JP2006158974A - Integral type physiologic signal evaluation apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To make it possible to obtain parameters of all heart blood vessels, by obtaining ECG and PPG signal simultaneously, as well as the oxygen concentration in blood. <P>SOLUTION: The integral type physiologic signal evaluation apparatus of the present invention includes a sensing interface module, an analog signal processing module, an analog to digital conversion unit, a digital signal processing module, a display unit, and a power module. This sensing interface module includes two sensing electrodes to get ECG signal of the subject and at least one optical probe set, which is combined selectively with one of these sensing electrodes, in order to obtain PPG signal of the subject at the same time when obtaining this ECG signal. This digital signal processing module executes algorithms separately for at least one ECG parameter, and the ECG signal and the PPG signal of the digital format in order to obtain at least one blood vessel parameter. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a physiological signal evaluation apparatus, and more particularly to an integrated physiological signal evaluation apparatus for simultaneously measuring an electrocardiogram signal (ECG signal) and a photoelectric pulse wave (PPG (photoplethysmographic)) signal. The device utilizes a sensing interface that cooperates with subsequent signal analysis and processing to conveniently obtain a number of useful physiological parameters such as ECG signals, blood pressure pulses, pulse oxygen saturation, and the like.

  In recent years, people have enjoyed more delicate and tasty foods but lacked adequate exercise habits, so the factors of cardiovascular disease have increased in recent years. In addition, advances in biotechnology and medicine have extended lifespan, but cardiovascular function weakens with age. In recent years, related cardiovascular diseases have become a major health threat.

  In terms of medical equipment, heart diagnosis is mainly based on the use of electrocardiograms. An electrocardiogram records the process of myocardial electrical transmission when the myocardium contracts rhythmically, and the result can be expressed as an electrocardiogram, which allows doctors to determine whether the heart function is normal. Judgment can be made. On the other hand, oximeters can estimate the function of blood circulation and the state of oxygen supply in the blood, and are also an important indicator of the amount of oxygen sent to brain tissue and metabolized, pulse oxygen saturation It is the most commonly used equipment for evaluating the degree (SPO2). In addition, two indicators derived from the analysis of blood pressure pulses to estimate the degree of vascular aging and the elastic function of the blood vessels, namely the large arterial stiffness index (SI) and the vascular reflex index (RI). ) By adapting the blood pressure pulse with an ECG signal, the pulse wave velocity (PWV) can be obtained to further understand the relationship between blood vessels and blood flow.

  Clinically, physicians typically use an electrocardiogram that uses at least three electrodes to record multiple lead measurements to obtain more detailed ECG signaling data. However, from the ECG signal measurement principle, one vector ECG signal can be obtained by using two electrodes.

  With regard to the blood pressure pulse, referring to FIG. 1, when the relationship between the pulse and the blood vessel is illustrated by taking a finger as an example, the pulse waveform of the finger can be divided into two parts. The first part results from the pulse propagating directly to the finger along the aorta, while the second part results from the pulse propagating to the lower body and reflecting along the aorta and the subclavian artery . The time delay between the first peak and the second peak is mainly determined by the conduction time of the pulse propagating back and forth along the subclavian artery. The conduction time is directly proportional to the height of the subject and correlates with vascular elasticity. The greater the elasticity of the blood vessel, the higher the ability of the blood vessel to absorb the pulse, so the conduction time of the reflected pulse becomes longer and the pulse wave velocity becomes slower. Therefore, the elastic state of the blood vessel can be known from the blood pressure pulse.

