JP2006212161A - Biological information measuring system, biological information measuring apparatus and data processor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological information measuring system for accurately performing the examination of a sleep apnea syndrome (SAS) and oxygen concentration measurement during walking of a home oxygen therapy (HOT) patient while reducing the burdens of measuring work to be put on the patient as much as possible, and provide a biological information measuring apparatus and a data processor. <P>SOLUTION: The biological information measuring apparatus 2 calculates an instant oxygen saturation at each point measured on the basis of obtained photoelectric pulse wave signals, calculates the average value (1-second oxygen saturation) of the instant oxygen saturation calculated in a period of one second from the point of time, the average value (three-second oxygen saturation) of the one-second oxygen saturation calculated in the period from the point of time to three seconds before, and the average value (twelve-second oxygen saturation) of the three-second oxygen saturation calculated in the period from the point of time to twelve seconds before at every interval of 1 second from measurement start, and displays the twelve-second oxygen saturation at a display part 10. Also, the instant oxygen saturation is stored, and when requested from a PC 3, the data of the instant oxygen saturation are provided for the PC 3. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a biological information measuring system, a biological information measuring device, and a data processing device that measure biological information such as oxygen saturation of arterial blood and a pulse rate.

  In the examination for sleep apnea syndrome (SAS), a device called a pulse oximeter may be used (for example, refer to Patent Document 1 below). This pulse oximeter is attached to a predetermined living body part of a subject, outputs light toward the living body part, and determines the oxygen saturation (instantaneous value) based on the amount of light transmitted or reflected through the living body part. Every time a predetermined time (for example, 1 second) elapses, the oxygen saturation (instantaneous value) obtained in a period from the elapsed timing to a time point that goes back to the past for a certain time (for example, 3 seconds) The average value is derived based on.

  The pulse oximeter is configured to be able to communicate with, for example, a personal computer in which a predetermined program is incorporated. For example, the personal computer provides the derived oxygen saturation average value data from the pulse oximeter. Then, based on this average value, for example, an index (Oxygen Desaturation Index ODI) indicating the number of changes in oxygen saturation and the number of reductions in oxygen saturation per unit time is calculated by the program. Analyze.

  As described above, when analyzing the oxygen saturation of a subject, an average value is derived based on the oxygen saturation (instantaneous value) obtained in a period from a predetermined timing to a time point that goes back a certain time in the past. If the oxygen saturation (instantaneous value) is used to analyze the subject's oxygen saturation, the oxygen saturation (instantaneous value) includes factors unrelated to blood flow, such as body turnover In order to avoid analysis of the subject's oxygen saturation based on this ineffective oxygen saturation, there may be an ineffective oxygen saturation that includes errors due to movement of the This is in order to be able to analyze as accurately as possible. Assuming that the fixed time going back in the past to derive an average value is called an average time, it is considered that the above-mentioned 3 seconds is effective as the average time.

On the other hand, the pulse oximeter may be used to measure and indicate the oxygen concentration during walking of a home oxygen therapy (HOT) patient. In this case, there is a possibility that more irrelevant factors of blood flow (for example, movement of the subject's body) occur due to walking movement than in the SAS examination, and there is more ineffective oxygen saturation. For this reason, the average time is set longer than that in the case of a test for sleep apnea syndrome, and for example, 12 seconds is considered to be effective.
JP-A-1-153139

  Thus, when measuring the oxygen concentration during walking of HOT patients, the effective average time is different from that during the examination of SAS, so calculation is made with an average time suitable for indicating the oxygen concentration during walking of HOT patients. It is necessary to derive the average value of oxygen saturation.

  Therefore, even when measuring the oxygen concentration during walking of HOT patients, the average value of the oxygen saturation in the average time (for example, the above-mentioned 3 seconds) set for the examination of SAS is derived by a pulse oximeter. It is conceivable to derive the average value of the oxygen saturation in the average time (for example, the above-mentioned 12 seconds) set for HOT from the average value of the oxygen saturation provided from the pulse oximeter.

  However, since the HOT patient walks while checking the average value of the oxygen saturation indicated by the pulse oximeter, the oxygen saturation of the HOT patient during walking is measured when measuring the oxygen concentration during walking of the HOT patient. It is necessary to show the average value. Therefore, in the above-described method, since the average value of oxygen saturation calculated with the average time set for HOT is not derived by the pulse oximeter, the average value of oxygen saturation for HOT is calculated using the pulse. Cannot show to patient with oximeter.

  Separately from this method, the biological information measuring device is provided with a mode for deriving an average value of oxygen saturation with an average time of 3 seconds, for example, and a mode for deriving an average value of oxygen saturation with 12 seconds, and a pulse oximeter It is conceivable to adopt a configuration in which the measurer switches the mode according to the purpose of use.

  However, in this configuration, the setting switching work is imposed on the subject, and accordingly, there is a situation in which the subject gives a burden of measurement work and the subject performs measurement while forgetting to switch the setting. is assumed.

  The present invention has been made in view of the above circumstances, and is a biological information measurement system that can accurately perform both a SAS examination and an oxygen concentration measurement during walking of a HOT patient while reducing the burden of measurement work on a patient as much as possible. An object is to provide an information measuring device and a data processing device.

  According to the first aspect of the present invention, a biological information measuring device that acquires data relating to biological information and a data processing device that performs a predetermined process on the data acquired by the biological information measuring device via a predetermined communication path. A biological information measuring system configured to be communicable, wherein the biological information measuring device is configured to measure a predetermined biological information and a biological signal derived from the biological information measured by the measuring means, First computing means for computing first data relating to biological information; second computing means for computing second data different from the first data based on the first data; and the second Display means for displaying data; and communication means for transmitting the first data to the data processing apparatus, wherein the data processing apparatus receives the first data transmitted from the biological information measuring apparatus. The apparatus includes a communication unit and at least one of a display unit that displays the first data received by the communication unit and a storage unit that stores the first data. .

