TWI270364B - Integrated biosignal measuring apparatus - Google Patents

Abstract

This invention is an integrated apparatus, which uses both electrical signal detection and optical sensing technology to acquire biosignals, that contains a module interface designed to measure both electrocardiographic signals and photoplethysmographic ones. Multiple algorithms are processed at the same time to calculate electrocardiographic parameters including, but not limiting to, heart rate, ST segment and QRS. In additions, advanced parameters including, but not limiting to, blood vessel stiffness index (SI), blood vessel reflection index (RI), pulse wave velocity (PWV), blood oxygen saturation (SpO2) can also be calculated. This design simplifies the traditional methods/equipments to measure blood vessel function. This design also provides a simplified method to understand the physiological conditions of the heart and blood vessels. The apparatus has important application in the diagnosis and prevention of cardiovascular related diseases.

Description

1270364 IX. Description of the Invention: [Technical Field] The present invention relates to a physiological signal measuring device design, and more particularly to an integrated physiological signal measuring device capable of simultaneously measuring an ECG signal and a light plethysmogram signal The design uses the measurement interface combined with optical sensing and electrical signal sensing, and with signal analysis and processing, various physiological parameters such as ECG, vascular pulse wave and blood oxygen concentration can be easily obtained. [Previous technique] According to modern people, due to the exquisite diet and lack of exercise habits, the risk factors of heart and vascular diseases increase, and with the advancement of medical technology, the average life expectancy is prolonged year by year. The function of blood vessels is gradually reduced, and various factors have made heart and blood vessel related diseases have become a major threat to the health of Chinese people in recent years. From the medical point of view, 'the current phase of the diagnosis of heart and blood vessel function, the heart is mainly based on the heart shed instrument, the electrocardiograph can record the heart in the process of producing rhythmic electrical materials, and the heart is now In clinical practice, the physician can use the heart as a standard for the normal and reference. And mad, ^ evaluates the blood circulation function and the oxygen supply state in the blood, and further, the assessment of the energy, the lie, the blood, and the recent blood _ aging or elastic work and vascular reflex index (Re thin lonInd = =t tube hardening index, if the blood vessel pulse with ECG two parameters 'as a means of determining whether the blood vessel is aging

Vd〇^ ^ Bed use, because sheep = on ^ such as ^? As far as the electrocardiogram is concerned, the electrocardiograph above the polar level is based on the No. 1 material, so most of the three electrodes are used to obtain a single pass. However, from the principle of electrocardiogram measurement, in terms of blood vessels, the ECG signal of r ^ to 1. Index _RI system uses blood method to see ^, the current vascular sclerosis index _SI and vascular reflex with ECG ,, = ulse) scale, if the pulse wave _PWV, then k ° blood recorded society from the heart When the money is delivered to the blood vessel, a pressure wave is generated at the end of 1270364, called a pulse wave. Here is a diagram to illustrate the relationship between them. For example, the cephalometric shape of the finger can be divided into two parts. The path of the aorta directly reaches the finger, the second part is the transmission of the pulse wave to the lower body, the aorta and the subclavian artery are transmitted to the finger. The signal, the length of the delay between the first pulse peak and the rth far peak is mainly determined by the conduction time of the pulse wave from the path of the clavicular artery and then the j (four) pulse. The conduction time is in addition to the human body. Outside the height, the other blood is related to the body blood, and the body is better than the ridge. The conduction time is longer and the conduction speed is slower. Since the vascular pulse wave can reflect the spread of the bleeding g itself, the PWV can be obtained by calculating the w, & Electric Λ The technology of the existing vascular pulse waveform can be divided into the main force mode and the optical mode. The pressure mode is similar to the blood pressure measurement principle. The air bag/cuff bag (Cuff) is used to cover the part to be tested, and the filling gas is to be tested. After the site is pressed, the pressure is reduced to reduce the pulsation of the blood vessel, for example, (10) η = as claimed by Tech. Corp., No. 814, still in the form of a simple and π-view patent, and its published ColinVp_1〇〇〇 /2 〇〇〇, can measure the ratio of the foot and the upper arm blood pressure and the pulse PWV instrument 3 'is the application of pulse wave sensing in the full pressure mode. The optical method, the light, has the characteristics of reflection, absorption, and penetration, and takes the infrared light that is often used as an example. 'Because the oxygen-containing blood of the blood towel absorbs infrared light more than the oxygen-deficient blood, so the heart When contracting, for arteries, the oxygen-containing blood increases, that is, the light-absorbing substance increases', and the money travels faster, so the amount of light absorbed is more, and when the heart is diastolic, it will be beaten. Skin, the optical signal waveform obtained by Φ receiving vascular anger time and group female is called photoplethysmography technique, and the obtained waveform system is called photo plethysmography (PPG). In addition to the oxygen content in the blood, it can also reflect the vascular secret changes, and the calculation of SI, w, pwy and the source of the subtraction. For example, the US Patent Publication No. 2004/0015091 is applied to the ppG. At present, the pulsation waveform of blood vessels has been detected by photoplethysmography on the market, and is used by tf#red f, for example, Miw) (4).

