (HIV), resistant hepatitis C virus (HCV), resistant influenza virus There is an advantage that resistant chlamydia and resistant syphilis cannot be made.

Further, the analysis values shown below are analysis values of Polyphenon 70S manufactured and sold by Mitsui Norin Co., Ltd.

The analysis values shown below are those of Sanphenon EGCg manufactured and sold by Taiyo Chemical Co., Ltd.

Also shown below are 4 of Polyphenon 70S manufactured and sold by Mitsui Norin Co., Ltd., Sanphenon BG-3 manufactured and sold by Taiyo Chemical Co., Ltd., Sunphenon 90S, and Sanphenon EGCg. It is the test result which tested whether the kind can be intravenously administered by Shin Nihon Kagaku Co., Ltd. According to the following test results, it was found that two types of polyphenone 70S and sunphenon BG-3 were highly soluble and passed through a 0.45 μm filter made of PTFE, so that intravenous administration was possible. In particular, two types of polyphenone 70S and sunphenon BG-3 are test results that have been found to be highly soluble and can be administered intravenously.

Further, what is shown below is a test result of a solubility test of Sanphenon EGCg, which was requested to Shin Nihon Kagaku Co., Ltd., also explained above. Sanphenone EGCg is a test result that proved to be unsuitable for intravenous administration due to its low solubility.

Further, the analysis values shown below are those of Sanphenon BG-3 manufactured and sold by Taiyo Kagaku Co., Ltd.

The analysis values shown below are analysis values of Sunphenon 90S manufactured and sold by Taiyo Chemical Co., Ltd.

  Furthermore, it is possible to judge from the results of the four types of solubility tests described above, Polyphenon 70S, Sunphenon BG-3, Sunphenon 90S, and Sunphenon EGCg, which were requested from Shin Nihon Kagaku Co., Ltd. It has been found that when the content of epigallocatechin gallate (EGCg) is 52.2% or more of the total catechin content, the solubility in an aqueous solution becomes poor. It was also found that the solubility in an aqueous solution was poor when the content of caffeine was large. From this, when intravenous administration, the ratio of epigallocatechin (EGCg) to total catechin content of 52.2% or less of catechin content is found to be optimal for intravenous administration Did. For example, polyphenone 70S with an epigallocatechin gallate (EGCg) content of 32.2% and sanphenone BG-3 with an epigallocatechin gallate (EGCg) content of 41.7% are available for intravenous administration. It was a test result of a test that can be judged to be optimal.

  In addition, as described above, polyphenone CG or sunphenone 90S is the total catechin content, and polyphenone CG is caffeine as shown in the report of the catechin analysis result (HPLC method) of [0045]. Is contained in an amount of 5.4%. Sunphenon 90S contains 5.0% of caffeine as shown in the report of the analysis value example of Sunphenon 90S in [0043]. A report regarding the solubility of this polyphenone CG and sunphenon 90S, polyphenone 70S, and sunphenon BG-3 in four types of physiological saline or aqueous solution is shown in [0040]. As described in a report from Shin Nihon Kagaku Co., Ltd., the adjusted concentration of both polyphenone CG and sunphenon 90S is 125 mg / ml, whereas polyphenone 70S and sunphenone containing no caffeine at all. From Shin Nihon Kagaku Co., Ltd., a report that BG-3 is dissolved in a physiological saline with an adjusted concentration of 500 mg / ml or an aqueous solution (hereinafter abbreviated as water for injection) is described in [0040]. This is a report. It can be judged from this report that, when various catechins are administered intravenously, various catechins that do not contain caffeine at all are better soluble. Therefore, when various catechins are administered intravenously, intravenous administration of various catechins not containing caffeine at all may be a necessary condition for intravenous administration of various catechins. The results of the tests on the solubility of various catechins requested by Shin Nihon Kagaku Co., Ltd. were revealed.

  Furthermore, 11 types of catechins shown in Table 1 below are catechin reagents having a purity of 98% or more, which are manufactured and sold by Nagara Science Co., Ltd., headquartered in Gifu City. The catechin having a purity of 98% or more is a hydrophobic property in a white crystalline state that does not dissolve in an aqueous solution. It has the property of dissolving only in methanol, methyl alcohol, ethanol, or ethyl alcohol (hereinafter abbreviated as methanol). Therefore, in order to administer catechin intravenously, the catechin must be dissolved in an aqueous solution so that it is necessary to use a catechin whose concentration is reduced to 98% or less. As a method for diluting catechin having a purity of 98% or more by dissolving it in an aqueous solution, for example, after purifying catechin in the crystalline state having the concentration of catechins of 98% or more shown below as shown in FIG. And then diluting with an aqueous solution, and then removing the toxic methanol by heating or using other means, the purity of the catechin containing 98% or more catechin is obtained. An aqueous solution having an arbitrary concentration can be adjusted. For example, even if the concentration of catechin is 50% or less or 60% or less, the concentration of catechin can be freely adjusted to any concentration, so the following (1), (2), (3), There are the effects 4) and 5).

  As an advantage of (1), since catechin having a purity of 98% or higher is used, the amount of impurities is small.

  As an advantage of (2), since the catechin having a purity of 98% or more is used, since it is a colorless and transparent aqueous solution, toxicity can be removed without limit.

  Advantages of (3) are the effects of catechins such as antibacterial effects such as tuberculosis of 11 types of catechins shown below, anticancer effects, antiviral effects, antimalarial protozoan effects, and antitrypanosome protozoan effects. Therefore, it is easy to obtain an evaluation as a pharmaceutical because a highly accurate therapeutic effect can be obtained.

Shown below is Table 1 described above.

  The advantage of (4) is that catechins having a purity of 98% or higher can be adjusted, and catechins having an arbitrary concentration of catechin can be adjusted. Therefore, PTFE filters or PVDF 0.45 μm For example, the concentration of catechin can be adjusted to 500 (mg / ml) with a concentration of catechin of 40% or less.

  The advantage of (5) is that catechin having a purity of 98% or higher is dissolved in methanol, and then catechin and hard hat oil or coconut oil (hereinafter abbreviated as coconut) dissolved in methanol. After mixing the oil, the methanol used as the solvent used to dissolve the catechin having a purity of 98% or more was heated, or the methanol was removed using other means. Catechin and vaginal disinfectant (Microbicide), which is an intravaginal suppository made mainly of palm oil, or a vaginal disinfectant that also functions as a contraceptive to be inserted into the vagina are colorless and transparent white, so clothing There is an advantage that does not pollute. The conventional catechin is not a single product but a mixture of several types of catechins and the purity is low, so the color of conventional catechins is brown or black. There is a fault that colors and stains the color.

  In addition, when a drug such as catechin and chloroquine, catechin and artemisinin, or catechin and quinine described above is mixed at a certain ratio, a combination of catechin and chloroquine, or catechin and artemisinin, or catechin and quinine The body catechin derivative is completed. The characteristics of this catechin derivative are that, unlike catechin alone, the catechin derivative is absorbed in the human intestinal tract without being decomposed in the stomach and intestinal tract, which are the digestive organs of the human body. Although it can be administered internally, it is optimal for oral administration. Moreover, since this catechin derivative is a mixture of several types of catechins, or 8 types of catechins and chloroquine, artemisinin, and quinine, there is an advantage that resistant malaria parasites, resistant trypanosoma protozoa, or resistant AIDS virus cannot be produced.

Furthermore, the nucleic acid reverse transcriptase inhibitors of catechins and AIDS drugs as described above, retrovir, zidovudine, AZT, videx, didanosine, ddI, hibid, ddC, epivir, lamivudine, 3TC, jelly, stavudine , D4T, combivir, ziagen, and abacavir sulfate, or the AIDS therapeutic drugs clixiban, novia, ritonavir, biraccept, mesylate, nelfinavir, prose, amprenavir, fort base, saquinavir, caretola, lopinavir, and ritonavir, or non-nucleic acid Systemic reverse transcriptase inhibitors viramune, nevirapine, stockrin, efavirenz, rescriptor, delavirdine mesylate, or non-nucleoside reverse transcriptase inhibitor nevirabin mixed with catechin As the drug active against causing the resistance AIDS virus is the academic bond. Table 2 below shows the names and product names of manufacturers of AIDS drugs.

  In addition, when catechin is administered intravenously or orally, particularly when catechin is administered orally, the 11 types of catechins described in [0051] above or manufactured by Mitsui Norin Co., Ltd. Conventional types of catechins (hereinafter abbreviated, such as Polyphenon 70S and Polyphenon CG that are sold, or Sunphenon BG-3, Sunphenon 90S, and Sunphenon EGCg that are manufactured and sold by Taiyo Kagaku Co., Ltd.) In the case of oral administration of various catechins, or catechins, or catechins, intravenous administration, intramuscular administration, intraperitoneal administration, and intravenous administration (hereinafter abbreviated as intravenous administration) The catechins are decomposed in the digestive organs of the human body, such as the stomach or the small intestine and are not easily absorbed by the intestinal tract. Because there is a point, various catechins also absorption rate in the digestive tract by the oral administration there is a very bad disadvantages. The various catechins having a poor absorption rate in the digestive organs of various conventional catechins have a certain ratio, for example, 10% of various catechins by weight ratio of 9 and caffeine of 1: 9 or less of 1: 9. The following ratio, or the ratio of various catechins is 8, and the ratio of caffeine is 2:20 or less of 2: 8 or less, or the ratio of various catechins is 7, and the ratio of caffeine is 3: 3 or less of 3: 7 or less of 30% or less. The ratio, or various catechins is 6, and the ratio of caffeine is 4 or less of 4: 6 or 40% or less, or the various catechins is 5 and the ratio of caffeine is 5 or 5: 5 or less of 50% or less, Or, the ratio of various catechins is 4, and the ratio of caffeine is 6: 4 or less of 60% or less, or the ratio of various catechins is 3, and the ratio of caffeine is 7: 3 or less of 7: 3 or less, or various ratios 80% of catechins are 2 and caffeine is 8: 2 or less of 8 Various catechins (hereinafter, abbreviated as follows), or various catechins mixed with caffeine mixed in various catechins at a ratio of 1 and 90% or less of 9: 1 or less of 9: 1. When various catechins containing caffeine or catechin derivatives are orally administered, various catechins have a property of being chemically chemically bonded to caffeine. The effects of various catechins containing caffeine obtained by chemically bonding these various catechins and caffeine are as follows: (1), (2), (3), (4), (5), (6), There are effects such as 7 ▼, 8), 9), 10), 11), 12), 13), 14), 15), and 16).

  As an effect of (1), as an advantage of various catechins containing caffeine, it has a property that it is difficult to be decomposed in the stomach or small intestine, which is the digestive organ of the human body, or a property that is not decomposed in the digestive organ.

  As an effect of (2), as an advantage of various catechins containing caffeine, it is easily absorbed into human blood in the intestinal tract which is the digestive organ of the human body.

  (3) The effect of various catechins containing caffeine is that it is efficiently absorbed into the blood in the intestinal tract, the digestive organ of the human body, so the disease name is malaria, sleepiness, AIDS, type C It can be used as a drug for therapeutic means such as hepatitis, influenza, chlamydia, ringworm, vesicularis, tuberculosis, and cancer cells. Moreover, the effect as a chemical | medical agent has the effect as a chemical | medical agent similar to various conventional catechins. However, the solubility in physiological saline or aqueous solution deteriorates in proportion to the content of caffeine, so it cannot be used for intravenous administration or should be used for intravenous administration. It becomes difficult to do. However, if the caffeine content is 5% or less with respect to the total weight of the total catechin contents of various catechins, the solubility in physiological saline or an aqueous solution may deteriorate. But somehow intravenous administration is possible. However, it can be said that the content of caffeine is 5% or more with respect to the total weight of the total catechin content.

  (4) The effect of each catechin containing caffeine for the purpose of oral administration is that it can be easily applied to infants or adults in the syrup state, capsule state, or tablet state. Can be drunk.

  (5) The effect of each catechin containing caffeine administered orally is that it is absorbed in the human blood in the intestinal tract, which is the digestive organ, and then easily decomposed in the human liver. Is done.

  As an effect of (6), the content of caffeine with respect to the weight ratio of the total catechin content of natural tea catechins is, for example, the analysis of Sunphenon 90S of Taiyo Kagaku Co., Ltd. shown in [0043]. As shown in the values, 5.0% of caffeine is contained with respect to the total weight of the total catechin content. In addition, as shown in the catechin analysis result (HPLC method) of polyphenone CG of Mitsui Norin Co., Ltd. shown in [0045], 5.4% of caffeine is added to the total content of the total catechin content. The inclusion is the reason why it is difficult to decompose in the intestinal tract, which is the digestive organ of the human body. It is also the reason why it is easily absorbed in the intestinal tract. Furthermore, it is also a reason why it is easily decomposed in an organ such as a human liver.

  As described in (7) above, as described above, when administered orally, 5% or more of caffeine is added to the total weight of the total catechin content relative to the total weight of the total catechin content. On the other hand, when caffeine is mixed, it becomes more difficult to be decomposed in the intestinal tract, which is a digestive organ. Further, it is easily absorbed in the intestinal tract. Furthermore, since it is easily decomposed by the liver of the human body, the effect as a medicinal effect is further enhanced.

  As the effect of (8), as described above, the content of caffeine with respect to the total catechin content of various catechins, for example, polyphenone CG having a caffeine content of 5.4%, Solubility in physiological saline or aqueous solution when caffeine content is 5%, and physiological saline or aqueous solution of polyphenone 70S and sunphenone BG-3 not containing caffeine at all [0040] The experimental results of the solubility experiment conducted by requesting Shin Nihon Kagaku Co., Ltd. to conduct an experiment comparing the solubility of these compounds in [N] is shown. According to a report of the experimental results, it was found that polyphenone 70S and sunphenone BG-3, which do not contain caffeine at all, have good solubility. It was also found that polyphenone CG and sunphenone 90S containing caffeine have poor solubility.

  As an effect of (9), the solubility of Sunphenon EGCg manufactured and sold by Taiyo Kagaku Co., Ltd. shown in the above [0039] using physiological saline or aqueous solution is [0041] A report of the results of an experiment conducted on the solubility of Sanphenon EGCg by requesting Japanese science is shown in [0041]. It can be judged from the report of the experimental results shown in this [0041] that the dissolution of sunphenone EGCg whose content of epigallocatechin gallate (EGCg) is 92.7% of the total catechin content It turns out that the nature is bad. From this, the physiological saline of polyphenone 70S having a low epigallocatechin gallate (EGCg) content of 32.3% and sanphenone BG-3 having a low epigallocatechin gallate (EGCg) content of 41.7% Or the solubility in aqueous solutions was found to be good. From the above, when various catechins are administered intravenously, the content of epigallocatechin gallate (EGCg) is 41.7% or less or 92.3% by weight with respect to the total catechin content of various catechins. Various catechins containing 7% or less epigallocatechin gallate (EGCg) have been found to be optimal when administered intravenously.

  As the effect of (10), the antiviral activity or the anti-malarial protozoan activity increases as the content of epigallocatechin gallate (EGCg) increases with respect to the total catechin content of various catechins described above. Antioxidant effects such as antitrypanosoma protozoan activity, bacteria or tuberculosis killing effects, or anticancer effects, the stronger the epigallocatechin gallate (EGCg) content, the stronger the antioxidant effect That is clear. However, as explained above, Sunphenon EGCg manufactured and sold by Taiyo Kagaku Co., Ltd., which has a large content of epigallocatechin gallate (EGCg), has a content of epigallocatechin gallate (EGCg). Since the content is as high as 92.7% with respect to the total catechin content of various catechins, there is a drawback that it cannot be administered intravenously because of poor solubility that does not dissolve in physiological saline or aqueous solution. The content of epigallocatechin gallate (EGCg) contained in the total catechin content of various catechins as a means of avoiding the drawback of poor solubility as the content of epigallocatechin gallate (EGCg) increases. It has been found that the solubility of a physiological saline solution or an aqueous solution intended for intravenous administration is improved by lowering the pH.

  As the effect of (11), since various catechins described above are characterized by high reactivity with substances containing iron or iron (hereinafter abbreviated as iron), various catechins Is administered orally or intravenously, various catechins containing iron obtained by chemically reacting various catechins and iron to form chemical bonds (hereinafter abbreviated as various catechins containing iron, Or catechin derivatives) orally or intravenously, various catechins containing iron that are chemically bound to iron are decomposed in the digestive organs of the human body, such as the stomach and small intestine. Since various catechins containing iron are absorbed in the intestinal tract, they can be used as a treatment method for various infectious diseases described above.

  As an effect of (12), as a means of treating agricultural cattle infected with trypanosoma, a parasite borne by the fly fly, which is the cause of the infectious disease with the name of the disease, and domestic animals such as horses or pigs The catechins or catechin derivatives described above are administered orally, intraperitoneally, or administered intravenously, such as farming cattle, horses, and pigs. The name of the illness is used as a means of treating sleepiness when livestock is infected.

  The effect of (13) is that, as described above, various catechins are orally administered intraperitoneally, intraperitoneally, or intravenously, so that the name of the disease is influenza. However, Japanese encephalitis, dengue fever, and yellow fever can eradicate viruses that are strains of the coronavirus, a porcine-derived virus from which pigs are the source of infection. This swine-derived influenza virus, dengue fever, yellow fever, and Japanese encephalitis virus that develops mosquitoes that are mosquitoes are transmitted to humans and birds, etc., the disease name is influenza, dengue fever Yes, yellow fever, Japanese encephalitis. From this, the disease name is influenza, dengue fever, yellow fever, Japanese encephalitis (hereinafter referred to as influenza for short) is also a coronavirus companion that swine is a carrier, so the disease name eradicates influenza If eradicating swine-derived flu from the body of a pig that is a carrier, the name of the disease can eradicate the flu. In addition, the disease names Dengue, Yellow Fever, and Japanese Encephalitis can be eradicated just like influenza. In order to eradicate the virus that is a member of the coronavirus derived from pigs from the body of the pig, various catechins and catechin derivatives (hereinafter referred to as catechins) described above are incorporated into the pig body. For example, by oral administration, which is a therapeutic means for feeding catechin from the mouth of pigs, or by intraperitoneal administration, or intravenous administration, from the earth, it is a companion of coronaviruses derived from pigs. It is possible to eradicate viral diseases such as influenza, avian influenza, dengue fever, yellow fever, and Japanese encephalitis.

  As an effect of (14), catechin is administered orally, intraperitoneally, or intravenously, so that it can be prevented in patients with resistant M. tuberculosis that develops due to M. tuberculosis, which is the pathogen of M. tuberculosis. As a therapeutic means, catechin is administered orally, intraperitoneally, or intravenously to be a therapeutic means for patients with resistant M. tuberculosis.