  The invention according to claim 5 is a biological information measuring device that provides the data to a data processing device that performs predetermined processing on the data upon receiving provision of data relating to biological information, Measuring means for measuring; first calculating means for calculating first data related to biological information based on a biological signal derived from biological information measured by the measuring means; and the first calculating means based on the first data. 2nd calculating means for calculating 2nd data different from 1 data, Display means for displaying the 2nd data, Communication means for transmitting the 1st data to the data processor It is characterized by.

  The invention according to claim 6 includes a communication unit that exchanges data with a biological information measurement device that acquires data related to biological information, and processes data received from the biological information measurement device by the communication unit. A data processing apparatus comprising: a display unit that displays first data received by the communication unit; and a storage unit that stores the first data received by the communication unit. It is characterized by.

  According to the present invention, in the biological information measuring device, predetermined biological information is measured by the measuring means, and based on the predetermined biological information, the first data relating to the biological information is calculated by the first calculating means, Second data different from the first data is calculated by the second calculation means based on the first data. Then, the second data is displayed by the display means, and the first data is transmitted to the data processing device by the communication means.

  In the data processing device, when the communication device receives the first data transmitted from the biological information measuring device, the first data is displayed when the data processing device includes a display device. Is displayed and the first data is stored when the data processing apparatus is provided with a storage means.

  Thereby, for example, when measuring the oxygen concentration during walking of a HOT patient, the biological information measuring device obtains HOT data (second data) and displays the data on the display means of the biological information measuring device. Thus, the data for the SAS examination (the first data) can be obtained at the time of the examination of the SAS.

  At that time, as in the invention described in claim 4, the first data is obtained from the instantaneous value or the instantaneous value derived in a period from the time point at which the instantaneous value is derived to the time point that is traced back to the past by the first time. The second data was derived in a period from the time when the instantaneous value was derived to a time point that was traced back to the past by a second time longer than the first time. When the average value calculated using the instantaneous value is used, accurate data can be generated and provided.

  According to a second aspect of the present invention, in the biological information measuring system according to the first aspect, the biological information measuring device further includes storage means for storing the first data.

  According to this invention, since the biological information measuring device is provided with the storage means for storing the first data, not only immediately after the calculation of the first data, but also at the desired timing to the data processing device. Data can be provided, and various data can be generated based on the first data.

  According to a third aspect of the present invention, in the biological information measurement system according to the first or second aspect, the data processing device is configured to use the second data and / or the data based on the first data received by the communication unit. Or a calculation means for calculating third data different from the second data, a display means for displaying the second data and / or the third data, the second data and / or the It is characterized by comprising at least one of storage means for storing the third data.

  According to this invention, in the data processing apparatus, the second data and / or the third data different from the second data is calculated based on the first data, and thus the biometric information is concerned. Multiple types of data can be obtained. Further, at least one of display means for displaying the second data and / or the third data and a storage means for storing the second data and / or the third data on the data processing device. Since one of them is provided, a plurality of types of data obtained as described above can be displayed and stored for a desired purpose.

  According to the first, fifth, and sixth aspects of the invention, it is possible to accurately perform, for example, a SAS test and an oxygen concentration measurement during walking of a HOT patient while reducing the burden of measurement work given to the patient as much as possible.

  According to the second aspect of the present invention, since the first data can be provided to the data processing device at a desired timing, the convenience of the biological information measuring device can be improved, and the first data Since various data can be generated based on the above, it is possible to expand the field of use of the biological information measurement system.

  According to the third aspect of the invention, various data can be obtained, and the field of use of the biological information measurement system can be expanded.

  According to the invention described in claim 4, since accurate data can be generated and provided, a highly accurate inspection or the like can be performed.

  An embodiment of a biological information measurement system according to the present invention will be described. FIG. 1 is a block diagram illustrating a configuration of a biological information measurement system according to the first embodiment.

  As shown in FIG. 1, the biological information measuring system 1 includes a biological information measuring device 2 and a personal computer (hereinafter referred to as PC) 3. The PC 3 corresponds to the data processing device in the claims.

  The biological information measuring device 2 is a portable device including a box-shaped device main body 4 and a measuring unit 6 electrically connected to the device main body 4 by a cable 5. For convenience of explanation, the configuration of the measurement unit 6 will be described.

  The measuring unit 6 has a pair of light emitting unit 7 and light receiving unit 8 arranged to face each other with a predetermined relative positional relationship, and the light emitting unit 7 and the light receiving unit 8 are fixed in the relative positional relationship at each one end. In this state, they are connected by the connecting member 9. The light emitting unit 7 is a light source including, for example, a light emitting diode (LED) that emits red light R having a wavelength λ1 in the red region and an LED that emits infrared light IR having a wavelength λ2 in the infrared region. The measurement unit 6 is an example of a measurement unit in the claims.

  The light receiving unit 8 includes a photoelectric conversion element such as a silicon photodiode (Silicon Photo Diode) that generates a current having a magnitude corresponding to the intensity of the received light. In the present embodiment, the light receiving unit 8 includes at least a wavelength. It has sensitivity to light of λ1 and light of wavelength λ2. The light receiving unit 8 receives light having wavelengths λ1 and λ2 from the light emitting unit 7 that has passed through the living tissue LB. If the LEDs are arranged close to each other on the same substrate, the two types of light paths that pass through the living body can be made substantially the same path, and the conditions for each light can be made almost the same. .

  In the measurement unit 6 of the present embodiment, the fingertip of the subject during sleep is examined during sleep apnea syndrome (SAS), and the fingertip of the patient during walking during measurement of oxygen concentration during walking of a home oxygen therapy (HOT) patient. In the state where the light emitting unit 7 and the light receiving unit 8 are sandwiched, the light emitting unit 7 alternately emits the red light R having the wavelength λ1 and the infrared light IR having the wavelength λ2, and the light receiving unit 8 causes the light emitting unit to emit light. The light receiving operation is performed in synchronization with the light emitting operation 7. The light emitting operation of the light emitting unit 7 and the light receiving operation of the light receiving unit 8 are controlled by a control unit 18 to be described later, and the light projecting / receiving operation for each light is, for example, 1/40 to 1/30 (second). Performed in any period between. When receiving the light, the light receiving unit 8 outputs a current signal having a magnitude corresponding to the intensity of the received light to the I / V conversion unit 16 in the apparatus main body 4 to be described later.