TracePCA, model: PT2_ ' is an optical probe for detecting blood vessel waves, and further provides si instrument; and another PulseTrace pwv model: m〇〇〇, which simultaneously synchronizes with DoppleLHobe with three 1270364 electrodes. Taking the electrocardiogram and vascular pulse of the subject, using PWV〇 these parameters mentioned above, although it is quite helpful for assessing the heart and blood vessel status of the subject, and is currently used quite frequently in clinical practice, but in different Under the premise of the measurement principle, the existing instruments for the ECG signal, blood oxygen concentration and vascular pulse wave are extracted by different sensor components. Therefore, in order to obtain all the evaluation indexes of heart and blood vessels, it is necessary to use various Sense, the instrument II test, not only time-consuming and quite dependent. Therefore, listening to an effective and simple one-time acquisition of heart and blood official parameters, and a convenient and immediate understanding of their physical condition, the present invention combines the principles of optical measurement and the principle of electrical signal wide measurement, and designs an ECG signal and a management pulse. The integrated sensing device for wave and blood oxygen concentration, by combining the sensing interface of the sensing electrode and the optical probe, can not only extract the ECG signal, but also obtain a photo plethysmogram to further reflect the vascular pulse wave. With the oxygen content in the blood, through the calculation and analysis of the signal, the parameters can be obtained completely and simply as the basis for understanding the heart and blood vessels. SUMMARY OF THE INVENTION The main object of the present invention is to provide an integrated physiological signal measuring device, which utilizes a sensing interface combining optical sensing and electrical signal sensing, and can simultaneously extract the electrocardiogram signal and the optical volumetric map. For obtaining electrocardiogram, blood vessel waveform and blood oxygen concentration. Another object of the present invention is to provide a device for measuring cardiac and vascular function evaluation parameters, and obtaining an evaluation index of cardiac and vascular function by obtaining an electrocardiogram signal and a photoplemogram signal. A further object of the present invention is to provide a sensing interface capable of measuring a plurality of physiological signals, and integrating the electrocardiographic signal measuring technology and the optical sensing principle, so that the electrocardiogram signal and the blood vessel pulse waveform can be transmitted through a single interface. And the blood oxygen concentration is taken. Another object of the present invention is to provide a device capable of measuring and analyzing cardiac and vascular parameters. Through the design of a single sensing interface, in addition to extracting ECG signals, the blood vessel pulse and blood oxygen concentration can be simultaneously recorded, and the operation is performed. After analysis, heart and blood vessel related parameters such as heart rate, ST segment, QRS interval, blood oxygen concentration, vascular sclerosis index, vascular reflex index, pulse wave velocity, etc. can be obtained. In order to achieve the above object, the present invention is based on the two-electrode electrocardiographic signal measurement technology, and the new combination of optical physiological signal measurement of the 1270364 enables the electrocardiogram signal and the optical plethysmogram signal to be obtained through a single sensing interface. Further analysis of the basis of heart and blood vessel parameters not only simplifies the existing instruments and equipment, but also facilitates users to understand their heart and blood vessel conditions at any time. The purpose, technical contents, features and effects achieved by the present invention will become more apparent from the detailed description of the embodiments and the accompanying drawings. [Embodiment] The present invention provides an integrated physiological signal sensing device, which mainly utilizes the principle of electrical signal sensing and the principle of optical sensing, and obtains an electrocardiogram signal and a blood vessel by a single interface by combining the sensing elements. Physiological signals such as pulse wave and blood oxygen concentration. First of all, if the principle of vascular pulse wave is optically sensed, the first mention of Bill_Lambert law takes Shen_1^11^1^^), according to Bill_Lambert law (^咖丄啦13如,81 Grab) In the solution, if a certain wavelength of light is absorbed by the dissolved matter in the solution, the penetrating light 1 penetrating the solution will exponentially decay as the product of the dissolved matter (6) and the penetration distance of the light (6) , Gong: scd (1) 7> One of which S: the absorption coefficient of light by matter. In the same way, when light travels in biological tissues, although it is collected like skin color, muscle, bones, and blood, the light absorption of skin color, muscle, bone I. etc. is _, while blood job t3- is different. The amount of light absorbed. Due to the function of the circulatory system, the oxygen-deficient blood is in the lungs, and the rolling body is replaced by oxygenated blood, and then transmitted to the whole with the heart pulse; the technique can be used to check the heat of the blood, and more advanced (4) Blood = degree is a change with the pulse _, so from the oxygen volatility waveform can be converted to vascular pulsation wave 2 can be seen in the plethysmography of the non-vascular pulse shape, please be careful here, 啰 指Take the map waveform as an example. For example, the delay time from the first peak to the second peak depends mainly on the pulse wave locked to the lower limb and the _ clavicular artery _, assuming that the conduction distance is proportional to the human body ^ An official's 5 flatness is related, therefore, hardening of the arteries can be evaluated as follows: n-pass and blood (2) 1270364