(15) As an effect of catechin administered orally, intraperitoneally, or intravenously, cancer cells floating in the blood are treated with cancer cells using the anticancer effect of catechin. As a therapeutic means aiming to kill cancer cells and prevent metastasis of cancer cells in the blood, catechin is used as a therapeutic means for cancer patients by oral administration, intraperitoneal administration, or intravenous administration.

  As an effect of (16), catechin chemically and covalently binds to proteins, chain sugars, and lipids constituting male semen. By using this phenomenon, a contraceptive for the purpose of contraception intended to inactivate semen in the woman's vagina, when the woman is in the position of a woman, the main ingredients are catechin and hard hat oil, or catechin With palm oil as the main raw material, it has the effect of forming a contraceptive that women can use inside the vagina.

  In addition, Table 3 shown below is manufactured and sold by Associate Professor Akira Ishii in the Department of Infectious Diseases of Hamamatsu Medical University, Taiyo Kagaku Co., Ltd., located in 1-3-1 Takaramachi, Yokkaichi, Mie Prefecture. The product name is Sanphenon BG-3 ([0042] shows an example of the catechin composition of Sanphenon BG-3) and Mitsui Norin Co., Ltd. is located in 1-2-9 Nishishinbashi, Minato-ku, Tokyo. Two types of catechins (hereinafter abbreviated as catechins) of polyphenone 70S manufactured and sold ([0038] shows the results of catechin analysis of polyphenone 70S (HPLC method)) are used. Table 3 below shows the experimental results for anti-malaria using mice that were requested to conduct an anti-malarial effect on malaria parasites infected by mice.

  In addition, a report of experimental results from Associate Professor Akira Ishii to the inventor, Yoshiaki Nagaura, below, and two types of catechins, Sanphenon BG-3 and Polyphenon 70S described above in Table 3 below, are used. The experimental result of antimalarial action is shown.

  Also shown below is a report from Associate Professor Akira Ishii to the inventor Yoshiaki Nagaura, explained above.

Furthermore, Table 3 shown below is an experimental result of the antimalarial action of catechins requested to Associate Professor Akira Ishii explained above.

The experimental results of the experiment using the mouse shown in Table 5 above will be described below.
When EGCg 500 mg / kg was intraperitoneally administered twice a day on the fourth day of protozoal infection, 13 of 15 mice died the next day.
When 500 mg / kg of Poly70S was intraperitoneally administered twice a day on the 4th day of protozoal infection, 9 of 15 mice died the next day.
As the experimental plan, artesunate, chloroquine and catechins were to be administered simultaneously from the fourth day of infection with Plasmodium.
However, the plan was changed because catechin 500 mg / kg x 2 / day showed more adverse effects on mice than expected and most mice died.
That is, 5 mice in the infection control group and artesunate alone and chloroquine alone administration groups were used, and catechin administration was sent for 1 day and started.
As a result, the number of mice was small and the test could not be performed, but in particular, the combined effect of artesunate and sanphenone was recognized.
If the protozoa relapses, the mouse will die when the infection rate is low. However, in the combined mice, the survival period was prolonged, and furthermore, there was no death when the infection rate was low.
From this, it is suggested that the effect becomes clearer by taking a longer administration period of sanphenone and administering it at the same time as artesunate.

  Moreover, according to the experimental result using the malaria parasite which the mouse | mouth which the mouse | mouth which infects the mouse | mouth infected as shown in Table 3 demonstrated above was demonstrated, with respect to the malaria protozoa which a mouse | mouth infects, sunphenon BG-3 (EGCg) A combination of chloron and Sanphenon BG-3 (EGCg), and a combination of Artesunate and Sanphenon BG-3 (EGCg) are effective against malaria parasites that infect mice. It turned out. In particular, Table 3 shows a report of experimental results from Associate Professor Akira Ishii that there is a possibility that a combined effect of two types of drugs, artesunate and sanphenon BG-3, has been confirmed.

  Furthermore, the results of the experiment shown in Table 3 and the results shown in FIG. 1 and FIG. 2 on January 15, 2008, which were requested by Mr. Kumiko Shintama of the Okayama University Pharmaceutical Information Science Course, The results of an in vitro antimalarial activity evaluation using FCR-3 strain (Plasmodium falciparum), a type of Plasmodium parasite, conducted on March 15, 2008, and a request from Associate Professor Akira Ishii Table 3 shows a report that the experimental results of animal experiments using in vivo mice of the malaria parasite that the infected mice are infected with are in agreement.

  In addition, it was found from the experimental results shown in Table 3 that catechin and artesunate (artesunate is a substance in which hydrophobic artemisinin is made hydrophilic and water-soluble) are antioxidant substances that generate free radicals. It is basically the same substance.

  Furthermore, it was found from the experimental results shown in Table 3 that the malaria parasite used in this experiment was resistant malaria parasite that had no effect as a drug against three kinds of drugs, quinine, chloroquine, and artesunate. I use it. As shown in the experimental results of Table 3 in which artesunate (Art) and chloroquine (CQ) alone were administered in Table 3, a combined use of artesunate (Art) and catechin (hereinafter abbreviated as catechin derivative or Ernest) A combination of chloroquine (CQ) and catechin (hereinafter abbreviated as a catechin derivative or a chloroquine derivative), and comparing artesunate (Art) and chloroquine (CQ) alone. The administration of artesunate derivatives and chloroquine derivatives, which are catechin derivatives, is more effective against resistant Plasmodium than the administration of artesunate (Art) and chloroquine (CQ) alone. The experimental results that have been found are the experimental results in Table 3.

  In addition, the artesunate derivative, which is a catechin derivative, and the chloroquine derivative are more effective for artesunate (Art) and chloroquine (CQ) than the administration of artesunate (Art) and chloroquine (CQ) alone described above. The catechin and artesunate (Art) that make up the catechin derivative, and the carboxyl that makes up the catechin and chloroquine (CQ) are more effective against the resistant malaria parasite than The group (COOH) and the hydroxyl group (OH group) cause a condensation reaction that is a chemical reaction, and catechin and artesunate (Art) are condensed. Alternatively, catechin and chloroquine (CQ) were able to generate an effect against resistant malaria parasites that have no effect as a drug.

  Furthermore, since catechin is highly reactive, a resistant malaria parasite may be inactivated by using a medicine in which three kinds of catechin, quinine, and artesunate (Art) are mixed. Or you may inactivate a resistant malaria parasite using the chemical | medical agent which mixed 4 types of catechin, artesunate (Art), chloroquine (CQ), and quinine.

  In addition, sleepy illnesses that occur in humans due to infection with Trypanosoma protozoa that carry the pathogens of the fly flies that are very similar to abu, sleep diseases that occur in humans, or wild animals, or domestic animals such as cattle, horses, goats, etc. Dr. Gakuzo Tamura of the Department of Agricultural Chemistry of the University of Tokyo, who has developed an infection with Trypanosoma protozoa, has antiviral activity from filamentous fungi, a type of mold that causes plant disease. Ascochlorin, a substance to be shown, was found in 1968. In 1972, a substance with a slightly different chemical structure was found and named ascofuranone. It was discovered by Professor Kiyoshi Kita of the Department of International Health, Graduate School of Medicine, the University of Tokyo that this ascofuranone was found to have a significant effect on sleep disease and Nagana disease. A drug in which two kinds of this ascofuranone and catechin are mixed (hereinafter abbreviated as an ascofuranone derivative or a catechin derivative), or a drug in which three kinds of ascofuranone, catechin and artesunate are mixed (hereinafter, Abbreviated ascofuranone derivative or catechin derivative), or a drug containing four kinds of ascofuranone, catechin, artesunate, and chloroquine (hereinafter abbreviated as ascofuranone derivative or catechin derivative) Or a drug containing 5 kinds of ascofuranone, catechin, artesunate, chloroquine and quinine (hereinafter abbreviated as ascofuranone derivative or catechin derivative) for the treatment of sleeping sickness and Nagana disease When used as a drug, ascofuranone alone is used to treat sleep sickness and There is avoided the effect of relative be resistant Trypanosoma protozoans when treating animal trypanosomiasis.

  Further, the ascofuranone derivative described above has a condensation reaction between the hydroxyl group constituting the ascofuranone (OH group) and the hydroxyl group constituting the catechin (OH group). Since catechin is condensed to synthesize an ascofuranone derivative, the ascofuranone derivative has a complex chemical structural formula and has an effect of avoiding the resistance to trypanosoma protozoa.

  The discovery of Trypanosoma protozoa, which causes sleep sickness, was observed in 1680 by the Dutch naturalist Lee Wenhoek, who observed a number of small animals moving around in the intestines of fountains at high speed.

  In addition, the name Trypanosoma protozoa found a parasite that Hungarian-born doctor David Grubi had never seen when he was looking at spider blood in 1843. We named it Trypanosoma because the spiral movement looked like a bottle of wine.

  In addition, India, North Africa, the Middle East, East Asia, and Latin America have a disease called Sura disease. This is caused by various animals such as horses, donkeys, cattle, and buffaloes. In the acute case, most people die unless treated. In 1880, veterinarian Griffith Evans, who worked in India, found a trypanosoma protozoa in the blood of a horse and camel with Sura disease. This pathogen is called Evans trypanosoma in the name of the discoverer.

  Furthermore, as the main vector species of fly fly, infection is caused by the species of fly fly called Brus Trypanosoma and Grossina Morcitans that infect the pathogens of Rhodesia trypanosoma. Grossina parpalis, a type of flies, infects Gambia trypanosoma pathogens.

In addition, trypanosoma protozoa are characterized by unicellular protozoa that multiply outside the cell by two divisions.
The size is 20 to 30 μm in length, the width is 1.5 to 3.5 μm, and the shape is a spindle shape. The structure has a nucleus in the center and an organ called kinetoplast (motor nucleus) near the end, which contains large DNA. From the vicinity of kinetoplasts, flagella begin and go out to the outside through holes like acupuncture called flagella pockets formed by invading the cytoplasm.

  In addition, Chagas disease is a disease caused by the infection of cruise trypanosoma and occurs throughout Latin America sub-Mexico. It is estimated that nearly 20 million people are infected. It is also called poverty, because many occur among people living in poor houses with earthen or thatched roofs. The parasite that infects pathogens is held by the nocturnal large blood-sucking insect turtle that lives in soil. Sand turtles have the habit of sucking blood while humans are sleeping at night, and then dropping feces. When a person bites a turtle and feels pain, the protozoan cruising trypanosoma invades from the mucous membrane and infects it. Another infection route is caused by blood transfusion.

  In addition, leishmaniasis is an infectious disease that is transmitted by the same Trypanosoma protozoa as the pathogens of sleep disease and Chagas disease.

  Further, the catechin alone shown in Table 3 described above (hereinafter abbreviated as catechin alone) or a combined use of catechin and artesunate (hereinafter abbreviated as catechin derivative or artesunate derivative), or The drug of combined use of chloroquine and catechin (hereinafter abbreviated as catechin derivative or chloroquine derivative) is infected with Trypanosoma protozoa, which are described above, and are carried by a fly that is similar to a fly. Due to sleep diseases that are human-onset sleep diseases, or due to trypanosoma protozoa, wild animals, or cattle, horses, goats and other domestic animals are infected with trypanosoma protozoa, and Nagana disease that develops Or India, North Africa, the Middle East, East Asia, and Latin America have a disease called Surah's disease. This surah disease also occurs in various animals such as wild animals, horses, donkeys, cattle, and buffalos. This Surah disease is also caused by Trypanosoma protozoa as well as sleep diseases. This pathogen is also caused by Trypanosoma protozoa. Chagas disease is caused by a protozoan of Trypanosoma cruzi, which is carried by sour turtles. Furthermore, leishmaniasis is an infectious disease that is transmitted by Trypanosoma protozoa. As described above, catechin alone, artesunate derivatives for sleep disease, Nagana disease, Surah disease, Chagas disease, and Leishmania disease (hereinafter abbreviated as sleep disease) that develop due to Trypanosoma protozoa, and Chloroquine derivatives have been found to have significant pharmaceutical effects.

  In addition, since Trypanosoma protozoa that develop sleep diseases caused by Trypanosoma protozoa as described above is a parasite that grows directly in the blood of the human body and animals, Trypanosoma protozoa is blood. A parasite that floats inside and grows directly in the blood. Plasmodium is a parasite that grows inside red blood cells. When these two are compared, it is very difficult to inactivate malaria parasites because they are concealed inside red blood cells, so it is very difficult to inactivate malaria parasites. This is because it has been found that it is easier to inactivate trypanosome protozoa than to inactivate malaria protozoa because it grows directly. Furthermore, since the syphilis pathogen Spirochetaparida or resistant Spirochetaparida parasite is a parasite that floats in the blood and proliferates, catechin alone, catechin that inactivates malaria parasite, just as inactivated Trypanosoma protozoa It has been found that the derivatives, artesunate derivatives, and chloroquine derivatives also have significant pharmaceutical effects on spirochete parida, which is a syphilis pathogen, or resistant spirochete parida parasite.

  Furthermore, a group of Prof. Yusuke Wataya from Okayama University Graduate School synthesized a new compound “N251” similar to the chemical structure of the existing drug artemisinin (also known as artesunate), which was developed as a treatment for malaria. By mixing and using this “N251” and catechin together, “N251” and catechin undergo a condensation reaction similar to a chemical reaction, resulting in a condensation bond. Therefore, “N251” is a new and more complicated new one. It becomes a compound and has the effect of preventing the occurrence of resistant malaria parasites. At the same time, when “N251” similar to artemisinin is used alone, “N251” similar to artemisinin and catechin are mixed. When used together, the effect as a drug such as the following (1), (2), (3), (4), and (5) is more effective.

  The effect of (1) as a drug is to inactivate various other viruses such as AIDS virus, influenza virus, papilloma virus, rotavirus, norovirus, and herpes in artemisinin-like new compound “N251” as well as artemisinin. There is an effect that can be done.

  (2) As a drug, the new compound “N251” similar to artemisinin has an anticancer effect against various miscellaneous cancer cells.

  The effect of (3) as a drug is the sleep disease that develops due to Trypanosoma protozoa mediated by the fly fly, or Nagana disease that also develops in domestic animals such as cattle, horses, goats, etc. The new artemisinin-like compound “N251” is effective for diseases such as leishmaniasis that develops due to the protozoa that mediates syphilis, or syphilis that develops due to the protozoan spirocheta paridae.

  (4) The effect as a drug is that artemisinin-like new compound “N251” and 11 types of catechins shown in (Table 1) (hereinafter abbreviated as catechin) are mixed and used together. Then, artesunate (hereinafter abbreviated as artemisinin) and artemisinate used in the experiment to inactivate malaria parasites at Hamamatsu Medical University shown in (Table 3) and catechin Similar to the experimental results mixed and used together, artemisinin-like “N251” similar to artemisinin was used alone, and artemisinin-like “N251” and catechin were combined and used together as a drug. There is an effect.

  The effect of (5) as a drug is the use of a new compound "N251" similar to artemisinin described in (1), (2) and (3) above, for AIDS virus, influenza virus, When inactivating various miscellaneous viruses such as papillomavirus, rotavirus, norovirus, and herpes, the new artemisinin-like compound “N251” is used rather than the artemisinin-like new compound “N251” alone. When combined with catechin, it is more effective as a drug. In addition, the anticancer effect described in (2) above is also obtained by mixing artemisinin-like new compound “N251” with catechin rather than using artemisinin-like new compound “N251” alone. When used together, it is more effective as a drug. Furthermore, sleep diseases that develop due to Trypanosoma protozoa mediated by the fly fly described in (3) above, or Nagaana diseases that also develop protozoa caused by Trypanosoma protozoa, or protozoa that are mediated by scabs New artemisinin-like compound “N251” is used for leishmaniasis that develops due to syphilis, or syphilis that develops due to protozoan spirocheta paridae, rather than the new artemisinin-like compound “N251” alone. The combination of catechin and catechin is more effective as a drug.

  Further, it was found from the experimental results shown in Table 3 that the mice used in the experiments shown in Table 3 are resistant to artemisinin (hereinafter referred to as artesunate) and chloroquine. Mice and chloroquine resistant mice were used in the experiments. As a result, in the same manner as ICR Non-treatment (Control) shown in Table 3 for both artesunate and chloroquine, both artesunate and chloroquine are not effective as drugs against artesunate-resistant mice and chloroquine-resistant mice. Turned out. In particular, the experimental results in Table 3 proved that artesunate has no effect on artesunate-resistant mice.

  Furthermore, it can be judged from the experimental results described in Table 3 above, that catechin is a substance that easily causes chemical reactions and condensation reactions with various proteins, sugar chains, lipids, and fatty acids. It is. In particular, catechin undergoes a condensation reaction with substances containing proteins, sugar chains, lipids, and fatty acids, and changes the composition of the partner substance that has caused the condensation reaction with catechin, so that A derivative of a substance or a complex of a partner substance (hereinafter, a derivative of a partner substance, a catechin derivative, or a catechin complex) is formed. For example, judging from the experimental results shown in Table 3, catechin and artesunate undergo a condensation reaction to cause catechin derivatives or artesunate derivatives (hereinafter abbreviated as catechin derivatives or artesunate derivatives), or catechins and chloroquine condense. By causing a reaction to form a catechin derivative or a chloroquine derivative (hereinafter abbreviated as a catechin derivative, a catechin complex, or a chloroquine derivative), the artesunate derivative or chloroquine derivative has an artesunate resistant mouse or chloroquine resistant It proved to be effective as a drug for mice.

  Moreover, what was found from the experimental results shown in Table 3 described above is that artesunate and catechin, or chloroquine and catechin are condensed by a condensation reaction, but artesunate and catechin, or chloroquine and catechin are The experimental results shown in Table 3 have revealed that the effect of the artesunate derivative or chloroquine derivative having a condensation bond by a condensation reaction as an agent can be avoided.

  Furthermore, what was found from the experimental results shown in Table 3 described above was that a drug combining catechin and chloroquine was found to be effective as a drug for chloroquine-resistant mice. However, it has a very important meaning for the following reasons (1), (2), (3), (4), and (5).

  The reason for (1) is that chloroquine, which was developed as a drug whose disease name is malaria, has some side effects but is very inexpensive.

  The reason for (2) is that the name of the disease is malaria, and 37 countries in the sub-Saharan Africa region have the highest number of malaria patients on the earth. This sub-Saharan region is also the poorest in the world. For this reason, expensive drugs cannot be used as therapeutic drugs.

  The reason for (3) is that, as a therapeutic means for treating malaria by the name of the disease, it is a therapeutic means by oral administration using tablets that are simpler and cheaper than intravenous administration using a syringe or intraperitoneal administration. When treating malaria, the most inexpensive and optimal tablet for the purpose of oral administration is a chloroquine derivative formed by condensation reaction of chloroquine and catechin as the main raw material. .