There are two main methods for detecting pulse waveforms today. One is by the pressure method and the other is by optical means. The pressure method is similar to blood pressure measurement, that is, as disclosed in Patent Documents 1 to 3 granted to Chorin Medical Technology, the test portion of the subject is covered with a cuff, and the air is After pumping into the cuff, the pulse variation is detected by a pressure sensor. The company's product VP-1000 / 2000 also uses the pressure method to measure the ratio of ankle blood pressure to upper arm blood pressure and pulse wave velocity.
US Pat. No. 6,802,814 US Pat. No. 6,758,819 US Pat. No. 6,758,820

Optical methods mainly use light properties such as reflection, absorption, conduction, and the like. For example, taking infrared rays as an example, blood combined with oxygen has more infrared absorption than blood from which oxygen has been released. When the heart is in systole, the blood absorbs more infrared light because the amount of oxygen in the artery that contains faster moving oxygen increases. The situation is reversed when the heart is in diastole. This type of optical method that uses light to illuminate the subject's body and receives and records optical signals from blood vessels with time and tissue variations is called the photoelectric pulse wave (PPG) method. The PPG method is not only related to the oxygen concentration in the blood, but also responds to pulse variations and is used to calculate SI, RI, PWV and SPO2. For example, Patent Literature 4 discloses using an optical probe to obtain PPG.
US Patent Application No. 2004/0015091 Publication

  There are PPG-related facilities on the market that detect blood pressure pulse waveforms to calculate relevant parameters for vascular function. For example, Micro Medical in the United States uses an optical probe to detect a blood pressure pulse and further provides an SI value, a “Pulse Trace PCA (PT2000)” device, an electrocardiogram of the subject, a blood pressure pulse, and a PWV. In order to calculate, the "Pulse Trace PWV (PT400)" apparatus that uses three electrodes and a Doppler probe simultaneously was announced.

  The above mentioned parameters, such as SI, RI, PWV and SPO2, are very useful in inferring a subject's cardiovascular pathology and are often used for clinical diagnosis. Nevertheless, based on different measurement principles, conventional instruments must use different sensor elements to obtain ECG signals, pulse oxygen saturation and blood pressure pulses separately, so cardiovascular indicators and parameters If it is necessary to obtain all of the above, a plurality of different measuring instruments must be used, which is time consuming and inconvenient.

  In order to solve the problems existing in the prior art of obtaining cardiovascular parameters efficiently and easily, the present invention integrates optical measurement principles and electrical measurement principles into ECG signals and PPGs. Combine sensing electrodes with an optical probe to allow simultaneous acquisition of signals and further obtain oxygen concentration in the blood and obtain all cardiovascular parameters through an algorithm that processes and analyzes the signals Design an integrated measuring instrument with a detection interface.

SUMMARY OF THE INVENTION An object of the present invention is to have an integrated sensing interface for optical and electrical measurements to simultaneously acquire ECG and PPG signals to obtain an electrocardiogram, blood pressure pulse waveform and oxygen saturation. It is to provide a body type physiological signal evaluation apparatus.

  Another object of the present invention is to provide a design that can evaluate parameters for cardiovascular function by analyzing and calculating ECG and PPG signals.

  Another object of the present invention provides a sensing interface that integrates ECG signal sensing technology and optical sensing principles to obtain multiple physiological guidewires such as ECG signal, pressure pulse waveform and pulse oxygen saturation. It is to be.

  Another object of the present invention is to provide an apparatus with a sensing interface for measuring and analyzing cardiovascular parameters. In addition to obtaining ECG signals, the device can simultaneously record blood pressure pulses and pulse oxygen saturation, and through calculations and analysis, heart rate, ST segment, QRS interval, pulse oxygen saturation, stiffness index, reflection Obtain cardiovascular parameters such as index, pulse wave velocity, etc.

  To achieve this goal, the present invention utilizes a bi-electrode ECG signal measurement technique to design a sensing interface for simultaneous acquisition of ECG and PPG signals in combination with optical physiological signal measurement. It serves as a basis for calculating and analyzing cardiovascular parameters, thereby simplifying conventional equipment or equipment and making it easier for users to monitor their own cardiovascular conditions.

  Other objects, advantages and novel features of the invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings.

Detailed Description of Preferred Embodiments An integrated physiological signal evaluation device, constructed in accordance with the present invention, primarily utilizes electrical and optical signal sensing principles to provide ECG signals, blood pressure pulses and pulses. Design a sensing interface that combines different sensing elements to obtain the oxygen saturation index.