SI

DVP

Subject^Jiei2h^ in ms 57 : vascular sclerosis index; : height of the subject; AT • delay between two peaks; the following shows the volume change waveform of the finger. ^DVP = X 100% (3) The height of the second peak: the height of the first peak. #The above formula (2) and formula (3) calculated, SI system can be estimated from the vascular pulse wave calculation, however, the right to estimate PWV, the need to cooperate with the ECG signal can be carried out, because PWV mainly lies in Evaluate the speed at which the heart sends blood waves from the blood vessels to the hands and feet. The larger the value, the harder the blood vessel wall, so the pulse wave velocity has a considerable relationship with the aforementioned SI. As shown in Fig. 3, when the degree of hardening of the blood vessel is like ceramic, the pulse wave is not easily absorbed by the blood vessel wall when it is transmitted, and the pulse wave velocity is increased. If the blood vessel is like a rubber tube, it is quite elastic, and the pulse wave is transmitted. It is absorbed by the tube wall, so the pulse wave speed is slowed down. According to the study, the pulse wave velocity is highly correlated with the incidence of cardiovascular disease. The higher the value of pulse wave velocity, the greater the probability of coronary artery disease. For the calculation of pulse wave velocity, refer to Figure 4, and the formula is as follows:

PTT

PWV D •• Pulse wave conduction distance; : Pulse wave transit time (4) 1270364 Order, need to combine "Telephone number, scale the heart to send the blood out time, as the reference point, due to _ number, carpel _ test Therefore, the R wave is required to change the vascular pulse wave. The PPG measured by a single light source can be expressed as the lack of progress. After the input of the light source of different wavelength bands, two PPGs are obtained, and the t system is obtained. The oxygen concentration in the blood, that is, the blood oxygen concentration can be estimated. Blood oxygen concentration is an important parameter for evaluating the human body. When the human body inhales, oxygen enters the human air tube from the outside, and is transmitted to the alveoli = body father, and the ship transfers the money to the whole body, and the supply group is divided into parts. The blood oxygen concentration is mainly 2 The concentration of oxygenated hemoglobin in the liquid, because the blood contains oxygenated blood and hypoxic blood, therefore, the oxygenated heme concentration (A) and the hypoxic heme concentration are measured by two light sources ( Booklet] 'Re-estimate the proportion of iso-oxygen hemoglobin, ie blood oxygen concentration (point A), the formula is as follows: [HbQ2] \Hb〇2b[Hb]