  The apparatus main body 4 includes a display unit 10 and an input operation unit 11 installed below the display unit 10. For example, power is supplied from a power supply source such as a battery or a dry cell mounted in a loading chamber (not shown). To drive.

  The display unit 10 includes, for example, an LCD (Liquid Crystal Display), a 7-segment LED (Light Emitting Diode), an organic photoluminescence display device, a CRT (Cathode-Ray Tube), or a display device such as plasma. 18 (see FIG. 2), which will be described later, will be displayed. The display unit 10 corresponds to a display unit of the biological information measuring device in the claims.

  The input operation unit 11 includes a power button for turning on / off the power of the apparatus body 4, a start button for inputting an instruction to start measuring oxygen saturation, a stop button for inputting an instruction to end the measurement, and the like. Have.

  The PC 3 includes a display unit 12, an input operation unit 13, and an apparatus main body 14. The display unit 12 includes a CRT (Cathode-Ray Tube), an LCD (Liquid Crystal Display), a PDP (Plasma Display Panel), a rear projector, or the like, and displays data sent from the biological information measuring device 2 and various information. Is what you do. The input operation unit 13 is used to input an instruction or various information for causing a control unit 27 (see FIG. 8) described later to perform a desired process / operation, and corresponds to, for example, a keyboard or a mouse. The apparatus main body 14 is equipped with a communication unit 25 and a control unit 27 (see FIG. 8), and an external storage unit 26 (see FIG. 8) composed of, for example, a hard disk for storing various programs and data. Yes.

  In the biological information measuring system 1 of this embodiment, data such as oxygen saturation described later acquired by the biological information measuring device 2 is sent to the PC 3 via the cable 5 and the insulating unit 15, and the received oxygen is received by the PC 3. Saturation data or data derived based on the data is displayed on the display unit 12. The insulating unit 15 is composed of a photocoupler, for example, and converts an electrical signal into an optical signal.

  FIG. 2 is a block diagram showing an electrical configuration of the biological information measuring device 2. As shown in FIG. 2, the biological information measuring apparatus 2 includes a measurement unit 6, a display unit 10, an input operation unit 11, a current / voltage conversion unit (hereinafter referred to as I / V conversion unit) 16, an analog / digital conversion unit (hereinafter referred to as “digital / digital conversion unit”). (A / D conversion unit) 17, control unit 18, and communication unit 19.

  The measurement unit 6, the display unit 10, and the input operation unit 11 correspond to the measurement unit 6, the display unit 10, and the input operation unit 11 illustrated in FIG.

  The I / V conversion unit 16 converts the current signal output from the light receiving unit 8 into a voltage signal at a period of 1/40 (second), for example, and converts this voltage signal to the A / D conversion unit 17 as a photoelectric pulse wave signal. Output. The A / D conversion unit 17 converts the analog photoelectric pulse wave signal output from the I / V conversion unit 16 into a digital photoelectric pulse wave signal, and outputs the digital photoelectric pulse wave signal to the control unit 18. It is.

  The control unit 18 includes a microprocessor, a DSP (Digital Signal Processor), and the like, and in accordance with data and programs stored in the storage unit 20 described later, oxygen in the arterial blood is input from the input photoelectric pulse wave signal. This is to calculate the degree of saturation. The control unit 18 includes a measurement control unit 21, a bandpass filter unit (hereinafter abbreviated as “BPF unit”) 22, a stored oxygen saturation calculation unit 23, and a display oxygen saturation calculation unit 24.

  The measurement control unit 21 controls the operations of the light emitting unit 7 and the light receiving unit 8 of the measurement unit 6, and in this embodiment, the red light R with the wavelength λ1 and the infrared light IR with the wavelength λ2 are respectively 1/1 /, for example. Light is emitted from the light emitting unit 7 alternately at a cycle of 40 (seconds).

  The BPF unit 22 is composed of a digital filter, and filters the photoelectric pulse wave signal A / D converted by the A / D conversion unit 17. The BPF unit 22 may be composed of a digital low-pass filter and a digital high-pass filter, or may be composed of an FIR (Finite Impulse Response) filter.

  Based on the photoelectric pulse wave signal filtered by the BPF unit 22, the stored oxygen saturation calculation unit 23 calculates the oxygen saturation at each measured time point (hereinafter, this oxygen saturation is referred to as instantaneous oxygen saturation). .

  Here, the principle of deriving blood oxygen saturation using light by the memory oxygen saturation calculator 23 will be described.

Oxygen is transported to each cell of the living body by hemoglobin (Hb) in the blood, and hemoglobin combines with oxygen in the lung to become oxygenated hemoglobin (HbO ₂ ), and returns to hemoglobin when oxygen is consumed in the cells of the living body. . The oxygen saturation level SpO ₂ is the ratio of oxygenated hemoglobin in the blood. When the hemoglobin concentration is expressed as CHb and the oxygenated hemoglobin concentration is expressed as CHbO ₂ , the oxygen saturation SpO ₂ is expressed by the following equation (1).

On the other hand, the absorbance of hemoglobin and the absorbance of oxyhemoglobin have wavelength dependence, and each extinction coefficient α (λ) has an extinction characteristic as shown in FIG. In FIG. 3, the horizontal axis represents the wavelength of light, the unit is nm, the vertical axis is the extinction coefficient, and the unit is 10 ⁻⁹ cm ² / mole.