  Regarding the optical signal detection principle of pressure pulses, the Beer-Lambert law must be mentioned. The law states that when light of a certain wavelength is absorbed by a substance dissolved in a solvent, the amount of transmitted light (I) is an exponential function of the product of the concentration of the dissolved substance and the transmission distance in the solvent. The formula is as follows.

（１）

(1)

  In the above formula, ε is an extinction coefficient.

  Similarly, when light passes through a subject's tissue, skin, muscle, bone and blood absorb a certain amount of light. The amount of light absorbed by the skin, muscles and bones is constant but varies with the oxygen concentration in the blood. Because of the effects of the circulatory system, that is, oxygen-free blood is air-exchanged in the lungs into oxygen-containing blood that is transported throughout the body, the PPG method records fluctuations in oxygen concentration in the blood be able to. Furthermore, since the oxygen concentration in the blood varies with the blood pressure pulse, the blood pressure pulse waveform can be estimated from the variation in the oxygen concentration.

  As shown in FIG. 2, taking as an example the blood pressure pulse waveform of the PPG of the subject's finger, the time delay between the first peak and the second peak is the subject along the subclavian artery. Depending on the propagation time of the pulses that propagate to the lower body of the person and reflect back through the subclavian artery. Assuming that the pulse propagation distance is directly proportional to the height of the subject and that the pulse propagation time from the aorta to the thick artery correlates with the elasticity of the blood vessel, the stiffness index of the thick artery can be estimated by the following equation.

（２）

(2)

In the above formula,
SI is the vascular stiffness index,
ΔT _DVP is the delay time between two peaks in one pulse waveform,
DVP is a digital volume pulse.

  Furthermore, the difference between the heights of the two peaks is used to estimate the intensity of the reflection propagating back through the artery calculated as:

（３）

(3)

In the above formula,
a is the height of the second peak,
b is the height of the first peak.

  The SI and RI values in equations (2) and (3), respectively, are obtained from the blood pressure pulse waveform. However, ECG signals need to cooperate when it is desired to obtain PWV. Since PWV is used to estimate the speed of the pulses generated by the heart and transmitted through the blood vessels and propagated to the limbs, the faster the PWV, the harder the blood vessels. Therefore, PWV is significantly correlated with SI. Referring to FIG. 3, if the blood vessel is hardened like a pottery, the pulse rate is increased because the pulse is not easily absorbed by the blood vessel. On the other hand, if the blood vessel has elasticity like rubber, the pulse becomes slow. Research reports point out that PWV is highly correlated with cardiovascular disease, and that a high pWV value leads to a high probability that the subject has coronary artery disease.

  Referring to FIG. 4, the calculation of PWV is as follows.

（４）

(4)

In the above formula,
D is the pulse propagation distance,
PTT is the pulse propagation time.

  As shown in FIG. 4, in order to calculate the PWV, it is necessary to combine with the ECG signal to know where the transport of blood from the heart begins. In the ECG signal, the “R” wave is easily detected, and therefore, the R wave signal is generally used as a mark of the starting point in time.

  Using a single wavelength of light makes it possible to obtain a PPG for knowing blood pressure pulse fluctuations, but two to obtain pulse oxygen saturation (SPO2), an important parameter of cardiovascular function. In order to obtain the peak, it is necessary to use a light source having at least two different wavelengths. When a person breathes, the subject's extracorporeal oxygen enters the bronchus, from where it is transported to the alveoli and exchanged into the blood, and then transported throughout the body for delivery to the tissue. SPO2 is mainly used to estimate the concentration of hemoglobin bound to oxygen. Since the blood in the body consists of two types, blood combined with oxygen and blood desorbed from oxygen, the concentration of hemoglobin combined with oxygen and the concentration of hemoglobin desorbed from oxygen are measured separately. It is necessary to use two types of light sources with different wavelengths and then evaluate the percentage of hemoglobin bound to oxygen as follows:

（５）

(5)

In the above formula,
HbO ₂ is the concentration of hemoglobin bound to oxygen,
Hb is the concentration of hemoglobin from which oxygen has been released.