Sp〇2 (5) -ήΧίΟΟ% Book 2: Oxygenated hemoglobin concentration Hb: The concentration of hypoxic heme is here, and the calculation formula of the penetrating light intensity of formula (1) is required. However, for the convenience of calculation, it is defined here. A variable OD (solution light intensity), so that equation (1) can be written as:

=Ηγ)= scd (6) Red light and infrared light are the most commonly used light sources for detecting blood oxygen concentration. Especially for the 660nm and 940nm bands, bring them into equation (6): (7) OD( 660) = sHh〇i {66^)cHb〇2d + εΗΙ) (660)cHbd OD(940) = sHb〇i {9A^)cHb0d + sHb {9A^)cHbd Therefore,

Sp〇2 = _^g//h(94〇) - g(660)_ ReHb(9^) - %ό(660)+ 8mo1 (940) - sHb〇i (660) (8) where and αρ( 660) ', -0/)(940) 1270364 Measured = other arithmetic expressions of SI, M, PWV and SP 〇 2, due to the current feelings, too many parameters of the daily transmission must still be measured by different devices. Causes trouble in use. ^ Second, the oral two-electrode ECG sensing principle and optical sensing probe design, not only can t two electrical signals, blood vessel pulse and blood oxygen concentration of Na, is also very helpful for simplifying the medical U level, The specific device design description is as follows. ^ 5 ® is a device block diagram of the present invention. For example, the device of the present invention is configured as a sensing interface module 1G, and the sensing interface module 1G is composed of two sensing electrodes 12 and 12. The two optical probe sets 16 are composed of sensing electrodes 12 and 12, which are mainly responsible for the electrocardiogram reduction of the Na-subject, and the optical probe, the group 16 and the sensing electrodes 12 and 12 are combined with at least one of them. The light plethysmogram signal of the divergence, reflection and absorption characteristics of the light at the same time as the ECG signal is extracted. Here, the detailed design of the sensing interface module squeaking will be described later; The processing of the model money is electrically connected to the sensing interface module 1 , and the sensing interface module is mainly used: and the analogy format of the electric service and the optical image signal is processed. For example, the analogy/digital conversion unit% converts the heart and the light signal processed by the analog signal processing module 2G into a bit format of 'off. The post_digital signal processing module 4G performs digital signal processing and parameter calculation to the package §~law, ST segment The QRS segment and other electrocardiograms are sputum, si, Rj, pwv, SP02 and other vascular parameters; and when the parameters are processed, they are transmitted to the display unit 5G, such as LCD display no panel, LED display test H峨 complement calculation The selected d-record and the vascular parameters; in addition, the present invention further includes an electric-powered group 6G, which is electrically connected to the above-mentioned pools/units, to provide the overall I-mounted electrical energy> It is in the form of a battery or an external power supply such as a household outlet. In the present invention, the structure of the sensing interface module 10 is a unique design that enables the present invention to simultaneously capture a plurality of signals. Here, since the optical theory_signal can be distinguished into a reflective type and a transmissive type, the whole sense is The structure of the interface module 10 has different implementations. Moreover, since the electrocardiogram signal must be recorded by at least one electrode, and the blood vessel pulse wave or blood oxygen content is only required to be at least one set of optical detection, therefore, the optical leach 16 of the invention towel can be set in two senses. One of the electrodes 12, 12, or the two sensing electrodes 12, 12' may be provided. In the following embodiments, the implementation of the optical probe set 16 is combined with one of the sensing electrodes 12, 12'. The description is given. 