  The reason for (4) is that when catechin is administered orally in combination with chloroquine, catechin undergoes a condensation reaction when catechin is used in combination with chloroquine because catechin is easily decomposed in the small intestine of the digestive tract. Catechin is decomposed in the digestive tract by forming a drug such as caffeine, tannin, iron, protein, sugar chain, fat, or fatty acid that is an easy substance, such as tablets mixed with catechin and chloroquine. It will be absorbed smoothly in the intestinal tract. In particular, since the chemical structure of catechin is chemically unstable, a fatty acid using an enzyme lipase for catechin is used for the purpose of condensing a fatty acid to catechin for the purpose of obtaining a chemically stabilized chemical structure. A catechin derivative or a catechin derivative (hereinafter abbreviated as a catechin derivative) by synthesizing a new catechin compound by introducing a fatty acid into the catechin using an enzyme lipase. Is not decomposed in the intestinal tract of the digestive tract, the catechin derivative has a chemically stable chemical structure, and the catechin derivative has a chemical structure that is absorbed in the blood in the intestinal tract. Therefore, AIDS virus (HIV), Hepatitis C virus (HCV), adult leukemia virus (HTLV-1), papilloma virus (HPV), herpes virus, and influenza Development of oral medicines that can be administered orally as therapeutic means for the purpose of treating diseases caused by viruses such as Nzavirus, or drugs that are administered intraperitoneally directly with catechin derivatives It has become possible to develop or develop a pharmaceutical that directly administers a catechin derivative intravenously, or a pharmaceutical that aims to inject catechin into a drip.

  The reason for (5) is the same as that described in (4) above, when treating infectious diseases caused by viruses such as AIDS, hepatitis C, adult leukemia, and influenza. Rather than oral administration of catechin alone, drugs such as tablets containing catechin mixed with caffeine, catechin mixed with tannin, catechin mixed with iron, or catechin mixed with fatty acid Thus, catechin is absorbed smoothly in the intestinal tract without being decomposed in the digestive tract.

  Furthermore, it is a substance secreted by microorganisms, which is resistant to bacteria, resistant bacilli or resistant viruses (hereinafter abbreviated as resistant bacteria) against antibiotics that kill and kill the pathogenic microorganisms. As a result, a number of various excellent antibiotics that have been developed in the past are no longer effective as drugs. For example, penicillin, which is an antibiotic first discovered as an antibiotic and made from a solution obtained by culturing a kind of green mold, was a specific medicine for purulent diseases and pneumonia. Streptomycin, a kind of antibiotic, was a specific medicine for tuberculosis and pneumonia. However, about half a century after the discovery of penicillin or streptomycin, antibiotics such as penicillin or streptomycin have been produced by resistant bacteria, and now, most penicillin or streptomycin are present. Is currently not used. As means for reviving antibiotics in which resistant bacteria such as penicillin or streptomycin (hereinafter abbreviated as penicillin) have emerged, penicillin and 11 types of catechins (hereinafter abbreviated as catechins) shown in Table 1 are used. A penicillin derivative, which is a chemical structure having a complicated chemical structure, by causing a condensation reaction between penicillin and catechin, and penicillin and catechin being condensed. In order to form a penicillin complex, or a catechin derivative or a catechin complex (hereinafter abbreviated as a penicillin derivative or a catechin derivative), all various miscellaneous antibiotics such as penicillin or streptomycin undergo a catechin condensation reaction. Wakes up and condenses to form various miscellaneous antibiotics Penicillin and catechin are not effective at all due to the production of resistant bacteria due to the production of resistant bacteria, because it is possible to change the chemical structure of antibiotics with a new chemical structure. Or, conventional penicillin, which is an antibiotic having a complex chemical structure from the conventional penicillin or various antibiotics such as streptomycin by condensation reaction of streptomycin with catechin Or a new type of penicillin having a completely different chemical structure from streptomycin, or a new type of streptomycin (hereinafter abbreviated as pseudo-penicillin or pseudo-streptomycin), thereby making various conventional antibiotics such as penicillin or streptomycin Resistant to By using pseudo-penicillin or pseudo-streptomycin in which a condensation reaction is caused by a condensation reaction of penicillin and catechin, or streptomycin and catechin, the drug efficacy as a drug that kills resistant bacteria is avoided. The experimental results in Table 3 show that the drug has a drug effect similar to that of penicillin or conventional streptomycin.

In addition, we report the results of drinking the alkaline extract of rooibos tea extracted from rooibos tea for 2 years. Application number filed by Yoshiaki Nagaura, the inventor of the present invention, details of contents described from (1745) on page 225 to (1778) on page 242 described in Japanese Patent Application No. 2007-252588 The book is again described below, but in 1817 the British doctor James Parkinson named it shaking palsy by drinking an alkaline extract of rooibos tea extracted from rooibos tea. , "Parkinson's disease" and "Parkinson's symptoms whose main symptoms are tremor, rigidity, bradykinesia, postural disability, gait disturbance Called `` group '' For patients with the “Parkinsonism” pathology (hereinafter referred to as “Parkinson disease” for short), an alkaline extract of rooibos tea obtained by alkaline extraction of rooibos tea, for example, for serving inside a tea bag as Rooibos sodium hydrogen carbonate in 4.0 g (NaHCO ₃₎ is 0.6 g, to form a tea bag which is mixed together Rooibos and sodium hydrogen carbonate (NaHCO _3), rooibos and sodium bicarbonate ( The tea bag containing NaHCO ₃ ) is put into a tea cup containing about 200 ml of hot water, and rooibos tea is extracted with hot water, which is an alkaline aqueous solution having a pH of about 8.5. The rooibos tea alkali extract is used as a wheelchair. A patient with “Parkinson's disease” who is living in a wheelchair who cannot stand and walk when he / she drank 200 ml three times a day for about 3 months. My condition recovered before I could. From the above experimental results described above, in which a patient with “Parkinson's disease” was drunk with an alkaline extract of rooibos tea extracted from rooibos tea, (1), (2), (3), Experimental results such as 4 ▼, 5), 6), 7) and 8) can be proved.

  As a proof of the experimental result of (1), the graph (1) shown below is to Dr. Fumihiro Taguchi of the National Institute of Infectious Diseases Virus Part 3 at 4-7-1, Musashimurayama City Gakuen, Tokyo. It is the experimental result which conducted the experiment about whether it has the activity with respect to the hepatitis virus of the rooibos tea which carried out the alkali extraction using the hepatitis virus of the mouse | mouth infecting a mouse | mouth (mouse). This experimental result shows that the alkaline extract of rooibos tea that has been subjected to alkali extraction does not suppress the antiviral effect to 1/100, but the alkaline extract of rooibos has an antiviral effect. This is shown in the experimental result of graph (1).

  As proof of the experimental result of (2), the anti-viral effect of uronic acid is exhibited by the anti-viral effect of uronic acid due to the presence of acidic polysaccharide containing uronic acid in high concentration in the alkaline extract of rooibos tea. You may judge that there is. This acidic polysaccharide containing uronic acid has been shown to exhibit antiviral effects such as anti-HIV effects.

  As a proof of the experimental result of (3), the mechanism of why the disease whose name is “Parkinson's disease” develops has not been elucidated. Judging from both the experimental results and the experimental results in the following graph (1), the experimental results shown in the following graph (1) indicate that the alkaline extract of Rooibos has an antiviral effect. Has been proved. It can be judged from this that the disease name is a causal factor of the mechanism that causes “Parkinson's disease”, and that a certain type of virus is mediated to cause “Parkinson's disease”. Although it has not been identified, it may be judged that a certain type of virus is intervening, but the fact that it can be judged from the situation described above is that “Parkinson” is an incurable disease of unknown cause. “Disease” can be determined to be caused by some kind of virus.

As proof of the experimental result of (4), unlike the contents explained in (3) above, the cause of the effect of improving “Parkinson's disease” is as follows from the rooibos tea shown in Table 4. It can be said that trace metal minerals contained in rooibos tea, which are shown in the analysis table of the extract, are effective in improving “Parkinson's disease”.

  As proof of the experimental result of (5), unlike the contents described in (3) and (4) above, the cause of the effect of improving “Parkinson's disease” is shown in Table 4 above. Although it is not described as analysis data in the analysis table of the extract from Rooibos tea, the extract from Rooibos tea may contain catechin. However, since catechin is highly reactive, it is condensed with tannin and iron by condensation reaction, so it is judged that the extract from rooibos does not contain catechin. Since there is a possibility, it may be analytical data as shown in Table 4. However, in reality, catechin may exist inside the extract from rooibos tea. Therefore, antioxidative action and scavenge action (reactive oxygen scavenging / removing action) of rooibos tea May be involved.

  As proof of the experimental result of (6), in the experimental result shown in the graph (1) below, the hepatitis virus of the mouse infected by the mouse is converted into an alkaline extract of rooibos tea extracted from rooibos tea. The experiment results in graph (1) show that mice inactivated the hepatitis virus that infects mice. Therefore, as an remedy for hepatitis A, hepatitis B, and hepatitis C (hereinafter abbreviated as hepatitis C), which is infected by the human body, an alkali of rooibos tea extracted from rooibos tea is used. It shows that the extract is a therapeutic means for hepatitis C. Alkaline extraction from rooibos tea is also used as a treatment for patients infected with adult leukemia virus, papilloma virus, rotavirus, norovirus, influenza virus, herpes virus, and AIDS virus (hereinafter abbreviated as AIDS virus). The experimental results of the following graph (1) show that the alkaline extract of rooibos tea has a medicinal effect as a therapeutic means for AIDS virus patients.

As proof of the experimental result of (7), in order to perform alkali extraction from rooibos tea, for example, 4.0 g rooibos tea inside the tea bag for 1 serving, sodium bicarbonate (NaHCo ₃ ) A tea bag with 0.6 g of the tea bag is formed together, and a roasting tea is 4.0 g in the inside of the mug in which 200 ml of hot water is put inside the tea cup or mug (hereinafter abbreviated as mug). It is most convenient to drink a tea bag containing sodium bicarbonate (NaHCo ₃ ) together with 0.6 g in a mug containing 200 ml of hot water, followed by alkaline extraction from rooibos tea. Turned out to be a safe drinking method.

  As a proof of the experimental result of (8), as described in (1) to (5) above, a rooibos tea extracted from rooibos tea for a patient whose disease name is currently unknown as “Parkinson's disease”. When a patient with “Parkinson's disease” drinks alkaline extract for several months, for example for a period of 2 to 3 months, a patient with “Parkinson's disease” who lives in a wheelchair can stand and walk If it is determined that the cause of the onset of “Parkinson's disease” is the trigger of the onset of virus, 98% or more of the 11 types described in Table 1 described above Purified single catechin, polyphenone 70S, sanphenone BG-3, or other catechins were passed to patients with “Parkinson's disease”. Alkaline from Rooibos tea that the name of the disease whose cause is currently unknown as an intractable disease will be a therapeutic means for patients with “Parkinson's disease” by internal administration, intraperitoneal administration, or intravenous administration. It is an experimental result that can be determined from an experimental result in which a patient with “Parkinson's disease” has also drunk the extracted alkaline extract of rooibos tea.

In addition, graph (1) shown below is a mouse infecting a mouse with Dr. Fumihiro Taguchi of the National Institute of Infectious Diseases Virus Part 3 in 4-7-1, Musashimurayama City Gakuen, Tokyo. The results of experiments on whether or not octagonally ground fine powder, rooibos tea, Tochu tea, and chlorella have or are not active against murine hepatitis virus using is there.

Further, the experimental result graph (1) described above will be described as graph (1) and FIG. 3 below. FIG. 3 shows a finely crushed octagon inside the tea bag. Four different types of tea bags, each containing 7.0 g of powder, 4.0 g of rooibos tea, 4.0 g of Tochu tea, and 4.0 g of chlorella, were created. Four tea bags with 0.6g sodium bicarbonate (NaHCO ₃ ) in each tea bag are made, and about 200 ml of hot water is put inside four tea cups (mugs). , Put each inside the individual tea cup, make the pH of the boiled hot water boiled inside the tea cup alkaline is 8.5 or more, and put the tea bag in the tea cup for about 1 hour A mouse is infected with an aqueous solution obtained by alkaline extraction of four different types of active ingredients, using alkaline hot water with a PH concentration of 8.5 or higher. The experimental results for activity on the murine hepatitis virus are shown in FIG.

In addition, the Control shown in FIG. 3 is a tea bag in which only 4.0 g of rooibos tea is put in the tea bag and no sodium hydrogen carbonate (NaHCO ₃ ) is added. Extract hot water boiled in almost neutral tap water from Musashimurayama, Tokyo, with a PH concentration of around 0, using hot water inside a tea cup containing approximately 200 ml, as above. In addition, an aqueous solution containing an active ingredient of rooibos tea is used as Control.

  Furthermore, the activity against the hepatitis virus of the mouse infected with the active ingredient obtained by alkaline extraction from the four types of octagon, rooibos tea, tochu tea and chlorella shown in FIG. 3 described above. Compared to Control extracted from rooibos tea, the active ingredient obtained by alkali extraction from three types of octagon, tochu tea, and chlorella, which were also alkali extracted, other than rooibos tea that was alkali extracted in the alkali extracted fraction Graph (1) shows that the experimental result of not being able to inactivate the hepatitis virus of a mouse infected with a mouse is shown in FIG.

Now, as a conclusion, the experimental results shown in FIG. 3 show that using a tea bag in which 4.0 g of rooibos tea and 0.6 g of sodium bicarbonate (NaHCO ₃ ) are put together inside the tea bag, The aqueous solution containing the active ingredient of rooibos tea, which was alkali-extracted in the alkaline extraction fraction using a tea bag containing rooibos tea and sodium hydrogen carbonate (NaHCO ₃ ), contained 1 ml of Control. 10 ⁶ murine hepatitis virus (3 million before and after) to 10 ⁴ (46,000 units back and forth), the number of digits of about two orders of magnitude but could be reduced by inactivating, exactly Figure 3 shows the results of an experiment that succeeded in inactivating the rat hepatitis virus, which was not inactivated until 1/100 but was infected by about 1/65. .

  Furthermore, the murine hepatitis virus used in the experimental results shown in FIG. 3 and infected with the coronavirus mouse is a serotype classified as a coronavirus mate and a highly virulent highly pathogenic avian influenza (H5N1 type). ) And the same fellow coronavirus, the experimental results shown in FIG. 5 show that the human body is infected, including the hepatitis C virus that infects the human body, highly virulent highly pathogenic avian influenza ( FIG. 3 also shows experimental results demonstrating that it can be used as a therapeutic means for infectious diseases caused by coronaviruses such as H5N1), hepatitis A, hepatitis B, and hepatitis C.

In addition, retroviruses such as herpes virus, HIV virus, adult T cell leukemia virus, papilloma virus, Ebola virus, and rotavirus, which have exactly the same structure as that of coronavirus, and retrovirus-like The structure is also the same as a coronavirus because there is a nucleic acid in the center, and the structure is a virus with a structure in which the outer periphery of the nucleic acid is protected by the envelope that is the epidermis, with the central nucleic acid as the center Because it is a virus with a structure, make a tea bag that contains about 2.0 g, 3.0 g, or 4.0 g of rooibos tea and about 0.6 g of sodium bicarbonate (NaHCO ₃ ). , Alkaline extraction from rooibos tea inside a tea cup with about 200 ml of boiling hot water As in the experimental results shown in FIG. 3, the active ingredient extracted with alkali in the fraction can inactivate herpes virus, HIV virus, adult T cell leukemia virus, Ebola hemorrhagic fever virus, and rotavirus. Therefore, the experimental results shown in FIG. 3 indicate that it is a therapeutic means for infectious diseases caused by the HIV viruses and rotaviruses listed above.

  Further, for example, the alkaline substance put together with the rooibos tea in the tea bag described above is sodium bicarbonate, and the alkaline substance other than calcium hydroxide is sodium carbonate, potassium hydroxide, water. An alkaline substance such as sodium oxide and ammonium hydroxide may be placed inside the tea bag, and any one of the alkaline substances may be put together with the rooibos tea.

Moreover, what was found from the experimental results of the experiment shown in FIG. 3 is that, for example, 2.0 g, 3.0 g, 4.0 g, 8.0 g, or 10. 0 g or about 12.0 g and sodium bicarbonate (NaHCO ₃ ) 0.1 g or more, or 0.2 g or more, or 0.3 g or more, or 0.4 g or more, or 0.5 g or more, or 0 0.6 g or more, or 0.7 g or more, or 0.8 or more, or 0.9 g or more, or 1.0 g or more, or 2.0 g or more, or 3.0 g or more of sodium bicarbonate (NaHCO ₃ ) Put the tea bag inside the tea bag together with 200ml to 220ml of boiling tea water, and reduce the PH concentration of the hot water inside the tea cup. Cali or more 7.2 or more, or 7.4 or more, or 7.6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more, or 9.0 or more, or 9.5 or more, Alternatively, an aqueous solution obtained by alkali-extracting the active ingredient contained in the rooibos tea from the rooibos tea in the alkali extraction fraction using hot water made alkaline of 10.0 or more or 11.0 or more is described above. The experimental results shown in FIG. 3 also show that the experiment results shown in FIG. 3 are indirectly proved to be effective when used as therapeutic means for hepatitis C patients, AIDS patients, or rotavirus patients. But there is.

In addition, for example, by using a container such as a kettle or a pan, the effective component contained in the rooibos tea is extracted from the rooibos tea in the alkaline extraction fraction, and the rooibos tea contains When making a lot of aqueous solution containing ingredients, for example, make a tea bag with about 10 g of rooibos tea and about 2.0 g of sodium bicarbonate (NaHCO ₃ ) inside the tea bag. Put one to two liters of water in the kettle, and a tea bag containing 10 g of rooibos tea and 2.0 g of sodium bicarbonate (NaHCO ₃ ) inside the kettle containing water. Or put 2 bags or 3 bags into the aqueous solution inside the kettle, and adjust the PH concentration of the aqueous solution inside the kettle inside the tea bag. Sodium bicarbonate (NaHCO ₃ ) contained in the kettle is dissolved inside the kettle, and the PH concentration of the aqueous solution inside the kettle is an alkaline aqueous solution. The PH concentration is 7.2 or more, or 7.4 or more Or 7.6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or Using an alkaline aqueous solution inside the kettle, which is an alkaline aqueous solution of 11.0 or more, boil and boil the rooibos tea contained in the tea bag, and further boil for about 10 minutes Continue to stop the fire, leave the tea bag inside the kettle for about 1 hour, let it cool, and then take the tea bag out of the kettle. Le When the alkaline extraction with an alkali-extracted fraction from Bosuti, it will be able to make very easily easily alkaline extraction from rooibos.