  As shown in FIG. 3, hemoglobin and oxygenated hemoglobin have different light absorption characteristics. Hemoglobin absorbs more light than oxyhemoglobin for red light R having a wavelength λ1 in the red region, but absorbs less light than oxyhemoglobin for infrared light IR exceeding the wavelength λ2 in the infrared region. . That is, for example, when the wavelength of the infrared light R is 660 nm where the difference in absorption coefficient between oxygenated hemoglobin and hemoglobin is the largest, and the wavelength of the infrared light IR is 815 nm where the absorption coefficients of oxygenated hemoglobin and hemoglobin are equal, oxygenated hemoglobin and hemoglobin The amount of transmitted light of the infrared light IR does not change even if the ratio to the above changes. On the other hand, the amount of transmitted red light R is small when the amount of hemoglobin is large, and is large when the amount of oxygenated hemoglobin is large. That is, the oxygen saturation can be obtained by taking the ratio of the amount of transmitted light.

  The biological information measuring device 2 obtains the blood oxygen saturation by using the difference in the light absorption characteristics of such hemoglobin and oxyhemoglobin with respect to the red light R and the infrared light IR. Note that the pulse rate can also be obtained by utilizing the difference in absorption characteristics of hemoglobin and oxygenated hemoglobin with respect to red light R and infrared light IR.

  When a living body is irradiated with light, part of the light is absorbed and the rest is transmitted. The living body is composed of an arterial blood layer, a venous blood layer, and a tissue other than the arterial blood layer and the venous blood layer. As shown in FIG. 4A, the light absorption in the living body includes absorption by a tissue other than the arterial blood layer and the venous blood layer, absorption by the venous blood layer, and absorption by the arterial blood layer. Since tissues other than the arterial blood layer and the venous blood layer and the venous blood layer do not change with time, the absorption of light in this portion is substantially constant.

  On the other hand, since the diameter of the arterial blood layer changes due to the heartbeat and the diameter of the blood vessel changes, the absorption of light by the arterial blood layer varies with time due to the pulse as shown in FIG. That is, the change in the transmitted light intensity is based on only information on arterial blood, and it is considered that the influence of tissues other than the arterial blood layer and venous blood layer and the venous blood layer is hardly included. In FIG. 4B, the horizontal axis represents time, and the vertical axis represents transmitted light intensity.

  When comparing the light quantity changes of the red light R and the infrared light IR, it is necessary to cancel the difference in the incident light quantity. FIG. 5 is a diagram schematically showing the relationship between incident light and transmitted light incident on a living body.

  As shown in FIG. 5 (a), it is substantially difficult to make the incident light quantity I0 to the living body the same between the red light R and the infrared light IR. Since the rate differs between red light R and infrared light IR, it is not possible to compare only the amount of change in transmitted light intensity due to the arterial blood layer.

  Here, the transmitted light amount when the artery is the thinnest (when the transmitted light amount is the largest) is I, and the transmitted light amount when the artery is the thickest (when the transmitted light amount is the smallest) is (I−ΔI). . As shown in FIG. 5 (b), it is considered that when the arterial blood having a thickness ΔD is irradiated with light having a light amount I, transmitted light having a transmitted light amount (I−ΔI) is obtained.

Then, as shown in FIG. 6, by a quantity of transmitted light I _R and transmitted light amount I _IR of the infrared light IR of the red light R is normalized to match (I _{IR '=} I _R), the amount of light by the arterial blood The change ratio (ΔI _R / I _R ) / (ΔI _IR / I _IR ) is calculated, and the oxygen saturation is calculated.

  The relationship between the incident light and the reflected light can be expressed by the following formula 2 according to Lambert Beer's law.

  E represents the extinction coefficient of the light-absorbing material, and C represents the concentration of the light-absorbing material.

  By substituting each wavelength of the red light R and the infrared light IR into the formula 2 and taking the ratio of each side, the following formula 3 can be obtained.

Note that I _R represents the transmitted light amount of the red light R, I _IR represents the transmitted light amount of the infrared light IR, E _R represents the extinction coefficient of the red light R, and E _IR represents the extinction coefficient of the infrared light IR.

FIG. 7 is a graph showing the relationship between the extinction coefficient ratio (E _R / E _IR ) and the oxygen saturation SpO ₂ when the wavelengths of red light R and infrared light IR are 660 nm and 815 nm, respectively. It is. As shown in FIG. 7, the oxygen saturation SpO ₂ increases in proportion to the decrease in the extinction coefficient ratio (E _R / E _IR ).

  As described above, when the stored oxygen saturation calculation unit 23 calculates the instantaneous oxygen saturation, the data of the instantaneous oxygen saturation is stored in the storage unit 20 and the biological information measuring device 2 is connected to be communicable with the PC 3. When there is a request from the PC 3, the communication unit 19 is caused to perform processing for transmitting the data to the PC 3.

  In addition, every time 1 second has elapsed from the start of measurement, the stored oxygen saturation calculation unit 23 calculates blood oxygen saturation out of the instantaneous oxygen saturation calculated in the period from each elapsed timing measurement time point to a time point traced back by 1 second. Invalid data removal process that excludes invalid oxygen saturation data that is out of the appropriate range due to factors unrelated to the flow, such as body movements (data of oxygen saturation that is thought to reduce the accuracy of analysis) from the target After that, the average value of the instantaneous oxygen saturation that is effective is calculated. Hereinafter, this average value is referred to as 1 second oxygen saturation.

  Further, the stored oxygen saturation calculation unit 23 calculates the average value of the 1-second oxygen saturation calculated in the period from each elapsed timing measurement time point to the time point traced back by 3 seconds every time one second has elapsed from the start of measurement. Is calculated. Hereinafter, this average value is referred to as 3-second oxygen saturation. The stored oxygen saturation calculation unit 23 corresponds to the first calculation means in the claims, and the instantaneous oxygen saturation and 1 second oxygen saturation derived by the stored oxygen saturation calculation unit 23. And 3 second oxygen saturation is an example of the 1st data in a claim.

  The display oxygen saturation calculation unit 24 calculates the average value of the 3-second oxygen saturation calculated in the period from each elapsed timing measurement time point to the time point traced back for 12 seconds every time one second has elapsed from the start of measurement. To do. Hereinafter, this average value is referred to as 12-second oxygen saturation. When the display oxygen saturation calculation unit 24 calculates the 12-second oxygen saturation, the display oxygen saturation is displayed on the display unit 10. This 12-second oxygen saturation data is data to be provided to the home oxygen therapy (HOT) patient when measuring the oxygen concentration during walking.