  Equation (1) must be used to calculate the concentration of hemoglobin bound to oxygen and hemoglobin desorbed from oxygen. For expedient calculations, there is a variable OD defined herein, and equation (1) can be rewritten as follows:

（６）

(6)

  In particular, since red light and infrared light of about 660 nm and 940 nm, respectively, are commonly used to calculate SPO2, equation (6) can be written as:

（７）

(7)

  Therefore,

（８）

(8)

  In the above formula

  Equations (2) through (8) are for calculating SI, RI, PWV and SPO2, respectively, and when using the prior art, these different parameters have sensing elements of various designs. Must be measured by different devices. The integrated physiological signal evaluation apparatus of the present invention integrates the double electrode detection principle of an ECG signal with an optical detection probe to acquire an ECG signal, a blood pressure pulse, and SPO2, thereby simplifying a medical device, Applicable at home.

  FIG. 5 is a block diagram of the integrated physiological signal evaluation apparatus of the present invention. The apparatus includes a sensing interface module 10, an analog signal processing module 20, an analog to digital conversion unit 30, a digital signal processing module 40, and a display unit 50. The sensing interface module 10 includes two sensing electrodes 12, 12 ′ and an optical probe set 16. The sensing electrodes 12, 12 'are used to measure the ECG signal, and the optical probe set 16 combined with at least one of the sensing electrodes 12, 12' is used to measure the PPG signal. The detailed design of the sensing interface module 10 is described below.

  The analog signal processing module 20 is electrically connected to the sensing interface module 10 and is used to process ECG and PPG signals measured from the subject in analog form and amplify and filter these signals. . The analog-to-digital conversion unit 30 is used to convert the analog ECG signal and the PPG signal processed by the analog signal processing module 20 into digital signals. These digital signals can then be applied to various types of algorithms to obtain ECG parameters such as heart rate, ST segment, QRS interval, etc. and vessel parameters such as SI, RI, PWV, SPO2, etc. Processed by the digital signal processing module 40 to be executed. Such parameter information may be transferred for display on a display unit 50 such as a liquid crystal display, LED, or the like. In addition, the device may have a power system, such as a battery set or an external power source such as a household plug, to supply power to all the electrical components described above.

  In the present invention, the sensing interface module 10 is a very inventive design for simultaneously acquiring two different types of signals, an ECG signal and a PPG signal. Since there are two optical methods for detecting the PPG signal, the reflection method and the transmission method, the structure of the sensing interface module 10 is implemented differently. Furthermore, since the ECG signal can be recorded with at least two electrodes, and the blood pressure pulse and SPO2 can be recorded with at least one optical probe, the apparatus can be configured to detect electrodes 12, 12 It may include either one optical probe disposed on one of 'or two or more optical probes disposed on both sensing electrodes 12, 12'. In the following embodiment, there is only one optical probe set 16 disposed on one of the sensing electrodes 12, 12 '.

  As shown in FIG. 6A, in the optical reflection method, the detection interface module 10 includes two detection electrodes 12, 12 ′ and one optical probe set 16 disposed on one of the detection electrodes. Including. Each of the sensing electrodes 12, 12 ′ is in contact with the subject's body surface and records current fluctuations to acquire an ECG signal when the subject's myocardium contracts rhythmically. Have The optical probe set 16 includes at least one light emitter 160 and at least one light receiver 162. The light emitter 160 is used to emit light to the body surface of the subject, and the light receiver 162 is used to receive reflected light from the tissue on the body surface and create a PPG signal.