In the case of draining water, as described above, for example, a tea bag having about 10 g of rooibos tea and about 2.0 g of sodium bicarbonate (NaHCO ₃ ) in the tea bag. 2 or 3 bags are put into a container containing about 800 ml of an aqueous solution and cooled in a refrigerator, and the pH of the aqueous solution inside the container is set to the hydrogen carbonate in the tea bag. When sodium (NaHCO ₃ ) is dissolved in the aqueous solution inside the container, the PH concentration of the aqueous solution inside the container is an alkaline aqueous solution, and the PH concentration is 7.2 or more, 7.4 or more, or 7. 6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more Arca An active ingredient contained in rooibos tea in an alkaline extract fraction from rooibos tea in the tea bag using an alkaline aqueous solution inside the container. Can be extracted with alkali very easily.

  Furthermore, for example, a fine powder such as rooibos tea, grassroots bark or herbal medicine (hereinafter abbreviated as rooibos tea) and an alkaline substance are put together in the tea bag, Alkaline substances used for alkali extraction from the rooibos tea contained in the alkali extraction fraction include sodium carbonate, sodium bicarbonate, potassium hydroxide, sodium hydroxide, and ammonium hydroxide. One type of tea can be put inside the tea bag, or two or more alkaline substances can be put inside the tea bag together with rooibos tea, for example, sodium carbonate with rooibos tea as an alkaline substance. Put the tea bag in the inside of cold water that is aqueous solution or boiling hot water, The sodium carbonate contained in the bag is dissolved in cold water or boiling hot water, and the PH concentration of the cold water or boiling hot water is 7.2 or higher, or 7.4 or higher, or 7.6 or more, or 7.8 or more, or 8.0 or more, or 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11. The rooibos tea contains from the rooibos tea which is put in the inside of the tea bag by using cold water or boiling hot water which is an alkaline aqueous solution of 0 or more, 11.5 or more or 12.0 or more. Food ingredients, foods, health foods, drinking water, drinking water ingredients, alcoholic drinking water, shochu ingredients, tay pack ingredients, tay packs Raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and a manufacturing method thereof.

  Further, a fine powder (hereinafter abbreviated as instant rooibos tea) obtained by drying an aqueous solution extracted using boiling water in which rooibos is boiled by a drying means such as spray drying or freeze drying, for example, Create a stick with an instant rooibos tea and, for example, sodium carbonate, which is an alkaline substance, inside the stick when putting it in a small bag (hereinafter abbreviated as a stick), for example, a tea cup Cold water, which is an aqueous solution contained in the inside of the water, or sodium carbonate contained with the instant rooibos tea contained in the stick inside the boiling hot water, for example, cold water inside the tea cup Or use cold water or hot water with a PH concentration of hot water of 7.5 or higher, or 8.0 or higher. Food raw material characterized in that the active ingredient contained in instant rooibos tea in the alkali extract fraction from stun trubos tea is cold extracted from hot water or hot water as drinking water or other foods , Food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

  Furthermore, rooibos tea and, for example, sodium carbonate, which is an alkaline substance, are put together in boiling hot water, and sodium carbonate is dissolved in boiling hot water. An aqueous solution containing an active ingredient of rooibos, obtained by subjecting an active ingredient contained in rooibos to an alkaline extraction fraction using an alkaline extraction fraction using an alkaline boiling hot water of 8.5 or more Is a fine powder (hereinafter abbreviated as alkaline instant rooibos, which has been alkali-extracted from rooibos tea which has been dried by spray drying or drying means such as freeze-drying and which has been changed to alkaline properties. ), For example, in a small bag (hereinafter abbreviated as a stick) For example, using cold water in a container such as a tea cup, or hot water to dissolve alkalinized instant rooibos tea or hot water as drinking water, or other food Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

  Also, inside the boiling hot water, rooibos tea and alkaline substance sodium carbonate, or sodium bicarbonate, potassium hydroxide, sodium hydroxide, ammonium hydroxide, or ammonia water (hereinafter abbreviated, (Sodium carbonate) is put together in the boiling hot water, the active ingredients contained in the rooibos tea, the PH concentration of the boiling hot water, and the alkaline substance sodium carbonate dissolved The PH concentration is 7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8 or higher, or 8.0 or higher, or 8.5 or higher, or 9.0 or higher, or 9. 5 or more, 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more, or 12.0 or more alkaline aqueous solution, boiling hot water or cooling Teter Pak is a container made of boiling hot water obtained by alkaline extraction of the active ingredients contained in rooibos tea with an alkaline extraction fraction using cold water, or a plastic bottle or paper made of cooled cold water It is distributed in containers such as drinking water as drinking water, or it is made into alkaline carbonated drinking water containing carbon dioxide gas using a plastic bottle, or other food products Food raw material, food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

  Furthermore, using an alkaline substance such as rooibos and sodium carbonate or sodium bicarbonate, for example, the PH concentration is 7.2 or more, or 7.4 or more, or 7.6 or more, or 7.8 or more, Or 8.0 or more, or 8.5 or more, or 9.0 or more, or 9.5 or more, or 10.0 or more, or 10.5 or more, or 11.0 or more, or 11.5 or more, or 12. Use an aqueous solution containing an active ingredient of rooibos, which has been subjected to alkali extraction in the alkaline extraction fraction using cold water, which is an aqueous solution of 0 or more, or boiling hot water, or contained by rooibos tea Examples of the method of using fine powder obtained by converting an aqueous solution obtained by alkaline extraction of an active ingredient with an alkaline extraction fraction into fine powder using a drying means such as spray drying or freeze drying include, for example, type A liver Or hepatitis B, hepatitis C, or other similar forms of hepatitis virus, papilloma virus, saas virus, influenza virus, rotavirus, herpes virus, coronavirus such as HIV virus, or retrovirus, etc. The envelope, which is the epidermis, is particularly effective for viruses in the shape of viruses around the nucleic acid centered on the nucleic acid, so it can be used as a food ingredient or food additive with an antiviral effect, or all sorts of miscellaneous Food, frozen confectionery, drinking water, and alcoholic beverages can be used as an additive or can be used as a main ingredient, for example, bread such as bread, confectionery additive, or rice cake, donut, cake, Japanese confectionery As an additive such as udon, ramen, spaghetti, macaroni As an additive of rice, as an additive of rice and rice balls, lunch boxes, etc., or as an additive such as popsicle, ice cream, blow ice, bar ice, or as an ingredient, as an additive of drinking water, or as an ingredient Or an active ingredient with an antiviral effect that is alkali extracted from rooibos tea in an alkaline extract fraction by using it as an additive for alcoholic beverages such as shochu, sake, vodka, whiskey, or as a main raw material The effect of being able to inactivate viruses at the cellular level for the human body to ingest easily and fight against various kinds of viruses, and to enhance the immunity of the human body to resist against viruses Food raw materials, foods, health foods, drinking water, drinking water raw materials, Lecol drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and methods for producing the same.

Further, the PH concentration of boiled hot water, boiled hot water, cold water, or a low-temperature aqueous solution (hereinafter abbreviated as cold water) equal to or lower than room temperature is set to, for example, sodium carbonate (Na ₂ CO ₃ ), or Using an alkaline substance such as sodium hydrogen carbonate (NaHCO ₃ ), for example, the pH concentration of cold water is 7.2 or higher, or 7.5 or higher, or 8.0 or higher, or 8.5 or higher, or 9. Using an aqueous solution of 0 or more, 9.5 or more, or 10.0 or more alkaline cold water, for example, rooibos = commonly called red shrub branches, trunks, roots, leaves and other fine powder, or grassroots bark The active ingredient contained in rooibos tea from rooibosti (hereinafter abbreviated as rooibosti) from fine powder, or herbal medicine in fine powder, or rooibosti in cold water at room temperature or lower AIDS patients who develop an aqueous solution that has been alkali extracted with an alkaline extraction fraction from hepatitis A, hepatitis B, hepatitis C, or other similar forms of hepatitis virus, or other infectious disease-causing viruses As a means for concentrating an ultra-high concentration of acidic polysaccharide such as uronic acid, neutral sugar, or reducing sugar contained in rooibos tea, for example, cold water at room temperature or lower, Alternatively, the aqueous solution obtained by alkali extraction from the rooibos tea in the boiling hot water with the alkali extraction fraction is dried by a drying means such as spray drying or freeze drying, so that the active ingredient of rooibos tea is made to have an ultra-high concentration. When the concentrated fine powder is used as a treatment for AIDS patients who develop hepatitis virus or other infectious disease-causing viruses, Coronas such as hepatitis virus, herpes virus, rotavirus, saas virus, influenza virus, papilloma virus, and HIV virus are acidic polysaccharides such as uronic acid, neutral sugar, or reducing sugar that have been alkali-extracted from the potassium extract fraction. Food raw materials, foods and health characterized by inactivating various kinds of viruses and treating many intractable diseases by neutralizing spikes on the surface of the envelope of viruses or retroviruses Food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

Further, using an alkaline substance such as sodium carbonate (Na ₂ CO ₃ ) or sodium hydrogen carbonate (NaHCO ₃ ) from Rooibos tea, for example, cold water that is an aqueous solution having a PH concentration of 8.5 or more, or room temperature When the active ingredients contained in rooibos tea are alkali extracted with the alkaline extraction fraction at the following low temperatures, the rooibos is placed in cold water or a low temperature aqueous solution over several days. Food ingredients, foods, health foods, drinking water, drinking water ingredients, alcoholic beverages, shochu ingredients, characterized in that tea is soaked and the active ingredients contained in rooibos tea are extracted with an alkali extraction fraction. , Tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

  In addition, uronic acid obtained by alkali extraction from rooibos tea, mangrove, or 11 types of catechins shown in (Table 1) (hereinafter abbreviated as rooibos tea or catechin) in an alkali extraction fraction The reason why acidic polysaccharides such as neutral sugars and reducing sugars inactivate coronaviruses or retroviruses is that the acceptor of key proteins present on the surface of the virus is inactivated, so human cells Since the properties or characteristics of the keyhole protein receptor on the surface of the virus will not match, the virus will not be able to adsorb to the receptor present on the cell surface using the acceptor present on the surface of the virus. . Normally, if the acceptor present on the surface of the virus matches the nature or characteristics of the receptor present on the surface of a human cell, the virus will only enter the inside of the cell, and the viral gene There are two ways of intrusion when invading with a wrapped bag. The problem is that an active ingredient obtained by alkaline extraction from rooibos tea, or 11 kinds of active ingredients shown in (Table 1), variously react by inactivating the acceptor present on the surface of the virus. Regardless of the type of virus, the virus can attach to a receptor present on the surface of the cell, adsorb to the cell and block it from entering the cell, and the virus can enter the cell. Since it has the greatest feature in inactivating the virus without being able to do it, the first effect is that, for example, even if the HIV virus invades the human body, the HIV virus uses an acceptor in human cells. Since it is unable to enter the interior of the cell, viral genes result in blocked synthesis and proliferation, so Rooibos, or (Table 1) The active ingredient contained in the 11 types of catechins shown, for example, does not become an AIDS patient because it blocks and protects against the invasion of HIV virus into the human body. The first effect is that it has a preventive effect, and the second effect is that the virus is blocked and protected on the surface of the cell, so that the emergence of resistant strains such as HIV virus as other drugs The advantage that does not occur is the second effect. The third effect is that there is no side effect at all. On the surface of the virus using an active ingredient such as an acidic polysaccharide obtained by alkali extraction of rooibosty or 11 kinds of catechins shown in (Table 1) with an alkali extracted fraction. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials characterized by inactivating an acceptor to block and protect it from adsorbing on the surface of human cells , Tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

  Further, inside the boiling hot water, rooibos tea and alkaline substances such as sodium carbonate, sodium bicarbonate, potassium hydroxide, sodium hydroxide, ammonium hydroxide, or ammonia water (hereinafter abbreviated). , Sodium carbonate) into the boiling hot water together, the active ingredients contained in the rooibos tea, the PH concentration of the boiling hot water, the alkaline substance sodium carbonate When dissolved, the PH concentration is 7.2 or higher, or 7.4 or higher, or 7.6 or higher, or 7.8 or higher, or 8.0 or higher, or 8.5 or higher, or 9.0 or higher, or 9 Boiling hot water which is an alkaline aqueous solution of 5 or more, 10.0 or more, 10.5 or more, 11.0 or more, 11.5 or more, or 12.0 or more, Boiling hot water obtained by alkaline extraction of the active ingredients contained in rooibos tea with an alkali extraction fraction using cooled cold water, or cooled cold water, for example, alkaline with a PH concentration of 8.5 or higher The PH concentration of an aqueous solution obtained by alkaline extraction of an active ingredient contained in rooibos tea using a boiling aqueous solution of the above is weakly alkaline with a PH concentration of 7.4 or less gentle to the human body, or a PH concentration of 7. It is characterized by using acidic substances such as hydrochloric acid (HCI), ground water, or other aqueous solutions to make the pH concentration acidic or slightly alkaline drinking water in order to obtain an acidic pH concentration of 0 or less. Food raw materials, food, health food, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals , Alcohol raw materials, and a manufacturing method thereof.

  In addition, to extract active ingredients such as uronic acid, neutral sugar, or reducing sugar contained in rooibos tea, mangroves, or pine nut shells (hereinafter abbreviated as rooibos tea) An alkaline substance such as sodium carbonate or sodium hydrogen carbonate is added to the inside of a boiling aqueous solution having a PH concentration of 8.0 or more and within 12.0. Alkaline aqueous solution obtained by alkaline extraction using an alkaline aqueous solution having a PH concentration of 8.0 or higher and within 12.0 or less from rooibos tea, which has been subjected to alkaline extraction of the active ingredient, is more effective than the alkaline aqueous solution. An acidic aqueous solution with a PH concentration of 3.0 or more and 7.4 or less, or a weakly alkaline solution with a PH concentration of 7.4 or less. In order to obtain a solution, hydrochloric acid (HCI), other acidic substances, or an aqueous solution such as ground water or natural water is used to dilute an alkaline aqueous solution so as to become an acidic aqueous solution. 7.4 or less weakly alkaline or acidic drinking water with a PH concentration of 7.0 or less, which can be stored for a long period of time, prevents germs from breeding, and does not rot easily. When extracting the active ingredients, the alkaline concentration is used to extract the effective ingredients contained in the rooibos tea using an alkaline aqueous solution having a PH concentration of, for example, 8.0 to 12.0. For example, when filling a container such as a PET bottle, a weak alkaline aqueous solution having a PH concentration of 7.4 or less, or an acidic beverage having a PH concentration of 3.0 or more and 7.0 or less. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production thereof Method.

  Furthermore, using an active ingredient contained in rooibos tea, or mangrove, or pine nut shell (hereinafter abbreviated as rooibos tea), HIV virus for AIDS patients, or HBV virus for hepatitis patients, Alternatively, to extract an antiviral substance from rooibos that can inactivate viruses such as HCV virus, hepatitis patient's HCV virus, influenza virus such as H5N1 or Thurs virus, a PH concentration of 8 Uronic acid, which is a substance having an antiviral effect, unless the alkaline extraction is carried out using a boiling aqueous solution having a pH as high as possible within a range from 0.0 to 12.0 and being as high as possible. It is not possible to extract a large amount of acidic polysaccharides such as natural sugar or reducing sugar from rooibos tea effectively. The alkaline aqueous solution having an anti-viral effect contained in rooibos, which has a pH of 8.0 or more and within 12.0, was used directly for drinking water from rooibos tea. Because of its strong alkaline aqueous solution with a PH concentration of 8.0 or more and within 12.0, it is unsuitable for direct drinking water, so hydrochloric acid (HCI) or other acidic substances, or groundwater, Or, using natural water or other aqueous solution, diluting the PH concentration to a human-friendly PH concentration of 3.0 to 7.4 and reducing the antiviral effect that Rooibos tea contains Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, characterized in that an aqueous solution containing a substance is made into drinking water gentle to the human body, E pack raw materials, tee pack, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and a manufacturing method thereof.

In addition, the National Infectious Disease Research in 4-7-1, Musashimurayama Gakuen, Tokyo, using an aqueous solution obtained by adding rooibos tea into the boiling aqueous solution with a pH of 8.5. Graph (1) shows the results of an experiment conducted by Prof. Fumihiro Taguchi of the Tokoro Virus Department 3. The virus used in this experiment is a hepatitis virus that belongs to a coronavirus that infects mice. The control result shown in the graph (1) is obtained from a rooibos tea using a neutral and boiling aqueous solution having a pH of 7.0. It is the experimental result of inactivating the hepatitis virus that infects mice using the extracted aqueous solution, and the rooibos in the bar graph shown in graph (1) boils the aqueous solution with a pH of 8.5. The experimental result of using this neutral boiling aqueous solution, which is the experimental result of inactivating the hepatitis virus that infects mice using the alkaline aqueous solution, and the PH concentration was set to 8.5 Comparing two experimental results, the result of alkaline extraction from rooibos tea using an aqueous solution in which the aqueous solution is boiled and the control result of Control, Control shows that the number of viruses is on the order of 10 ⁶ . Using an alkaline aqueous solution with a PH concentration of 8.5, the alkaline extract was obtained from rooibos tea. The active ingredient contained in rooibos was extracted with an alkaline aqueous solution. The inactivation effect shows that the bar graph in graph (1) shows the experimental results where the number of viruses has dropped to the 10 ^4th power The number of viruses is from the 10 ^6th power to the 10 ^4th power, and the experimental results shown in Table 1 are shown. The octagon, tochu tea and chlorella shown in (1) are also used in the same manner as the rooibos tea, using an aqueous solution in which an aqueous solution having a PH concentration of 8.5 is boiled. The results of experiments using an aqueous solution obtained by alkaline extraction from an aqueous solution of chlorella using an alkaline aqueous solution were the results of experiments where neither octagon, Tochucha nor chlorella was able to inactivate the virus at all. So, why is the aqueous solution extracted from alkali only from Rooibos effective to inactivate the virus? Currently, there are about 30,000 types of viruses. Although most types of viruses have been found, the majority of viruses are from Rooibos tea, which is composed of more than 90% of viruses with a structure with epidermal proteins around the nucleic acid. The alkaline extracted aqueous solution damages the key protein, which is an acceptor necessary for the virus to adsorb to the host cell, and disables the key protein, so that the virus can adsorb to the host cell. The result of the experiment shown in the graph (1) can be judged to indicate that it has disappeared and can no longer function as a virus. If the result of the experiment is true, whether it is an AIDS patient caused by HIV virus or a hepatitis patient caused by HBV virus or HCV virus In addition, in patients with influenza caused by viruses such as H5N1 type, patients with herpes virus, or SARS patients with severe acute respiratory syndrome, other nucleic acids are mainly epidermal proteins around the nucleic acid. It was decided that it would be possible to prevent and treat all diseases caused by viruses with the structure of viruses. The discovery of the action and effect that prevents the virus from adsorbing to the host cell by ingesting the virus as described above by ingesting, for example, if it is an AIDS patient, the AIDS patient From the body of the AIDS patient, the virus that causes the AIDS patient Food raw material, food, health food, drinking water, drinking water raw material, alcoholic beverage characterized by providing drinking water that is an aqueous solution for use as a therapeutic means Water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and manufacturing method thereof.