11 1270364 a First, in terms of reflective optical theory, the iG structure of the sensing interface module of Qingcheng is as shown in Figure 6A. As shown in the figure, the sensing interface module 1 includes two sensing systems. The electrodes im, and - are disposed on the sensing electrode 12, at least one of the optical probe sets 16 . Since the sensing electrodes 12, 12' are mainly used for capturing the electrocardiographic signals, respectively, there is a contact surface 14 which is available. When the subject's body surface is recorded, the conduction to the surface of the limb changes to form an electrocardiogram; and in the portion of the optical probe set 16, at least one light source 鸠, and at least - light receiving The light source 160 emits light to the subject's body surface, and the light receiver 162 receives the light reflected from the subject tissue, that is, the light plethysmogram signal. Below the mouth, the signal measurement mechanism of the 6A diagram is illustrated by the brother 6B, and the sensing interface module 10 using the reflective optical principle has the greatest advantage that the entire sensing interface module can be rendered. Shape, ^ this, whether it is to make a non-polar, _, or the subject to touch, etc., can be easily measured, here, the figure is the finger of the subject The composition is measured, and the detecting electrode 12 is taken as an example (the other sensing electrode 12 is not advantageous. When the subject finger 18 is placed on the contact surface 14 of the sensing electrodes 12, 12, respectively, The measuring electrode, the π system 1 receiving = the electrocardiographic signal current transmitted to the finger 18 from the dirty rhythm, and the recording of the electrocardiogram signal is measured by the electrocardiogram measurement of the U-way, and the measurement by the left and right hands is the first a lead signal, and at the sensing electrodes 12, 12, measuring the ECG signal, because the sensing electrodes i2, 12, at least - are provided with a light source 160 and a light receiver 162, so if the blood vessel is desired The side of the wave, such as red light or infrared light, is transferred to the finger 18 due to changes in the heart's pulsation and absorption. By using the optical imr product plotting technique, the pulsating wave H of the subject finger 18 is obtained as an arithmetic expression of SI and w; and the PWV calculation is performed simultaneously with the sensing electrodes 12 and 12'. If you want to measure the oxygen content in the blood, you need to make the light of the common and long-term light--light and infrared* the most lack of negative blood, /' enable the light receiving 13 162 to receive the subject. The oxygen-containing blood of the blood towel is calculated according to the calculation of the SP02. The absorbed and reflected light 'provides the subsequent module using the above formula (5) to (8) into the second seventy-eighth diagram, which is the same concept of the invention but is applied. Schematic diagram of the transparent optical principle Wu Qian profile, as shown in the figure, the sensing interface module 1G system can further include 12 1270364 optical probes coated in the cool device 90 and the contact surface 14 upwards, which can make assumptions The light source 160 and the light receiver 162 are disposed at corresponding positions, and are here: again; again; the clamp 9 is a sensing electrode 12 (another sensing electrode 1;; L";: 22 r 12 160 , the corresponding upper side of 2; and when the light source 160 is disposed on the sensing electrode 12, the optical connection

The same sharpening fixture 90 is fixed above the corresponding light source 160, so that when the light source 160 is administrated to the subject, the light receiver 62 can receive light from the subject absorbed and worn by the tissue. In the design of FIG. 7A, when measuring, the subject only needs to place the two-finger-side on the sensing surface 12, the contact surface 14 (not shown), and the other side on the fixture 90. In the same way, the contact surface 14 of the sensing electrode 12 is also contacted with the sensing electrodes 12 and 12 to obtain the measured 'and the same, the single-light source, or the number of wires and the switching of the light source, ρ can be obtained. More than one optical plethysmogram signal is measured as a basis for calculation of seeing, illusion, and plaque. 〃