  In this method, the detection interface module 10 may be designed in a planar shape so as to be fixed and adhered to the body surface of the subject or to be easily contacted by the subject. Referring to FIG. 6B, taking the subject's finger as an example, when the finger 18 is placed on the detection electrode 12, 12 ′ (the detection electrode 12 ′ is not shown in FIG. 6B), the detection electrode 12, 12 'can receive and record the ECG signal sent from the heart. For ECG measurement with 12 leads, the signal from the fingers of both hands belongs to the ECG signal of the first lead. Both the light emitter 160 and the light receiver 162 are combined with one of the sensing electrodes 12, 12 'so that if it is necessary to know the blood pressure pulse, the light emitter 160 can be a light beam, eg, red light or In order to emit infrared light to a finger and obtain a PPG signal based on fluctuations in oxygen concentration in blood, it is necessary to receive the reflected light and record the amount of reflected light. SI and RI can be calculated by the following modules for processing these resulting PPG signals. Furthermore, PWV can also be calculated by measuring ECG and PPG signals simultaneously and combining them together. In order to estimate the oxygen concentration in the blood, the emitter 160 must emit two types of light sources with different wavelengths, typically red light and infrared light, and the receiver 162 In a clock-switching manner, two types of reflected light sources with different wavelengths, each corresponding to oxygen bound blood and oxygen desorbed blood, are received and the following modules are SPO2 Provide enough information to calculate

  Referring to FIG. 7A, which is another embodiment showing a cross-sectional schematic view of a transmissive sensing interface module 10, sensing interface module 10 is responsive and opposed, such as a ring, finger sheath, and the like. A fixture 90 having two inner surfaces is included. At least one of the detection electrodes 12, 12 ′ is enclosed inside and attached to one of the inner surfaces of the fixture 90 so that the contact surface 14 faces the body surface of the subject. The light emitter 160 and the light receiver 162 are also wrapped in the fixture 90 and are disposed on the inner surfaces on the opposite sides. In this embodiment, the optical probe set 16 and the sensing electrode 12 are wrapped in the same fixture 90. The light receiver 162 is disposed on the detection electrode 12 on the lower inner surface of the fixture 90, and the light emitter 160 is attached to the opposite inner surface of the fixture 90. Of course, the light emitter 160 and the light receiver 162 are interchangeable. After the light emitted from the light emitter 160 is sent to the subject and transmitted through the subject's tissue, the light receiver 162 can receive the transmitted light. When using this type of measurement method, the subject places the finger of one hand on the contact surface 14 of the detection electrode 12 ′ (not shown in FIG. 7B) and fixes the contact surface 14 of the detection electrode 12 to touch. Place the finger of the other hand in the tool 90. In this way, the ECG signal of the subject can be acquired by the sensing electrodes 12, 12 ', and as described above, the PPG signal can be either single wavelength light or two wavelength light in a time division manner. And provide to the following modules to calculate RI, SI, PWV and SPO2.

  Referring to FIG. 8, which is a more detailed block diagram of the present invention, when the subject uses the present invention, the sensing electrodes 12, 12 ′ of the sensing interface module 10 can acquire the subject's ECG signal, and the optical The target probe set 16 can simultaneously acquire the PPG signal of the subject. Thereafter, an analog signal processing module 20 electrically connected to the sensing interface 10 handles the ECG signal and the PPG signal separately. The analog signal processing module 20 includes an ECG signal processing module 22 that amplifies and filters the ECG signal, a photoelectric signal conversion unit 24 that converts the optical signal of the PPG into an electrical signal, and amplifies and filters the converted PPG signal. And a photoelectric signal processing unit 26. Thereafter, the ECG signal and the PPG signal are electrically transferred to an analog-to-digital conversion unit and converted into a digital signal. These ECG and PPG digital signals are then transferred to the digital signal processing module 40 for processing to calculate various physiological parameters. The digital signal processing module 40 is for further processing the ECG and PPG signals to obtain ECG parameters such as heart rate, ST segment and QRS interval, and PPG parameters such as SI, RI, PWV and SPO2. CPU42 is included. The detailed algorithm steps are shown in FIG. 9, and FIGS. 1-4 are referenced for a clear understanding.