Furthermore, rooibos, mangroves, or pine nut shells (hereinafter abbreviated as rooibos) are basically acidic substances with an acid value of 5.0 or less, so the PH concentration is medium. Even if an active ingredient contained in rooibos tea is extracted using an aqueous solution of about 7.0, the rooibos tea is an acidic substance, so even if an aqueous solution with a pH of 7.0 is used, Even if the active ingredient contained in Rooibos tea is extracted, the aqueous solution will become acidic and the PH concentration will be around 6.0. Therefore, the purpose is to extract the active ingredient from rooibos tea with rooibos tea. of an aqueous solution of an aqueous solution of PH concentration 6.0 before and after the acid, sodium carbonate _(Na 2 _CO 3), or sodium bicarbonate (NaHCO ₃₎ using an alkaline substance such as the PH concentration 0.0 to 12.0 or less alkaline aqueous solution, then heated to boil and boiled, and as shown in Table 1, the active ingredient with antiviral effect contained in rooibos is alkali extracted After that, an alkaline aqueous solution containing an active ingredient having antiviral effect obtained by alkali extraction from rooibos tea is adjusted to pH 7 using hydrochloric acid, other acidic substances, ground water or natural water. An aqueous solution containing an active ingredient having a weak alkalinity of 4 or less, or an acidic aqueous solution containing an active ingredient having a PH concentration of 7.0 or less, or an active ingredient having a PH concentration of 6.0 or less Or an acidic aqueous solution containing an active ingredient having a PH concentration of 5.0 or less, or an acidic aqueous solution containing an active ingredient having a PH concentration of 4.0 or less It can be an aqueous solution or an acidic aqueous solution containing an active ingredient having a PH concentration of 3.0 or less, which is a drinking water which is an aqueous solution in a state where it is difficult for germs to propagate. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic drinking water, shochu raw materials, Tei, characterized by providing acidic drinking water that has been made acidic for the purpose of preventing decay for a long period of time Pack raw material, Tee pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, mangrove, or pine nut shell (hereinafter abbreviated as rooibos tea), sodium carbonate (Na ₂ CO ₃ ), sodium hydrogen carbonate (NaHCO ₃ ), etc. inside the tea bag Make a tea bag together with an alkaline substance (hereinafter abbreviated as sodium carbonate) in the inside of the tea bag, and use the active ingredients that Rooibos tea contains in the boiling aqueous solution. When alkaline extraction is performed, or when the active ingredients contained in rooibos tea are extracted in cold cold water, the rooibos and sodium carbonate are mixed together in a sealed tea bag container. In addition, the active ingredient and sodium carbonate contained in Rooibos tea inside the sealed container of the tea bag is a sealed container The inside of the bag will undergo a chemical reaction as a highly concentrated alkaline aqueous solution, and the active ingredients contained in the rooibos tea will be sealed using sodium carbonate that is sealed inside the tea bag. Food ingredients, foods, health foods, and beverages characterized by a chemical reaction in an alkaline aqueous solution with a higher PH concentration inside the tea bag and alkaline extraction from rooibos tea Water, drinking water raw materials, alcoholic drinking water, shochu raw materials, tay pack raw materials, tay packs, feed raw materials, pharmaceutical raw materials, pharmaceuticals, alcohol raw materials, and production methods thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). Is a redox potential, which is a measure of the activity of a substance that eliminates and removes bad active oxygen generated in the human body, and the higher the positive value, the stronger the ability to oxidize. The larger the is, the stronger the reduction power, and the richer the amount of active hydrogen (negative ions). A substance that scavenges and removes active oxygen is generally called a scavenger, and it is paradoxically explained that rooibos tea has a strong scavenging action of active oxygen removal. Tea has the ability to store hydrogen ions (hereinafter abbreviated as active hydrogen) in an aqueous solution, and rooibos contains active hydrogen in the form of negative ions (active hydrogen content). Active hydrogen in the form of negative ions present in the aqueous solution extracted from the active ingredients contained in rooibos tea using hot water or cold water as a result, scavenging and removing active oxygen And neutralize. For the purpose of further increasing the storage capacity of this rooibosty that stores negative hydrogen active hydrogen, for example, the rooibosty is placed inside a container filled with hydrogen gas, The tea bag containing the rooibos tea and the hydrogen gas are put together inside the container formed using a film that cannot pass the hydrogen gas through the tea bag containing the rooibos tea. To make the rooibos tea absorb hydrogen gas, or inside the tea bag containing the rooibos tea, sodium hydrogen carbonate (NaHCO ₃ ), sodium carbonate, or other alkaline substance (hereinafter abbreviated, and sodium carbonate _(Na 2 CO ₃₎₎ and put Rooibos together, Tiba' Concentration inside in an aqueous solution of sodium carbonate (Na 2 _{CO 3)} are put together with the rooibos and to deviate by liberating sodium carbonate (Na 2 _{CO 3)} active hydrogen content (negative ions) is high It has been found that the concentration of active hydrogen (negative ion) becomes. For example, an aqueous solution containing active hydrogen having an active hydrogen amount (negative ion) with an oxidation-reduction potential of −100 or −200 or higher in the amount of active hydrogen (negative ions) is used as rooibos and sodium carbonate (Na ₂ CO _3). Food ingredients, foods, health foods, drinking water, drinking water ingredients, alcoholic drinking water, shochu ingredients, tay pack ingredients, tay packs, feed ingredients, pharmaceutical ingredients, pharmaceuticals, alcohol Raw materials and manufacturing method thereof.

In addition, a country that constantly drinks groundwater containing a large amount of scavenging active hydrogen, which eliminates and removes active oxygen generated in the human body, is famous for its longevity. It is said that the groundwater which is the mineral water of this Hunza kingdom, which contains the active hydrogen whose oxidation-reduction potential is -100 to -200 or more, which is a unit of the amount of active hydrogen (negative ions). The ultra-high concentration of active hydrogen contained in the groundwater of the Kingdom of Hunza can reduce the incidence of cancer and reduce the incidence of other diseases. The longest-lived over 100-year-old country has a phenomenal longevity. The ground water of the Hunza Kingdom contains abundant active hydrogen containing aqueous solution as drinking water. It is to be closely related and long longevity life expectancy that use. Also, in Japan, for example, the analysis result of mineral water, which is the groundwater sold under the trade name Hita's Tenryo Water, shows that the redox potential is +80 to +190. The amount of active hydrogen (negative ions) contained in heavenly water is the mineral water with the highest concentration of active hydrogen (negative ions) among the mineral waters sold in Japan. Compared to the ground water of the Kingdom of Hunza, the groundwater that is the mineral water of the Kingdom of Hunza contains about several tens of times the amount of active hydrogen. , The longevity of the Hunza kingdom.
Further, even in the groundwater of the Kingdom of Hunza, the amount of active hydrogen (negative ions) disappears from the aqueous solution in 2 to 3 days, so that it cannot be stored and transported for a long time. Therefore, anytime, anywhere drinking water containing active hydrogen that has a redox potential equivalent to the amount of active hydrogen (negative ions) similar to groundwater in the Kingdom of Hunza is easily equivalent to that of the Hunza Kingdom. As means for preparing drinking water containing, for example, rooibos tea, or mangrove, or pine nut shell, or green tea, or black tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea Inside a tea bag containing tea or coffee (hereinafter abbreviated as Rooibos tea), sodium hydrogen carbonate (NaHCO ₃ ), sodium carbonate (Na ₂ CO ₃ ), or other alkaline substances (hereinafter referred to as Abbreviated sodium carbonate (Na ₂ CO ₃ ), for example, inside a tea bag containing rooibos tea The amount of active hydrogen (negative ions) is reduced by alkali extraction using hot water or cold water boiled using a tea bag containing sodium carbonate (Na ₂ CO ₃ ) inside the tea bag. Contains active hydrogen equivalent to the amount of active hydrogen (negative ions) in the ground water of Hunza, with a redox potential equivalent to -100 to -200 or more equivalent to the amount of active hydrogen (negative ions) contained in the ground water of Hunza It has been found that the drinking water can be made. In addition, the means for generating active hydrogen in an aqueous solution using a tea bag containing rooibos tea and sodium carbonate (Na ₂ CO ₃ ) inside the tea bag can be stored anytime and anywhere. Drinking water containing high-concentration active hydrogen that does not change with time can be stored anytime and anywhere, and the amount of active hydrogen (negative ions) that does not change with time is high. As with the Hunza Kingdom, the concentration of active hydrogen (negative ions) under the conditions necessary to make the average lifespan 100 years or older is high, and the redox potential is negative. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcohol drinks characterized by providing 50, or -100, -150, or -200 and large aqueous solutions as drinking water Water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). In a tea bag or other container containing rooibos tea, sodium hydrogen carbonate (NaHCO ₃ ), sodium carbonate (Na ₂ CO ₃ ), or other The inside of a tea cup or other container containing hot or boiling water in a tea bag containing an alkaline substance (hereinafter abbreviated as sodium carbonate (Na ₂ CO ₃ )) together The active hydrogen that acts to neutralize and remove the active oxygen generated in the human body by alkali extraction with Suti and tea bags are placed sodium carbonate (Na 2 _{CO 3),} or rooibos and sodium carbonate are placed in the interior of the other container (Na 2 _{CO 3)} by a chemical reaction, for example, active hydrogen content A food raw material, a food, characterized in that drinking water is an aqueous solution generated in hot water boiling active hydrogen having an acidic reduction potential of (minus ion) of -100 to -200 or more, or cold water, Health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). Sodium carbonate (Na ₂ CO ₃ ), sodium hydrogen carbonate (NaHCO ₃ ), potassium hydroxide (KOH), sodium hydroxide (NaOH), or ammonium hydroxide Together with rooibos tea that contains (NH ₄ OH), ammonia (NH ₃ ), or other alkaline substance (hereinafter abbreviated as sodium carbonate (Na ₂ CO ₃ )) inside the tea bag put sodium carbonate _(Na 2 CO ₃₎ in the interior of the tea bag, the oxidation-reduction potential (ORP) For the purpose of reducing, put sodium carbonate (Na 2 _{CO 3)} with inside rooibos tea bag, lowering the oxidation-reduction potential (ORP), erasability of active oxygen reducing power is strong ROBOSTY and carbonic acid having a high reducing power, for example, a redox potential (ORP) of −50 mv, −100 mv, −150 mv, or −200 mv or more, or an aqueous solution or drinking water containing drinking water Sodium (Na ₂ CO ₃ ) is used to lower the redox potential (ORP), and the aqueous solution or drinking water with the highest reducing power is put together with rooibos tea and sodium carbonate (Na ₂ CO ₃ ). was used tea bag, sodium sodium carbonate are placed in a tea bag (Na 2 _{CO 3)} free, or is divergence Io (Na ^+), or hydrogen ions (H ⁺⁾ by dissolving in an aqueous solution, to lower the oxidation-reduction potential (ORP), reducing power like groundwater Hunza kingdom, there is a strong reducing power aqueous Food raw materials, foods and health foods characterized by alkaline extraction of drinking water using rooibos tea and sodium carbonate (Na ₂ CO ₃ ) conveniently in tea bags anytime and anywhere , Drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). Hydrogen ions (H ⁺ ) contained in rooibos tea leaves such as tea leaves such as vitamin C contained in rooibos tea leaves or polyphenols and hydrogen ions (H ⁺ ) Is covalently bonded, sodium hydrogen carbonate (Na ₂ CO ₃ ) or the like is used to release or separate hydrogen ions (H ⁺ ) contained in the leaves of this rooibos tea from vitamin C or polyphenol. For example, a heated aqueous solution having a PH concentration of 8.5 or more, or cold water using vitamin C, Alternatively, active hydrogen ions (H ⁺ ) having a high concentration of active hydrogen (negative ions) and a negative oxidation-reduction potential due to liberation or separation of hydrogen ions (H ⁺ ) covalently bonded to polyphenols or the like A food raw material and food, characterized in that an aqueous solution or a drinking water in which water is dissolved or drinkable water can be easily released or separated from the leaves of rooibos anytime and anywhere , Health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, tay pack raw material, tay pack, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangrove, or pine nut shell, or green tea, or tea, or brown rice tea, or oolong tea, or puer tea, or other herbal tea or coffee (hereinafter abbreviated as rooibos tea). ), For example, put 0.05 g or more of sodium carbonate (Na ₂ CO ₃ ) or about 0.2 g together in a tea bag containing 1.0 g or more of rooibos tea. When the tea bag which made the tea bag is put in the tea cup containing about 220 ml of boiling hot water and the amount of active hydrogen (negative ions) in the aqueous solution inside the tea cup is measured After a few minutes after the tea bag is first placed in the hot water, the redox potential (ORP) is a reducing power of around -140 mV. The oxidation-reduction potential (ORP) after 30 minutes decreases to around −95 mV, and the oxidation-reduction potential (ORP) after 1 hour decreases to around +5 mV. Even if active hydrogen ions (H ⁺ ) are generated inside the tea cup using a tea bag containing rooibos tea and sodium carbonate (Na ₂ CO ₃ ), the active hydrogen is within one hour. The above experimental results show that the ions (H ⁺ ) evaporate from the aqueous solution inside the tea cup and disappear. From the above experimental results, water of “Tracote”, which is a miracle water in Mexico. Or “Nordenau” water, which is a miracle water in Germany, or “active hydrogen water” containing a large amount of “active hydrogen” similar to the miracle water in the Hunza kingdom. The successful be generated using chromatography and sodium carbonate (Na 2 _{CO 3),} the above experimental results show, also to effectively drinking, it is to drink within 30 minutes From the above experimental results, which proved to be the most effective, rooibos containing hydrogen atoms (active hydrogen) contained in tea leaves such as rooibos tea or other plant leaves inside tea bags Using a tea bag containing tea leaves such as tea or plant leaves and sodium carbonate (Na ₂ CO ₃ ), active hydrogen (in a tea cup containing hot or cold water) ( To drink active hydrogen water, which is an aqueous solution containing a large amount of active hydrogen (hydrogen atoms) liberated or separated from hydrogen atoms), use the tea bag described above inside the tea cup. It is found that drinking around 30 minutes after the alkali extraction or within a maximum of 1 hour generates active hydrogen water containing active hydrogen that has the strongest action of eliminating active oxygen. From the above experimental results, it is possible to judge the water of “Trachote”, which is a miracle water in Mexico that contains a large amount of active hydrogen, or the water of “Nordenau”, which is a miracle water in Germany. Or anytime, anywhere to create active hydrogen water containing active hydrogen that is exactly the same as the amount of active hydrogen (negative ions) contained in the miracle water of the Kingdom of Hunza for drinking and create active hydrogen water containing active hydrogen, originating active hydrogen water containing active hydrogen using a tea bag placed rooibos and sodium carbonate (Na 2 _{CO 3)} together Otherwise, the active hydrogen has the very light atomic number 1. Therefore, as can be seen from the above experimental results, the active hydrogen evaporates around 30 minutes from the aqueous solution in which the active hydrogen was generated. Use tea bags with tea leaves such as rooibos tea or other plant leaves and alkaline substances such as sodium carbonate (Na ₂ CO ₃ ) together inside the tea bag. In addition to generating active hydrogen in the aqueous solution, tea bags are used because it is not possible to drink drinking water that has generated the active hydrogen within 30 minutes, which is the freshest and most effective in eliminating active oxygen. Thus, active hydrogen water containing active hydrogen can be easily provided. In addition, the aqueous solution used in the experiment to inactivate the hepatitis virus using the hepatitis virus infected by the mouse, which was conducted at the National Institute of Infectious Diseases shown in the graph (1), was also used with rooibos tea and sodium carbonate ( If a tea bag containing Na ₂ CO ₃ ) is immersed in a boiling tea cup for 30 minutes and an aqueous solution in which active hydrogen is generated is used, the hepatitis virus that infects rats is prevented. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic beverages, shochu, which proved that active hydrogen can also inactivate viruses from being able to activate Raw material, tea bag raw material, tea bag, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, rooibos tea, or mangroves, or pine nut shells, or green tea, or black tea, or barley tea, or barley tea, or brown rice tea, or oolong tea, or tea such as pear tea, or other herbal teas, or coffee, Or a well-dried oak tree chip, or cherry tree chip, or apple tree chip, or beech tree chip, or oak tree chip, or walnut tree chip, or hickory Chips of wood, or chips of maple, or chips of mixed trees such as birch, cherry, beech, oak, maple, or birch, or other trees Chips, green tea, black tea, chlorella, chlorella tea, Tochu tea, barley tea, brown rice tea, coffee, cocoa, octagonal fine powder, pine nut powder, mangrove trunk and branch and leaf powder, Tea of the family Rosaceae belonging to the family Raspberry genus (Tencha), yellow tea (Pei Chi tea), cat claws (Cats crow tea), Kazura tea (Kajikazura tea), Tahibo tea native to the back of the Amazon, native to Africa Rooibos tea, eye-drop tree tea (Megurinoki tea), Indian native gymnema tea, Rafu hemp tea, cod leaf tea, ipeloscio tea, plum
Turmeric tea, carrot tea, dokudami tea, tomorrow leaf tea (Ashitaba tea), candy tea tea (Achacha tea), aloe tea, ginkgo leaf tea, oolong tea, psyllium tea, oyster leaf tea, garcinia tea, gymnema tea, guava tea , Rich tea, Kumazasa tea, mulberry leaf tea, sijuum tea, perilla leaf tea, jasmine tea, sugina tea, buckwheat tea, tabebuiya tea, cod leaf tea, ten tea, dokudami tea, herbal tea, ning tea (ninhong tea) ),
-Tea such as potash tea, mugwort tea, lacanka tea, raffma tea, longi tea (longines tea), or ginseng, licorice, ground yellow, juju, or Chinese medicine meds Homecoming, Shakuyaku, Ginger, Koboku, Rokujou, or Bushi, Hange, Daihuang, Annin ) (Hereinafter abbreviated as grass root bark, or herbal medicine, or rooibos tea), for example, sodium bicarbonate (NaHCO ₃ ) inside tea bag containing 4.0 g rooibos tea, or sodium carbonate _(Na 2 _CO 3), or other alkaline substance (hereinafter, abbreviated, sodium carbonate _(Na 2 CO ₃₎ to) is sodium carbonate (Na The teabag the CO ₃₎ have created a tea bag containing the approximately 0.2g together, putting tea bag hot water of boiling inside the tea cup are putting about 220 ml, tea cups alkaline extraction When the amount of active hydrogen (negative ions) in the aqueous solution inside is measured, it is 30 minutes that the redox potential (ORP) is about -140 mV after a few minutes after the tea bag is first placed in the hot water. The oxidation-reduction potential (ORP) after a minute decreases to about -95 mv, and the oxidation-reduction potential (ORP) after one hour decreases to about +5 mv. In addition, as a control, a tea bag containing only 4.0 g of rooibos tea was used, and under the same conditions as above, rooibos tea was placed inside a tea cup containing about 220 ml of boiling hot water. The extraction / reduction potential (ORP) of the rooibos tea-extracted liquid extracted from hot water with a tea bag containing only 4.0 g of +25 mV was +25 mV. What the above experimental results mean is that active hydrogen ions (H ⁺ ) are generated inside the tea cup using a tea bag containing rooibos tea and sodium carbonate (Na ₂ CO ₃ ). Even if it is generated, the above experimental results show that the active hydrogen ions (H ⁺ ) evaporate from the aqueous solution inside the tea cup and disappear within a time of about 1 hour. From the results, it contains a lot of "active hydrogen" similar to the water of "Tracote", the water of Mexico's miracle, or the water of "Nordenau", the water of Germany's miracle. The above experimental results show that the “active hydrogen water” was successfully generated using rooibos tea and sodium carbonate (Na ₂ CO ₃ ) inside the tea cup, and effectively Drinking In order to do this, it was found that drinking within 30 minutes is the most effective. From the above experimental results, the hydrogen atoms contained in the leaves of tea leaves such as rooibos tea or other plants ( Hot tea or cold water using tea leaves such as rooibos tea containing active hydrogen) in tea bags, or tea bags containing plant leaves and sodium carbonate (Na ₂ CO ₃ ) together To drink active hydrogen water, which is an aqueous solution containing a large amount of active hydrogen (hydrogen atoms) released or separated from active hydrogen (hydrogen atoms) inside the tea cup containing Drinking within 30 minutes, or at most within 1 hour after alkali extraction using the tea bag described above inside, has the strongest effect of eliminating active oxygen It can be judged from the above experimental results that it has been found that active hydrogen water containing active hydrogen is generated. The water of “Tracote”, which is a miracle water in Mexico that contains a large amount of active hydrogen, can be judged. Or active water containing exactly the same amount of active hydrogen (negative ions) as the water of “Nordenau”, the water of Germany ’s miracle, or the water of the miracle of the Kingdom of Hunza To make and drink active hydrogen water containing active hydrogen most effectively anytime, anywhere, tea bag with rooibos tea and sodium carbonate (Na ₂ CO ₃ ) together If active hydrogen water containing active hydrogen is not generated using, the active hydrogen is the atom with the lightest atomic number, and as can be seen from the above experimental results, At 30 minutes before and after the in, the active hydrogen would escape by evaporation, tea leaf tea such as Rooibos, or alkaline substances such as leaves and sodium carbonate other plants (Na 2 _{CO 3)} Beverages that generate active hydrogen within 30 minutes, which is the freshest and most effective in eliminating active oxygen, in addition to generating active hydrogen in an aqueous solution using a tea bag placed inside the bag Since water cannot be drunk, the active hydrogen water containing active hydrogen can be simply provided using a tea bag. In addition, the aqueous solution used in the experiment to inactivate the hepatitis virus using the hepatitis virus infected by the mouse, which was conducted at the National Institute of Infectious Diseases shown in the graph (1), was also used with rooibos tea and sodium carbonate ( If a tea bag containing Na ₂ CO ₃ ) is immersed in a boiling tea cup for 30 minutes and an aqueous solution in which active hydrogen is generated is used, the hepatitis virus that infects rats is prevented. Food raw materials, foods, health foods, drinking water, drinking water raw materials, alcoholic beverages, shochu, which proved that active hydrogen can also inactivate viruses from being able to activate Raw material, tea bag raw material, tea bag, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