  Thus, the reason why the instantaneous oxygen saturation data is stored in the storage unit 20 and the 12-second oxygen saturation data is displayed on the display unit 10 is as follows.

  That is, when the biological information measuring device 2 is used for measuring / instructing oxygen concentration during walking of a HOT patient, the biological information measuring device 2 needs to be carried by the patient and show oxygen saturation data to the walking patient. When used for examination of SAS, the subject is sleeping, and oxygen saturation data is generally confirmed by PC3 after waking up.

  Therefore, when used for measuring / instructing oxygen concentration during walking of a HOT patient, it is necessary to display data on the biological information measuring device 2, whereas when used for SAS examination, biological information is not necessarily displayed. There is no need to display data on the measuring device 2, as long as the data can be confirmed by the PC 3.

  In view of such a method of using the biological information measuring device 2 according to the purpose, in the present embodiment, the biological information measuring device 2 uses the oxygen saturation (for oxygen concentration measurement / instruction during walking of the HOT patient) ( In this embodiment, 12 second oxygen saturation) is displayed, and even when the biological information measuring device 2 is used for SAS inspection, the oxygen saturation for SAS inspection (3 second oxygen saturation) in the PC 3 Is stored in the biological information measuring device 2, and when requested by the PC 3, the data on the instantaneous oxygen saturation is provided.

  Thereby, when the biological information measuring device 2 is used for measuring / instructing oxygen concentration during walking of the HOT patient, the walking patient should check the data of oxygen saturation for 12 seconds in real time. In addition, when used for the examination of SAS, the subject can check the data of oxygen saturation for 3 seconds with PC3 after getting up. The display oxygen saturation calculation unit 24 corresponds to the second calculation means in the claims, and the 12-second oxygen saturation derived by the stored oxygen saturation calculation unit 23 is calculated as follows. It is an example of the 2nd data in a range.

  The storage unit 20 is composed of an EEPROM (Electrically Erasable and Programmable Read Only Memory), an SRAM (Static Random Access Memory), an FeRAM (Ferroelectric Random Access Memory), etc., and the instantaneous oxygen saturation calculated by the storage oxygen saturation calculation unit 23 The degree is memorized. In addition, the storage unit 20 includes, for example, an identification number of the biological information measuring device 2 and an auto power-off function that automatically turns off the power in a predetermined time (for example, 8 hours) from when the power is turned on. Data such as a predetermined time (auto power off time), the number of times each measurement data is downloaded to the PC 3, such as whether the light emission amount of the light emitting unit 7 is out of the allowable range or the amplitude of the pulse wave is out of the allowable range Data indicating the state is also stored.

  The communication unit 19 includes an interface such as RS-232C, USB, and IrDA, and performs data communication with the PC 3 via the cable 5 and the insulating unit 15. The communication unit 19 corresponds to a communication unit of the biological information measuring device in the claims.

  FIG. 8 is a block diagram showing an electrical configuration of the PC 3. As illustrated in FIG. 8, the PC 3 includes a display unit 12, an input operation unit 13, a communication unit 25, an external storage unit 26, and a control unit 27. The input operation unit 13 and the display unit 12 correspond to the input operation unit 13 and the display unit 12 illustrated in FIG.

  The communication unit 25 is configured by an interface such as RS-232C, USB, or IrDA, and performs data communication with the biological information measuring device 2 via the cable 5 and the insulating unit 15. The communication unit 25 corresponds to the communication means of the data processing device in the claims.

  The external storage unit 26 includes a hard disk, USB memory, CD (Compact Disc), DVD (Digital Versatile Disc), floppy disk (registered trademark), and the like, and stores data received by the communication unit 25. The external storage unit 26 corresponds to a storage unit of the data processing device in the claims.

  The control unit 27 is composed of a microcomputer and controls the driving of each member in the PC 3 described above in association with each other. The control unit 27 functionally includes a storage processing unit 28, a mode determination unit 29, a calculation unit 30, and a display control unit 31.

  The storage processing unit 28 stores the instantaneous oxygen saturation data received from the biological information measuring device 2 via the communication unit 25 in the external storage unit 26.

  The mode determination unit 29 determines a display mode designated by the input operation unit 13 among a plurality of display modes described later. In the present embodiment, the first display mode in which the instantaneous oxygen saturation data stored in the external storage unit 26 is displayed as a graph on the display unit 12 as it is and the second display mode in which the 12-second oxygen saturation is displayed are displayed. Have.

  Further, in the present embodiment, when calculating the average value of oxygen saturation, it has a function of specifying a period (average time) from the measurement time point to the time point going back in the past, and when this average time is specified Also, a third display mode for displaying the average value of oxygen saturation calculated during the period is also provided. The mode determination unit 29 determines the display mode designated by the input operation unit 13 from the first to third modes.

  When the second display mode or the third display mode is designated by the input operation unit 13, the arithmetic unit 30 stores the average value of oxygen saturation corresponding to the mode in the external storage unit 26. It is calculated from the instantaneous oxygen saturation.

  For example, when the second display mode is designated, the calculation unit 30, as with the display oxygen saturation calculation unit 24 of the biological information measurement device 2, each time when one second has elapsed from the start of measurement. The average value of the 3-second oxygen saturation calculated in the period from the timing to the time point traced back for 12 seconds is calculated.

  Further, when the third display mode is selected and the average time t is designated, the calculation unit 30 has passed one second from the start of measurement based on the instantaneous oxygen saturation stored in the external storage unit 26. At the time point, the average value of the 1-second oxygen saturation or the average value of the 3-second oxygen saturation calculated in the period from each elapsed timing to the time point traced back by t seconds is calculated. That is, when the average time t is t = 3 · m (m is a natural number), the arithmetic unit 30 calculates the 3-second oxygen saturation calculated in the period from the time point to the time point that goes back by t seconds. When the average time t is t ≠ 3 · m (m is a natural number), the 1-second oxygen saturation calculated in the period from the time point to the time point that goes back to the past by t seconds The average value of is calculated. Hereinafter, this average value is referred to as t-second oxygen saturation. Note that the t-second oxygen saturation may be calculated from the instantaneous oxygen saturation or the 1-second oxygen saturation regardless of the average time t.