  When the digital ECG signal is transferred to the CPU 42, the ECG signal processing procedure inputs the first step (S10), that is, the step of detecting the QRS wave from the ECG signal. Usually, the ECG signal is composed of a P wave, a QRS wave, and a T wave. However, QRS waves are caused by a depolarizing current before ventricular systole and are strong and easily detected. Furthermore, since the R wave is the basis of the heart rhythm, the first step is to detect the position of the QRS wave. Then, ECG parameters such as heart rate, ST segment, QRS section, etc. are calculated in step (S12) by calculating the voltage across the ECG signal and detecting the QRS signal.

  For a single light source PPG signal, when the PPG signal is transferred to the CPU 42, the PPG signal processing procedure inputs the following steps. The first step is a step of detecting the arrival position of the pulse. At present, there is no uniform criterion for determining the reaching position, but in general, the inflection point to ascend (indicated by # 1, # 2 and # 3 in FIG. 4, respectively) or the slope is the most The point of sudden rise or the peak of the pulse is adopted as the arrival position of the pulse. In this embodiment, the point at which the slope rises most rapidly is adopted as the arrival position of the pulse. The next step is a step of comparing the digital PPG signal with the QRS wave of the ECG signal and evaluating the pulse propagation time (PTT) from the QRS wave peak to the arrival position of the pulse (S22). The next step is a step (S24) in which the height of the subject and the examination site of the subject are estimated, and PWV is obtained using equation (4). In addition, the step (S30) of detecting the first and second peaks of the PPG signal and calculating the amplitudes of the first and second peaks and the time interval between these two peaks is also included in step (S20). Continue. The next step (S32) is a step of obtaining SI and RI by calculating equations (2) and (3). PWV, SI and RI can be obtained from a single light source PPG signal. Further, when there are two different light sources, for example, a red light source and an infrared light source, the CPU 40 continues to step (S30), followed by another step (S40) for determining the light absorption amount and the reflected light amount for the different light sources. ), I.e., detecting peaks and wave troughs of different types of PPG signals. Then, the next step is a step of obtaining SPO2 by calculating equations (5) to (8).

  After the CPU 42 calculates ECG parameters and blood vessel parameters, these parameters are transferred to a display unit 50, such as an LCD, LED, etc., to show visual information for the subject. The digital signal processing module 40 includes a storage unit 44 that is electrically connected to the CPU 42 and stores digital ECG signals, digital PPG signals, ECG parameters, and blood vessel parameters. Further, the CPU 42 of the digital signal processing module 40 is connected to the data transfer module 70 such as a USB interface, a Bluetooth interface, an infrared interface, a modem, etc., and receives data including signals and parameters stored in the storage unit 44. Transfer to an external digital information device 72 such as a personal computer, PDA, mobile phone, database, etc. to provide subsequent diagnosis and analysis and data management.

  The integrated physiological signal evaluation apparatus further includes an actuation unit 80 that is electrically connected to the CPU 42 to allow the subject to control the operation of the digital signal processing module. The operation unit 80 includes buttons, knobs, touch panels, etc. for performing desired operations such as measurement functions, addition / deletion / transfer of data in the storage unit 44, input of personal information of the subject, date setting, etc. May be provided in either way. With the power supply module 60 providing power to the entire measuring device, all modules and units can operate to succeed in achieving the effect of detecting and analyzing multiple different types of signals.

  Although numerous features and advantages of the invention and details of the structure and function of the invention have been listed in the foregoing description, the disclosure is illustrative only. Changes in detail, particularly in matters relating to shape, size and arrangement of parts, are those of the principles of the present invention that are best described by the meaning of the most common terms recited in the claims. You can go within the range.