After explaining the design of the sensing interface module 10, in order to more clearly express the content of the present invention, please refer to Figure 8 and Figure 8 is a detailed block diagram of Figure 5, as shown in the figure, when tested When the device of the present invention is used, the sensing electrodes 12 and 12 of the sensing interface module 1G can pick up the electrocardiographic signals of the seven, and at the same time, the optical probe group 16 can be used to obtain the subject. The light volume is calculated by the nickname; after that, the analog signal processing module 2 〇 separately processes the extracted ECG signal and the optical plethysmogram signal, in the module 2〇, First, the ECG signal processing unit 22 is used to amplify and filter the ECG signal in the analog format. In addition, since the optical plethysmogram signal captured by the optical probe group 16 is in the optical signal format, Light

The electric volume conversion unit 24 converts the optical plethysmogram signal from the optical signal format to the electrical signal format, and uses a photoelectric signal processing unit 26 to perform signal amplification and filtering; and when the analog format processing is completed, the connection is continued. The signal processed by the analog signal processing module 20 can be converted into a digital format ECG signal and optical plethysmogram signal by the analog/digital conversion unit 30, and then transmitted to the digital signal processing module 40 for further processing. The signal processing and parameter calculation; the digital cryptographic processing module 40 mainly includes a central processing unit 42 for performing a series of calculation processing on the digital electrocardiogram and the digital photo plethysmogram signal to obtain It includes 4 parameters of heart rhythm, ST 13 1270364, QRS and vascular parameters including ridge hardening index, vascular reflex index, pulse wave velocity and blood saliency. The calculation process is described below. In the digital signal processing module 4〇, the parameter calculation processing flow is r = riding Chu said day \, please also refer to the fourth picture, such as _, when the digital ECG i digital light volume 彳 4 Cheng When the age is transmitted to the towel processing unit ,, for the digital signal, the processing procedure is as shown in step S1G, first of all, the digital heart and the electric wave are oscillated, and the normal ECG signal is composed of P wave and QRS wave. It is composed of the τ wave, and the current is caused by the current that the nano wave is rushing to the front. Therefore, the current wrinkles are larger, and the basis of the 1^-normal heart rate calculation is more important. In the continuation, step si2, ',, hunting is performed on the side of the QRS wave and the potential of the overall electrocardiogram, and the heart rate, st JQRS^I&quot; and other ECG parameters are obtained. In addition, for the processing of the digital photo plethysmogram signal, firstly, for the processing of the I-light plethysmogram signal, with the simple blood f pulse wave, if the processing is not performed in step S20, the pulse wave is detected first. At the arrival point, the determination of the arrival point of the pulse wave is not uniform at present, but the general-purpose upswing, the highest slope or the maximum age of the 4th figure #1 #2, #3 is used as the pulse wave. At the point of arrival, the present invention uses the maximum pulse rate f of the pulse as the identification of the arrival point of the pulse wave. After that, step S22 is performed to simultaneously compare the digits, the tiger and the digital light plethysmogram signal, and the singular wave of the s&amp; pulse arrival is estimated by the singular wave obtained by the digital electrocardiographic signal extraction. Close position, you can pass the pulse wave transmission (W). Next, the above formula (4) is introduced, wherein the read pulse wave conduction distance is estimated in accordance with the subject's body and the measured position, and pw can be obtained as in step S24. On the other hand, for the digital photoplethysmogram signal, step S3G is simultaneously performed, as shown in Fig. 2, the first peak and the second peak position, and the time difference between the two peaks and the lion amplitude is guided by the aforementioned Equation (2) and Equation (3), SI and RI can be obtained as in step S32. The above Pwv, SI and w can be calculated by the single-digit light f-figure signal. However, further, if two light plethysmograms U are obtained, for example, red light and infrared light are used as the light