  When the average time t is specified as t = 3, since the 3-second oxygen saturation is calculated, the oxygen saturation data for the SAS inspection is obtained. The computing unit 30 corresponds to the computing means of the data processing device in the claims.

  In accordance with the display mode specified by the input operation unit 13, the display control unit 31 stores the instantaneous oxygen saturation stored in the external storage unit 26 or the 12-second oxygen saturation or the t-second oxygen calculated by the calculation unit 30. The degree of saturation is displayed in a graph. That is, when the first display mode is designated by the input operation unit 13, the display control unit 31 performs a process of displaying the instantaneous oxygen saturation stored in the external storage unit 26 as a graph as it is, and the second When the third display mode is designated, processing for displaying the 12-second oxygen saturation or the t-second oxygen saturation calculated by the calculation unit 30 in a graph is performed.

  Hereinafter, operations and processing in the biological information measuring apparatus 2 and the PC 3 will be described. FIG. 9 is a flowchart showing a measurement operation performed by the biological information measuring device 2, FIG. 10 is a flowchart showing a communication process performed between the biological information measuring device 2 and the PC 3, and FIG. It is a flowchart which shows the process performed by.

  As shown in FIG. 9, in the biological information measuring device 2, when a power button (not shown) is turned on, the control unit 18 executes the program stored in the storage unit 20, and the measurement unit 6, I / V Each unit such as the conversion unit 16, the A / D conversion unit 17, and the storage unit 20 is initialized (step # 1), and waits for a measurement start instruction (NO in step # 2).

  When there is a measurement start instruction (YES in step # 2), the control unit 18 starts measuring time with a timer (not shown) (step # 3). Then, the control unit 18 causes the measurement unit 6 to perform a light projecting / receiving operation (step # 4), and the I / V conversion unit 16 and the A / D conversion unit 17 perform the above-described operations on the data from the measurement unit 6. After performing the processing (step # 5), the control unit 18 performs filtering to calculate the instantaneous oxygen saturation (step # 6). The control unit 18 stores the calculated instantaneous oxygen saturation data in the storage unit 20 (step # 7).

  Next, the control unit 18 determines whether or not 1 second has been timed by the timer (step # 8), and when 1 second has not been timed by the timer (NO in step # 8), step # 8. 4 to # 8 are repeated, and when 1 second is counted by the timer (YES in step # 8), the average value (1 second) of instantaneous oxygen saturation obtained from the present time to 1 second before (Oxygen saturation) is calculated (step # 9). At this time, any data that deviates from the preset range for the instantaneous oxygen saturation is considered to have deviated from the range due to factors unrelated to blood flow, so the data on the instantaneous oxygen saturation is invalid. And not to be included in the average calculation target.

  Next, the calculated average value of 1 second oxygen saturation and the average value of 1 second oxygen saturation (3 seconds oxygen saturation) calculated between the current time and 3 seconds before are calculated (step #). 10) Further, an average value (12-second oxygen saturation) of the 3-second oxygen saturation calculated from the present time to 12 seconds before is calculated (step # 11). Note that the process of step # 10 is not executed for 3 seconds from the start of measurement, and the process of step # 11 is not executed for 12 seconds from the start of measurement because there is no average calculation target or lacks.

  The control unit 18 displays the 12-second oxygen saturation data calculated in this way on the display unit 10 and stores it in the storage unit 20 (step # 12). Control unit 18 then executes the processes of steps # 4 to # 13 until an instruction to end measurement is received (NO in step # 13). When there is an instruction to end measurement (YES in step # 13), a series of steps are performed. Terminate the process.

  When the biological information measuring device 2 and the PC 3 are connected by the cable 5, the process shown in FIG. 10 can be executed. As shown in FIG. 10, in the biological information measuring apparatus 2, when the power is turned on while being connected to the PC 3 by the cable 5 (YES in step # 21), the control unit 18 includes the communication unit 19 and the like. An initialization process is performed (step # 22), a communication mode communicable with the PC 3 is set (step # 23), and a signal for instructing transmission of oxygen saturation data (hereinafter referred to as a transmission instruction signal). ) Is sent from the PC 3 (NO in step # 24).

  On the other hand, when the PC 3 is turned on (YES in step # 28), the control unit 27 displays an initial screen on the display unit 12 (step # 29), and the data from the biological information measuring device 2 is displayed. Wait until input for instructing download is made (NO in step # 30).

  When an input for instructing download is made (YES in step # 30), the control unit 27 performs processing for transmitting the transmission instruction signal to the biological information measuring device 2 (step # 31), and the biological information measuring device. Wait until oxygen saturation data is received from 2 (NO in step # 32).

  When biological information measuring apparatus 2 receives the transmission instruction signal from PC 3 (YES in step # 24), control unit 18 reads data from storage unit 20 (step # 25). Here, the data read from the storage unit 20 is data on the instantaneous oxygen saturation. Then, the control unit 18 performs a process of transmitting the instantaneous oxygen saturation data to the PC 3 (step # 26). Thereafter, control unit 18 repeatedly executes the processes of steps # 24 to # 27 until the power of biological information measuring device 2 is turned off (NO in step # 27), and when the power is turned off (step #). 27), the series of processing is terminated.

  When the PC 3 receives the instantaneous oxygen saturation data from the biological information measuring device 2 (YES in step # 32), the control unit 27 stores the instantaneous oxygen saturation data in the external storage unit 26 (step # 33). ). Then, control unit 27 determines whether or not an instruction to end the activation of the program has been input (step # 34), and if an instruction to end the activation of the program has been input (YES in step # 34). If an instruction to end the series of processes and end the start of the program has not been input (NO in step # 34), it is determined whether or not an input for instructing data display has been performed ( Step # 35).