The schematic diagram which shows the correlation between a blood-pressure pulse waveform and pulse propagation time. The schematic diagram of a blood pressure pulse waveform. The schematic diagram which shows the correlation with a blood-pressure pulse waveform and vascular sclerosis | hardenability. The schematic diagram which shows the correlation with a blood-pressure pulse waveform and an ECG signal. 1 is a block diagram of an apparatus of the present invention. The schematic diagram of the detection electrode structure of this invention. The schematic diagram of the measurement by the detection electrode of this invention. The schematic diagram of another embodiment of a detection electrode structure. FIG. 3 is a more detailed block diagram of the present invention. 3 is a flow chart of a parameter algorithm operating in the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Detection interface module 12, 12 'Detection electrode 14 Contact surface 16 Optical probe set 18 Finger 20 Analog signal processing module 22 ECG signal processing module 24 Photoelectric signal conversion unit 26 Photoelectric signal processing unit 30 Analog to digital conversion unit 40 Digital Signal processing module 42 CPU
44 Storage Unit 50 Display Unit 70 Data Transfer Module 72 External Digital Information Equipment 80 Actuation Unit 90 Fixing Device 160 Light Emitter 162 Light Receiver

Claims (9)

An integrated physiological signal evaluation device comprising a sensing interface module, an analog signal processing module, an analog to digital conversion unit, a digital signal processing module, a display unit, and a power supply module,
The detection interface module includes two detection electrodes for obtaining an ECG signal of the subject, and one of the detection electrodes for simultaneously obtaining the PPG signal of the subject when obtaining the ECG signal. At least one optical probe set, optionally combined, wherein the analog signal processing module is configured to analogly process the ECG signal and the PPG signal detected by the sensing interface module. The analog to digital conversion unit is electrically connected to the analog signal processing module for converting analog ECG and PPG signals into digital WCG and PPG signals. The digital signal processing module Electrically with the analog to digital conversion unit to perform an algorithm separately on the ECG and PPG signals in digital form to obtain at least one ECG parameter and at least one vascular parameter Integrated physiology, wherein the display unit is electrically connected to the digital signal processing module to display the ECG parameters and vascular parameters, and the power module provides power to all the above components Signal evaluation device.   The integrated physiological signal evaluation apparatus according to claim 1, wherein each of the detection electrodes has a contact surface for contacting the body surface of the subject to obtain the ECG signal.   The optical probe set includes at least one light emitter for emitting light to the subject and at least one light receiver for receiving light transmitted from the subject. An integrated physiological signal evaluation apparatus according to claim 1.   The integrated physiological signal evaluation apparatus according to claim 3, wherein the light emitted from the light emitter is red light or infrared light. The integrated physiological signal evaluation apparatus according to claim 1, 2, 3, or 4, comprising an ECG signal processing unit, a photoelectric signal conversion unit, and a photoelectric signal processing unit.
The ECG signal processing unit amplifies and filters the ECG signal detected from the subject, and the photoelectric signal conversion unit converts the optical PPG signal detected from the subject into an electrical PPG signal. And the photoelectric signal processing unit amplifies and filters the electrical PPG signal. The integrated physiological signal evaluation device according to claim 1, 2, 3 or 4, comprising a storage unit and a data transfer module,
The storage unit is electrically connected to the CPU for storing the digital format ECG signal, the digital format PPG signal, the ECG parameter, and a blood vessel parameter, and the data transfer module is the storage unit. An integrated physiological signal evaluation apparatus connected to the CPU for transferring signals and parameters stored in the external CPU to an external digital information device. A sensing interface module for an integrated physiological signal evaluation device comprising:
In order to obtain the ECG signal of the subject, two detection electrodes each having one contact surface that contacts the body surface of the subject, and the PPG signal of the subject simultaneously when obtaining the ECG signal A sensing interface module comprising at least one optical probe set combined with one of said sensing electrodes to obtain   The optical probe set includes at least one light emitter that emits light to the subject and at least one light receiver that receives light transmitted from the subject. Detection interface module as described in. The detection interface module according to claim 7 or 8, wherein the light emitted from the light emitter is red light or infrared light.

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