In addition, barley, roasted wheat (hereinafter referred to as roasted) barley tea, or cereals such as brown rice, white rice, rice bran, rice bran, for example, brown rice tea, or roasted soybeans, red beans, coffee beans For example, coffee or cocoa roasted cacao beans (hereinafter abbreviated as barley tea), for example, an alkaline substance (hereinafter abbreviated as carbonic acid) in a tea bag containing 4.0 g of barley tea. A tea bag made with sodium (Na ₂ CO ₃ ) and sodium carbonate (Na ₂ CO ₃ ) of about 0.3 together with a tea bag containing about 220 ml of boiling hot water. When a tea bag is placed inside the cup and the amount of active hydrogen (negative ions) in the aqueous solution obtained by alkali extraction using the tea bag inside the tea cup is measured, the redox potential ( RP) has a reducing power of around −331 mV, while using a tea bag containing only 4.0 g of barley tea inside the tea bag as a control, the boiling water is boiling under the same conditions as above. It was found that the redox potential (ORP) obtained by extracting hot water inside a tea cup containing about 220 ml of the tea was a reducing power of around -62 mV. It can be judged from the above experimental results that water of “Trachote”, which is a miracle water in Mexico containing a large amount of active hydrogen, or “Nordenau” water, which is a miracle water in Germany, or Hunza The amount of active hydrogen contained in the miracle water of the kingdom (negative ion) and the amount of active hydrogen contained in the miracle water or the amount of active hydrogen contained in the miracle water (negative ion) By creating a tea bag containing barley tea and sodium carbonate (Na ₂ CO ₃ ) in the tea bag together with the drinking water containing the above active hydrogen, it easily contains a large amount of active hydrogen. The present invention is characterized by the fact that it is possible to generate drinking water that is contained, and that active hydrogen water containing a large amount of active hydrogen can be drunk at any time and anywhere. Also, in the case of coffee, in the same manner as above, a tea bag in which 6.0 g of coffee powder and about 0.3 g of sodium carbonate (Na ₂ CO ₃ ) are put together is placed inside the tea bag. It was found that the extracted redox potential (ORP) has a reducing power of around −153 mv, whereas control has a reducing power of around −10 mv. From the above, it was discovered that active hydrogen with the effect of eliminating active hydrogen can be easily generated in large quantities using tea bags, and this is the main lifestyle-related disease that causes human illness. It has been reported that 90% of diseases such as are caused by active oxygen. For example, active oxygen has a strong oxidizing power and an oxidation-reduction potential (ORP) of +800 mV or higher, and the mechanism of cancer development is that active oxygen damages oncogenes and causes mutations, triggering carcinogenesis, etc. , By eliminating active oxygen, active hydrogen is a lifestyle-related disease, cancer, arteriosclerosis, ischemic heart disease, cerebral ischemia, dementia, cataract, emphysema, inflammation, ulcerative colitis, aging, Prevention, treatment of life-style related diseases caused by active oxygen such as diabetes, allergy, atopy, asthma, skin diseases, respiratory diseases, arthritis, etc., treatment of patients with viral diseases due to antiviral effects, and AIDS patients It is said that it is effective to drink an aqueous solution containing active hydrogen for the treatment of intractable diseases such as patients with viral hepatitis and patients with other viral diseases. Are, an alkaline substance has put the interior of the tea bag to generate active hydrogen using, for example, sodium carbonate (Na 2 _{CO 3),} and the easily alkaline extraction, barley, brown rice Extraction of active hydrogen that contains and covalently binds active hydrogen that contains cereals such as coffee beans, beans such as coffee beans, or leaves, trunks, peels, and roots of plants such as tea As a result, active hydrogen is released or separated to generate active hydrogen, food raw material, food, health food, drinking water, drinking water raw material, alcoholic drinking water, shochu raw material, Tea bag raw material, tea bag, feed raw material, pharmaceutical raw material, pharmaceutical, alcohol raw material, and production method thereof.

  In addition, 11 types of catechins shown in Table 3 (hereinafter abbreviated as epigallocatechin gallate (EGCg) or catechin (EGCg) as catechins of typical examples are influenza viruses and AIDS viruses) It has been found that viruses, or bacteria, can be very inactivated inside a test tube (in vitro) against various miscellaneous viruses such as HCV, or papilloma virus, or bacteria such as MRSA. Since catechins are easily degraded in the intestinal tract, the digestive tract, even if catechin is administered orally, 99% or more of the active ingredients of catechin readily decompose in the intestinal tract. Since there is a drawback that it is not absorbed, development of drugs with oral administration of catechin is currently underway The current situation is that catechin, which is a disadvantage of catechin, has an unstable chemical structure that is easily degraded in the digestive tract. In order to change to a chemical structure, an enzyme lipase is used as a component of catechin, a fatty acid is introduced into epigallocatechin gallate, which is a component of catechin, or a fatty acid is introduced into catechin to form a new epigallocatechin gallate compound, or When a catechin compound (hereinafter abbreviated as epigallocatechin gallate compound, or epigallocatechin derivative, or catechin compound or catechin derivative) is formed, the catechin derivative changes to a substance that does not decompose in the digestive tract. Therefore, the name of the disease intended for oral administration is malaria, sleeping sickness, AIDS, hepatitis C, adult white blood Development of drugs that can be administered orally, such as tablets or capsules formed using catechin derivatives intended for oral administration for the purpose of treating diseases and infections such as influenza I was able to do it.

  Furthermore, for the purpose of developing a drug for the purpose of oral administration, intraperitoneal administration, or intravenous administration of catechin as described above, the unstable chemical structure of catechin, which is a drawback of catechin In order to change the chemical structure of catechin to a chemically stable chemical structure for the purpose of changing the properties of catechins, the following ▲ 1 ▼ , (2), (3), (4), (5), and (6) are caused to undergo a condensation reaction, which is a chemical reaction, and form a catechin derivative to form a catechin derivative. Since the chemical structure is chemically stable, it is possible to form a drug for oral administration, intraperitoneal administration, or intravenous administration of catechin.

  As (1), catechin and iron are subjected to a condensation reaction to form a new catechin derivative.

  As (2), catechin and caffeine are subjected to a condensation reaction to form a new catechin derivative.

  As (3), catechin and tannin are subjected to a condensation reaction to form a new catechin derivative.

  As (4), a catechin derivative, which is a new compound, is formed by a condensation reaction of catechin and a fatty acid.

  As (5), a catechin derivative, which is a new compound, is formed by a condensation reaction between catechin and protein, sugar chain, lipid and the like.

  As for (6), the causative virus causing cervical cancer and endometrial cancer (hereinafter abbreviated as cervical cancer) is papillomavirus (HPV) (hereinafter abbreviated as HPV). . The purpose of research and development on the development of the three types of treatment methods (a), (b), and (c) described below as treatment methods for treating cervical cancer that develops due to HPV And

  As for ▲ a ▼, epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) and palm oil or vagina used by women by mixing catechin and hard hat oil as the main drug By developing a suppository and inserting a vaginal suppository into the vagina of a woman with cervical cancer and applying catechin on the surface of the uterus, HPV, the virus causing cervical cancer, is killed. The purpose of this study is to develop a therapeutic method for treating cervical cancer.

  As for (b), catechin is easily decomposed in the intestinal tract, which is a digestive organ, for the purpose of developing an internal medicine intended for oral administration for treating cervical cancer. Therefore, in order to change the unstable chemical structure of catechin to a chemically stable chemical structure, for example, a catechin and a fatty acid are subjected to a condensation reaction using an enzyme lipase and chemically stabilized with catechin. A catechin derivative condensed with a fatty acid, or a catechin compound (hereinafter abbreviated as catechin derivative) is synthesized, and the catechin derivative is absorbed into the blood from the intestinal tract of a female patient who has developed cervical cancer. The purpose of the research and development is to develop a therapeutic means for treating cervical cancer for the purpose of killing HPV dissolved in blood and HPV proliferating in the uterus.

  As for ▲ c ▼, HPV, which is a causative virus for developing cervical cancer, can be obtained by direct intraperitoneal administration of catechin as a single catechin or intravenous administration of catechin as a single catechin. It aims at killing HPV using the effect that catechin inactivates HPV using HPV dissolved in blood using injected catechin and HPV growing in uterus. The purpose of this study is to develop a therapeutic method for treating cervical cancer.

  In addition to the resistant malaria parasites shown in Table 3, a combination of catechin and artesunate or catechin and chloroquine in combination with two drugs each inactivated the resistant malaria parasite in recent years. The existing drugs oseltamivir (hereinafter abbreviated as Tamiflu), xanavir (hereinafter abbreviated as Relenza), and simmetrel (hereinafter abbreviated as amantadine) The mechanism of action of Tamiflu and Relenza as two types of drugs suppresses the action of neuraminidase, a protein necessary for the virus that has grown inside the cell to go outside the cell. Because Tamiflu and Relenza are the same drugs, they are exactly the same drug. The action mechanism of the effect of Amandadin, which is another existing drug, as a drug is the action that suppresses the action of M2, which is a necessary protein immediately after the virus goes out of the cell, so Amandadine is Tamiflu and Relenza It is a drug that is different from the action effect. In addition, the headquarters of Toyama Chemical in Tokyo is conducting clinical trials, and the mechanism of action of T-705 as an anti-influenza drug is the mechanism of action of the polymerase that is the protein that constitutes the influenza virus gene. Since the function of the polymerase is suppressed inside the cell, the replication of the influenza virus itself is suppressed, and there is an advantage that a resistant influenza virus cannot be produced. As described above, Tamiflu is the mechanism of action of four types of therapeutic drugs for influenza viruses, including T-705, which is currently in Phase 2 clinical trials, with three existing drugs, and currently under Phase 2 clinical trials. , And Relenza suppress the action of a protein named neuraminidase. The mechanism of action of amandadin as a drug suppresses the action of the protein named M2. The effect of the mechanism of action of T-705 as a drug suppresses the function of the protein named polymerase. Although there is a difference between the above four types of influenza drugs that suppress the protein action outside the cell or the protein inside the cell, the common matter is to suppress the protein action. There are four influenza cases, including the three types of influenza drugs described above and one of the clinical drugs at the clinical trial stage. It is the biggest feature of a therapeutic drug. The feature of these four influenza drugs is the greatest characteristic common to the four influenza drugs described above that suppresses the action of the proteins constituting the influenza virus. The relationship between flukins and catechins, which is explained above, is a total of 4 flu medicines, including 3 existing flu medicines and 1 clinical trial. The following (1) and (2) Described in ▼, (3) and (4).

  As for (1), three types of influenza drugs, Tamiflu, Relenza, and Amandadine, which are described above and aimed at suppressing the action of influenza virus, are being developed in clinical trials. The relationship between a total of 4 flu drugs and one catechin, including one T-705, is exactly the same as the active ingredient of astringent astringent as an active ingredient of catechin, and there are various properties of catechin. The greatest feature of catechins is that the condensation reaction with miscellaneous proteins, sugar chains, lipids, and fatty acids is strong and has a strong property of forming a condensation bond. In particular, catechin has a strong property of causing a condensation reaction with all proteins that are variously different from proteins and has a strong condensation bond.

  As for (2), as for the action effect of catechin as a drug in the past, it has been found that in the experiment inside the test tube, influenza virus, AIDS virus, or other various miscellaneous viruses are inactivated. Was. However, since catechin has an unstable chemical structure, catechin is decomposed in the intestinal tract of the digestive tract even if catechin alone is administered orally with catechin alone. Was thought to be a non-occurring substance. In addition, since catechin is strongly condensed and bonded to a protein, toxicity is generated in the living body. Therefore, catechin is not administered intraperitoneally or catechin is administered intravenously at all.

  As for (3), when catechin alone with only catechin is administered to the human body, catechin is injected into the abdominal cavity of the human body using a syringe so that it can be judged from the experimental results in Table 3. If catechin is administered directly into the peritoneal cavity or administered intravenously using a syringe into the human body, the catechin is inherently retained without being degraded in the intestinal tract of the digestive tract. It is possible to exert the action and effect as a drug. The experimental results in Table 3 show that. However, as can be seen from the experimental results in Table 3, all mice died when 500 mg of catechin per kg was administered. However, it can be said that it was a great discovery that it was found that administration of 50 mg of catechin per Kg did not kill the mice. The fact that catechin was successfully inactivated using 50 mg / kg of catechin and that catechin was effective against malaria was also a great discovery. From this, catechin is directly administered intraperitoneally as catechin, or catechin is directly administered intravenously, AIDS virus, hepatitis C virus, influenza virus, herpes virus, papilloma virus, adult leukemia virus, The development of therapeutics for infectious diseases such as Trypanosoma protozoa, resistant Spirochetaparida, resistant Mycobacterium tuberculosis, and malaria (hereinafter abbreviated as infectious disease) can be performed using catechins. It can be said that this is a great discovery in the development of therapeutic methods aimed at eradicating future infectious diseases.

  As for (4), since catechin is unstable in chemical structure, it is easily decomposed in the intestinal tract of the digestive tract, so existing antibiotics, pharmaceuticals, and chemicals, for example, are currently used with resistance. Antibiotics such as penicillin, streptomycin, artemisinin (also known as artesunate), quinine, chloroquine, Tamiflu, Relenza, and amandadine (hereinafter abbreviated as typical examples, penicillin or artemisinin) A catechin derivative, or a regenerated penicillin, or a regenerated penicillin derivative, or a regenerated artemisinin, or an artemisinin derivative (hereinafter abbreviated as a catechin derivative, or Regenerated penicillin or penicillin derivative or re- Regenerating artemisinin, or regenerated artemisinin, or artemisinin derivative) to form a catechin derivative, or regenerated penicillin, or penicillin derivative, or regenerated artemisinin, or artemisinin derivative, which has a chemical structure that does not allow new resistance, The unstable chemical structure of catechin becomes a chemically stable chemical structure, and the chemical structure of catechin is chemically maintained while maintaining the original properties of catechin, the original properties of penicillin, or the original properties of artemisinin. Since it stabilizes, the catechin is not decomposed in the intestinal tract of the digestive tract even if it is administered orally. In addition, catechin derivatives, regenerated penicillin, or penicillin derivatives, or regenerated artemisinin, or artemisinin derivatives may be administered intraperitoneally and intravenously as a means of administration other than oral administration.