  As a result, if an input for instructing data display has not been made (NO in step # 35), control unit 27 returns to the processing in step # 30 while instructing data display. When an input is made (YES in step # 35), a process for deriving and displaying data to be displayed on display unit 12 based on the data stored in external storage unit 26 is executed (step # 36).

  As shown in FIG. 11, when the control unit 27 determines that the first display mode is designated (YES in step # 41), the instantaneous oxygen saturation data stored in the external storage unit 26 is directly displayed as a graph. A display process is performed (step # 42).

  If control unit 27 determines that the second display mode has been designated (NO in step # 41, YES in # 43), 12s oxygen saturation based on the instantaneous oxygen saturation stored in external storage unit 26 The degree is calculated, and the 12-second oxygen saturation data is displayed (step # 44). In calculating the 12-second oxygen saturation, as in the case of the biological information measuring apparatus 2, data on the instantaneous oxygen saturation that is not effective and deviated from the appropriate range due to factors unrelated to blood flow, for example, body movement, etc. The invalid data removal process is performed to exclude the data of oxygen saturation that is considered to decrease the value from the target.

  Further, when determining that the third display mode is designated (NO in step # 43), control unit 27 determines a period (time) from the measurement time point to the past time point when calculating the average value of oxygen saturation. When t) is designated by the input operation unit 13, the average value of the t-second oxygen saturation calculated during that period is calculated and displayed (step # 45).

  For example, when the time t = 6 is input by the input operation unit 13, after performing the invalid data removal process, when 1 second has elapsed from the measurement start time, the time from the elapsed time to 1 second before The average value of instantaneous oxygen saturation (1 second oxygen saturation) obtained in the meantime is calculated, and at the time when 1 second has elapsed from the measurement start time, it is calculated between that time and 3 seconds before. The average value of 1 second oxygen saturation (3 second oxygen saturation) was calculated, and further, 3 seconds calculated between the elapsed time and 6 seconds before when 1 second elapsed from the measurement start time. An average value of oxygen saturation is calculated, and the average value is displayed on the display unit 12.

  An example of a graph displayed on the display unit 12 by the process of step # 42 is shown in FIG. 12A, an example of a graph displayed on the display unit 12 by the process of step # 44 is shown in FIG. An example of a graph displayed on the display unit 12 by the process 45 is shown in FIG.

  As described above, since the biological information measuring device 2 calculates the 12-second oxygen saturation and displays it on the display unit 10, when measuring the oxygen concentration during walking of the HOT patient, the patient is subjected to the 12-second oxygen saturation. Degree can be shown. In addition, since the instantaneous oxygen saturation data derived in the biological information measuring device 2 is provided to the PC 3, when the biological information measuring device 2 is used for a SAS test, the oxygen saturation suitable for the test is used. Degree (3 second oxygen saturation) can be derived. As a result, even if the biological information measuring device 2 is used in any of the above cases, it is possible to provide oxygen saturation data suitable for the method of use, and to provide instructions for SAS examinations and walking HOT patients. Can be done accurately.

  Further, when the third display mode is designated in the PC 3, when the average time of oxygen saturation is calculated, a period (time t) from the measurement time point to the retroactive time point is designated by the input operation unit 13. In addition, since the t-second oxygen saturation is calculated and displayed based on the instantaneous oxygen saturation data provided from the biological information measuring device 2, various analyzes can be performed. The application field of the measurement system 1 can be expanded.

  Further, since the data on the instantaneous oxygen saturation derived in the device 2 is stored in the biological information measuring device 2, the data can be provided to the PC 3 at an arbitrary timing, and the biological information can be provided. The measuring device 2 not only provides 12-second oxygen saturation data to the patient, but also generates various data from the instantaneous oxygen saturation data and provides the data to the biological information measuring device 2 or the PC 3. It becomes possible.

  In addition to or in place of the above-described embodiment, modifications described in the following [1] to [9] may be employed.

  [1] In the above embodiment, the 3 second oxygen saturation is derived for the SAS test, and the 12 second oxygen saturation is derived for the instruction to the walking HOT person. The average times “3 seconds” and “12 seconds” suitable for the above are merely examples, and other values may be used.

  [2] In the above embodiment, when calculating the 3-second oxygen saturation, the average calculation target is the 1-second oxygen saturation calculated in the past 3 seconds. May be instantaneous oxygen saturation.

  In the embodiment, when calculating the 12-second oxygen saturation, the average calculation target is the 3-second oxygen saturation calculated in the past 12 seconds. However, the present invention is not limited to this, and is calculated in the past 12 seconds. It is also possible to calculate the 12-second oxygen saturation without calculating the 1-second oxygen saturation and the 3-second oxygen saturation, or to calculate the 1-second oxygen saturation calculated in the past 12 seconds. The 12-second oxygen saturation may be calculated without calculating the 3-second oxygen saturation.

Furthermore, in the said embodiment, calculation timings, such as 1 second oxygen saturation and 3 second oxygen saturation,
Although it is assumed that 1 second has elapsed from the measurement start time, the present invention is not limited to this, and can be changed as appropriate.

  [4] In the above embodiment, the biological information measuring device 2 stores only the instantaneous oxygen saturation in the storage unit 20, but is not limited to this, and the instantaneous oxygen saturation, 1 second oxygen saturation, and 3 At least one of the second oxygen saturations may be stored in the storage unit 20. If the 1-second oxygen saturation and the 3-second oxygen saturation are stored in the storage unit 20 of the biological information measuring device 2, the calculation of the 1-second oxygen saturation and the 3-second oxygen saturation in the PC 3 becomes unnecessary.

  [5] The biological information measuring apparatus 2 may display the pulse rate together with the calculated 12-second oxygen saturation data.