source, as shown in step S4 ,, the testee organization is separately estimated for the light _ , that is, the preparation of the signal of the peak of the signal, and then the introduction of the above equation (3) - equation (8), as shown in step S42, the blood oxygen concentration value is obtained. After the above description of the parameter calculation process of the present invention, please refer to the eighth figure again. After the calculation of the electrical parameter and the blood official parameter is completed, the obtained various parameters can be transmitted to the display unit 5〇, and the display 14 1270364 display unit 5G can be a liquid crystal display panel, an LED display panel, etc., so that the subject can obtain relevant parameter information. In addition, the digital signal processing module 4 of the present invention is connected to the center material unit 42 _, and the tree-turned plethysmogram signal and the calculated heart, electrical parameters, and blood f parameters. Step-by-step, digital signal processing mode (4) G can be ~ to - (four) transmission · 7G, material transmission can be used to pick up USB transmission interface, Bluetooth transmission interface, infrared transmission interface, data machine, etc., for storage The data in the storage unit 44, including parameters and signals, is output to an external digital information device 72, such as a personal computer, PDA, mobile phone, database, etc., to provide diagnostic analysis and data management. In addition, the integrated physiological signal position of the present invention may further comprise a _(four) unit (10), and the control unit 80 is connected to the central processing unit 42 so that the subject can set the control unit 8 In turn, the control unit 8〇 can control the operation of the entire digital signal processing module 4〇, and the control unit 8 can be in the form of a button, a knob, a touch panel, etc., for performing, for example, the selection of the measurement function and the increase of the private data of the storage unit. (I. Transmitting 'input of subject's personal data and date setting...etc. By providing power consumption of the whole device by the power module 60, each module/unit described above can operate smoothly, and the invention is achieved. To simulate and analyze the effects of various signals. The innovation of the invention combines the electro-mechanical technology and the optical-made technology, so that the ECG signal and the photoplethysmogram signal can be obtained by the same-sensing interface, which not only simplifies the existing instruments, but also Its integrated type can measure a variety of physiological signals, providing users with a convenient and quick understanding of their heart and blood vessel status, for cardiovascular prevention and health care, and the development of home medical care. The above-mentioned embodiments are merely for explaining the technical idea and characteristics of the present invention, and the purpose thereof is to enable the person skilled in the art to understand the contents of the present invention and implement it according to the application. </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; Schematic diagram of the path relationship. Fig. 2 is a schematic diagram of the waveform of the vascular pulse wave. Fig. 3 is a schematic diagram showing the relationship between the vascular pulse wave and the degree of atherosclerosis. Fig. 4 is a schematic diagram showing the relationship between the waveform of the vascular pulse wave and the waveform of the electrocardiogram signal. 15 1270364 Fig. 5 is Figure 6A is a schematic view showing the structure of the sensing electrode of the present invention. Fig. 6B is a schematic view showing the sensing electrode of the present invention. Fig. 7 is a schematic view showing another structure of the sensing electrode of the present invention. 8 is a detailed block diagram of the device of the present invention. Fig. 9 is a schematic diagram of the process of parameter calculation processing of the present invention. [Description of main component symbols] 10 sensing interface module 12, 12' sensing electrode 14 contact surface · 16 optical probe group 160 light source 162 optical receiver 18 subject's finger 20 analog signal processing module 22 ECG processing unit 24 photoelectric signal conversion unit 26 photoelectric signal processing unit 30 analog/digital conversion unit Xin 40 digital signal processing module 42 central processing arithmetic unit 44 storage unit 50 display unit 60 power supply module 70 data transmission module 72 external digital information device 80 control unit 90 fixture 16

