HK1209783A1 - 原肝幹細胞和近肝幹細胞 - Google Patents

原肝幹細胞和近肝幹細胞

Info

Publication number
HK1209783A1
HK1209783A1 HK15110414.0A HK15110414A HK1209783A1 HK 1209783 A1 HK1209783 A1 HK 1209783A1 HK 15110414 A HK15110414 A HK 15110414A HK 1209783 A1 HK1209783 A1 HK 1209783A1
Authority
HK
Hong Kong
Prior art keywords
primitive
stem cells
hepatic stem
proximal hepatic
proximal
Prior art date
Application number
HK15110414.0A
Other languages
English (en)
Inventor
洛拉‧里德
尼古拉斯‧
‧莫斯
馬克‧
‧福斯
約翰‧
‧拉德洛
安德魯‧
‧布魯斯
Original Assignee
Univ North Carolina
Vesta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Vesta Therapeutics Inc filed Critical Univ North Carolina
Publication of HK1209783A1 publication Critical patent/HK1209783A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
HK15110414.0A 2002-03-15 2015-10-22 原肝幹細胞和近肝幹細胞 HK1209783A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15

Publications (1)

Publication Number Publication Date
HK1209783A1 true HK1209783A1 (zh) 2016-04-08

Family

ID=28042021

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110414.0A HK1209783A1 (zh) 2002-03-15 2015-10-22 原肝幹細胞和近肝幹細胞

Country Status (18)

Country Link
US (4) US7413897B2 (zh)
EP (2) EP3023491A1 (zh)
JP (2) JP4723811B2 (zh)
KR (1) KR101119878B1 (zh)
CN (3) CN104630129A (zh)
AU (2) AU2003233399B2 (zh)
CA (1) CA2479510C (zh)
CY (1) CY1118167T1 (zh)
DK (1) DK1490480T3 (zh)
ES (1) ES2569951T3 (zh)
HK (1) HK1209783A1 (zh)
HU (1) HUE032238T2 (zh)
IL (1) IL164048A0 (zh)
MX (1) MXPA04009031A (zh)
PL (1) PL372619A1 (zh)
RU (1) RU2327479C2 (zh)
SI (1) SI1490480T1 (zh)
WO (1) WO2003078588A2 (zh)

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WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ－ｆｒｅｅ Ｓｅｌｆ－Ｏｒｇａｎｉｚｅｄ ３Ｄ ｓｙｎｔｈｅｔｉｃ ｔｉｓｓｕｅ）
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CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
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ES2664375T3 (es) * 2006-05-26 2018-04-19 The University Of North Carolina At Chapel Hill Precursores de células estrelladas hepáticas y métodos para aislarlos
JP2010529855A (ja) * 2007-06-15 2010-09-02 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 間葉系フィーダー細胞由来のパラ分泌シグナルならびにそれを用いる肝前駆体の増加および分化の調整
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞
WO2009134773A1 (en) * 2008-05-02 2009-11-05 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
EP2295537A4 (en) * 2008-05-14 2011-11-30 Public Univ Corp Yokohama City HUMAN HEPATIC STRAIN CELL, PREPARATION METHOD THEREFOR, METHOD OF INDUCING ITS DIFFERENTIATION AND METHOD OF USE
WO2009143241A2 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of multi-lineage progenitor cells to pancreatic cells
KR20110051166A (ko) 2008-05-22 2011-05-17 베스타 테라퓨틱스 인코포레이티드 포유동물의 전구 세포를 인슐린 생성 이자섬 세포로 분화시키는 방법
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
RU2580246C2 (ru) * 2009-10-30 2016-04-10 Дзе Юниверсити Оф Норт Каролина Эт Чапел Хилл Мультипотентные стволовые клетки внепеченочных желчных путей и способы их выделения
WO2012067259A1 (ja) 2010-11-19 2012-05-24 株式会社オンチップ・バイオテクノロジーズ 高濃度夾雑細胞群から低濃度の特定細胞を検出する方法と検出した細胞を回収し解析する方法
CN110511901A (zh) * 2011-05-27 2019-11-29 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
JP2015500279A (ja) 2011-12-08 2015-01-05 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 哺乳動物胎児肺細胞および該細胞の治療的使用
EP2864472A4 (en) * 2012-06-20 2015-12-30 Celula Inc MATERIALS AND METHODS FOR TREATING CELLULAR POPULATIONS
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG10201914005TA (en) * 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
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JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
EP4026563A1 (en) 2015-06-18 2022-07-13 Yeda Research and Development Co. Ltd Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
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CN104630129A (zh) * 2002-03-15 2015-05-20 北卡罗来纳大学查伯山分校 原肝干细胞和近肝干细胞

Also Published As

Publication number Publication date
CA2479510C (en) 2019-10-29
SI1490480T1 (sl) 2016-06-30
AU2008202656B8 (en) 2011-12-15
JP4723811B2 (ja) 2011-07-13
CN1742082B (zh) 2015-01-21
AU2003233399A1 (en) 2003-09-29
US20040018621A1 (en) 2004-01-29
JP2011087591A (ja) 2011-05-06
AU2008202656A1 (en) 2008-07-10
CN104630129A (zh) 2015-05-20
WO2003078588A9 (en) 2003-12-11
CN1742082A (zh) 2006-03-01
US8691523B2 (en) 2014-04-08
PL372619A1 (en) 2005-07-25
HUE032238T2 (en) 2017-09-28
AU2003233399B2 (en) 2008-03-20
EP1490480A2 (en) 2004-12-29
CY1118167T1 (el) 2017-06-28
EP3023491A1 (en) 2016-05-25
RU2327479C2 (ru) 2008-06-27
DK1490480T3 (en) 2016-04-11
KR20060010693A (ko) 2006-02-02
US20140302601A1 (en) 2014-10-09
WO2003078588A2 (en) 2003-09-25
JP2005520513A (ja) 2005-07-14
CA2479510A1 (en) 2003-09-25
EP1490480A4 (en) 2006-06-14
WO2003078588A3 (en) 2004-04-01
AU2008202656A8 (en) 2011-12-15
EP1490480B1 (en) 2016-02-03
KR101119878B1 (ko) 2012-03-09
AU2008202656B2 (en) 2011-03-17
RU2005125598A (ru) 2006-01-27
US20070099297A1 (en) 2007-05-03
JP5463271B2 (ja) 2014-04-09
US20170096641A1 (en) 2017-04-06
ES2569951T3 (es) 2016-05-13
MXPA04009031A (es) 2005-12-12
IL164048A0 (en) 2005-12-18
US7413897B2 (en) 2008-08-19

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