  [6] As in the above-described embodiment, the light emitting unit 7 and the light receiving unit 8 are not limited to be disposed substantially opposite to each other through the living body, and the light emitting unit 7 and the light receiving unit 8 are disposed in the same direction with respect to the living tissue. And you may make it the light-receiving part 8 receive the reflected light from a biological body. Also in this case, if a light emitting diode (LED) that emits red light R having a wavelength λ1 in the red region and an LED that emits infrared light IR having a wavelength λ2 in the infrared region are arranged close to each other on the same substrate, The two types of light paths that pass through the living body can be made substantially the same path, and the conditions for each light can be made substantially the same.

  In addition, the living body part is not limited to the above-described finger, and may be an earlobe, for example, in consideration of ease of measurement of living body information such as the ease of wearing of the living body part and the SN ratio of measurement data. If the person is an infant, it may be the hand, the back of the foot, or the wrist.

  [7] In the above embodiment, the PC 3 is taken as an example of the data processing apparatus.

  [8] In the communication process between the biological information measuring device 2 and the PC 3, the data transmitted from the biological information measuring device 2 to the PC 3 in response to the transmission instruction signal from the PC 3 is not limited to the data related to the oxygen saturation. Data such as the file number of the oxygen saturation data, the measurement start time, the data amount, the pulse rate, the content of the warning generated at the time of measurement, the pulse wave waveform data, and the remaining battery level may be transmitted together.

  In addition, when the biological information measuring device 2 is equipped with an acceleration sensor that detects the movement of the subject's body or an angular velocity sensor that includes a gyro that uses a piezoelectric element, the acceleration and angular velocity information is also oxygen saturated. It may be transmitted to the PC 3 together with the data related to the degree.

  Further, the PC 3 is equipped with a function for designating the type of data stored in the biological information measuring device 2, for example, storing only oxygen saturation data or storing oxygen saturation data and pulse wave data. If the biological information measuring apparatus 2 is equipped with a function for setting a storage mode according to the type of data stored in accordance with an instruction from the PC 3, information indicating the storage mode is also stored in the oxygen saturation level. The data may be transmitted to the PC 3 together with the data.

  [9] The biological information measuring device may display not only the oxygen saturation but also information such as the pulse rate, the body position, and the pulse wave on the display unit 10. In addition, when the biometric information measuring device stores data of oxygen saturation for 3 seconds and sends this data to the PC 3, the oxygen saturation per unit time is reduced from the data of oxygen saturation for 3 seconds. It is also possible to calculate an index (Oxygen Desaturation Index ODI) representing the number of times and display the calculation result on the display unit 10. The biological information may be not only information related to blood flow but also brain waves and cardiac radio waves, and the detection medium is not limited to light but may be electricity or the like.

It is a block diagram which shows the structure of 1st Embodiment of the biological information measurement system which concerns on this invention. It is a block diagram which shows the electrical structure of a biological information measuring device. It is a graph which shows the light absorption characteristic of hemoglobin and oxyhemoglobin. It is a figure which shows absorption of the light by a biological body. It is a figure which represents typically the relationship between the incident light which injects into a biological body, and transmitted light. It is a figure for demonstrating normalization of the transmitted light amount by infrared light. It is a figure which shows the relationship between ratio of an absorption coefficient, and oxygen saturation. It is a block diagram which shows the electric constitution of a personal computer. It is a flowchart showing a measurement operation performed by the biological information measuring device, It is a flowchart which shows the communication process performed between a biometric information measuring device and PC. It is a flowchart which shows the process performed by a personal computer. It is a figure which shows an example of the graph displayed on the display part of a personal computer.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Biological information measuring system 2 Biological information measuring device 3 Personal computer 6 Measuring part 7 Light emission part 8 Light receiving part 10 Display part 12 Display part 18 Control part 19 Communication part 21 Storage part 23 Memory oxygen saturation calculation part 24 Display oxygen saturation calculation Unit 25 communication unit 26 external storage unit 27 control unit 30 calculation unit 31 display control unit

Claims (6)

Biological information configured such that a biological information measuring device that acquires data related to biological information and a data processing device that performs predetermined processing on the data acquired by the biological information measuring device can communicate via a predetermined communication path A measuring system,
The biological information measuring device includes:
Measuring means for measuring predetermined biological information;
First computing means for computing first data related to biological information based on biological signals derived from biological information measured by the measuring means;
Second computing means for computing second data different from the first data based on the first data;
Display means for displaying the second data;
Communication means for transmitting the first data to the data processing device,
The data processing device includes:
A communication means for receiving the first data transmitted from the biological information measuring device;
A biological information measurement system comprising at least one of display means for displaying the first data received by the communication means and storage means for storing the first data.   The biological information measuring system according to claim 1, wherein the biological information measuring device further includes a storage unit that stores the first data. The data processing device includes a calculation unit that calculates the second data and / or third data different from the second data based on the first data received by the communication unit,
It is characterized by comprising at least one of display means for displaying the second data and / or the third data and storage means for storing the second data and / or the third data. The biological information measuring system according to claim 1 or 2. The first data is an instantaneous value or an average value calculated using the instantaneous value derived in a period from a point in time of derivation of the instantaneous value to a point in time going back to the past by a first time,
The second data is an average value calculated using the instantaneous value derived in a period from a point in time at which the instantaneous value is derived to a point in time that goes back in the past by a second time longer than the first time. The living body information measuring system according to claim 1, wherein the living body information measuring system is a living body information measuring system. A biological information measuring device that provides the data to a data processing device that performs predetermined processing on the data upon receiving provision of data relating to biological information;
Measuring means for measuring predetermined biological information;
First computing means for computing first data related to biological information based on biological signals derived from biological information measured by the measuring means;
Second computing means for computing second data different from the first data based on the first data;
Display means for displaying the second data;
A biological information measuring apparatus comprising: communication means for transmitting the first data to the data processing apparatus. A data processing apparatus comprising a communication unit that exchanges data with a biological information measurement device that acquires data related to biological information, and that processes data received from the biological information measurement device by the communication unit,
A data processing apparatus comprising at least one of display means for displaying first data received by the communication means and storage means for storing first data received by the communication means.

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