In addition, the purpose is to develop a very simple and effective treatment method that is extremely inexpensive, has no side effects, and has no side effects, and is infected with a highly toxic influenza virus such as H5N1. When the influenza virus is orally administered epigallocatechin gallate (EGCg) or other catechins (hereinafter abbreviated as catechins), the chemical structure of catechins is unstable. The chemical structure has the drawback of being easily degraded in the intestinal tract, the digestive organ. Catechin is a catechin that is said to have strong antiviral, antibacterial, or anticancer effects in vitro. However, catechin has a disadvantage that its chemical structure is unstable and is easily degraded in the intestine. At present, it has not been applied to pharmaceuticals. Therefore, for the purpose of avoiding the degradation of catechin in the intestinal tract, the digestive organ, which is a disadvantage of catechin, the catechin is bypassed through the intestinal tract, the digestive organ, and avoids the human intestinal tract to the human body. For the purpose of direct administration, catechin is directly administered intraperitoneally, or catechin is directly administered intravenously to dissolve in the blood and float in the organs Treatment of patients with influenza who are infected with a highly toxic influenza virus such as H5N1 by injecting flu virus into the blood and directly injecting catechin into the blood or intraperitoneally administering catechin The purpose is to conduct research and development for the purpose of research and development of treatment methods for influenza patients.
In addition, by direct intraperitoneal administration of catechin or intravenous administration of catechin directly, the disease develops due to trypanosomiasis, the disease name is sleep disease, or the disease name is Nagana disease, or malaria parasite The disease name is malaria, or cancer cells are killed, or cancer cells are killed in the blood.

In addition, as described above, as a therapeutic means for injecting catechin directly into the human body without passing through the intestinal tract that is the digestive organ of the human body, As a method of use as a treatment means other than patients with avian influenza, such as the highly toxic H5N1 type, which is directly administered intravenously and explained above, the human body is infected, catechin As a therapeutic means shown in the following (a), (b), (c), (d) and (e) by direct intraperitoneal administration or intravenous administration of catechin directly There is a usage method.
As (a), there is a utilization method as a treatment means for chickens infected with avian influenza virus whose disease name is avian influenza, such as highly toxic H5N1 type.
As (b), there is a method of use as a treatment method for sleep disease whose disease name is caused by infection of a human being caused by Trypanosoma protozoa.
As for (c), there is a method of using as a means of treating Nagana disease whose disease name is caused by infection of livestock such as cattle, horses, goats, etc. due to Trypanosoma protozoa.
As (d), there is a method in which the name of a disease that develops due to a malaria parasite is used as a means of treating malaria.
Examples of (e) include the use of cancer cells as a means of cancer treatment, in which cancer cells are killed or cancer cells are killed in blood.
In conclusion, the treatment means shown in (a), (b), (c), (d) and (e) above are used. ▲ a ▼ ▲ b ▼ ▲ c ▼ ▲ d ▼ ▲ f ▼

  In addition, catechin as a single catechin, or as a therapeutic means for the treatment of influenza patients with catechin as the main ingredient, oral administration, which is an internal medicine for the purpose of treating simple and inexpensive treatment of influenza patients, It is an internal medicine intended to treat influenza patients with the main component of catechin as the target.

  Moreover, since catechin is a chemical substance having a chemically unstable chemical structure, catechin is a substance that is easily decomposed in the intestinal tract, which is a digestive organ. Therefore, for example, by using an enzyme lipase, a fatty acid is introduced into epigallocatechin gallate (EGCg), which is the main main component of catechin, or other catechin, to create a catechin compound having a new chemical structure, Research and development of oral medicines for oral administration for the treatment of influenza patients, or pharmaceuticals for intraperitoneal or intravenous administration were conducted.

  In addition, there are currently three types of medicines, Tamiflu, Relenza, and Amantadine, which are existing drugs for oral administration, with the disease name as a treatment for influenza. I am doing. However, Tamiflu, Relenza, and Amantadine explained above are all in the state where resistant influenza virus strains are completely produced, or resistant influenza virus strains are appearing. In the near future, it may be considered that the effects of the three types of influenza therapeutic agents, Tamiflu, Relenza, and Amantadine described above, will be halved or completely disappear in the near future. Therefore, as a solution, the research and development shown in the following (a), (b), (c), (d), and (e) are performed to obtain regenerated Tamiflu, regenerated relensa, and regenerated amantadine.

  As (a), a condensed reaction is caused between catechin and Tamiflu which are unstable in chemical structure and easily undergo a condensation reaction to form a regenerated Tamiflu which is a new Tamiflu.

  Further, as (b), a condensation reaction is caused between catechin and rerenza to form a regenerated rerenza which is a new rerenza.

  As for (c), catechin and amantadine are caused to undergo a condensation reaction to form regenerated amantadine, which is a new amantadine.

  Furthermore, as (d), four types of catechin, Tamiflu, Relenza, and amantadine are mixed to cause a condensation reaction centering on three types of medicine and catechin to form a mixture of four types of influenza drugs. Therefore, existing influenza drugs that have emerged against existing Tamiflu, Relenza, amantadine, or existing medicines that have half the effect as pharmaceuticals in the middle of the emergence of resistant influenza virus strains In the future, Tamiflu, or Relenza, or Amantadine, a Tamiflu derivative, or a complex chemical structure in which resistant influenza virus strains cannot emerge using catechin in the future, By changing the Relenza derivative or Amantadine derivative, Influenza virus, such as N1 type, or resistant influenza virus strains to a deal aimed, disease name is a means of treating influenza patients.

  As for e, the above-described method for taking Tamiflu and amantadine is a tablet or powdered medicine intended for oral administration, and the disease name is a medicine intended for the treatment of influenza. Relenza is a drug that is inhaled in powder form and whose name is intended to treat influenza. When Tamiflu, Amantadine, and Relenza (hereinafter referred to as Tamiflu) are taken orally or nasally, catechins are taken together with catechins that are completely different from nasal administration. Even if catechin is administered by intraperitoneal administration or intravenous administration, which is completely different from the method of taking catechin, catechin and Tamiflu cause a condensation reaction in the blood of the human body, catechin derivatives, or Tamiflu derivatives, Alternatively, by becoming an amantadine derivative or a rerenza derivative, the disease name is intended to avoid influenza virus strains resistant to Tamiflu, amantadine, and rerenza, and is a therapeutic means for patients with influenza.

  Furthermore, by using an enzyme lipase for catechin as described above, fatty acid is introduced into epigallocatechin gallate (EGCg), which is a component of catechin, or other catechin (hereinafter abbreviated as catechin). When a new catechin compound (hereinafter abbreviated as a catechin derivative) is synthesized, the catechin derivative improves the permeability of the cell membrane. Therefore, compared to conventional catechins, catechin derivatives introduced with fatty acids are AIDS virus (HIV). ), Hepatitis C virus (HCV), herpes virus, influenza virus, trypanosoma protozoa, spirochete parida protozoa, and malaria protozoa (hereinafter abbreviated as infectious diseases) are more strongly inactivated or killed. Become. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means whose disease name is intended to treat influenza.

  Catechin extracted from tea catechins and purified using catechin as the main raw material is a substance that is easily degraded in the intestinal tract of the digestive tract. However, catechin extracted from tea is absorbed in the intestine and into the blood. Although it is a substance that dissolves, for the purpose of further absorbing catechins in the intestinal tract, catechin derivatives in which fatty acids are introduced into catechins using enzyme lipase and catechins pass through cell membranes or protect bacteria. In the blood in the intestinal tract, the permeability of the bacterial membrane that is the epidermis of the bacteria, the permeability of the envelope membrane that is the epidermis of the virus protecting the nucleic acid of the virus, or the permeability of the cancer cell membrane Compared with conventional catechins, the efficiency of dissolution is further improved, so that the anticancer effect of catechins, the antibacterial effect of catechins, or Although the antiviral activity of quinchin is stronger than that of conventional catechins, catechin derivatives in which fatty acids are introduced into conventional catechins are even stronger. The catechin derivative into which fatty acids have been introduced is used in the research and development of the therapeutic means, and the therapeutic name is intended to treat infectious diseases such as influenza.

  Furthermore, the treatment method for herpes simplex and herpes zoster patients whose herpes virus causes herpes simplex virus infection is extremely inexpensive, has no side effects, and is extremely simple and effective. To develop herpesvirus, epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) is directly administered intraperitoneally, or catechin is directly administered intravenously. Infection with herpes virus by direct injection of catechin into the blood with herpes virus dissolved in the blood and suspended in the blood or herpes virus growing in cells As a treatment method for patients with herpes simplex herpes simplex virus infection and herpes zoster.

  In addition, as a treatment method for herpes simplex herpes simplex virus infection and herpes zoster as described above, Gerrode Elion of Burroughs Wellness Laboratories, the antiviral agent acyclovir is a specific medicine. Has been developed. However, a herpesvirus strain resistant to acyclovir has already emerged. For the purpose of avoiding this herpesvirus strain resistant to acyclovir, acyclovir and catechin are condensed in the human body by using acyclovir and catechin together, or catechin is mixed with acyclovir and catechin. And acyclovir are caused to undergo a condensation reaction to produce regenerated acyclovir to be a therapeutic means for inactivating or killing resistant herpesvirus strains.

  Furthermore, artesunate whose disease name is malaria is currently not used as a therapeutic drug due to the emergence of resistant malaria parasites, or its effectiveness as a drug has been reduced (artemisinin is a hydrophobic substance. (Artesunate is a hydrophilic substance that dissolves artemisinin in water), quinine, or a drug that treats malaria with the name of malaria and has some side effects, but is currently the cheapest drug. As a therapeutic drug, chloroquine, which is rarely used as a therapeutic drug, is regenerated, and again used as a therapeutic means as a therapeutic drug for malaria.

  In addition, for the purpose of avoiding artesunate-resistant malaria parasites that are sensitive to artesunate_, epigallocatechin gallate (EGCg), or other catechins (hereinafter abbreviated as catechins) and artesunate in combination, Alternatively, catechin and artesunate are mixed and catechin and artesunate are condensed to create a compound similar to the new compound artesunate derivative, which is caused by an artesunate-resistant malaria parasite that is sensitive to artesunate. The treatment is aimed at treating malaria with the onset of disease.

  Furthermore, for the purpose of avoiding chloroquine-resistant malaria parasites that are sensitive to chloroquine, a new compound is produced by combining catechin and chloroquine or mixing catechin and chloroquine to cause condensation reaction between catechin and chloroquine. A compound similar to the chloroquine derivative is prepared and used as a therapeutic means for the treatment of malaria whose name is caused by a chloroquine-resistant malaria parasite that is sensitive to chloroquine.

  Moreover, it is set as the therapeutic means aiming at performing the treatment of the disease name malaria using a catechin using the catechin single-piece | unit demonstrated above.

  Furthermore, epigallocatechin gallate (EGCg), which is a component of catechin using the enzyme lipase described in (3), (4) and (5) above, or other catechin (hereinafter referred to as “catechin”). When a new catechin compound (hereinafter abbreviated as a catechin derivative) is synthesized by introducing a fatty acid into the catechin (abbreviated as catechin), the catechin derivative is improved in permeability through the cell membrane. In comparison, catechin derivatives into which fatty acids have been introduced have the activity to inactivate or kill AIDS virus (HIV), hepatitis C virus (HCV), herpes virus, influenza virus, trypanosoma protozoa, spirochete parida, and malaria protozoa However, it becomes stronger. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means for treating a disease whose name is malaria.

  The causative virus that causes cervical cancer and endometrial cancer (hereinafter abbreviated as cervical cancer) is papillomavirus (HPV) (hereinafter abbreviated as HPV). As therapeutic means for treating cervical cancer that develops due to HPV, there are three kinds of therapeutic means (a), (b), and (c) described below.

  Furthermore, as (a), epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) and palm oil or catechin and hard hat oil are used as a main drug. HPV is the causative virus of cervical cancer by developing a vaginal suppository and inserting catechin on the surface of the uterus by inserting the vaginal suppository into the vagina of a woman who has developed cervical cancer Is a therapeutic means for treating cervical cancer for the purpose of inactivating or killing.

  As (b), catechin was directly injected intraperitoneally or catechin was directly administered intravenously to cause HPV, which is a causative virus for developing cervical cancer, and catechin injected into blood. A cervical that aims to kill HPV using the effect of catechin inactivating HPV using HPV dissolved in blood and HHPV proliferating in the uterus A therapeutic means for treating cancer.

  Furthermore, for (c), catechin is easily decomposed in the intestinal tract, which is a digestive organ, for the purpose of developing an internal medicine intended for oral administration for treating cervical cancer. Therefore, for example, in order to change the unstable chemical structure of catechin to a chemically stable chemical structure, for example, a catechin and a fatty acid are chemically stabilized by a condensation reaction of catechin and a fatty acid. A synthetic catechin derivative or a catechin compound (hereinafter abbreviated as catechin derivative) for oral administration is synthesized and used in the digestive tract of a female patient developing cervical cancer. Cervical cancer for the purpose of inactivating or killing HPV dissolved in blood and HPV growing in uterus by absorbing catechin derivatives into blood from a certain intestinal tract Is a therapeutic means of treating.

  In addition, allicin, a substance contained in leeks, is said to be effective in preventing colds and having a disease name for influenza. The purpose of this cold prevention is to identify allicin, which is a substance contained in leeks whose disease name is said to be effective against influenza, and to identify compounds similar to allicin, and to conduct research and development on the synthesis of these compounds. .

  Furthermore, epigallocatechin gallate (EGCg), which is a component of catechin, or other catechins (hereinafter referred to as catechin for short) has an unstable chemical structure. This catechin has an unstable chemical structure, which is characterized by a condensation reaction with proteins, sugar chains, lipids, minerals, and other substances, resulting in a chemically stable catechin. It is a substance with remarkable properties. When this catechin is used by applying a chemical structure in which the chemical structure of catechin is chemically unstable, for example, it is a first-generation antibiotic that was developed in the past in the past, and it is resistant and has not been used in the past. On the formation of new catechin derivatives, catechin complexes, or catechin compounds (hereinafter abbreviated as catechin derivatives) by causing condensation reactions of antibiotics, pharmaceuticals, and chemicals with catechins For development purposes. For example, the current antibiotics penicillin, streptomycin, the antiviral agent acyclovir, artemisinin (also known as artesunate), quinine, chloroquine, Tamiflu, which are drugs that are currently resistant and not being used or are becoming resistant , Relenza, and amantadine (hereinafter abbreviated as a representative example, penicillin, or Tamiflu, or artemisinin, or chloroquine) and the like, and catechin are subjected to a condensation reaction, past penicillin that has developed conventional resistance, Or regenerate Tamiflu, Artemisinin, or Chloroquine into another compound to form a regenerated penicillin derivative, or a regenerated Tamiflu derivative, or a regenerated Artemisinin derivative, or a regenerated chloroquine derivative that has a chemical structure that cannot be renewed. And play.

In addition, the Chinese name containing artemisinin derivative (also known as artesunate) is yellow flower bud, and the Japanese name is xanthine, containing artemisinin derivative.
For the purpose of research and development regarding the comparison of the content of yellow flower pods containing artemisinin derivatives in each region that contains yellow flower pods cultivated in each region on the earth To do.

  Furthermore, it aims at research and development regarding to clarify why there is a big difference in the content of artemisinin derivatives contained in yellow flower buds that are cultivated in each region on the earth.

  In addition, a study on the correlation between the content of artemisinin derivatives contained in yellow flower buds and the reproductive status of anopheles mosquitoes that carry malaria parasites whose disease name infects malaria. For example, the yellow flower moth that provides sap to an anopheles mosquito contaminated with malaria parasites is a substance similar to the antibody in the animal world that aims to protect its own body. The purpose of the research and development is to elucidate the mechanism of whether or not yellow flower buds are producing artemisinin derivatives as substances that have exactly the same effects.

  In addition, catechins are used to inactivate Trypanosoma protozoa, which are pathogens for sleep diseases that cause illness in the human body and cattle, horses, goats, etc. Use as a means of treatment.

  In addition, using a mixture of catechin and artesunate (hereinafter abbreviated as artesunate complex) or a mixture of catechin and chloroquine (hereinafter abbreviated as chloroquine complex), pathogens of sleep disease and Nagana disease Trypanosoma protozoa are used as therapeutic means for inactivation using artesunate complex or chloroquine complex.

  Furthermore, by using an enzyme lipase for catechin as described above, fatty acid is introduced into epigallocatechin gallate (EGCg), which is a component of catechin, or other catechin (hereinafter abbreviated as catechin). When a new catechin compound (hereinafter abbreviated as a catechin derivative) is synthesized, the catechin derivative improves the permeability of the cell membrane. Compared with the conventional catechin, the catechin derivative introduced with a fatty acid is an AIDS virus ( The activity of inactivating or killing HIV), hepatitis C virus (HCV), herpes virus, influenza virus, trypanosoma protozoa, spirochete parida protozoa, and malaria protozoa becomes even stronger. A catechin derivative obtained by introducing a fatty acid into this catechin is used as a therapeutic means for the treatment of sleep disease and Nagana disease.

  In addition, to develop a very simple and effective treatment method for patients with hepatitis C virus (HCV) whose disease name is very inexpensive and has no side effects. Depending on the purpose, epigallocatechin gallate (EGCg) or other catechin (hereinafter abbreviated as catechin) is directly administered intraperitoneally as a means of treating patients with hepatitis C, or catechin is directly intravenous Injecting catechin into the blood directly by injecting HCV that has been dissolved and suspended in the blood and HCV proliferating in the organ into the blood In order to carry out research and development of a treatment method that directly kills HCV, animal experiments using chimpanzees infected with hepatitis C virus (HCV) Use as a means of treatment.

  Furthermore, for the purpose of developing a very simple and effective treatment means that is infected with AIDS virus (HIV), whose disease name is extremely cheap, no side effects, and has no side effects. As a treatment for AIDS patients, catechin is directly administered intraperitoneally, or catechin is directly administered intravenously, budding on the surface of free floating HIV or cells floating in the blood Research and development of therapeutic means for killing HIV directly in blood by injecting HIV in the blood or catechin directly into the blood. Therefore, animal experiments using rhesus monkeys infected with AIDS virus (HIV) or green monkeys are performed to treat AIDS patients.

In addition, regarding the treatment means for hepatitis C patients and the treatment means for AIDS patients described above, hepatitis C by directly administering intraperitoneal catechin, directly administering intravenous catechin, and Use as a treatment for AIDS patients.
Furthermore, for the purpose of treating hepatitis C patients and AIDS patients, therapeutic means for treating catechins by intraperitoneal administration or intravenous administration are expensive therapeutic means. Therefore, catechin is used as a medicine, and a therapeutic means aimed at treating hepatitis C patients and AIDS patients by simple and inexpensive oral administration.
In addition, it aims at the research and development of the oral medicine for the purpose of oral administration for the purpose of treating hepatitis C patients and AIDS patients as described above. Since catechin is a chemical substance with a chemically unstable chemical structure, catechin is a substance that is easily decomposed in the intestinal tract, which is the digestive organ. Therefore, for example, by using an enzyme lipase, a fatty acid is introduced into epigallocatechin gallate (EGCg), which is the main main component of catechin, or other catechin, to create a catechin compound having a new chemical structure, Therapeutic means intended for oral administration for the treatment of hepatitis C patients and AIDS patients.