Claims (1)

1270364 &gt; Patent Application Range: An integrated physiological signal measuring device, comprising: - a sensing interface module comprising two sensing electrodes and at least an optical probe set, and a sensing electrode is formed by a heart of the subject , electric eel, and the county department of the power test electric charm less than the combination of people, in the _ electricity _ take the _ person = electricity =, while taking the light plethysmogram signal of the subject; - analogy The signal is located in the 'contact' interface, which is used to connect the 4th signal of the test interface to the tester. - an analog/digital conversion unit that performs the electrocardiographic and optical plethysmograms processed by the voyage processing module into a digital signal and a digital plethysmogram signal; - a digital signal The reliance group has a towel processing unit, which is configured to process at least one ECG parameter and at least one blood vessel parameter; - display unit, The electrical system relies on the bribe to call the processing module, (4) displays the ECG parameter and the blood vessel parameter; and a power module is electrically connected to each of the above components to supply power. 2. The integrated physiological signal measuring device according to claim 1, wherein the sensing electrodes each have a contact surface for contacting the body surface of the subject, and the subject is operated. ECG signal. 3. The integrated physiological signal measuring device of claim 1, wherein the optical probe set comprises at least one light source for transmitting light to the subject and at least one light receiver for Receiving light from the subject. 4. The integrated physiological signal measuring device according to claim 3, wherein the light source and the optical receiver are disposed on the same sensing electrode. 5. The integrated physiological signal measuring device of claim 3, wherein when the light receiving state is disposed on the sensing electrode, the light source is disposed above the light receiving device; When the light source is disposed on the sensing electrode, the light receiver is disposed above the light source. 6. An integrated physiological signal measuring device according to claim 3, wherein the light source emitted by the light source comprises at least one of red light and infrared light. 7. The integrated physiological signal measuring device of claim 1, wherein the electrocardiographic parameter comprises at least one of a heart rhythm, a ST segment, and a QRS interval. 8. The integrated physiological signal measuring device according to claim 1, wherein the blood vessel parameter comprises at least one of a blood oxygen concentration, a hardening index, a blood vessel reflex index, and a pulse wave velocity. 9. The integrated physiological signal measuring device of claim 1, wherein the analog signal processing module comprises: an ECG processing unit that performs the ECG signal captured by the subject Signal amplification and signal filtering processing; an optoelectronic signal conversion unit converts the optical plethysmogram signal captured by the optical probe set to the subject into a telecommunication format; and an optoelectronic signal processing unit The photo-acoustic diagram signal of the telecommunication format is converted into signal amplification and signal filtering by the photoelectric signal conversion unit. The integrated physiological signal measuring device of claim 1, wherein the digital signal processing unit further comprises a storage unit electrically connected to the central processing unit, and (4) The telecommunication number and the Wei position light dragon signal, as well as the ECG parameters and the blood vessel parameters completed by the calculation process. 11 Green people. The integrated type of raw steel device, wherein the digital signal is connected to the data transmission module for transmitting the information and parameter data stored in the storage unit to the External digital information device. 12. The measuring device, wherein the data transmission, the infrared transmission interface, and the data machine are measured, wherein the external digit An integrated physiological signal quantity module according to claim 11 is one of a USB transmission interface and a Bluetooth transmission interface. For example, the amount of integrated physiological signal described in Item 11 is 13 13 , ^ 70 ^ 64 14 15 16 17 18 19 20 21 The resource is one of a computer, a personal digital assistant, and a mobile phone. , == an integrated physiological signal measurement, wherein the second connection is connected to the control unit to enable the subject to control the operation of the digital signal by setting the operation: . : 7L can be used, and the integrated physiological signal quantity described in Item 1 can be a battery.忒 Power Supply Module An integrated physiological signal measuring device according to the above item 1, wherein the external power supply device can be an external power supply device. The sensing interface module of the integrated physiological signal measuring device comprises: a sensing electrode respectively having a contact surface for taking the party tester ECG signal; and the power module can be used to contact a subject Body surface, 撷 She explores the secret, and combines with the sensory at least one of them. (4) The sensing is performed, and when the ECG signal is measured, the light plethysmogram signal of the subject is simultaneously taken. The invention relates to an integrated physiological signal measuring medium interface module, wherein the 'edge optical probe set comprises at least a light source for transmitting light to the subject, and at least one light a receiver for receiving light from the subject. The sensing interface module of the integrated physiological signal measuring device of claim 18, wherein the four light sources are disposed on the same sensing electrode as the optical receiver. The sensing interface module of an integrated physiological signal measuring device according to Item 18, wherein the light source is disposed on the sensing electrode, and the light source is disposed in the photoreceptor Above, when the light source is disposed on the sensing electrode, the light receiver is disposed above the corresponding light source. The sensing interface module of an integrated physiological signal measuring device according to claim 18, wherein the light system emitted by the light source includes at least one of infrared light and red light. 19