  Furthermore, regarding the anti-influenza virus activity of catechin, the results of the experiment on the anti-influenza virus activity of catechin conducted by Prof. Masahiko Kurokawa of the Second Department of Biochemistry of Pharmaceutical Sciences, Kyushu University of Health and Welfare and the inventor Yoshiaki Nagaura A report of the experimental results from Professor Masahiko Kurokawa is given below.

February 12, 2009 Anti-influenza virus activity test result report of catechin
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Kyushu Health and Welfare University
Prof. Masahiko Kurokawa 2nd Biochemistry Course

the purpose

The anti-influenza virus activity of catechin (Sanphenon BG-3, Polyphenon 70S) is examined using a mouse nasal infection model of influenza virus.

experimental method

  According to the experimental schedule of attached sheet 1, catechin administration (peritoneal administration, 50 mg / kg x 2 times / day for 5 days from 0 to 5 days of infection) mice (BALB / 0, rabbit, body weight 20-22 g, 6 The influenza virus was intranasally infected (PR8 strain grown on MDCK cells, 500 PFU / mouse) into the week-old), and changes in body weight and survival after infection were examined daily. Moreover, the combined use effect with Tamiflu (1 mg / kg, po injection, twice a day × 5 days) was also examined at the same time.

Experimental result

1. Examination of anti-influenza virus activity of catechin alone Catechin (BG-3, 70S) was administered intraperitoneally once before infection, and then catechin was administered twice a day.

Change in body weight (Fig. 4)
-From day 1 to day 8 after infection, weight loss due to infection was significantly suppressed from the early stage of infection by administration of 70S alone.
-By BG-3 single administration, the tendency for the weight loss by infection to be suppressed was observed in the late stage of infection (after 4th day).
-Between the first day and the eighth day after infection, the body weight loss due to infection was significantly suppressed by the administration of Tamiflu alone. However, the combined administration of the two catechins and Tamiflu did not significantly suppress weight loss due to infection.

Survival rate (survival days) (FIG. 5)
・ No significant increase in survival days was observed by administration of two catechins alone until the 14th day after infection, but it seemed that the survival days of the BG-3 single administration group were extended. .
-Death of mice could not be confirmed until 14 days after infection by single administration of Tamiflu or combination administration of two catechins and Tamiflu.

Consideration

  Catechin (70S) significantly suppressed weight loss due to infection, and catechin (BG-3) appeared to prolong survival. For this reason, it is considered that the two catechins used exhibit some anti-influenza virus activity. Therefore, it is considered that the effectiveness of catechin can be demonstrated by conducting experiments in consideration of the administration method, dosage, and in vivo absorption efficiency. On the other hand, regarding the combined effects with Tamiflu, there are many considerations including the determination of Tamiflu single dose, so it is considered desirable to examine the effectiveness of catechin alone.

Schedule (Dr. Nagaura) _20081217
Examination of antiviral effect of Nagaura sample using influenza infected mice

Sample: 2 types of samples
1. Sanphenon BG-3
2. Polyphenon 70S

Mouse: BALB / c, sputum, body weight 20-22g, 6 weeks old, purchased from Kudo

Dosing schedule;

Exam breakdown;

Check item (1) Weight change → FIG. 4
(2) Days of survival → FIG. 5

Sample adjustment
1. sample
50 mg / kg, i. p. injection
Held twice a day for 5 days at 9:00 and 19:00 in the morning
Dosing volume is 0.2ml at a time
2. Tamiful
1 mg / kg, i. p. injection
Held twice a day for 5 days at 9:00 and 19:00 in the morning
Dosing volume is 0.2ml at a time

Prof. Nagaura Joint Research: Examination of the effects of catechins on preventing influenza infection by animal experiments_2009

  Also shown in FIG. 6 is herpes simplex skin in which mice are infected by Prof. Kimiyasu Shiraki of the Department of Virology of Toyama University School of Medicine, Department of Virology, University of Toyama, Toyama City and Professor Yoshiaki Nagaura of the present inventor. It is evaluation of the experimental result regarding the effectiveness as a chemical | medical agent of a catechin with respect to the mouse | mouth infected with the herpesvirus of an infection model (henceforth abbreviated as herpesvirus). FIG. 6 shows the experimental results of intraperitoneal administration of 50 mg per kg (50 mg × 2 ip per kg) to mice infected with herpes virus twice a day with catechin. According to the results of this experiment, as shown in FIG. 6, since the progression of the disease state is suppressed at the early stage of infection with the herpes virus in the mouse, the therapeutic effect of the mouse infected with the catechin with the herpes virus is It was an experimental result that can be judged to be.

  Furthermore, the difference between the influenza virus described in FIG. 4 and FIG. 5 and the herpes virus, which is the causative virus for herpes simplex skin infection, also described in FIG. And the free influenza virus lyses in the blood by growing in the cells of the trachea, but the nature of herpesviruses is from the surface of cells infected with herpesvirus to the surface of another cell Since it is a virus, influenza virus and herpes virus are different viruses. FIG. 4, FIG. 5, and FIG. 6 show that catechin has an effect as a drug against both the influenza virus dissolved in the blood and the virus present on the surface of the cell. These are experimental results of mice infected with influenza virus and herpes virus.

  Furthermore, the human body acquires immunity in the order of (1) to (4) so that the human body memorizes immunity and the immune memory is established and the human body acquires immunity.

  (1) refers to antigens that have invaded the human body, such as viruses, bacteria, syphilis, protozoa, parasites, pollen, proteins, peptides formed with 5 or more amino acids, and macrophages It begins with phagocytic phagocytosis.

  As for (2), the phagocytic cell presents a part of the antigen to the helper T cell.

  As (3), the helper T cell further transmits information to the B cell, and causes the B cell to differentiate into a plasma cell having an antibody producing ability capable of producing an antibody.

  As for (4), plasma cells produce antibodies to form antigen-antibody complexes. In general, it takes about one week from the initial infection until the above immune response is established.

  In addition, when the same antibody described above is first infected in the human body and the antigen has invaded the human body for the second time, the immune memory is established. Plasma cells produce antibodies and form antigen-antibody complexes.

Furthermore, the plasma cells that have memorized immunity described above may forget their immune memory over time. This is the tolerance of immune memory.

  Further, as described above, when an antigen such as a malaria parasite or influenza virus that has entered the human body enters the human body, the human body acquires immune memory in approximately seven days. The human body acquires immune memory and plasma cells produce antibodies, forming an antigen-antibody complex, and the human body uses antigens such as malaria parasites or influenza viruses that have invaded the human body. Destroying or killing.

  As described in the above (1), as described above, in the case of the first infection in which an antigen such as a malaria parasite or influenza virus, which is an antigen in the human body, has entered the human body, it takes approximately 7 days. The human body acquires immune memory. This means that, for example, in the case of the first infection in which a human body has been invaded by an antigen such as a protozoan malaria or influenza virus, the human body has invaded the human body for approximately one week until it acquires immune memory. If the growth of antigens such as malaria parasites or influenza viruses is suppressed or killed by drugs, etc., the proliferation of malaria parasites or influenza viruses will be increased, and the human body's autoimmunity will increase the proliferation of malaria parasites or influenza viruses. The progression of the disease will stop.

  In conclusion (2), the human body acquires immune memory in about 7 days as explained above. Here, we asked Associate Prof. Akira Ishii of Hamamatsu Medical University shown in Table 3, the experimental results of infecting mice with malaria parasites, and the results of Kyushu Health and Welfare University shown in Fig. 4 and Fig. 5. According to the result of infecting mice with influenza virus, which was requested by Prof. Masahiko Kurokawa, first of all, as shown in Table 3, mice were invaded with the antigen malaria parasite or influenza virus. From the results, in the experimental results of invasion of malaria parasites, the mice survived for 18 days from the initial infection with each of the combined use of artesunate and catechin, or the combined use of chloroquine and catechin, so the mouse acquired immune memory. It would have survived until. Further, as shown in FIG. 4 and FIG. 5, the results of the experiment in which an influenza virus as an antigen was allowed to invade a mouse showed that both the catechins polyphenone 70S and sunphenon BG-3 were 8 days after the initial infection. It is an experimental result in which it can be determined that the mouse has acquired immune memory by comparing the weight increase / decrease of the mouse up to the eye with the control. Furthermore, as shown in FIG. 5, it is an experimental result in which it is possible to determine that the survival days have been extended by acquiring immune memory, particularly with respect to Sanphenon BG-3.

  Conclusion (3) is that the human body is allowed to survive for approximately 7 days after the invasion of antigens such as Plasmodium or influenza virus into the human body, until the human body acquires immune memory. By using a drug for the purpose, by suppressing or killing the growth of antigens such as malaria parasites or influenza viruses that have invaded the human body, the human body can survive by the immune memory acquired by the human body. It will be possible. In short, antibodies are produced in a period of about 7 days after the antigen enters the human body. If the human body is allowed to survive for a period of about 7 days, the human body can survive by autoimmunity.

  In addition, treatment of athlete's foot which develops mainly due to vesicular ringworm fungus, which can be formed on the toes of the human body, toes, toes, or toes by using electromagnetic waves. As a means, microwaves that are electromagnetic waves within a range that does not affect the human body, for example, improved home electronics described in Examples 1, 2, 3, 4, 5, 6, and 7 above. Using a magnetron oscillator that is a range, for example, a microwave of 500 W for about 20 seconds, a microwave is periodically applied at a rate of about once every 10 minutes, or a toe of a human body that is an affected part, or Sweat blisters that are bacteria, fungi, and sputum that cause athlete's foot to parasitize the stratum corneum inside the skin by irradiating the affected part such as the toes of the toes, the fingers of the hands, or the tips of the hands with microwaves Using an electromagnetic wave that is a microwave, for example, The stratum corneum is heated to a temperature of around 65 ° C. using a microwave, and the heating time is about 20 seconds. In order to selectively kill the athlete's foot without affecting the skin and stratum corneum of the human body by denaturing and degrading the lipid by extremely short-time microwave heating. It has been found that using can effectively kill and kill athlete's foot.

  In addition, the present invention is the largest infectious disease on earth, and 300 to 700 million people are infected per year, and more than 2 million people die per year. The name of the disease can be used to eradicate malaria by heating the mosquitoes that transmit the malaria parasite, the causative agent of the disease, in the air using electromagnetic waves and killing the mosquitoes.

  In addition, the present invention relates to an infection of Trypanosoma protozoa, which is a parasite mediated by flies, in which 400,000 people are infected each year in Central Africa and 60,000 people die. Develops in By using the electromagnetic wave to kill the sleeping sickness fly using electromagnetic waves in the range that does not affect the human body, cattle, and horses, use the cows in the vast undeveloped farmland in central Africa It can be used to be able to cultivate.

  Furthermore, the present invention relates to infectious diseases such as endometrial cancer, cervical cancer, vaginal chlamydia, resistant tuberculosis, and resistant syphilis caused by malaria, AIDS, hepatitis C, influenza, papillomavirus (HPV). As a means of treating patients who have developed symptoms after infection (hereinafter abbreviated as infectious disease), or catechin is administered orally, intravenously, intraperitoneally, intramuscularly, and intravenously to cancer cells. The therapeutic means such as administration can be used as a therapeutic means for infectious diseases such as malaria, AIDS, hepatitis C, influenza, papilloma virus, vaginal chlamydia, resistant tuberculosis, and resistant syphilis, or cancer cells.

  Further, in the present invention, in developing countries, for example, in sub-Saharan Africa, the cause of the spread of AIDS patients is that the number of AIDS patients is increasing due to sexual acts by prostitution by prostitutes. The first reason is why there are so many AIDS patients in Africa. Therefore, the number of prostitutes will increase. Naturally, AIDS patients also become an increasing chain of poverty. As a means to block this poverty chain, the contraceptives that serve as both the contraceptive effect of the present invention and the effect of the intravaginal disinfectant (Microbicide) are provided to prostitutes. By using a contraceptive that also has an effect, it also serves as an intravaginal fungicide (Microbicide) as a means to block the poor chain that the AIDS patients expand and increase through prostitutes The contraceptive of the present invention can be used.

Mr. Kumiko Shintama, who was enrolled in the master's program at Okayama University Pharmaceutical Information Science Course, and Yoshiaki Nagaura, the inventor, jointly worked on Polyphenon 70S, manufactured and sold by Mitsui Norin Co., Ltd. It is evaluation of the experimental result which conducted the experiment regarding the antimalarial activity used.

As above, Kumiko Shintama, who was enrolled in the master's program of Okayama University's Pharmaceutical Information Science Course, and Yoshiaki Nagaura, the inventor, jointly produced and sold Mitsui Norin Co., Ltd. It is evaluation of the experimental result which conducted the experiment regarding the antimalarial activity using the polyphenone 70S which is manufactured, and the sun phenon BG-3 which Taiyo Chemical Co., Ltd. manufactures and sells.

A mouse that is a coronavirus companion using an alkaline extract of rooibos tea extracted by alkali extraction of rooibos tea to Dr. Fumihiro Taguchi, Department 3 of National Institute for Infectious Diseases, 4-7-1, Musashimurayama City Gakuen, Tokyo Shows the experimental results of inactivating the infectious murine hepatitis virus.

, And [Fig.5] Prof. Masahiko Kurokawa of the second course of biochemistry, Kyushu University of Health and Welfare, 1714-1 Yoshinocho, Nobeoka City, Miyazaki Prefecture, and Yoshiaki Nagaura, the inventor of the present invention, It is evaluation of the experimental result which conducted the experiment regarding the anti-influenza virus activity using polyphenone 70S manufactured and sold by Norin Co., Ltd. and Sunphenon BG-3 manufactured and sold by Taiyo Kagaku Co., Ltd.

The name of the product that Taiyo Kagaku Co., Ltd. manufactures and sells is Sanphenon BG-3, in collaboration with Prof. Kimiyasu Shiraki of the Faculty of Medicine and Pharmacy at Toyama University School of Medicine and Professor Yoshiaki Nagaura. It is evaluation of the experimental result regarding the effectiveness as a chemical | medical agent with respect to the mouse | mouth infected with the herpes virus of the herpes simplex skin infection model in which a mouse | mouth is infected using the catechin.

Claims (11)

  Typical mosquitoes or tsutsue fly (hereinafter abbreviated as abbreviated as mosquitoes) that transmit malaria parasites, trypanosoma protozoa, various viruses, and bacteria that are pathogens such as malaria, sleepiness, dengue fever, Japanese encephalitis, and yellow fever. A method and an apparatus for killing mosquitoes by heating them in the air using electromagnetic waves.   The electromagnetic wave oscillated using a magnetron, an oscillation source, a surface wave vibration, a pulse wavelength, and a solid vibration (hereinafter abbreviated as a crystal resonator) as an oscillation source is emitted and irradiated in the air, and A method and an apparatus for killing and killing the spotted mosquito according to Item 1 by heating in air using electromagnetic waves.   Quartz crystal processed using the crystal resonator processing means described in US Pat. No. 6,952,074B2, which describes the processing means invented and discovered by Yoshiaki Nagaura of the present inventor. 3. A directional sine wave electromagnetic wave that is amplified by using a vibrator as an oscillation source and that uses a sinusoidal electromagnetic wave according to claim 1 and 2 in the air using the electromagnetic wave. A method and apparatus for killing by heating and killing.   The purpose is to kill the dead fly that clings to the surface of the body skin of the cow or horse body using the electromagnetic wave to kill the fly fly that mediates the Trypanosoma protozoa that causes the sleepiness disease using electromagnetic waves. A method and an apparatus for killing by killing the fly fly according to claim 1, 2, and 3 by heating in air using electromagnetic waves.   Using electromagnetic waves, mainly affecting the human body, for example, as a means of treating athlete's foot that develops due to vesicular tinea on the toes or fingertips of the human body, or the fingers or fingertips of the hand The bacteria and fungi that cause athlete's foot to infest the stratum corneum inside the skin by irradiating the fingertips of the human foot or the fingertips of the hands with electromagnetic waves using the output within the range that does not give , And using a microwave, which is an electromagnetic wave, of the spirococcus trichophyton, for example, heating to about 65 ° C. for about 20 seconds to denature the protein that forms the athlete's foot. A method and an apparatus for killing the athlete's foot according to claim 1, 2, 3, and 4 for killing them using electromagnetic waves.   Catechin in the blood of patients with malaria, sleepiness, AIDS, hepatitis C, adult leukemia, dengue fever, Japanese encephalitis, yellow fever, tuberculosis, cancer cells, and influenza (hereinafter abbreviated as infectious disease) Is administered intravenously, intraperitoneally, intramuscularly, intravenously, and orally (hereinafter abbreviated as intravenously or orally) for infection, tuberculosis, or cancer A method of therapeutic means comprising treating a cell.   When catechin is administered intravenously for the purpose of treating infection using catechin, catechin containing no caffeine is used inside the total catechin content or catechin having a total catechin content For the treatment of infectious diseases by intravenous administration using catechins containing caffeine with the ratio of caffeine to 0%, 6% or less, or 10% or less The method of the treatment means characterized by treating the infection of said 6.   When catechin is administered intravenously for the purpose of treating infection using catechin, the mixing ratio of epigallocatechin gallate (EGCg) is 90% or less, or 80% or less, or the total catechin content, or 6 for the purpose of treating infections, tuberculosis bacteria, or cancer cells by intravenous administration using catechins containing a total catechin content of 70% or less, or 60% or less. A method of therapeutic means comprising treating the infectious disease according to claim 7 and 7.   Infectious disease, tuberculosis bacteria, or cancer cells are treated by intravenous administration or oral administration in combination of catechin and quinine, catechin and chloroquine, or catechin and artesunate, such as sunphenon BG-3 or polyphenone 70S. The method of the treatment means characterized by treating the infectious disease of said 6, 7, and 8 aiming at that.   When catechin is administered orally for the purpose of treating infectious diseases using catechins, the total catechin content contains caffeine at a ratio of caffeine of 5% or more. The above-mentioned 6, 7 for the purpose of treating infection, tuberculosis or cancer cells by oral administration using catechin mixed with caffeine containing catechin content. A method of therapeutic means comprising treating the infectious disease according to claim 8, 8, and 9.   Catechin is intravenously administered in the blood for the purpose of killing cancer cells in the blood where cancer cells float in the blood and metastasize to various organs using catechin. Cancer cells can be killed by chemically covalently binding to cancer cells. The infectious disease according to claim 6, 7, 8, 9 and 10, which aims to prevent cancer cells from floating in the blood and metastasizing by using this phenomenon, using catechin. A method of therapeutic means characterized in that.